Materiały źródłowe

• #1 Erythema Nodosum: Symptoms, Causes & Treatment

  https://my.clevelandclinic.org/health/diseases/24565-erythema-nodosum

  Erythema nodosum causes red to purple, painful bumps to form on your skin. These bumps can form anywhere on your body, but most often affect the front of your shins. The bumps can resolve on their own within weeks to months. […] Erythema nodosum causes bumps to form on your skin. These bumps can be tender, painful and warm to the touch, which can make the affected area of your skin feel uncomfortable. You might notice your skin change color from a red to a purple or brown as your skin heals before it returns to your natural skin tone. […] Symptoms of erythema nodosum range in severity for each person and could include: Bumps (nodules) on your skin. The bumps are warm to the touch and red to purple, similar to a bruise. Bumps are tender and painful. Bumps fade into a flat, purple to brown patch after several weeks.

• #2 Erythema Nodosum: A Sign of Systemic Disease | AAFP

  https://www.aafp.org/pubs/afp/issues/2007/0301/p695.html

  Erythema nodosum, a painful disorder of the subcutaneous fat, is the most common type of panniculitis. The hallmark of erythema nodosum is tender, erythematous, subcutaneous nodules that typically are located symmetrically on the anterior surface of the lower extremities. Erythema nodosum tends to be self-limited. Painful, symmetric, red nodules Anterior legs most common location Involutes in weeks with bruise-like appearance Does not ulcerate; tends to heal completely. Initially, erythema nodosum nodules can be firm, but they usually become more fluctuant during the clinical evolution. Individual nodules may last for two weeks; new outcroppings may continue to arise for up to six weeks. These nodules often take approximately one to two months to heal completely and may assume a bruise-like appearance as they fade. A prodrome commonly occurs as early as one to three weeks before the onset of erythema nodosum, regardless of the etiology. Specific symptoms may include weight loss, malaise, low-grade fever, cough, and arthralgia with or without arthritis. Arthralgias have been known to persist for up to two years after the resolution of erythema nodosum. Erythema nodosum migrans, subacute nodular migratory panniculitis, and chronic erythema nodosum, disorders classically considered distinct from erythema nodosum, now are considered to be variants in the same disease spectrum.

• #3 Erythema Nodosum Autoimmunity: Symptoms & Treatment Guide | Maggie Yu MD, IFMCP

  https://drmaggieyu.com/blog/erythema-nodosum-autoimmunity-symptoms-treatment-guide/

  Erythema nodosum presents with tender, erythematous nodules. These are usually found on the anterior legs. The nodules can be red and painful. They often feel warm to the touch. […] Joint pain is another symptom of erythema nodosum. This condition can cause arthritis-like symptoms. Patients might experience swelling in their joints. […] In acute cases, symptoms appear suddenly. The nodules develop quickly over a few days. These early lesions are very painful. […] Chronic erythema nodosum has a different pattern. Symptoms persist for months or even years. Nodules may come and go over time. […] Erythema nodosum is self-limiting. This means it often resolves on its own. The condition typically lasts for weeks to months. […] The main sign of erythema nodosum is subcutaneous nodules. These are firm lumps beneath the skin. They can be painful and warm to touch. […] Erythema nodosum involves septal panniculitis. This is inflammation of the fat layer under the skin, termed lesions. It mainly affects the septa, or walls, between fat lobules, with evidence of lesions.

• #4 Disease – Erythema nodosum

  https://ssl.adam.com/content.aspx?productid=617&isarticlelink=false&pid=1&gid=000881&site=makatimed.adam.com&login=MAKA1603

  Erythema nodosum is most common on the front of the shins. It may also occur on other areas of the body such as buttocks, calves, ankles, thighs, and arms. […] The lesions begin as flat, firm, hot, red, painful lumps that are about 1 inch (2.5 centimeters) across. Within a few days, they may become purplish in color. Over several weeks, the lumps fade to a brownish, flat patch. […] Other symptoms may include: Fever, General ill feeling (malaise), Joint aches, Skin redness, inflammation, or irritation, Swelling of the leg or other affected area. […] Symptoms most often go away within about 6 weeks, but may return.

• #5 Erythema Nodosum | Loma Linda University Health

  https://lluh.org/conditions/erythema-nodosum

  Erythema nodosum is a skin condition of the fat that lies just below your skin (the subcutaneous layer). It causes tender, red bumps to form, usually on the shins that may become purplish in color within a few days. The bumps may also appear on other parts of the body, such as the ankles, thighs, arms, or face. […] Erythema nodosum is usually not a serious condition. Symptoms often go away within 6 weeks. But they may appear again. As the bumps fade, they may look like bruises. […] These are the most common symptoms of erythema nodosum: Red, sore bumps on the shins that may become purplish in color within a few days, Fever, Fatigue, Joint pain or swelling, Enlarged lymph nodes in the chest. […] Erythema nodosum is a skin condition. It causes tender, red bumps, which may become purplish in color within a few days. They usually develop on the shins. […] Along with the bumps, symptoms include fever and joint pain.

• #6 Erythema nodosum – Wikipedia

  https://en.wikipedia.org/wiki/Erythema_nodosum

  Erythema nodosum is an inflammatory condition characterized by inflammation of subcutaneous fat tissue, resulting in painful red/blue lumps or nodules that are usually seen symmetrically on both shins, on the thighs, arms, and elsewhere. It typically resolves spontaneously within 30 days. It is common in young people aged 12-20 years. […] The first signs of erythema nodosum are often flu-like symptoms such as a fever, cough, malaise, and aching joints. Some people also experience stiffness or swelling in the joints and weight loss. […] Erythema nodosum is characterised by 1-2 inch (25-51 mm) nodules (rounded lumps) below the skin surface, usually on the shins. These subcutaneous nodules can appear anywhere on the body, but the most common sites are the shins, arms, thighs, and torso. Each nodule typically disappears after around two weeks, though new ones may continue to form for up to six or eight weeks. A new nodule usually appears red and is hot and firm to the touch. The redness starts to fade and it gradually becomes softer and smaller until it disappears. Each nodule usually heals completely without scarring over the course of about two weeks. Joint pain and inflammation sometimes continue for several weeks or months after the nodules appear. […] Erythema nodosum is self-limiting and usually resolves itself within 3-6 weeks. A recurring form does exist, and in children, it is attributed to repeated infections with streptococcus.

• #7 Erythema Nodosum: A Sign of Systemic Disease | AAFP

  https://www.aafp.org/pubs/afp/issues/2007/0301/p695.html

  Erythema nodosum, a painful disorder of the subcutaneous fat, is the most common type of panniculitis. The hallmark of erythema nodosum is tender, erythematous, subcutaneous nodules that typically are located symmetrically on the anterior surface of the lower extremities. Erythema nodosum tends to be self-limited. Painful, symmetric, red nodules Anterior legs most common location Involutes in weeks with bruise-like appearance Does not ulcerate; tends to heal completely. Initially, erythema nodosum nodules can be firm, but they usually become more fluctuant during the clinical evolution. Individual nodules may last for two weeks; new outcroppings may continue to arise for up to six weeks. These nodules often take approximately one to two months to heal completely and may assume a bruise-like appearance as they fade. A prodrome commonly occurs as early as one to three weeks before the onset of erythema nodosum, regardless of the etiology. Specific symptoms may include weight loss, malaise, low-grade fever, cough, and arthralgia with or without arthritis. Arthralgias have been known to persist for up to two years after the resolution of erythema nodosum. Erythema nodosum migrans, subacute nodular migratory panniculitis, and chronic erythema nodosum, disorders classically considered distinct from erythema nodosum, now are considered to be variants in the same disease spectrum.

• #8 Erythema nodosum: Causes, symptoms, and pictures

  https://www.medicalnewstoday.com/articles/320829

  Erythema nodosum (EN) symptoms can include painful bumps under the skin on the legs, fever, fatigue, and joint swelling. […] EN can develop suddenly without any warning signs. Some people experience non-specific symptoms before EN lesions develop. […] Many of the early signs of EN, especially joint pain, continue once the sores develop and may last for weeks to months after they have gone. […] Common early signs and symptoms of EN include: fever, unexplained exhaustion, lung, throat, or nose infections, joint and muscle pain and weakness, swollen joints, often the ankles and knees, conjunctivitis, cough, weight loss. […] The symptoms vary between individuals, but once EN lesions have developed, they normally have a few common characteristics. […] Most EN sores are usually: very painful, hot to touch, bright red for a week to 10 days then fade to purple or blue, on both sides of the body equally, on the front of the shins, but also sometimes the ankles, knees, thighs, and forearms, slightly raised, rounded in shape, non-ulcerating, or not causing breaks or tears in the surface of the skin, varying in size from a grape to a grapefruit, but mostly between 1 centimeter (cm) and 5 cm, varying in number, from 2 to more than 50, shiny in appearance.

• #9 Erythema nodosum | Better Health Channel

  https://www.betterhealth.vic.gov.au/health/conditionsandtreatments/erythema-nodosum

  Erythema nodosum is a skin condition characterised by red and tender lumps, most commonly on the shins. […] The symptoms include: The skin on the shins is most commonly affected. Other areas that may be affected include the ankles, calves, thighs, buttocks and arms. Raised red, hard, hot and painful lumps appear on the skin. The lumps can be from 1 cm to 20 cm wide. Up to 50 lumps may develop in the affected area. Legs may swell. Fever and general malaise may occur. Around half of all cases are associated with joint pains, particularly the knees. Conjunctivitis sometimes develops. The lumps turn from bright cherry red to purple over a few days. The purple lumps become brownish-yellow and flat over a few weeks. The lumps tend to recur if the person doesn’t have sufficient rest. […] Even with treatment, the inflamed nodules can take around three to six weeks to resolve.

• #10 Erythema Nodosum Treatment Chandler Dermatologist

  https://chandlerdermatologist.com/medical-dermatology/erythema-nodosum/

  Erythema nodosum is a type of inflammation of the fat cells under the skin that causes tender red nodules or lumps, usually on the shins. It can be caused by various conditions, such as infections, drugs, autoimmune disorders, or pregnancy. […] The signs and symptoms of erythema nodosum are: Red, painful, and warm bumps on the skin, usually on the lower part of the legs. The bumps can also appear on other parts of the body, such as the thighs, arms, torso, and face. The bumps are about one-half inch to 4 inches in size and can range from two to 50 in number. The bumps start out red and then turn purple, looking like bruises as they heal. They also flatten out while healing. The bumps can last for two weeks and new bumps can keep forming for up to six weeks. Other symptoms may include fever, fatigue, joint pain, pain in the legs, ankle swelling, enlarged lymph nodes in the chest, cough, sore throat, weight loss, stomach pain, and diarrhea.

• #11 Disease – Erythema nodosum

  https://ssl.adam.com/content.aspx?productid=617&isarticlelink=false&pid=1&gid=000881&site=makatimed.adam.com&login=MAKA1603

  Erythema nodosum is most common on the front of the shins. It may also occur on other areas of the body such as buttocks, calves, ankles, thighs, and arms. […] The lesions begin as flat, firm, hot, red, painful lumps that are about 1 inch (2.5 centimeters) across. Within a few days, they may become purplish in color. Over several weeks, the lumps fade to a brownish, flat patch. […] Other symptoms may include: Fever, General ill feeling (malaise), Joint aches, Skin redness, inflammation, or irritation, Swelling of the leg or other affected area. […] Symptoms most often go away within about 6 weeks, but may return.

• #12 Erythema Nodosum Clinical Presentation: History, Physical Examination

  https://emedicine.medscape.com/article/1081633-clinical

  The eruptive phase of erythema nodosum (EN) begins with flulike symptoms of fever and generalized aching. Arthralgia may occur, appearing either before the eruption or during the eruptive phase. With infection-induced EN, most lesions heal within 7 weeks, though active disease may last as long as 18 weeks. In contrast, 30% of idiopathic EN cases may last longer than 6 months. Febrile illness with dermatologic findings includes abrupt onset of illness with initial fever, followed by a painful rash within 1-2 days. […] Lesions begin as red tender nodules. Their borders are poorly defined, and the range in size from 2 to 6 cm. During the first week, lesions become tense, hard, and painful; during the second week, they may become fluctuant, as in an abscess, but do not suppurate or ulcerate. Individual lesions last approximately 2 weeks, but occasionally, new lesions continue to appear for 3-6 weeks. Aching legs and swelling ankles may persist for weeks.

• #13 Erythema nodosum – Altmeyers Encyclopedia – Department Dermatology

  https://www.altmeyers.org/en/dermatology/erythema-nodosum-119277

  Acute, usually infection-related (frequently streptococcal infections), self-limiting panniculitis associated with general symptoms such as fever and arthralgias as well as subcutaneous, painful nodules (predominantly) on the extensor sides of the lower legs. […] Beginning with general symptoms such as fever, fatigue, tiredness, rheumatoid pain as well as symmetrically and bilaterally arranged, light or bright red, blurred, 2.0-10.0 cm in size, pressure pain, sometimes extremely pressure pain (so that even light touching is felt as unpleasant), doughy, slightly raised, reddish-livid lumps or plaques with a smooth, taut surface. The nodules never ulcerate. The single foci heal within 3-6 weeks with a change of colour (from reddish-brown to reddish-brown to brown-yellow and a slight grey-yellow) without scarring. […] Cheap. Spontaneous healing. Total duration: 3-6 weeks. Recurrence possible.

• #14 Erythema Nodosum: A Sign of Systemic Disease | AAFP

  https://www.aafp.org/pubs/afp/issues/2007/0301/p695.html

  Erythema nodosum, a painful disorder of the subcutaneous fat, is the most common type of panniculitis. The hallmark of erythema nodosum is tender, erythematous, subcutaneous nodules that typically are located symmetrically on the anterior surface of the lower extremities. Erythema nodosum tends to be self-limited. Painful, symmetric, red nodules Anterior legs most common location Involutes in weeks with bruise-like appearance Does not ulcerate; tends to heal completely. Initially, erythema nodosum nodules can be firm, but they usually become more fluctuant during the clinical evolution. Individual nodules may last for two weeks; new outcroppings may continue to arise for up to six weeks. These nodules often take approximately one to two months to heal completely and may assume a bruise-like appearance as they fade. A prodrome commonly occurs as early as one to three weeks before the onset of erythema nodosum, regardless of the etiology. Specific symptoms may include weight loss, malaise, low-grade fever, cough, and arthralgia with or without arthritis. Arthralgias have been known to persist for up to two years after the resolution of erythema nodosum. Erythema nodosum migrans, subacute nodular migratory panniculitis, and chronic erythema nodosum, disorders classically considered distinct from erythema nodosum, now are considered to be variants in the same disease spectrum.

• #15 Erythema nodosum – Cancer Therapy Advisor

  https://www.cancertherapyadvisor.com/home/decision-support-in-medicine/hospital-medicine/erythema-nodosum/

  The key features of erythema nodosum (EN) typically include sudden onset of bilateral, 1-5 cm tender, erythematous, subcutaneous nodules arising in crops, most commonly on the pretibial areas. […] After a few days, lesions may develop a brownish red or purple bruise-like appearance. The eruption usually lasts 3-6 weeks and lesions do not ulcerate or leave scars. Lesions may be accompanied by fever of 38-39 C, arthralgias, cough, diarrhea, and malaise. Joint pains may precede, coincide, or follow the eruption in as many as 90% of cases. […] EN has a much shorter duration in children, and fever is an accompanying manifestation in fewer than half of the cases. Although EN can be associated with a wide variety of systemic disorders, despite investigation, no underlying cause is found in most pediatric patients.

• #16 Disease – Erythema nodosum

  https://ssl.adam.com/content.aspx?productid=617&isarticlelink=false&pid=1&gid=000881&site=makatimed.adam.com&login=MAKA1603

  Erythema nodosum is most common on the front of the shins. It may also occur on other areas of the body such as buttocks, calves, ankles, thighs, and arms. […] The lesions begin as flat, firm, hot, red, painful lumps that are about 1 inch (2.5 centimeters) across. Within a few days, they may become purplish in color. Over several weeks, the lumps fade to a brownish, flat patch. […] Other symptoms may include: Fever, General ill feeling (malaise), Joint aches, Skin redness, inflammation, or irritation, Swelling of the leg or other affected area. […] Symptoms most often go away within about 6 weeks, but may return.

• #17 Erythema Nodosum – Skin Disorders – Merck Manual Consumer Version

  https://www.merckmanuals.com/home/skin-disorders/hypersensitivity-and-reactive-skin-disorders/erythema-nodosum

  Erythema nodosum is a form of panniculitis (inflammation of the fat layer beneath the skin) that produces tender red or violet bumps (nodules) under the skin, most often over the shins but occasionally on the arms and other areas. […] Typical symptoms include fever, joint pain, and characteristic painful red bumps and bruises on the person’s shins. […] Erythema nodosum nodules are tender and usually appear on the shins. They resemble raised bumps and bruises that gradually change from pink, to red or violet, to bluish brown. […] Fever and joint pain are common. […] Erythema nodosum almost always resolves on its own, and the nodules usually go away in 3 to 6 weeks without treatment.

• #18 Erythema nodosum: Causes, symptoms, and pictures

  https://www.medicalnewstoday.com/articles/320829

  Erythema nodosum (EN) symptoms can include painful bumps under the skin on the legs, fever, fatigue, and joint swelling. […] EN can develop suddenly without any warning signs. Some people experience non-specific symptoms before EN lesions develop. […] Many of the early signs of EN, especially joint pain, continue once the sores develop and may last for weeks to months after they have gone. […] Common early signs and symptoms of EN include: fever, unexplained exhaustion, lung, throat, or nose infections, joint and muscle pain and weakness, swollen joints, often the ankles and knees, conjunctivitis, cough, weight loss. […] The symptoms vary between individuals, but once EN lesions have developed, they normally have a few common characteristics. […] Most EN sores are usually: very painful, hot to touch, bright red for a week to 10 days then fade to purple or blue, on both sides of the body equally, on the front of the shins, but also sometimes the ankles, knees, thighs, and forearms, slightly raised, rounded in shape, non-ulcerating, or not causing breaks or tears in the surface of the skin, varying in size from a grape to a grapefruit, but mostly between 1 centimeter (cm) and 5 cm, varying in number, from 2 to more than 50, shiny in appearance.

• #19 Erythema nodosum – Wikipedia

  https://en.wikipedia.org/wiki/Erythema_nodosum

  Erythema nodosum is an inflammatory condition characterized by inflammation of subcutaneous fat tissue, resulting in painful red/blue lumps or nodules that are usually seen symmetrically on both shins, on the thighs, arms, and elsewhere. It typically resolves spontaneously within 30 days. It is common in young people aged 12-20 years. […] The first signs of erythema nodosum are often flu-like symptoms such as a fever, cough, malaise, and aching joints. Some people also experience stiffness or swelling in the joints and weight loss. […] Erythema nodosum is characterised by 1-2 inch (25-51 mm) nodules (rounded lumps) below the skin surface, usually on the shins. These subcutaneous nodules can appear anywhere on the body, but the most common sites are the shins, arms, thighs, and torso. Each nodule typically disappears after around two weeks, though new ones may continue to form for up to six or eight weeks. A new nodule usually appears red and is hot and firm to the touch. The redness starts to fade and it gradually becomes softer and smaller until it disappears. Each nodule usually heals completely without scarring over the course of about two weeks. Joint pain and inflammation sometimes continue for several weeks or months after the nodules appear. […] Erythema nodosum is self-limiting and usually resolves itself within 3-6 weeks. A recurring form does exist, and in children, it is attributed to repeated infections with streptococcus.

• #20 Erythema Nodosum | Cedars-Sinai

  https://www.cedars-sinai.org/health-library/diseases-and-conditions/e/erythema-nodosum.html

  Erythema nodosum is a skin condition of the fat just below your skin (the subcutaneous layer). Its often a reaction to an infection or medicine. But it may occur for no known reason. It causes tender, red bumps to form, usually on the shins. The bumps may also appear on other parts of the body, such as the ankles, thighs, arms, or face. […] Erythema nodosum is usually not a serious condition. Symptoms often go away within 6 weeks. But they may appear again. As the bumps fade, they may look like bruises. […] These are the most common symptoms of erythema nodosum: Red, sore bumps on the shins, Fever, Fatigue, Joint pain or swelling, Enlarged lymph nodes in the chest. […] Along with the bumps, symptoms include fever and joint pain.

• #21 Erythema nodosum: Causes, symptoms, and pictures

  https://www.medicalnewstoday.com/articles/320829

  Erythema nodosum (EN) symptoms can include painful bumps under the skin on the legs, fever, fatigue, and joint swelling. […] EN can develop suddenly without any warning signs. Some people experience non-specific symptoms before EN lesions develop. […] Many of the early signs of EN, especially joint pain, continue once the sores develop and may last for weeks to months after they have gone. […] Common early signs and symptoms of EN include: fever, unexplained exhaustion, lung, throat, or nose infections, joint and muscle pain and weakness, swollen joints, often the ankles and knees, conjunctivitis, cough, weight loss. […] The symptoms vary between individuals, but once EN lesions have developed, they normally have a few common characteristics. […] Most EN sores are usually: very painful, hot to touch, bright red for a week to 10 days then fade to purple or blue, on both sides of the body equally, on the front of the shins, but also sometimes the ankles, knees, thighs, and forearms, slightly raised, rounded in shape, non-ulcerating, or not causing breaks or tears in the surface of the skin, varying in size from a grape to a grapefruit, but mostly between 1 centimeter (cm) and 5 cm, varying in number, from 2 to more than 50, shiny in appearance.

• #22 Erythema Nodosum Clinical Presentation: History, Physical Examination

  https://emedicine.medscape.com/article/1081633-clinical

  The eruptive phase of erythema nodosum (EN) begins with flulike symptoms of fever and generalized aching. Arthralgia may occur, appearing either before the eruption or during the eruptive phase. With infection-induced EN, most lesions heal within 7 weeks, though active disease may last as long as 18 weeks. In contrast, 30% of idiopathic EN cases may last longer than 6 months. Febrile illness with dermatologic findings includes abrupt onset of illness with initial fever, followed by a painful rash within 1-2 days. […] Lesions begin as red tender nodules. Their borders are poorly defined, and the range in size from 2 to 6 cm. During the first week, lesions become tense, hard, and painful; during the second week, they may become fluctuant, as in an abscess, but do not suppurate or ulcerate. Individual lesions last approximately 2 weeks, but occasionally, new lesions continue to appear for 3-6 weeks. Aching legs and swelling ankles may persist for weeks.

• #23 Erythema Nodosum | Doctor

  https://patient.info/doctor/erythema-nodosum-pro

  When the aetiology is an infection the lesions usually heal in six to eight weeks but 30% of idiopathic cases last six months. Arthralgia occurs in more than half of patients and begins either during the eruptive phase or two to four weeks before. Joints are red, swollen and tender, sometimes with effusions. Morning stiffness may occur. The ankles, knees and wrists are most often involved. Synovitis resolves in a few weeks but joint pain and stiffness may last up to six months. There are no destructive changes in the joint and synovial fluid is acellular and the rheumatoid factor is negative. […] Erythema nodosum usually resolves within six weeks but it may be more protracted, especially if the underlying cause of erythema nodosum remains or when it is idiopathic. Serious complications are unusual unless part of the underlying disease. Chronic or recurrent disease is rare. Lesions heal without atrophy or scarring.

• #24 Erythema Nodosum Clinical Presentation: History, Physical Examination

  https://emedicine.medscape.com/article/1081633-clinical

  Characteristically, lesions appear on the anterior leg; however, they may appear on any surface. In the second week, they change color from bright red to bluish or livid. As absorption progresses, the color gradually fades to a yellowish hue, resembling a bruise. This disappears in 1-2 weeks as the overlying skin desquamates. […] Arthralgia occurs in more than 50% of patients and, as noted, may begin either during the eruptive phase or 2-4 weeks before the eruption. Erythema, swelling, and tenderness occur over the joint, sometimes with effusions. Joint tenderness and morning stiffness may occur. Any joint may be involved, but the ankles, knees, and wrist are affected most commonly. Although synovitis resolves within a few weeks, joint pain and stiffness may last as long as 6 months. No destructive joint changes occur. Synovial fluid is acellular, and rheumatoid factor is negative.

• #25 Erythema Nodosum Clinical Presentation: History, Physical Examination

  https://emedicine.medscape.com/article/1081633-clinical

  Characteristically, lesions appear on the anterior leg; however, they may appear on any surface. In the second week, they change color from bright red to bluish or livid. As absorption progresses, the color gradually fades to a yellowish hue, resembling a bruise. This disappears in 1-2 weeks as the overlying skin desquamates. […] Arthralgia occurs in more than 50% of patients and, as noted, may begin either during the eruptive phase or 2-4 weeks before the eruption. Erythema, swelling, and tenderness occur over the joint, sometimes with effusions. Joint tenderness and morning stiffness may occur. Any joint may be involved, but the ankles, knees, and wrist are affected most commonly. Although synovitis resolves within a few weeks, joint pain and stiffness may last as long as 6 months. No destructive joint changes occur. Synovial fluid is acellular, and rheumatoid factor is negative.

• #26 Erythema Nodosum | Doctor

  https://patient.info/doctor/erythema-nodosum-pro

  When the aetiology is an infection the lesions usually heal in six to eight weeks but 30% of idiopathic cases last six months. Arthralgia occurs in more than half of patients and begins either during the eruptive phase or two to four weeks before. Joints are red, swollen and tender, sometimes with effusions. Morning stiffness may occur. The ankles, knees and wrists are most often involved. Synovitis resolves in a few weeks but joint pain and stiffness may last up to six months. There are no destructive changes in the joint and synovial fluid is acellular and the rheumatoid factor is negative. […] Erythema nodosum usually resolves within six weeks but it may be more protracted, especially if the underlying cause of erythema nodosum remains or when it is idiopathic. Serious complications are unusual unless part of the underlying disease. Chronic or recurrent disease is rare. Lesions heal without atrophy or scarring.

• #27 Erythema Nodosum | Loma Linda University Health

  https://lluh.org/conditions/erythema-nodosum

  Erythema nodosum is a skin condition of the fat that lies just below your skin (the subcutaneous layer). It causes tender, red bumps to form, usually on the shins that may become purplish in color within a few days. The bumps may also appear on other parts of the body, such as the ankles, thighs, arms, or face. […] Erythema nodosum is usually not a serious condition. Symptoms often go away within 6 weeks. But they may appear again. As the bumps fade, they may look like bruises. […] These are the most common symptoms of erythema nodosum: Red, sore bumps on the shins that may become purplish in color within a few days, Fever, Fatigue, Joint pain or swelling, Enlarged lymph nodes in the chest. […] Erythema nodosum is a skin condition. It causes tender, red bumps, which may become purplish in color within a few days. They usually develop on the shins. […] Along with the bumps, symptoms include fever and joint pain.

• #28 Erythema Nodosum Clinical Presentation: History, Physical Examination

  https://emedicine.medscape.com/article/1081633-clinical

  Characteristically, lesions appear on the anterior leg; however, they may appear on any surface. In the second week, they change color from bright red to bluish or livid. As absorption progresses, the color gradually fades to a yellowish hue, resembling a bruise. This disappears in 1-2 weeks as the overlying skin desquamates. […] Arthralgia occurs in more than 50% of patients and, as noted, may begin either during the eruptive phase or 2-4 weeks before the eruption. Erythema, swelling, and tenderness occur over the joint, sometimes with effusions. Joint tenderness and morning stiffness may occur. Any joint may be involved, but the ankles, knees, and wrist are affected most commonly. Although synovitis resolves within a few weeks, joint pain and stiffness may last as long as 6 months. No destructive joint changes occur. Synovial fluid is acellular, and rheumatoid factor is negative.

• #29 Erythema Nodosum | Doctor

  https://patient.info/doctor/erythema-nodosum-pro

  When the aetiology is an infection the lesions usually heal in six to eight weeks but 30% of idiopathic cases last six months. Arthralgia occurs in more than half of patients and begins either during the eruptive phase or two to four weeks before. Joints are red, swollen and tender, sometimes with effusions. Morning stiffness may occur. The ankles, knees and wrists are most often involved. Synovitis resolves in a few weeks but joint pain and stiffness may last up to six months. There are no destructive changes in the joint and synovial fluid is acellular and the rheumatoid factor is negative. […] Erythema nodosum usually resolves within six weeks but it may be more protracted, especially if the underlying cause of erythema nodosum remains or when it is idiopathic. Serious complications are unusual unless part of the underlying disease. Chronic or recurrent disease is rare. Lesions heal without atrophy or scarring.

• #30 Erythema Nodosum | Doctor

  https://patient.info/doctor/erythema-nodosum-pro

  When the aetiology is an infection the lesions usually heal in six to eight weeks but 30% of idiopathic cases last six months. Arthralgia occurs in more than half of patients and begins either during the eruptive phase or two to four weeks before. Joints are red, swollen and tender, sometimes with effusions. Morning stiffness may occur. The ankles, knees and wrists are most often involved. Synovitis resolves in a few weeks but joint pain and stiffness may last up to six months. There are no destructive changes in the joint and synovial fluid is acellular and the rheumatoid factor is negative. […] Erythema nodosum usually resolves within six weeks but it may be more protracted, especially if the underlying cause of erythema nodosum remains or when it is idiopathic. Serious complications are unusual unless part of the underlying disease. Chronic or recurrent disease is rare. Lesions heal without atrophy or scarring.

• #31 Erythema Nodosum Clinical Presentation: History, Physical Examination

  https://emedicine.medscape.com/article/1081633-clinical

  Characteristically, lesions appear on the anterior leg; however, they may appear on any surface. In the second week, they change color from bright red to bluish or livid. As absorption progresses, the color gradually fades to a yellowish hue, resembling a bruise. This disappears in 1-2 weeks as the overlying skin desquamates. […] Arthralgia occurs in more than 50% of patients and, as noted, may begin either during the eruptive phase or 2-4 weeks before the eruption. Erythema, swelling, and tenderness occur over the joint, sometimes with effusions. Joint tenderness and morning stiffness may occur. Any joint may be involved, but the ankles, knees, and wrist are affected most commonly. Although synovitis resolves within a few weeks, joint pain and stiffness may last as long as 6 months. No destructive joint changes occur. Synovial fluid is acellular, and rheumatoid factor is negative.

• #32 Erythema Nodosum – StatPearls – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK470369/

  Erythema nodosum (EN) is a common acute nodular septal panniculitis, characterized by the sudden onset of erythematous, firm, solid, deep nodules or plaques that are painful on palpation and mainly localized on extensor surfaces of the legs. […] Erythema nodosum is characterized in a rather stereotyped way, whatever its cause, by the following evolutionary aspects: […] The general syndrome occurs with fever, and arthralgia of the prodromal phase persists or increases. […] Nodules appear on the extensor surfaces of the legs and knees, and sometimes thighs and forearms. […] Each nodule evolves in ten days, taking blue and yellowish contusiform aspects towards complete disappearance without sequelae. […] EN never involves necrosis, ulceration, or scarring. […] The prognosis for patients with EN is good but there is a small risk of recurrence. The skin lesions often take months to resolve but there is usually no scarring or pigmentation change.

• #33 Erythema Nodosum Clinical Presentation: History, Physical Examination

  https://emedicine.medscape.com/article/1081633-clinical

  The eruptive phase of erythema nodosum (EN) begins with flulike symptoms of fever and generalized aching. Arthralgia may occur, appearing either before the eruption or during the eruptive phase. With infection-induced EN, most lesions heal within 7 weeks, though active disease may last as long as 18 weeks. In contrast, 30% of idiopathic EN cases may last longer than 6 months. Febrile illness with dermatologic findings includes abrupt onset of illness with initial fever, followed by a painful rash within 1-2 days. […] Lesions begin as red tender nodules. Their borders are poorly defined, and the range in size from 2 to 6 cm. During the first week, lesions become tense, hard, and painful; during the second week, they may become fluctuant, as in an abscess, but do not suppurate or ulcerate. Individual lesions last approximately 2 weeks, but occasionally, new lesions continue to appear for 3-6 weeks. Aching legs and swelling ankles may persist for weeks.

• #34 Erythema Nodosum | Doctor

  https://patient.info/doctor/erythema-nodosum-pro

  Erythema nodosum symptoms […] The eruptive phase of erythema nodosum begins with fever, aching and arthralgia, accompanied by a painful rash. Lesions begin as red, tender nodules. The borders are poorly defined and they are 2-6 cms in diameter. In the first week of having erythema nodosum the lesions become tense, hard and painful. In the second week, they may become fluctuant, rather like an abscess but they do not suppurate or ulcerate. Individual lesions last around two weeks but occasionally, new lesions continue to appear for three to six weeks. Aching legs and swollen ankles may persist for many weeks. In the first week they are bright red but in the second week there is a blue or purple hue, even turning yellow like a resolving bruise before disappearing in a couple of weeks. They can occur anywhere but are usually on the anterior aspect of the lower leg.

• #35 Erythema Nodosum | Doctor

  https://patient.info/doctor/erythema-nodosum-pro

  Erythema nodosum symptoms […] The eruptive phase of erythema nodosum begins with fever, aching and arthralgia, accompanied by a painful rash. Lesions begin as red, tender nodules. The borders are poorly defined and they are 2-6 cms in diameter. In the first week of having erythema nodosum the lesions become tense, hard and painful. In the second week, they may become fluctuant, rather like an abscess but they do not suppurate or ulcerate. Individual lesions last around two weeks but occasionally, new lesions continue to appear for three to six weeks. Aching legs and swollen ankles may persist for many weeks. In the first week they are bright red but in the second week there is a blue or purple hue, even turning yellow like a resolving bruise before disappearing in a couple of weeks. They can occur anywhere but are usually on the anterior aspect of the lower leg.

• #36 Erythema Nodosum – StatPearls – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK470369/

  Erythema nodosum (EN) is a common acute nodular septal panniculitis, characterized by the sudden onset of erythematous, firm, solid, deep nodules or plaques that are painful on palpation and mainly localized on extensor surfaces of the legs. […] Erythema nodosum is characterized in a rather stereotyped way, whatever its cause, by the following evolutionary aspects: […] The general syndrome occurs with fever, and arthralgia of the prodromal phase persists or increases. […] Nodules appear on the extensor surfaces of the legs and knees, and sometimes thighs and forearms. […] Each nodule evolves in ten days, taking blue and yellowish contusiform aspects towards complete disappearance without sequelae. […] EN never involves necrosis, ulceration, or scarring. […] The prognosis for patients with EN is good but there is a small risk of recurrence. The skin lesions often take months to resolve but there is usually no scarring or pigmentation change.

• #37 Erythema Nodosum | Doctor

  https://patient.info/doctor/erythema-nodosum-pro

  Erythema nodosum symptoms […] The eruptive phase of erythema nodosum begins with fever, aching and arthralgia, accompanied by a painful rash. Lesions begin as red, tender nodules. The borders are poorly defined and they are 2-6 cms in diameter. In the first week of having erythema nodosum the lesions become tense, hard and painful. In the second week, they may become fluctuant, rather like an abscess but they do not suppurate or ulcerate. Individual lesions last around two weeks but occasionally, new lesions continue to appear for three to six weeks. Aching legs and swollen ankles may persist for many weeks. In the first week they are bright red but in the second week there is a blue or purple hue, even turning yellow like a resolving bruise before disappearing in a couple of weeks. They can occur anywhere but are usually on the anterior aspect of the lower leg.

• #38 Erythema Nodosum | Doctor

  https://patient.info/doctor/erythema-nodosum-pro

  Erythema nodosum symptoms […] The eruptive phase of erythema nodosum begins with fever, aching and arthralgia, accompanied by a painful rash. Lesions begin as red, tender nodules. The borders are poorly defined and they are 2-6 cms in diameter. In the first week of having erythema nodosum the lesions become tense, hard and painful. In the second week, they may become fluctuant, rather like an abscess but they do not suppurate or ulcerate. Individual lesions last around two weeks but occasionally, new lesions continue to appear for three to six weeks. Aching legs and swollen ankles may persist for many weeks. In the first week they are bright red but in the second week there is a blue or purple hue, even turning yellow like a resolving bruise before disappearing in a couple of weeks. They can occur anywhere but are usually on the anterior aspect of the lower leg.

• #39 Erythema nodosum – Cancer Therapy Advisor

  https://www.cancertherapyadvisor.com/home/decision-support-in-medicine/hospital-medicine/erythema-nodosum/

  A clinical clue to the diagnosis is the predictable change in color over time from red to purple to yellow-green, resulting in bruise-like changes. […] EN tends to resolve spontaneously over 3-4 weeks and the course is generally benign. More severe cases resolve over 6 weeks. Lesions heal without scarring, atrophy, or ulceration. Recrudescences may appear over a period of weeks to months, but attacks are seldom recurrent. In 10% of patients who have recurring disease, these recurrences are frequently associated with repeated streptococcal infection.

• #40 Erythema Nodosum Clinical Presentation: History, Physical Examination

  https://emedicine.medscape.com/article/1081633-clinical

  The eruptive phase of erythema nodosum (EN) begins with flulike symptoms of fever and generalized aching. Arthralgia may occur, appearing either before the eruption or during the eruptive phase. With infection-induced EN, most lesions heal within 7 weeks, though active disease may last as long as 18 weeks. In contrast, 30% of idiopathic EN cases may last longer than 6 months. Febrile illness with dermatologic findings includes abrupt onset of illness with initial fever, followed by a painful rash within 1-2 days. […] Lesions begin as red tender nodules. Their borders are poorly defined, and the range in size from 2 to 6 cm. During the first week, lesions become tense, hard, and painful; during the second week, they may become fluctuant, as in an abscess, but do not suppurate or ulcerate. Individual lesions last approximately 2 weeks, but occasionally, new lesions continue to appear for 3-6 weeks. Aching legs and swelling ankles may persist for weeks.

• #41 Erythema nodosum – Symptoms, diagnosis and treatment | BMJ Best Practice US

  https://bestpractice.bmj.com/topics/en-us/332

  Erythema nodosum presents with tender, nonulcerated, erythematous nodules located most commonly over the shins, and may sometimes be associated with arthralgia and fever. […] Lesions arise as single or clustered, tender patches, later evolving into painful nodules over the course of several days. Occasionally these nodules are associated with extravasated blood, resulting in the appearance of purpura. These ecchymotic areas fade into variably pigmented patches before resolving. […] As new crops of nodules may form weeks after the initial presentation, lesions at varying stages of resolution may coexist.

• #42 Erythema nodosum

  https://www.nhs.uk/conditions/erythema-nodosum/

  Erythema nodosum is a condition that causes painful patches of skin that look red or darker than the surrounding skin. It usually goes away by itself, but it can sometimes be a sign of something serious like an inflammatory bowel condition, such as Crohn’s disease. […] If you have erythema nodosum, you may have flu-like symptoms before or at the same time as you get the patches on your skin. […] The skin usually heals on its own within 3 to 8 weeks without leaving a scar. But other symptoms, such as joint pain and swelling, can last for several weeks. […] If your symptoms have lasted a long time or they keep returning, other treatments, such as steroid tablets, may be recommended.

• #43 Erythema Nodosum Clinical Presentation: History, Physical Examination

  https://emedicine.medscape.com/article/1081633-clinical

  Characteristically, lesions appear on the anterior leg; however, they may appear on any surface. In the second week, they change color from bright red to bluish or livid. As absorption progresses, the color gradually fades to a yellowish hue, resembling a bruise. This disappears in 1-2 weeks as the overlying skin desquamates. […] Arthralgia occurs in more than 50% of patients and, as noted, may begin either during the eruptive phase or 2-4 weeks before the eruption. Erythema, swelling, and tenderness occur over the joint, sometimes with effusions. Joint tenderness and morning stiffness may occur. Any joint may be involved, but the ankles, knees, and wrist are affected most commonly. Although synovitis resolves within a few weeks, joint pain and stiffness may last as long as 6 months. No destructive joint changes occur. Synovial fluid is acellular, and rheumatoid factor is negative.

• #44 Erythema Nodosum: Causes, Symptoms, and Treatment

  https://patient.info/skin-conditions/erythema-nodosum

  Erythema nodosum is a condition that causes red rounded lumps (nodules) to form just below the skin surface, most commonly on the shins. […] Usually, the nodules heal within six to eight weeks with no treatment needed. […] Before the rounded lumps (nodules) appear, you may feel generally unwell for a few weeks. You may have a high temperature (fever), a cough and may lose weight during this time. You may also have aching joints, stiffness and general aches and pains. Your joints may become swollen. […] Each nodule tends to last for about two weeks but new nodules can continue to appear for up to six weeks. […] It usually takes some weeks for the nodules to heal completely. They do not leave any scarring. […] For most people with erythema nodosum the rounded lumps (nodules) tend to resolve spontaneously and heal with no scarring, within six weeks. However, in some people with idiopathic erythema nodosum, nodules may last for up to six months or more. […] Generally, the outlook for erythema nodosum is very good and most people do not have further problems. Persistent (chronic) or repeated (recurrent) erythema nodosum can occur in some people but this is rare.

• #45 Erythema Nodosum | Doctor

  https://patient.info/doctor/erythema-nodosum-pro

  When the aetiology is an infection the lesions usually heal in six to eight weeks but 30% of idiopathic cases last six months. Arthralgia occurs in more than half of patients and begins either during the eruptive phase or two to four weeks before. Joints are red, swollen and tender, sometimes with effusions. Morning stiffness may occur. The ankles, knees and wrists are most often involved. Synovitis resolves in a few weeks but joint pain and stiffness may last up to six months. There are no destructive changes in the joint and synovial fluid is acellular and the rheumatoid factor is negative. […] Erythema nodosum usually resolves within six weeks but it may be more protracted, especially if the underlying cause of erythema nodosum remains or when it is idiopathic. Serious complications are unusual unless part of the underlying disease. Chronic or recurrent disease is rare. Lesions heal without atrophy or scarring.

• #46 Erythema Nodosum: Symptoms, Causes, Diagnosis, and Treatment

  https://www.webmd.com/skin-problems-and-treatments/erythema-nodosum

  The tender lumps, also called nodules, of erythema nodosum usually form on both your shins. Sometimes, though, the nodules may appear anywhere on your arms, chest, stomach, butt, back, or legs. On light skin tones, the nodules may look red or purple. […] On dark skin tones, they may look dusky purple, gray, or black, or your skin could take on a different texture. For instance, your skin may peel or you may get pimple-like bumps. […] The nodules can be as big around as a penny or a lime. They may be tender and swollen off and on for a few weeks. They can take 1-2 months to heal all the way, and they may look like bruises as they fade to your natural skin tone. They usually don’t leave scars, but sometimes you may get a little pit in your skin where your fat layer has been injured. […] Symptoms of erythema nodosum include: Lumps under your skin that may be warm and tender and look like a bruise, Low-grade fever, Feeling sick (malaise), Fatigue, Swollen lymph nodes, Cough, Joint pain, especially in your ankles and knees, Weight loss, Stomach pain, vomiting, or diarrhea. […] Rarely, you may have another form called chronic erythema nodosum. In this form, the lumps may join to make large, raised patches on your skin, but these patches tend to be less tender than the nodules.

• #47 Erythema nodosum

  https://www.nhs.uk/conditions/erythema-nodosum/

  Erythema nodosum is a condition that causes painful patches of skin that look red or darker than the surrounding skin. It usually goes away by itself, but it can sometimes be a sign of something serious like an inflammatory bowel condition, such as Crohn’s disease. […] If you have erythema nodosum, you may have flu-like symptoms before or at the same time as you get the patches on your skin. […] The skin usually heals on its own within 3 to 8 weeks without leaving a scar. But other symptoms, such as joint pain and swelling, can last for several weeks. […] If your symptoms have lasted a long time or they keep returning, other treatments, such as steroid tablets, may be recommended.

• #48 Erythema nodosum – Wikipedia

  https://en.wikipedia.org/wiki/Erythema_nodosum

  Erythema nodosum is an inflammatory condition characterized by inflammation of subcutaneous fat tissue, resulting in painful red/blue lumps or nodules that are usually seen symmetrically on both shins, on the thighs, arms, and elsewhere. It typically resolves spontaneously within 30 days. It is common in young people aged 12-20 years. […] The first signs of erythema nodosum are often flu-like symptoms such as a fever, cough, malaise, and aching joints. Some people also experience stiffness or swelling in the joints and weight loss. […] Erythema nodosum is characterised by 1-2 inch (25-51 mm) nodules (rounded lumps) below the skin surface, usually on the shins. These subcutaneous nodules can appear anywhere on the body, but the most common sites are the shins, arms, thighs, and torso. Each nodule typically disappears after around two weeks, though new ones may continue to form for up to six or eight weeks. A new nodule usually appears red and is hot and firm to the touch. The redness starts to fade and it gradually becomes softer and smaller until it disappears. Each nodule usually heals completely without scarring over the course of about two weeks. Joint pain and inflammation sometimes continue for several weeks or months after the nodules appear. […] Erythema nodosum is self-limiting and usually resolves itself within 3-6 weeks. A recurring form does exist, and in children, it is attributed to repeated infections with streptococcus.

• #49 Erythema Nodosum Clinical Presentation: History, Physical Examination

  https://emedicine.medscape.com/article/1081633-clinical

  The eruptive phase of erythema nodosum (EN) begins with flulike symptoms of fever and generalized aching. Arthralgia may occur, appearing either before the eruption or during the eruptive phase. With infection-induced EN, most lesions heal within 7 weeks, though active disease may last as long as 18 weeks. In contrast, 30% of idiopathic EN cases may last longer than 6 months. Febrile illness with dermatologic findings includes abrupt onset of illness with initial fever, followed by a painful rash within 1-2 days. […] Lesions begin as red tender nodules. Their borders are poorly defined, and the range in size from 2 to 6 cm. During the first week, lesions become tense, hard, and painful; during the second week, they may become fluctuant, as in an abscess, but do not suppurate or ulcerate. Individual lesions last approximately 2 weeks, but occasionally, new lesions continue to appear for 3-6 weeks. Aching legs and swelling ankles may persist for weeks.

• #50 Erythema Nodosum | Doctor

  https://patient.info/doctor/erythema-nodosum-pro

  When the aetiology is an infection the lesions usually heal in six to eight weeks but 30% of idiopathic cases last six months. Arthralgia occurs in more than half of patients and begins either during the eruptive phase or two to four weeks before. Joints are red, swollen and tender, sometimes with effusions. Morning stiffness may occur. The ankles, knees and wrists are most often involved. Synovitis resolves in a few weeks but joint pain and stiffness may last up to six months. There are no destructive changes in the joint and synovial fluid is acellular and the rheumatoid factor is negative. […] Erythema nodosum usually resolves within six weeks but it may be more protracted, especially if the underlying cause of erythema nodosum remains or when it is idiopathic. Serious complications are unusual unless part of the underlying disease. Chronic or recurrent disease is rare. Lesions heal without atrophy or scarring.

• #51 Erythema nodosum: Symptoms, Causes, and Management — DermNet

  https://dermnetnz.org/topics/erythema-nodosum

  Erythema nodosum presents with tender bilateral erythematous subcutaneous nodules 320 cm in diameter erupting over one to several weeks. They are accompanied by fever and joint pain. In 50% the ankle is swollen and painful for up to several weeks. The knees and other joints can also be affected. […] Erythema nodosum follows a relatively benign and favourable course. It is important to recognise the underlying cause, if any, and initiate symptomatic treatment. Most cases resolve within days to weeks. Relapses may occur in approximately one-third of cases erythema nodosum may become a chronic or persistent disorder lasting for 6 months and occasionally for years.

• #52 Erythema Nodosum: Symptoms, Causes, Diagnosis, and Treatment

  https://www.webmd.com/skin-problems-and-treatments/erythema-nodosum

  The tender lumps, also called nodules, of erythema nodosum usually form on both your shins. Sometimes, though, the nodules may appear anywhere on your arms, chest, stomach, butt, back, or legs. On light skin tones, the nodules may look red or purple. […] On dark skin tones, they may look dusky purple, gray, or black, or your skin could take on a different texture. For instance, your skin may peel or you may get pimple-like bumps. […] The nodules can be as big around as a penny or a lime. They may be tender and swollen off and on for a few weeks. They can take 1-2 months to heal all the way, and they may look like bruises as they fade to your natural skin tone. They usually don’t leave scars, but sometimes you may get a little pit in your skin where your fat layer has been injured. […] Symptoms of erythema nodosum include: Lumps under your skin that may be warm and tender and look like a bruise, Low-grade fever, Feeling sick (malaise), Fatigue, Swollen lymph nodes, Cough, Joint pain, especially in your ankles and knees, Weight loss, Stomach pain, vomiting, or diarrhea. […] Rarely, you may have another form called chronic erythema nodosum. In this form, the lumps may join to make large, raised patches on your skin, but these patches tend to be less tender than the nodules.

• #53 Erythema nodosum – BAD Patient Hub

  https://www.skinhealthinfo.org.uk/condition/erythema-nodosum/

  Erythema nodosum (EN) is a skin condition that is characterised by painful red, round lumps which typically appear on the shins and around the ankles, and less commonly the thighs and forearms. […] Patients with EN may feel generally unwell with a temperature shortly before or at the same time as the lumps start to appear. There may also be aching and swelling of the joints, mainly knees, ankles and wrists. Aching of the legs and swelling of the ankles may last for several weeks after the lumps have appeared. […] EN starts as poorly defined red painful lumps. They feel like firm, smooth, raised lumps, 2 to 6 cm in diameter on the skin and are often very tender. They most typically appear on the shins and around the ankles, however less commonly on the arms, thigh and neck. As the lump begins to fade, it looks more like a bruise. The lumps usually clear over a period of 36 weeks without scarring. […] Most patients with EN make a full recovery within a few weeks or months. Relapses may occur in approximately one third of cases with the condition persisting and becoming a chronic disorder lasting for 6 months or even years.

• #54 Erythema Nodosum: Symptoms, Causes & Treatment

  https://my.clevelandclinic.org/health/diseases/24565-erythema-nodosum

  Erythema nodosum can resolve on its own after a few weeks to months and doesn’t always need treatment. […] After treatment begins, you could see your symptoms of pain and swelling reduce. The bumps (nodules) and visible signs of the condition will still be on your skin for several weeks to months. During this time, your skin might change color, from red and purple to brown, before returning to your natural skin color. This is normal. […] Erythema nodosum can return throughout your life after it goes away. If you manage or treat the underlying condition that caused your symptoms or you stop taking medicine that caused your symptoms, you reduce your risk of having an erythema nodosum flare.

• #55 Erythema nodosum – Cancer Therapy Advisor

  https://www.cancertherapyadvisor.com/home/decision-support-in-medicine/hospital-medicine/erythema-nodosum/

  A clinical clue to the diagnosis is the predictable change in color over time from red to purple to yellow-green, resulting in bruise-like changes. […] EN tends to resolve spontaneously over 3-4 weeks and the course is generally benign. More severe cases resolve over 6 weeks. Lesions heal without scarring, atrophy, or ulceration. Recrudescences may appear over a period of weeks to months, but attacks are seldom recurrent. In 10% of patients who have recurring disease, these recurrences are frequently associated with repeated streptococcal infection.

• #56 Erythema Nodosum: A Sign of Systemic Disease | AAFP

  https://www.aafp.org/pubs/afp/issues/2007/0301/p695.html

  Erythema nodosum, a painful disorder of the subcutaneous fat, is the most common type of panniculitis. The hallmark of erythema nodosum is tender, erythematous, subcutaneous nodules that typically are located symmetrically on the anterior surface of the lower extremities. Erythema nodosum tends to be self-limited. Painful, symmetric, red nodules Anterior legs most common location Involutes in weeks with bruise-like appearance Does not ulcerate; tends to heal completely. Initially, erythema nodosum nodules can be firm, but they usually become more fluctuant during the clinical evolution. Individual nodules may last for two weeks; new outcroppings may continue to arise for up to six weeks. These nodules often take approximately one to two months to heal completely and may assume a bruise-like appearance as they fade. A prodrome commonly occurs as early as one to three weeks before the onset of erythema nodosum, regardless of the etiology. Specific symptoms may include weight loss, malaise, low-grade fever, cough, and arthralgia with or without arthritis. Arthralgias have been known to persist for up to two years after the resolution of erythema nodosum. Erythema nodosum migrans, subacute nodular migratory panniculitis, and chronic erythema nodosum, disorders classically considered distinct from erythema nodosum, now are considered to be variants in the same disease spectrum.

• #57 Erythema Nodosum: Symptoms, Causes & Treatment

  https://my.clevelandclinic.org/health/diseases/24565-erythema-nodosum

  Erythema nodosum causes red to purple, painful bumps to form on your skin. These bumps can form anywhere on your body, but most often affect the front of your shins. The bumps can resolve on their own within weeks to months. […] Erythema nodosum causes bumps to form on your skin. These bumps can be tender, painful and warm to the touch, which can make the affected area of your skin feel uncomfortable. You might notice your skin change color from a red to a purple or brown as your skin heals before it returns to your natural skin tone. […] Symptoms of erythema nodosum range in severity for each person and could include: Bumps (nodules) on your skin. The bumps are warm to the touch and red to purple, similar to a bruise. Bumps are tender and painful. Bumps fade into a flat, purple to brown patch after several weeks.

• #58 Erythema nodosum symptoms, treatments & forums | PatientsLikeMe

  https://www.patientslikeme.com/conditions/erythema-nodosum

  Erythema nodosum is a skin disorder characterized by tender, swelling, red nodules under the skin. The area starts out slightly raised and bright red and then turns to a purplish red, as they start to fade they turn yellow. The cause is usually linked to medications, infections, or other conditions. […] Common symptom Pain […] 14 erythema nodosum patients report severe pain (32%) […] 15 erythema nodosum patients report moderate pain (34%) […] 6 erythema nodosum patients report mild pain (13%) […] 8 erythema nodosum patients report no pain (18%). […] Common symptom Fatigue […] 14 erythema nodosum patients report severe fatigue (31%) […] 19 erythema nodosum patients report moderate fatigue (43%) […] 5 erythema nodosum patients report mild fatigue (11%) […] 6 erythema nodosum patients report no fatigue (13%).

• #59 Erythema nodosum symptoms, treatments & forums | PatientsLikeMe

  https://www.patientslikeme.com/conditions/erythema-nodosum

  Erythema nodosum is a skin disorder characterized by tender, swelling, red nodules under the skin. The area starts out slightly raised and bright red and then turns to a purplish red, as they start to fade they turn yellow. The cause is usually linked to medications, infections, or other conditions. […] Common symptom Pain […] 14 erythema nodosum patients report severe pain (32%) […] 15 erythema nodosum patients report moderate pain (34%) […] 6 erythema nodosum patients report mild pain (13%) […] 8 erythema nodosum patients report no pain (18%). […] Common symptom Fatigue […] 14 erythema nodosum patients report severe fatigue (31%) […] 19 erythema nodosum patients report moderate fatigue (43%) […] 5 erythema nodosum patients report mild fatigue (11%) […] 6 erythema nodosum patients report no fatigue (13%).

• #60 Erythema nodosum symptoms, treatments & forums | PatientsLikeMe

  https://www.patientslikeme.com/conditions/erythema-nodosum

  Common symptom Stress […] 3 erythema nodosum patients report severe stress (23%) […] 6 erythema nodosum patients report moderate stress (46%) […] 2 erythema nodosum patients report mild stress (15%) […] 2 erythema nodosum patients report no stress (15%). […] Common symptom Anxious mood […] 5 erythema nodosum patients report severe anxious mood (11%) […] 13 erythema nodosum patients report moderate anxious mood (28%) […] 17 erythema nodosum patients report mild anxious mood (37%) […] 10 erythema nodosum patients report no anxious mood (22%). […] Common symptom Depressed mood […] 4 erythema nodosum patients report severe depressed mood (9%) […] 15 erythema nodosum patients report moderate depressed mood (34%) […] 11 erythema nodosum patients report mild depressed mood (25%) […] 14 erythema nodosum patients report no depressed mood (31%).

• #61 Erythema Nodosum: A Practical Approach and Diagnostic Algorithm

  https://pmc.ncbi.nlm.nih.gov/articles/PMC7938036/

  The diagnosis is usually made in a characteristic clinical scenario and is easily distinguished from other nodular lesions. However, it should be confirmed by a deep incisional or excisional biopsy with a generous portion of subcutaneous fat. […] The prognosis of EN is usually excellent with spontaneous resolution of the lesions in most patients. However, when an underlying condition is identified, it should be treated, and if a drug has been identified as a trigger, it should be withdrawn when feasible.

• #62 Erythema Nodosum | Doctor

  https://patient.info/doctor/erythema-nodosum-pro

  When the aetiology is an infection the lesions usually heal in six to eight weeks but 30% of idiopathic cases last six months. Arthralgia occurs in more than half of patients and begins either during the eruptive phase or two to four weeks before. Joints are red, swollen and tender, sometimes with effusions. Morning stiffness may occur. The ankles, knees and wrists are most often involved. Synovitis resolves in a few weeks but joint pain and stiffness may last up to six months. There are no destructive changes in the joint and synovial fluid is acellular and the rheumatoid factor is negative. […] Erythema nodosum usually resolves within six weeks but it may be more protracted, especially if the underlying cause of erythema nodosum remains or when it is idiopathic. Serious complications are unusual unless part of the underlying disease. Chronic or recurrent disease is rare. Lesions heal without atrophy or scarring.

• #63 Erythema Nodosum Clinical Presentation: History, Physical Examination

  https://emedicine.medscape.com/article/1081633-clinical

  Characteristically, lesions appear on the anterior leg; however, they may appear on any surface. In the second week, they change color from bright red to bluish or livid. As absorption progresses, the color gradually fades to a yellowish hue, resembling a bruise. This disappears in 1-2 weeks as the overlying skin desquamates. […] Arthralgia occurs in more than 50% of patients and, as noted, may begin either during the eruptive phase or 2-4 weeks before the eruption. Erythema, swelling, and tenderness occur over the joint, sometimes with effusions. Joint tenderness and morning stiffness may occur. Any joint may be involved, but the ankles, knees, and wrist are affected most commonly. Although synovitis resolves within a few weeks, joint pain and stiffness may last as long as 6 months. No destructive joint changes occur. Synovial fluid is acellular, and rheumatoid factor is negative.

• #64 Erythema Nodosum: Symptoms, Causes, Treatments and More

  https://www.healthline.com/health/erythema-nodosum

  Erythema nodosum can be uncomfortable, but it’s usually not serious. […] The bumps will often fade within two to four weeks, but they can take up to two months to heal completely. You’ll likely have some bruising as the bumps fade, but they usually don’t leave scars. […] Pain in your legs can continue for up to two years after erythema nodosum heals. It’s also possible the condition can come back in the future.

• #65 Erythema Nodosum | Doctor

  https://patient.info/doctor/erythema-nodosum-pro

  When the aetiology is an infection the lesions usually heal in six to eight weeks but 30% of idiopathic cases last six months. Arthralgia occurs in more than half of patients and begins either during the eruptive phase or two to four weeks before. Joints are red, swollen and tender, sometimes with effusions. Morning stiffness may occur. The ankles, knees and wrists are most often involved. Synovitis resolves in a few weeks but joint pain and stiffness may last up to six months. There are no destructive changes in the joint and synovial fluid is acellular and the rheumatoid factor is negative. […] Erythema nodosum usually resolves within six weeks but it may be more protracted, especially if the underlying cause of erythema nodosum remains or when it is idiopathic. Serious complications are unusual unless part of the underlying disease. Chronic or recurrent disease is rare. Lesions heal without atrophy or scarring.

• #66 Erythema Nodosum: A Sign of Systemic Disease | AAFP

  https://www.aafp.org/pubs/afp/issues/2007/0301/p695.html

  Erythema nodosum, a painful disorder of the subcutaneous fat, is the most common type of panniculitis. The hallmark of erythema nodosum is tender, erythematous, subcutaneous nodules that typically are located symmetrically on the anterior surface of the lower extremities. Erythema nodosum tends to be self-limited. Painful, symmetric, red nodules Anterior legs most common location Involutes in weeks with bruise-like appearance Does not ulcerate; tends to heal completely. Initially, erythema nodosum nodules can be firm, but they usually become more fluctuant during the clinical evolution. Individual nodules may last for two weeks; new outcroppings may continue to arise for up to six weeks. These nodules often take approximately one to two months to heal completely and may assume a bruise-like appearance as they fade. A prodrome commonly occurs as early as one to three weeks before the onset of erythema nodosum, regardless of the etiology. Specific symptoms may include weight loss, malaise, low-grade fever, cough, and arthralgia with or without arthritis. Arthralgias have been known to persist for up to two years after the resolution of erythema nodosum. Erythema nodosum migrans, subacute nodular migratory panniculitis, and chronic erythema nodosum, disorders classically considered distinct from erythema nodosum, now are considered to be variants in the same disease spectrum.

• #67 Erythema Nodosum – StatPearls – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK470369/

  Erythema nodosum (EN) is a common acute nodular septal panniculitis, characterized by the sudden onset of erythematous, firm, solid, deep nodules or plaques that are painful on palpation and mainly localized on extensor surfaces of the legs. […] Erythema nodosum is characterized in a rather stereotyped way, whatever its cause, by the following evolutionary aspects: […] The general syndrome occurs with fever, and arthralgia of the prodromal phase persists or increases. […] Nodules appear on the extensor surfaces of the legs and knees, and sometimes thighs and forearms. […] Each nodule evolves in ten days, taking blue and yellowish contusiform aspects towards complete disappearance without sequelae. […] EN never involves necrosis, ulceration, or scarring. […] The prognosis for patients with EN is good but there is a small risk of recurrence. The skin lesions often take months to resolve but there is usually no scarring or pigmentation change.

• #68 Erythema Nodosum | Doctor

  https://patient.info/doctor/erythema-nodosum-pro

  Erythema nodosum symptoms […] The eruptive phase of erythema nodosum begins with fever, aching and arthralgia, accompanied by a painful rash. Lesions begin as red, tender nodules. The borders are poorly defined and they are 2-6 cms in diameter. In the first week of having erythema nodosum the lesions become tense, hard and painful. In the second week, they may become fluctuant, rather like an abscess but they do not suppurate or ulcerate. Individual lesions last around two weeks but occasionally, new lesions continue to appear for three to six weeks. Aching legs and swollen ankles may persist for many weeks. In the first week they are bright red but in the second week there is a blue or purple hue, even turning yellow like a resolving bruise before disappearing in a couple of weeks. They can occur anywhere but are usually on the anterior aspect of the lower leg.

• #69 Erythema Nodosum Clinical Presentation: History, Physical Examination

  https://emedicine.medscape.com/article/1081633-clinical

  The eruptive phase of erythema nodosum (EN) begins with flulike symptoms of fever and generalized aching. Arthralgia may occur, appearing either before the eruption or during the eruptive phase. With infection-induced EN, most lesions heal within 7 weeks, though active disease may last as long as 18 weeks. In contrast, 30% of idiopathic EN cases may last longer than 6 months. Febrile illness with dermatologic findings includes abrupt onset of illness with initial fever, followed by a painful rash within 1-2 days. […] Lesions begin as red tender nodules. Their borders are poorly defined, and the range in size from 2 to 6 cm. During the first week, lesions become tense, hard, and painful; during the second week, they may become fluctuant, as in an abscess, but do not suppurate or ulcerate. Individual lesions last approximately 2 weeks, but occasionally, new lesions continue to appear for 3-6 weeks. Aching legs and swelling ankles may persist for weeks.

• #70 Erythema nodosum

  https://www.nhs.uk/conditions/erythema-nodosum/

  Erythema nodosum is a condition that causes painful patches of skin that look red or darker than the surrounding skin. It usually goes away by itself, but it can sometimes be a sign of something serious like an inflammatory bowel condition, such as Crohn’s disease. […] If you have erythema nodosum, you may have flu-like symptoms before or at the same time as you get the patches on your skin. […] The skin usually heals on its own within 3 to 8 weeks without leaving a scar. But other symptoms, such as joint pain and swelling, can last for several weeks. […] If your symptoms have lasted a long time or they keep returning, other treatments, such as steroid tablets, may be recommended.

• #71 Erythema nodosum

  https://www.nhs.uk/conditions/erythema-nodosum/

  Erythema nodosum is a condition that causes painful patches of skin that look red or darker than the surrounding skin. It usually goes away by itself, but it can sometimes be a sign of something serious like an inflammatory bowel condition, such as Crohn’s disease. […] If you have erythema nodosum, you may have flu-like symptoms before or at the same time as you get the patches on your skin. […] The skin usually heals on its own within 3 to 8 weeks without leaving a scar. But other symptoms, such as joint pain and swelling, can last for several weeks. […] If your symptoms have lasted a long time or they keep returning, other treatments, such as steroid tablets, may be recommended.

• #72 Erythema nodosum: Symptoms, Causes, and Management — DermNet

  https://dermnetnz.org/topics/erythema-nodosum

  Erythema nodosum presents with tender bilateral erythematous subcutaneous nodules 320 cm in diameter erupting over one to several weeks. They are accompanied by fever and joint pain. In 50% the ankle is swollen and painful for up to several weeks. The knees and other joints can also be affected. […] Erythema nodosum follows a relatively benign and favourable course. It is important to recognise the underlying cause, if any, and initiate symptomatic treatment. Most cases resolve within days to weeks. Relapses may occur in approximately one-third of cases erythema nodosum may become a chronic or persistent disorder lasting for 6 months and occasionally for years.

• #73 Erythema Nodosum: Symptoms, Causes & Treatment

  https://my.clevelandclinic.org/health/diseases/24565-erythema-nodosum

  Erythema nodosum can resolve on its own after a few weeks to months and doesn’t always need treatment. […] After treatment begins, you could see your symptoms of pain and swelling reduce. The bumps (nodules) and visible signs of the condition will still be on your skin for several weeks to months. During this time, your skin might change color, from red and purple to brown, before returning to your natural skin color. This is normal. […] Erythema nodosum can return throughout your life after it goes away. If you manage or treat the underlying condition that caused your symptoms or you stop taking medicine that caused your symptoms, you reduce your risk of having an erythema nodosum flare.

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