Materiały źródłowe

• #1 Nonalcoholic fatty liver disease (NAFLD) prevention: role of Mediterranean diet and physical activity

  https://pmc.ncbi.nlm.nih.gov/articles/PMC6503241/

  Nonalcoholic fatty liver disease (NAFLD) is one of the most common causes of chronic liver disease in Western countries leading to high morbidity and mortality and is strongly related to obesity. […] In order to decrease intrahepatic lipid (IHL) content and improve NAFLD, lifestyle interventions involving both diet and physical activity are recommended. […] In particular, great attention is focused on Mediterranean diet, which seems to help in gradually improving the severity of NAFLD. […] A randomized, cross-over intervention study demonstrated that in just 6 weeks, an olive-oil rich Mediterranean diet can result in a 40% relative reduction in liver fat measured by magnetic resonance in the form of IHL%. […] Mediterranean diet is characterized by a large intake of fruits, vegetables, whole grains, nuts, legumes and fish and low consumption of red meats with moderate alcohol intake, usually red wine consumed with meals.

• #2 Nonalcoholic fatty liver disease (NAFLD) prevention: role of Mediterranean diet and physical activity – Trovato – Hepatobiliary Surgery and Nutrition

  https://hbsn.amegroups.org/article/view/23080/html

  Nonalcoholic fatty liver disease (NAFLD) is one of the most common causes of chronic liver disease in Western countries leading to high morbidity and mortality and is strongly related to obesity. […] In order to decrease intrahepatic lipid (IHL) content and improve NAFLD, lifestyle interventions involving both diet and physical activity are recommended. […] In particular, great attention is focused on Mediterranean diet, which seems to help in gradually improving the severity of NAFLD. […] A very recent study by Ma and collaborators demonstrated that improved diet quality led to a decrease in liver fat accumulation and consequently a reduced risk and severity of steatosis in adults. […] Authors found that increased intake of fruits, legumes, vegetables, nuts, whole grains, eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and reduction in red meat and trans-fat, was associated with lower risk of steatosis.

• #3 Cardiovascular Risk in NAFLD | ECR Journal

  https://www.ecrjournal.com/articles/management-cardiovascular-risk-non-alcoholic-fatty-liver-disease-setting?language_content_entity=en

  Non-alcoholic fatty liver disease (NAFLD) is an overlooked and undetected pathology, which affects more than 32% of adults worldwide. […] Treatment options to counteract both the progression and development of cardiovascular disease and NAFLD include lifestyle interventions, such as weight loss, increased physical activity and dietary modification, and optimal medical therapy of comorbid conditions; nevertheless, further studies are needed to define optimal treatment strategies for the prevention of both hepatic and cardiovascular complications of NAFLD. […] Given the pandemic-level rise of NAFLD and its association with poor CV outcomes, the question of how to manage NAFLD successfully, in order to reduce the burden of associated incident CV events, is both timely and highly relevant.

• #4

  https://www.xiahepublishing.com/1555-3884/GE-2022-00005S

  Nonalcoholic fatty liver disease (NAFLD) prevention is critical before the development of disease-related complications. […] In this context, there is a tremendous substantial global burden on public health systems to actively search for effective preventive and therapeutic targets for NAFLD. […] Despite great efforts in finding pharmacological strategies for NAFLD prevention, nonpharmacological measures remain the first and critical issue for NAFLD prevention. Lifestyle modifications, including weight loss, dietary modifications, and exercise, also serve as a primary line of prevention. […] Energy intake restrictions, such as reduced saturated fat, carbohydrate, and sugar consumption, and an increase in consumption of green tea, coffee, and caffeine, could be beneficial dietary changes for NAFLD prevention.

• #5

  https://xiahepublishing.com/1555-3884/GE-2022-00005S

  Nonalcoholic fatty liver disease (NAFLD) prevention is critical before the development of disease-related complications. […] In this review, we highlight the current strategies to prevent progression and poor outcomes of NAFLD and to avoid complications associated with disease fibrosis, notably cirrhosis, portal hypertension, and liver cancer. […] Despite great efforts in finding pharmacological strategies for NAFLD prevention, nonpharmacological measures remain the first and critical issue for NAFLD prevention. Lifestyle modifications, including weight loss, dietary modifications, and exercise, also serve as a primary line of prevention. […] Energy intake restrictions, such as reduced saturated fat, carbohydrate, and sugar consumption, and an increase in consumption of green tea, coffee, and caffeine, could be beneficial dietary changes for NAFLD prevention.

• #6

  https://www.xiahepublishing.com/1555-3884/GE-2022-00005S

  Nonalcoholic fatty liver disease (NAFLD) prevention is critical before the development of disease-related complications. […] In this context, there is a tremendous substantial global burden on public health systems to actively search for effective preventive and therapeutic targets for NAFLD. […] Despite great efforts in finding pharmacological strategies for NAFLD prevention, nonpharmacological measures remain the first and critical issue for NAFLD prevention. Lifestyle modifications, including weight loss, dietary modifications, and exercise, also serve as a primary line of prevention. […] Energy intake restrictions, such as reduced saturated fat, carbohydrate, and sugar consumption, and an increase in consumption of green tea, coffee, and caffeine, could be beneficial dietary changes for NAFLD prevention.

• #7

  https://xiahepublishing.com/1555-3884/GE-2022-00005S

  Nonalcoholic fatty liver disease (NAFLD) prevention is critical before the development of disease-related complications. […] In this review, we highlight the current strategies to prevent progression and poor outcomes of NAFLD and to avoid complications associated with disease fibrosis, notably cirrhosis, portal hypertension, and liver cancer. […] Despite great efforts in finding pharmacological strategies for NAFLD prevention, nonpharmacological measures remain the first and critical issue for NAFLD prevention. Lifestyle modifications, including weight loss, dietary modifications, and exercise, also serve as a primary line of prevention. […] Energy intake restrictions, such as reduced saturated fat, carbohydrate, and sugar consumption, and an increase in consumption of green tea, coffee, and caffeine, could be beneficial dietary changes for NAFLD prevention.

• #8 Non-Alcoholic Fatty Liver Disease (NAFLD): Symptoms & Causes | NewYork-Presbyterian

  https://www.nyp.org/digestive/liver-diseases/fatty-liver-disease-non-alcoholic

  Preventing fatty liver disease is possible by following follow a healthy lifestyle that includes: […] Limiting or avoiding alcohol […] Maintaining a healthy weight […] Getting at least 30 minutes of exercise most days of the week […] Eating a nutrient-dense, healthy diet thats low in saturated fat, trans fat, and added sugars […] Managing blood sugar, triglyceride levels, and cholesterol levels […] Managing diabetes.

• #9 Nonalcoholic fatty liver disease – Diagnosis and treatment – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/nonalcoholic-fatty-liver-disease/diagnosis-treatment/drc-20354573

  Treatment for NAFLD usually starts with weight loss. This can be done by eating a healthy diet, limiting portion sizes and exercise. Losing weight may improve other health problems that lead to NAFLD. Typically, losing 10% of your body weight or more is recommended. But losing even 3% to 5% of your starting weight can have benefits. Weight-loss surgery or medicines also may be helpful for certain people. […] With help from your health care team, you can take steps to manage nonalcoholic fatty liver disease. You can: […] Lose weight. If you’re overweight or obese, reduce the number of calories you eat each day and increase your physical activity to lose weight slowly. Eating fewer calories is key to losing weight and managing this disease. If you tried to lose weight in the past and couldn’t, ask your health care team for help.

• #10 Liver – fatty liver disease | Better Health Channel

  https://www.betterhealth.vic.gov.au/health/conditionsandtreatments/liver-fatty-liver-disease

  Fatty liver disease is a build-up of fats in the liver that can damage the organ and lead to serious complications. […] In most cases, people with fatty liver disease are encouraged to modify their diets, take regular exercise and lose weight. […] There are no medical or surgical treatments for fatty liver, but some steps may help prevent or reverse some of the damage. In general, if you have fatty liver, and in particular if you have NASH, you should: lose weight safely. This usually means losing no more than half to one kilogram (one to two pounds) a week, lower your triglycerides through diet, medication or both, avoid alcohol, control your diabetes, if you have it, eat a balanced, healthy diet, increase your physical activity, get regular check-ups from a doctor who specialises in liver care.

• #11 Non-alcoholic fatty liver disease | Carr Lab | Perelman School of Medicine at the University of Pennsylvania

  https://www.med.upenn.edu/carr-lab/liver-disease.html

  Aby zapobiec ryzyku rozwoju niealkoholowej stłuszczeniowej choroby wątroby: […] W celu leczenia niealkoholowej stłuszczeniowej choroby wątroby: […] Obecnie zmiany stylu życia mogą złagodzić stłuszczenie. […] Utrata wagi jest najskuteczniejszym sposobem na zmniejszenie tłuszczu w wątrobie; utrata co najmniej 3 do 5 procent masy ciała może zmniejszyć tłuszcz w wątrobie […] Istnieją dowody, że utrata 10% masy ciała może być związana ze zmniejszeniem włóknienia wątroby. […] Dieta śródziemnomorska jest inną opcją leczenia NAFLD. […] Aktywność fizyczna jest również korzystna w redukcji tłuszczu w wątrobie i może być promowana u pacjentów, którzy mają trudności z modyfikacją diety i przestrzeganiem zaleceń dietetycznych. […] Dlatego połączenie ograniczenia kalorii oraz wzorca diety związanej z aktywnością fizyczną musi być brane pod uwagę w leczeniu NAFLD.

• #12 Nonalcoholic fatty liver disease – Diagnosis and treatment – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/nonalcoholic-fatty-liver-disease/diagnosis-treatment/drc-20354573

  Treatment for NAFLD usually starts with weight loss. This can be done by eating a healthy diet, limiting portion sizes and exercise. Losing weight may improve other health problems that lead to NAFLD. Typically, losing 10% of your body weight or more is recommended. But losing even 3% to 5% of your starting weight can have benefits. Weight-loss surgery or medicines also may be helpful for certain people. […] With help from your health care team, you can take steps to manage nonalcoholic fatty liver disease. You can: […] Lose weight. If you’re overweight or obese, reduce the number of calories you eat each day and increase your physical activity to lose weight slowly. Eating fewer calories is key to losing weight and managing this disease. If you tried to lose weight in the past and couldn’t, ask your health care team for help.

• #13 Nutrition & Nonalcoholic Fatty Liver Disease – Today’s Dietitian Magazine

  https://www.todaysdietitian.com/newarchives/0123p30.shtml

  Dietitians have a central role in prevention and treatment. […] Currently, nutrition and lifestyle interventions are the frontline treatments. […] Dietary and lifestyle interventions remain the first-line strategy in managing NAFLD and slowing or preventing its progression. […] Gradual weight loss of 3% to 5% of total body weight by creating a calorie deficit often is recommended to improve steatosis and prevent NAFL from progressing to NASH, but a weight loss of 7% to 10% may be needed to improve fibrosis and prevent NASH from becoming more severe. […] Physical activity has been shown to regulate liver fatincluding counterbalancing the adverse effects of overfeedingindependent of weight loss or overall adiposity, if the activity is habitual. […] To prevent or manage NAFLD, physical activity paired with a healthful diet are the primary options, pending successful clinical drug trials.

• #14 MASLD, NAFLD and fatty liver disease – British Liver Trust

  https://britishlivertrust.org.uk/information-and-support/liver-conditions/masld-nafld-and-fatty-liver-disease/

  Metabolic dysfunction-associated steatotic liver disease (MASLD) is a long-lasting liver condition caused by having too much fat in the liver. […] The main treatment is eating a well-balanced diet, being physically active and (if needed) losing weight. Research shows these can reduce liver fat and in some cases reverse MASLD. […] Treating MASLD with a healthy diet, physical activity and weight loss can slow or even reverse liver damage, especially if it is at an earlier stage. […] By eating healthily, doing plenty of physical activity and keeping your weight in a healthy range you have a good chance of repairing any damage and reversing your fatty liver disease. […] The main treatment is eating a healthy diet, being more physically active and (if needed) losing weight. This might seem like very general advice, but these steps all reduce liver fat and inflammation. For example, for people who are overweight, evidence shows losing 5 to 10% of their bodyweight can stop and sometimes even reverse liver damage.

• #15 Nutrition & Nonalcoholic Fatty Liver Disease – Today’s Dietitian Magazine

  https://www.todaysdietitian.com/newarchives/0123p30.shtml

  Dietitians have a central role in prevention and treatment. […] Currently, nutrition and lifestyle interventions are the frontline treatments. […] Dietary and lifestyle interventions remain the first-line strategy in managing NAFLD and slowing or preventing its progression. […] Gradual weight loss of 3% to 5% of total body weight by creating a calorie deficit often is recommended to improve steatosis and prevent NAFL from progressing to NASH, but a weight loss of 7% to 10% may be needed to improve fibrosis and prevent NASH from becoming more severe. […] Physical activity has been shown to regulate liver fatincluding counterbalancing the adverse effects of overfeedingindependent of weight loss or overall adiposity, if the activity is habitual. […] To prevent or manage NAFLD, physical activity paired with a healthful diet are the primary options, pending successful clinical drug trials.

• #16 Nonalcoholic Fatty Liver Disease: Common Questions and Answers on Diagnosis and Management | AAFP

  https://www.aafp.org/pubs/afp/issues/2020/1115/p603.html

  Nonalcoholic fatty liver disease (NAFLD) is the most common form of liver disease in the United States, affecting up to 30% of adults. […] Weight loss through diet and exercise is the primary treatment for NAFLD. […] Routine screening for NAFLD is not recommended, even in high-risk adults. […] Patients with hepatic steatosis detected incidentally on imaging who have normal liver enzyme findings and no liver-related symptoms or signs should be assessed for metabolic risk factors (e.g., obesity, diabetes mellitus, dyslipidemia) and alternate causes of hepatic steatosis, such as excessive alcohol consumption or medication use. […] Liver biopsy should be considered for patients at increased risk of fibrosis and when other liver disorders cannot be excluded with noninvasive tests. […] A loss of 7% to 10% of total body weight is needed to improve the histopathologic abnormalities in the liver associated with NAFLD.

• #17 Non-alcoholic fatty liver disease | Carr Lab | Perelman School of Medicine at the University of Pennsylvania

  https://www.med.upenn.edu/carr-lab/liver-disease.html

  Aby zapobiec ryzyku rozwoju niealkoholowej stłuszczeniowej choroby wątroby: […] W celu leczenia niealkoholowej stłuszczeniowej choroby wątroby: […] Obecnie zmiany stylu życia mogą złagodzić stłuszczenie. […] Utrata wagi jest najskuteczniejszym sposobem na zmniejszenie tłuszczu w wątrobie; utrata co najmniej 3 do 5 procent masy ciała może zmniejszyć tłuszcz w wątrobie […] Istnieją dowody, że utrata 10% masy ciała może być związana ze zmniejszeniem włóknienia wątroby. […] Dieta śródziemnomorska jest inną opcją leczenia NAFLD. […] Aktywność fizyczna jest również korzystna w redukcji tłuszczu w wątrobie i może być promowana u pacjentów, którzy mają trudności z modyfikacją diety i przestrzeganiem zaleceń dietetycznych. […] Dlatego połączenie ograniczenia kalorii oraz wzorca diety związanej z aktywnością fizyczną musi być brane pod uwagę w leczeniu NAFLD.

• #18 Is fatty liver disease reversible? Research and more

  https://www.medicalnewstoday.com/articles/is-fatty-liver-reversible

  While there is no treatment for fatty liver disease, certain lifestyle changes may help reverse the condition in its early stages. Avoiding alcohol and eating a balanced diet may help. […] According to a 2023 overview of research, NAFLD is a slowly progressive condition that is reversible at its early stage, which doctors call steatosis, or simple fatty liver. […] Additionally, the NHS notes that early detection and management may help reduce the amount of liver fat and stop NAFLD from progressing to end stage liver damage. […] A 2018 study indicates that lifestyle and diet modifications that lead to a 10% loss of total body weight may benefit over 90% of people with NASH by preventing the progression to liver fibrosis. […] According to a 2022 systematic review, lifestyle modifications are usually the first line of treatment for NAFLD.

• #19 Cardiovascular Risk in NAFLD | ECR Journal

  https://www.ecrjournal.com/articles/management-cardiovascular-risk-non-alcoholic-fatty-liver-disease-setting?language_content_entity=en

  A tailored multistep treatment approach has been proposed for the management of NAFLD as an effective tool to reduce the risk of CV disease in these patients. […] Lifestyle intervention is the key therapeutic intervention for patients with NAFLD. […] Dietary modification, increased physical activity, weight loss and alcohol avoidance are strongly recommended. […] Currently, weight loss is the most effective treatment for NAFLD, even in the minority of patients with NAFLD who do not have obesity, and is recommended in all guidelines. […] Even modest weight loss (5-10%) is associated with significant benefits. […] A systematic review and meta-analysis was performed to compare the impact of Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG) on NAFLD and NASH. […] The authors concluded that SG and RYGB were equivalently effective for treating NAFLD and NASH.

• #20 Non-alcoholic fatty liver disease: a practical approach to treatment | Frontline Gastroenterology

  https://fg.bmj.com/content/5/4/277

  The optimum diet to treat NAFLD is not known. Until further evidence is available, a calorie restricted diet (600Kcal less than a person needs to remain at the same weight) should be recommended aiming to lose 0.51kg per week until the target weight is achieved. […] Bariatric surgery has an increasing role in the management of patients with obesity and the metabolic syndrome. […] For patients with biopsy-proven NASH, where lifestyle intervention has failed, liver-directed pharmacotherapy with pioglitazone or vitamin E can be considered. […] Approximately 40%50% of patients with NAFLD attending secondary care clinics have T2DM and the majority have evidence of insulin resistance. […] Effective treatment of dyslipidaemias is vital in the management of NAFLD to reduce patients cardiovascular risk profile. […] Lifestyle interventions aimed at weight loss and increased activity are essential for all patients with NAFLD and if sustained are effective in the treatment of NAFLD.

• #21 Liver Health: Prevention & Treatment of Non-Alcoholic Fatty Liver Disease

  https://gidoc.co.za/liver-health-prevention-treatment-non-alcoholic-fatty-liver-disease/

  Preventing NAFLD involves adopting a healthy lifestyle and addressing modifiable risk factors. Here are some key strategies: […] Maintain a Healthy Weight […] Achieve and Maintain a Healthy BMI: Aim for a body mass index (BMI) within the healthy range (18.5-24.9). […] Gradual Weight Loss: Avoid rapid weight loss, as it can exacerbate liver inflammation. Aim for a gradual weight loss of 1-2 pounds per week. […] Adopt a Balanced Diet […] Mediterranean Diet: Emphasize whole grains, lean proteins, healthy fats (such as olive oil), and plenty of fruits and vegetables. […] Reduce Sugar Intake: Limit consumption of sugary beverages, desserts, and snacks. Opt for natural sweeteners like honey and fruit. […] Avoid Trans Fats: Minimize intake of trans fats found in processed and fried foods.

• #22 Non-alcoholic fatty liver disease: a practical approach to treatment | Frontline Gastroenterology

  https://fg.bmj.com/content/5/4/277

  The optimum diet to treat NAFLD is not known. Until further evidence is available, a calorie restricted diet (600Kcal less than a person needs to remain at the same weight) should be recommended aiming to lose 0.51kg per week until the target weight is achieved. […] Bariatric surgery has an increasing role in the management of patients with obesity and the metabolic syndrome. […] For patients with biopsy-proven NASH, where lifestyle intervention has failed, liver-directed pharmacotherapy with pioglitazone or vitamin E can be considered. […] Approximately 40%50% of patients with NAFLD attending secondary care clinics have T2DM and the majority have evidence of insulin resistance. […] Effective treatment of dyslipidaemias is vital in the management of NAFLD to reduce patients cardiovascular risk profile. […] Lifestyle interventions aimed at weight loss and increased activity are essential for all patients with NAFLD and if sustained are effective in the treatment of NAFLD.

• #23 Nonalcoholic fatty liver disease – Diagnosis and treatment – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/nonalcoholic-fatty-liver-disease/diagnosis-treatment/drc-20354573

  Choose a healthy diet. Eat a healthy diet that’s rich in fruits, vegetables and whole grains. Your health care team may suggest avoiding or limiting certain foods and drinks, such as white bread, red and processed meats, juices, and sweetened drinks. Keep track of all calories you take in. […] Exercise and be more active. Aim for at least 150 minutes of exercise a week. If you’re trying to lose weight, you might find that more exercise is helpful. But if you don’t already exercise regularly, get your health care team’s OK first and start slowly. […] Manage your diabetes. Follow your health care team’s advice to manage your diabetes. Take your medicines as told by your care team and watch your blood sugar closely. […] Lower your cholesterol and blood pressure. Improve your cholesterol levels and blood pressure if they are high. A healthy diet, exercise and medicines can help keep your cholesterol, triglycerides and blood pressure at healthy levels. […] Protect your liver. Avoid things that could harm your liver health. For example, don’t drink alcohol. Follow the instructions on all medicines and nonprescription drugs. Check with your health care team before using any herbal supplements, as some can harm the liver.

• #24 Nutrition & Nonalcoholic Fatty Liver Disease – Today’s Dietitian Magazine

  https://www.todaysdietitian.com/newarchives/0123p30.shtml

  An analysis of data from the 20172018 cycle of the NHANES for 3,900 US adults aged 18 or older found that a healthful, plant-based diet was associated with lower odds of having NAFLD. […] Multiple studies have found benefits from Mediterranean-type diets in managing NAFLD. […] For dietitians working with clients and patients with NAFLD, or who have high risk of developing it, the most evidence-based nutrition and lifestyle interventions at this time include helping patients do the following: Reduce dietary fat to 30% of daily calories, replacing saturated fats and trans fats in the diet with unsaturated fats from nuts, seeds, avocados, olives, and olive oil, and especially with omega-3 fatty acids from fish, walnuts, flax, and chia seeds. […] Limit carbohydrates to 50% of daily calories, and emphasize low-glycemic, high-fiber carbohydrates such as vegetables, whole grains, legumes, and most fruits.

• #25 Nonalcoholic fatty liver disease (NAFLD) prevention: role of Mediterranean diet and physical activity

  https://pmc.ncbi.nlm.nih.gov/articles/PMC6503241/

  Nonalcoholic fatty liver disease (NAFLD) is one of the most common causes of chronic liver disease in Western countries leading to high morbidity and mortality and is strongly related to obesity. […] In order to decrease intrahepatic lipid (IHL) content and improve NAFLD, lifestyle interventions involving both diet and physical activity are recommended. […] In particular, great attention is focused on Mediterranean diet, which seems to help in gradually improving the severity of NAFLD. […] A randomized, cross-over intervention study demonstrated that in just 6 weeks, an olive-oil rich Mediterranean diet can result in a 40% relative reduction in liver fat measured by magnetic resonance in the form of IHL%. […] Mediterranean diet is characterized by a large intake of fruits, vegetables, whole grains, nuts, legumes and fish and low consumption of red meats with moderate alcohol intake, usually red wine consumed with meals.

• #26 Dietary patterns in non-alcoholic fatty liver disease (NAFLD): Stay on the straight and narrow path! | Clínica e Investigación en Arteriosclerosis

  https://www.elsevier.es/es-revista-clinica-e-investigacion-arteriosclerosis-15-articulo-dietary-patterns-in-non-alcoholic-fatty-S0214916821001558

  Nevertheless, there is no one-size-fits-all dietary intervention for NAFLD management. Clinicians should discuss with their patients and define the diet that each individual prefers and is able to implement in his/her daily life. […] Based on the above, MedDiet is recommended in individuals with NAFLD/NASH, since it can improve both liver steatosis and several CV risk factors, thus also protecting from CV morbidity/mortality. […] Overall, the MedDiet is superior to other diets in preventing/treating NAFLD/NASH, as well as MetS and its components, T2D and CVD. […] Therefore, it is recommended as the diet of choice for the prevention/treatment of NAFLD/NASH and its complications. […] Currently, diet-induced weight loss is regarded as the first therapeutic approach in NAFLD/NASH to resolve steatosis and reverse fibrosis. Plant-based dietary patterns, poor in saturated fat, refined carbohydrates, red and processed meats, are preferred, including the Mediterranean, DASH and vegetarian/vegan diets.

• #27 Nonalcoholic fatty liver disease (NAFLD) prevention: role of Mediterranean diet and physical activity

  https://pmc.ncbi.nlm.nih.gov/articles/PMC6503241/

  Nonalcoholic fatty liver disease (NAFLD) is one of the most common causes of chronic liver disease in Western countries leading to high morbidity and mortality and is strongly related to obesity. […] In order to decrease intrahepatic lipid (IHL) content and improve NAFLD, lifestyle interventions involving both diet and physical activity are recommended. […] In particular, great attention is focused on Mediterranean diet, which seems to help in gradually improving the severity of NAFLD. […] A randomized, cross-over intervention study demonstrated that in just 6 weeks, an olive-oil rich Mediterranean diet can result in a 40% relative reduction in liver fat measured by magnetic resonance in the form of IHL%. […] Mediterranean diet is characterized by a large intake of fruits, vegetables, whole grains, nuts, legumes and fish and low consumption of red meats with moderate alcohol intake, usually red wine consumed with meals.

• #28 Nonalcoholic fatty liver disease (NAFLD) prevention: role of Mediterranean diet and physical activity

  https://pmc.ncbi.nlm.nih.gov/articles/PMC6503241/

  Nonalcoholic fatty liver disease (NAFLD) is one of the most common causes of chronic liver disease in Western countries leading to high morbidity and mortality and is strongly related to obesity. […] In order to decrease intrahepatic lipid (IHL) content and improve NAFLD, lifestyle interventions involving both diet and physical activity are recommended. […] In particular, great attention is focused on Mediterranean diet, which seems to help in gradually improving the severity of NAFLD. […] A randomized, cross-over intervention study demonstrated that in just 6 weeks, an olive-oil rich Mediterranean diet can result in a 40% relative reduction in liver fat measured by magnetic resonance in the form of IHL%. […] Mediterranean diet is characterized by a large intake of fruits, vegetables, whole grains, nuts, legumes and fish and low consumption of red meats with moderate alcohol intake, usually red wine consumed with meals.

• #29 Nutrition could prevent or promote non-alcoholic fatty liver disease: an opportunity for intervention | The BMJ

  https://www.bmj.com/content/383/bmj-2023-075179

  The Mediterranean diet (rich in vegetables, fruit, beans, lentils nuts, whole grains, and fish) can reduce the risk of NAFLD and improve cardiometabolic health, as well as manage the effects of NAFLD in patients. […] Growing evidence suggests that the DASH (dietary approaches to stop hypertension) diet contributes to reduced NAFLD risk. […] A healthy lifestyle reduces the risk of developing NAFLD and could also promote NAFLD regression. […] Tackling NAFLD necessitates a multifaceted approach requiring collaboration across governments, healthcare institutions, communities, families, and individuals.

• #30 Nutrition could prevent or promote non-alcoholic fatty liver disease: an opportunity for intervention | The BMJ

  https://www.bmj.com/content/383/bmj-2023-075179

  The Mediterranean diet (rich in vegetables, fruit, beans, lentils nuts, whole grains, and fish) can reduce the risk of NAFLD and improve cardiometabolic health, as well as manage the effects of NAFLD in patients. […] Growing evidence suggests that the DASH (dietary approaches to stop hypertension) diet contributes to reduced NAFLD risk. […] A healthy lifestyle reduces the risk of developing NAFLD and could also promote NAFLD regression. […] Tackling NAFLD necessitates a multifaceted approach requiring collaboration across governments, healthcare institutions, communities, families, and individuals.

• #31

  https://www.xiahepublishing.com/1555-3884/GE-2022-00005S

  Nonalcoholic fatty liver disease (NAFLD) prevention is critical before the development of disease-related complications. […] In this context, there is a tremendous substantial global burden on public health systems to actively search for effective preventive and therapeutic targets for NAFLD. […] Despite great efforts in finding pharmacological strategies for NAFLD prevention, nonpharmacological measures remain the first and critical issue for NAFLD prevention. Lifestyle modifications, including weight loss, dietary modifications, and exercise, also serve as a primary line of prevention. […] Energy intake restrictions, such as reduced saturated fat, carbohydrate, and sugar consumption, and an increase in consumption of green tea, coffee, and caffeine, could be beneficial dietary changes for NAFLD prevention.

• #32 Nutrition & Nonalcoholic Fatty Liver Disease – Today’s Dietitian Magazine

  https://www.todaysdietitian.com/newarchives/0123p30.shtml

  An analysis of data from the 20172018 cycle of the NHANES for 3,900 US adults aged 18 or older found that a healthful, plant-based diet was associated with lower odds of having NAFLD. […] Multiple studies have found benefits from Mediterranean-type diets in managing NAFLD. […] For dietitians working with clients and patients with NAFLD, or who have high risk of developing it, the most evidence-based nutrition and lifestyle interventions at this time include helping patients do the following: Reduce dietary fat to 30% of daily calories, replacing saturated fats and trans fats in the diet with unsaturated fats from nuts, seeds, avocados, olives, and olive oil, and especially with omega-3 fatty acids from fish, walnuts, flax, and chia seeds. […] Limit carbohydrates to 50% of daily calories, and emphasize low-glycemic, high-fiber carbohydrates such as vegetables, whole grains, legumes, and most fruits.

• #33

  https://www.xiahepublishing.com/1555-3884/GE-2022-00005S

  Nonalcoholic fatty liver disease (NAFLD) prevention is critical before the development of disease-related complications. […] In this context, there is a tremendous substantial global burden on public health systems to actively search for effective preventive and therapeutic targets for NAFLD. […] Despite great efforts in finding pharmacological strategies for NAFLD prevention, nonpharmacological measures remain the first and critical issue for NAFLD prevention. Lifestyle modifications, including weight loss, dietary modifications, and exercise, also serve as a primary line of prevention. […] Energy intake restrictions, such as reduced saturated fat, carbohydrate, and sugar consumption, and an increase in consumption of green tea, coffee, and caffeine, could be beneficial dietary changes for NAFLD prevention.

• #34 Non-alcoholic fatty liver disease-related hepatocellular carcinoma

  https://www.e-jlc.org/journal/view.php?number=514

  Amongst patients with diabetes, treatment with thiazolidinediones and metformin have also been associated with significant reductions in HCC risk. […] Statins may serve as another method of chemoprevention, with a meta-analysis of 24 studies (n=59,073 patients) demonstrating decreased HCC risk by 46%. […] Coffee has also shown promising results. A meta-analysis of 13 prospective cohort and case-control studies showed that increasing coffee consumption by one cup daily was associated with 15% HCC risk reduction.

• #35 Nonalcoholic fatty liver disease (NAFLD) prevention: role of Mediterranean diet and physical activity

  https://pmc.ncbi.nlm.nih.gov/articles/PMC6503241/

  Authors found that increased intake of fruits, legumes, vegetables, nuts, whole grains, eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and reduction in red meat and trans-fat, was associated with lower risk of steatosis. […] Moreover, high fiber consumption increases bacteria degrading fiber which may increase the production of short-chain fatty acids (SCFAs), including butyrate which may suppress inflammation reducing the possible onset and progression of NAFLD. […] Together with diet, physical activity is suggested in NAFLD prevention and treatment, data from literature reported that physical activity influences hepatic metabolism and is inversely associated with the onset of NAFLD and NASH. […] Exercise training induces significant improvement of hepatic and visceral fat accumulation, increased lipid oxidation and insulin sensitivity.

• #36 Nonalcoholic fatty liver disease (NAFLD) prevention: role of Mediterranean diet and physical activity – Trovato – Hepatobiliary Surgery and Nutrition

  https://hbsn.amegroups.org/article/view/23080/html

  Nonalcoholic fatty liver disease (NAFLD) is one of the most common causes of chronic liver disease in Western countries leading to high morbidity and mortality and is strongly related to obesity. […] In order to decrease intrahepatic lipid (IHL) content and improve NAFLD, lifestyle interventions involving both diet and physical activity are recommended. […] In particular, great attention is focused on Mediterranean diet, which seems to help in gradually improving the severity of NAFLD. […] A very recent study by Ma and collaborators demonstrated that improved diet quality led to a decrease in liver fat accumulation and consequently a reduced risk and severity of steatosis in adults. […] Authors found that increased intake of fruits, legumes, vegetables, nuts, whole grains, eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and reduction in red meat and trans-fat, was associated with lower risk of steatosis.

• #37 Nonalcoholic fatty liver disease (NAFLD) prevention: role of Mediterranean diet and physical activity

  https://pmc.ncbi.nlm.nih.gov/articles/PMC6503241/

  Authors found that increased intake of fruits, legumes, vegetables, nuts, whole grains, eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and reduction in red meat and trans-fat, was associated with lower risk of steatosis. […] Moreover, high fiber consumption increases bacteria degrading fiber which may increase the production of short-chain fatty acids (SCFAs), including butyrate which may suppress inflammation reducing the possible onset and progression of NAFLD. […] Together with diet, physical activity is suggested in NAFLD prevention and treatment, data from literature reported that physical activity influences hepatic metabolism and is inversely associated with the onset of NAFLD and NASH. […] Exercise training induces significant improvement of hepatic and visceral fat accumulation, increased lipid oxidation and insulin sensitivity.

• #38 Fatty Liver Diet: What Foods to Eat and What Foods to Avoid

  https://www.healthline.com/health/fatty-liver-diet

  Following a well-rounded, nutritious diet rich in fiber, lean or plant-based protein, and healthy fats is the best way to improve liver health, lower disease risk, and promote healthy weight loss. […] Fatty liver disease damages the liver and prevents it from working as well as it should, but lifestyle changes can prevent it from getting worse. […] The first line of treatment for overweight or obese individuals with NAFLD is gradual weight loss through a combination of calorie reduction, exercise, and healthy eating. […] A nutrient-dense, whole-food-based diet rich in fiber, protein, and unsaturated fats is generally recommended for people with NAFLD. […] Research suggests that supplementing with omega-3s may benefit those with NAFLD by reducing liver fat, boosting protective HDL cholesterol, and lowering triglyceride levels.

• #39 Mediterranean diet and the prevention of non-alcoholic fatty liver disease: results from a case-control study

  https://www.europeanreview.org/article/21907

  Few studies report that Mediterranean dietary (MD) pattern has a beneficial role in the progression of non-alcoholic fatty liver disease (NAFLD). […] Our study shows that a high adherence to the MD decreases the risk of NAFLD. […] A high adherence to the MD is significantly associated with decreased risk of NAFLD (OR: 0.83 95% CI: 0.71-0.98). […] Higher legumes consumption (OR: 0.62 95% CI: 0.38-0.99) and high fish consumption (OR 0.38 95% CI: 0.17-0.85) were reported to be protective against NAFLD.

• #40 Nonalcoholic fatty liver disease (NAFLD) prevention: role of Mediterranean diet and physical activity

  https://pmc.ncbi.nlm.nih.gov/articles/PMC6503241/

  Authors found that increased intake of fruits, legumes, vegetables, nuts, whole grains, eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and reduction in red meat and trans-fat, was associated with lower risk of steatosis. […] Moreover, high fiber consumption increases bacteria degrading fiber which may increase the production of short-chain fatty acids (SCFAs), including butyrate which may suppress inflammation reducing the possible onset and progression of NAFLD. […] Together with diet, physical activity is suggested in NAFLD prevention and treatment, data from literature reported that physical activity influences hepatic metabolism and is inversely associated with the onset of NAFLD and NASH. […] Exercise training induces significant improvement of hepatic and visceral fat accumulation, increased lipid oxidation and insulin sensitivity.

• #41

  https://www.xiahepublishing.com/1555-3884/GE-2022-00005S

  A lack of physical activity is associated with an increased risk of NAFLD; the lower the level of habitual physical activity the greater the risk of intrahepatic fat content. […] Weight loss can have a significant impact on overweight or obese NAFLD patients. […] Proper sleep patterns and duration combined with other behavioral factors are important in NAFLD prevention. […] Bariatric surgery represents an alternative nonpharmacological management option for obese patients with NAFLD. […] Microbial metabolic manipulation via the microbiome and its metabolites could represent a potential option for NAFLD prevention, but more extensive research is required. […] Pharmacological therapies have had significant effects on NAFLD prevention, especially for patients in high-risk groups, such as those with concomitant T2DM. […] NAFLD prevention is important before the development of disease-related complications.

• #42

  https://www.xiahepublishing.com/1555-3884/GE-2022-00005S

  A lack of physical activity is associated with an increased risk of NAFLD; the lower the level of habitual physical activity the greater the risk of intrahepatic fat content. […] Weight loss can have a significant impact on overweight or obese NAFLD patients. […] Proper sleep patterns and duration combined with other behavioral factors are important in NAFLD prevention. […] Bariatric surgery represents an alternative nonpharmacological management option for obese patients with NAFLD. […] Microbial metabolic manipulation via the microbiome and its metabolites could represent a potential option for NAFLD prevention, but more extensive research is required. […] Pharmacological therapies have had significant effects on NAFLD prevention, especially for patients in high-risk groups, such as those with concomitant T2DM. […] NAFLD prevention is important before the development of disease-related complications.

• #43

  https://xiahepublishing.com/1555-3884/GE-2022-00005S

  A lack of physical activity is associated with an increased risk of NAFLD; the lower the level of habitual physical activity the greater the risk of intrahepatic fat content. […] Weight loss can have a significant impact on overweight or obese NAFLD patients. […] Proper sleep patterns and duration combined with other behavioral factors are important in NAFLD prevention. […] Due to the superior efficacy of sustained weight loss and physical activity in NAFLD prevention, bariatric surgery represents an alternative nonpharmacological management option for obese patients with NAFLD. […] Microbial metabolic manipulation via the microbiome and its metabolites could represent a potential option for NAFLD prevention, but more extensive research is required. […] Many efforts are being made toward NAFLD prevention and management, mainly through controlling the modifiable predisposing risk factors, with many pharmacological agents still under investigation.

• #44 Nonalcoholic fatty liver disease (NAFLD) prevention: role of Mediterranean diet and physical activity

  https://pmc.ncbi.nlm.nih.gov/articles/PMC6503241/

  Authors found that increased intake of fruits, legumes, vegetables, nuts, whole grains, eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and reduction in red meat and trans-fat, was associated with lower risk of steatosis. […] Moreover, high fiber consumption increases bacteria degrading fiber which may increase the production of short-chain fatty acids (SCFAs), including butyrate which may suppress inflammation reducing the possible onset and progression of NAFLD. […] Together with diet, physical activity is suggested in NAFLD prevention and treatment, data from literature reported that physical activity influences hepatic metabolism and is inversely associated with the onset of NAFLD and NASH. […] Exercise training induces significant improvement of hepatic and visceral fat accumulation, increased lipid oxidation and insulin sensitivity.

• #45 Nonalcoholic fatty liver disease (NAFLD) prevention: role of Mediterranean diet and physical activity – Trovato – Hepatobiliary Surgery and Nutrition

  https://hbsn.amegroups.org/article/view/23080/html

  Mediterranean diet interventions in non-Mediterranean countries may have additional challenges and need specific approaches. […] Together with diet, physical activity is suggested in NAFLD prevention and treatment, data from literature reported that physical activity influences hepatic metabolism and is inversely associated with the onset of NAFLD and NASH. […] Even if a large number of studies support the efficacy of both diet-based approaches and physical activity for NAFLD prevention, further future investigations are needed to confirm scientific data and to explore the possible molecular mechanisms underlying the association between NAFLD, diet and physical activity.

• #46 Nonalcoholic fatty liver disease (NAFLD) prevention: role of Mediterranean diet and physical activity

  https://pmc.ncbi.nlm.nih.gov/articles/PMC6503241/

  Authors found that increased intake of fruits, legumes, vegetables, nuts, whole grains, eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and reduction in red meat and trans-fat, was associated with lower risk of steatosis. […] Moreover, high fiber consumption increases bacteria degrading fiber which may increase the production of short-chain fatty acids (SCFAs), including butyrate which may suppress inflammation reducing the possible onset and progression of NAFLD. […] Together with diet, physical activity is suggested in NAFLD prevention and treatment, data from literature reported that physical activity influences hepatic metabolism and is inversely associated with the onset of NAFLD and NASH. […] Exercise training induces significant improvement of hepatic and visceral fat accumulation, increased lipid oxidation and insulin sensitivity.

• #47 Nonalcoholic fatty liver disease – Diagnosis and treatment – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/nonalcoholic-fatty-liver-disease/diagnosis-treatment/drc-20354573

  Choose a healthy diet. Eat a healthy diet that’s rich in fruits, vegetables and whole grains. Your health care team may suggest avoiding or limiting certain foods and drinks, such as white bread, red and processed meats, juices, and sweetened drinks. Keep track of all calories you take in. […] Exercise and be more active. Aim for at least 150 minutes of exercise a week. If you’re trying to lose weight, you might find that more exercise is helpful. But if you don’t already exercise regularly, get your health care team’s OK first and start slowly. […] Manage your diabetes. Follow your health care team’s advice to manage your diabetes. Take your medicines as told by your care team and watch your blood sugar closely. […] Lower your cholesterol and blood pressure. Improve your cholesterol levels and blood pressure if they are high. A healthy diet, exercise and medicines can help keep your cholesterol, triglycerides and blood pressure at healthy levels. […] Protect your liver. Avoid things that could harm your liver health. For example, don’t drink alcohol. Follow the instructions on all medicines and nonprescription drugs. Check with your health care team before using any herbal supplements, as some can harm the liver.

• #48 Managing Fatty Liver: Prevention and Treatment  | M3 Wake Research

  https://wakeresearch.com/about-us/news-updates/managing-fatty-liver-prevention-and-treatment/

  While fatty liver disease is a serious health issue, it can often be prevented and managed with lifestyle changes. […] Early diagnosis and intervention are important for managing fatty liver effectively and preventing its progression to more severe complications. Lifestyle changes, such as maintaining a healthy weight, engaging in regular physical activity, and eating a balanced diet, can help those with fatty liver improve their liver health and prevent further damage. […] By adopting healthy lifestyle habits, we can significantly reduce our risk and promote overall well-being: […] Develop healthy eating habits and regular physical activity to achieve and maintain a healthy body weight. Even smaller amounts of weight loss (5-10% of body weight) can improve liver health. […] Try getting at least 150 minutes of moderate-intensity exercise or 75 minutes of high-intensity exercise each week. Taking part in any form of physical activity is great, so look for activities you enjoy and incorporate them into your daily routine. […] By making a few changes now, avoiding the negative effects of our modern lifestyle and keeping your liver healthy is possible. Remember, taking charge of your health can have a big impact on your long-term well-being.

• #49 Nutrition & Nonalcoholic Fatty Liver Disease – Today’s Dietitian Magazine

  https://www.todaysdietitian.com/newarchives/0123p30.shtml

  Dietitians have a central role in prevention and treatment. […] Currently, nutrition and lifestyle interventions are the frontline treatments. […] Dietary and lifestyle interventions remain the first-line strategy in managing NAFLD and slowing or preventing its progression. […] Gradual weight loss of 3% to 5% of total body weight by creating a calorie deficit often is recommended to improve steatosis and prevent NAFL from progressing to NASH, but a weight loss of 7% to 10% may be needed to improve fibrosis and prevent NASH from becoming more severe. […] Physical activity has been shown to regulate liver fatincluding counterbalancing the adverse effects of overfeedingindependent of weight loss or overall adiposity, if the activity is habitual. […] To prevent or manage NAFLD, physical activity paired with a healthful diet are the primary options, pending successful clinical drug trials.

• #50 Liver Health: Prevention & Treatment of Non-Alcoholic Fatty Liver Disease

  https://gidoc.co.za/liver-health-prevention-treatment-non-alcoholic-fatty-liver-disease/

  Increase Fiber Intake: Incorporate fiber-rich foods like legumes, whole grains, and vegetables to improve digestion and reduce fat absorption. […] Regular Physical Activity […] Aerobic Exercise: Engage in at least 150 minutes of moderate-intensity aerobic exercise, such as brisk walking, swimming, or cycling, each week. […] Strength Training: Include resistance exercises at least two days per week to build muscle mass and improve metabolism. […] Stay Active: Incorporate more physical activity into daily routines, such as taking the stairs, walking during breaks, and reducing sedentary time. […] Monitor and Manage Health Conditions […] Control Blood Sugar Levels: If you have diabetes, monitor blood glucose levels and follow a diabetic-friendly diet. […] Manage Blood Pressure: Maintain a healthy blood pressure through lifestyle changes and, if necessary, medication.

• #51 Nonalcoholic Fatty Liver Disease: Diagnosis and Management | AAFP

  https://www.aafp.org/pubs/afp/issues/2013/0701/p35.html

  A healthy diet, weight loss, and exercise are first-line therapeutic measures to reduce insulin resistance in patients with nonalcoholic fatty liver disease. […] There are no specific studies addressing the prevention of nonalcoholic fatty liver disease; however, because obesity and physical inactivity are strongly correlated with the condition, it is reasonable to expect that increasing physical activity and encouraging weight loss would be helpful. […] Patients with nonalcoholic fatty liver disease should be immunized for hepatitis A and B, and be encouraged to limit alcohol use to prevent the development of alcohol-induced liver disease.

• #52 Liver Health: Prevention & Treatment of Non-Alcoholic Fatty Liver Disease

  https://gidoc.co.za/liver-health-prevention-treatment-non-alcoholic-fatty-liver-disease/

  Increase Fiber Intake: Incorporate fiber-rich foods like legumes, whole grains, and vegetables to improve digestion and reduce fat absorption. […] Regular Physical Activity […] Aerobic Exercise: Engage in at least 150 minutes of moderate-intensity aerobic exercise, such as brisk walking, swimming, or cycling, each week. […] Strength Training: Include resistance exercises at least two days per week to build muscle mass and improve metabolism. […] Stay Active: Incorporate more physical activity into daily routines, such as taking the stairs, walking during breaks, and reducing sedentary time. […] Monitor and Manage Health Conditions […] Control Blood Sugar Levels: If you have diabetes, monitor blood glucose levels and follow a diabetic-friendly diet. […] Manage Blood Pressure: Maintain a healthy blood pressure through lifestyle changes and, if necessary, medication.

• #53 Non-alcoholic fatty liver disease (NAFLD)

  https://www.nhs.uk/conditions/non-alcoholic-fatty-liver-disease/

  Non-alcoholic fatty liver disease (NAFLD) is the term for a range of conditions caused by a build-up of fat in the liver. It’s important to make lifestyle changes to prevent the condition getting worse. If detected and managed at an early stage, it’s possible to stop NAFLD getting worse and reduce the amount of fat in your liver. Most people with NAFLD will not develop any serious problems, but if you’re diagnosed with the condition it’s a good idea to take steps to stop it getting any worse. Adopting a healthy lifestyle is the main way of managing NAFLD. For example, it can help to: lose weight you should aim for a BMI of 18.5 to 24.9; eating smaller portions of food can help, too […] NAFLD is not caused by alcohol, but drinking may make it worse. It’s therefore advisable to cut down or stop drinking alcohol.

• #54 4 Nonalcoholic Fatty Liver Disease Treatments

  https://www.aarp.org/health/conditions-treatments/reverse-nonalcoholic-fatty-liver-disease/

  Exercise plays a role in any weight loss plan of course but research suggests it plays a specific role in reversing NAFLD that has nothing to do with losing weight. […] A study published in Gastroenterology found that alcohol significantly impacts disease progression in other forms of liver disease, including NASH. […] We’re starting to move toward the recommendation that there is no safe amount of alcohol, says Rinella, a coauthor of the study.

• #55 Nonalcoholic Fatty Liver Disease (NAFLD)

  https://liverfoundation.org/liver-diseases/fatty-liver-disease/nonalcoholic-fatty-liver-disease-nafld/

  Nonalcoholic fatty liver disease (NAFLD), now called metabolic dysfunction-associated steatotic liver disease (MASLD), is the buildup of extra fat in liver cells that is not caused by alcohol. […] There are things people can do to lower their chances of developing NAFLD (now called MASLD). They include: Maintain a healthy weight. Eat meals that contain lean proteins, whole grains, fruits, vegetables, healthy oils, and low-fat dairy products. Try to include some kind of physical movement during most days of the week. If you are not currently physically active, speak with your doctor about the types of activities you can do that are safe for your current physical abilities. Limit or avoid alcohol intake. Only take medicines that you need and follow dosing recommendations. […] Early diagnosis of NAFLD, along with following medical advice, can reduce a persons chance NAFLD progressing to NASH and cirrhosis.

• #56 Nonalcoholic Fatty Liver Disease: Diagnosis and Management | AAFP

  https://www.aafp.org/pubs/afp/issues/2013/0701/p35.html

  A healthy diet, weight loss, and exercise are first-line therapeutic measures to reduce insulin resistance in patients with nonalcoholic fatty liver disease. […] There are no specific studies addressing the prevention of nonalcoholic fatty liver disease; however, because obesity and physical inactivity are strongly correlated with the condition, it is reasonable to expect that increasing physical activity and encouraging weight loss would be helpful. […] Patients with nonalcoholic fatty liver disease should be immunized for hepatitis A and B, and be encouraged to limit alcohol use to prevent the development of alcohol-induced liver disease.

• #57 4 Nonalcoholic Fatty Liver Disease Treatments

  https://www.aarp.org/health/conditions-treatments/reverse-nonalcoholic-fatty-liver-disease/

  Exercise plays a role in any weight loss plan of course but research suggests it plays a specific role in reversing NAFLD that has nothing to do with losing weight. […] A study published in Gastroenterology found that alcohol significantly impacts disease progression in other forms of liver disease, including NASH. […] We’re starting to move toward the recommendation that there is no safe amount of alcohol, says Rinella, a coauthor of the study.

• #58 Nonalcoholic fatty liver disease – Diagnosis and treatment – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/nonalcoholic-fatty-liver-disease/diagnosis-treatment/drc-20354573

  Choose a healthy diet. Eat a healthy diet that’s rich in fruits, vegetables and whole grains. Your health care team may suggest avoiding or limiting certain foods and drinks, such as white bread, red and processed meats, juices, and sweetened drinks. Keep track of all calories you take in. […] Exercise and be more active. Aim for at least 150 minutes of exercise a week. If you’re trying to lose weight, you might find that more exercise is helpful. But if you don’t already exercise regularly, get your health care team’s OK first and start slowly. […] Manage your diabetes. Follow your health care team’s advice to manage your diabetes. Take your medicines as told by your care team and watch your blood sugar closely. […] Lower your cholesterol and blood pressure. Improve your cholesterol levels and blood pressure if they are high. A healthy diet, exercise and medicines can help keep your cholesterol, triglycerides and blood pressure at healthy levels. […] Protect your liver. Avoid things that could harm your liver health. For example, don’t drink alcohol. Follow the instructions on all medicines and nonprescription drugs. Check with your health care team before using any herbal supplements, as some can harm the liver.

• #59 Nonalcoholic fatty liver disease – Diagnosis and treatment – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/nonalcoholic-fatty-liver-disease/diagnosis-treatment/drc-20354573

  Choose a healthy diet. Eat a healthy diet that’s rich in fruits, vegetables and whole grains. Your health care team may suggest avoiding or limiting certain foods and drinks, such as white bread, red and processed meats, juices, and sweetened drinks. Keep track of all calories you take in. […] Exercise and be more active. Aim for at least 150 minutes of exercise a week. If you’re trying to lose weight, you might find that more exercise is helpful. But if you don’t already exercise regularly, get your health care team’s OK first and start slowly. […] Manage your diabetes. Follow your health care team’s advice to manage your diabetes. Take your medicines as told by your care team and watch your blood sugar closely. […] Lower your cholesterol and blood pressure. Improve your cholesterol levels and blood pressure if they are high. A healthy diet, exercise and medicines can help keep your cholesterol, triglycerides and blood pressure at healthy levels. […] Protect your liver. Avoid things that could harm your liver health. For example, don’t drink alcohol. Follow the instructions on all medicines and nonprescription drugs. Check with your health care team before using any herbal supplements, as some can harm the liver.

• #60 Risk Prevention and Health Promotion for Non-Alcoholic Fatty Liver Diseases (NAFLD)

  https://www.mdpi.com/2673-4389/2/4/22

  Risk Prevention and Health Promotion for Non-Alcoholic Fatty Liver Diseases (NAFLD) […] The goal of this narrative review is to analyze risk prevention and health promotion strategies for NAFLD. […] Identifying and monitoring these populations is important to prevent the progression of future disease and comorbidities. […] Maintaining a healthy weight has been shown to benefit patient outcomes, and the current cornerstone of NAFLD therapy is weight loss and dietary interventions. […] Preventing T2D can decrease the incidence of NAFLD. […] Metabolic syndrome is a risk for the development and progression of NAFLD due to a chronic pro-inflammatory state and resulting state of insulin resistance. […] Implementing pharmacological therapy and lifestyle modifications simultaneously may provide additional preventative benefit to patients at increased risk of developing metabolic syndrome. […] NAFLD prevention or early detection are key points of focus, although routine screening for the general population or high-risk individuals is not advisable.

• #61 Nonalcoholic fatty liver disease – Diagnosis and treatment – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/nonalcoholic-fatty-liver-disease/diagnosis-treatment/drc-20354573

  Choose a healthy diet. Eat a healthy diet that’s rich in fruits, vegetables and whole grains. Your health care team may suggest avoiding or limiting certain foods and drinks, such as white bread, red and processed meats, juices, and sweetened drinks. Keep track of all calories you take in. […] Exercise and be more active. Aim for at least 150 minutes of exercise a week. If you’re trying to lose weight, you might find that more exercise is helpful. But if you don’t already exercise regularly, get your health care team’s OK first and start slowly. […] Manage your diabetes. Follow your health care team’s advice to manage your diabetes. Take your medicines as told by your care team and watch your blood sugar closely. […] Lower your cholesterol and blood pressure. Improve your cholesterol levels and blood pressure if they are high. A healthy diet, exercise and medicines can help keep your cholesterol, triglycerides and blood pressure at healthy levels. […] Protect your liver. Avoid things that could harm your liver health. For example, don’t drink alcohol. Follow the instructions on all medicines and nonprescription drugs. Check with your health care team before using any herbal supplements, as some can harm the liver.

• #62 Non-Alcoholic Fatty Liver Disease (NAFLD): Symptoms & Causes | NewYork-Presbyterian

  https://www.nyp.org/digestive/liver-diseases/fatty-liver-disease-non-alcoholic

  Preventing fatty liver disease is possible by following follow a healthy lifestyle that includes: […] Limiting or avoiding alcohol […] Maintaining a healthy weight […] Getting at least 30 minutes of exercise most days of the week […] Eating a nutrient-dense, healthy diet thats low in saturated fat, trans fat, and added sugars […] Managing blood sugar, triglyceride levels, and cholesterol levels […] Managing diabetes.

• #63 Risk Prevention and Health Promotion for Non-Alcoholic Fatty Liver Diseases (NAFLD)

  https://www.mdpi.com/2673-4389/2/4/22

  Risk Prevention and Health Promotion for Non-Alcoholic Fatty Liver Diseases (NAFLD) […] The goal of this narrative review is to analyze risk prevention and health promotion strategies for NAFLD. […] Identifying and monitoring these populations is important to prevent the progression of future disease and comorbidities. […] Maintaining a healthy weight has been shown to benefit patient outcomes, and the current cornerstone of NAFLD therapy is weight loss and dietary interventions. […] Preventing T2D can decrease the incidence of NAFLD. […] Metabolic syndrome is a risk for the development and progression of NAFLD due to a chronic pro-inflammatory state and resulting state of insulin resistance. […] Implementing pharmacological therapy and lifestyle modifications simultaneously may provide additional preventative benefit to patients at increased risk of developing metabolic syndrome. […] NAFLD prevention or early detection are key points of focus, although routine screening for the general population or high-risk individuals is not advisable.

• #64 Risk Prevention and Health Promotion for Non-Alcoholic Fatty Liver Diseases (NAFLD)

  https://www.mdpi.com/2673-4389/2/4/22

  Risk Prevention and Health Promotion for Non-Alcoholic Fatty Liver Diseases (NAFLD) […] The goal of this narrative review is to analyze risk prevention and health promotion strategies for NAFLD. […] Identifying and monitoring these populations is important to prevent the progression of future disease and comorbidities. […] Maintaining a healthy weight has been shown to benefit patient outcomes, and the current cornerstone of NAFLD therapy is weight loss and dietary interventions. […] Preventing T2D can decrease the incidence of NAFLD. […] Metabolic syndrome is a risk for the development and progression of NAFLD due to a chronic pro-inflammatory state and resulting state of insulin resistance. […] Implementing pharmacological therapy and lifestyle modifications simultaneously may provide additional preventative benefit to patients at increased risk of developing metabolic syndrome. […] NAFLD prevention or early detection are key points of focus, although routine screening for the general population or high-risk individuals is not advisable.

• #65 Non-alcohol fatty liver disease in Asia: Prevention and planning

  https://www.wjgnet.com/1948-5182/full/v7/i13/1788.htm

  Control and reduce the incidence of insulin resistance and MS is another important aspect of prevention and management of NAFLD. […] Not only Lifestyle changes, weight loss and regular physical activity are essential first steps for the prevention and treated patients with NAFLD, but also the prevention of metabolic risk factors, such as diabetes, dyslipidemia, hypertension is also very important.

• #66

  https://www.xiahepublishing.com/1555-3884/GE-2022-00005S

  A lack of physical activity is associated with an increased risk of NAFLD; the lower the level of habitual physical activity the greater the risk of intrahepatic fat content. […] Weight loss can have a significant impact on overweight or obese NAFLD patients. […] Proper sleep patterns and duration combined with other behavioral factors are important in NAFLD prevention. […] Bariatric surgery represents an alternative nonpharmacological management option for obese patients with NAFLD. […] Microbial metabolic manipulation via the microbiome and its metabolites could represent a potential option for NAFLD prevention, but more extensive research is required. […] Pharmacological therapies have had significant effects on NAFLD prevention, especially for patients in high-risk groups, such as those with concomitant T2DM. […] NAFLD prevention is important before the development of disease-related complications.

• #67

  https://xiahepublishing.com/1555-3884/GE-2022-00005S

  A lack of physical activity is associated with an increased risk of NAFLD; the lower the level of habitual physical activity the greater the risk of intrahepatic fat content. […] Weight loss can have a significant impact on overweight or obese NAFLD patients. […] Proper sleep patterns and duration combined with other behavioral factors are important in NAFLD prevention. […] Due to the superior efficacy of sustained weight loss and physical activity in NAFLD prevention, bariatric surgery represents an alternative nonpharmacological management option for obese patients with NAFLD. […] Microbial metabolic manipulation via the microbiome and its metabolites could represent a potential option for NAFLD prevention, but more extensive research is required. […] Many efforts are being made toward NAFLD prevention and management, mainly through controlling the modifiable predisposing risk factors, with many pharmacological agents still under investigation.

• #68 Fatty Liver Diet: What Foods to Eat and What Foods to Avoid

  https://www.healthline.com/health/fatty-liver-diet

  A diet rich in nuts is associated with reduced inflammation, insulin resistance, oxidative stress, and a lower prevalence of NAFLD. […] High doses of curcumin the active ingredient in turmeric might reduce markers of liver damage in people with NAFLD. […] Sunflower seeds are particularly high in vitamin E, an antioxidant often used (via supplementation) in treating NAFLD. […] Swapping out sources of saturated fat like butter, fatty cuts of meat, sausages, and cured meats for unsaturated fat sources like avocados, olive oil, nut butter, and fatty fish may be helpful for those with NAFLD. […] This may include dietary changes and lifestyle modifications like increasing physical activity, improving sleep, and reducing stress.

• #69 Nonalcoholic Fatty Liver Disease: Diagnosis and Management | AAFP

  https://www.aafp.org/pubs/afp/issues/2013/0701/p35.html

  A healthy diet, weight loss, and exercise are first-line therapeutic measures to reduce insulin resistance in patients with nonalcoholic fatty liver disease. […] There are no specific studies addressing the prevention of nonalcoholic fatty liver disease; however, because obesity and physical inactivity are strongly correlated with the condition, it is reasonable to expect that increasing physical activity and encouraging weight loss would be helpful. […] Patients with nonalcoholic fatty liver disease should be immunized for hepatitis A and B, and be encouraged to limit alcohol use to prevent the development of alcohol-induced liver disease.

• #70 Nonalcoholic Fatty Liver Disease (NAFLD)

  https://liverfoundation.org/liver-diseases/fatty-liver-disease/nonalcoholic-fatty-liver-disease-nafld/

  Nonalcoholic fatty liver disease (NAFLD), now called metabolic dysfunction-associated steatotic liver disease (MASLD), is the buildup of extra fat in liver cells that is not caused by alcohol. […] There are things people can do to lower their chances of developing NAFLD (now called MASLD). They include: Maintain a healthy weight. Eat meals that contain lean proteins, whole grains, fruits, vegetables, healthy oils, and low-fat dairy products. Try to include some kind of physical movement during most days of the week. If you are not currently physically active, speak with your doctor about the types of activities you can do that are safe for your current physical abilities. Limit or avoid alcohol intake. Only take medicines that you need and follow dosing recommendations. […] Early diagnosis of NAFLD, along with following medical advice, can reduce a persons chance NAFLD progressing to NASH and cirrhosis.

• #71 Fatty liver – nonalcoholic Information | Mount Sinai – New York

  https://www.mountsinai.org/health-library/diseases-conditions/fatty-liver-nonalcoholic

  Nonalcoholic fatty liver disease (NAFLD) is the buildup of fat in the liver that is not caused by drinking too much alcohol. […] The goal is to manage your risk factors and any health conditions. […] To help prevent NAFLD: Maintain a healthy weight. Eat a healthy diet. Exercise regularly. Limit alcohol consumption. Use medicines properly. […] Losing weight and making healthy lifestyle choices can help prevent more serious problems.

• #72

  https://www.xiahepublishing.com/1555-3884/GE-2022-00005S

  A lack of physical activity is associated with an increased risk of NAFLD; the lower the level of habitual physical activity the greater the risk of intrahepatic fat content. […] Weight loss can have a significant impact on overweight or obese NAFLD patients. […] Proper sleep patterns and duration combined with other behavioral factors are important in NAFLD prevention. […] Bariatric surgery represents an alternative nonpharmacological management option for obese patients with NAFLD. […] Microbial metabolic manipulation via the microbiome and its metabolites could represent a potential option for NAFLD prevention, but more extensive research is required. […] Pharmacological therapies have had significant effects on NAFLD prevention, especially for patients in high-risk groups, such as those with concomitant T2DM. […] NAFLD prevention is important before the development of disease-related complications.

• #73

  https://xiahepublishing.com/1555-3884/GE-2022-00005S

  A lack of physical activity is associated with an increased risk of NAFLD; the lower the level of habitual physical activity the greater the risk of intrahepatic fat content. […] Weight loss can have a significant impact on overweight or obese NAFLD patients. […] Proper sleep patterns and duration combined with other behavioral factors are important in NAFLD prevention. […] Due to the superior efficacy of sustained weight loss and physical activity in NAFLD prevention, bariatric surgery represents an alternative nonpharmacological management option for obese patients with NAFLD. […] Microbial metabolic manipulation via the microbiome and its metabolites could represent a potential option for NAFLD prevention, but more extensive research is required. […] Many efforts are being made toward NAFLD prevention and management, mainly through controlling the modifiable predisposing risk factors, with many pharmacological agents still under investigation.

• #74

  https://xiahepublishing.com/1555-3884/GE-2022-00005S

  A lack of physical activity is associated with an increased risk of NAFLD; the lower the level of habitual physical activity the greater the risk of intrahepatic fat content. […] Weight loss can have a significant impact on overweight or obese NAFLD patients. […] Proper sleep patterns and duration combined with other behavioral factors are important in NAFLD prevention. […] Due to the superior efficacy of sustained weight loss and physical activity in NAFLD prevention, bariatric surgery represents an alternative nonpharmacological management option for obese patients with NAFLD. […] Microbial metabolic manipulation via the microbiome and its metabolites could represent a potential option for NAFLD prevention, but more extensive research is required. […] Many efforts are being made toward NAFLD prevention and management, mainly through controlling the modifiable predisposing risk factors, with many pharmacological agents still under investigation.

• #75 Non-alcoholic fatty liver disease (NAFLD): a review of pathophysiology, clinical management and effects of weight loss | BMC Endocrine Disorders | Full Text

  https://bmcendocrdisord.biomedcentral.com/articles/10.1186/s12902-022-00980-1

  Bariatric and metabolic surgery has made enormous developments. Its benefits regarding weight loss and improvement of several metabolic diseases, like T2DM has been well established. […] Specifically looking at NAFLD related outcomes, bariatric and metabolic surgery has not been taken into account as treatment option in many meta-analyses to date, despite the increasing body of evidence and properly designed studies on this subject. […] A meta-analysis on 48 studies showed that the combination of pioglitazone and Roux-en Y Gastric Bypass surgery had the best effects on the NAFLD Activity Score.

• #76 Cardiovascular Risk in NAFLD | ECR Journal

  https://www.ecrjournal.com/articles/management-cardiovascular-risk-non-alcoholic-fatty-liver-disease-setting?language_content_entity=en

  A tailored multistep treatment approach has been proposed for the management of NAFLD as an effective tool to reduce the risk of CV disease in these patients. […] Lifestyle intervention is the key therapeutic intervention for patients with NAFLD. […] Dietary modification, increased physical activity, weight loss and alcohol avoidance are strongly recommended. […] Currently, weight loss is the most effective treatment for NAFLD, even in the minority of patients with NAFLD who do not have obesity, and is recommended in all guidelines. […] Even modest weight loss (5-10%) is associated with significant benefits. […] A systematic review and meta-analysis was performed to compare the impact of Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG) on NAFLD and NASH. […] The authors concluded that SG and RYGB were equivalently effective for treating NAFLD and NASH.

• #77

  https://www.ijbcp.com/index.php/ijbcp/article/view/4429

  Non-alcoholic fatty liver disease (NAFLD) is a common condition worldwide contributing to serious liver disorders like hepatic fibrosis and hepatocellular carcinoma. […] Presently there is no drug available for the treatment of NAFLD and only dietary measures, increased physical activity and exercise, antioxidants are the options. […] detailed pathophysiology, diagnostic methods and potential targets for prevention and timely treatment of NAFLD have been described.

• #78 (PDF) Potential targets for prevention and treatment of non-alcoholic fatty liver disease in adults

  https://www.academia.edu/112645142/Potential_targets_for_prevention_and_treatment_of_non_alcoholic_fatty_liver_disease_in_adults?uc-sb-sw=22976541

  Non-alcoholic fatty liver disease (NAFLD) is a common condition worldwide contributing to serious liver disorders like hepatic fibrosis and hepatocellular carcinoma. […] Presently there is no drug available for the treatment of NAFLD and only dietary measures, increased physical activity and exercise, antioxidants are the options. […] Due to the rising incidence, possible adverse consequences, and the futile available treatment options, prevention is the key to tackle this health menace. Spreading awareness, adopting a healthy lifestyle with appropriate dietary modifications, regular physical activity are the cornerstones. […] First-line management focuses on lifestyle modifications. Moderate weight reduction either by dietary restriction or by increased habitual physical activity is safe and highly recommended.

• #79 Cardiovascular Risk in NAFLD | ECR Journal

  https://www.ecrjournal.com/articles/management-cardiovascular-risk-non-alcoholic-fatty-liver-disease-setting?language_content_entity=en

  The majority of drugs are used to control CV risk factors and to help people to lose weight. […] Angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) have been noted as a promising medication given that the renin-angiotensin-aldosterone system (RAAS) is involved in the pathogenesis of both NAFLD and CV pathologies. […] Given that NAFLD has traditionally been interpreted as a liver disease with a high risk of liver-related complications, currently we know that NAFLD is a risk factor for atherosclerotic CVD, which is the principal cause of death in patients with NAFLD. […] The clinical implication is that patients with NAFLD are at an increased risk of CVD and should be considered as candidates not only for aggressive treatment of their liver disease but also for careful monitoring and potential treatment of underlying CVD risk factors, given that many patients with NAFLD will have major CVD events and die prior to the development of advanced liver disease. […] Further studies are needed to define optimal treatment strategies for the prevention of both hepatic and CV complications.

• #80 Non-alcoholic fatty liver disease-related hepatocellular carcinoma

  https://www.e-jlc.org/journal/view.php?number=514

  Amongst patients with diabetes, treatment with thiazolidinediones and metformin have also been associated with significant reductions in HCC risk. […] Statins may serve as another method of chemoprevention, with a meta-analysis of 24 studies (n=59,073 patients) demonstrating decreased HCC risk by 46%. […] Coffee has also shown promising results. A meta-analysis of 13 prospective cohort and case-control studies showed that increasing coffee consumption by one cup daily was associated with 15% HCC risk reduction.

• #81 Non-alcoholic fatty liver disease-related hepatocellular carcinoma

  https://www.e-jlc.org/journal/view.php?number=514

  Amongst patients with diabetes, treatment with thiazolidinediones and metformin have also been associated with significant reductions in HCC risk. […] Statins may serve as another method of chemoprevention, with a meta-analysis of 24 studies (n=59,073 patients) demonstrating decreased HCC risk by 46%. […] Coffee has also shown promising results. A meta-analysis of 13 prospective cohort and case-control studies showed that increasing coffee consumption by one cup daily was associated with 15% HCC risk reduction.

• #82 Non-alcoholic fatty liver disease (NAFLD): a review of pathophysiology, clinical management and effects of weight loss | BMC Endocrine Disorders | Full Text

  https://bmcendocrdisord.biomedcentral.com/articles/10.1186/s12902-022-00980-1

  Studies suggest that a Mediterranean diet, defined as reduced carbohydrate intake (especially sugars and refined carbohydrates) and increased monosaturated and omega-3 fatty acid intake, can reduce liver fat and thus positively contribute to the management of NAFLD. […] Weight loss is the primary therapy for most patients with NAFLD. Weight loss can improve liver biochemical tests, liver histology, serum insulin levels, and quality of life in patients with NAFLD. […] A significant body of literature has shown that weight loss induces a clinical improvement in patients with NAFLD or NASH. […] In the last few years there have been promising outcomes using pioglitazone (and related medication), but also the use of Glucagon-like peptide-1 (GLP-1) receptor agonists has shown significant improvement in hepatic outcomes in patients with NAFLD.

• #83 Non-alcoholic fatty liver disease: a practical approach to treatment | Frontline Gastroenterology

  https://fg.bmj.com/content/5/4/277

  The optimum diet to treat NAFLD is not known. Until further evidence is available, a calorie restricted diet (600Kcal less than a person needs to remain at the same weight) should be recommended aiming to lose 0.51kg per week until the target weight is achieved. […] Bariatric surgery has an increasing role in the management of patients with obesity and the metabolic syndrome. […] For patients with biopsy-proven NASH, where lifestyle intervention has failed, liver-directed pharmacotherapy with pioglitazone or vitamin E can be considered. […] Approximately 40%50% of patients with NAFLD attending secondary care clinics have T2DM and the majority have evidence of insulin resistance. […] Effective treatment of dyslipidaemias is vital in the management of NAFLD to reduce patients cardiovascular risk profile. […] Lifestyle interventions aimed at weight loss and increased activity are essential for all patients with NAFLD and if sustained are effective in the treatment of NAFLD.

• #84 Fatty Liver Diet: What Foods to Eat and What Foods to Avoid

  https://www.healthline.com/health/fatty-liver-diet

  Following a well-rounded, nutritious diet rich in fiber, lean or plant-based protein, and healthy fats is the best way to improve liver health, lower disease risk, and promote healthy weight loss. […] Fatty liver disease damages the liver and prevents it from working as well as it should, but lifestyle changes can prevent it from getting worse. […] The first line of treatment for overweight or obese individuals with NAFLD is gradual weight loss through a combination of calorie reduction, exercise, and healthy eating. […] A nutrient-dense, whole-food-based diet rich in fiber, protein, and unsaturated fats is generally recommended for people with NAFLD. […] Research suggests that supplementing with omega-3s may benefit those with NAFLD by reducing liver fat, boosting protective HDL cholesterol, and lowering triglyceride levels.

• #85 Non-Alcoholic Fatty Liver Disease (NAFLD) Pathogenesis and Natural Products for Prevention and Treatment

  https://www.mdpi.com/1422-0067/23/24/15489

  Non-alcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver disease, affecting approximately one-quarter of the global population, and has become a world public health issue. […] Therefore, it is of great practical importance to strengthen the research on the pathogenesis of NAFLD and to find safe and effective drugs for the prevention and treatment of NAFLD. […] With „NAFLD” and „Natural products” as key words, we searched PubMed database for relevant literature in the last ten years. It was found that the effects of natural products were usually evaluated in various signaling pathways related to lipid metabolism, oxidative stress, ER stress and lipotoxicity, and showed excellent therapeutic effects. […] This paper provides a review of the current state of research on the pathogenesis of NAFLD and summarizes the natural products in the recent literature that have modulating effects on in vitro and in vivo models of NAFLD. The development of NAFLD is mostly associated with lipid accumulation, oxidative stress, ER stress and lipotoxicity. […] These natural products may provide a new way for the research and discovery of new drugs for the treatment of NAFLD.

• #86 Fatty Liver Diet: What Foods to Eat and What Foods to Avoid

  https://www.healthline.com/health/fatty-liver-diet

  Following a well-rounded, nutritious diet rich in fiber, lean or plant-based protein, and healthy fats is the best way to improve liver health, lower disease risk, and promote healthy weight loss. […] Fatty liver disease damages the liver and prevents it from working as well as it should, but lifestyle changes can prevent it from getting worse. […] The first line of treatment for overweight or obese individuals with NAFLD is gradual weight loss through a combination of calorie reduction, exercise, and healthy eating. […] A nutrient-dense, whole-food-based diet rich in fiber, protein, and unsaturated fats is generally recommended for people with NAFLD. […] Research suggests that supplementing with omega-3s may benefit those with NAFLD by reducing liver fat, boosting protective HDL cholesterol, and lowering triglyceride levels.

• #87 Fatty Liver Diet: What Foods to Eat and What Foods to Avoid

  https://www.healthline.com/health/fatty-liver-diet

  A diet rich in nuts is associated with reduced inflammation, insulin resistance, oxidative stress, and a lower prevalence of NAFLD. […] High doses of curcumin the active ingredient in turmeric might reduce markers of liver damage in people with NAFLD. […] Sunflower seeds are particularly high in vitamin E, an antioxidant often used (via supplementation) in treating NAFLD. […] Swapping out sources of saturated fat like butter, fatty cuts of meat, sausages, and cured meats for unsaturated fat sources like avocados, olive oil, nut butter, and fatty fish may be helpful for those with NAFLD. […] This may include dietary changes and lifestyle modifications like increasing physical activity, improving sleep, and reducing stress.

• #88 Fatty Liver Diet: What Foods to Eat and What Foods to Avoid

  https://www.healthline.com/health/fatty-liver-diet

  A diet rich in nuts is associated with reduced inflammation, insulin resistance, oxidative stress, and a lower prevalence of NAFLD. […] High doses of curcumin the active ingredient in turmeric might reduce markers of liver damage in people with NAFLD. […] Sunflower seeds are particularly high in vitamin E, an antioxidant often used (via supplementation) in treating NAFLD. […] Swapping out sources of saturated fat like butter, fatty cuts of meat, sausages, and cured meats for unsaturated fat sources like avocados, olive oil, nut butter, and fatty fish may be helpful for those with NAFLD. […] This may include dietary changes and lifestyle modifications like increasing physical activity, improving sleep, and reducing stress.

• #89 Fatty Liver Diet: What Foods to Eat and What Foods to Avoid

  https://www.healthline.com/health/fatty-liver-diet

  A diet rich in nuts is associated with reduced inflammation, insulin resistance, oxidative stress, and a lower prevalence of NAFLD. […] High doses of curcumin the active ingredient in turmeric might reduce markers of liver damage in people with NAFLD. […] Sunflower seeds are particularly high in vitamin E, an antioxidant often used (via supplementation) in treating NAFLD. […] Swapping out sources of saturated fat like butter, fatty cuts of meat, sausages, and cured meats for unsaturated fat sources like avocados, olive oil, nut butter, and fatty fish may be helpful for those with NAFLD. […] This may include dietary changes and lifestyle modifications like increasing physical activity, improving sleep, and reducing stress.

• #90 Non-alcoholic fatty liver disease-related hepatocellular carcinoma

  https://www.e-jlc.org/journal/view.php?number=514

  Amongst patients with diabetes, treatment with thiazolidinediones and metformin have also been associated with significant reductions in HCC risk. […] Statins may serve as another method of chemoprevention, with a meta-analysis of 24 studies (n=59,073 patients) demonstrating decreased HCC risk by 46%. […] Coffee has also shown promising results. A meta-analysis of 13 prospective cohort and case-control studies showed that increasing coffee consumption by one cup daily was associated with 15% HCC risk reduction.

• #91 Dietary Polyphenols in the Prevention of Non-alcoholic Fatty Liver Disease | Frontiers Research Topic

  https://www.frontiersin.org/research-topics/31043/dietary-polyphenols-in-the-prevention-of-non-alcoholic-fatty-liver-diseaseundefined

  As one of the most prevalent causes of chronic liver disease, non-alcoholic fatty liver disease (NAFLD) refers to the clinical metabolic syndrome with excessive fat deposition in the liver due to high fat diet and ranges from simple steatosis to nonalcoholic steatohepatitis; the latter can develop to progressive fibrosis and hepatocellular carcinoma. NAFLD is a risk factor for many metabolic diseases, including type 2 diabetes, obesity, hyperuricemia, hypertension, and cardiovascular diseases. Therefore, effective therapies for treating NAFLD are urgently needed to prevent its further development into more severe metabolic diseases. […] Because Inflammation and oxidative stress are the main risk factors involved in the pathogenesis of NAFLD, recent studies suggest that consuming polyphenol-rich diets may have a role in the prevention and treatment of NAFLD.

• #92 Dietary Polyphenols in the Prevention of Non-alcoholic Fatty Liver Disease | Frontiers Research Topic

  https://www.frontiersin.org/research-topics/31043/dietary-polyphenols-in-the-prevention-of-non-alcoholic-fatty-liver-diseaseundefined

  This Research Topic aims to bring together the results of fundamental and applied research into bioactive compounds especially polyphenols, and also contribute to filling the gap in the knowledge about the protective effects and the underlying mechanisms of dietary polyphenols against non-alcoholic fatty liver disease (NAFLD). […] Innovative polyphenols (flavonoids, phenolic acid, alkaloids, tannins, etc.) which can show protective effects against non-alcoholic fatty liver disease (NAFLD); Analyze the composition of polyphenols in extracts or bioactive compounds that showed protective effects against NAFLD Explore the protective mechanisms from the aspects about glucose metabolism, lipid metabolism, inflammatory stress, apoptosis, gut microbiota, transcriptomics, proteomics, metabolomics, etc.

• #93 Nonalcoholic Fatty Liver Disease (NAFLD)

  https://liverfoundation.org/liver-diseases/fatty-liver-disease/nonalcoholic-fatty-liver-disease-nafld/

  Nonalcoholic fatty liver disease (NAFLD), now called metabolic dysfunction-associated steatotic liver disease (MASLD), is the buildup of extra fat in liver cells that is not caused by alcohol. […] There are things people can do to lower their chances of developing NAFLD (now called MASLD). They include: Maintain a healthy weight. Eat meals that contain lean proteins, whole grains, fruits, vegetables, healthy oils, and low-fat dairy products. Try to include some kind of physical movement during most days of the week. If you are not currently physically active, speak with your doctor about the types of activities you can do that are safe for your current physical abilities. Limit or avoid alcohol intake. Only take medicines that you need and follow dosing recommendations. […] Early diagnosis of NAFLD, along with following medical advice, can reduce a persons chance NAFLD progressing to NASH and cirrhosis.

• #94 Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)

  https://my.clevelandclinic.org/health/diseases/22437-non-alcoholic-fatty-liver-disease

  This condition often affects people who have obesity or Type 2 diabetes. You may not be able to prevent those conditions from happening. But its possible that early diagnosis and lifestyle changes may prevent MASLD. […] If you have obesity or Type 2 diabetes, your healthcare provider may recommend blood and imaging tests to screen for signs of this condition. Caught early on, lifestyle changes could reduce your risk.

• #95 Nonalcoholic Fatty Liver Disease (NAFLD)

  https://liverfoundation.org/liver-diseases/fatty-liver-disease/nonalcoholic-fatty-liver-disease-nafld/

  Nonalcoholic fatty liver disease (NAFLD), now called metabolic dysfunction-associated steatotic liver disease (MASLD), is the buildup of extra fat in liver cells that is not caused by alcohol. […] There are things people can do to lower their chances of developing NAFLD (now called MASLD). They include: Maintain a healthy weight. Eat meals that contain lean proteins, whole grains, fruits, vegetables, healthy oils, and low-fat dairy products. Try to include some kind of physical movement during most days of the week. If you are not currently physically active, speak with your doctor about the types of activities you can do that are safe for your current physical abilities. Limit or avoid alcohol intake. Only take medicines that you need and follow dosing recommendations. […] Early diagnosis of NAFLD, along with following medical advice, can reduce a persons chance NAFLD progressing to NASH and cirrhosis.

• #96 Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)

  https://my.clevelandclinic.org/health/diseases/22437-non-alcoholic-fatty-liver-disease

  This condition often affects people who have obesity or Type 2 diabetes. You may not be able to prevent those conditions from happening. But its possible that early diagnosis and lifestyle changes may prevent MASLD. […] If you have obesity or Type 2 diabetes, your healthcare provider may recommend blood and imaging tests to screen for signs of this condition. Caught early on, lifestyle changes could reduce your risk.

• #97 Managing Fatty Liver: Prevention and Treatment  | M3 Wake Research

  https://wakeresearch.com/about-us/news-updates/managing-fatty-liver-prevention-and-treatment/

  While fatty liver disease is a serious health issue, it can often be prevented and managed with lifestyle changes. […] Early diagnosis and intervention are important for managing fatty liver effectively and preventing its progression to more severe complications. Lifestyle changes, such as maintaining a healthy weight, engaging in regular physical activity, and eating a balanced diet, can help those with fatty liver improve their liver health and prevent further damage. […] By adopting healthy lifestyle habits, we can significantly reduce our risk and promote overall well-being: […] Develop healthy eating habits and regular physical activity to achieve and maintain a healthy body weight. Even smaller amounts of weight loss (5-10% of body weight) can improve liver health. […] Try getting at least 150 minutes of moderate-intensity exercise or 75 minutes of high-intensity exercise each week. Taking part in any form of physical activity is great, so look for activities you enjoy and incorporate them into your daily routine. […] By making a few changes now, avoiding the negative effects of our modern lifestyle and keeping your liver healthy is possible. Remember, taking charge of your health can have a big impact on your long-term well-being.

• #98 Is fatty liver disease reversible? Research and more

  https://www.medicalnewstoday.com/articles/is-fatty-liver-reversible

  While there is no treatment for fatty liver disease, certain lifestyle changes may help reverse the condition in its early stages. Avoiding alcohol and eating a balanced diet may help. […] According to a 2023 overview of research, NAFLD is a slowly progressive condition that is reversible at its early stage, which doctors call steatosis, or simple fatty liver. […] Additionally, the NHS notes that early detection and management may help reduce the amount of liver fat and stop NAFLD from progressing to end stage liver damage. […] A 2018 study indicates that lifestyle and diet modifications that lead to a 10% loss of total body weight may benefit over 90% of people with NASH by preventing the progression to liver fibrosis. […] According to a 2022 systematic review, lifestyle modifications are usually the first line of treatment for NAFLD.

• #99 Nonalcoholic fatty liver disease (NAFLD) prevention: role of Mediterranean diet and physical activity

  https://pmc.ncbi.nlm.nih.gov/articles/PMC6503241/

  Even if a large number of studies support the efficacy of both diet-based approaches and physical activity for NAFLD prevention, further future investigations are needed to confirm scientific data and to explore the possible molecular mechanisms underlying the association between NAFLD, diet and physical activity.

• #100 Nonalcoholic fatty liver disease (NAFLD) prevention: role of Mediterranean diet and physical activity – Trovato – Hepatobiliary Surgery and Nutrition

  https://hbsn.amegroups.org/article/view/23080/html

  Mediterranean diet interventions in non-Mediterranean countries may have additional challenges and need specific approaches. […] Together with diet, physical activity is suggested in NAFLD prevention and treatment, data from literature reported that physical activity influences hepatic metabolism and is inversely associated with the onset of NAFLD and NASH. […] Even if a large number of studies support the efficacy of both diet-based approaches and physical activity for NAFLD prevention, further future investigations are needed to confirm scientific data and to explore the possible molecular mechanisms underlying the association between NAFLD, diet and physical activity.

• #101 Nutrition could prevent or promote non-alcoholic fatty liver disease: an opportunity for intervention | The BMJ

  https://www.bmj.com/content/383/bmj-2023-075179

  The Mediterranean diet (rich in vegetables, fruit, beans, lentils nuts, whole grains, and fish) can reduce the risk of NAFLD and improve cardiometabolic health, as well as manage the effects of NAFLD in patients. […] Growing evidence suggests that the DASH (dietary approaches to stop hypertension) diet contributes to reduced NAFLD risk. […] A healthy lifestyle reduces the risk of developing NAFLD and could also promote NAFLD regression. […] Tackling NAFLD necessitates a multifaceted approach requiring collaboration across governments, healthcare institutions, communities, families, and individuals.

• #102 Advancing the global public health agenda for NAFLD: a consensus statement | Nature Reviews Gastroenterology & Hepatology

  https://www.nature.com/articles/s41575-021-00523-4

  The vast human and economic impact of NAFLD provides a compelling imperative for action. […] More and better data on NAFLD, especially in under-studied populations such as children, are needed to advance our understanding of the impact of the disease and to shape health system and public health responses accordingly. […] The liver health community can, in collaboration with other actors working with metabolic disease management, help lead this process in the coming years for the benefit of not only patients with liver disease but of all people living with NCDs. […] Policies, fiscal measures and legislation that address common risk factors for NCDs in a coordinated, synergistic way have the potential to create a lasting impact. […] The NAFLD prevention agenda should therefore include the creation of healthier, more equitable and sustainable societies as part of its vision.

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