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• #1 Vitamin B12 & folate anaemia | NHS inform

  https://www.nhsinform.scot/illnesses-and-conditions/nutritional/vitamin-b12-or-folate-deficiency-anaemia/

  Vitamin B12 or folate deficiency anaemia can cause a wide range of symptoms. These usually develop gradually but can worsen if the condition goes untreated. […] A deficiency in either of these vitamins can cause a wide range of problems, including: extreme tiredness, a lack of energy, pins and needles (paraesthesia), a sore and red tongue, mouth ulcers, muscle weakness, disturbed vision, psychological problems, which may include depression and confusion, problems with memory, understanding and judgement. […] It’s important for vitamin B12 or folate deficiency anaemia to be diagnosed and treated as soon as possible because, although many of the symptoms improve with treatment, some problems caused by the condition can be irreversible. […] Vitamin B12 or folate deficiency anaemia occurs when a lack of either of these vitamins affects the body’s ability to produce fully functioning red blood cells.

• #2 Vitamin Deficiency Anemia – Blood Disorders – Merck Manual Consumer Version

  https://www.merckmanuals.com/home/blood-disorders/anemia/vitamin-deficiency-anemia

  Vitamin deficiency anemia results from low or depleted levels of vitamin B12 or folate (folic acid). […] People may be weak, short of breath, and pale. […] Nerves may malfunction. […] Symptoms of anemia due to vitamin B12 deficiency or folate deficiency develop slowly and are similar to symptoms caused by other types of anemia, such as fatigue, weakness, and paleness. Vitamin B12 deficiency can also cause nerves to malfunction, causing tingling, loss of sensation, and weakness. Severe vitamin B12 deficiency may cause confusion. In older adults, anemia caused by vitamin B12 deficiency may be mistaken for dementia because of this symptom. […] Deficiency of vitamin B12 or folate deficiency most often develops due to a lack of these vitamins in the diet or an inability to absorb these vitamins from the digestive tract.

• #3 Vitamin deficiency anemia // Middlesex Health

  https://middlesexhealth.org/learning-center/diseases-and-conditions/vitamin-deficiency-anemia

  Vitamin deficiency anemia usually develops slowly over several months to years. Signs and symptoms may be subtle at first but usually increase as the deficiency worsens. These may include: […] Symptoms can include fatigue, shortness of breath and dizziness.

• #4 Vitamin Deficiency Anemia: Symptoms & Causes

  https://my.clevelandclinic.org/health/diseases/17732-vitamin-deficiency-anemia

  Vitamin deficiency anemia is a condition that develops when you have low levels of vitamin B12 or B9 (folate). In this type of anemia, your body doesnt produce enough healthy red blood cells. […] Vitamin deficiency anemia symptoms may be mild or subtle. You may notice them gradually worsen over several months or years. You may experience: Dizziness. Fatigue. Heart palpitations. Muscle weakness. Numbness or tingling in your hands or feet. Pale or yellowish skin. Shortness of breath (dyspnea). Unexplained weight loss. […] Vitamin deficiency can also cause depression, and in severe cases, vitamin B12 deficiency may cause confusion, forgetfulness or even personality changes. In older people, this can sometimes be mistaken for dementia. […] Most people dont have long-term complications from vitamin deficiency anemia. With treatment, the condition often goes away. […] But its important to get treatment for vitamin deficiency anemia. Without treatment, vitamin deficiency anemia could lead to: Difficulty getting pregnant. Heart problems, including heart failure. Nerve problems. Pregnancy complications.

• #5 Vitamin deficiency anemia | UM Health-Sparrow

  https://www.uofmhealthsparrow.org/departments-conditions/conditions/vitamin-deficiency-anemia

  Vitamin deficiency anemia usually develops slowly over several months to years. Signs and symptoms may be subtle at first but usually increase as the deficiency worsens. These may include: […] Symptoms can include fatigue, shortness of breath and dizziness. […] A lack of folate can cause birth defects during pregnancy. However, folate deficiency is less common now in countries that routinely add folate to food products such as breads, cereals and pasta. […] Being deficient in vitamin B-12 or folate increases your risk of many health problems, including: […] Untreated, vitamin B-12 deficiency can lead to neurological problems, such as persistent tingling in the hands and feet or problems with balance. It can lead to mental confusion and forgetfulness because vitamin B-12 is necessary for healthy brain function.

• #6

  https://www.nhs.uk/conditions/vitamin-b12-or-folate-deficiency-anaemia/symptoms/

  Vitamin B12 or folate deficiency anaemia can cause a wide range of symptoms. These usually develop gradually, but can worsen if the condition goes untreated. […] Symptoms of vitamin B12 and folate deficiency anaemia include: rapid breathing or shortness of breath, headaches, indigestion, loss of appetite, palpitations, problems with your vision, feeling weak or tired, diarrhoea, a sore or red tongue, sometimes with mouth ulcers, problems with memory, understanding and judgment (cognitive changes). […] Vitamin B12 deficiency can also cause symptoms that affect your brain and nervous system (neurological symptoms), including: numbness, muscle weakness, psychological problems, which can range from mild depression or anxiety, to confusion and dementia, problems with balance and coordination, pins and needles, incontinence.

• #7 Vitamin B12 & folate anaemia | NHS inform

  https://www.nhsinform.scot/illnesses-and-conditions/nutritional/vitamin-b12-or-folate-deficiency-anaemia/

  Vitamin B12 or folate deficiency anaemia can cause a wide range of symptoms. These usually develop gradually but can worsen if the condition goes untreated. […] A deficiency in either of these vitamins can cause a wide range of problems, including: extreme tiredness, a lack of energy, pins and needles (paraesthesia), a sore and red tongue, mouth ulcers, muscle weakness, disturbed vision, psychological problems, which may include depression and confusion, problems with memory, understanding and judgement. […] It’s important for vitamin B12 or folate deficiency anaemia to be diagnosed and treated as soon as possible because, although many of the symptoms improve with treatment, some problems caused by the condition can be irreversible. […] Vitamin B12 or folate deficiency anaemia occurs when a lack of either of these vitamins affects the body’s ability to produce fully functioning red blood cells.

• #8 Vitamin Deficiency Anemia: Symptoms & Causes

  https://my.clevelandclinic.org/health/diseases/17732-vitamin-deficiency-anemia

  Vitamin deficiency anemia is a condition that develops when you have low levels of vitamin B12 or B9 (folate). In this type of anemia, your body doesnt produce enough healthy red blood cells. […] Vitamin deficiency anemia symptoms may be mild or subtle. You may notice them gradually worsen over several months or years. You may experience: Dizziness. Fatigue. Heart palpitations. Muscle weakness. Numbness or tingling in your hands or feet. Pale or yellowish skin. Shortness of breath (dyspnea). Unexplained weight loss. […] Vitamin deficiency can also cause depression, and in severe cases, vitamin B12 deficiency may cause confusion, forgetfulness or even personality changes. In older people, this can sometimes be mistaken for dementia. […] Most people dont have long-term complications from vitamin deficiency anemia. With treatment, the condition often goes away. […] But its important to get treatment for vitamin deficiency anemia. Without treatment, vitamin deficiency anemia could lead to: Difficulty getting pregnant. Heart problems, including heart failure. Nerve problems. Pregnancy complications.

• #9 Anemia – Vitamin B12–Deficiency Anemia | NHLBI, NIH

  https://www.nhlbi.nih.gov/health/anemia/vitamin-b12-deficiency-anemia

  Vitamin B12deficiency anemia, also known as cobalamin deficiency, is a condition that develops when your body can’t make enough healthy red blood cells because it doesn’t have enough vitamin B12. Your body needs vitamin B12 to make healthy red blood cells, white blood cells, and platelets. Since your body doesnt make vitamin B12, you have to get it from the foods you eat or from supplements. […] If you have vitamin B12deficiency anemia, you may have the typical symptoms of anemia at first, such as fatigue, paleness, shortness of breath, headaches, or dizziness. If left untreated, you may start to notice brain and nervous system symptoms. This is because vitamin B12 is also needed for your brain and your nerves to work properly. […] Your symptoms may include: Tingling feelings or pain, Trouble walking, Uncontrollable muscle movements, Confusion, slower thinking, forgetfulness, and memory loss, Mood or mental changes, such as depression or irritability, Problems with smell or taste, Vision problems, Diarrhea and weight loss, Glossitis, which is a painful, smooth, red tongue.

• #10 Pernicious Anemia: Definition, Symptoms, Causes & Treatment

  https://my.clevelandclinic.org/health/diseases/22377-pernicious-anemia

  Yes. Normally, your body stores vitamin B12 that it gets from what you eat. Your body stores vitamin B12, slowly using it over time. It can take three to five years for your body to use up your vitamin B12 reserves. After that, it can be several more years before you develop pernicious anemia symptoms. […] Most people begin feeling better shortly after starting treatment. Pernicious anemia can’t be cured, but increasing your vitamin B12 intake may eliminate most symptoms. The neurologic complications of pernicious anemia, however, can persist even after B12 stores are fully replaced. […] If you have pernicious anemia, you’ll need to take vitamin B12 supplements regularly for the rest of your life. Other causes of B12 deficiency may be helped by increasing the vitamin B12 in your diet. […] Pernicious anemia symptoms can take years to surface. You may be surprised to learn you have a condition that can cause serious medical problems.

• #11 Vitamin B12 Deficiency Anemia: Symptoms, Causes, Treatments

  https://www.webmd.com/a-to-z-guides/vitamin-b12-deficiency-anemia

  You feel dizzy. […] You have no appetite. […] You’ve lost weight without trying. […] Your heart beats too fast or you have chest pain. […] Your muscles feel weak. […] Your hands and feet feel like they’re numb or tingling. […] You have vision problems. […] You feel confused or forgetful. […] You have difficulty walking or speaking as you used to. […] Neurological problems from B12 deficiency may be permanent. […] The main difference in the two conditions is pernicious anemia is due to your body not being able to absorb B12, while other types of B12 anemia may be due to your not having enough of the vitamin in your diet. But the symptoms are the same for both. […] It can take up to 5 years before you start to see symptoms of pernicious anemia. Often you’ll have the neurological or psychological symptoms before the anemia (low red blood cell count) is present. This means there’s a big chance of being misdiagnosed because many other conditions have these symptoms too.

• #12

  https://www.nhs.uk/conditions/vitamin-b12-or-folate-deficiency-anaemia/symptoms/

  Vitamin B12 or folate deficiency anaemia can cause a wide range of symptoms. These usually develop gradually, but can worsen if the condition goes untreated. […] Symptoms of vitamin B12 and folate deficiency anaemia include: rapid breathing or shortness of breath, headaches, indigestion, loss of appetite, palpitations, problems with your vision, feeling weak or tired, diarrhoea, a sore or red tongue, sometimes with mouth ulcers, problems with memory, understanding and judgment (cognitive changes). […] Vitamin B12 deficiency can also cause symptoms that affect your brain and nervous system (neurological symptoms), including: numbness, muscle weakness, psychological problems, which can range from mild depression or anxiety, to confusion and dementia, problems with balance and coordination, pins and needles, incontinence.

• #13 11 symptoms of vitamin B12 deficiency

  https://www.medicalnewstoday.com/articles/324265

  Tingling hands or feet […] Vitamin B12 deficiency may cause pins and needles in the hands or feet. This symptom occurs because the vitamin plays a crucial role in the nervous system. Its absence can cause people to develop nerve conduction problems or nerve damage. […] Trouble walking […] Over time, peripheral nerve damage can lead to movement problems. Numbness in the feet and limbs may make it hard for a person to walk without support. They may also experience muscle weakness and diminished reflexes. […] Pale skin […] A vitamin B12 deficiency can lead to pale skin and yellowing of the skin, called jaundice. These changes in skin color can develop when a persons body is unable to produce enough RBCs. […] Fatigue […] Megaloblastic anemia due to vitamin B12 deficiency may lead to a person feeling fatigued. Without enough RBCs to carry oxygen around their body, a person can feel extremely tired.

• #14 Vitamin B12 Deficiency – StatPearls – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK441923/

  Vitamin B12 deficiency can lead to hematologic and neurological symptoms. […] B12 deficiency can manifest as macrocytic anemia, and thus, the presenting symptoms often include signs of anemia, such as fatigue and pallor. […] Other presenting complaints may include peripheral neuropathy, glossitis, diarrhea, headaches, and neuropsychiatric disturbances. […] In more severe cases, the disease process can progress to involve the nervous system. […] A thorough evaluation of vitamin B12 deficiency should include a complete history and physical with an increased emphasis on gastrointestinal (GI) and neurologic findings. […] For patients who are promptly treated with vitamin B12, the neurological symptoms of subacute combined degeneration partially resolve, and the progression may stop. […] The best response is obtained in people with the absence of severe neurological deficits.

• #15 Anemia – Vitamin B12–Deficiency Anemia | NHLBI, NIH

  https://www.nhlbi.nih.gov/health/anemia/vitamin-b12-deficiency-anemia

  Vitamin B12deficiency anemia, also known as cobalamin deficiency, is a condition that develops when your body can’t make enough healthy red blood cells because it doesn’t have enough vitamin B12. Your body needs vitamin B12 to make healthy red blood cells, white blood cells, and platelets. Since your body doesnt make vitamin B12, you have to get it from the foods you eat or from supplements. […] If you have vitamin B12deficiency anemia, you may have the typical symptoms of anemia at first, such as fatigue, paleness, shortness of breath, headaches, or dizziness. If left untreated, you may start to notice brain and nervous system symptoms. This is because vitamin B12 is also needed for your brain and your nerves to work properly. […] Your symptoms may include: Tingling feelings or pain, Trouble walking, Uncontrollable muscle movements, Confusion, slower thinking, forgetfulness, and memory loss, Mood or mental changes, such as depression or irritability, Problems with smell or taste, Vision problems, Diarrhea and weight loss, Glossitis, which is a painful, smooth, red tongue.

• #16 11 symptoms of vitamin B12 deficiency

  https://www.medicalnewstoday.com/articles/324265

  Tingling hands or feet […] Vitamin B12 deficiency may cause pins and needles in the hands or feet. This symptom occurs because the vitamin plays a crucial role in the nervous system. Its absence can cause people to develop nerve conduction problems or nerve damage. […] Trouble walking […] Over time, peripheral nerve damage can lead to movement problems. Numbness in the feet and limbs may make it hard for a person to walk without support. They may also experience muscle weakness and diminished reflexes. […] Pale skin […] A vitamin B12 deficiency can lead to pale skin and yellowing of the skin, called jaundice. These changes in skin color can develop when a persons body is unable to produce enough RBCs. […] Fatigue […] Megaloblastic anemia due to vitamin B12 deficiency may lead to a person feeling fatigued. Without enough RBCs to carry oxygen around their body, a person can feel extremely tired.

• #17 Vitamin B12 deficiency – Wikipedia

  https://en.wikipedia.org/wiki/Vitamin_B12_deficiency

  Vitamin B12 deficiency appears slowly and worsens over time, and can often be confused with other conditions. […] Vitamin B12 deficiency can lead to anemia, neurologic, and digestive dysfunctions. […] A mild deficiency may not cause any discernible symptoms, but at levels moderately lower than normal, a range of symptoms such as feeling tired, weak, lightheadedness, headaches, dizziness, rapid breathing, rapid heartbeat, cold hands and feet, low-grade fevers, tremor, cold intolerance, easy bruising and bleeding, pale skin, low blood pressure, sore tongue, upset stomach, loss of appetite, weight loss, constipation, diarrhea, severe joint pain, feeling abnormal sensations including numbness or tingling (pins and needles) to the fingers and toes, and tinnitus, may be experienced. […] Severe vitamin B12 deficiency can damage nerve cells.

• #18 Vitamin B12 Deficiency – Nutritional Disorders – Merck Manual Professional Edition

  https://www.merckmanuals.com/professional/nutritional-disorders/vitamin-deficiency-dependency-and-toxicity/vitamin-b12-deficiency

  Anemia usually develops insidiously. It is often more severe than its symptoms indicate because its slow evolution allows physiologic adaptation. […] Neurologic symptoms develop independently from and often without hematologic abnormalities. […] Subacute combined degeneration refers to degenerative changes in the nervous system due to vitamin B12 deficiency; they affect mostly brain and spinal cord white matter. Demyelinating or axonal peripheral neuropathies can occur. […] In early stages, decreased position and vibratory sensation in the extremities is accompanied by mild to moderate weakness and hyporeflexia. In later stages, spasticity, extensor plantar responses, greater loss of position and vibratory sensation in the lower extremities, and ataxia emerge. […] Some patients are also irritable and mildly depressed. Paranoia (megaloblastic madness), delirium, confusion, and, at times, postural hypotension may occur in advanced cases. The confusion may be difficult to differentiate from age-related dementias, such as Alzheimer disease.

• #19 Vitamin Deficiency Anemia: Symptoms & Causes

  https://my.clevelandclinic.org/health/diseases/17732-vitamin-deficiency-anemia

  Vitamin deficiency anemia is a condition that develops when you have low levels of vitamin B12 or B9 (folate). In this type of anemia, your body doesnt produce enough healthy red blood cells. […] Vitamin deficiency anemia symptoms may be mild or subtle. You may notice them gradually worsen over several months or years. You may experience: Dizziness. Fatigue. Heart palpitations. Muscle weakness. Numbness or tingling in your hands or feet. Pale or yellowish skin. Shortness of breath (dyspnea). Unexplained weight loss. […] Vitamin deficiency can also cause depression, and in severe cases, vitamin B12 deficiency may cause confusion, forgetfulness or even personality changes. In older people, this can sometimes be mistaken for dementia. […] Most people dont have long-term complications from vitamin deficiency anemia. With treatment, the condition often goes away. […] But its important to get treatment for vitamin deficiency anemia. Without treatment, vitamin deficiency anemia could lead to: Difficulty getting pregnant. Heart problems, including heart failure. Nerve problems. Pregnancy complications.

• #20 Pernicious Anemia: Definition, Symptoms, Causes & Treatment

  https://my.clevelandclinic.org/health/diseases/22377-pernicious-anemia

  Pernicious anemia, one of the causes of vitamin B12 deficiency, is an autoimmune condition that prevents your body from absorbing vitamin B12. Left untreated, pernicious anemia can cause serious medical issues, including irreversible damage to your nervous system. […] You can have pernicious anemia for several years before noticing changes in your body. Left untreated, pernicious anemia can cause serious medical issues, including irreversible damage to your nervous system. […] Generally speaking, the longer you go without adequate vitamin B12, the more serious your symptoms are. Early on, people may have mild symptoms they may think are caused by other common conditions. […] Long-term low vitamin B12 levels caused by pernicious anemia can affect your nervous system. Symptoms of potential nervous system problems include: confusion, short-term memory loss, depression, loss of balance, numbness and tingling in your hands and feet, problems concentrating, irritability, hallucinations, delusions, optic nerve degeneration that affects your eyesight.

• #21 Vitamin B12 deficiency – Wikipedia

  https://en.wikipedia.org/wiki/Vitamin_B12_deficiency

  If this happens, vitamin B12 deficiency may result in sense loss, loss of sensation in the feet, difficulty walking, poor balance, blurred vision, changes in reflexes, muscle weakness, decreased smell and taste, decreased level of consciousness, mood changes, memory loss, depression, irritability, anxiety, clumsiness, disorientation, psychosis and, in severe cases, dementia. […] A further complication of severe deficiency is the neurological complex known as subacute combined degeneration of spinal cord. […] The presence of peripheral sensory-motor symptoms or subacute combined degeneration of spinal cord strongly suggests the presence of a B12 deficiency instead of folate deficiency. […] Dementia and depression have been associated with this deficiency as well, possibly from the under-production of methionine because of the inability to convert homocysteine into this product.

• #22 Severe megaloblastic anemia: Vitamin deficiency and other causes | Cleveland Clinic Journal of Medicine

  https://www.ccjm.org/content/87/3/153

  Vitamin B12 deficiency can cause subacute combined degeneration of the dorsal and lateral columns of the spinal cord. Patients may experience bilateral and symmetrical paresthesia and decreased vibratory and positional sense. Psychiatric manifestations include memory loss, delirium, dementia, depression, mania, and hallucinations. […] An increased risk of thrombosis is seen in vitamin B12 and folate deficiency, possibly as a consequence of hyperhomocysteinemia. […] Atrophic glossitis (swollen, erythematous, smooth tongue) is a common, albeit nonspecific, finding in vitamin B12 deficiency.

• #23 Vitamin B12 deficiency can be sneaky and harmful – Harvard Health

  https://www.health.harvard.edu/blog/vitamin-b12-deficiency-can-be-sneaky-harmful-201301105780

  What harm can having too little of vitamin B12 do? Consider this: Over the course of two months, a 62-year-old man developed numbness and a „pins and needles” sensation in his hands, had trouble walking, experienced severe joint pain, began turning yellow, and became progressively short of breath. […] A severe vitamin B12 deficiency can lead to deep depression, paranoia and delusions, memory loss, incontinence, loss of taste and smell, and more. […] Vitamin B12 deficiency can be slow to develop, causing symptoms to appear gradually and intensify over time. It can also come on relatively quickly. Given the array of symptoms a vitamin B12 deficiency can cause, the condition can be overlooked or confused with something else. Vitamin B12 deficiency symptoms may include: strange sensations, numbness, or tingling in the hands, legs, or feet […] difficulty walking (staggering, balance problems) […] anemia […] a swollen, inflamed tongue […] difficulty thinking and reasoning (cognitive difficulties), or memory loss […] weakness […] fatigue. […] Early detection and treatment is important. If left untreated, the deficiency can cause severe neurologic problems and blood diseases.

• #24 Vitamin Deficiency Anemia – Blood Disorders – Merck Manual Consumer Version

  https://www.merckmanuals.com/home/blood-disorders/anemia/vitamin-deficiency-anemia

  Vitamin deficiency anemia results from low or depleted levels of vitamin B12 or folate (folic acid). […] People may be weak, short of breath, and pale. […] Nerves may malfunction. […] Symptoms of anemia due to vitamin B12 deficiency or folate deficiency develop slowly and are similar to symptoms caused by other types of anemia, such as fatigue, weakness, and paleness. Vitamin B12 deficiency can also cause nerves to malfunction, causing tingling, loss of sensation, and weakness. Severe vitamin B12 deficiency may cause confusion. In older adults, anemia caused by vitamin B12 deficiency may be mistaken for dementia because of this symptom. […] Deficiency of vitamin B12 or folate deficiency most often develops due to a lack of these vitamins in the diet or an inability to absorb these vitamins from the digestive tract.

• #25 Vitamin B12 Deficiency Anemia: Symptoms, Causes, Treatments

  https://www.webmd.com/a-to-z-guides/vitamin-b12-deficiency-anemia

  You feel dizzy. […] You have no appetite. […] You’ve lost weight without trying. […] Your heart beats too fast or you have chest pain. […] Your muscles feel weak. […] Your hands and feet feel like they’re numb or tingling. […] You have vision problems. […] You feel confused or forgetful. […] You have difficulty walking or speaking as you used to. […] Neurological problems from B12 deficiency may be permanent. […] The main difference in the two conditions is pernicious anemia is due to your body not being able to absorb B12, while other types of B12 anemia may be due to your not having enough of the vitamin in your diet. But the symptoms are the same for both. […] It can take up to 5 years before you start to see symptoms of pernicious anemia. Often you’ll have the neurological or psychological symptoms before the anemia (low red blood cell count) is present. This means there’s a big chance of being misdiagnosed because many other conditions have these symptoms too.

• #26

  https://www.nhs.uk/conditions/vitamin-b12-or-folate-deficiency-anaemia/symptoms/

  It’s important for vitamin B12 or folate deficiency anaemia to be diagnosed and treated as soon as possible. […] Although many of the symptoms improve with treatment, some problems caused by the condition can be irreversible if left untreated. […] The longer the condition goes untreated, the higher the chance of permanent damage.

• #27 Vitamin B12 Deficiency: Symptoms, Treatment and More

  https://www.verywellhealth.com/vitamin-b12-deficiency-2488570

  Vitamin B12 deficiency can cause fatigue, muscle weakness, and memory problems. […] A vitamin B12 deficiency can cause headaches, fatigue, muscle weakness, and depression. […] Symptoms of vitamin B12 deficiency include fatigue, dizziness, paleness, and a rapid heart rate. […] Vitamin B12 deficiency leads to defective RBCs. This causes anemia. Anemia can make you feel weak and fatigued. […] Vitamin B12 deficiency may cause dementia. These symptoms may include memory loss, cognitive decline, behavioral changes, and problems with self-care. […] Symptoms of vitamin B12 deficiency typically develop gradually over the course of weeks or months. They do not usually improve without treatment. […] Recovery from vitamin B12 deficiency takes time. You may not have any improvement during the first few months of treatment. Improvement may be gradual and may continue for up to six to 12 months. […] If you have a vitamin B12 deficiency, you may have symptoms of anemia, problems with your nerves, sensory issues, or even dementia.

• #28 Vitamin B12 Deficiency: Causes, Symptoms, and Treatment

  https://www.webmd.com/diet/vitamin-b12-deficiency-symptoms-causes

  Vitamin B12 deficiency symptoms: […] – Weakness, tiredness, or lightheadedness […] – Heart palpitations and shortness of breath […] – Pale skin […] – A painful, smooth, inflamed tongue (glossitis) […] – Digestive issues […] – Bluish or gray-brown nails […] – Loss of appetite […] What happens if your vitamin B12 deficiency is left untreated? […] If you don’t treat your B12 deficiency, it can lead to more severe neurological problems, including: […] – Problems walking or speaking […] – Vision loss […] – Numbness or tingling […] – Muscle weakness […] – Difficulty remembering things […] – Depression or mood swings […] The stages of B12 deficiency are: […] Stage I. Low serum level. You have low levels of vitamin B12 in your blood. You have no B12 deficiency symptoms.

• #29 Vitamin B12 Deficiency: Causes, Symptoms, and Treatment

  https://www.webmd.com/diet/vitamin-b12-deficiency-symptoms-causes

  Stage II. Low cell store. You have low levels of B12 in your cells. […] Stage III. Biochemical deficiency. You have higher levels of the chemicals homocysteine and methylmalonic acid and reduced DNA synthesis, leading to neurological and psychological symptoms, such as confusion, mood swings, problems walking or talking, and irritability. […] Stage IV. Clinically evident deficiency. You get macrocytic anemia or very large red blood cells, which don’t work properly. You usually feel tired and weak. You also have the neurological and psychological symptoms of stage III.

• #30 Vitamin B12 deficiency – Wikipedia

  https://en.wikipedia.org/wiki/Vitamin_B12_deficiency

  If this happens, vitamin B12 deficiency may result in sense loss, loss of sensation in the feet, difficulty walking, poor balance, blurred vision, changes in reflexes, muscle weakness, decreased smell and taste, decreased level of consciousness, mood changes, memory loss, depression, irritability, anxiety, clumsiness, disorientation, psychosis and, in severe cases, dementia. […] A further complication of severe deficiency is the neurological complex known as subacute combined degeneration of spinal cord. […] The presence of peripheral sensory-motor symptoms or subacute combined degeneration of spinal cord strongly suggests the presence of a B12 deficiency instead of folate deficiency. […] Dementia and depression have been associated with this deficiency as well, possibly from the under-production of methionine because of the inability to convert homocysteine into this product.

• #31 Vitamin B12 deficiency – Wikipedia

  https://en.wikipedia.org/wiki/Vitamin_B12_deficiency

  Each of those symptoms can occur either alone or with others. […] Severe vitamin B12 deficiency is associated with subacute combined degeneration of the spinal cord, which involves demyelination of the posterior and lateral columns of the spinal cord. […] Symptoms include memory and cognitive impairment, sensory loss, motor disturbances, personality changes, disorientation, irritability, dementia, loss of posterior column functions and disturbances in proprioception. […] In advanced stages of vitamin B12 deficiency, cases of psychosis, paranoia and severe depression have been observed, which may lead to permanent disability if left untreated. […] Studies have shown the rapid reversal of the neurological symptoms of vitamin B12 deficiency, after treatment with high-dose of vitamin B12 supplementation; suggesting the importance of prompt treatment in reversing neurological manifestations.

• #32 Symptoms of Vitamin B Deficiency

  https://www.healthline.com/health/symptoms-of-vitamin-b-deficiency

  Symptoms of vitamin B deficiency may vary depending on which B vitamin you’re deficient in. You may experience fatigue, skin rash, or confusion. […] Symptoms of vitamin B12 deficiency may include: fatigue, weakness, loss of appetite, headache, skin paleness, heart palpitations, weight loss, mouth ulcers, numbness and tingling in the hands and feet (peripheral neuropathy), shortness of breath, vision problems, irritability. […] Vitamin B12 deficiency is also associated with cognitive changes, such as dementia, paranoia, and depression. […] Vitamin B6 deficiency is not common in the United States, but symptoms may include: nausea, itchy rash or cracks around the mouth (cheilosis), skin rashes or dermatitis, anemia, susceptibility to infections, irritability, depression, confusion. […] Low levels of vitamin B9 can result in the following symptoms: megaloblastic anemia, which causes weakness, fatigue, trouble concentrating, irritability, headache, heart palpitations, shortness of breath, open sores in the mouth, changes in skin, hair, or fingernail color.

• #33 Symptoms of Vitamin B Deficiency

  https://www.healthline.com/health/symptoms-of-vitamin-b-deficiency

  Symptoms common to all vitamin B deficiencies may include fatigue, nausea, muscle weakness, and skin changes. Vitamin B12 and B9 deficiencies may lead to anemia since they’re essential in red blood cell production. […] Vitamin B12 deficiency may cause tiredness, headaches, irritability, heart palpitations, shortness of breath, and numbness, tingling, and weakness.

• #34 Vitamin Deficiency Anemia: Symptoms & Causes

  https://my.clevelandclinic.org/health/diseases/17732-vitamin-deficiency-anemia

  Vitamin deficiency anemia is a condition that develops when you have low levels of vitamin B12 or B9 (folate). In this type of anemia, your body doesnt produce enough healthy red blood cells. […] Vitamin deficiency anemia symptoms may be mild or subtle. You may notice them gradually worsen over several months or years. You may experience: Dizziness. Fatigue. Heart palpitations. Muscle weakness. Numbness or tingling in your hands or feet. Pale or yellowish skin. Shortness of breath (dyspnea). Unexplained weight loss. […] Vitamin deficiency can also cause depression, and in severe cases, vitamin B12 deficiency may cause confusion, forgetfulness or even personality changes. In older people, this can sometimes be mistaken for dementia. […] Most people dont have long-term complications from vitamin deficiency anemia. With treatment, the condition often goes away. […] But its important to get treatment for vitamin deficiency anemia. Without treatment, vitamin deficiency anemia could lead to: Difficulty getting pregnant. Heart problems, including heart failure. Nerve problems. Pregnancy complications.

• #35

  https://www.nhs.uk/conditions/vitamin-b12-or-folate-deficiency-anaemia/symptoms/

  It’s important for vitamin B12 or folate deficiency anaemia to be diagnosed and treated as soon as possible. […] Although many of the symptoms improve with treatment, some problems caused by the condition can be irreversible if left untreated. […] The longer the condition goes untreated, the higher the chance of permanent damage.

• #36 Vitamin B12 & folate anaemia | NHS inform

  https://www.nhsinform.scot/illnesses-and-conditions/nutritional/vitamin-b12-or-folate-deficiency-anaemia/

  Most people with vitamin B12 or folate deficiency anaemia have underdeveloped red blood cells that are larger than normal. The medical term for this is megaloblastic anaemia. […] Vitamin B12 deficiency anaemia is usually treated with injections of vitamin B12, in a form called hydroxocobalamin. […] Most cases of vitamin B12 and folate deficiency can be easily treated with injections or tablets to replace the missing vitamins. […] Adults with severe anaemia are at risk of developing heart failure. […] A lack of vitamin B12 can cause neurological problems (issues affecting your nervous system), such as vision problems, memory loss, pins and needles (paraesthesia), loss of physical coordination (ataxia), which can affect your whole body and cause difficulty speaking or walking, damage to parts of the nervous system (peripheral neuropathy), particularly in the legs. […] If neurological problems do develop, they may be irreversible.

• #37

  https://www.nhs.uk/conditions/vitamin-b12-or-folate-deficiency-anaemia/complications/

  A lack of vitamin B12 (with or without anaemia) can cause complications. […] A lack of folate (with or without anaemia) can also cause complications. […] Vitamin B12 deficiency can sometimes lead to temporary infertility, an inability to conceive. […] As with a lack of vitamin B12, a folate deficiency can also affect your fertility. […] Research has shown a lack of folate in your body may increase your risk of cardiovascular disease (CVD). […] Research has shown that folate deficiency can increase your risk of some cancers, such as colon cancer. […] A lack of folate during pregnancy may increase the risk of the baby being born prematurely (before the 37th week of pregnancy) or having a low birth weight. […] As with a vitamin B12 deficiency, a lack of folate can also affect an unborn baby’s growth and development in the womb (uterus).

• #38 Anemia – Vitamin B12–Deficiency Anemia | NHLBI, NIH

  https://www.nhlbi.nih.gov/health/anemia/vitamin-b12-deficiency-anemia

  If your doctor diagnoses you with vitamin B12deficiency anemia, your treatment will depend on the cause and seriousness of your condition. Some people need lifelong treatment. […] Some symptoms may take months to improve, depending on how serious they are. Some symptoms related to the brain or the nerves, such as numbness and tingling, may not go away even with treatment. […] Vitamin B12deficiency may cause serious complications, such as bleeding, infections, and problems with your brain or nerves that may be permanent. Babies born to mothers who have vitamin B12deficiency may have developmental delays and birth defects of the brain and spinal cord.

• #39 Iron deficiency anaemia | NHS inform

  https://www.nhsinform.scot/illnesses-and-conditions/nutritional/iron-deficiency-anaemia/

  Research has shown iron deficiency anaemia can affect your immune system the body’s natural defence system. This increases your vulnerability to infection. […] Adults with severe anaemia may be at risk of developing complications that affect their heart or lungs. […] Pregnant women with severe anaemia have an increased risk of developing complications, particularly during and after birth.

• #40 Signs, Symptoms, and Complications of Pernicious Anemia | Hematology-Oncology Associates of CNY

  https://www.hoacny.com/patient-resources/blood-disorders/what-pernicious-anemia/signs-symptoms-and-complications-pernicious

  A smooth, thick, red tongue also is a sign of vitamin B12 deficiency and pernicious anemia. […] Infants who have vitamin B12 deficiency may have poor reflexes or unusual movements, such as face tremors. They may have trouble feeding due to tongue and throat problems. They also may be irritable. If vitamin B12 deficiency isn’t treated, these infants may have permanent growth problems.

• #41 Vitamin B12 Deficiency: Signs, Causes and Treatments | Ada

  https://ada.com/conditions/vitamin-b12-deficiency/

  The symptoms of vitamin B12 deficiency can develop slowly and worsen over time. Some symptoms may be experienced by people who have a vitamin B12 deficiency without anemia. Some people may experience no symptoms, despite low levels of vitamin B12. […] In babies, signs of vitamin B12 deficiency may include failure to thrive, movement difficulties, delays in reaching developmental milestones, and anemia. […] A vitamin B12 deficiency can cause a wide range of symptoms, including psychiatric symptoms like irritability, psychosis, and depression.

• #42 Iron and iron deficiency | Better Health Channel

  https://www.betterhealth.vic.gov.au/health/conditionsandtreatments/iron

  Most of your bodys iron is in the haemoglobin of your red blood cells, which carry oxygen to your body. Extra iron is stored in your liver and is used by your body when your dietary intake is too low. If you dont have enough iron in your diet, your bodys iron stores get lower over time. This can cause: […] Iron deficiency anaemia when your haemoglobin levels are so low that your blood is unable to deliver enough oxygen to your cells. Symptoms include looking very pale, breathlessness, dizziness and fatigue. People with iron deficiency anaemia may also have reduced immune function, so they are more vulnerable to infection. In children, iron deficiency anaemia can affect growth and brain development. […] The signs and symptoms of iron deficiency anaemia in children may include: behavioural problems, repeat infections, loss of appetite, lethargy, breathlessness, increased sweating, strange food cravings (pica) like eating dirt, failure to grow at the expected rate.

• #43 Pernicious anemia: MedlinePlus Medical EncyclopediaLock

  https://medlineplus.gov/ency/article/000569.htm

  Pernicious anemia is a decrease in red blood cells that occurs when the intestines cannot properly absorb vitamin B12. […] Symptoms may include: Diarrhea or constipation, Nausea, Vomiting, Fatigue, lack of energy, or lightheadedness when standing up or with exertion, Loss of appetite, Pale skin (mild jaundice), Shortness of breath, mostly during exercise, Heartburn, Swollen, red tongue or bleeding gums. […] If you have a low vitamin B12 level for a long time, you can have nervous system damage. Symptoms may include: Confusion, Short-term memory loss, Depression, Loss of balance, Numbness and tingling in the hands and feet, Problems concentrating, Irritability, Hallucinations, Delusions, Optic nerve atrophy. […] It is important to start treatment early. Nerve damage can be permanent if treatment does not start within 6 months of symptoms.

• #44 Vitamin B12 Deficiency Anemia: Symptoms and Risks – Consensus: AI Search Engine for Research

  https://consensus.app/home/blog/vitamin-b12-deficiency-anemia-symptoms-and-risks/

  Cognitive Decline: Older adults with vitamin B12 deficiency are at risk for cognitive decline and dementia. […] Depression and Psychosis: Some individuals may present with psychiatric symptoms such as depression and psychosis, which can complicate the diagnosis. […] Early detection and appropriate management of vitamin B12 deficiency are crucial to prevent irreversible damage. […] High-dose oral vitamin B12 (1 to 2 mg daily) is effective for correcting anemia and neurological symptoms. Intramuscular administration may be preferred for severe cases due to its rapid effect. […] Many patients, especially older adults and those with irreversible causes of deficiency, may require lifelong vitamin B12 supplementation.

• #45 Vitamin B12 Deficiency Anemia: Symptoms, Causes, Treatments

  https://www.webmd.com/a-to-z-guides/vitamin-b12-deficiency-anemia

  This type of anemia means that your body doesn’t have enough healthy red blood cells because you’re low in vitamin B12. These cells transport oxygen throughout your body. You need iron and vitamins — including B12 — to make red blood cells. […] When you don’t have enough red blood cells, your body doesnt get the oxygen it needs to work like it should. Anemia may make you feel tired, weak, and short of breath. […] Your body stores 1,000 to 2,000 times as much vitamin B12 as you eat in a day. So it can take 2-5 years before you see signs of B12 deficiency. Some people with the condition don’t have any symptoms, at least at first. Here are the most common signs of B12 deficiency: […] You feel tired and lack energy. […] Your skin looks pale or yellow. […] You have nausea, vomiting, or diarrhea.

• #46 Pernicious Anemia: Definition, Symptoms, Causes & Treatment

  https://my.clevelandclinic.org/health/diseases/22377-pernicious-anemia

  Yes. Normally, your body stores vitamin B12 that it gets from what you eat. Your body stores vitamin B12, slowly using it over time. It can take three to five years for your body to use up your vitamin B12 reserves. After that, it can be several more years before you develop pernicious anemia symptoms. […] Most people begin feeling better shortly after starting treatment. Pernicious anemia can’t be cured, but increasing your vitamin B12 intake may eliminate most symptoms. The neurologic complications of pernicious anemia, however, can persist even after B12 stores are fully replaced. […] If you have pernicious anemia, you’ll need to take vitamin B12 supplements regularly for the rest of your life. Other causes of B12 deficiency may be helped by increasing the vitamin B12 in your diet. […] Pernicious anemia symptoms can take years to surface. You may be surprised to learn you have a condition that can cause serious medical problems.

• #47 Anemia – Vitamin B12–Deficiency Anemia | NHLBI, NIH

  https://www.nhlbi.nih.gov/health/anemia/vitamin-b12-deficiency-anemia

  If your doctor diagnoses you with vitamin B12deficiency anemia, your treatment will depend on the cause and seriousness of your condition. Some people need lifelong treatment. […] Some symptoms may take months to improve, depending on how serious they are. Some symptoms related to the brain or the nerves, such as numbness and tingling, may not go away even with treatment. […] Vitamin B12deficiency may cause serious complications, such as bleeding, infections, and problems with your brain or nerves that may be permanent. Babies born to mothers who have vitamin B12deficiency may have developmental delays and birth defects of the brain and spinal cord.

• #48 Symptoms of Pernicious Anaemia | Pernicious Anaemia Society

  https://pernicious-anaemia-society.org/symptoms/

  Pernicious Anaemia predominantly results in neurological and anaemia signs and symptoms, but neuropsychiatric symptoms are often the first manifestation. […] The symptoms often develop (slowly) over many years. […] The symptoms vary in severity from patient to patient; and some patients will have all or nearly all of them while others will have just a few. […] Many of the symptoms are associated with a wide range of other illnesses which contributes towards the problem with patients receiving a late diagnosis. […] It is widely assumed that once the B12 deficiency is corrected the patient will feel well again and his or her symptoms will disappear. Whilst this happens in some patients, the majority of members of the Pernicious Anaemia Society still experience symptoms in various degrees of intensity.

• #49 Symptoms of Pernicious Anaemia | Pernicious Anaemia Society

  https://pernicious-anaemia-society.org/symptoms/

  Nobody knows for sure why this is but it is likely that the later the patient received his or her diagnosis and treatment, the less likely it is that the symptoms will be alleviated once replacement therapy injections of B12 have been given. Another reason for continuing symptoms could be found in the possibility of co-existing conditions (other auto-immune conditions) or co-existing deficiencies (folate, iron) that are regularly found in patients with Pernicious Anaemia.

• #50 Pernicious Anaemia and B12 Deficiency | Doctor

  https://patient.info/doctor/pernicious-anaemia-and-b12-deficiency

  Findings on examination may include pallor, heart failure (if anaemia is severe), lemon tinge to the skin, glossitis and oral ulceration. Neuropsychiatric features may include irritability, depression, psychosis and dementia. Neurological features may include subacute combined degeneration of the spinal cord and peripheral neuropathy. […] People with pernicious anaemia are at increased risk of developing gastric cancer and there is an association with other autoimmune diseases, including primary hypothyroidism, thyrotoxicosis, Hashimoto’s thyroiditis, Addison’s disease, type 1 diabetes, hypoparathyroidism and vitiligo. […] Response to treatment of vitamin B12 deficiency can vary and depends on the cause of the vitamin B12 deficiency. Symptoms may start to improve within 2 weeks, but this may take up to 3 months. It can take much longer for symptoms to disappear altogether. Symptoms may get worse initially during treatment.

• #51 Vitamin B12 Deficiency: Symptoms, Treatment and More

  https://www.verywellhealth.com/vitamin-b12-deficiency-2488570

  Vitamin B12 deficiency can cause fatigue, muscle weakness, and memory problems. […] A vitamin B12 deficiency can cause headaches, fatigue, muscle weakness, and depression. […] Symptoms of vitamin B12 deficiency include fatigue, dizziness, paleness, and a rapid heart rate. […] Vitamin B12 deficiency leads to defective RBCs. This causes anemia. Anemia can make you feel weak and fatigued. […] Vitamin B12 deficiency may cause dementia. These symptoms may include memory loss, cognitive decline, behavioral changes, and problems with self-care. […] Symptoms of vitamin B12 deficiency typically develop gradually over the course of weeks or months. They do not usually improve without treatment. […] Recovery from vitamin B12 deficiency takes time. You may not have any improvement during the first few months of treatment. Improvement may be gradual and may continue for up to six to 12 months. […] If you have a vitamin B12 deficiency, you may have symptoms of anemia, problems with your nerves, sensory issues, or even dementia.

• #52 Vitamin B12 deficiency Guide: Causes, Symptoms and Treatment Options

  https://www.drugs.com/health-guide/vitamin-b12-deficiency.html

  Symptoms tend to develop slowly and may not be recognized immediately. As the condition worsens, common symptoms include: weakness and fatigue, light-headedness and dizziness, palpitations and rapid heartbeat, shortness of breath, a sore tongue that has a red, beefy appearance, nausea or poor appetite, weight loss, diarrhea, yellowish tinge to the skin and eyes. […] If low levels of B12 remain for a long time, the condition also can lead to irreversible damage to nerve cells, which can cause the following symptoms: numbness and tingling in the hands and feet, difficulty walking, muscle weakness, irritability, memory loss, dementia, depression, psychosis. […] The outlook is excellent because this form of anemia responds well to treatment. However, it is possible that nerve cell damage will be permanent. Some residual damage to the nervous system may remain in people who sought treatment late in the illness.

• #53

  https://www.nhs.uk/conditions/vitamin-b12-or-folate-deficiency-anaemia/symptoms/

  It’s important for vitamin B12 or folate deficiency anaemia to be diagnosed and treated as soon as possible. […] Although many of the symptoms improve with treatment, some problems caused by the condition can be irreversible if left untreated. […] The longer the condition goes untreated, the higher the chance of permanent damage.

• #54 Vitamin B12 deficiency can be sneaky and harmful – Harvard Health

  https://www.health.harvard.edu/blog/vitamin-b12-deficiency-can-be-sneaky-harmful-201301105780

  What harm can having too little of vitamin B12 do? Consider this: Over the course of two months, a 62-year-old man developed numbness and a „pins and needles” sensation in his hands, had trouble walking, experienced severe joint pain, began turning yellow, and became progressively short of breath. […] A severe vitamin B12 deficiency can lead to deep depression, paranoia and delusions, memory loss, incontinence, loss of taste and smell, and more. […] Vitamin B12 deficiency can be slow to develop, causing symptoms to appear gradually and intensify over time. It can also come on relatively quickly. Given the array of symptoms a vitamin B12 deficiency can cause, the condition can be overlooked or confused with something else. Vitamin B12 deficiency symptoms may include: strange sensations, numbness, or tingling in the hands, legs, or feet […] difficulty walking (staggering, balance problems) […] anemia […] a swollen, inflamed tongue […] difficulty thinking and reasoning (cognitive difficulties), or memory loss […] weakness […] fatigue. […] Early detection and treatment is important. If left untreated, the deficiency can cause severe neurologic problems and blood diseases.

• #55 Signs and Symptoms of Vitamin B12 Deficiency

  https://www.healthline.com/nutrition/vitamin-b12-deficiency-symptoms

  Because a deficiency in B12 negatively impacts the central nervous system, people with low or deficient B12 levels may feel foggy-headed and have difficulty concentrating and completing tasks. […] Glossitis is a medical term that refers to an inflamed, red, and painful tongue. It can be caused by a B12 deficiency. […] Many adults and kids who have B12 deficiency report experiencing paresthesia, a burning or pins-and-needles sensation in certain areas of the body like the hands and feet. […] B12 deficiency can cause a variety of symptoms, including fatigue, headaches, depression, pale or yellow skin, mental impairment, and pain and inflammation in the mouth and tongue. […] Many of the symptoms caused by low B12 levels are not specific to B12 deficiency, which can cause the condition to go undetected.

• #56 Vitamin B12 Deficiency: Recognition and Management | AAFP

  https://www.aafp.org/pubs/afp/issues/2017/0915/p384.html

  Vitamin B12 deficiency is a common cause of megaloblastic anemia, various neuropsychiatric symptoms, and other clinical manifestations. […] Vitamin B12 deficiency affects multiple systems, and sequelae vary in severity from mild fatigue to severe neurologic impairment. […] The substantial hepatic storage of vitamin B12 can delay clinical manifestations for up to 10 years after the onset of deficiency. […] Symptoms typically include being easily fatigued with exertion, palpitations, and skin pallor. […] Neurologic manifestations are caused by progressive demyelination and can include peripheral neuropathy, areflexia, and the loss of proprioception and vibratory sense. […] Dementia-like disease, including episodes of psychosis, is thought to be associated with more severe and chronic deficiency, although supporting evidence is poor. […] Clinical evaluation seems to show an inverse relationship between the severity of megaloblastic anemia and the degree of neurologic impairment.

• #57 Pernicious Anemia Clinical Presentation: History, Physical Examination

  https://emedicine.medscape.com/article/204930-clinical

  The most common neurologic symptoms in vitamin B12 deficiency include paresthesias, weakness, clumsiness, and an unsteady gait. […] Neurologic symptoms and findings may be present in the absence of anemia. This is more common in patients taking folic acid or on a high-folate diet. […] Older patients may present with symptoms suggesting senile dementia or Alzheimer disease; memory loss, irritability, and personality changes are commonplace. […] A study of four patients revealed that pernicious anemia can lead to hyperhomocysteinemia that is significant enough to lead to venous thrombosis, even in the absence of any other risk factors for thromboembolism. […] The finding of severe anemia in an adult patient whose constitutional symptoms are relatively mild and in whom weight loss is not a major feature should arouse suspicion of pernicious anemia. […] Neurologic findings may occur in the absence of anemia and epithelial manifestations of pernicious anemia, making it more difficult to identify the etiology. If left untreated, they can become irreversible.

• #58

  https://www.nhs.uk/conditions/vitamin-b12-or-folate-deficiency-anaemia/symptoms/

  It’s important for vitamin B12 or folate deficiency anaemia to be diagnosed and treated as soon as possible. […] Although many of the symptoms improve with treatment, some problems caused by the condition can be irreversible if left untreated. […] The longer the condition goes untreated, the higher the chance of permanent damage.

• #59 Vitamin B12 & folate anaemia | NHS inform

  https://www.nhsinform.scot/illnesses-and-conditions/nutritional/vitamin-b12-or-folate-deficiency-anaemia/

  Vitamin B12 or folate deficiency anaemia can cause a wide range of symptoms. These usually develop gradually but can worsen if the condition goes untreated. […] A deficiency in either of these vitamins can cause a wide range of problems, including: extreme tiredness, a lack of energy, pins and needles (paraesthesia), a sore and red tongue, mouth ulcers, muscle weakness, disturbed vision, psychological problems, which may include depression and confusion, problems with memory, understanding and judgement. […] It’s important for vitamin B12 or folate deficiency anaemia to be diagnosed and treated as soon as possible because, although many of the symptoms improve with treatment, some problems caused by the condition can be irreversible. […] Vitamin B12 or folate deficiency anaemia occurs when a lack of either of these vitamins affects the body’s ability to produce fully functioning red blood cells.

• #60 Pernicious Anemia: Definition, Symptoms, Causes & Treatment

  https://my.clevelandclinic.org/health/diseases/22377-pernicious-anemia

  Pernicious anemia, one of the causes of vitamin B12 deficiency, is an autoimmune condition that prevents your body from absorbing vitamin B12. Left untreated, pernicious anemia can cause serious medical issues, including irreversible damage to your nervous system. […] You can have pernicious anemia for several years before noticing changes in your body. Left untreated, pernicious anemia can cause serious medical issues, including irreversible damage to your nervous system. […] Generally speaking, the longer you go without adequate vitamin B12, the more serious your symptoms are. Early on, people may have mild symptoms they may think are caused by other common conditions. […] Long-term low vitamin B12 levels caused by pernicious anemia can affect your nervous system. Symptoms of potential nervous system problems include: confusion, short-term memory loss, depression, loss of balance, numbness and tingling in your hands and feet, problems concentrating, irritability, hallucinations, delusions, optic nerve degeneration that affects your eyesight.

• #61 Pernicious anemia: MedlinePlus Medical EncyclopediaLock

  https://medlineplus.gov/ency/article/000569.htm

  Pernicious anemia is a decrease in red blood cells that occurs when the intestines cannot properly absorb vitamin B12. […] Symptoms may include: Diarrhea or constipation, Nausea, Vomiting, Fatigue, lack of energy, or lightheadedness when standing up or with exertion, Loss of appetite, Pale skin (mild jaundice), Shortness of breath, mostly during exercise, Heartburn, Swollen, red tongue or bleeding gums. […] If you have a low vitamin B12 level for a long time, you can have nervous system damage. Symptoms may include: Confusion, Short-term memory loss, Depression, Loss of balance, Numbness and tingling in the hands and feet, Problems concentrating, Irritability, Hallucinations, Delusions, Optic nerve atrophy. […] It is important to start treatment early. Nerve damage can be permanent if treatment does not start within 6 months of symptoms.

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