Materiały źródłowe

• #1 Radiation enteritis

  https://johnsonmemorial.org/jmh-health/disease-conditions/con-20248518

  Radiation enteritis is inflammation of the intestines that occurs after radiation therapy. […] Radiation enteritis occurs because radiation therapy can cause irritation of the intestines. […] The risk of radiation enteritis is higher in people undergoing radiation treatments for cancers in the belly and the pelvis.

• #2 HIE Multimedia – Radiation enteritis

  https://adamcertificationdemo.adam.com/content.aspx?productid=117&pid=1&gid=000300

  Radiation enteritis is damage to the lining of the intestines (bowels) caused by radiation therapy, which is used for some types of cancer treatment. […] Radiation therapy uses high-powered x-rays, particles, or radioactive seeds to kill cancer cells. If directed to the belly or pelvic area, the therapy may also damage healthy cells in the lining of the intestines. […] People at risk may include people with cervical, pancreatic, prostate, uterine, or colon or rectal cancer.

• #3 Radiation Enteritis – StatPearls – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/sites/books/n/statpearls/article-28177/

  Radiation enteritis is an unavoidable side effect of radiotherapy, although its development is highly variable, depending on the duration, dosage, and gut sensitivity to radiation. […] Radiation enteritis is very common; studies have reported a permanent change in bowel habits in 90% of patients that undergo pelvic radiotherapy. […] Chronic radiation enteritis occurs in approximately 5% to 55% of patients post-radiotherapy. […] The repetitive injuries caused to the intestinal mucosa by ionizing radiation, as well as its complex mechanism of healing, are proposed to cause radiation enteritis. […] Radiation enteritis is an unavoidable side effect of radiotherapy; however, its development is highly variable. […] It is becoming more common with the advent of new treatment regimens for different cancers including radiotherapy.

• #4 Radiation Enteritis: Treatment & Management

  https://my.clevelandclinic.org/health/diseases/22846-radiation-enteritis

  Radiation enteritis happens when radiation damages sensitive tissue in your intestines. It may occur during treatment or months after you’re finished. Some people experience mild symptoms, while others have long-lasting discomfort and complications. […] Radiation enteritis is a condition that occurs when radiation therapy causes damage to your intestines. Radiation therapy uses radioactive substances to destroy abnormal cells. It’s a common treatment for cancer and certain blood disorders. […] The condition can be acute or chronic: Acute radiation enteritis occurs while you’re undergoing radiation therapy. Symptoms typically go away in a few weeks. Chronic radiation enteritis develops months to years after completing treatment. Symptoms stay with you for a long time and can lead to complications.

• #5 Research progress and treatment of radiation enteritis and gut microbiota

  https://www.e-roj.org/journal/view.php?doi=10.3857/roj.2023.00346

  Radiation enteritis, which refers to radiation therapy-induced injury to the intestinal epithelium, with or without mild inflammation, is one of the common complications after radiation therapy in patients with pelvic malignancy. […] Radiation enteritis can be divided into acute radiation enteritis and chronic radiation enteritis according to the time and course of symptoms. […] The basic pathological changes include two aspects: intestinal mucosal injury caused by radiation and vascular connective tissue injury caused by radiation vascular endothelial cells. […] Existing research results show that the gut microbiota of patients with radiation enteritis is significantly translocated, the number of Actinobacteriota and Proteobacteria is significantly increased, and many conditional pathogenic bacteria, such as Enterococcus and Enterobacterales, are included.

• #6 Radiation enteritis: What it is, symptoms, causes, and more

  https://www.medicalnewstoday.com/articles/radiation-enteritis

  Radiation enteritis is inflammation of the intestines that may occur in people undergoing radiation therapy. It is more common in people receiving radiotherapy on the abdomen, rectum, and pelvis. […] Radiation enteritis is relatively common in people undergoing radiation therapy. According to research, about 90% of people receiving pelvic radiation develop it while receiving this type of cancer treatment. […] Chronic radiation enteritis is less common. It develops in 555% of people after cancer treatment ends. […] Radiotherapy can cause cell death and inflammation in the lining of the intestines. It may also trigger the activation of a gene that stimulates collagen and fibronectin genes, which can promote fibrosis (thickening of connective tissue) and other complications. […] Radiation therapy also has an effect on gut flora. It reduces the diversity of gut bacteria, increasing the risk of radiation enteritis and worsening its symptoms. […] Radiation enteritis is more likely to occur in people who have received high doses of radiation for cancer treatment to large areas of their intestines and abdomen. Receiving chemotherapy alongside radiation therapy can increase a persons risk of developing this condition.

• #7 Radiation Enteritis – StatPearls – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK526032/

  Radiation enteritis is an unavoidable side effect of radiotherapy, although its development is highly variable, depending on the duration, dosage, and gut sensitivity to radiation. […] Radiation enteritis is very common; studies have reported a permanent change in bowel habits in 90% of patients that undergo pelvic radiotherapy. […] Chronic radiation enteritis occurs in approximately 5% to 55% of patients post-radiotherapy. […] The repetitive injuries caused to the intestinal mucosa by ionizing radiation, as well as its complex mechanism of healing, are proposed to cause radiation enteritis. […] The most characteristic pathologic changes observed are fibrosis and obliterative endarteritis in the intestinal epithelium. […] Radiation enteritis is an unavoidable side effect of radiotherapy; however, its development is highly variable. […] It is becoming more common with the advent of new treatment regimens for different cancers including radiotherapy.

• #8 Radiation Enteritis: Treatment & Management

  https://my.clevelandclinic.org/health/diseases/22846-radiation-enteritis

  Radiation enteritis is far less common than it used to be. When older techniques of radiation therapy were delivered to your abdomen or pelvis, up to half of the people undergoing treatment could develop radiation enteritis. With modern techniques of radiation therapy, your risk of chronic radiation enteritis is much lower. […] Some people face a higher risk due to: Conditions that decrease blood flow to their intestines, such as diabetes and high blood pressure. Existing tissue irritation due to conditions like pelvic inflammatory disease. Other treatments that destroy cells, such as chemotherapy. Poor nutrition. Smoking and other forms of tobacco use. Tissue damage from prior abdominal surgeries. […] Treatment typically requires regular exposure to radioactive substances for several weeks. When radiation reaches healthy cells, it causes inflammation and tissue damage. Cells in the lining of your intestines are more sensitive to the effects of radiation.

• #9 Radiation Enteritis and Proctitis: Practice Essentials, Pathophysiology, Etiology

  https://emedicine.medscape.com/article/197483-overview

  Radiation injury to the small and large bowel is due to damage to the lipid layer of the cell membrane, proteins, and cellular DNA. The effects are most marked in tissues containing cells with a high mitotic rate. […] Patient-related factors and the method of RT administration may intensify the effects of radiation-induced intestinal injury. Patient-related risk factors that are associated with an increased risk of radiation-induced enteropathy include the following: Advanced patient age, Prior abdominal surgery leading to intraperitoneal adhesions – Adhesions fix portions of the small or large intestine in the radiated field, History of pelvic inflammatory disease, Hypertension, Diabetes mellitus, Thin physique, Administration of chemotherapy, Other risk factors (eg, collagen vascular diseases, xeroderma pigmentosum, Cockayne syndrome).

• #10 Radiation Enteritis – Clinical Tree

  https://clinicalpub.com/radiation-enteritis/

  The first record of radiation enteritis was described in 1897 and involved transient symptoms of pain and diarrhea that correlated with radiation exposure. […] Fifty to 70% of patients with malignancy undergo radiation therapy. Symptoms of acute radiation enteritis (ARE) are reported in a majority of patients. […] The incidence of chronic radiation enteritis (CRE) is reported between 1.2% and 15% of patients undergoing radiation therapy and appears within months and up to decades after completion of treatment. […] Because more patients are receiving radiation treatment and living longer, an increasing number of patients are at risk for CRE. […] Ionizing radiation (IR) consists of photon-based (x-rays and gamma rays) or particle radiation. […] High-energy photons create ionizing electrons that then directly break chemical bonds.

• #11 Radiation Enteritis | 5-Minute Clinical Consult

  https://www.unboundmedicine.com/5minute/view/5-Minute-Clinical-Consult/117441/1.0/Radiation_Enteritis

  Radiation enteritis (RE) is an inflammatory injury to the large and small intestines resulting from radiation therapy (RT). […] Radiation injury activates intracellular mechanisms which alter cell division, leading to inflammation or cell death. Injury likely mediated indirectly by free-radical release, affecting DNA repair. Microvascular endothelial injury may also contribute. […] Acute RE: multifactorial. The cytotoxic effects of RT suppress the Na+/K+ pump in rapidly dividing intestinal epithelial cells. A relative lactose intolerance ensues, and intestinal motility is affected. This causes mucosal atrophy and inflammation leading to fluid and nutrient loss and translocation of gut bacteria with subsequent bacterial overgrowth. The endothelium of the intestinal microvasculature is also impacted, altering local thrombogenesis. […] Chronic RE: Progressive obliterative endarteritis (an occlusive vasculitis) causes tissue ischemia, leading to submucosal fibrosis and worsening ischemia.

• #12 Diagnosis and management of chronic radiation enteritis – UpToDate

  https://www.uptodate.com/contents/diagnosis-and-management-of-chronic-radiation-enteritis/print

  Injury to the intestines can occur following radiation therapy for cancer. It usually develops three or more months after radiation therapy. Chronic radiation enteritis is due to an obliterative arteritis that leads to intestinal ischemia, which can result in stricture, ulceration, fibrosis, and occasionally fistula formation. […] The pathogenesis, clinical manifestations, and risk factors for chronic radiation enteritis and other radiation-related gastrointestinal toxicities are discussed separately. […] The diagnosis of chronic radiation enteritis is suspected in patients with nausea, vomiting, abdominal pain, diarrhea, or lower gastrointestinal bleeding three or more months after completion of radiation therapy. […] The patient’s prior radiation treatment should be reviewed to determine the cumulative dose, dose per fraction, proximity of sensitive tissues and organs, and other cancer treatments (eg, abdominal surgery, concurrent chemotherapy) that can increase the risk of radiation enteritis.

• #13 Radiation Enteritis and Proctocolitis | Abdominal Key

  https://abdominalkey.com/radiation-enteritis-and-proctocolitis/

  Patients who experience extreme symptoms of acute radiation injury have a higher risk of the development of chronic radiation enteritis, which is called consequential late effect. […] Comorbid factors that increase the risk of radiation bowel injury include collagen vascular diseases, inflammatory bowel disease, human immunodeficiency virus infection, and a history of vascular occlusive disease, such as hypertension, diabetes, smoking, atherosclerosis, and cardiovascular disease. It is hypothesized that thinner patients with a smaller anterior-posterior diameter have an increased risk of intestinal toxicity.

• #14 Research progress and treatment of radiation enteritis and gut microbiota

  https://www.e-roj.org/journal/view.php?doi=10.3857/roj.2023.00346

  Radiation enteritis is a kind of intestinal radiation injury in patients with pelvic and retroperitoneal malignancies after radiotherapy, and its occurrence and development process are very complicated. […] At present, studies have confirmed that intestinal microecological imbalance is an important factor in the formation of this disease. […] Abdominal radiation causes changes in the composition of the flora and a decrease in its diversity, which is mainly manifested by a decrease in beneficial bacterial species such as Lactobacilli and Bifidobacteria. […] Intestinal dysbacteriosis aggravates radiation enteritis, weakens the function of the intestinal epithelial barrier, and promotes the expression of inflammatory factors, thereby aggravating the occurrence of enteritis. […] Given the role of the microbiome in radiation enteritis, we suggest that the gut microbiota may be a potential biomarker for the disease.

• #15 Research progress and treatment of radiation enteritis and gut microbiota

  https://www.e-roj.org/journal/view.php?doi=10.3857/roj.2023.00346

  Radiation enteritis, which refers to radiation therapy-induced injury to the intestinal epithelium, with or without mild inflammation, is one of the common complications after radiation therapy in patients with pelvic malignancy. […] Radiation enteritis can be divided into acute radiation enteritis and chronic radiation enteritis according to the time and course of symptoms. […] The basic pathological changes include two aspects: intestinal mucosal injury caused by radiation and vascular connective tissue injury caused by radiation vascular endothelial cells. […] Existing research results show that the gut microbiota of patients with radiation enteritis is significantly translocated, the number of Actinobacteriota and Proteobacteria is significantly increased, and many conditional pathogenic bacteria, such as Enterococcus and Enterobacterales, are included.

• #16 Radiation-induced enteritis | Radiology Reference Article | Radiopaedia.org

  https://radiopaedia.org/articles/radiation-induced-enteritis-1?lang=us

  Radiation-induced enteritis is a small bowel pathology resulting from toxic effects of radiotherapy on the small bowel wall and vasculature. […] 5-15% of patients treated with radiotherapy (usually 4500 cGy) develop chronic radiation enteropathy. […] In the acute phase, radiation affects bowel mucosa causing cell death with ulceration. It also causes inflammation with mucosal and submucosal edema. In the subacute and chronic phases healing and fibrosis occurs. Additionally, radiation induces endarteritis obliterans, which results in a state of chronic mesenteric ischemia leading to bowel strictures. […] Risk factors include adhesions from previous abdominal surgery, peritonitis prior to radiation therapy, high radiation dose, risk factors for atherosclerosis; hypertension and diabetes mellitus, and chemotherapy.

• #17 radiation enteritis

  https://www.aboutcancer.com/radiation_enteritis_utd_807.htm

  Chronic radiation enteritis is a complication of radiation therapy for cancer, most commonly for rectal, prostate and pelvic malignancies. […] Chronic radiation enteritis usually develops only after large doses of radiation therapy have been delivered (4500 to 5500 cGY); it is uncommon at lower doses. […] Intestinal injury is believed to be related to oxidative damage caused by the formation of free radicals. […] The precise mechanisms leading from oxidative damage to the histologic and morphologic abnormalities described above are incompletely understood. […] One model suggests that fibrosis develops from the initial mucosal injury. […] Another theory suggests that fibrosis develops in connective tissues where radiation has caused a decrease in cell turnover and a low rate of proliferation.

• #18 Radiation Enteritis – Clinical Tree

  https://clinicalpub.com/radiation-enteritis/

  The role of oxygen is critical for the effects of free radicals to be effective. […] Hypoxia is one cause of radiation treatment failure. […] DNA damage is the hallmark of radiation therapy. […] However, IR causes complex damage consisting of 15 to 20 double-strand breaks per cell per Gy. […] Risk factors for radiation enteritis include treatment volume; total dose; fractionation dose and schedules; combined surgical and chemotherapeutic modalities; medical comorbidities, such as vascular, connective tissue, and inflammatory bowel diseases and human immunodeficiency virus (HIV); and genetic susceptibility, such as single nucleotide polymorphisms (SNPs) and ataxia telangiectasia. […] Prior laparotomy is also a risk factor for CRE, and studies have shown a 4.25 increased rate of late gastrointestinal complications in irradiated patients.

• #19 Radiation Enteritis and Proctitis: Practice Essentials, Pathophysiology, Etiology

  https://emedicine.medscape.com/article/197483-overview

  Analysis of multiple risk factors for predictive value demonstrated that multiple laparotomies, hypertension, and thin physique had the highest correlation with the development of radiation enteritis. […] Administration of chemotherapy with RT correlates with an increased incidence of radiation-related intestinal damage. Several studies have documented this effect as well as the recall phenomenon, in which RT followed with chemotherapy leads to a recurrence of the symptoms of radiation-induced intestinal injury. […] The degree of intestinal injury is directly related to the total radiation dose, the fractionation, and the distribution of the dose in tissues peripheral to the target area. […] Excessive exposure of adjacent normal tissue to radiation also contributes to the development of radiation-induced enteropathy.

• #20 Radiation Enteritis – Clinical Tree

  https://clinicalpub.com/radiation-enteritis/

  The degree of normal tissue toxicity in the small bowel depends not only on the dose of radiation but also on the amount of bowel irradiated. […] Other risk factors include euthyroid sick syndrome, which consists of low triiodothyronine (T 3 ) levels. […] A multivariate analysis found that chemotherapy was associated with CRE (odds ratio [OR] = 3.59, 1.20 to 10.73). […] ARE has also been associated with the development of subsequent CRE. […] CRE accounts for the major morbidity of IR. […] Intestinal failure can be due to malabsorption secondary to anatomic SBS or functional SBS secondary to mucosal damage. […] Intestinal failure secondary to CRE has a worse prognosis (approximately 70% survival rate at 5 years) compared with other causes of SBS. […] Various studies have reported that between 3% and 14% of patients requiring home PN do so because of CRE.

• #21 Radiation enteritis | Canadian Cancer Society

  https://cancer.ca/en/treatments/side-effects/radiation-enteritis

  Radiation enteritis is damage to the lining of the small and large intestines caused by radiation therapy to the abdomen, rectum or pelvis. It can happen during, shortly after or a long time after radiation therapy. […] Radiation enteritis is more likely to happen and symptoms can be worse when high doses of radiation are used or a large area of the intestines is treated with radiation. Chemotherapy given along with radiation therapy can also increase the risk of developing radiation enteritis.

• #22 Radiation Enteritis and Proctocolitis | Abdominal Key

  https://abdominalkey.com/radiation-enteritis-and-proctocolitis/

  Radiation was first used as a treatment modality for breast cancer in 1896, and a year later Dr. David Walsh, a physician at the Western Skin Hospital, London, described the first case of radiation enteritis. […] Today, radiation therapy is a common treatment for gynecologic, urologic, and rectal malignancies. Exclusion of innocent bowel from the radiation field during radiotherapy can be difficult, and when adjacent bowel gets in the way, radiation enteritis can result. The incidence of radiation enteritis and proctocolitis varies according to cancer type because treatment regimens vary between the different types of pelvic malignancies. […] The major risk factors for the development of radiation enteritis are the volume of bowel exposure to the radiation field and radiation dosage. Other risk factors include adhesions that prevent the bowel from being excluded from the field, radiation delivery techniques, and the use of radiosensitizing chemotherapeutic agents, such as fluorouracil and mitomycin.

• #23 Radiation Enteritis: Causes, Symptoms, Types, Risk Factors

  https://www.prepladder.com/neet-pg-study-material/radiology/radiation-enteritis-causes-symptoms-types-risk-factors-diagnosis-treatment-prevention-and-complications

  Radiation enteritis is the term for intestinal inflammation brought on by radiation therapy. […] For several weeks throughout therapy, frequent exposure to radioactive materials is typically required. Radiation causes tissue damage and causes healthy cells to become inflamed. The cells lining the intestines are more susceptible to the effects of radiation. […] The more doses you receive and the larger the colon treatment area, the greater your chance of developing radiation enteritis. […] Radiation enteritis can strike as many as 50% of individuals undergoing radiation therapy if the radiation is delivered to the belly or pelvis using old-fashioned techniques. […] Some people are more susceptible due to: Conditions such as high blood pressure and diabetes lower the quantity of blood that reaches their intestines.

• #24 Radiation Enteritis: Causes, Symptoms, Types, Risk Factors

  https://www.prepladder.com/neet-pg-study-material/radiology/radiation-enteritis-causes-symptoms-types-risk-factors-diagnosis-treatment-prevention-and-complications

  Tissue inflammation brought on by illnesses such as pelvic inflammatory disease already exists. […] Other treatments, such as chemotherapy, cause cell death. […] Inadequate food intake. […] Both the use of tobacco products and smoking. […] Damage to tissue from previous abdominal procedures.

• #25 Radiation Enteritis – DoveMed

  https://www.dovemed.com/diseases-conditions/radiation-enteritis

  Radiation therapy is commonly used to treat cancer and it employs the use of high-energy particles or waves, such as x-rays, gamma rays, electron or proton beams, to destroy cancer cells by damaging their DNA. […] Intestinal lining cells, which are very sensitive to radiation treatment, are damaged and slough off during treatment. The exact cause of how radiation affects the intestines, which leads to Radiation Enteritis is being researched into currently. […] Individuals with the following cancers receiving radiation therapy may be affected by Radiation Enteritis: Cervical cancer, Pancreatic cancer, Prostate cancer, Uterine cancer, Colon and rectal cancer.

• #26 What Should You Know About Radiation Enteritis? Symptoms and Causes

  https://www.webmd.com/cancer/what-is-radiation-enteritis

  Radiation enteritis is a condition described by inflammation in the small intestine. It results from radiation therapy to the rectum, abdomen, or pelvis. […] Radiation enteritis is among these risks. It could last for months or a few weeks. Up to 55% of people get the chronic form of this condition after radiation treatment. […] Continuous radiation triggers an immune response that leads to inflammation in the intestines and to radiation enteritis. […] There is some evidence that shows that radiation enteritis is more common in people who get radiation therapy for gynecological or gastrointestinal tumors as compared to urological tumors.

• #27

  https://journals.lww.com/co-gastroenterology/fulltext/2020/05000/radiation_enteritis__from_diagnosis_to_management.11.aspx

  Radiation enteritis appears to be more prevalent than originally thought because of patient underreporting and a lack of clinician awareness. […] Patient-related and treatment-related risk factors have now been identified and should be modified where possible. […] Medical and surgical factors have been explored, but manipulation of the gut microbiota offers one of the most exciting recent developments in disease prevention. […] Radiation enteritis is an important clinical problem, but awareness is lacking amongst patients and physicians.

• #28 Gastrointestinal Complications (PDQ®) – NCI

  https://www.cancer.gov/about-cancer/treatment/side-effects/constipation/gi-complications-hp-pdq

  Radiation enteritis is a functional disorder of the large and small bowel that occurs during or after a course of radiation therapy to the abdomen, pelvis, or rectum. […] Almost all patients undergoing radiation to the abdomen, pelvis, or rectum will show signs of acute enteritis. […] The large and small bowel are sensitive to ionizing radiation. […] Factors that influence the occurrence and severity of radiation enteritis include the following: Dose and fractionation of radiation, modality of radiation, tumor size and extent, volume of normal bowel treated, concomitant chemotherapy, and individual patient variables (e.g., previous abdominal or pelvic surgery, hypertension, diabetes mellitus, smoking, inadequate nutrition). […] Acute enteritis occurs during or within 3 months after irradiation, with the greatest prevalence during the fourth and fifth weeks.

• #29 Enteritis and cancer | EBSCO Research Starters

  https://www.ebsco.com/research-starters/health-and-medicine/enteritis-and-cancer

  There is controversy over how many people develop radiation enteritis. […] Some studies have found that almost all patients exposed to abdominal radiation develop some acute symptoms, while other studies have recorded rates of about 50 percent. […] This variation is probably due to different techniques and doses used at different cancer centers. […] Radiation is used to kill rapidly dividing cancer cells. However, it also kills normal cells, especially those that divide frequently. […] The cells lining both the large and small intestine tend to divide often and can be substantially damaged by exposure to radiation necessary to treat cancer occurring in the abdomen and pelvis. […] In chronic radiation enteritis, the cells lining the intestinal wall are permanently damaged, and symptoms continue indefinitely, although treatment may help to control them.

• #30 Pelvic Radiation Disease – Guts UK

  https://gutscharity.org.uk/advice-and-information/conditions/pelvic-radiation-disease/

  The effect of radiotherapy on the pelvic area can be acute (immediate) or chronic (long term). Between 6-8 in 10 people undergoing radiotherapy will experience acute side effects. These generally start 2 weeks into radiotherapy but can often settle between 2 to 6 months after the treatment is given. Symptoms which last longer than six months or develop afterwards, are described as chronic. 9 in 10 people reported chronic side-effects ranging from mild to severe in nature. 1 in 2 people had significant changes to their bowel function. […] Further research into the underlying mechanisms that cause pelvic radiation disease could lead to discovery of a reversible factor. Treatment could then target the underlying changes, rather than just treatment of symptoms.

• #31 Quality evaluation of guidelines for the diagnosis and treatment of radiation enteritis | Radiation Oncology | Full Text

  https://ro-journal.biomedcentral.com/articles/10.1186/s13014-023-02204-9

  Radiation enteritis refers to the intestinal radiation damage caused by radiotherapy in patients with pelvic malignancies such as bladder cancer, cervical cancer, endometrial cancer, ovarian cancer, prostate cancer and rectal cancer. […] The number of new cases of malignant pelvic tumors in China in 2015 alone exceeded 500,000; more than 61% of patients with malignant pelvic tumors received pelvic radiation therapy, 75% of patients receiving pelvic radiation therapy developed acute radioactive rectal injury, and 520% developed chronic radioactive rectal injury. […] The existence of these conditions makes it particularly important to formulate high-quality guidelines for the diagnosis and treatment of radioactive enteritis. […] The treatment methods mentioned in different radiation enteritis guidelines vary widely. The main causes for this include radioactive enteritis studied by RCT experiments, the unknown treatment safety of various studies, the different evidence classification systems, irregular guideline rating systems, and the difficulty in diagnosing radioactive enteritis or misdiagnosing it as other inflammatory drug intestinal infectious diseases, which can delay treatment. […] The fact that most of the supporting evidence mentions safety uncertainty is also troubling. This reflects the lack of scientific investment in this disease and the need for more high-quality RCTs, which is a major obstacle to the development of high-quality guidelines.

• #32 Research progress and treatment of radiation enteritis and gut microbiota

  https://www.e-roj.org/journal/view.php?doi=10.3857/roj.2023.00346

  The decrease in the number of beneficial bacteria will promote the proliferation of opportunistic pathogens and promote the release of endotoxins, thus aggravating the intestinal inflammatory response, inducing damage to the intestinal mucosal barrier, and aggravating the disease of patients. […] In recent years, many basic and clinical studies at home and abroad have been conducted on the relationship between gut microbiota and radioactive intestinal injury caused by pelvic radiotherapy, and considerable conclusions have been drawn. […] Studies have confirmed that probiotics can be used in radiation enteritis, and the use of probiotic preparations such as Lactobacillus acidophilus, Bifidobacterium bifidum and Lactobacillus casei during pelvic radiotherapy resulted in a decrease in the average number of bowel movements and the incidence of diarrhea.

Zobacz więcej