Materiały źródłowe

• #1 Polymorphous Light Eruption (PMLE): Symptoms, Causes & Treatments

  https://my.clevelandclinic.org/health/diseases/17888-polymorphous-light-eruption-pmle

  Polymorphous light eruption is the most common skin disease resulting from UV light exposure. […] Polymorphous light eruption is typically diagnosed with a thorough health history and skin examination. A skin biopsy, or tissue sample, may be obtained to confirm the diagnosis. […] If you develop a rash shortly after exposure to sunlight or artificial UV light, ask a healthcare provider if you could have polymorphous light eruption (PMLE).

• #1 Polymorphous light eruption | Health Library | Memorial Health System

  https://www.mhsystem.org/health-library/con-20257399/

  Polymorphous light eruption is a rash caused by sun exposure in people who have developed sensitivity to sunlight. […] Polymorphous light eruption rashes look similar to rashes caused by other diseases, some of which are serious. So its important to get a prompt diagnosis and treatment. […] Your health care provider can probably make a diagnosis of polymorphous light eruption based on a physical exam and your answers to questions. Your health care provider might have you undergo laboratory tests in order to confirm a diagnosis or rule out other conditions. […] Tests may include: Skin biopsy. Your health care provider removes a sample of rash tissue (biopsy) for testing in a lab. […] Phototesting. A specialist in skin conditions (dermatologist) exposes small areas of your skin to measured amounts of UVA and UVB light to try to reproduce the problem. If your skin reacts to UV radiation, youre considered sensitive to sunlight (photosensitive) and may have polymorphous light eruption or another light-induced disorder.

• #1 Polymorphous light eruption – Symptoms & causes – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/polymorphous-light-eruption/symptoms-causes/syc-20355868

  Polymorphous light eruption is a rash caused by sun exposure in people who are sensitive to sunlight. […] Polymorphous light eruption usually goes away on its own without scarring within 10 days. People with severe or persistent rashes may need medicine. […] Polymorphous light eruption rashes look similar to rashes caused by other diseases, some of which are serious. So it’s important to get a prompt diagnosis and treatment. […] The exact cause of polymorphous light eruption isn’t understood. The rash appears in people who have developed sensitivity to sunlight, especially ultraviolet (UV) radiation from the sun or other sources, such as tanning beds. This is called photosensitivity. It leads to immune system activity that causes a rash. […] With polymorphous light eruption, sensitivity to sunlight lessens with repeated exposure. Features of polymorphous light eruption are somewhat predictable: An episode is most likely to occur after the first one or two times of sun exposure after a long period of no exposure, such as in spring or early summer. […] Episodes are less likely to happen as the summer progresses. […] After the first episode, it’s likely to happen each year. Some people gradually become less sensitive over several years and eventually no longer experience the yearly rash.

• #1 Polymorphous Light Eruption – Dermpath Diagnostics

  https://www.dermpathdiagnostics.com/clinicians/polymorphous-light-eruption/

  Polymorphous Light Eruption is a skin condition that occurs as a result of photosensitivity (sensitive to UV radiation). […] Individuals that are sensitive to the light can experience a rash that appears mainly on the face, neck, sternal region, arms and dorsa of hands. […] The pruritic rash consists of papules, plaques, papulovesicles lesions can occur up to a day after exposure to UV radiation. […] Treatment for polymorphous light eruption is not necessary because the rash will usually resolve on its own between seven to ten days. […] Recommendations include avoiding excessive sunlight, wearing protective clothing, and using sunscreens with at least 15 SPF (sun protection factor). […] Affects around 10% of individuals in the United States. […] Ultraviolet radiation. […] Pruritic red rash develops up to a day after being in the sun. […] Papules, plaques, papulovesicles, and erythema multiforme lesions. […] Moderately dense superficial and deep perivascular infiltrate of lymphocytes. Marked edema of the papillary dermis.

• #1 Polymorphic light eruption (PMLE) — DermNet

  https://dermnetnz.org/topics/polymorphic-light-eruption

  A clinical diagnosis of polymorphic light eruption can be made based on a history of a pruritic eruption occurring following sun exposure and previous episodes in spring or summer. Accurate diagnosis relies on the exclusion of other photosensitive conditions. […] To exclude other photosensitive conditions a skin biopsy may be considered. The histopathology of PMLE is nonspecific, variable, and can include: Epidermal spongiosis, Superficial and deep perivascular and peri-appendageal lymphohistiocytic infiltrate, often with scattered eosinophils and neutrophils. Significant papillary dermal oedema is common in more advanced cases. […] Direct immunofluorescence is negative in PMLE. […] Phototesting can be considered but is not carried out in all patients with PMLE. A provocative test in which UV radiation is used to confirm the diagnosis. 60% of patients yielding a positive eruption are clinically and histopathologically consistent with PMLE. The patient is exposed ideally to UVA (alternatively UVB) daily for 35 days to a small area of skin (such as the forearms or v of neck), which elicits an eruption.

• #1 Polymorphous light eruption // Middlesex Health

  https://middlesexhealth.org/learning-center/diseases-and-conditions/polymorphous-light-eruption

  Polymorphous light eruption is a rash caused by sun exposure in people who have developed sensitivity to sunlight. […] Polymorphous light eruption usually goes away on its own without scarring within 10 days. […] Polymorphous light eruption rashes look similar to rashes caused by other diseases, some of which are serious. So it’s important to get a prompt diagnosis and treatment. […] Your health care provider can probably make a diagnosis of polymorphous light eruption based on a physical exam and your answers to questions. Your health care provider might have you undergo laboratory tests in order to confirm a diagnosis or rule out other conditions. […] Your health care provider might need to rule out other disorders characterized by light-induced skin reactions. […] Treatment of polymorphous light eruption usually isn’t needed because the rash usually goes away on its own within 10 days.

• #1 Polymorphic Light Eruption – StatPearls – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK430886/

  Twin studies indicate a polygenic model may explain familial clustering. […] Skin biopsy shows upper dermal edema, and a dense perivascular and periadnexal lymphocytic infiltrate without vasculitis. […] Management requires determining what provokes the eruption and then attempting to minimize this, while at the same time gradually increasing exposure to induce hardening. […] PLE is a relatively common skin disorder that is not easy to diagnose or manage. The disorder may be confused with many other skin disorders and thus is best managed by a dermatologist.

• #1

  https://www.kuh.ku.edu.tr/mayo-clinic-care-network/mayo-clinic-health-information-library/diseases-conditions/polymorphous-light-eruption

  Polymorphous light eruption is a rash caused by sun exposure in people who have developed sensitivity to sunlight. The condition is also known as polymorphic light eruption, sun allergy and sun poisoning. Polymorphous light eruption usually goes away on its own without scarring within 10 days. Your health care provider can probably make a diagnosis of polymorphous light eruption based on a physical exam and your answers to questions. Your health care provider might have you undergo laboratory tests in order to confirm a diagnosis or rule out other conditions. Tests may include: Skin biopsy. Your health care provider removes a sample of rash tissue (biopsy) for testing in a lab. Blood tests. A member of your care team draws blood for testing in a lab. Phototesting. A specialist in skin conditions (dermatologist) exposes small areas of your skin to measured amounts of UVA and UVB light to try to reproduce the problem. If your skin reacts to UV radiation, you’re considered sensitive to sunlight (photosensitive) and may have polymorphous light eruption or another light-induced disorder. Polymorphous light eruption rashes look similar to rashes caused by other diseases, some of which are serious. So it’s important to get a prompt diagnosis and treatment.

• #1 Polymorphous Light Eruption Workup: Approach Considerations, Laboratory Studies, Other Tests

  https://emedicine.medscape.com/article/1119686-workup

  If a lesion (eg, a papule or vesicle) develops, biopsy can be performed for confirmation. Histologically, a superficial and deep perivascular lymphocytic infiltrate is apparent with dermal edema. […] Mucin, which is thought to distinguish PMLE from lupus, can be present in skin biopsy specimens from PMLE patients. […] The most striking feature of the biopsy specimen from a patient with PMLE is edema in the upper part of the dermis. Tight perivascular lymphocytic infiltrate is observed in the upper and middle dermis. […] The polymorphous light eruption-severity assessment score does not reliably predict the results of phototesting.

• #1 Polymorphous Light Eruption Workup: Approach Considerations, Laboratory Studies, Other Tests

  https://emedicine.medscape.com/article/1119686-workup

  The diagnosis of polymorphous (polymorphic) light eruption (PMLE) is usually based on the clinical picture and the history. […] Laboratory tests can be performed to rule out other dermatoses other than PMLE, such as erythropoietic protoporphyria or lupus erythematosus. Antinuclear antibody (ANA), anti-Ro (SS-A), and anti-La (SS-B) tests, as well as urine, stool, and blood porphyrin levels, should be obtained when clinically indicated. […] Normal titers of ANA, as well as normal urine, stool, and blood porphyrin levels, support the diagnosis. […] Results of phototesting in PMLE patients have been controversial, ranging from ability to reproduce the eruption by repeat phototesting in 60-100% of patients to inability to reproduce it except in patients who are highly photosensitive. […] A delayed reading at 1 week may also be helpful. Test results are often positive in PMLE; however, a negative result does not exclude the diagnosis.

• #1 Polymorphous Light Eruption – PubMed

  https://pubmed.ncbi.nlm.nih.gov/29124691/

  Polymorphous light eruption (PLE) is the commonest immuno-mediated photodermatosis. Its diagnosis is based on history, morphology and phototests. Usually, MED is normal, but the provocative phototests with UVA or UVB reproduce the spontaneous lesions in about 50% of the patients. […] PLE is considered as a delayed hypersensitivity response to newly UV induced, but still unidentified, antigen(s). […] Therapy is based mainly on topical or systemic corticosteroids.

• #1 Polymorphous light eruption – Wikipedia

  https://en.wikipedia.org/wiki/Polymorphous_light_eruption

  Polymorphous light eruption (PLE) presents with itchy red small bumps on sun-exposed skin, particularly face, neck, forearms and legs. […] The diagnosis of PLE is typically made by assessing the history and clinical observations. Any investigations are usually to exclude other conditions, particularly lupus and porphyria. […] Blood tests are usually normal. However, positive antinuclear antibody and extractable nuclear antigen (anti-Ro/La) in low titre may be found, even in the absence of other criteria to suggest a diagnosis of lupus erythematosus. […] Photoprovocation tests are usually not required but may be undertaken by specialised centres in winter. […] When a decision to undertake this is made, a small area of the frequently affected skin is exposed to varying doses of UVA and minimal erythema dose (MED) of broadband UVB for three consecutive days.

• #1 Polymorphic light eruption: A diagnosis of exclusion | MDedge

  https://community.the-hospitalist.org/content/polymorphic-light-eruption-diagnosis-exclusion

  Polymorphic light eruption is the most common of all the photodermatoses, yet few physicians will ever actually see the rash in their office, according to Dr. Vincent A. DeLeo. […] „PMLE is a clinical diagnosis you make when you’ve ruled out photoallergic contact dermatitis and lupus. It’s a diagnosis of exclusion,” explained Dr. DeLeo, chairman of the department of dermatology at St. Lukes-Roosevelt Hospital Center and Beth Israel Medical Center, both in New York. […] The differential diagnosis involves photoallergic contact dermatitis and lupus, both of which, like PMLE, feature recurrent, persistent rashes that erupt after a delay in response to sun exposure. […] The plaque form of PMLE looks morphologically like lupus erythematosus (LE). But LE can be ruled out on the basis of negative results for antinuclear antibody, anti-Ro, and anti-La testing.

• #1 Polymorphous Light Eruption Differential Diagnoses

  https://emedicine.medscape.com/article/1119686-differential

  Some physicians regard actinic prurigo (AP) as a distinct photodermatosis, and other physicians consider it an insidiously developing, markedly excoriated variant of polymorphous (polymorphic) light eruption (PMLE). AP is characterized by a high incidence of atopy and familial predisposition. It is likely to involve covered skin. […] A 2010 study by Gronhagen et al reported on the importance of differentiating systemic lupus erythematosus and cutaneous lupus erythematosus from PMLE. In this study, 23% of 260 systemic lupus erythematosus patients had cutaneous lupus erythematosus, and a history of PMLE was found in 42%. The history of PMLE can proceed the typical eruption of cutaneous lupus erythematosus. […] The polymorphous light eruption-severity assessment score does not reliably predict the results of phototesting. […] Polychromatic phototest sensibility is superior to UVA phototest in polymorphic light eruptions.

• #1 Polymorphous light eruption – Wikipedia

  https://en.wikipedia.org/wiki/Polymorphous_light_eruption

  Depending on the clinical signs, histology of a skin biopsy may vary. […] The photosensitivity connected with lupus erythematosus is the main condition that may appear like PLE. However, the rash of lupus is inclined to be more persistent. […] PLE does not increase the risk of lupus. […] The application of topical corticosteroids may lessen the redness and itch, and for preventing predictable holiday flare-ups, short courses of oral corticosteroids are sometimes considered. […] Management entails regulating triggers whilst simultaneously inducing „hardening”; that is, steadily increasing exposure to sunlight, as light sensitivity is reduced with repeated sun exposure.

• #1

  https://www.ijord.com/index.php/ijord/article/view/296

  Polymorphous light eruption (PMLE) is the most common endogenous photodermatosis. […] The study was conducted between October 2010 and March 2012. 78 patients with clinical diagnosis of PMLE, who attended Dermatology OPD at Dr. D. Y. Patil Hospital and Research Institute, Kolhapur were included in present study. […] Majority of patients were housewives. Itching was the most common symptom. […] Most of the patients developed lesions within 30 minutes of sun exposure. […] History of recurrence of PMLE was noted in 30 patients. Only 6 patients gave family history of PMLE because of milder nature of the disease along with difference in clothing and working environment.

• #1 Polymorphous light eruption – UpToDate

  https://www.uptodate.com/contents/polymorphous-light-eruption

  Polymorphous light eruption (PMLE) is the most common idiopathic photodermatosis; it is sometimes called „sun poisoning” or „sun allergy.” PMLE usually presents as a pruritic rash in sun-exposed areas hours to days after ultraviolet (UV) light exposure and persists for several days before subsiding. […] Juvenile spring eruption is a variant of PMLE. […] DIAGNOSIS Clinical Skin biopsy Phototesting.

• #1 Sun Allergy (Photosensitivity) – Harvard Health

  https://www.health.harvard.edu/a_to_z/sun-allergy-photosensitivity-a-to-z

  Despite the name, a „sun allergy” is not truly an allergy to the sun. Instead, it is an immune system reaction in the skin triggered by sunlight, most often causing an itchy red rash. The medical term for this condition is Polymorphous Light Eruption (PMLE). […] If you have more severe sun-related symptoms especially hives, blisters or small areas of bleeding under the skin your doctor will need to make the diagnosis. In most cases, your doctor can confirm that you have PMLE or actinic prurigo based on your symptoms, your medical history, family history (especially American Indian ancestry) and a simple examination of your skin. […] If you have symptoms of a photoallergic eruption, the diagnosis may take some detective work. Your doctor will begin by reviewing your current medicines as well as any skin lotions, sunscreens or colognes you use. […] If you have symptoms of solar urticaria, your doctor may confirm the diagnosis by using photo-testing to reproduce your hives.

• #1 2013.3-29.Polymorphous – Our Dermatology Online

  https://www.odermatol.com/issue-in-html/2013-3-29-polymorphous/

  Polymorphous light eruption is the most common idiopathic photodermatosis. It is a sun induced cutaneous reaction characterized by onset itchy erathematous papules, plaques, vesicles or erythema multiforme type of lesions after brief exposure to sunlight. […] Diagnosis is mainly on clinical grounds. […] Polymorphous Light Eruption (PMLE), also termed Polymorphic Light Eruption, is the most common photodermatosis encountered in clinical practice. […] The reaction usually follows the brief spring or summer sun exposure and occurs after a latent period of hours to days. […] The course of this condition is highly variable, ranging from complete remission to development of debilitating symptoms and possibly other autoimmune disorders. […] The mild disease of many patients is satisfactorily controlled by the moderation of sun exposure at times of high UV intensity and regular application of broad-spectrum sunscreens with a high protection factor particularly against UVA.

• #1 Polymorphous Light Eruption: Causes, Symptoms, and Treatment

  https://www.medicoverhospitals.in/diseases/polymorphous-light-eruption/

  Diagnosing PLE involves a combination of clinical evaluation, patient history, and, sometimes, diagnostic tests. Heres how healthcare providers approach the diagnosis: […] A thorough clinical examination is the first step in diagnosing PLE. Dermatologists look for the characteristic skin eruptions and their distribution pattern, which is typically limited to sun-exposed areas. […] Gathering a detailed patient history is crucial. Patients are often asked about their sun exposure habits, the onset and duration of symptoms, and any family history of similar conditions. […] Phototesting involves exposing small areas of the patient’s skin to controlled amounts of UVA and UVB radiation. This test helps in confirming the diagnosis by reproducing the skin eruptions seen in PLE. […] In some cases, a skin biopsy may be performed to rule out other conditions with similar presentations, such as lupus erythematosus or dermatomyositis. The biopsy sample is examined under a microscope to identify any characteristic histopathological features.

• #1

  https://journals.lww.com/cddr/fulltext/2023/07030/a_clinicopathological_study_of_polymorphous_light.2.aspx

  Polymorphous light eruption (PLE) is the most common idiopathic photodermatoses, with a wide range of clinical presentations that tends to mimic a number of dermatoses. […] The aim was to study the clinicopathological profile in patients diagnosed with PLE. […] This was a cross-sectional, descriptive study of seventy clinically diagnosed cases of PLE over a period of 1 year, wherein following patient enrolment, they underwent a thorough clinical evaluation, followed by a skin biopsy that was studied categorically. […] Histological examination with certain specific criteria enables the clinician to arrive at a concrete conclusion in those cases where clinical findings alone pose diagnostic difficulties. […] It therefore becomes imperative on the part of the clinician to perform a skin biopsy along with special stains (if warranted), in order to aptly evaluate these patients, and arrive at a definitive diagnosis, so that appropriate treatment can be promptly instituted.

• #1

  https://journals.lww.com/cddr/fulltext/2023/07030/a_clinicopathological_study_of_polymorphous_light.2.aspx

  We postulated diagnostic criteria (after studying the sensitivity and specificity of these criteria in combination, while diagnosing PLE) that grouped patients into the following three categories: namely patients having definitive PLE, possible PLE, and probable PLE. […] Based on our criteria, we observed a definitive diagnostic histologic pattern in 71.4% of our patients, a possible histologic pattern in 15.7%, and probable microscopic findings of PLE in the remaining 11.4%. […] In our study, we detected rarer clinical types of PLE to be more common when compared to the usual morphological patterns reprised in previous studies. […] Although the diagnosis of PLE is primarily clinical, histopathology becomes mandatory in those cases where phenotypic overlap with other dermatoses exist.

• #1 Polymorphous light eruption – Symptoms, diagnosis and treatment | BMJ Best Practice US

  https://bestpractice.bmj.com/topics/en-us/626

  Polymorphous light eruption typically onsets during adolescence and young adulthood. […] Mainly affects women. […] Typically, manifests after exposure to intense ultraviolet radiation (UVR); clinical symptoms last several days and remission occurs without complication. […] Papules/papulovesicles and plaques on exposed sites are characteristic. […] Key diagnostic factors include recurrent history of lesions following ultraviolet radiation exposure, young women and adolescents, family history of PLE, severe itching, reduced symptoms over the course of a year, erythematous patches, papules, plaques, and vesicles. […] Tests to consider include phototesting and photoprovocation, and skin biopsy.

• #1 Polymorphous light eruptions – Indian Journal of Skin Allergy

  https://skinallergyjournal.com/polymorphous-light-eruptions/

  In PMLE, photo provocation test on a previously involved skin shows a positive response to UVA in more than 50% of patients, followed by both UVA/UVB in about 30%, and less common sensitivity is seen to UVB alone. […] Management of PMLE includes photoprotective measures, systemic photoprotection, photo-hardening, and topical and oral corticosteroids. […] Polymorphous light eruption is common photodermatoses with variable clinical presentation. It has to be differentiated from its close mimics by proper clinical history and distribution of skin lesions.

• #1 Polymorphous Light Eruption – Causes, Symptoms And Treatment

  https://www.netmeds.com/health-library/post/polymorphous-light-eruption-causes-symptoms-and-treatment?srsltid=AfmBOopHK6Luy07UInxuLfj2X6AmcqAJvimXCBtuNnaPsWn_tn8oBbeZ

  The doctor first analyses the patients external physical parameters and makes a note of any incidents of PLE that may have been recorded in his or her family history. […] Afterwards, laboratory assessments such as skin biopsy and blood tests are performed to confirm the incidence of PLE. […] Hence, one should always consult with a physician promptly upon developing any signs of PLE, to ensure accurate diagnosis and appropriate treatment can be provided.

• #2 Polymorphic Light Eruption – StatPearls – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK430886/

  Polymorphic light eruption is the most common form of immunologically mediated photosensitivity dermatoses. Exposure to sunlight in spring or summer results in an irritable rash that resolves within a few days, providing further exposure is avoided. […] Polymorphic light eruption is the most common form of immunologically mediated photosensitivity dermatoses. Exposure to sunlight in spring or summer results in an irritable rash that resolves within a few days, providing further exposure is avoided. […] The cause of polymorphic light eruption is unknown. It is postulated that there is a delayed hypersensitivity reaction to an endogenous antigen expressed after exposure to sunlight or artificial sources of ultraviolet (UV) radiation. […] The prevalence of polymorphic light eruption varies worldwide. Affected individuals may experience it every time they go outdoors, or only occasionally.

• #2 Polymorphous light eruption – Diagnosis & treatment – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/polymorphous-light-eruption/diagnosis-treatment/drc-20355872

  Your healthcare professional can probably make a diagnosis of polymorphous light eruption based on a physical exam and your answers to questions. You might undergo laboratory tests in order to confirm a diagnosis or rule out other conditions. Tests may include: […] A specialist in skin conditions (dermatologist) exposes small areas of your skin to measured amounts of ultraviolet A (UVA) and ultraviolet B (UVB) light to try to reproduce the problem. If your skin reacts to ultraviolet (UV) radiation, you’re considered sensitive to sunlight (photosensitive) and may have polymorphous light eruption or another light-induced disorder. […] For polymorphous light eruption, some basic questions to ask your healthcare team include: […] Your healthcare team will ask you a number of questions about your symptoms and your medical history, such as:

• #2 Polymorphous Light Eruption: Symptoms, Causes, Diagnosis, Treatments

  https://resources.healthgrades.com/right-care/skin-hair-and-nails/polymorphous-light-eruption

  Polymorphous light eruption is a form of sun allergy. It is a seasonal rash that appears in the spring or summer. This article explains polymorphous light eruption symptoms, causes, diagnosis, and treatment. […] PMLE is a clinical diagnosis. This means doctors mainly rely on your medical history and symptoms to make the diagnosis. Your description of when and how the rash appears will be very helpful. […] In some cases, doctors may order tests to rule out other diagnoses, including: blood tests to look for antigens and antibodies, skin biopsy to confirm polymorphous light eruption skin changes or rule out other possible skin conditions, phototesting, which uses light to test small areas of skin for UV and visible light sensitivity.

• #2 Polymorphic light eruption (PMLE) — DermNet

  https://dermnetnz.org/topics/polymorphic-light-eruption

  A clinical diagnosis of polymorphic light eruption can be made based on a history of a pruritic eruption occurring following sun exposure and previous episodes in spring or summer. Accurate diagnosis relies on the exclusion of other photosensitive conditions. […] To exclude other photosensitive conditions a skin biopsy may be considered. The histopathology of PMLE is nonspecific, variable, and can include: Epidermal spongiosis, Superficial and deep perivascular and peri-appendageal lymphohistiocytic infiltrate, often with scattered eosinophils and neutrophils. Significant papillary dermal oedema is common in more advanced cases. […] Direct immunofluorescence is negative in PMLE. […] Phototesting can be considered but is not carried out in all patients with PMLE. A provocative test in which UV radiation is used to confirm the diagnosis. 60% of patients yielding a positive eruption are clinically and histopathologically consistent with PMLE. The patient is exposed ideally to UVA (alternatively UVB) daily for 35 days to a small area of skin (such as the forearms or v of neck), which elicits an eruption.

• #2

  https://www.va.gov/vetapp09/files2/0910938.txt

  Resolving doubt in the Veteran’s favor, polymorphous skin eruption (claimed as skin rash) is causally or etiologically related to service, to include sun exposure. […] Polymorphous skin eruption was incurred in or aggravated by service. […] The examiner then diagnosed polymorphous light eruption by exclusion, noting that a light-induced, pruritic eruption occurring with intense sun exposure was consistent with the diagnosis. […] All though not conclusive, resolving doubt in her favor, the Board finds that the medical evidence of record supports a link between the Veteran’s diagnosed polymorphous light eruption and her active service. […] The VA examiner gave a diagnosis of polymorphous light eruption and stated that it would be speculative to relate the problem to some kind of exposure in the Persian Gulf, „other than to sunlight.” […] In other words, both the private and VA examiner, in essence, related the Veteran’s polymorphous light eruption to the exposure to sunlight during service.

• #2 Polymorphic light eruption: A diagnosis of exclusion | MDedge

  https://community.the-hospitalist.org/content/polymorphic-light-eruption-diagnosis-exclusion

  Polymorphic light eruption is the most common of all the photodermatoses, yet few physicians will ever actually see the rash in their office, according to Dr. Vincent A. DeLeo. […] „PMLE is a clinical diagnosis you make when you’ve ruled out photoallergic contact dermatitis and lupus. It’s a diagnosis of exclusion,” explained Dr. DeLeo, chairman of the department of dermatology at St. Lukes-Roosevelt Hospital Center and Beth Israel Medical Center, both in New York. […] The differential diagnosis involves photoallergic contact dermatitis and lupus, both of which, like PMLE, feature recurrent, persistent rashes that erupt after a delay in response to sun exposure. […] The plaque form of PMLE looks morphologically like lupus erythematosus (LE). But LE can be ruled out on the basis of negative results for antinuclear antibody, anti-Ro, and anti-La testing.

• #2 Polymorphic light eruption: A diagnosis of exclusion | MDedge

  https://www.mdedge.com/content/polymorphic-light-eruption-diagnosis-exclusion

  Polymorphic light eruption is the most common of all the photodermatoses, yet few physicians will ever actually see the rash in their office, according to Dr. Vincent A. DeLeo. […] PMLE is a clinical diagnosis you make when you’ve ruled out photoallergic contact dermatitis and lupus. It’s a diagnosis of exclusion, explained Dr. DeLeo. […] The differential diagnosis involves photoallergic contact dermatitis and lupus, both of which, like PMLE, feature recurrent, persistent rashes that erupt after a delay in response to sun exposure. […] The plaque form of PMLE looks morphologically like lupus erythematosus (LE). But LE can be ruled out on the basis of negative results for antinuclear antibody, anti-Ro, and anti-La testing.

• #2 Photosensitivity disorders (photodermatoses): Clinical manifestations, diagnosis, and treatment – UpToDate

  https://www.uptodate.com/contents/photosensitivity-disorders-photodermatoses-clinical-manifestations-diagnosis-and-treatment/print

  Photosensitivity disorders of the skin are conditions in which an abnormal cutaneous response occurs after exposure to ultraviolet (UV) radiation or visible light. […] Polymorphous light eruption (PMLE) is the most common idiopathic photodermatosis and is sometimes colloquially called „sun poisoning” or „sun allergy.” […] PMLE and juvenile spring eruption, a PMLE variant, are reviewed separately.

• #2 Juvenile spring eruption in a young boy

  https://www.contemporarypediatrics.com/view/juvenile-spring-eruption-in-a-young-boy

  Juvenile spring eruption (JSE) is a variant of polymorphous light eruption (PMLE), which is the most common form of light induced dermatosis. […] Polymorphous light eruption is also known as polymorphic light eruption, prurigo aestivalis, dermatographia photogenica, and erythema perstans solare. […] Differential diagnosis includes photosensitivity associated with lupus erythematosus and photosensitivity dermatitis. […] Management of JSE includes both preventive and curative measures. […] The first choice is topical steroids, which show reduction of lesions and itching due to their anti-inflammatory properties. […] Systemic corticosteroids and immunosuppressives are indicated in severe cases of classic PMLE.

• #2 Polymorphous Light Eruption Differential Diagnoses

  https://emedicine.medscape.com/article/1119686-differential

  Some physicians regard actinic prurigo (AP) as a distinct photodermatosis, and other physicians consider it an insidiously developing, markedly excoriated variant of polymorphous (polymorphic) light eruption (PMLE). AP is characterized by a high incidence of atopy and familial predisposition. It is likely to involve covered skin. […] A 2010 study by Gronhagen et al reported on the importance of differentiating systemic lupus erythematosus and cutaneous lupus erythematosus from PMLE. In this study, 23% of 260 systemic lupus erythematosus patients had cutaneous lupus erythematosus, and a history of PMLE was found in 42%. The history of PMLE can proceed the typical eruption of cutaneous lupus erythematosus. […] The polymorphous light eruption-severity assessment score does not reliably predict the results of phototesting. […] Polychromatic phototest sensibility is superior to UVA phototest in polymorphic light eruptions.

• #2

  https://journals.lww.com/cddr/fulltext/2023/07030/a_clinicopathological_study_of_polymorphous_light.2.aspx

  We postulated diagnostic criteria (after studying the sensitivity and specificity of these criteria in combination, while diagnosing PLE) that grouped patients into the following three categories: namely patients having definitive PLE, possible PLE, and probable PLE. […] Based on our criteria, we observed a definitive diagnostic histologic pattern in 71.4% of our patients, a possible histologic pattern in 15.7%, and probable microscopic findings of PLE in the remaining 11.4%. […] In our study, we detected rarer clinical types of PLE to be more common when compared to the usual morphological patterns reprised in previous studies. […] Although the diagnosis of PLE is primarily clinical, histopathology becomes mandatory in those cases where phenotypic overlap with other dermatoses exist.

• #2

  https://sunsaferx.com/blogs/health-wellness/polymorphous-light-eruption-treatment-prevention?srsltid=AfmBOor327jM56u_byp5U0I7hD-HVc4XszunZCQVPByanGsmbTeWtWY_

  Polymorphous light eruption can often be diagnoses by a doctor from a description of the symptoms, the length of the rash, and the history of the individual. A skin rash from sunlight that appears hours or within a day or two of light exposure, and that clears after a few days to a week or two, is a common sign. This sun rash is confined to exposed areas of skin. […] Blood tests and a skin sample may also be used to rule out other conditions. Skin biopsies that show PLE are characterized by edema (oedema) and dense perivascular lymphocytic infiltrate. Eczema-like symptoms may also be present. Additionally, phototesting can be used to confirm a diagnosis. This involves provoking a small area of skin with light (usually UVA) to see how the skin reacts. […] Polymorphous light eruption usually resolves on its own within a week or two. Since rashes will normally heal if sun exposure is avoided, further sun rash treatment may not be necessary.

Zobacz więcej