Zespół dresslera
Etiologia i przyczyny

Zespół Dresslera, będący późnym zespołem pozawałowym, to rzadkie, autoimmunologiczne zapalenie osierdzia rozwijające się zwykle od 2 do 10 tygodni po uszkodzeniu mięśnia sercowego, najczęściej po zawale mięśnia sercowego, operacjach kardiochirurgicznych lub urazach klatki piersiowej. Patogeneza opiera się na uwolnieniu antygenów sercowych, indukującym produkcję autoprzeciwciał i formowanie kompleksów immunologicznych, które wywołują stan zapalny w osierdziu, opłucnej i płucach. Czynniki ryzyka obejmują rozległość zawału, wcześniejsze zapalenie osierdzia, młodszy wiek, grupę krwi B ujemną oraz infekcje wirusowe (Coxsackie B, adenowirus, CMV). Obecnie częstość występowania zespołu wynosi poniżej 1%, co wiąże się z postępem w szybkiej rewaskularyzacji i nowoczesnych technikach leczenia zawału mięśnia sercowego.

Etiologia Zespołu Dresslera

Zespół Dresslera (ang. Dressler syndrome), znany również jako późny zespół pozawałowy, jest rzadkim, ale istotnym klinicznie schorzeniem charakteryzującym się zapaleniem osierdzia, które rozwija się kilka tygodni do kilku miesięcy po uszkodzeniu serca. Zespół ten należy do grupy schorzeń określanych jako zespoły pourazowe serca (post-cardiac injury syndromes, PCIS).123

Mechanizm immunologiczny

Dokładna przyczyna Zespołu Dresslera nie jest w pełni poznana, jednak powszechnie uważa się, że ma on podłoże autoimmunologiczne. Zgodnie z dominującą hipotezą, uszkodzenie mięśnia sercowego prowadzi do uwolnienia antygenów sercowych do krwiobiegu, co wywołuje reakcję immunologiczną.45 Organizm reaguje na uszkodzoną tkankę wysyłając komórki immunologiczne i przeciwciała w celu oczyszczenia i naprawy uszkodzonego obszaru. W niektórych przypadkach ta odpowiedź immunologiczna powoduje nadmierny stan zapalny w worku osierdziowym, co prowadzi do rozwoju Zespołu Dresslera.6

W patogenezie Zespołu Dresslera kluczową rolę odgrywają:78

  • Uwolnienie antygenów sercowych do krwiobiegu po uszkodzeniu mięśnia sercowego
  • Produkcja przeciwciał przeciwko tkankom serca (autoprzeciwciała przeciwmięśniowe)
  • Formowanie kompleksów immunologicznych i ich odkładanie w osierdziu, opłucnej i płucach
  • Wywołanie reakcji zapalnej w tych tkankach

78

Obserwacje kliniczne wspierające autoimmunologiczną etiologię Zespołu Dresslera obejmują:910

  • Okres utajenia między uszkodzeniem serca a pojawieniem się objawów
  • Korelację między mianem różnych przeciwciał (szczególnie przeciw aktynie i miozynie) a wystąpieniem klinicznym zespołu
  • Dobrą odpowiedź na leczenie przeciwzapalne

910

Przyczyny bezpośrednie

Zespół Dresslera może wystąpić po różnych uszkodzeniach serca. Najczęstsze przyczyny obejmują:1112

  • Zawał mięśnia sercowego (myocardial infarction) – historycznie najczęstsza przyczyna
  • Operacje kardiochirurgiczne, w tym:
    • Operacje na otwartym sercu
    • Pomostowanie aortalno-wieńcowe (CABG)
    • Wymiana zastawki aortalnej
  • Zabiegi inwazyjne, takie jak:
    • Przezskórna interwencja wieńcowa (angioplastyka i implantacja stentu)
    • Implantacja rozrusznika serca
    • Ablacja kardiologiczna
    • Izolacja żył płucnych
  • Uraz klatki piersiowej (tępy lub penetrujący)

13111

Zespół Dresslera jest jednym z kilku podobnych zespołów pourazowych serca, do których zaliczamy również:114

  • Zespół po perikardiotomii (postpericardiotomy syndrome)
  • Pozaurazowe zapalenie osierdzia
  • Zespoły jatrogennego uszkodzenia serca

114

Czynniki ryzyka Zespołu Dresslera

Identyfikacja czynników ryzyka ma kluczowe znaczenie dla wczesnego rozpoznania i profilaktyki Zespołu Dresslera. Do najważniejszych czynników ryzyka należą:115

Czynniki związane z uszkodzeniem serca

  • Rozległość zawału serca – ryzyko rozwoju Zespołu Dresslera jest większe u pacjentów, którzy przebyli rozległy zawał mięśnia sercowego1617
  • Operacje powodujące większe uszkodzenie miokardium – np. wymiana zastawki aortalnej18
  • Wcześniejszy epizod zapalenia osierdzia – zwiększa ryzyko nawrotu przy powtórnym uszkodzeniu serca19

1816

Czynniki indywidualne

  • Młodszy wiek pacjenta151
  • Grupa krwi B ujemna1518
  • Wcześniejsze leczenie prednizonem120

115

Czynniki infekcyjne

Infekcje wirusowe związane ze zwiększonym ryzykiem Zespołu Dresslera to:320

  • Wirus Coxsackie B
  • Adenowirus
  • Cytomegalowirus (CMV)

320

Badania epidemiologiczne wskazują, że częstość występowania Zespołu Dresslera jest wyższa w okresach zwiększonego występowania infekcji wirusowych w populacji ogólnej.17

Czynniki jatrogenne

  • Zastosowanie znieczulenia halotanowego podczas zabiegów chirurgicznych115

115

Epidemiologia Zespołu Dresslera

Zespół Dresslera był pierwotnie opisany przez Williama Dresslera w 1956 roku, który zaobserwował częstość występowania na poziomie 3-4% wszystkich przypadków ostrego zawału mięśnia sercowego.1516 Jednak w ciągu ostatnich dekad częstość występowania tego zespołu znacząco się zmniejszyła.

Aktualna częstotliwość występowania

Obecnie Zespół Dresslera uważany jest za rzadkie powikłanie, występujące u mniej niż 1% pacjentów po zawale mięśnia sercowego.1621 Niektóre badania sugerują nawet, że zespół praktycznie zanikł.915 Według niektórych źródeł, jedynie około 0,1% osób, które przeszły zawał serca, rozwija Zespół Dresslera.22

W przypadku innych zabiegów kardiologicznych, takich jak zamknięcie uszka lewego przedsionka (LAAO), częstość występowania Zespołu Dresslera szacuje się na około 1%.23

Przyczyny spadku częstotliwości występowania

Znaczący spadek częstości występowania Zespołu Dresslera przypisuje się przede wszystkim postępowi w leczeniu ostrego zawału mięśnia sercowego, w szczególności:1521

  • Szybkiej rewaskularyzacji jako podstawy leczenia ostrego zawału mięśnia sercowego
  • Metodom reperfuzji, które zmniejszają wielkość obszaru zawałowego, a tym samym obszar uszkodzonego miokardium
  • Poprawie technik interwencyjnych w kardiologii

1521

Zrozumienie, że zmniejszenie obszaru uszkodzenia mięśnia sercowego koreluje z niższym ryzykiem rozwoju Zespołu Dresslera, podkreśla znaczenie szybkiej interwencji i nowoczesnych technik leczenia zawału serca.15

Przebieg i powikłania Zespołu Dresslera

Okres utajenia

Charakterystyczną cechą Zespołu Dresslera jest okres utajenia między uszkodzeniem serca a pojawieniem się objawów. Typowo objawy występują:241625

  • Od 2 do 10 tygodni po zawale mięśnia sercowego
  • Od kilku tygodni do kilku miesięcy po operacji serca lub urazie

2425

Ten odległy w czasie rozwój objawów, w przeciwieństwie do wczesnego zapalenia osierdzia związanego z zawałem (które występuje w ciągu pierwszych dni po zawale), stanowi podstawę do rozpoznania Zespołu Dresslera jako oddzielnej jednostki chorobowej.2627

Powikłania

Choć Zespół Dresslera zwykle nie zagraża życiu, mogą wystąpić istotne powikłania:2128

  • Wysięk osierdziowy – gromadzenie się płynu w worku osierdziowym, występuje często u pacjentów z Zespołem Dresslera2627
  • Tamponada serca – w rzadkich przypadkach nadmierne gromadzenie się płynu w worku osierdziowym może prowadzić do zagrażającej życiu tamponady2128
  • Wysięk opłucnowy – odpowiedź immunologiczna może również powodować gromadzenie się płynu w opłucnej, najczęściej jednostronnie po stronie lewej (83% przypadków)2930
  • Zaciskające zapalenie osierdzia – przewlekły stan zapalny może prowadzić do pogrubienia lub bliznowacenia osierdzia28

2128

Nawroty

Nawroty Zespołu Dresslera są częste, a pacjenci mogą doświadczać objawów nawet do roku po początkowym incydencie.3132 Wcześniejszy epizod Zespołu Dresslera zwiększa ryzyko nawrotu przy powtórnym zawale mięśnia sercowego, co stanowi najważniejszy czynnik ryzyka nawrotu.19

Ze względu na potencjalne powikłania i możliwość nawrotów, ważne jest, aby klinicyści zachowali czujność wobec pacjentów zgłaszających się z nowymi dolegliwościami bólowymi w klatce piersiowej, zmęczeniem lub objawami aktywnego stanu zapalnego po przebytym zawale mięśnia sercowego.21

Znaczenie kliniczne

Pomimo spadku częstości występowania, Zespół Dresslera pozostaje istotną jednostką chorobową, którą klinicyści powinni uwzględniać w diagnostyce różnicowej u pacjentów po uszkodzeniu serca.33 Szybkie rozpoznanie i właściwe leczenie mogą zapobiec poważnym powikłaniom i poprawić rokowanie pacjenta.

Leczenie Zespołu Dresslera opiera się głównie na stosowaniu niesteroidowych leków przeciwzapalnych (NLPZ) takich jak aspiryna, ibuprofen lub naproksen, które są stopniowo redukowane w ciągu 4-6 tygodni w miarę zmniejszania się wysięku wokół serca.3132 W przypadku opornych objawów zaleca się rozważenie kolchicyny i wysokich dawek NLPZ.21

W świetle nowoczesnych metod leczenia zawału mięśnia sercowego, skupionych na szybkiej rewaskularyzacji, zapobieganie Zespołowi Dresslera nie jest już tak istotne jak dawniej.15 Jednak zrozumienie jego patogenezy i czynników ryzyka pozostaje ważne dla kompleksowej opieki nad pacjentami kardiologicznymi.

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  1. 11.04.2026
  2. www.leksykon.com.pl

Materiały źródłowe

  • #1 Dressler Syndrome – StatPearls – NCBI Bookshelf
    https://www.ncbi.nlm.nih.gov/books/NBK441988/
    Dressler syndrome is part of a group of post-cardiac injury syndromes, which include: postpericardiotomy syndrome, post-traumatic pericarditis from blunt or penetrating trauma, and iatrogenic causes including percutaneous coronary or intracardiac interventions, pacemaker lead insertion, and radiofrequency ablation. […] The exact cause of Dressler syndrome is unknown, though it is presumed that an initial injury to mesothelial pericardial cells combined with blood in the pericardial space triggers an immune response and results in an immune complex deposition in the pericardium, pleura, and lungs which causes an inflammatory response. […] The risk of developing Dressler syndrome tends to be greater in post-MI patients who have suffered a more extensive infarction. […] Additional predisposing factors for Dressler syndrome include: viral infections, surgeries involving more significant myocardial damage, younger age, prior history of pericarditis, prior treatment with prednisone, B negative blood type, and use of halothane anesthesia. […] The exact cause of Dressler syndrome is unknown, though it is thought to be immune-mediated.
  • #2 Post-cardiac injury syndromes – UpToDate
    https://www.uptodate.com/contents/post-cardiac-injury-syndromes
    Pericarditis with or without a pericardial effusion resulting from injury of the pericardium constitutes the post-cardiac injury syndrome. The principal conditions considered under this rubric are: […] Post-myocardial infarction (MI) (Dressler syndrome) […] Posttraumatic pericarditis (caused by traumatic or iatrogenic injury)
  • #3 Dressler Syndrome | Treatment & Management | Point of Care
    https://www.statpearls.com/point-of-care/20700
    Dressler syndrome is part of a group of post-cardiac injury syndromes, which include: postpericardiotomy syndrome, post-traumatic pericarditis from blunt or penetrating trauma, iatrogenic causes including percutaneous coronary or intracardiac interventions, pacemaker lead insertion, radiofrequency ablation. […] The exact cause of Dressler syndrome is unknown, though it is presumed that an initial injury to mesothelial pericardial cells combined with blood in the pericardial space triggers an immune response and results in an immune complex deposition in the pericardium, pleura, and lungs which causes an inflammatory response. […] Viruses that have been associated with Dressler syndrome include: Coxsackie B, Adenovirus, Cytomegalovirus.
  • #4 Health Information Library | Rumah Sakit Pusat Pertamina
    https://rspp.co.id/dcontent.html?id=CON-20371798&n=Dressler%20syndrome
    Dressler syndrome is swelling and irritation of the sac around the heart that happens after damage to the heart muscle. The damage may trigger an immune system response that causes the condition. The damage can result from a heart attack, heart surgery or a serious injury. […] Experts think Dressler syndrome is caused by the immune system’s response to heart damage. The body reacts to the injured tissue by sending immune cells and proteins called antibodies to clean up and repair the affected area. Sometimes this response causes swelling due to the inflammation in the sac around the heart that’s known as the pericardium. […] Dressler syndrome can happen after a heart attack or some heart surgeries or procedures. It also can happen after a serious injury to the chest, such as trauma from a car accident.
  • #5 Dressler syndrome // Middlesex Health
    https://middlesexhealth.org/learning-center/diseases-and-conditions/dressler-syndrome
    Dressler syndrome is inflammation of the sac surrounding the heart (pericarditis). It’s believed to occur as the result of the immune system responding to damage to heart tissue or damage to the sac around the heart (pericardium). The damage can result from a heart attack, surgery or traumatic injury. […] Experts think Dressler syndrome is caused by the immune system’s response to heart damage. The body reacts to the injured tissue by sending immune cells and proteins (antibodies) to clean up and repair the affected area. Sometimes this response causes inflammation in the pericardium. […] Dressler syndrome may occur after certain heart surgeries or procedures.
  • #6 Dressler syndrome – Augusta HealthSearchClose SearchSearch IconSearch IconClose Search IconMobile Menu IconMobile Menu Close IconInstagramFacebookTwitterYoutube
    https://www.augustahealth.com/disease/dressler-syndrome/
    Dressler syndrome is believed to be an immune system response after damage to heart tissue or to the sac surrounding the heart (pericardium). Such damage may occur from events such as a heart attack, surgery or traumatic injury. […] Experts think Dressler syndrome is caused by the immune system’s response to heart damage. Your body reacts to the injured tissue by sending immune cells and proteins (antibodies) to clean up and repair the affected area. Sometimes this response causes excessive inflammation in the pericardium. […] Dressler syndrome may occur after certain heart surgeries or procedures.
  • #7 Post-cardiac injury syndrome in the Emergency Department: mini-review
    https://www.immunologyresearchjournal.com/articles/postcardiac-injury-syndrome-in-the-emergency-department-minireview.html
    The PCIS appears to be produced by an initial injury to the myocardium, leading to the release of cardiac antigens that stimulate the immune response. Immune complexes are then generated and deposit in the pericardium, pleura, and lungs, eliciting an inflammatory response. […] The exact pathogenesis of PCIS remains uncertain. PCIS seems to be an autoimmune phenomenon mediated by a combined activation of both cell-mediated and humoral mechanisms. Some observations supporting this association are the latent period between cardiac injury and the onset of PCIS, the correlation between titers of different antibodies (particularly the elevated levels of anti-actin and anti-myosin antibodies) and the clinical occurrence of PCIS and the excellent response to anti-inflammatory therapy. However, the significance of these antibodies and their relation to the severity of myocardial injury is still unclear.
  • #8 Post-cardiac injury syndrome: aetiology, diagnosis, and treatment
    https://www.escardio.org/Journals/E-Journal-of-Cardiology-Practice/Volume-15/Post-cardiac-injury-syndrome-aetiology-diagnosis-and-treatment
    Post-myocardial infarction pericarditis can be differentiated into early infarct-associated pericarditis and late post-myocardial infarction pericarditis, also known as Dresslers syndrome. […] Dresslers syndrome, on the other hand, occurs two to eight weeks after infarction and is also very rare nowadays in clinical settings. […] Newer studies have reported the de facto disappearance of Dresslers syndrome, a fact that is not yet fully understood. […] Based on these observations and insights from animal models, we therefore hypothesise that systemic release of cardiac antigens, together with non-specific, injury-mediated activation of the innate immune system initiate adaptive self-antigen specific responses, as evidenced by an increase of antimyocardial antibody titers and expansion of heart-specific CD4 T cells, which in turn promote recruitment of myelo-derived inflammatory cells to the heart. […] Taken together, the latency period between cardiac injury and PCIS, as well as the generally favourable response to anti-inflammatory drugs, both strongly support the hypothesis of an autoimmune-mediated pathogenesis.
  • #8 Dressler’s syndrome – Knowledge and References – Taylor & Francis
    https://taylorandfrancis.com/knowledge/Medicine_and_healthcare/Cardiology/Dressler%27s_syndrome/
    Dressler’s syndrome, also known as late post-myocardial infarction syndrome or post-infarction syndrome, is an autoimmune condition that typically occurs 1-6 weeks after a heart attack. It is characterized by pericarditis, pleurisy, and malaise, and is caused by a delayed inflammatory response following acute coronary syndrome. […] Dressler syndrome, also called late post-myocardial infarction syndrome, is a well-recognized post-cardiac injury syndrome where pericarditis is preceded by acute coronary syndrome, with a delayed inflammatory response usually several weeks after the initial event. It is believed to occur secondary to formed antimyocardial antibodies as a delayed autoimmune process causing symptoms of pericarditis in the late post-myocardial infarction stage. […] Dressler syndrome is due to autoantibodies against sarcolemma + subsarcolemma of myocytes.
  • #9 Post-cardiac injury syndrome: aetiology, diagnosis, and treatment
    https://www.escardio.org/Journals/E-Journal-of-Cardiology-Practice/Volume-15/Post-cardiac-injury-syndrome-aetiology-diagnosis-and-treatment
    Post-myocardial infarction pericarditis can be differentiated into early infarct-associated pericarditis and late post-myocardial infarction pericarditis, also known as Dresslers syndrome. […] Dresslers syndrome, on the other hand, occurs two to eight weeks after infarction and is also very rare nowadays in clinical settings. […] Newer studies have reported the de facto disappearance of Dresslers syndrome, a fact that is not yet fully understood. […] Based on these observations and insights from animal models, we therefore hypothesise that systemic release of cardiac antigens, together with non-specific, injury-mediated activation of the innate immune system initiate adaptive self-antigen specific responses, as evidenced by an increase of antimyocardial antibody titers and expansion of heart-specific CD4 T cells, which in turn promote recruitment of myelo-derived inflammatory cells to the heart. […] Taken together, the latency period between cardiac injury and PCIS, as well as the generally favourable response to anti-inflammatory drugs, both strongly support the hypothesis of an autoimmune-mediated pathogenesis.
  • #10 Post-cardiac injury syndrome in the Emergency Department: mini-review
    https://www.immunologyresearchjournal.com/articles/postcardiac-injury-syndrome-in-the-emergency-department-minireview.html
    The PCIS appears to be produced by an initial injury to the myocardium, leading to the release of cardiac antigens that stimulate the immune response. Immune complexes are then generated and deposit in the pericardium, pleura, and lungs, eliciting an inflammatory response. […] The exact pathogenesis of PCIS remains uncertain. PCIS seems to be an autoimmune phenomenon mediated by a combined activation of both cell-mediated and humoral mechanisms. Some observations supporting this association are the latent period between cardiac injury and the onset of PCIS, the correlation between titers of different antibodies (particularly the elevated levels of anti-actin and anti-myosin antibodies) and the clinical occurrence of PCIS and the excellent response to anti-inflammatory therapy. However, the significance of these antibodies and their relation to the severity of myocardial injury is still unclear.
  • #11 Dressler Syndrome: Causes, Diagnosis, and Treatment
    https://www.healthline.com/health/dressler-syndrome
    Dressler syndrome is thought to occur when the immune system responds excessively following one of these events. […] The exact cause of Dressler syndrome isn’t clear. It’s believed to occur when a heart surgery or heart attack triggers an immune response in the pericardium. […] Some of the events that have been known to trigger Dressler syndrome include: heart surgery, like open-heart surgery or coronary artery bypass surgery, percutaneous coronary intervention, also known as coronary angioplasty and stent placement, implantation of a pacemaker, cardiac ablation, pulmonary vein isolation, penetrating trauma to the chest.
  • #12 Dressler’s Syndrome: Causes, Symptoms and Treatment
    https://my.clevelandclinic.org/health/diseases/17947-dresslers-syndrome
    Dresslers syndrome is a kind of pericarditis, or inflammation of the sac around the outside of your heart. A heart attack or other type of heart damage may set off an immune system reaction that leads to Dresslers syndrome. […] Dresslers syndrome is a form of pericarditis, or inflammation of the pericardium, a tough elastic sac that surrounds your heart. This may happen when your immune system reacts after some type of damage to your heart. […] Healthcare experts dont know the exact cause of Dresslers syndrome. They believe its the result of an immune system response following injury or damage to the cells of your heart or pericardium. […] Possible Dresslers syndrome causes include: Heart attack (myocardial infarction). Heart surgery. Invasive procedures, such as cardiac ablation or implantation of a pacemaker. Chest injury or trauma.
  • #13 Dressler’s Syndrome Causes, Symptoms and Treatment
    https://www.netmeds.com/health-library/post/dresslers-syndrome-causes-symptoms-and-treatment?srsltid=AfmBOooh_ZOdLPAS-FPA9SfHmFktj4R1zNE9w7jdrzesWb9ulhYRUZPD
    Dresslers syndrome is a type of pericarditis, wherein the sac surrounding the heart, i.e. the pericardium gets inflamed. […] Also referred to as post-myocardial infarction syndrome, post-pericardiotomy syndrome, or post-cardiac injury syndrome since it happens as a sort of excessive immune response by the body after damage to the heart tissue or to the pericardium, from events such as a heart attack (myocardial infarction), heart surgery, heart procedure, or chest trauma due to an accident or injury. […] Although the exact cause of Dressler syndrome isn’t clear, this painful inflamed condition of the heart chiefly occurs as a major immune response to heal the wound and help repair the affected area. But sometimes this response can lead to excessive inflammation in the pericardium. […] Some events that can trigger an immune response and cause Dresslers syndrome includes: Heart surgery, including both open-heart surgery and coronary artery bypass surgery, Implantation of a pacemaker, Percutaneous coronary intervention, i.e. coronary angioplasty or stent placement, Pulmonary vein isolation, Cardiac ablation, A trauma in the chest.
  • #14 Dressler syndrome – Knowledge and References – Taylor & Francis
    https://taylorandfrancis.com/knowledge/Medicine_and_healthcare/Cardiology/Dressler_syndrome/
    Post-cardiac injury syndrome (PCIS) is a complex, heterogenous group of immune-mediated disorders related to pericardial, epicardial and myocardial inflammation following an inciting event, most often following surgical or procedural trauma, iatrogenic or accidental injury and finally, post-myocardial infarction. The reason for this heterogeneity relates to the variable chronology of presentation, differing etiology and severity of disease.
  • #15 Dressler’s Syndrome | Doctor
    https://patient.info/doctor/dresslers-syndrome
    Dressler’s syndrome was first described in 1956. It is thought to be immune-mediated (anti-myocardial antibodies may be present, although it is not known whether these are the cause of the syndrome or occur as a result of it.1 ). […] It is one of a heterogeneous group of conditions collectively known as post-cardiac injury syndrome (PCIS), which together represent a leading cause of pericarditis.2 PCIS includes Dressler’s syndrome (late-onset pericarditis following myocardial infarction (MI)), early-onset pericarditis following MI, post-cardiotomy syndrome and post-traumatic pericarditis. […] The original paper by Dressler in 1956 suggested an incidence of 3-4% of all cases of acute MI.5 It is now much rarer, probably due to reperfusion methods of management of an acute MI, occurring in fewer than 1% of cases, with some studies suggesting it has disappeared altogether.2 6 7 The reduction may be due to the fact that active intervention reduces the size of the infarct and therefore the area of damaged myocardium.
  • #15 Dressler’s Syndrome | Doctor
    https://patient.info/doctor/dresslers-syndrome
    Other risk factors which have been suggested include viral infections, younger age, prior treatment with prednisone, B negative blood type, and use of halothane anaesthesia.1 […] Prevention is no longer needed now that modern management of myocardial infarction has resulted in a reduction in the incidence of this syndrome.
  • #16 Dressler Syndrome: Not Just a Relic of the Past
    https://pmc.ncbi.nlm.nih.gov/articles/PMC9681686/
    Dressler syndrome, also known as post-myocardial infarction syndrome, is a condition in which sterile pericarditis develops shortly after myocardial injury. […] Dressler syndrome is commonly associated with acute myocardial infarction (MI) but can present after cardiac surgeries, trauma to the thorax, electrophysiology (EP) procedures, and other insults to the myocardium or surrounding tissues. […] It is felt that tissue infarction causes release of intracellular components leading to auto-antibody production against myocardial and pericardial tissue. […] While historically more common, the improvement in coronary revascularization technologies has made Dressler syndrome a relatively rare occurrence with an estimated incidence of less than 1% of post-MI patients. […] Estimates vary but even prior to the advent of coronary revascularization, its incidence was estimated to be in the range of 3-5% by some studies.
  • #17 Dressler Syndrome (Postmyocardial Infarction Syndrome) – MD Searchlight
    https://mdsearchlight.com/heart-health/dressler-syndrome-postmyocardial-infarction-syndrome/
    Dressler syndrome, or post-heart attack syndrome, is a type of inflammation of the tissue around the heart, possibly with fluid buildup, caused by damage to the heart or surrounding tissues. […] The precise cause of Dressler syndrome is not clear, but it seems to involve some kind of initial damage to the cells lining the pericardium (the sac around the heart). […] Dressler syndrome is one of several conditions known as post-cardiac injury syndromes. […] Each of these conditions represents a different case where the heart or its surrounding areas have been harmed and responded with inflammation. […] The risk of Dressler syndrome is higher in heart attack patients who’ve had extensive heart tissue damage. […] The incidence of Dressler syndrome seems to be higher during periods when viral infections are more common in the general population.
  • #18 Dressler’s syndrome – wikidoc
    https://wikidoc.org/index.php/Dressler%27s_syndrome
    Dressler’s syndrome or post-myocardial infarction syndrome is a form of pericarditis that occurs in the setting of myocardial infarction. […] Dressler’s syndrome results from an autoimmune inflammatory reaction to myocardial neo-antigens. […] Although the exact cause remains unknown, Dressler’s syndrome is believed to result from an autoimmune inflammatory reaction to myocardial neo-antigens, as well as injury to the mesothelial pericardial cells. […] The common causes of Dressler’s syndrome include: Surgeries associated with myocardial damage, myocardial infarction, and pulmonary embolism. […] The risk of Dressler’s syndrome increases with the size of the infarction. […] Epidemiological studies showed a higher risk ratio of Dressler’s syndrome with cardiac surgeries associated with greater myocardial damage as aortic valve replacement, younger age, prior treatment with prednisone, B-negative blood type, halothane anesthesia, and viral infections that have been associated with Dressler’s syndrome.
  • #19 *Dressler Syndrome* What is… – BB Medical EducationFacebookShared with Public
    https://www.facebook.com/bendreajay/posts/dressler-syndromewhat-is-dressler-syndromedressler-syndrome-is-a-type-of-pericar/346051010496067/
    The exact cause of Dressler syndrome isn’t clear. It’s believed to occur when a heart surgery or heart attack triggers an immune response in the pericardium. In response to an injury, the body typically sends immune cells and antibodies to help repair the area. However, an immune response can sometimes cause an excessive amount of inflammation. […] Some of the events that have been known to trigger Dressler syndrome include: Heart surgery, such as open-heart surgery or coronary artery bypass surgery, Percutaneous coronary intervention, also known as coronary angioplasty and stent placement, Implantation of a pacemaker, Cardiac ablation, Pulmonary vein isolation, Penetrating trauma to the chest. […] The risk of Dressler’s syndrome increases with the size of the infarction. Further, a former episode of Dressler’s syndrome increases the risk of relapse upon recurrent myocardial infarction (the most important risk factor).
  • #20 Dressler’s syndrome: Causes, symptoms, and treatments
    https://www.medicalnewstoday.com/articles/dresslers-syndrome
    Dresslers syndrome is a rare but treatable type of inflammation in the sac surrounding the heart. It develops shortly after a heart injury, such as a heart attack, and may return after treatment. […] However, Dresslers syndrome is an extremely rare type of pericarditis that usually develops after a heart injury. It might occur due to immune activity that causes inflammation after a heart injury by responding excessively. […] The direct cause of Dresslers syndrome is unclear. According to the Autoimmune Association, damaged heart tissue releases proteins that may signal to the immune system that repair is necessary in the area. This immune response might lead to inflammation in the pericardium. […] Underlying risk factors for developing Dresslers syndrome after heart surgery or injury include: viral infections, especially by Coxsackie B, adenovirus, and cytomegalovirus; a history of heart surgery that causes damage to tissue, such as aortic valve replacement; having heart problems at a younger age; a history of pericarditis; having taken prednisone, a steroid medication, to treat pericarditis; having B negative blood type; using halothane anesthesia during a surgical procedure.
  • #21 Dressler Syndrome: Not Just a Relic of the Past
    https://pmc.ncbi.nlm.nih.gov/articles/PMC9681686/
    With the emphasis on rapid revascularization as the cornerstone of treatment in acute MI, the incidence of post-MI syndrome has dropped even further and is now estimated to develop in as few as 1% of patients after MI. […] Importantly for clinicians, this triad has very poor sensitivity and is present in only a minority of patients. […] While typically not life-threatening, serious complications such as cardiac tamponade have been described. […] To increase prompt diagnoses of post-MI syndrome, clinicians should maintain a degree of suspicion for any patient presenting with new chest pain, fatigue, or signs/symptoms of active inflammation after sustaining MI. […] Once post-MI syndrome is confirmed or strongly suspected, treatment with colchicine and high-dose non-steroidal anti-inflammatory agents such as aspirin or indomethacin should be considered to prevent refractory symptoms.
  • #22 Dressler Syndrome | Symptoms & Causes | Freedmans Health
    https://freedmanshealth.org/disease-conditions/symptoms-causes/dressler-syndrome/
    Dresslers syndrome is a form of pericarditis, or inflammation of the pericardium, a tough elastic sac that surrounds your heart. This may happen when your immune system reacts after some type of damage to your heart. […] Dresslers syndrome can happen after: A heart attack (myocardial infarction). Heart surgery. A heart procedure. Chest trauma from an accident or injury. […] Risk factors that make you more likely to get Dresslers syndrome include: Heart attack (myocardial infarction). Heart surgery. Heart procedure. Chest trauma as the result of an accident or injury. Previous use of prednisone (Rayos or Sterapred). Viral infection. Previous case of pericarditis. […] Dresslers syndrome is rare, possibly because of medical advances in treating heart attacks. Only 0.1% of people who have a heart attack get Dresslers syndrome.
  • #23 43 Dressler’s syndrome post left atrial appendage occlusion: a rare diagnoses resurfaces | Heart
    https://heart.bmj.com/content/108/Suppl_3/A36
    Dresslers Syndrome also known as post myocardial infarction syndrome is a secondary pericarditis that can occur after cardiac myocyte damage. […] Such damage can occur after a myocardial infarction or routine endovascular surgery. […] DS is a rare complication of the LAAO procedure with one study documenting a 1% incidence. […] The association of DS as a complication post LAAO is exceptionally rare. Its uniqueness may be attributable to several causal factors including its ability to mimic more common conditions, along with its declining incidence via improved revascularisation techniques.
  • #24 Dressler’s syndrome – Autoimmune Association
    https://autoimmune.org/disease-information/dresslers-syndrome/
    Dressler’s syndrome is believed to be an immune system response following damage to heart tissue or the pericardium, such as a heart attack, surgery or traumatic injury. […] Symptoms are likely to appear weeks to months after a heart attack, surgery or other heart injury.
  • #25 Dressler’s Syndrome: Understanding the Causes, Symptoms and Treatment
    https://www.clinicianrevision.com/courses/cardiology/lessons/pericardial-disease/topic/dresslers-syndrome/
    Dresslers syndrome is a rare complication that can develop 2-10 weeks post-myocardial infarction or heart surgery. […] The exact cause of Dresslers Syndrome is not known, but it is thought to be an immune response to myocardial injury. Myocardial antigens or neo-antigens from the damaged heart tissue may stimulate the immune system to produce inflammation in the pericardium.
  • #26 Pericarditis – after heart attack – UF Health
    https://ufhealth.org/conditions-and-treatments/pericarditis-after-heart-attack
    Dressler syndrome is thought to occur when the immune system attacks healthy heart tissue by mistake. […] Late pericarditis: This is also called Dressler syndrome. It is also called post-cardiac injury syndrome or postcardiotomy pericarditis). It most often develops several weeks or months after a heart attack, heart surgery, or other trauma to the heart. […] A buildup of fluid in the covering of the heart or space around the lungs (pericardial effusion) is not common after a heart attack. But, it often does occur in some people with Dressler syndrome.
  • #27 Pericarditis – after heart attack Information | Mount Sinai – New York
    https://www.mountsinai.org/health-library/diseases-conditions/pericarditis-after-heart-attack
    Dressler syndrome is thought to occur when the immune system attacks healthy heart tissue by mistake. […] Late pericarditis: This is also called Dressler syndrome. It is also called post-cardiac injury syndrome or postcardiotomy pericarditis. It most often develops several weeks or months after a heart attack, heart surgery, or other trauma to the heart. […] A buildup of fluid in the covering of the heart or space around the lungs (pericardial effusion) is not common after a heart attack. But, it often does occur in some people with Dressler syndrome.
  • #28 Dressler’s Syndrome Treatment | Mya Care
    https://myacare.com/procedure/dressler-s-syndrome-treatment
    Dressler’s syndrome can occur due to a heart attack (myocardial infarction), a heart treatment (percutaneous coronary or intracardiac interventions, pacemaker lead insertion, radiofrequency ablation), cardiac surgery, or chest trauma caused by an injury or an accident. […] The immunological response that causes Dresslers syndrome may also result in pleural effusion. This happens when fluid builds up in the membranes around your lungs. […] In rare situations, chronic inflammation in the heart can lead to life-threatening consequences such as Cardiac Tamponade. This occurs when fluids accumulate in the sac around the heart. […] Chronic cardiac inflammation can also result in constrictive pericarditis. This occurs when the pericardium thickens or scars due to chronic inflammation.
  • #29 DRESSLER’S SYNDROME WITHOUT A MYOCARDIAL INFARCTION: A RARE COMPLICATION OF PACEMAKER IMPLANTATION – SHM Abstracts | Society of Hospital Medicine
    https://shmabstracts.org/abstract/dresslers-syndrome-without-a-myocardial-infarction-a-rare-complication-of-pacemaker-implantation/
    Given otherwise negative workup, concomitant pleural and pericardial effusion were thought to be secondary to Dresslers syndrome in the setting of pacemaker implantation. […] Post-cardiac injury syndrome (PCIS) is a spectrum of disease presentations that can range from Dresslers pericarditis to pleuropericarditis. […] In studies of patients with PCIS, they commonly present with left sided, unilateral pleural effusions (83%). […] Our patient presents similarly to prior documented cases of PCIS following pacemaker implantation symptom onset was weeks from initial cardiac injury, and at that time had predominantly left sided exudative pleural effusion, and pericardial involvement.
  • #30
    https://homeopathyaajtak.in/diseases/d/dressler-s-syndrome-648
    Dressler’s syndrome is believed to be an immune system response after damage to heart tissue or to the pericardium, from events such as a heart attack, surgery or traumatic injury. […] Dressler’s syndrome is associated with an immune system response to heart damage. Your body reacts to the injured tissue by sending immune cells and proteins (antibodies) to clean up and repair the affected area. Sometimes this response causes excessive inflammation in the pericardium. […] The immune system response that leads to Dressler’s syndrome might also cause fluid to accumulate in the membranes around your lungs (pleural effusion).
  • #31 Dressler Syndrome (Postmyocardial Infarction Syndrome) – MD Searchlight
    https://mdsearchlight.com/heart-health/dressler-syndrome-postmyocardial-infarction-syndrome/
    The typical treatment is with non-steroidal anti-inflammatory drugs (NSAIDs) like aspirin, ibuprofen, or naproxen, which are gradually reduced over 4 to 6 weeks as the fluid around the heart decreases. […] Recurrences of Dressler syndrome are common, and patients may experience symptoms up to a year after the initial event.
  • #32 Dressler Syndrome (Postmyocardial Infarction Syndrome) – MD Searchlight
    https://mdsearchlight.com/heart-health/dressler-syndrome-postmyocardial-infarction-syndrome/?utm_source=pubmedlink&utm_campaign=MDS&utm_content=20700
    The typical treatment is with non-steroidal anti-inflammatory drugs (NSAIDs) like aspirin, ibuprofen, or naproxen, which are gradually reduced over 4 to 6 weeks as the fluid around the heart decreases. […] Recurrences of Dressler syndrome are common, and patients may experience symptoms up to a year after the initial event.
  • #33 Pericardial and Pleural Effusions After STEMI
    https://www.acc.org/Education-and-Meetings/Patient-Case-Quizzes/2022/03/07/13/30/Pericardial-and-Pleural-Effusions-After-STEMI
    Dr. William Dressler’s initial descriptions of „The Post Myocardial Infarction (MI) Syndrome” in the late 1950s catalogue a prolonged illness characterized by waxing and waning pleuritic chest pain, fevers, and an evanescent friction rub in the weeks following presentation with MI. The pathophysiology of Dressler syndrome was later elucidated to be autoimmune in nature, driven by an adaptive immune response against cardiac antigens released into the bloodstream during myocardial injury. […] This case illustrates a typical presentation of Dressler syndrome. Though it is rare, Dressler syndrome is important for the clinician to recognize. This patient’s presentation with enlarging pericardial and pleural effusions 2 weeks after suffering a STEMI is typical for Dressler syndrome. […] In our patient, no alternative cause was found, so both the pericardial and pleural effusions were caused by Dressler syndrome.