Neuroma mortona
Epidemiologia

Neuroma Mortona, będąca drugą najczęstszą neuropatią kompresyjną po zespole cieśni nadgarstka, dotyka głównie osoby w wieku 30-60 lat, z przewagą kobiet (stosunek 4:1 do 9:1). Częstość występowania wynosi około 50,2 na 100 000 u mężczyzn i 87,5 na 100 000 u kobiet, a około 30% osób w średnim wieku bezobjawowo wykazuje radiologiczne cechy neuromy. Patogeneza opiera się na przewlekłym uwięźnięciu nerwu międzypalcowego, najczęściej w trzeciej przestrzeni międzypalcowej (72% przypadków), co prowadzi do metatarsalgii i charakterystycznego objawu Muldera. Diagnostyka opiera się na badaniu klinicznym oraz obrazowaniu USG i MRI, z czułością diagnostyczną obu metod na poziomie 95%, przy czym USG jest preferowaną, tańszą i równie skuteczną techniką. W diagnostyce różnicowej należy uwzględnić guzy reumatoidalne, zwłaszcza u pacjentów z reumatoidalnym zapaleniem stawów, które mogą imitować objawy neuromy Mortona.

Epidemiologia Neuromy Mortona

Neuroma Mortona (również znana jako neuroma międzypalcowa lub zapalenie nerwu międzypalcowego) to jedno z najczęstszych schorzeń stopy powodujących metatarsalgię. Stanowi ona drugą najczęstszą neuropatię kompresyjną po zespole cieśni nadgarstka1. Chociaż dokładna liczba zachorowań nie jest znana, niektóre badania szacują, że częstość występowania neuromy Mortona w populacji ogólnej wynosi około 30-33%2345.

Rozkład demograficzny

Neuroma Mortona dotyka najczęściej osoby w średnim wieku, ze szczególnym wskazaniem na kobiety67. Występowanie tej choroby u kobiet jest znacznie częstsze niż u mężczyzn, z szacunkowym stosunkiem kobiet do mężczyzn wynoszącym od 4:1 do nawet 9:1891011. Niektóre źródła podają nawet, że neuroma Mortona jest około 8-10 razy częstsza u kobiet niż u mężczyzn1213.

Najwyższa częstość występowania neuromy Mortona obserwowana jest u pacjentów w wieku 15-50 lat14, choć większość źródeł wskazuje na najczęstsze występowanie w wieku 30-60 lat1516. Średni wiek diagnozy to około 45-50 lat1718.

Standaryzowana częstotliwość występowania

Według dostępnych raportów, standaryzowana pod względem wieku częstość występowania neuromy Mortona wynosi 50,2 u mężczyzn i 87,5 u kobiet na 100 000 osób19. Badania wskazują, że około 30% osób w średnim wieku bez objawów ma radiologiczne cechy neuromy Mortona20.

Czynniki ryzyka i przyczyny

Zwiększona częstość występowania neuromy Mortona u kobiet jest często wiązana ze stylem obuwia, które wywiera dodatkowy nacisk i obciążenie na stopy21. Noszenie butów na wysokim obcasie z wąskimi czubkami jest jednym z głównych czynników ryzyka2223.

Do innych potencjalnych czynników ryzyka należą:

  • Nieprawidłowa budowa stopy (np. płaskostopie, wysokie łuki, paluchy koślawe, palce młotkowate)24
  • Nadwaga, która zwiększa nacisk na przodostopie2526
  • Sporty wysokoimpaktowe27
  • Nadmierna ruchomość stawów (hipermobilność)28
  • Historia napięcia nerwowego/nieprawidłowości, takich jak rwa kulszowa29
  • Schorzenia neurologiczne, takie jak stwardnienie rozsiane i cukrzyca30

Neuroma Mortona jest uważana za zespół uwięźnięcia nerwu31. Stan ten jest spowodowany przewlekłym uwięźnięciem nerwu przez więzadło międzyśródstopne32. Choroba rozwija się głównie w wyniku niewłaściwego lub uciskającego obuwia lub, rzadziej, trakcji nerwowej wynikającej z nieprawidłowej struktury stopy (np. deformacji stopy szpakowatej)33.

Lokalizacja i występowanie

Najczęstsze miejsca występowania

Neuroma Mortona najczęściej występuje w trzeciej przestrzeni międzypalcowej (między trzecim a czwartym palcem), stanowiąc około 72% przypadków3435. Druga przestrzeń międzypalcowa jest dotknięta w około 30% przypadków, a czwarta przestrzeń międzypalcowa jest rzadko dotknięta, tylko w około 5% przypadków3637. Według innego źródła, nerw międzypalcowy trzeci i przestrzeń trzecia są zajęte u 87% dotkniętych osób38.

Neuroma Mortona rzadko dotyka obu stóp jednocześnie39, choć niektóre źródła wskazują, że w 15-21% przypadków może być obustronna40. Znalezienie dwóch neuromatów na tej samej stopie jest powszechne41.

Neuromy bezobjawowe

Częstość występowania bezobjawowych neurom Mortona w populacji ogólnej wynosi około 30%42. Badania wykazały, że poprzeczna średnica bezobjawowych neurom jest generalnie mniejsza niż u pacjentów z bólem (około 3-7 mm lub średnio 4,5 mm w porównaniu do objawowych neurom, które zwykle mieszczą się w zakresie 4-8 mm lub średnio 5,6 mm)43. Statystycznie rzecz biorąc, większe neuromy Mortona są bardziej narażone na bolesność44.

Zmiany o średnicy poprzecznej mniejszej niż 5 mm są często bezobjawowe i występują u 30% osób, podczas gdy zmiany o średnicy poprzecznej 5 mm lub większej są związane z objawami45.

Diagnostyka i nadzór

Metody diagnostyczne

Neuroma Mortona jest zwykle diagnozowana przez lekarza na podstawie wywiadu i badania stopy46. Czasami lekarz może wyczuć „neuromę” lub obszar zgrubienia w stopie, który może być bolesny. Ucisk na obszar między długimi kośćmi stopy może ujawnić bolesne miejsce47.

Objawy neuromy międzypalcowej są często specyficzne, a diagnoza jest potwierdzana przez bolesność przy podeszwowym badaniu palpacyjnym przestrzeni międzypalcowej oraz przez odtworzenie promieniującego, palącego bólu, często towarzyszącego zauważalnemu kliknięciu, poprzez ściskanie przestrzeni (objaw Muldera)48.

Obrazowanie diagnostyczne

W celu potwierdzenia diagnozy i wykluczenia innych przyczyn bólu przodostopia zaleca się badania obrazowe, takie jak ultrasonografia (USG) i obrazowanie metodą rezonansu magnetycznego (MRI)49.

USG jest promowane jako skuteczna metoda wykrywania neuromy Mortona, równie skuteczna jak MRI. W badaniu przeprowadzonym przez Bianca B i wsp. w 2015 roku, czułość diagnostyczna zarówno MRI, jak i USG została obliczona na 95%50. Inne badania wykazały, że USG jest dokładniejsze niż MRI w diagnostyce neuromy Mortona51.

Najnowszy dokument konsensusowy Europejskiego Towarzystwa Radiologicznego (2017) ustanowił USG jako technikę z wyboru do diagnostyki neuromy Mortona52. MRI i ultrasonografia mogą być wykorzystywane do diagnostyki neuromy Mortona. Obie metody obrazowania są dokładne w diagnostyce, ale USG jest znacznie tańsze53.

Należy jednak zaznaczyć, że dowody sonograficzne neuromy Mortona są niewiarygodne, chyba że korelują z badaniem klinicznym i zgłaszanymi objawami. Badanie kliniczne powinno być złotym standardem diagnostyki neuromy Mortona54.

Współwystępujące schorzenia i reumatyzm

Interesującym aspektem epidemiologii neuromy Mortona jest jej związek z chorobą reumatoidalną. W jednym badaniu, wśród 101 stóp, które prezentowały objawy i oznaki podobne do neuromy Mortona, guzki reumatoidalne międzyśródstopne znaleziono w pięciu stopach (trzech pacjentów)55.

Zapalenie błony maziowej i guzki reumatoidalne wywołujące objawy naśladujące neuromę Mortona były opisywane w literaturze, ale większość przypadków znaleziono u wcześniej zdiagnozowanych pacjentów z reumatoidalnym zapaleniem stawów56. Częstość występowania nerwiaka międzypalcowego u pacjentów z reumatoidalnym zapaleniem stawów została określona na 1 na 520, z przewagą u kobiet57.

Według jednego z badań, 40% pacjentów z jednej kliniki, u których zdiagnozowano neuromę międzypalcową Mortona, miało zdiagnozowane reumatoidalne zapalenie stawów w tym czasie lub później rozwinęło tę chorobę58.

Awerbuch i wsp. zasugerowali poszukiwanie histologicznych dowodów choroby reumatoidalnej we wszystkich tkankach wyciętych w chirurgicznym leczeniu neuromy Mortona, ponieważ wierzyli, że choroba reumatoidalna jest podstawową etiologią u znacznej liczby pacjentów59.

Sugeruje się zatem, że guzek pochodzenia reumatoidalnego powinien być brany pod uwagę w diagnostyce różnicowej neuromy Mortona, nie tylko u pacjentów z znaną historią reumatoidalnego zapalenia stawów, ale także u pacjentów, którzy prezentują objawy neuromy Mortona i mają nietypowe odkrycia śródoperacyjne60.

Skuteczność leczenia i prognozy

Neuroma Mortona najlepiej zarządzana jest niechirurgicznie przez interdyscyplinarny zespół pracowników służby zdrowia, w tym podologa, chirurga ortopedę, lekarza sportowego, pielęgniarkę praktykującą i lekarza podstawowej opieki zdrowotnej61.

Leczenie zachowawcze

Około jednej trzeciej osób z neuromą Mortona poprawia się tylko przy zmianie obuwia i używaniu wkładek śródstopnych62. Leczenie zachowawcze przynosi ulgę 80 procent pacjentów z neuromą Mortona63.

Kilka badań wykazało, że kombinacja zmian w obuwiu, doustnych leków przeciwzapalnych, ortez i/lub iniekcji kortykosteroidów zapewni ulgę u ponad 80% osób z neuromą Mortona64.

W największej metaanalizie do tej pory, jedynymi zabiegami zachowawczymi o wystarczających dowodach, aby je zalecać, są: manipulacja / fizjoterapia i iniekcja steroidów65. Nie ma konsensusu co do tego, czy iniekcje powinny być przeprowadzane na ślepo, czy pod kontrolą USG66.

Leczenie chirurgiczne

Dla mniejszości osób, które mają uporczywe, uniemożliwiające funkcjonowanie objawy, chirurgia może być opcją67. Leczenie chirurgiczne z neurektomią (usunięcie części nerwu) lub dekompresją nerwu ma najwyższy wskaźnik sukcesu, przy czym większość badań donosi o 80-95% skuteczności6869.

Według badań, ogólna satysfakcja została oceniona jako doskonała lub dobra przez 56 (85%) z 66 pacjentów, a 46 (65%) z siedemdziesięciu jednej stóp było wolnych od bólu w czasie ostatecznej kontroli70.

Jeśli objawy nawracają, zaleca się operację rewizyjną przez dostęp podeszwowy, aby umożliwić identyfikację i resekcję gałęzi podeszwowej nerwu (częstsza przyczyna nawrotu objawów)71.

Dane porównujące wyniki różnych metod leczenia są ograniczone72. Nasze badanie wykazało, że nie ma wystarczających spójnych, znormalizowanych informacji, aby zapewnić porównanie dwóch podejść (chirurgicznego i zachowawczego)73.

Powikłania i zapobieganie

Jeśli neuroma Mortona nie jest leczona, może spowodować uszkodzenie nerwu lub przewlekły ból w dotkniętej stopie74. Należy odwiedzić pracownika służby zdrowia, gdy tylko zauważy się jakiekolwiek objawy neuromy Mortona. Im wcześniej pracownik służby zdrowia zdiagnozuje i leczy neuromę Mortona, tym mniejsze jest prawdopodobieństwo wystąpienia powikłań75.

Neuromy Mortona nie znikną same z siebie, chociaż leczenie i modyfikacje stylu życia łagodzą objawy u większości osób. Stan ten ma tendencję do pojawiania się i zanikania76.

Nie zawsze można zapobiec neuromie Mortona, ale niektóre proste środki ostrożności pomogą uniknąć problemów77. Zapewnienie, że buty są dobrze dopasowane, na niskim obcasie i z szerokim obszarem na palce, może pomóc w zapobieganiu neuromie Mortona78.

Amerykańskie Kolegium Chirurgów Stopy i Kostki (ACFAS) ostrzega kobiety biegaczki, że kombinacja noszenia wąskich, spiczastych butów w pracy i uderzenia, jakiego doświadczają ich stopy podczas biegania, może zwiększyć ryzyko rozwoju neuromy Mortona79.

Najlepszym czasem na wizytę u chirurga stopy i kostki jest wczesny etap rozwoju objawów. Wczesna diagnoza neuromy Mortona znacznie zmniejsza potrzebę bardziej inwazyjnych zabiegów i może pomóc uniknąć operacji80.

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  1. 11.04.2026
  2. www.leksykon.com.pl

Materiały źródłowe

  • #1 Morton neuroma – Knowledge @ AMBOSS
    https://www.amboss.com/us/knowledge/morton-neuroma/
    Morton neuroma is the second most common compressive neuropathy after carpal tunnel syndrome. […] The third interdigital space and nerve are involved in 87% of affected individuals. […] Epidemiological data refers to the US, unless otherwise specified.
  • #2 Study of the Anatomical Association between Morton’s Neuroma and the Space Inferior to the Deep Transverse Metatarsal Ligament Using Ultrasound
    https://www.mdpi.com/2075-4418/12/6/1367
    Morton’s neuroma (MN) is a frequent condition in the general population with a prevalence of 30–33% and a female to male incidence of 4:1. […] This study has been designed as a cross-sectional descriptive epidemiological study, which was carried out between February 2020 and October 2020 in 100 patients (200 measurements) from Maria del Mar clinic (Alcazar de San Juan, Ciudad Real, Spain). […] The multivariate analysis using logistic regression, where the dependent variable is the type of patient (control and patient with MN), showed that the variables that were statistically significant (p < 0.05) were b (right and left) of the metatarsals and patient’s weight. [...] At the diagnostic level, the latest consensus document of the European Society of Radiology (2017) established US as the technique of choice for the diagnosis of MN, which points out the value of our results.
  • #3 Morton neuroma | Radiology Reference Article | Radiopaedia.org
    https://radiopaedia.org/articles/morton-neuroma-1?embed_domain=hackmd.io%2525252F%25252540yipuafecsl2jsu8smr5njq%2525252Fbnjhjgjghjghjghradiopaedia-icon-144.pngfavicon.ico&lang=gb
    Morton neuromas most often occur in middle-aged individuals and are many times more common in women than men. Approximately 30% of asymptomatic middle-aged persons have radiologic findings of a Morton neuroma. […] The condition is thought to be due to chronic entrapment of the nerve by the intermetatarsal ligament.
  • #4 Fact No. #6: Asymptomatic Morton’s Neuroma
    https://www.mortonsneuroma.com/blog/mortons-neuroma-facts-6-asymtompatic-mortons-neuroma/
    A study reported in the peer reviewed journal Radiology (1), explored the factors that may define the severity of symptoms of Mortons neuroma. The prevalence of asymptomatic Morton neuromas in general population is roughly 30%. […] The transverse diameter of asymptomatic neuromas is generally smaller than in patients with pain. (Approximately 3mm-7mm or an average 4.5mm as opposed to symptomatic neuromas that are usually in the range of 4mm-8 mm or an average of 5.6 mm). So statistically speaking, the larger Mortons neuromas are more likely to be painful.
  • #5 Morton’s Neuroma: Causes, Symptoms & Treatment
    https://my.clevelandclinic.org/health/diseases/15118-mortons-neuroma
    Mortons neuromas are common. Experts estimate that around 1 in 3 people has a Mortons neuroma at some point in their life. […] If a Mortons neuroma isnt treated, it can cause nerve damage or chronic pain in your affected foot. Visit a healthcare provider as soon as you notice any Mortons neuroma symptoms. The sooner a provider diagnoses and treats a Mortons neuroma, the less likely it is youll experience complications.
  • #6 Morton Neuroma – StatPearls – NCBI Bookshelf
    https://www.ncbi.nlm.nih.gov/sites/books/NBK470249/
    Morton neuroma is common in middle-aged women, and the incidence is at least five times more common in females when compared to men. The exact incidence is unknown. Rarely are both feet affected. Finding two neuromas on the same foot is common. […] Morton neuroma is best managed non-surgically with an interprofessional team of healthcare professionals, including a podiatrist, orthopedic surgeon, sports physician, nurse practitioner, and primary care provider. The patient may require pain medications, but the key is changes in shoe wear. The nurse should encourage the patient to wear appropriate, well-padded, non-constrictive shoewear. Obese patients may benefit from weight loss, so a dietary consult is appropriate. The patient may benefit from physical therapy and the use of warm compresses and ice to ease the pain.
  • #7
    https://www.orthobullets.com/foot-and-ankle/7041/interdigital-mortons-neuroma
    Interdigital Neuromas, also known as Morton’s neuroma, is a compressive neuropathy of the interdigital nerve that often leads to plantar forefoot pain. […] Epidemiology demographics middle-aged females (9:1) […] body location most commonly involves the 3rd and 4th interdigital nerves between the metatarsal heads (3rd webspace).
  • #8 Study of the Anatomical Association between Morton’s Neuroma and the Space Inferior to the Deep Transverse Metatarsal Ligament Using Ultrasound
    https://www.mdpi.com/2075-4418/12/6/1367
    Morton’s neuroma (MN) is a frequent condition in the general population with a prevalence of 30–33% and a female to male incidence of 4:1. […] This study has been designed as a cross-sectional descriptive epidemiological study, which was carried out between February 2020 and October 2020 in 100 patients (200 measurements) from Maria del Mar clinic (Alcazar de San Juan, Ciudad Real, Spain). […] The multivariate analysis using logistic regression, where the dependent variable is the type of patient (control and patient with MN), showed that the variables that were statistically significant (p < 0.05) were b (right and left) of the metatarsals and patient’s weight. [...] At the diagnostic level, the latest consensus document of the European Society of Radiology (2017) established US as the technique of choice for the diagnosis of MN, which points out the value of our results.
  • #9 Physical Medicine and Rehabilitation for Morton Neuroma: Practice Essentials, Pathophysiology, Epidemiology
    https://emedicine.medscape.com/article/308284-overview
    Morton’s neuroma is a common disease entity of the foot. […] The incidence of Morton’s neuroma is presumed to be the same internationally as in United States. […] The female-to-male ratio for Morton’s neuroma is 5:1. […] The highest prevalence of Morton’s neuroma is found in patients aged 15-50 years, but the condition may occur in any ambulatory patient.
  • #10 Morton’s Neuroma – OrthoInfo – AAOS
    https://orthoinfo.aaos.org/en/diseases–conditions/mortons-neuroma
    Morton’s neuromas are around 8 times more common in women than men and typically affect people between the ages of 30 and 60, though they can occur outside of this age range as well. […] Studies have shown that many people can achieve lasting relief with a combination of shoe wear modifications, orthoses, anti-inflammatory medications (e.g., ibuprofen or naproxen), and/or corticosteroid injections. […] Surgical intervention with neurectomy (removal of part of the nerve) or decompression of the nerve has the highest success rate, with most studies reporting an 80 to 95% success rate.
  • #11 Morton Neuroma (Interdigital Neuroma) | 5-Minute Clinical Consult
    https://im.unboundmedicine.com/medicine/view/5-Minute-Clinical-Consult/1688491/all/Morton_Neuroma__Interdigital_Neuroma_?q=Gout
    Prevalence: Unknown. Mean age: 45 to 50 years. Predominant sex: female male (8:1). […] Prevalence: Unknown. Mean age: 45 to 50 years. Predominant sex: female male (8:1).
  • #12 Pain In The Ball of Your Foot? It Could Be Morton’s Neuroma – Wilmington Health
    https://www.wilmingtonhealth.com/news/pain-in-the-ball-of-your-foot-it-could-be-mortons-neuroma/
    Mortons neuroma isnt as well-known as bunions and plantar fasciitis, but its quite common. About 30% of the general population has Mortons neuroma, says Sharrona Williams, MD, a practicing orthopedic surgeon at Wilmington Health, specializing in foot and ankle care. They are approximately eight times more common in women than men. […] If you have Mortons neuroma symptoms, acting quickly is essential, since the thickening of the nerve tissue often worsens over time. Theres no way to cure a neuroma, but ongoing treatment can significantly reduce or even eliminate pain. Even better? The outlook is quite positive. Most folks can treat their Mortons neuroma conservatively, Dr. Williams says. Approximately 80-85% dont require surgery.
  • #13 Foot conditions: Recognizing and treating Morton’s neuroma – Harvard Health
    https://www.health.harvard.edu/newsletter_article/Foot_conditions_Recognizing_and_treating_Mortons_neuroma
    Morton’s neuroma is about 10 times more common in women than in men; women in their 30s and 40s who wear high-fashion shoes are particularly vulnerable. […] The cause is a thickening of the nerve tissue between the bones at the base of the toes. […] Symptoms include pain and burning in the ball of the foot and often numbness in the toes.
  • #14 Physical Medicine and Rehabilitation for Morton Neuroma: Practice Essentials, Pathophysiology, Epidemiology
    https://emedicine.medscape.com/article/308284-overview
    Morton’s neuroma is a common disease entity of the foot. […] The incidence of Morton’s neuroma is presumed to be the same internationally as in United States. […] The female-to-male ratio for Morton’s neuroma is 5:1. […] The highest prevalence of Morton’s neuroma is found in patients aged 15-50 years, but the condition may occur in any ambulatory patient.
  • #15 Morton’s Neuroma – OrthoInfo – AAOS
    https://orthoinfo.aaos.org/en/diseases–conditions/mortons-neuroma
    Morton’s neuromas are around 8 times more common in women than men and typically affect people between the ages of 30 and 60, though they can occur outside of this age range as well. […] Studies have shown that many people can achieve lasting relief with a combination of shoe wear modifications, orthoses, anti-inflammatory medications (e.g., ibuprofen or naproxen), and/or corticosteroid injections. […] Surgical intervention with neurectomy (removal of part of the nerve) or decompression of the nerve has the highest success rate, with most studies reporting an 80 to 95% success rate.
  • #16 Morton’s Neuroma: Causes, Symptoms, and Treatment
    https://patient.info/foot-care/heel-and-foot-pain-plantar-fasciitis/mortons-neuroma
    About three people out of four who have Morton’s neuroma are women. It most commonly affects people between the ages of 40 and 60 but can occur at any age. […] Poorly fitting or constricting shoes can contribute to Morton’s neuroma. It is more common in women who habitually wear high-heeled shoes or in men who are required to wear tight (constrictive) footwear. It may also be more common in ballet dancers and runners. In some people there is no obvious cause. […] Morton’s neuroma is usually diagnosed by a clinician listening to the symptoms and examining the foot. Sometimes a doctor can feel the 'neuroma’, or an area of thickening in your foot, which may be tender. Pressing on the area between the long bones in your foot may show a tender spot. […] About one third of people with Morton’s neuroma get better just with changing their footwear and using metatarsal pads. Of those who choose to have surgery, about three out of four will have good results with relief of their symptoms. […] Ensuring that shoes are well fitted, low-heeled and with a wide toe area may help to prevent Morton’s neuroma.
  • #17 Morton Neuroma (Interdigital Neuroma) | 5-Minute Clinical Consult
    https://im.unboundmedicine.com/medicine/view/5-Minute-Clinical-Consult/1688491/all/Morton_Neuroma__Interdigital_Neuroma_?q=Gout
    Prevalence: Unknown. Mean age: 45 to 50 years. Predominant sex: female male (8:1). […] Prevalence: Unknown. Mean age: 45 to 50 years. Predominant sex: female male (8:1).
  • #18 Mortons Neuroma – OrthoPaedia
    https://www.orthopaedia.com/mortons-neuroma/
    The incidence of Morton’s neuroma is not known. What is known is the incidence is about 5 times higher in women than in men. The left and right feet are equally affected. The typical patient is about 45 years old. […] Most chronic pain in the forefoot is NOT the result of a Morton’s neuroma. Other more common sources of metatarsalgia (the medical term for forefoot pain) are peripheral neuropathy (from diabetes most likely); stress fractures of the metatarsals; synovitis of the MTP joints, or other inflammation; and trauma. Also, to be considered are Freiberg’s infraction (avascular necrosis of the metatarsal head), tarsal tunnel syndrome, infection, and tumors. A thorough physical examination is essential in differentiating among these possible diagnoses.
  • #19 Effect of surgical approach on the treatment of Morton’s neuroma: a systematic review and meta-analysis | Journal of Foot and Ankle Research | Full Text
    https://jfootankleres.biomedcentral.com/articles/10.1186/s13047-023-00660-w
    According to reports, the age standardized incidence rate of Mortons neuroma is 50.2 in males and 87.5 in females per 100,000 individuals. […] The purpose of this systematic review and meta-analysis was to compare the surgical resection of Mortons neuroma via dorsal and plantar approaches. […] Our study found that there is insufficient consistent, standardized information to provide a comparison of the two approaches. […] It provides researchers a hypothesis that the frequency of adverse events in the treatment of Mortons neuroma by dorsal and plantar approaches may be the similar, but the types are different, based on the current small, low-level evidence.
  • #20 Morton neuroma | Radiology Reference Article | Radiopaedia.org
    https://radiopaedia.org/articles/morton-neuroma-1?embed_domain=hackmd.io%2525252F%25252540yipuafecsl2jsu8smr5njq%2525252Fbnjhjgjghjghjghradiopaedia-icon-144.pngfavicon.ico&lang=gb
    Morton neuromas most often occur in middle-aged individuals and are many times more common in women than men. Approximately 30% of asymptomatic middle-aged persons have radiologic findings of a Morton neuroma. […] The condition is thought to be due to chronic entrapment of the nerve by the intermetatarsal ligament.
  • #21 Azthena logo with the word Azthena
    https://www.news-medical.net/health/What-is-Mortons-Neuroma.aspx
    Morton’s neuroma can affect anyone of any gender and age; however, it is most common among middle-aged women, with a female to male ratio of 5:1. […] This increased prevalence in women has been linked to the style of footwear often worn by these women that put additional pressure and stress on the feet. […] It is also more common among people that participate in high-impact sports.
  • #22 Morton’s Neuroma: Causes, Treatment, and More
    https://www.healthline.com/health/mortons-neuroma
    Mortons neuroma is a benign but painful condition that affects the ball of the foot. […] It most commonly occurs in middle-aged people, especially middle-aged women. […] Mortons neuroma is often associated with: flat feet, high arches, bunions, hammer toes. […] Mortons neuroma is treatable, but if its not treated promptly it can lead to permanent nerve damage. […] Conservative treatment brings people with Mortons neuroma relief 80 percent of the time. […] There are few long-term studies of surgical treatment results, but the Cleveland Clinic reports that surgery effectively relieves or reduces symptoms in 75 to 85 percent of cases. […] Statistics comparing the results of different treatments are limited.
  • #23 Morton’s Neuroma – Harvard Health
    https://www.health.harvard.edu/a_to_z/mortons-neuroma-a-to-z
    A Morton’s neuroma is a benign (noncancerous) swelling along a nerve in the foot that carries sensations from the toes. […] The condition is much more common in women than men, probably as a result of wearing high-heeled, narrow-toed shoes. […] Being overweight also increases the risk of a Morton’s neuroma. […] More than 80% of people with a Morton’s neuroma will respond to conservative treatment. For the minority of people who have persistent, disabling symptoms, surgery may be an option.
  • #24 Morton’s Neuroma: Causes, Treatment, and More
    https://www.healthline.com/health/mortons-neuroma
    Mortons neuroma is a benign but painful condition that affects the ball of the foot. […] It most commonly occurs in middle-aged people, especially middle-aged women. […] Mortons neuroma is often associated with: flat feet, high arches, bunions, hammer toes. […] Mortons neuroma is treatable, but if its not treated promptly it can lead to permanent nerve damage. […] Conservative treatment brings people with Mortons neuroma relief 80 percent of the time. […] There are few long-term studies of surgical treatment results, but the Cleveland Clinic reports that surgery effectively relieves or reduces symptoms in 75 to 85 percent of cases. […] Statistics comparing the results of different treatments are limited.
  • #25 Morton’s Neuroma – Harvard Health
    https://www.health.harvard.edu/a_to_z/mortons-neuroma-a-to-z
    A Morton’s neuroma is a benign (noncancerous) swelling along a nerve in the foot that carries sensations from the toes. […] The condition is much more common in women than men, probably as a result of wearing high-heeled, narrow-toed shoes. […] Being overweight also increases the risk of a Morton’s neuroma. […] More than 80% of people with a Morton’s neuroma will respond to conservative treatment. For the minority of people who have persistent, disabling symptoms, surgery may be an option.
  • #26 Plantar Digital Neuroma (Morton’s Neuroma) | NHS Lanarkshire
    https://www.nhslanarkshire.scot.nhs.uk/services/podiatry/plantar-digital-neuroma/
    Mortons neuroma can be a painful condition that affects the nerves that runs between your toes in the ball of the foot. People between the ages of 35 and 60 are more prone to developing this condition but it can happen at any age, affecting women more than men. […] The exact cause of Mortons neuroma is not known. It is thought to develop due to increased stress and irritation on one of the plantar digital nerves. This increased stress may cause the nerve to be compressed, rubbed, or stretched. Ill-fitting footwear is a well-known cause in aggravating your symptoms. […] People who tend to have increased weight can have more prolonged pain and poorer tissue healing due to increased levels of inflammation in the body. Reducing your weight can generally help improve and pain and the healing process.
  • #27 Azthena logo with the word Azthena
    https://www.news-medical.net/health/What-is-Mortons-Neuroma.aspx
    Morton’s neuroma can affect anyone of any gender and age; however, it is most common among middle-aged women, with a female to male ratio of 5:1. […] This increased prevalence in women has been linked to the style of footwear often worn by these women that put additional pressure and stress on the feet. […] It is also more common among people that participate in high-impact sports.
  • #28
    https://mortonsneuroma.surgery/mortons-neuroma/mortons-neuroma/about-mortons-neuroma/
    Morton’s neuroma is a painful foot condition caused by a thickened nerve between the third and fourth toes. This can also occur between other toes, which is known as an interdigital neuroma. […] The causes of Morton’s neuroma can be divided into biomechanical, anatomical, footwear and activity/sport related categories. As the condition is often caused by footwear such as high-heeled shoes, it is not surprising that it is more common in women than men. […] The condition is also common among people who are hypermobile (double jointed), and those with a history of nerve tension/abnormality such as sciatica. Neurological conditions like MS and diabetes are also linked to Mortons neuroma due to the underlying disease process. […] We always investigate the source and possible underlying causes for a neuroma. This may involve an in-depth assessment in our gait analysis facility or a specialist referral (to a neurologist, for example).
  • #29
    https://mortonsneuroma.surgery/mortons-neuroma/mortons-neuroma/about-mortons-neuroma/
    Morton’s neuroma is a painful foot condition caused by a thickened nerve between the third and fourth toes. This can also occur between other toes, which is known as an interdigital neuroma. […] The causes of Morton’s neuroma can be divided into biomechanical, anatomical, footwear and activity/sport related categories. As the condition is often caused by footwear such as high-heeled shoes, it is not surprising that it is more common in women than men. […] The condition is also common among people who are hypermobile (double jointed), and those with a history of nerve tension/abnormality such as sciatica. Neurological conditions like MS and diabetes are also linked to Mortons neuroma due to the underlying disease process. […] We always investigate the source and possible underlying causes for a neuroma. This may involve an in-depth assessment in our gait analysis facility or a specialist referral (to a neurologist, for example).
  • #30
    https://mortonsneuroma.surgery/mortons-neuroma/mortons-neuroma/about-mortons-neuroma/
    Morton’s neuroma is a painful foot condition caused by a thickened nerve between the third and fourth toes. This can also occur between other toes, which is known as an interdigital neuroma. […] The causes of Morton’s neuroma can be divided into biomechanical, anatomical, footwear and activity/sport related categories. As the condition is often caused by footwear such as high-heeled shoes, it is not surprising that it is more common in women than men. […] The condition is also common among people who are hypermobile (double jointed), and those with a history of nerve tension/abnormality such as sciatica. Neurological conditions like MS and diabetes are also linked to Mortons neuroma due to the underlying disease process. […] We always investigate the source and possible underlying causes for a neuroma. This may involve an in-depth assessment in our gait analysis facility or a specialist referral (to a neurologist, for example).
  • #31 Is Morton’s Neuroma a Nerve Entrapment Syndrome?
    https://www.mortonsneuroma.com/blog/is-mortons-neuroma-nerve-entrapment-syndrome/
    Mortons neuroma is really a nerve entrapment syndrome. Despite extremely high prevalence in the general population, Mortons neuroma is very frequently misunderstood by patients as well as physicians. […] According to latest estimates, the prevalence of Morton Neuroma is as high as 33% in the general population. […] Women are more likely to develop Morton neuroma as compared to males. […] Mortons neuroma is ideally managed conservatively, or with Ultrasound guided ablation procedures while surgical resections are usually the preferred mode of therapy for neuromas. […] Although surgery is often a last resort, Mortons neuroma is the only form of entrapment neuropathy where surgeons resect the nerve to alleviate the symptoms of the nerve dysfunction.
  • #32 Morton neuroma | Radiology Reference Article | Radiopaedia.org
    https://radiopaedia.org/articles/morton-neuroma-1?embed_domain=hackmd.io%2525252F%25252540yipuafecsl2jsu8smr5njq%2525252Fbnjhjgjghjghjghradiopaedia-icon-144.pngfavicon.ico&lang=gb
    Morton neuromas most often occur in middle-aged individuals and are many times more common in women than men. Approximately 30% of asymptomatic middle-aged persons have radiologic findings of a Morton neuroma. […] The condition is thought to be due to chronic entrapment of the nerve by the intermetatarsal ligament.
  • #33 Interdigital Neuroma – Musculoskeletal and Connective Tissue Disorders – Merck Manual Professional Edition
    https://www.merckmanuals.com/professional/musculoskeletal-and-connective-tissue-disorders/foot-and-ankle-disorders/interdigital-neuroma
    Interdigital neuroma is a common cause of metatarsalgia. […] Neuroma of the interdigital nerve along its distal innervation near the ball of the foot develops primarily as a result of improper or constrictive footwear or, less commonly, nerve traction resulting from abnormal foot structure (eg, splayfoot deformity). […] The symptoms of interdigital neuroma are often specific, and the diagnosis is confirmed by tenderness on plantar palpation of the interdigital space and by reproduction of the radiating burning pain, often accompanied by a notable click, by squeezing the space (Mulder sign). […] Diagnose the disorder by clinical findings, including tenderness and reproduction of symptoms with palpation of the interdigital space.
  • #34 Case Study – Clinical Application of Sonography in Diagnosis and Management of Morton’s Neuroma – Sports Medicine Ultrasound Group
    https://www.ultrasoundtraining.co.uk/case-study-clinical-application-of-sonography-in-diagnosis-and-management-of-mortons-neuroma/
    Morton neuroma (MN) (peculiar painful affection) was first described in 1876 (Morton TG, 1876). The most frequent location is 3rd web space (72%), followed by 2nd web space (30%) and quite rare in 4th web space (5%), (Giakoumis M, 2013). […] The prevalence of asymptomatic MN has been reported as 33%-54% when using ultrasound (US) or magnetic resonance imaging (MRI) for diagnosis. Sonographic evidence of Morton’s neuroma is unreliable unless it is correlated with a clinical examination and reported symptoms. Clinical examination should be the gold standard for the diagnosis of a Morton’s neuroma. […] US has been championed as an efficient modality in detecting Morton’s neuroma and equal to MRI. In a study by Bianca B et al. 2015, diagnostic sensitivity for both MRI and US was calculated at 95%. Other studies demonstrated that US is more accurate than MRI for diagnosis of MN.
  • #35 Mortons Neuroma – Experts in Forefoot pain with Advanced Treatment
    https://ankleandfootcentre.com.au/metatarsalgia/mortons-neuroma/
    Interdigital neuroma occurs most commonly in the third web space (Mortons Neuroma) (72% of cases) followed by the second (30% of cases) and the fourth (5% of cases). […] At the Ankle and Foot Centre we are able to provide additional information about the presence of a Mortons neuroma with ultrasound imaging. […] The Ankle, Foot and Orthotic Centres Northcote Podiatrists can help you with all lower limb complaints, including Neuroma.
  • #36 Case Study – Clinical Application of Sonography in Diagnosis and Management of Morton’s Neuroma – Sports Medicine Ultrasound Group
    https://www.ultrasoundtraining.co.uk/case-study-clinical-application-of-sonography-in-diagnosis-and-management-of-mortons-neuroma/
    Morton neuroma (MN) (peculiar painful affection) was first described in 1876 (Morton TG, 1876). The most frequent location is 3rd web space (72%), followed by 2nd web space (30%) and quite rare in 4th web space (5%), (Giakoumis M, 2013). […] The prevalence of asymptomatic MN has been reported as 33%-54% when using ultrasound (US) or magnetic resonance imaging (MRI) for diagnosis. Sonographic evidence of Morton’s neuroma is unreliable unless it is correlated with a clinical examination and reported symptoms. Clinical examination should be the gold standard for the diagnosis of a Morton’s neuroma. […] US has been championed as an efficient modality in detecting Morton’s neuroma and equal to MRI. In a study by Bianca B et al. 2015, diagnostic sensitivity for both MRI and US was calculated at 95%. Other studies demonstrated that US is more accurate than MRI for diagnosis of MN.
  • #37 Mortons Neuroma – Experts in Forefoot pain with Advanced Treatment
    https://ankleandfootcentre.com.au/metatarsalgia/mortons-neuroma/
    Interdigital neuroma occurs most commonly in the third web space (Mortons Neuroma) (72% of cases) followed by the second (30% of cases) and the fourth (5% of cases). […] At the Ankle and Foot Centre we are able to provide additional information about the presence of a Mortons neuroma with ultrasound imaging. […] The Ankle, Foot and Orthotic Centres Northcote Podiatrists can help you with all lower limb complaints, including Neuroma.
  • #38 Morton neuroma – Knowledge @ AMBOSS
    https://www.amboss.com/us/knowledge/morton-neuroma/
    Morton neuroma is the second most common compressive neuropathy after carpal tunnel syndrome. […] The third interdigital space and nerve are involved in 87% of affected individuals. […] Epidemiological data refers to the US, unless otherwise specified.
  • #39 Morton Neuroma – StatPearls – NCBI Bookshelf
    https://www.ncbi.nlm.nih.gov/sites/books/NBK470249/
    Morton neuroma is common in middle-aged women, and the incidence is at least five times more common in females when compared to men. The exact incidence is unknown. Rarely are both feet affected. Finding two neuromas on the same foot is common. […] Morton neuroma is best managed non-surgically with an interprofessional team of healthcare professionals, including a podiatrist, orthopedic surgeon, sports physician, nurse practitioner, and primary care provider. The patient may require pain medications, but the key is changes in shoe wear. The nurse should encourage the patient to wear appropriate, well-padded, non-constrictive shoewear. Obese patients may benefit from weight loss, so a dietary consult is appropriate. The patient may benefit from physical therapy and the use of warm compresses and ice to ease the pain.
  • #40 Morton’s Neuroma | SpringerLink
    https://link.springer.com/chapter/10.1007/978-3-030-95738-4_22
    Mortons neuroma is one of the most frequent causes of metatarsalgia, which mostly affects the third interosseous space. It is usually unilateral, but even in 15-21% of the cases, it is bilateral. […] The most common symptom is pain of the neurotic type. […] Despite the fact that the diagnosis is eminently clinical, imaging studies look for thickening and/or increase in size of the interdigital plantar nerve and rule out differential diagnosis. […] The recommended studies are ultrasonography (US) and magnetic resonance imaging (MRI). […] If symptoms relapse, revision surgery through a plantar approach is recommended to allow nerve plantar branch identification and resection (more frequent cause for symptoms relapse). […] The role of MRI and ultrasound imaging in Mortons neuroma and the effect of size of lesion on symptoms.
  • #41 Morton Neuroma – StatPearls – NCBI Bookshelf
    https://www.ncbi.nlm.nih.gov/sites/books/NBK470249/
    Morton neuroma is common in middle-aged women, and the incidence is at least five times more common in females when compared to men. The exact incidence is unknown. Rarely are both feet affected. Finding two neuromas on the same foot is common. […] Morton neuroma is best managed non-surgically with an interprofessional team of healthcare professionals, including a podiatrist, orthopedic surgeon, sports physician, nurse practitioner, and primary care provider. The patient may require pain medications, but the key is changes in shoe wear. The nurse should encourage the patient to wear appropriate, well-padded, non-constrictive shoewear. Obese patients may benefit from weight loss, so a dietary consult is appropriate. The patient may benefit from physical therapy and the use of warm compresses and ice to ease the pain.
  • #42 Fact No. #6: Asymptomatic Morton’s Neuroma
    https://www.mortonsneuroma.com/blog/mortons-neuroma-facts-6-asymtompatic-mortons-neuroma/
    A study reported in the peer reviewed journal Radiology (1), explored the factors that may define the severity of symptoms of Mortons neuroma. The prevalence of asymptomatic Morton neuromas in general population is roughly 30%. […] The transverse diameter of asymptomatic neuromas is generally smaller than in patients with pain. (Approximately 3mm-7mm or an average 4.5mm as opposed to symptomatic neuromas that are usually in the range of 4mm-8 mm or an average of 5.6 mm). So statistically speaking, the larger Mortons neuromas are more likely to be painful.
  • #43 Fact No. #6: Asymptomatic Morton’s Neuroma
    https://www.mortonsneuroma.com/blog/mortons-neuroma-facts-6-asymtompatic-mortons-neuroma/
    A study reported in the peer reviewed journal Radiology (1), explored the factors that may define the severity of symptoms of Mortons neuroma. The prevalence of asymptomatic Morton neuromas in general population is roughly 30%. […] The transverse diameter of asymptomatic neuromas is generally smaller than in patients with pain. (Approximately 3mm-7mm or an average 4.5mm as opposed to symptomatic neuromas that are usually in the range of 4mm-8 mm or an average of 5.6 mm). So statistically speaking, the larger Mortons neuromas are more likely to be painful.
  • #44 Fact No. #6: Asymptomatic Morton’s Neuroma
    https://www.mortonsneuroma.com/blog/mortons-neuroma-facts-6-asymtompatic-mortons-neuroma/
    A study reported in the peer reviewed journal Radiology (1), explored the factors that may define the severity of symptoms of Mortons neuroma. The prevalence of asymptomatic Morton neuromas in general population is roughly 30%. […] The transverse diameter of asymptomatic neuromas is generally smaller than in patients with pain. (Approximately 3mm-7mm or an average 4.5mm as opposed to symptomatic neuromas that are usually in the range of 4mm-8 mm or an average of 5.6 mm). So statistically speaking, the larger Mortons neuromas are more likely to be painful.
  • #45 Morton’s Neuroma | SpringerLink
    https://link.springer.com/chapter/10.1007/978-3-319-28845-1_5427-2
    Mortons neuroma, also known as interdigital neuroma or interdigital neuritis, is a benign lesion composed of perineurial fibrosis and nerve degeneration in the intermetatarsal spaces, leading to pain in the forefoot (metatarsalgia). […] It is most commonly diagnosed in middle-aged individuals, with a relatively higher prevalence in women, possibly as a result of wearing high-heeled shoes with increased weight bearing on the forefoot, which cause repetitive compression, leading to the development lesion, which most frequently occurs in the second and third intermetatarsal spaces (Wu 1996). […] Lesions less than 5 mm in transverse diameter are often asymptomatic, noted in 30% individuals (Bencardino et al. 2000). Lesions with a transverse diameter of 5 mm or more are associated with symptoms.
  • #46 Morton’s Neuroma: Causes, Symptoms, and Treatment
    https://patient.info/foot-care/heel-and-foot-pain-plantar-fasciitis/mortons-neuroma
    About three people out of four who have Morton’s neuroma are women. It most commonly affects people between the ages of 40 and 60 but can occur at any age. […] Poorly fitting or constricting shoes can contribute to Morton’s neuroma. It is more common in women who habitually wear high-heeled shoes or in men who are required to wear tight (constrictive) footwear. It may also be more common in ballet dancers and runners. In some people there is no obvious cause. […] Morton’s neuroma is usually diagnosed by a clinician listening to the symptoms and examining the foot. Sometimes a doctor can feel the 'neuroma’, or an area of thickening in your foot, which may be tender. Pressing on the area between the long bones in your foot may show a tender spot. […] About one third of people with Morton’s neuroma get better just with changing their footwear and using metatarsal pads. Of those who choose to have surgery, about three out of four will have good results with relief of their symptoms. […] Ensuring that shoes are well fitted, low-heeled and with a wide toe area may help to prevent Morton’s neuroma.
  • #47 Morton’s Neuroma: Causes, Symptoms, and Treatment
    https://patient.info/foot-care/heel-and-foot-pain-plantar-fasciitis/mortons-neuroma
    About three people out of four who have Morton’s neuroma are women. It most commonly affects people between the ages of 40 and 60 but can occur at any age. […] Poorly fitting or constricting shoes can contribute to Morton’s neuroma. It is more common in women who habitually wear high-heeled shoes or in men who are required to wear tight (constrictive) footwear. It may also be more common in ballet dancers and runners. In some people there is no obvious cause. […] Morton’s neuroma is usually diagnosed by a clinician listening to the symptoms and examining the foot. Sometimes a doctor can feel the 'neuroma’, or an area of thickening in your foot, which may be tender. Pressing on the area between the long bones in your foot may show a tender spot. […] About one third of people with Morton’s neuroma get better just with changing their footwear and using metatarsal pads. Of those who choose to have surgery, about three out of four will have good results with relief of their symptoms. […] Ensuring that shoes are well fitted, low-heeled and with a wide toe area may help to prevent Morton’s neuroma.
  • #48 Interdigital Neuroma – Musculoskeletal and Connective Tissue Disorders – Merck Manual Professional Edition
    https://www.merckmanuals.com/professional/musculoskeletal-and-connective-tissue-disorders/foot-and-ankle-disorders/interdigital-neuroma
    Interdigital neuroma is a common cause of metatarsalgia. […] Neuroma of the interdigital nerve along its distal innervation near the ball of the foot develops primarily as a result of improper or constrictive footwear or, less commonly, nerve traction resulting from abnormal foot structure (eg, splayfoot deformity). […] The symptoms of interdigital neuroma are often specific, and the diagnosis is confirmed by tenderness on plantar palpation of the interdigital space and by reproduction of the radiating burning pain, often accompanied by a notable click, by squeezing the space (Mulder sign). […] Diagnose the disorder by clinical findings, including tenderness and reproduction of symptoms with palpation of the interdigital space.
  • #49 Morton’s Neuroma | SpringerLink
    https://link.springer.com/chapter/10.1007/978-3-030-95738-4_22
    Mortons neuroma is one of the most frequent causes of metatarsalgia, which mostly affects the third interosseous space. It is usually unilateral, but even in 15-21% of the cases, it is bilateral. […] The most common symptom is pain of the neurotic type. […] Despite the fact that the diagnosis is eminently clinical, imaging studies look for thickening and/or increase in size of the interdigital plantar nerve and rule out differential diagnosis. […] The recommended studies are ultrasonography (US) and magnetic resonance imaging (MRI). […] If symptoms relapse, revision surgery through a plantar approach is recommended to allow nerve plantar branch identification and resection (more frequent cause for symptoms relapse). […] The role of MRI and ultrasound imaging in Mortons neuroma and the effect of size of lesion on symptoms.
  • #50 Case Study – Clinical Application of Sonography in Diagnosis and Management of Morton’s Neuroma – Sports Medicine Ultrasound Group
    https://www.ultrasoundtraining.co.uk/case-study-clinical-application-of-sonography-in-diagnosis-and-management-of-mortons-neuroma/
    Morton neuroma (MN) (peculiar painful affection) was first described in 1876 (Morton TG, 1876). The most frequent location is 3rd web space (72%), followed by 2nd web space (30%) and quite rare in 4th web space (5%), (Giakoumis M, 2013). […] The prevalence of asymptomatic MN has been reported as 33%-54% when using ultrasound (US) or magnetic resonance imaging (MRI) for diagnosis. Sonographic evidence of Morton’s neuroma is unreliable unless it is correlated with a clinical examination and reported symptoms. Clinical examination should be the gold standard for the diagnosis of a Morton’s neuroma. […] US has been championed as an efficient modality in detecting Morton’s neuroma and equal to MRI. In a study by Bianca B et al. 2015, diagnostic sensitivity for both MRI and US was calculated at 95%. Other studies demonstrated that US is more accurate than MRI for diagnosis of MN.
  • #51 Case Study – Clinical Application of Sonography in Diagnosis and Management of Morton’s Neuroma – Sports Medicine Ultrasound Group
    https://www.ultrasoundtraining.co.uk/case-study-clinical-application-of-sonography-in-diagnosis-and-management-of-mortons-neuroma/
    Morton neuroma (MN) (peculiar painful affection) was first described in 1876 (Morton TG, 1876). The most frequent location is 3rd web space (72%), followed by 2nd web space (30%) and quite rare in 4th web space (5%), (Giakoumis M, 2013). […] The prevalence of asymptomatic MN has been reported as 33%-54% when using ultrasound (US) or magnetic resonance imaging (MRI) for diagnosis. Sonographic evidence of Morton’s neuroma is unreliable unless it is correlated with a clinical examination and reported symptoms. Clinical examination should be the gold standard for the diagnosis of a Morton’s neuroma. […] US has been championed as an efficient modality in detecting Morton’s neuroma and equal to MRI. In a study by Bianca B et al. 2015, diagnostic sensitivity for both MRI and US was calculated at 95%. Other studies demonstrated that US is more accurate than MRI for diagnosis of MN.
  • #52 Study of the Anatomical Association between Morton’s Neuroma and the Space Inferior to the Deep Transverse Metatarsal Ligament Using Ultrasound
    https://www.mdpi.com/2075-4418/12/6/1367
    Morton’s neuroma (MN) is a frequent condition in the general population with a prevalence of 30–33% and a female to male incidence of 4:1. […] This study has been designed as a cross-sectional descriptive epidemiological study, which was carried out between February 2020 and October 2020 in 100 patients (200 measurements) from Maria del Mar clinic (Alcazar de San Juan, Ciudad Real, Spain). […] The multivariate analysis using logistic regression, where the dependent variable is the type of patient (control and patient with MN), showed that the variables that were statistically significant (p < 0.05) were b (right and left) of the metatarsals and patient’s weight. [...] At the diagnostic level, the latest consensus document of the European Society of Radiology (2017) established US as the technique of choice for the diagnosis of MN, which points out the value of our results.
  • #53 Diagnosis of a Morton’s Neuroma – Sports Medicine Review
    https://www.sportsmedreview.com/blog/diagnosis-of-a-mortons-neuroma/
    A Morton’s neuroma should be considered in patients who are middle aged and wear tight fitting shoes (4). They are found more frequently in women (5). […] MRI and ultrasound can be used for diagnosis of a Morton’s neuroma. Both imaging modalities are accurate in diagnosis, but an ultrasound is significantly less expensive (2). […] A Morton’s neuroma is a common source of forefoot pain in patients who wear tight fitting shoes. Ultrasound evaluation is an inexpensive and easy way to diagnose a Morton’s neuroma.
  • #54 Case Study – Clinical Application of Sonography in Diagnosis and Management of Morton’s Neuroma – Sports Medicine Ultrasound Group
    https://www.ultrasoundtraining.co.uk/case-study-clinical-application-of-sonography-in-diagnosis-and-management-of-mortons-neuroma/
    Morton neuroma (MN) (peculiar painful affection) was first described in 1876 (Morton TG, 1876). The most frequent location is 3rd web space (72%), followed by 2nd web space (30%) and quite rare in 4th web space (5%), (Giakoumis M, 2013). […] The prevalence of asymptomatic MN has been reported as 33%-54% when using ultrasound (US) or magnetic resonance imaging (MRI) for diagnosis. Sonographic evidence of Morton’s neuroma is unreliable unless it is correlated with a clinical examination and reported symptoms. Clinical examination should be the gold standard for the diagnosis of a Morton’s neuroma. […] US has been championed as an efficient modality in detecting Morton’s neuroma and equal to MRI. In a study by Bianca B et al. 2015, diagnostic sensitivity for both MRI and US was calculated at 95%. Other studies demonstrated that US is more accurate than MRI for diagnosis of MN.
  • #55 Rheumatoid nodule presenting as Morton’s neuroma | Journal of Orthopaedics and Traumatology | Full Text
    https://jorthoptraumatol.springeropen.com/articles/10.1007/s10195-012-0215-x
    Among 101 feet that presented with symptoms and signs similar to Mortons neuroma, intermetatarsal rheumatoid nodules were found in five feet (three patients). […] Rheumatoid synovitis and nodules producing symptoms mimicking Mortons neuroma have been reported in the literature, but most of the cases were found in previously diagnosed rheumatoid arthritis patients. […] The incidence of interdigital neuroma in rheumatoid arthritis patients was reported to be 1 in 520, with a female preponderance. […] Awerbuch et al. suggested seeking histological evidence of rheumatoid disease in all tissues excised in the surgical treatment of Mortons neuroma, as they believed that rheumatoid disease is the basic etiology in a significant number of patients. […] We therefore suggest that a nodule of rheumatoid origin should be considered in the differential diagnosis of Mortons neuroma, not only in patients with a known history of rheumatoid arthritis but also in patients who present with symptoms of Mortons neuroma and have atypical intraoperative findings.
  • #56 Rheumatoid nodule presenting as Morton’s neuroma | Journal of Orthopaedics and Traumatology | Full Text
    https://jorthoptraumatol.springeropen.com/articles/10.1007/s10195-012-0215-x
    Among 101 feet that presented with symptoms and signs similar to Mortons neuroma, intermetatarsal rheumatoid nodules were found in five feet (three patients). […] Rheumatoid synovitis and nodules producing symptoms mimicking Mortons neuroma have been reported in the literature, but most of the cases were found in previously diagnosed rheumatoid arthritis patients. […] The incidence of interdigital neuroma in rheumatoid arthritis patients was reported to be 1 in 520, with a female preponderance. […] Awerbuch et al. suggested seeking histological evidence of rheumatoid disease in all tissues excised in the surgical treatment of Mortons neuroma, as they believed that rheumatoid disease is the basic etiology in a significant number of patients. […] We therefore suggest that a nodule of rheumatoid origin should be considered in the differential diagnosis of Mortons neuroma, not only in patients with a known history of rheumatoid arthritis but also in patients who present with symptoms of Mortons neuroma and have atypical intraoperative findings.
  • #57 Rheumatoid nodule presenting as Morton’s neuroma | Journal of Orthopaedics and Traumatology | Full Text
    https://jorthoptraumatol.springeropen.com/articles/10.1007/s10195-012-0215-x
    Among 101 feet that presented with symptoms and signs similar to Mortons neuroma, intermetatarsal rheumatoid nodules were found in five feet (three patients). […] Rheumatoid synovitis and nodules producing symptoms mimicking Mortons neuroma have been reported in the literature, but most of the cases were found in previously diagnosed rheumatoid arthritis patients. […] The incidence of interdigital neuroma in rheumatoid arthritis patients was reported to be 1 in 520, with a female preponderance. […] Awerbuch et al. suggested seeking histological evidence of rheumatoid disease in all tissues excised in the surgical treatment of Mortons neuroma, as they believed that rheumatoid disease is the basic etiology in a significant number of patients. […] We therefore suggest that a nodule of rheumatoid origin should be considered in the differential diagnosis of Mortons neuroma, not only in patients with a known history of rheumatoid arthritis but also in patients who present with symptoms of Mortons neuroma and have atypical intraoperative findings.
  • #58 Mortons Neuroma
    https://podiapaedia.org/wiki/neurology/nerve-entrapment/mortons-neuroma/
    Common problem 9.3% of foot complaints in one clinic. […] Middle aged women most commonly affected. […] 40% of patients seen at one clinic that presented what was a diagnosis of Mortons interdigital neuroma either had diagnosed rheumatoid arthritis at the time or later developed the disease. […] Appears to be more common in females in 4th to 6th decade (? Role of footwear).
  • #59 Rheumatoid nodule presenting as Morton’s neuroma | Journal of Orthopaedics and Traumatology | Full Text
    https://jorthoptraumatol.springeropen.com/articles/10.1007/s10195-012-0215-x
    Among 101 feet that presented with symptoms and signs similar to Mortons neuroma, intermetatarsal rheumatoid nodules were found in five feet (three patients). […] Rheumatoid synovitis and nodules producing symptoms mimicking Mortons neuroma have been reported in the literature, but most of the cases were found in previously diagnosed rheumatoid arthritis patients. […] The incidence of interdigital neuroma in rheumatoid arthritis patients was reported to be 1 in 520, with a female preponderance. […] Awerbuch et al. suggested seeking histological evidence of rheumatoid disease in all tissues excised in the surgical treatment of Mortons neuroma, as they believed that rheumatoid disease is the basic etiology in a significant number of patients. […] We therefore suggest that a nodule of rheumatoid origin should be considered in the differential diagnosis of Mortons neuroma, not only in patients with a known history of rheumatoid arthritis but also in patients who present with symptoms of Mortons neuroma and have atypical intraoperative findings.
  • #60 Rheumatoid nodule presenting as Morton’s neuroma | Journal of Orthopaedics and Traumatology | Full Text
    https://jorthoptraumatol.springeropen.com/articles/10.1007/s10195-012-0215-x
    Among 101 feet that presented with symptoms and signs similar to Mortons neuroma, intermetatarsal rheumatoid nodules were found in five feet (three patients). […] Rheumatoid synovitis and nodules producing symptoms mimicking Mortons neuroma have been reported in the literature, but most of the cases were found in previously diagnosed rheumatoid arthritis patients. […] The incidence of interdigital neuroma in rheumatoid arthritis patients was reported to be 1 in 520, with a female preponderance. […] Awerbuch et al. suggested seeking histological evidence of rheumatoid disease in all tissues excised in the surgical treatment of Mortons neuroma, as they believed that rheumatoid disease is the basic etiology in a significant number of patients. […] We therefore suggest that a nodule of rheumatoid origin should be considered in the differential diagnosis of Mortons neuroma, not only in patients with a known history of rheumatoid arthritis but also in patients who present with symptoms of Mortons neuroma and have atypical intraoperative findings.
  • #61 Morton Neuroma – StatPearls – NCBI Bookshelf
    https://www.ncbi.nlm.nih.gov/sites/books/NBK470249/
    Morton neuroma is common in middle-aged women, and the incidence is at least five times more common in females when compared to men. The exact incidence is unknown. Rarely are both feet affected. Finding two neuromas on the same foot is common. […] Morton neuroma is best managed non-surgically with an interprofessional team of healthcare professionals, including a podiatrist, orthopedic surgeon, sports physician, nurse practitioner, and primary care provider. The patient may require pain medications, but the key is changes in shoe wear. The nurse should encourage the patient to wear appropriate, well-padded, non-constrictive shoewear. Obese patients may benefit from weight loss, so a dietary consult is appropriate. The patient may benefit from physical therapy and the use of warm compresses and ice to ease the pain.
  • #62 Morton’s Neuroma: Causes, Symptoms, and Treatment
    https://patient.info/foot-care/heel-and-foot-pain-plantar-fasciitis/mortons-neuroma
    About three people out of four who have Morton’s neuroma are women. It most commonly affects people between the ages of 40 and 60 but can occur at any age. […] Poorly fitting or constricting shoes can contribute to Morton’s neuroma. It is more common in women who habitually wear high-heeled shoes or in men who are required to wear tight (constrictive) footwear. It may also be more common in ballet dancers and runners. In some people there is no obvious cause. […] Morton’s neuroma is usually diagnosed by a clinician listening to the symptoms and examining the foot. Sometimes a doctor can feel the 'neuroma’, or an area of thickening in your foot, which may be tender. Pressing on the area between the long bones in your foot may show a tender spot. […] About one third of people with Morton’s neuroma get better just with changing their footwear and using metatarsal pads. Of those who choose to have surgery, about three out of four will have good results with relief of their symptoms. […] Ensuring that shoes are well fitted, low-heeled and with a wide toe area may help to prevent Morton’s neuroma.
  • #63 Morton’s Neuroma: Causes, Treatment, and More
    https://www.healthline.com/health/mortons-neuroma
    Mortons neuroma is a benign but painful condition that affects the ball of the foot. […] It most commonly occurs in middle-aged people, especially middle-aged women. […] Mortons neuroma is often associated with: flat feet, high arches, bunions, hammer toes. […] Mortons neuroma is treatable, but if its not treated promptly it can lead to permanent nerve damage. […] Conservative treatment brings people with Mortons neuroma relief 80 percent of the time. […] There are few long-term studies of surgical treatment results, but the Cleveland Clinic reports that surgery effectively relieves or reduces symptoms in 75 to 85 percent of cases. […] Statistics comparing the results of different treatments are limited.
  • #64
    https://www.footcaremd.org/conditions-treatments/toes/mortons-neuroma
    Morton’s neuroma most frequently develops between the second/third and third/fourth toes. It often occurs in response to irritation, trauma, or excessive pressure, and is more common in women. […] Several studies have shown that a combination of shoe changes, oral anti-inflammatory medications, orthotics, and/or cortisone injections will provide relief in more than 80% of people with Morton’s neuroma.
  • #65 Morton’s Neuroma
    http://www.bofas.org.uk/hyperbook/forefoot/mortons-neuroma
    Mortons neuromas are identified in up to 33% of asymptomatic feet on MRI, emphasising the importance of thorough clinical assessment […] In the largest meta-analysis to date, the only conservative treatments with sufficient evidence to recommend are: manipulation / physiotherapy and steroid injection. […] No consensus exists on whether injections should be blind or US-guided. […] Other surgical treatments have been trialled: neurolysis; nerve decompression by division of intermetatarsal ligament reasonable reported results but lacking long-term data; increased resurgence, particularly in Europe.
  • #66 Morton’s Neuroma
    http://www.bofas.org.uk/hyperbook/forefoot/mortons-neuroma
    Mortons neuromas are identified in up to 33% of asymptomatic feet on MRI, emphasising the importance of thorough clinical assessment […] In the largest meta-analysis to date, the only conservative treatments with sufficient evidence to recommend are: manipulation / physiotherapy and steroid injection. […] No consensus exists on whether injections should be blind or US-guided. […] Other surgical treatments have been trialled: neurolysis; nerve decompression by division of intermetatarsal ligament reasonable reported results but lacking long-term data; increased resurgence, particularly in Europe.
  • #67 Morton’s Neuroma – Harvard Health
    https://www.health.harvard.edu/a_to_z/mortons-neuroma-a-to-z
    A Morton’s neuroma is a benign (noncancerous) swelling along a nerve in the foot that carries sensations from the toes. […] The condition is much more common in women than men, probably as a result of wearing high-heeled, narrow-toed shoes. […] Being overweight also increases the risk of a Morton’s neuroma. […] More than 80% of people with a Morton’s neuroma will respond to conservative treatment. For the minority of people who have persistent, disabling symptoms, surgery may be an option.
  • #68 Morton’s Neuroma – OrthoInfo – AAOS
    https://orthoinfo.aaos.org/en/diseases–conditions/mortons-neuroma
    Morton’s neuromas are around 8 times more common in women than men and typically affect people between the ages of 30 and 60, though they can occur outside of this age range as well. […] Studies have shown that many people can achieve lasting relief with a combination of shoe wear modifications, orthoses, anti-inflammatory medications (e.g., ibuprofen or naproxen), and/or corticosteroid injections. […] Surgical intervention with neurectomy (removal of part of the nerve) or decompression of the nerve has the highest success rate, with most studies reporting an 80 to 95% success rate.
  • #69 An Overview of Morton’s Neuroma
    https://www.facstl.com/blog/foot-health/overview-mortons-neuroma/
    Mortons neuroma is not a rare condition and is about eight times more common in women than in men and mainly impacts individuals ages 30 to 60 years. […] Potential risk factors for the nerve entrapment syndrome include: […] Podiatrists consider Mortons neuroma surgery to be a particularly reliable treatment option, as data demonstrates an 80%-95% success rate.
  • #70 Morton’s Neuroma: Interdigital Perineural Fibrosis : Wheeless’ Textbook of Orthopaedics
    https://www.wheelessonline.com/orthopaedics/mortons-neuroma-interdigital-perineural-fibrosis/
    – occurs most often in middle aged women (78 % are women); […] – the success of conservative treatment decreases with the length of time that the symptoms have been present; […] – with true interdigital neuroma, most patients will remain symptomatic despite conservative care; […] – informed consent necessary: tell your patients about 20 % mediocre to bad results […] – failure of conservative treatment and temporary improvement with Xylocaine/cortisone infiltration (try not to use cortisone in athletes to prevent fat pad atrophy/degeneration of volar plate and collateral ligaments); […] – overall satisfaction was rated as excellent or good by 56 (85%) of the 66 patients; […] – 46 (65%) of the seventy-one feet were pain-free at the time of final follow-up; […] – while major activity restrictions following surgery were uncommon, mild or major shoe-wear restrictions were noted by 46 of the 66 patients;
  • #71 Morton’s Neuroma | SpringerLink
    https://link.springer.com/chapter/10.1007/978-3-030-95738-4_22
    Mortons neuroma is one of the most frequent causes of metatarsalgia, which mostly affects the third interosseous space. It is usually unilateral, but even in 15-21% of the cases, it is bilateral. […] The most common symptom is pain of the neurotic type. […] Despite the fact that the diagnosis is eminently clinical, imaging studies look for thickening and/or increase in size of the interdigital plantar nerve and rule out differential diagnosis. […] The recommended studies are ultrasonography (US) and magnetic resonance imaging (MRI). […] If symptoms relapse, revision surgery through a plantar approach is recommended to allow nerve plantar branch identification and resection (more frequent cause for symptoms relapse). […] The role of MRI and ultrasound imaging in Mortons neuroma and the effect of size of lesion on symptoms.
  • #72 Morton’s Neuroma: Causes, Treatment, and More
    https://www.healthline.com/health/mortons-neuroma
    Mortons neuroma is a benign but painful condition that affects the ball of the foot. […] It most commonly occurs in middle-aged people, especially middle-aged women. […] Mortons neuroma is often associated with: flat feet, high arches, bunions, hammer toes. […] Mortons neuroma is treatable, but if its not treated promptly it can lead to permanent nerve damage. […] Conservative treatment brings people with Mortons neuroma relief 80 percent of the time. […] There are few long-term studies of surgical treatment results, but the Cleveland Clinic reports that surgery effectively relieves or reduces symptoms in 75 to 85 percent of cases. […] Statistics comparing the results of different treatments are limited.
  • #73 Effect of surgical approach on the treatment of Morton’s neuroma: a systematic review and meta-analysis | Journal of Foot and Ankle Research | Full Text
    https://jfootankleres.biomedcentral.com/articles/10.1186/s13047-023-00660-w
    According to reports, the age standardized incidence rate of Mortons neuroma is 50.2 in males and 87.5 in females per 100,000 individuals. […] The purpose of this systematic review and meta-analysis was to compare the surgical resection of Mortons neuroma via dorsal and plantar approaches. […] Our study found that there is insufficient consistent, standardized information to provide a comparison of the two approaches. […] It provides researchers a hypothesis that the frequency of adverse events in the treatment of Mortons neuroma by dorsal and plantar approaches may be the similar, but the types are different, based on the current small, low-level evidence.
  • #74 Morton’s Neuroma: Causes, Symptoms & Treatment
    https://my.clevelandclinic.org/health/diseases/15118-mortons-neuroma
    Mortons neuromas are common. Experts estimate that around 1 in 3 people has a Mortons neuroma at some point in their life. […] If a Mortons neuroma isnt treated, it can cause nerve damage or chronic pain in your affected foot. Visit a healthcare provider as soon as you notice any Mortons neuroma symptoms. The sooner a provider diagnoses and treats a Mortons neuroma, the less likely it is youll experience complications.
  • #75 Morton’s Neuroma: Causes, Symptoms & Treatment
    https://my.clevelandclinic.org/health/diseases/15118-mortons-neuroma
    Mortons neuromas are common. Experts estimate that around 1 in 3 people has a Mortons neuroma at some point in their life. […] If a Mortons neuroma isnt treated, it can cause nerve damage or chronic pain in your affected foot. Visit a healthcare provider as soon as you notice any Mortons neuroma symptoms. The sooner a provider diagnoses and treats a Mortons neuroma, the less likely it is youll experience complications.
  • #76 Morton’s Neuroma: Symptoms, Causes, Diagnosis, and Treatment
    https://www.webmd.com/women/mortons-neuroma
    Morton’s neuroma is common, affecting an estimated 1 in every 3 people during their lifetime. […] Women are more likely than men to get Morton’s neuroma. Why? You can probably guess: High-heeled shoes are often to blame, because they put pressure on the feet. […] If you take these steps and your feet still hurt after a couple of weeks, see your doctor. Finding the problem fast can make it much easier to deal with. Left untreated, a Morton’s neuroma can grow bigger and even lead to permanent nerve damage. […] You can’t always prevent Morton’s neuroma. But some simple precautions will help you keep problems away. […] For most people, changes in footwear and activity, shoe inserts, and/or shots are enough to bring long-lasting relief from symptoms of Morton’s neuroma. […] Morton’s neuromas won’t go away on their own, although treatment and lifestyle modifications ease symptoms for most people. The condition tends to come and go.
  • #77 Morton’s Neuroma: Symptoms, Causes, Diagnosis, and Treatment
    https://www.webmd.com/women/mortons-neuroma
    Morton’s neuroma is common, affecting an estimated 1 in every 3 people during their lifetime. […] Women are more likely than men to get Morton’s neuroma. Why? You can probably guess: High-heeled shoes are often to blame, because they put pressure on the feet. […] If you take these steps and your feet still hurt after a couple of weeks, see your doctor. Finding the problem fast can make it much easier to deal with. Left untreated, a Morton’s neuroma can grow bigger and even lead to permanent nerve damage. […] You can’t always prevent Morton’s neuroma. But some simple precautions will help you keep problems away. […] For most people, changes in footwear and activity, shoe inserts, and/or shots are enough to bring long-lasting relief from symptoms of Morton’s neuroma. […] Morton’s neuromas won’t go away on their own, although treatment and lifestyle modifications ease symptoms for most people. The condition tends to come and go.
  • #78 Morton’s Neuroma: Causes, Symptoms, and Treatment
    https://patient.info/foot-care/heel-and-foot-pain-plantar-fasciitis/mortons-neuroma
    About three people out of four who have Morton’s neuroma are women. It most commonly affects people between the ages of 40 and 60 but can occur at any age. […] Poorly fitting or constricting shoes can contribute to Morton’s neuroma. It is more common in women who habitually wear high-heeled shoes or in men who are required to wear tight (constrictive) footwear. It may also be more common in ballet dancers and runners. In some people there is no obvious cause. […] Morton’s neuroma is usually diagnosed by a clinician listening to the symptoms and examining the foot. Sometimes a doctor can feel the 'neuroma’, or an area of thickening in your foot, which may be tender. Pressing on the area between the long bones in your foot may show a tender spot. […] About one third of people with Morton’s neuroma get better just with changing their footwear and using metatarsal pads. Of those who choose to have surgery, about three out of four will have good results with relief of their symptoms. […] Ensuring that shoes are well fitted, low-heeled and with a wide toe area may help to prevent Morton’s neuroma.
  • #79 Morton’s Neuroma (Intermetatarsal Neuroma)
    https://www.foothealthfacts.org/conditions/morton-s-neuroma-(intermetatarsal-neuroma)
    Morton’s Neuroma is the most common neuroma in the foot, which occurs between the third and fourth toes. […] The best time to see your foot and ankle surgeon is early in the development of symptoms. Early diagnosis of a Mortons neuroma greatly lessens the need for more invasive treatments and may help you avoid surgery. […] The American College of Foot and Ankle Surgeons (ACFAS) warns female runners that the combination of wearing narrow, pointed-toed shoes at work and the pounding their feet endure from running may increase the risk of developing Morton’s neuroma.
  • #80 Morton’s Neuroma (Intermetatarsal Neuroma)
    https://www.foothealthfacts.org/conditions/morton-s-neuroma-(intermetatarsal-neuroma)
    Morton’s Neuroma is the most common neuroma in the foot, which occurs between the third and fourth toes. […] The best time to see your foot and ankle surgeon is early in the development of symptoms. Early diagnosis of a Mortons neuroma greatly lessens the need for more invasive treatments and may help you avoid surgery. […] The American College of Foot and Ankle Surgeons (ACFAS) warns female runners that the combination of wearing narrow, pointed-toed shoes at work and the pounding their feet endure from running may increase the risk of developing Morton’s neuroma.