Materiały źródłowe

• #1 Prediabetes Education & Treatments: Steps to Prevent Type 2 Diabetes

  https://diabetes.org/about-diabetes/prediabetes

  For some people with prediabetes, early treatment as well as moderate lifestyle changes can actually return blood glucose (blood sugar) levels to a normal range, effectively preventing or delaying type 2 diabetes. […] If you discover that you do have prediabetes, remember that it doesnt mean youll develop type 2, particularly if you follow a treatment plan and make changes to your lifestyle through food choices and physical activity. […] A CDC-recognized lifestyle change program could cut your risk of developing type 2 diabetes in half. […] With prediabetes, there are simple steps you can take to change things, such as adapting your food choices and increasing your daily physical activity to lose weight, if needed. […] Take steps to prevent or delay the onset of type 2 diabetes.

• #2 Prediabetes diagnosis and treatment: A review

  https://pmc.ncbi.nlm.nih.gov/articles/PMC4360422/

  Prediabetes is a condition defined as having blood glucose levels above normal but below the defined threshold of diabetes. It is considered to be an at risk state, with high chances of developing diabetes. […] Several studies have shown efficacy of lifestyle interventions with regards to diabetes prevention with a relative risk reduction of 40%-70% in adults with prediabetes. […] While there is increasing evidence to prove the efficacy of pharmacotherapy in prevention of diabetes in adults with prediabetes, pharmaceutical treatment options other than metformin are associated with adverse effects that limit their use for prediabetes. […] Secondary intervention with pharmacotherapy with metformin is advocated for high-risk individuals but criteria for such consideration benefit of early intervention, long term cost effectiveness of such interventions and the end point of therapy remain unclear.

• #3 Prediabetes: Diagnosis & Treatment | NewYork-Presbyterian

  https://www.nyp.org/primary-care/prediabetes/treatment

  Prediabetes is reversible. Implementing dietary and lifestyle changes can help normalize blood sugar levels and lower your risk of developing type 2 diabetes. Your doctor can also recommend medications that can decrease your risk for progression to diabetes. In general, however, physicians do not prescribe medications for prediabetes alone. […] Prediabetes treatment includes adopting a healthier routine to reduce your blood sugar levels and risk factors for developing type 2 diabetes. This includes maintaining a healthy weight, quitting smoking, avoiding heavy alcohol consumption, and exercising regularly. […] If dietary and lifestyle changes aren’t helping to reduce your blood sugar levels, and you are at risk for developing type 2 diabetes, your doctor may prescribe medication to delay the progression to diabetes. This could include drugs such as metformin or weight loss medications. […] NewYork-Presbyterian is home to compassionate primary care physicians who are familiar with the care of patients with prediabetes. We’re here to support you in reversing prediabetes and preventing type 2 diabetes.

• #4 Prediabetes treatment – Diabetes Canada

  https://www.diabetes.ca/about-diabetes/prediabetes/treatment

  Prediabetes is a precursor for type 2 diabetes. […] The good news is that more than half of people with prediabetes can delay or prevent the onset of type 2 diabetes. Taking steps now to improve your lifestyle can make a huge difference and lead to a healthier future. […] If you’ve been diagnosed with prediabetes, reduce your risk of developing type 2 diabetes by: following a health-promoting dietary pattern (see Canada’s Food Guide), exercising regularly (start slowly and increase to 150 minutes per week), discussing weight management with your healthcare provider. […] Healthy choices are vital to managing prediabetes and preventing type 2 diabetes. […] Diabetes Canada is here to help provide information and support so that you can live a healthy life. You may also talk to your healthcare team about support and services available in your community, such as: prediabetes education or diabetes prevention program, registered dietitian, exercise specialist, goal-setting. […] A 12-month, digital coaching program that empowers you to lead a healthier life and reduce your risk of developing Type 2 diabetes.

• #5 Diagnosis and Management of Prediabetes: A Review – PubMed

  https://pubmed.ncbi.nlm.nih.gov/37039787/

  Prediabetes is associated with increased risk of diabetes, cardiovascular events, and mortality. […] First-line therapy for prediabetes is lifestyle modification that includes weight loss and exercise or metformin. […] Lifestyle modification is associated with a larger benefit than metformin. […] Intensive lifestyle modification, consisting of calorie restriction, increased physical activity (150 min/wk), self-monitoring, and motivational support, decreased the incidence of diabetes by 6.2 cases per 100 person-years during a 3-year period. […] Metformin decreased the risk of diabetes among individuals with prediabetes by 3.2 cases per 100 person-years during 3 years. […] Metformin is most effective for women with prior gestational diabetes and for individuals younger than 60 years with body mass index of 35 or greater, fasting plasma glucose level of 110 mg/dL or higher, or HbA1c level of 6.0% or higher.

• #6 Prevention or Delay of Type 2 Diabetes Mellitus: Recommendations From the American Diabetes Association | AAFP

  https://www.aafp.org/pubs/afp/issues/2022/0400/p438.html

  Prediabetes is not a diagnosis but rather an opportunity to prevent or delay a future diagnosis of type 2 diabetes. […] Intensive lifestyle programs are the most effective intervention for preventing or delaying a diagnosis of diabetes in patients with prediabetes. […] In patients with prediabetes, metformin therapy will slow the progression to type 2 diabetes, although less effectively than lifestyle programs over time. […] In patients who have had gestational diabetes, the benefits of metformin therapy are similar to those of lifestyle programs. […] Strong evidence supports lifestyle interventions to delay or prevent diabetes. Programs that include diet, weight loss, and exercise reduce type 2 diabetes diagnoses by up to 58% over three years. […] Programs should be modeled after the National Diabetes Prevention Program, which targets sustained weight loss of at least 7% of body weight and at least 150 minutes of moderate-intensity exercise weekly.

• #7 Prediabetes – Diagnosis and treatment – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/prediabetes/diagnosis-treatment/drc-20355284

  Healthy lifestyle choices can help you bring your blood sugar level back to normal, or at least keep it from rising toward the levels seen in type 2 diabetes. […] To prevent prediabetes from progressing to type 2 diabetes, try to: […] Eat healthy foods. A diet high in fruits, vegetables, nuts, whole grains and olive oil is associated with a lower risk of prediabetes. Choose foods low in fat and calories and high in fiber. Eat a variety of foods to help you achieve your goals without compromising taste or nutrition. […] Be more active. Physical activity helps you control your weight, uses up sugar for energy and helps the body use insulin more effectively. Aim for at least 150 minutes of moderate or 75 minutes of vigorous aerobic activity a week, or a combination of moderate and vigorous exercise.

• #8 Prediabetes: What Is It, Causes, Symptoms & Treatment

  https://my.clevelandclinic.org/health/diseases/21498-prediabetes

  Prediabetes is a warning of Type 2 diabetes. […] There are lifestyle changes you can make to manage or reverse prediabetes, like getting more physical activity and adjusting eating patterns and habits. […] The good news is that its possible to reverse prediabetes with healthy lifestyle changes. […] The best way to treat and potentially reverse prediabetes is through healthy lifestyle changes. Regularly eating nutritious foods and getting regular exercise can help return your blood sugar to healthy levels and prevent or delay Type 2 diabetes. […] Even small changes can significantly lower your risk for developing Type 2 diabetes, like: […] Your healthcare provider may recommend trying to lose excess weight to combat insulin resistance and prediabetes. […] Getting regular amounts of moderate-intensity physical activity helps increase glucose usage and improve muscle insulin sensitivity.

• #9 Prevention or Delay of Type 2 Diabetes Mellitus: Recommendations From the American Diabetes Association | AAFP

  https://www.aafp.org/pubs/afp/issues/2022/0400/p438.html

  Although weight loss is considered the most important factor for lowering the risk of type 2 diabetes, achieving the physical activity goal of at least 150 minutes per week can reduce diabetes incidence by 44% without weight loss. […] Medications can delay or prevent type 2 diabetes but are less effective than lifestyle programs. Metformin has the strongest evidence, whereas liraglutide, insulin, thiazolidinediones, alpha-glucosidase inhibitors, orlistat (Xenical), and phentermine/topiramate (Qsymia) all have some evidence of benefit. […] In patients with previous gestational diabetes, metformin reduces diabetes incidence by 50%, equivalent to lifestyle changes. […] Although evidence is limited, annual laboratory monitoring is recommended for patients with prediabetes to track treatment effectiveness and the development of type 2 diabetes.

• #10 Prediabetes Diagnosis & Treatment | TPMG Nutrition Services

  https://www.mytpmg.com/blog/prediabetes/

  If you have prediabetes, you can reverse your condition and keep your blood sugar within normal range by making some lifestyle changes which includes physical activity. Aiming for at least 150 minutes of physical activity per week is recommended. This can mean intense activity like running or something simpler like a bike ride or walking through the mall. If you have trouble making time for physical activity in your schedule, consider breaking up those 150 minutes into more manageable portions of time. Try exercising for 30 minutes, five times a week instead of once or twice for longer. […] Managing prediabetes also includes healthy, well balanced meals with proper portions. Reducing unnecessary snacking, eliminating sweet drinks and not skipping meals will also help. Extreme dieting is not needed nor recommended. TPMG registered dietitians can meet with you and help with meal plans that align with your preferences and lifestyle. In addition, TPMG offers prediabetes classes that are fully recognized by the Centers for Disease Control and Prevention (CDC). The weight reduction and diabetes prevention program is a year-long program that focuses on improving food choices, increasing activity, and controlling portions.

• #11 Prediabetes – Diagnosis and treatment – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/prediabetes/diagnosis-treatment/drc-20355284

  Healthy lifestyle choices can help you bring your blood sugar level back to normal, or at least keep it from rising toward the levels seen in type 2 diabetes. […] To prevent prediabetes from progressing to type 2 diabetes, try to: […] Eat healthy foods. A diet high in fruits, vegetables, nuts, whole grains and olive oil is associated with a lower risk of prediabetes. Choose foods low in fat and calories and high in fiber. Eat a variety of foods to help you achieve your goals without compromising taste or nutrition. […] Be more active. Physical activity helps you control your weight, uses up sugar for energy and helps the body use insulin more effectively. Aim for at least 150 minutes of moderate or 75 minutes of vigorous aerobic activity a week, or a combination of moderate and vigorous exercise.

• #12 Prediabetes: What Is It, Causes, Symptoms & Treatment

  https://my.clevelandclinic.org/health/diseases/21498-prediabetes

  Cutting out added sugars, swapping simple carbohydrates for complex carbohydrates and eating more veggies can help your blood sugar return to healthy levels. […] Lowering your risk factors for prediabetes can often get your blood sugar levels back to healthy levels. […] In some cases, your healthcare provider may recommend taking certain oral diabetes medications. […] The most common medications providers prescribe for prediabetes are metformin and acarbose. […] The strategies for preventing prediabetes are the same as for reversing it and preventing Type 2 diabetes. […] If you receive a prediabetes diagnosis, youll need to make lifestyle changes to manage or reverse it. […] Without taking action, many people with prediabetes eventually develop Type 2 diabetes.

• #13 Prediabetes Treatment | University of Utah Health

  https://healthcare.utah.edu/primary-care/prediabetes

  The most powerful action you can take to reverse prediabetes is to make lifelong changes to your diet and exercise. Medication may help, too. […] A healthy diet is critical in reversing prediabetes. If you aren’t sure where to start, consider making an appointment with a registered dietitian at U of U Health. You’ll learn how to follow a diet that’s rich in fruit, vegetables, whole grains, nuts, healthy oils, and lean meat. The dietitian can help you set realistic goals and meet them. […] Get at least 150 minutes of moderate physical activity a week. Be sure to find an activity you enjoy. Recommended activities include walking, jogging, running, biking, swimming, and exercise classes, such as yoga or spinning. Regular exercise has the added benefit of reducing stress, which is associated with better blood sugar control. […] Your doctor may prescribe medication to help treat prediabetes and conditions related to it. These can include: metformin for blood sugar control, cholesterol-lowering medications, and high blood pressure medications.

• #14 Prediabetes: MedlinePlus Medical EncyclopediaLock

  https://medlineplus.gov/ency/patientinstructions/000778.htm

  Prediabetes occurs when the level of sugar (glucose) in your blood is too high, but not high enough to be called diabetes. […] Losing extra weight and getting regular exercise will reduce the chance of your prediabetes becoming type 2 diabetes. […] To help you prevent diabetes, your provider will likely suggest certain lifestyle changes: Eat healthy foods. This includes whole grains, lean proteins, low-fat dairy, and plenty of vegetables. Watch portion sizes and avoid sweets, fried foods, and excessive amount of fruits. […] Lose weight. Just a small weight loss can make a big difference in your health. […] Get more exercise. Aim to get at least 30 to 60 minutes of moderate exercise at least 5 days a week. […] Take medicines as directed. Your provider may prescribe metformin or another medicine to reduce the chance that your prediabetes will progress to diabetes. […] Having prediabetes is a wake-up call to take action to improve your health.

• #15 Prediabetes – Diagnosis and treatment – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/prediabetes/diagnosis-treatment/drc-20355284

  Lose excess weight. If you’re overweight, losing just 5% to 7% of your body weight about 14 pounds (6.4 kilograms) if you weigh 200 pounds (91 kilograms) can significantly reduce the risk of type 2 diabetes. To keep your weight in a healthy range, focus on permanent changes to your eating and exercise habits. […] Stop smoking. Stopping smoking can improve the way insulin works, improving your blood sugar level. […] Take medications as needed. If you’re at high risk of diabetes, your health care provider might recommend metformin (Glumetza). Medications to control cholesterol and high blood pressure might also be prescribed. […] Children with prediabetes should follow the lifestyle changes recommended for adults with type 2 diabetes, including: […] Medication generally isn’t recommended for children with prediabetes unless lifestyle changes aren’t improving blood sugar levels. If medication is needed, metformin is usually the recommended drug.

• #16 Prediabetes Is on the Rise—But It Can Be Reversed > News > Yale Medicine

  https://www.yalemedicine.org/news/prediabetes

  Losing even a modest amount of weight may change the prognosis. […] You can still prevent or delay type 2 diabetes by losing weighteven a modest amountwith the help of dietary changes, stress reduction, and physical activity. Taking medication can also help. […] Weight loss is a key strategy to reverse prediabetes, but its important to know that not everyone needs to lose a massive amount of weight, doctors say. Often only minor changes in dietary intake and minimal weight loss, together with more physical activity, will help chase diabetes away, says Sonia Caprio, MD, a Yale Medicine pediatric endocrinologist. […] The CDCs national Diabetes Prevention Program (DPP), which includes an ongoing Outcomes Study, has shown that people with prediabetes who lost a modest amount of weight5 to 7% (10 to 14 pounds for a person weighing 200 pounds, for example)with the help of a structured lifestyle-change program cut their risk of developing type 2 diabetes by 58%.

• #17 Prediabetes – Your Chance to Prevent Type 2 Diabetes | Diabetes | CDC

  https://www.cdc.gov/diabetes/prevention-type-2/prediabetes-prevent-type-2.html

  If you have prediabetes, the CDC-led National Diabetes Prevention Program lifestyle change program can help. When you join, you’ll learn to make lifestyle changes that lower your risk and improve your health. […] If you have prediabetes, you can lower your risk for developing type 2 diabetes by: Losing a small amount of weight if you have overweight. Getting regular physical activity. […] The CDC-led National Diabetes Prevention Program can help you make those changes and make them stick. Through the program, you can lower your risk for type 2 diabetes by 58% (71% if you’re over age 60).

• #18 Tips to Reverse Prediabetes Naturally: 8 Tips to Try Now

  https://www.healthline.com/health/diabetes/how-to-reverse-prediabetes-naturally

  Though having prediabetes doesnt mean you are about to develop diabetes, its a good idea to take action to reverse the condition. Changing your diet and lifestyle habits can make a big difference. […] A prediabetes diagnosis, however, doesnt mean that youll develop type 2 diabetes. Some people have successfully reversed prediabetes by modifying their diet and lifestyle. […] Eating a clean diet, which consists of healthier choices, can help restore normal blood sugar levels. This can reverse prediabetes and help prevent type 2 diabetes. […] Exercise is not only great for energy and mental health, it can also lower your blood sugar by increasing insulin sensitivity. This allows the cells in your body to use insulin more efficiently. […] In fact, losing as little as 5 to 10 percent of body fat can improve your blood sugar level and help reverse prediabetes.

• #19 Prediabetes Is on the Rise—But It Can Be Reversed > News > Yale Medicine

  https://www.yalemedicine.org/news/prediabetes

  Losing even a modest amount of weight may change the prognosis. […] You can still prevent or delay type 2 diabetes by losing weighteven a modest amountwith the help of dietary changes, stress reduction, and physical activity. Taking medication can also help. […] Weight loss is a key strategy to reverse prediabetes, but its important to know that not everyone needs to lose a massive amount of weight, doctors say. Often only minor changes in dietary intake and minimal weight loss, together with more physical activity, will help chase diabetes away, says Sonia Caprio, MD, a Yale Medicine pediatric endocrinologist. […] The CDCs national Diabetes Prevention Program (DPP), which includes an ongoing Outcomes Study, has shown that people with prediabetes who lost a modest amount of weight5 to 7% (10 to 14 pounds for a person weighing 200 pounds, for example)with the help of a structured lifestyle-change program cut their risk of developing type 2 diabetes by 58%.

• #20 Prediabetes – Diagnosis and treatment – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/prediabetes/diagnosis-treatment/drc-20355284

  Lose excess weight. If you’re overweight, losing just 5% to 7% of your body weight about 14 pounds (6.4 kilograms) if you weigh 200 pounds (91 kilograms) can significantly reduce the risk of type 2 diabetes. To keep your weight in a healthy range, focus on permanent changes to your eating and exercise habits. […] Stop smoking. Stopping smoking can improve the way insulin works, improving your blood sugar level. […] Take medications as needed. If you’re at high risk of diabetes, your health care provider might recommend metformin (Glumetza). Medications to control cholesterol and high blood pressure might also be prescribed. […] Children with prediabetes should follow the lifestyle changes recommended for adults with type 2 diabetes, including: […] Medication generally isn’t recommended for children with prediabetes unless lifestyle changes aren’t improving blood sugar levels. If medication is needed, metformin is usually the recommended drug.

• #21 Tips to Reverse Prediabetes Naturally: 8 Tips to Try Now

  https://www.healthline.com/health/diabetes/how-to-reverse-prediabetes-naturally

  Smoking is also a risk factor for insulin resistance, prediabetes, and type 2 diabetes. […] Even if youre committed to healthy eating, its important to choose your carbohydrates carefully. […] Drinking water is another excellent way to help reverse prediabetes and prevent type 2 diabetes. […] Even though some people reverse prediabetes with lifestyle changes, this isnt enough for everyone. […] Medications to help lower blood sugar and reverse prediabetes include metformin (Glucophage, Fortamet) or a similar drug. […] A prediabetes diagnosis doesnt mean that youll develop type 2 diabetes. But youll need to take quick action to reverse the condition.

• #22 Prediabetes Treatment: Learn to Lower Blood Sugar Levels Naturally

  https://www.harmonyhealthcareli.org/prediabetes-treatment/

  Although a diagnosis of prediabetes can be scary and might even seem life-changing, you still have the power to get your health on the right track. In prediabetes treatment, action is the best medicine to prevent or delay the development of type 2 diabetes. […] By following a healthy diet consistently, you can reduce your diabetes risk and improve your overall health. […] Shedding some pounds is highly recommended for prediabetes treatment. Research has found that people with this condition who lose around 10 percent of their body weight within six months of being diagnosed significantly reduce their risk of developing type 2 diabetes. […] Smoking and drinking are two of the worst habits for prediabetics. Smoking promotes insulin resistance, which increases the risk of heart disease and stroke. […] Drinking is also problematic for those with prediabetes. Alcohol interferes with insulin and can lead to imbalanced blood sugar levels. […] If you have been diagnosed as being prediabetic, taking action is the best way to protect your short- and long-term health.

• #23 Prediabetes Treatment: Learn to Lower Blood Sugar Levels Naturally

  https://www.harmonyhealthcareli.org/prediabetes-treatment/

  Although a diagnosis of prediabetes can be scary and might even seem life-changing, you still have the power to get your health on the right track. In prediabetes treatment, action is the best medicine to prevent or delay the development of type 2 diabetes. […] By following a healthy diet consistently, you can reduce your diabetes risk and improve your overall health. […] Shedding some pounds is highly recommended for prediabetes treatment. Research has found that people with this condition who lose around 10 percent of their body weight within six months of being diagnosed significantly reduce their risk of developing type 2 diabetes. […] Smoking and drinking are two of the worst habits for prediabetics. Smoking promotes insulin resistance, which increases the risk of heart disease and stroke. […] Drinking is also problematic for those with prediabetes. Alcohol interferes with insulin and can lead to imbalanced blood sugar levels. […] If you have been diagnosed as being prediabetic, taking action is the best way to protect your short- and long-term health.

• #24 You’re Prediabetic: Now What? | University Hospitals

  https://www.uhhospitals.org/blog/articles/2023/01/youre-prediabetic-now-what

  When you have prediabetes, eating certain foods and avoiding others can help balance your blood sugar levels and even reverse the condition. […] Poor sleep can worsen insulin resistance and make controlling your blood sugar more difficult. Sleep deprivation can also increase the chance that your prediabetes will progress into type 2 diabetes.

• #25 Prediabetes Treatment Marin County | Diabetes Prevention

  https://www.mymarinhealth.org/programs-services/endocrine-diabetes-care/diabetes-care/prediabetes-prevention/

  Taught by our team of experts, our Diabetes Prevention Program can help you learn what steps you can take to prevent prediabetes from developing into type 2 diabetes. […] According to the American Diabetes Association, research shows that you can lower your risk of developing type 2 diabetes by 58 percent if you take these preventive measures: […] Lose 7 percent of your body weight. Even a 10- to 15-pound weight loss can make a big difference. In addition to helping reduce your risk of developing type 2 diabetes, losing weight lowers your risk of heart disease and lowers blood pressure, cholesterol, and blood glucose. […] Exercise moderately 30 minutes a day, five days a week. […] Practice stress management techniques. Try yoga, meditation, massage, and acupuncture or similar activities.

• #26 Tips to Reverse Prediabetes Naturally: 8 Tips to Try Now

  https://www.healthline.com/health/diabetes/how-to-reverse-prediabetes-naturally

  Smoking is also a risk factor for insulin resistance, prediabetes, and type 2 diabetes. […] Even if youre committed to healthy eating, its important to choose your carbohydrates carefully. […] Drinking water is another excellent way to help reverse prediabetes and prevent type 2 diabetes. […] Even though some people reverse prediabetes with lifestyle changes, this isnt enough for everyone. […] Medications to help lower blood sugar and reverse prediabetes include metformin (Glucophage, Fortamet) or a similar drug. […] A prediabetes diagnosis doesnt mean that youll develop type 2 diabetes. But youll need to take quick action to reverse the condition.

• #27 Prevention or Delay of Type 2 Diabetes Mellitus: Recommendations From the American Diabetes Association | AAFP

  https://www.aafp.org/pubs/afp/issues/2022/0400/p438.html

  Although weight loss is considered the most important factor for lowering the risk of type 2 diabetes, achieving the physical activity goal of at least 150 minutes per week can reduce diabetes incidence by 44% without weight loss. […] Medications can delay or prevent type 2 diabetes but are less effective than lifestyle programs. Metformin has the strongest evidence, whereas liraglutide, insulin, thiazolidinediones, alpha-glucosidase inhibitors, orlistat (Xenical), and phentermine/topiramate (Qsymia) all have some evidence of benefit. […] In patients with previous gestational diabetes, metformin reduces diabetes incidence by 50%, equivalent to lifestyle changes. […] Although evidence is limited, annual laboratory monitoring is recommended for patients with prediabetes to track treatment effectiveness and the development of type 2 diabetes.

• #28 Prediabetes Treatment in Delhi, India | Symptoms, Causes & Diagnosis

  https://www.maxhealthcare.in/our-specialities/diabetes-endocrinology/conditions-treatments/prediabetes

  Prediabetes Treatment […] A healthy lifestyle and eating choices can help to control the blood sugar level and may bring it back to normal. Also, help to stop from rising to type 2 diabetes. There is no clear prediabetes treatment, oral medications, insulin shots and lifestyle changes act. […] Consume Healthy Food: A balanced food intake of fruits, vegetables, lean protein, healthy fats like nuts seeds vegetable oils, whole pulses and whole grains reduces the risk of prediabetes. Choose food that is low in simple sugars, fats and high in fibre. Healthy food can prevent blood glucose levels from rising. […] Exercise and Activity: Physical activity and exercise use glucose for energy also help the body to use insulin more effectively. […] Quit Smoking: Quitting smoking can help the insulin to work more efficiently. […] Medications: The doctor may recommend medication such as metformin, to reduce the risk of diabetes. Medications to control high blood pressure and cholesterol can also be given.

• #29 Medications for Prediabetes

  https://www.prediabetes.co.uk/guides/prediabetes-medications

  In most cases, people diagnosed with prediabetes do not need to take medication to treat the condition. […] Following your prediabetes diagnosis, certain factors might mean you are prescribed medication as part of your treatment, including: […] Alongside taking any prescribed medication, you should still participate in a healthy lifestyle to have the strongest chance of taking control of your blood sugar levels. […] Metformin is currently the only drug recommended by the ADA as an effective treatment for prediabetes. […] However, most people can treat their prediabetes by adopting a lifestyle involving regularly activity and a healthy diet. In fact, evidence shows it can be effectively put into remission. […] Following a diet low in carbohydrates has been clinically proven to help stabilise blood sugars and put prediabetes and type 2 diabetes into remission. […] The program has helped members lose an average of 7% of their body weight, reduce the amount of medication they need to take, and more importantly, lower their blood glucose to the recommended levels.

• #30 Diagnosis and Management of Prediabetes: A Review – PubMed

  https://pubmed.ncbi.nlm.nih.gov/37039787/

  Prediabetes is associated with increased risk of diabetes, cardiovascular events, and mortality. […] First-line therapy for prediabetes is lifestyle modification that includes weight loss and exercise or metformin. […] Lifestyle modification is associated with a larger benefit than metformin. […] Intensive lifestyle modification, consisting of calorie restriction, increased physical activity (150 min/wk), self-monitoring, and motivational support, decreased the incidence of diabetes by 6.2 cases per 100 person-years during a 3-year period. […] Metformin decreased the risk of diabetes among individuals with prediabetes by 3.2 cases per 100 person-years during 3 years. […] Metformin is most effective for women with prior gestational diabetes and for individuals younger than 60 years with body mass index of 35 or greater, fasting plasma glucose level of 110 mg/dL or higher, or HbA1c level of 6.0% or higher.

• #31 Diagnosis and Management of Prediabetes: A Review – PubMed

  https://pubmed.ncbi.nlm.nih.gov/37039787/

  Prediabetes is associated with increased risk of diabetes, cardiovascular events, and mortality. […] First-line therapy for prediabetes is lifestyle modification that includes weight loss and exercise or metformin. […] Lifestyle modification is associated with a larger benefit than metformin. […] Intensive lifestyle modification, consisting of calorie restriction, increased physical activity (150 min/wk), self-monitoring, and motivational support, decreased the incidence of diabetes by 6.2 cases per 100 person-years during a 3-year period. […] Metformin decreased the risk of diabetes among individuals with prediabetes by 3.2 cases per 100 person-years during 3 years. […] Metformin is most effective for women with prior gestational diabetes and for individuals younger than 60 years with body mass index of 35 or greater, fasting plasma glucose level of 110 mg/dL or higher, or HbA1c level of 6.0% or higher.

• #32 Anticipating Tomorrow: Advances in Prediabetes Treatment

  https://www.delveinsight.com/blog/prediabetes-treatment

  Metformin functions as an antihyperglycemic agent, enhancing glucose tolerance in individuals with prediabetes or type 2 diabetes by reducing both basal and postprandial plasma glucose levels. […] Commonly utilized thiazolidinediones for prediabetes treatment encompass troglitazone, pioglitazone, rosiglitazone, and others. […] Another category of medications prescribed for prediabetes treatment includes orally administered GLP-1 analogs, which elicit a two- to three-fold increase in plasma insulin response compared to the same level of hyperglycemia induced by intravenous glucose. […] The next category of medication for prediabetes treatment involves DPP-IV inhibitors, exemplified by vildagliptin. […] Lastly, alpha-glucosidase inhibitors, sometimes termed starch blockers, function as antidiabetic medications that reduce postmeal blood glucose levels.

• #33 Prediabetes | Kaiser Permanente

  https://healthy.kaiserpermanente.org/health-wellness/health-encyclopedia/he.prediabetes.uz1410

  Prediabetes can be treated by making lifestyle changes, taking medicine, or doing both. […] Treatment focuses on: Staying at a weight that’s healthy for you. A healthy weight helps your body use insulin the way it should. If you’re at a higher weight, losing weight can also lower your body’s resistance to insulin. […] You may need to take medicine called metformin. It reduces the amount of sugar made by the liver in people who are insulin-resistant.

• #34 Prediabetes diagnosis and treatment: A review

  https://pmc.ncbi.nlm.nih.gov/articles/PMC4360422/

  The encompassing theme of lifestyle intervention programs is to change the modifiable risk factors of prediabetes and diabetes by targeting obesity with increase in physical activity and dietary changes. […] Metformin has been used for several decades for treatment of diabetes and has been noted to have additional favorable outcomes such as body mass index (BMI) reduction and improved cholesterol profile. […] The collective evidence of trials among subjects with IGT suggests a 45% risk reduction for development of type 2 diabetes. […] Overall, there are safety concerns for thiazolidinedione such as weight gain, liver toxicity, increased cardiovascular risk and possible link with bladder cancer which have limited the use of these mediations for treatment of prediabetes. […] Bariatric surgery was found to result in sustained weight loss (23.4% at 2 years and 16.1% at 10 years) and a 75% relative risk reduction of diabetes compared to controls.

• #35 Prediabetes: Is Medication Necessary for Managing It? | Vinmec

  https://www.vinmec.com/eng/blog/do-i-need-to-take-medication-if-i-have-pre-diabetes-en

  For prediabetic patients prescribed Metformin, the effective dosage ranges from 1,000mg to 2,000mg daily. However, starting with a low dose is crucial for the body to adapt gradually. The recommended approach is to begin with 500mg/day for the first week, increase by 500mg/day in the second week, and, if necessary, add another 500mg/day in the third week until reaching the desired effect. […] Metformin has proven to be highly effective for prediabetes management. Compared to newer drugs, it offers several advantages: it is cost-effective, safer, and does not cause hypoglycemia, a common complication in diabetes patients. […] Metformin (commonly known as Glucophage) can also reduce the risk of developing diabetes. It may enhance the benefits of weight loss and exercise, making it a valuable complementary option for patients.

• #36 Prevention or Delay of Type 2 Diabetes Mellitus: Recommendations From the American Diabetes Association | AAFP

  https://www.aafp.org/pubs/afp/issues/2022/0400/p438.html

  Although weight loss is considered the most important factor for lowering the risk of type 2 diabetes, achieving the physical activity goal of at least 150 minutes per week can reduce diabetes incidence by 44% without weight loss. […] Medications can delay or prevent type 2 diabetes but are less effective than lifestyle programs. Metformin has the strongest evidence, whereas liraglutide, insulin, thiazolidinediones, alpha-glucosidase inhibitors, orlistat (Xenical), and phentermine/topiramate (Qsymia) all have some evidence of benefit. […] In patients with previous gestational diabetes, metformin reduces diabetes incidence by 50%, equivalent to lifestyle changes. […] Although evidence is limited, annual laboratory monitoring is recommended for patients with prediabetes to track treatment effectiveness and the development of type 2 diabetes.

• #37 Anticipating Tomorrow: Advances in Prediabetes Treatment

  https://www.delveinsight.com/blog/prediabetes-treatment

  Metformin functions as an antihyperglycemic agent, enhancing glucose tolerance in individuals with prediabetes or type 2 diabetes by reducing both basal and postprandial plasma glucose levels. […] Commonly utilized thiazolidinediones for prediabetes treatment encompass troglitazone, pioglitazone, rosiglitazone, and others. […] Another category of medications prescribed for prediabetes treatment includes orally administered GLP-1 analogs, which elicit a two- to three-fold increase in plasma insulin response compared to the same level of hyperglycemia induced by intravenous glucose. […] The next category of medication for prediabetes treatment involves DPP-IV inhibitors, exemplified by vildagliptin. […] Lastly, alpha-glucosidase inhibitors, sometimes termed starch blockers, function as antidiabetic medications that reduce postmeal blood glucose levels.

• #38 Prediabetes diagnosis and treatment: A review

  https://pmc.ncbi.nlm.nih.gov/articles/PMC4360422/

  The encompassing theme of lifestyle intervention programs is to change the modifiable risk factors of prediabetes and diabetes by targeting obesity with increase in physical activity and dietary changes. […] Metformin has been used for several decades for treatment of diabetes and has been noted to have additional favorable outcomes such as body mass index (BMI) reduction and improved cholesterol profile. […] The collective evidence of trials among subjects with IGT suggests a 45% risk reduction for development of type 2 diabetes. […] Overall, there are safety concerns for thiazolidinedione such as weight gain, liver toxicity, increased cardiovascular risk and possible link with bladder cancer which have limited the use of these mediations for treatment of prediabetes. […] Bariatric surgery was found to result in sustained weight loss (23.4% at 2 years and 16.1% at 10 years) and a 75% relative risk reduction of diabetes compared to controls.

• #39 Anticipating Tomorrow: Advances in Prediabetes Treatment

  https://www.delveinsight.com/blog/prediabetes-treatment

  Metformin functions as an antihyperglycemic agent, enhancing glucose tolerance in individuals with prediabetes or type 2 diabetes by reducing both basal and postprandial plasma glucose levels. […] Commonly utilized thiazolidinediones for prediabetes treatment encompass troglitazone, pioglitazone, rosiglitazone, and others. […] Another category of medications prescribed for prediabetes treatment includes orally administered GLP-1 analogs, which elicit a two- to three-fold increase in plasma insulin response compared to the same level of hyperglycemia induced by intravenous glucose. […] The next category of medication for prediabetes treatment involves DPP-IV inhibitors, exemplified by vildagliptin. […] Lastly, alpha-glucosidase inhibitors, sometimes termed starch blockers, function as antidiabetic medications that reduce postmeal blood glucose levels.

• #40

  https://link.springer.com/article/10.1007/s13300-023-01449-7

  Prediabetes is not independently associated with cardiovascular disease; the other factors in the metabolic syndrome increase that risk. […] Pharmacological treatment of the dysglycemia of prediabetes temporarily lowers glycemia but when the drugs are discontinued, development of diabetes is the same as in people who received placebos. […] The only effective treatment of prediabetes is significant weight loss, but this is very difficult to achieve, and especially to maintain, by nutritional means. […] High doses of glucagon-like peptide (GLP)-1 receptor agonists and combination of GLP-1 and glucose-dependent insulinotropic polypeptide (GIP) lower weight by 15% and 20%, respectively, and should be considered for treatment of prediabetes. […] Given the inability of lifestyle interventions outside of research studies to produce and maintain enough weight loss to accomplish this, weight loss drugs are currently the only effective option. […] These drug effects on weight loss are very impressive and will be effective in delaying and possibly preventing the development of diabetes in people with prediabetes.

• #41 Anticipating Tomorrow: Advances in Prediabetes Treatment

  https://www.delveinsight.com/blog/prediabetes-treatment

  Metformin functions as an antihyperglycemic agent, enhancing glucose tolerance in individuals with prediabetes or type 2 diabetes by reducing both basal and postprandial plasma glucose levels. […] Commonly utilized thiazolidinediones for prediabetes treatment encompass troglitazone, pioglitazone, rosiglitazone, and others. […] Another category of medications prescribed for prediabetes treatment includes orally administered GLP-1 analogs, which elicit a two- to three-fold increase in plasma insulin response compared to the same level of hyperglycemia induced by intravenous glucose. […] The next category of medication for prediabetes treatment involves DPP-IV inhibitors, exemplified by vildagliptin. […] Lastly, alpha-glucosidase inhibitors, sometimes termed starch blockers, function as antidiabetic medications that reduce postmeal blood glucose levels.

• #42 Anticipating Tomorrow: Advances in Prediabetes Treatment

  https://www.delveinsight.com/blog/prediabetes-treatment

  Metformin functions as an antihyperglycemic agent, enhancing glucose tolerance in individuals with prediabetes or type 2 diabetes by reducing both basal and postprandial plasma glucose levels. […] Commonly utilized thiazolidinediones for prediabetes treatment encompass troglitazone, pioglitazone, rosiglitazone, and others. […] Another category of medications prescribed for prediabetes treatment includes orally administered GLP-1 analogs, which elicit a two- to three-fold increase in plasma insulin response compared to the same level of hyperglycemia induced by intravenous glucose. […] The next category of medication for prediabetes treatment involves DPP-IV inhibitors, exemplified by vildagliptin. […] Lastly, alpha-glucosidase inhibitors, sometimes termed starch blockers, function as antidiabetic medications that reduce postmeal blood glucose levels.

• #43 Prevention or Delay of Type 2 Diabetes Mellitus: Recommendations From the American Diabetes Association | AAFP

  https://www.aafp.org/pubs/afp/issues/2022/0400/p438.html

  Although weight loss is considered the most important factor for lowering the risk of type 2 diabetes, achieving the physical activity goal of at least 150 minutes per week can reduce diabetes incidence by 44% without weight loss. […] Medications can delay or prevent type 2 diabetes but are less effective than lifestyle programs. Metformin has the strongest evidence, whereas liraglutide, insulin, thiazolidinediones, alpha-glucosidase inhibitors, orlistat (Xenical), and phentermine/topiramate (Qsymia) all have some evidence of benefit. […] In patients with previous gestational diabetes, metformin reduces diabetes incidence by 50%, equivalent to lifestyle changes. […] Although evidence is limited, annual laboratory monitoring is recommended for patients with prediabetes to track treatment effectiveness and the development of type 2 diabetes.

• #44

  https://link.springer.com/article/10.1007/s13300-023-01449-7

  Prediabetes is not independently associated with cardiovascular disease; the other factors in the metabolic syndrome increase that risk. […] Pharmacological treatment of the dysglycemia of prediabetes temporarily lowers glycemia but when the drugs are discontinued, development of diabetes is the same as in people who received placebos. […] The only effective treatment of prediabetes is significant weight loss, but this is very difficult to achieve, and especially to maintain, by nutritional means. […] High doses of glucagon-like peptide (GLP)-1 receptor agonists and combination of GLP-1 and glucose-dependent insulinotropic polypeptide (GIP) lower weight by 15% and 20%, respectively, and should be considered for treatment of prediabetes. […] Given the inability of lifestyle interventions outside of research studies to produce and maintain enough weight loss to accomplish this, weight loss drugs are currently the only effective option. […] These drug effects on weight loss are very impressive and will be effective in delaying and possibly preventing the development of diabetes in people with prediabetes.

• #45 Prediabetes Management

  https://www.uspharmacist.com/article/prediabetes-management-44469

  As opposed to behavioral modification, pharmacologic therapy with antidiabetics achieves a uniform reduction in the IGT and IFG conversion to T2DM. […] Metformin reduces the FPG and A1C and has been proven to be safe by trial evidence, showing only mild gastrointestinal (GI) effects and no serious adverse effects. […] There are no established doses for the use of antidiabetic drugs in the treatment of prediabetes.

• #46 Prediabetes diagnosis and treatment: A review

  https://www.wjgnet.com/1948-9358/full/v6/i2/296.htm

  Bariatric surgery was found to result in sustained weight loss (23.4% at 2 years and 16.1% at 10 years) and a 75% relative risk reduction of diabetes compared to controls. […] The rationale behind treatment of prediabetes includes, prevention of development of diabetes, prevention of consequences of diabetes and prevention of the consequences of prediabetes itself. […] While, the current evidence suggests efficacy of several treatment modalities regarding prevention of progression to diabetes, the long term benefits on microvascular or macrovascular complications remains debatable. […] Lifestyle interventions remain an essential part of management of prediabetes. […] The use of pharmacotherapy should be on an individual case based approach. […] A cautious approach is warranted for used of pharmacotherapy in children and youth.

• #47 Medication for Prediabetes – Lark Health Blog

  https://www.lark.com/resources/medication-for-prediabetes

  You are more likely to be prescribed metformin for prediabetes if your body mass index (BMI) is over 35, if you had gestational diabetes (diabetes that came during pregnancy and then left), or you are younger than 60 years old. Your doctor may also ask you to consider metformin if lifestyle changes have not worked to bring down your blood sugar levels. […] Medications for prediabetes are a strategy that can help, but they are more effective with lifestyle treatments, and may not even be necessary.

• #48 Prediabetes: Is Medication Necessary for Managing It? | Vinmec

  https://www.vinmec.com/eng/blog/do-i-need-to-take-medication-if-i-have-pre-diabetes-en

  Prediabetes is a health condition that can be improved and returned to normal through early intervention in lifestyle and daily activities. Drug intervention to treat prediabetes can be indicated for certain conditions when dietary and lifestyle adjustments are ineffective or ineffective. […] Currently, some patients with prediabetes take medication along with changes in their diet and daily exercise routine. The only medication currently recognized by the Ministry of Health as beneficial for treating prediabetes is Metformin. Medication is prescribed to prediabetes patients who have one or more of the following risk factors: failure to adjust diet and lifestyle over a long period, low HDL cholesterol, high triglycerides, or a family history of diabetes or obesity. This medication should only be prescribed by an endocrinologist, who will provide guidance on its proper use. Patients should not purchase or use it on their own.

• #49 Prediabetes Is on the Rise—But It Can Be Reversed > News > Yale Medicine

  https://www.yalemedicine.org/news/prediabetes

  If adults and children have difficulty changing lifestyle habits themselves, there are options, including a variety of types of weight-loss surgery (which in itself has been shown to reverse type 2 diabetes) and medications. […] Some doctors prescribe metformin, a front-line medication for type 2 diabetes, off-label for prediabetes (meaning doctors prescribe it for a condition even though the Food and Drug Administration [FDA] hasnt specifically approved it for that condition). Metformin is a good tool, Dr. Anam says, adding that studies have shown the drug can decrease the risk of progression to type 2 diabetes, although to a lesser degree than lifestyle changes. […] Whats important to remember is that prediabetes may be reversed, explains Dr. Anam. Ive had patients achieve tremendous things, she says, adding that starting early helps.

• #50 Prevention or Delay of Type 2 Diabetes Mellitus: Recommendations From the American Diabetes Association | AAFP

  https://www.aafp.org/pubs/afp/issues/2022/0400/p438.html

  Prediabetes is not a diagnosis but rather an opportunity to prevent or delay a future diagnosis of type 2 diabetes. […] Intensive lifestyle programs are the most effective intervention for preventing or delaying a diagnosis of diabetes in patients with prediabetes. […] In patients with prediabetes, metformin therapy will slow the progression to type 2 diabetes, although less effectively than lifestyle programs over time. […] In patients who have had gestational diabetes, the benefits of metformin therapy are similar to those of lifestyle programs. […] Strong evidence supports lifestyle interventions to delay or prevent diabetes. Programs that include diet, weight loss, and exercise reduce type 2 diabetes diagnoses by up to 58% over three years. […] Programs should be modeled after the National Diabetes Prevention Program, which targets sustained weight loss of at least 7% of body weight and at least 150 minutes of moderate-intensity exercise weekly.

• #51 Prevention or Delay of Type 2 Diabetes Mellitus: Recommendations From the American Diabetes Association | AAFP

  https://www.aafp.org/pubs/afp/issues/2022/0400/p438.html

  Prediabetes is not a diagnosis but rather an opportunity to prevent or delay a future diagnosis of type 2 diabetes. […] Intensive lifestyle programs are the most effective intervention for preventing or delaying a diagnosis of diabetes in patients with prediabetes. […] In patients with prediabetes, metformin therapy will slow the progression to type 2 diabetes, although less effectively than lifestyle programs over time. […] In patients who have had gestational diabetes, the benefits of metformin therapy are similar to those of lifestyle programs. […] Strong evidence supports lifestyle interventions to delay or prevent diabetes. Programs that include diet, weight loss, and exercise reduce type 2 diabetes diagnoses by up to 58% over three years. […] Programs should be modeled after the National Diabetes Prevention Program, which targets sustained weight loss of at least 7% of body weight and at least 150 minutes of moderate-intensity exercise weekly.

• #52 Prevention or Delay of Type 2 Diabetes Mellitus: Recommendations From the American Diabetes Association | AAFP

  https://www.aafp.org/pubs/afp/issues/2022/0400/p438.html

  Although weight loss is considered the most important factor for lowering the risk of type 2 diabetes, achieving the physical activity goal of at least 150 minutes per week can reduce diabetes incidence by 44% without weight loss. […] Medications can delay or prevent type 2 diabetes but are less effective than lifestyle programs. Metformin has the strongest evidence, whereas liraglutide, insulin, thiazolidinediones, alpha-glucosidase inhibitors, orlistat (Xenical), and phentermine/topiramate (Qsymia) all have some evidence of benefit. […] In patients with previous gestational diabetes, metformin reduces diabetes incidence by 50%, equivalent to lifestyle changes. […] Although evidence is limited, annual laboratory monitoring is recommended for patients with prediabetes to track treatment effectiveness and the development of type 2 diabetes.

• #53 Prevention or Delay of Type 2 Diabetes Mellitus: Recommendations From the American Diabetes Association | AAFP

  https://www.aafp.org/pubs/afp/issues/2022/0400/p438.html

  Prediabetes is not a diagnosis but rather an opportunity to prevent or delay a future diagnosis of type 2 diabetes. […] Intensive lifestyle programs are the most effective intervention for preventing or delaying a diagnosis of diabetes in patients with prediabetes. […] In patients with prediabetes, metformin therapy will slow the progression to type 2 diabetes, although less effectively than lifestyle programs over time. […] In patients who have had gestational diabetes, the benefits of metformin therapy are similar to those of lifestyle programs. […] Strong evidence supports lifestyle interventions to delay or prevent diabetes. Programs that include diet, weight loss, and exercise reduce type 2 diabetes diagnoses by up to 58% over three years. […] Programs should be modeled after the National Diabetes Prevention Program, which targets sustained weight loss of at least 7% of body weight and at least 150 minutes of moderate-intensity exercise weekly.

• #54 What is prediabetes? And what can you do about it? | UCLA Health

  https://www.uclahealth.org/news/article/what-is-prediabetes-and-what-can-you-do-about-it

  If you are overweight or obese and have prediabetes and participate in this structured lifestyle program, you can cut your risk of developing type 2 diabetes by more than half, Dr. Moin says. We know this program works. […] The Diabetes Prevention Program is so effective because participants are supported by science-backed curriculum led by a health coach. […] Another intervention available for overweight individuals with prediabetes is a drug called metformin. […] CDC studies show that metformin lowered the risk of prediabetes developing into type 2 diabetes by about 33%. […] For most adults with prediabetes, losing weight is key to normalizing blood-sugar levels even if the weight loss isn’t sustained long term. […] This is one instance where we can be proactive, Dr. Moin says. Making lifestyle changes exercising, eating healthier, getting more activity lowers your chance of getting type 2 diabetes and improves your quality of life.

• #55 Prediabetes treatment – Diabetes Canada

  https://www.diabetes.ca/about-diabetes/prediabetes/treatment

  Prediabetes is a precursor for type 2 diabetes. […] The good news is that more than half of people with prediabetes can delay or prevent the onset of type 2 diabetes. Taking steps now to improve your lifestyle can make a huge difference and lead to a healthier future. […] If you’ve been diagnosed with prediabetes, reduce your risk of developing type 2 diabetes by: following a health-promoting dietary pattern (see Canada’s Food Guide), exercising regularly (start slowly and increase to 150 minutes per week), discussing weight management with your healthcare provider. […] Healthy choices are vital to managing prediabetes and preventing type 2 diabetes. […] Diabetes Canada is here to help provide information and support so that you can live a healthy life. You may also talk to your healthcare team about support and services available in your community, such as: prediabetes education or diabetes prevention program, registered dietitian, exercise specialist, goal-setting. […] A 12-month, digital coaching program that empowers you to lead a healthier life and reduce your risk of developing Type 2 diabetes.

• #56 Prediabetes diagnosis and treatment options | Norton Healthcare

  https://nortonhealthcare.com/services-and-conditions/endocrinology-diabetes/services/prediabetes/

  Take Charge of Your Health! […] This online, self-driven educational program designed to support you in learning about and potentially reversing prediabetes. […] The good news is that prediabetes can be managed and sometimes reversed with lifestyle modifications — including a healthy diet, weight loss and exercising for 30 minutes a day, five days a week. […] If you’ve been diagnosed with prediabetes or would like to get screened, your primary care provider at Norton Community Medical Associates can help you create a personalized treatment plan. […] Managing prediabetes involves establishing a healthy lifestyle to improve insulin sensitivity, control blood sugar levels and reduce the risk of developing Type 2 diabetes. […] A healthy lifestyle can have a significant impact on managing prediabetes and reducing your risk of progressing to Type 2 diabetes. The time it takes to reverse prediabetes can vary widely depending on individual factors such as genetics, overall health and the extent of lifestyle changes implemented. However, significant improvements often can be seen within a few months.

• #57 Effectiveness of a cognitive behavioral therapy-integrated, hospital-based program for prediabetes: a matched cohort study | Scientific Reports

  https://www.nature.com/articles/s41598-024-58739-8

  Therefore, it is recommended to incorporate CBT with dietary and physical activity interventions to enhance and widen the adoption of healthy lifestyles in those with prediabetes. […] This study showed that a comprehensive hospital-based program providing dietary, physical activity, and psychological support combined with proactive outpatient care promotes weight loss, improves glycemic and lipid levels, and reduces diabetes rates. […] Our findings indicate that a hospital-based diabetes prevention program incorporating cognitive behavioral therapy can significantly reduce the long-term incidence of diabetes in individuals with prediabetes.

• #58 Effectiveness of a cognitive behavioral therapy-integrated, hospital-based program for prediabetes: a matched cohort study | Scientific Reports

  https://www.nature.com/articles/s41598-024-58739-8

  Therefore, it is recommended to incorporate CBT with dietary and physical activity interventions to enhance and widen the adoption of healthy lifestyles in those with prediabetes. […] This study showed that a comprehensive hospital-based program providing dietary, physical activity, and psychological support combined with proactive outpatient care promotes weight loss, improves glycemic and lipid levels, and reduces diabetes rates. […] Our findings indicate that a hospital-based diabetes prevention program incorporating cognitive behavioral therapy can significantly reduce the long-term incidence of diabetes in individuals with prediabetes.

• #59 Prediabetes Causes, Symptoms, and Treatments | UPMC

  https://www.upmc.com/services/endocrinology/conditions/prediabetes

  Prediabetes treatments focus on diet and lifestyle changes. Depending on your health and risk factors, your doctor may also suggest medicines or weight loss surgery. […] At UPMC, we have a team-based approach to prediabetes education and care. We aim to provide tailored treatment for prediabetes with the support and tools you need to stay healthy. […] Long-term lifestyle changes can help you lose weight and keep it off. […] You may reverse prediabetes by losing 5 to 7% of your starting weight with these techniques: […] Most people don’t need medicines for prediabetes. […] But based on your health history and risk factors, your doctor may suggest: […] Weight loss or bariatric surgery may reverse prediabetes if you are extremely overweight. […] This surgery is effective for people who can’t lose weight and keep it off with diet and lifestyle.

• #60 Prediabetes diagnosis and treatment: A review

  https://pmc.ncbi.nlm.nih.gov/articles/PMC4360422/

  The encompassing theme of lifestyle intervention programs is to change the modifiable risk factors of prediabetes and diabetes by targeting obesity with increase in physical activity and dietary changes. […] Metformin has been used for several decades for treatment of diabetes and has been noted to have additional favorable outcomes such as body mass index (BMI) reduction and improved cholesterol profile. […] The collective evidence of trials among subjects with IGT suggests a 45% risk reduction for development of type 2 diabetes. […] Overall, there are safety concerns for thiazolidinedione such as weight gain, liver toxicity, increased cardiovascular risk and possible link with bladder cancer which have limited the use of these mediations for treatment of prediabetes. […] Bariatric surgery was found to result in sustained weight loss (23.4% at 2 years and 16.1% at 10 years) and a 75% relative risk reduction of diabetes compared to controls.

• #61 Prediabetes Causes, Symptoms, and Treatments | UPMC

  https://www.upmc.com/services/endocrinology/conditions/prediabetes

  Prediabetes treatments focus on diet and lifestyle changes. Depending on your health and risk factors, your doctor may also suggest medicines or weight loss surgery. […] At UPMC, we have a team-based approach to prediabetes education and care. We aim to provide tailored treatment for prediabetes with the support and tools you need to stay healthy. […] Long-term lifestyle changes can help you lose weight and keep it off. […] You may reverse prediabetes by losing 5 to 7% of your starting weight with these techniques: […] Most people don’t need medicines for prediabetes. […] But based on your health history and risk factors, your doctor may suggest: […] Weight loss or bariatric surgery may reverse prediabetes if you are extremely overweight. […] This surgery is effective for people who can’t lose weight and keep it off with diet and lifestyle.

• #62 Prediabetes Is on the Rise—But It Can Be Reversed > News > Yale Medicine

  https://www.yalemedicine.org/news/prediabetes

  If adults and children have difficulty changing lifestyle habits themselves, there are options, including a variety of types of weight-loss surgery (which in itself has been shown to reverse type 2 diabetes) and medications. […] Some doctors prescribe metformin, a front-line medication for type 2 diabetes, off-label for prediabetes (meaning doctors prescribe it for a condition even though the Food and Drug Administration [FDA] hasnt specifically approved it for that condition). Metformin is a good tool, Dr. Anam says, adding that studies have shown the drug can decrease the risk of progression to type 2 diabetes, although to a lesser degree than lifestyle changes. […] Whats important to remember is that prediabetes may be reversed, explains Dr. Anam. Ive had patients achieve tremendous things, she says, adding that starting early helps.

• #63 Prediabetes: Symptoms, Diagnosis and Treatment | Banner Health

  https://www.bannerhealth.com/services/diabetes/prediabetes

  Eat healthy: Eat healthy foods like fruits, vegetables, whole grains, lean proteins and healthy fats. Drink plenty of water and limit added sugars and processed foods. […] Exercise daily: Exercise helps your body use more glucose, which may lower your blood sugar. Aim for 30 minutes a day of moderate physical activity. Your provider can guide you on a safe exercise plan. […] Regularly check your blood sugar: Your provider will check your blood sugar levels regularly. You may also need to check it at home with a glucose meter tool. […] Get to and maintain a healthy weight: Gaining too much weight or gaining weight too fast can make it harder to manage your blood sugar. If you are overweight, even a small weight loss (about 5% to 10% of your body weight) can reduce the risk of developing diabetes.

• #64 Prevention or Delay of Type 2 Diabetes Mellitus: Recommendations From the American Diabetes Association | AAFP

  https://www.aafp.org/pubs/afp/issues/2022/0400/p438.html

  Although weight loss is considered the most important factor for lowering the risk of type 2 diabetes, achieving the physical activity goal of at least 150 minutes per week can reduce diabetes incidence by 44% without weight loss. […] Medications can delay or prevent type 2 diabetes but are less effective than lifestyle programs. Metformin has the strongest evidence, whereas liraglutide, insulin, thiazolidinediones, alpha-glucosidase inhibitors, orlistat (Xenical), and phentermine/topiramate (Qsymia) all have some evidence of benefit. […] In patients with previous gestational diabetes, metformin reduces diabetes incidence by 50%, equivalent to lifestyle changes. […] Although evidence is limited, annual laboratory monitoring is recommended for patients with prediabetes to track treatment effectiveness and the development of type 2 diabetes.

• #65 Diabetes

  https://www.nhs.uk/conditions/diabetes/

  Many people have blood sugar levels above the normal range, but not high enough to be diagnosed as having diabetes. This is known as non-diabetic hyperglycaemia, or pre-diabetes. […] People with non-diabetic hyperglycaemia are at greater risk of developing type 2 diabetes, but the risk can be reduced through lifestyle changes. […] If you have non-diabetic hyperglycaemia, you may be eligible for the NHS Diabetes Prevention Programme. The programme helps people make lasting lifestyle changes and has been shown to help prevent type 2 diabetes. […] People with non-diabetic hyperglycaemia are also recommended to have a blood test every year to monitor their blood sugar levels. […] However, some people can put their type 2 diabetes into remission by losing weight, where their blood sugar is reduced below the diabetes range. Some people are able to do this through a low-calorie diet, but this is not suitable for everyone, so it’s important to get medical advice first.

• #66 Diabetes

  https://www.nhs.uk/conditions/diabetes/

  Many people have blood sugar levels above the normal range, but not high enough to be diagnosed as having diabetes. This is known as non-diabetic hyperglycaemia, or pre-diabetes. […] People with non-diabetic hyperglycaemia are at greater risk of developing type 2 diabetes, but the risk can be reduced through lifestyle changes. […] If you have non-diabetic hyperglycaemia, you may be eligible for the NHS Diabetes Prevention Programme. The programme helps people make lasting lifestyle changes and has been shown to help prevent type 2 diabetes. […] People with non-diabetic hyperglycaemia are also recommended to have a blood test every year to monitor their blood sugar levels. […] However, some people can put their type 2 diabetes into remission by losing weight, where their blood sugar is reduced below the diabetes range. Some people are able to do this through a low-calorie diet, but this is not suitable for everyone, so it’s important to get medical advice first.

• #67 Prediabetes: Symptoms, Diagnosis and Treatment | Banner Health

  https://www.bannerhealth.com/services/diabetes/prediabetes

  Quit smoking: Smoking may increase insulin resistance and the risk of type 2 diabetes in people with prediabetes. […] Take Medication: If diet and exercise alone aren’t enough to control your blood sugar, your provider may prescribe medications to help manage it. […] Have regular check-ups: Keep up with your medical appointments. Regular check-ups allow your care team to see how you are doing and adjust your treatment plan as needed.

• #68 Prediabetes Causes, Symptoms, and Treatments | UPMC

  https://www.upmc.com/services/endocrinology/conditions/prediabetes

  Prediabetes treatments focus on diet and lifestyle changes. Depending on your health and risk factors, your doctor may also suggest medicines or weight loss surgery. […] At UPMC, we have a team-based approach to prediabetes education and care. We aim to provide tailored treatment for prediabetes with the support and tools you need to stay healthy. […] Long-term lifestyle changes can help you lose weight and keep it off. […] You may reverse prediabetes by losing 5 to 7% of your starting weight with these techniques: […] Most people don’t need medicines for prediabetes. […] But based on your health history and risk factors, your doctor may suggest: […] Weight loss or bariatric surgery may reverse prediabetes if you are extremely overweight. […] This surgery is effective for people who can’t lose weight and keep it off with diet and lifestyle.

• #69 Prediabetes treatment – Diabetes Canada

  https://www.diabetes.ca/about-diabetes/prediabetes/treatment

  Prediabetes is a precursor for type 2 diabetes. […] The good news is that more than half of people with prediabetes can delay or prevent the onset of type 2 diabetes. Taking steps now to improve your lifestyle can make a huge difference and lead to a healthier future. […] If you’ve been diagnosed with prediabetes, reduce your risk of developing type 2 diabetes by: following a health-promoting dietary pattern (see Canada’s Food Guide), exercising regularly (start slowly and increase to 150 minutes per week), discussing weight management with your healthcare provider. […] Healthy choices are vital to managing prediabetes and preventing type 2 diabetes. […] Diabetes Canada is here to help provide information and support so that you can live a healthy life. You may also talk to your healthcare team about support and services available in your community, such as: prediabetes education or diabetes prevention program, registered dietitian, exercise specialist, goal-setting. […] A 12-month, digital coaching program that empowers you to lead a healthier life and reduce your risk of developing Type 2 diabetes.

• #70 Prevention or Delay of Type 2 Diabetes Mellitus: Recommendations From the American Diabetes Association | AAFP

  https://www.aafp.org/pubs/afp/issues/2022/0400/p438.html

  Prediabetes is not a diagnosis but rather an opportunity to prevent or delay a future diagnosis of type 2 diabetes. […] Intensive lifestyle programs are the most effective intervention for preventing or delaying a diagnosis of diabetes in patients with prediabetes. […] In patients with prediabetes, metformin therapy will slow the progression to type 2 diabetes, although less effectively than lifestyle programs over time. […] In patients who have had gestational diabetes, the benefits of metformin therapy are similar to those of lifestyle programs. […] Strong evidence supports lifestyle interventions to delay or prevent diabetes. Programs that include diet, weight loss, and exercise reduce type 2 diabetes diagnoses by up to 58% over three years. […] Programs should be modeled after the National Diabetes Prevention Program, which targets sustained weight loss of at least 7% of body weight and at least 150 minutes of moderate-intensity exercise weekly.

• #71 Prevention or Delay of Type 2 Diabetes Mellitus: Recommendations From the American Diabetes Association | AAFP

  https://www.aafp.org/pubs/afp/issues/2022/0400/p438.html

  Although weight loss is considered the most important factor for lowering the risk of type 2 diabetes, achieving the physical activity goal of at least 150 minutes per week can reduce diabetes incidence by 44% without weight loss. […] Medications can delay or prevent type 2 diabetes but are less effective than lifestyle programs. Metformin has the strongest evidence, whereas liraglutide, insulin, thiazolidinediones, alpha-glucosidase inhibitors, orlistat (Xenical), and phentermine/topiramate (Qsymia) all have some evidence of benefit. […] In patients with previous gestational diabetes, metformin reduces diabetes incidence by 50%, equivalent to lifestyle changes. […] Although evidence is limited, annual laboratory monitoring is recommended for patients with prediabetes to track treatment effectiveness and the development of type 2 diabetes.

• #72 Prediabetes – Your Chance to Prevent Type 2 Diabetes | Diabetes | CDC

  https://www.cdc.gov/diabetes/prevention-type-2/prediabetes-prevent-type-2.html

  If you have prediabetes, the CDC-led National Diabetes Prevention Program lifestyle change program can help. When you join, you’ll learn to make lifestyle changes that lower your risk and improve your health. […] If you have prediabetes, you can lower your risk for developing type 2 diabetes by: Losing a small amount of weight if you have overweight. Getting regular physical activity. […] The CDC-led National Diabetes Prevention Program can help you make those changes and make them stick. Through the program, you can lower your risk for type 2 diabetes by 58% (71% if you’re over age 60).

• #73 What is prediabetes? And what can you do about it? | UCLA Health

  https://www.uclahealth.org/news/article/what-is-prediabetes-and-what-can-you-do-about-it

  If you are overweight or obese and have prediabetes and participate in this structured lifestyle program, you can cut your risk of developing type 2 diabetes by more than half, Dr. Moin says. We know this program works. […] The Diabetes Prevention Program is so effective because participants are supported by science-backed curriculum led by a health coach. […] Another intervention available for overweight individuals with prediabetes is a drug called metformin. […] CDC studies show that metformin lowered the risk of prediabetes developing into type 2 diabetes by about 33%. […] For most adults with prediabetes, losing weight is key to normalizing blood-sugar levels even if the weight loss isn’t sustained long term. […] This is one instance where we can be proactive, Dr. Moin says. Making lifestyle changes exercising, eating healthier, getting more activity lowers your chance of getting type 2 diabetes and improves your quality of life.

• #74 Prediabetes diagnosis and treatment: A review

  https://pmc.ncbi.nlm.nih.gov/articles/PMC4360422/

  The encompassing theme of lifestyle intervention programs is to change the modifiable risk factors of prediabetes and diabetes by targeting obesity with increase in physical activity and dietary changes. […] Metformin has been used for several decades for treatment of diabetes and has been noted to have additional favorable outcomes such as body mass index (BMI) reduction and improved cholesterol profile. […] The collective evidence of trials among subjects with IGT suggests a 45% risk reduction for development of type 2 diabetes. […] Overall, there are safety concerns for thiazolidinedione such as weight gain, liver toxicity, increased cardiovascular risk and possible link with bladder cancer which have limited the use of these mediations for treatment of prediabetes. […] Bariatric surgery was found to result in sustained weight loss (23.4% at 2 years and 16.1% at 10 years) and a 75% relative risk reduction of diabetes compared to controls.

• #75 Prediabetes: Which Treatment Should I Use to Prevent Type 2 Diabetes? | Kaiser Permanente

  https://healthy.kaiserpermanente.org/health-wellness/health-encyclopedia/he.prediabetes-which-treatment-should-i-use-to-prevent-type-2-diabetes.abp5563

  Some people may choose to take metformin and also make major lifestyle changes. Doing both of these things may give you the best chance of delaying or preventing type 2 diabetes over the long term. […] Lifestyle changes can help you lower blood sugar and prevent type 2 diabetes. […] Metformin can help you lower blood sugar and prevent type 2 diabetes. […] Metformin is easy for some people to use. All you do is take medicine every day. But it is still important to make lifestyle changes if you can. […] Making major lifestyle changes or taking metformin both work better than a placebo pill at delaying or preventing type 2 diabetes. […] The American Diabetes Association (ADA) recommends making major lifestyle changes. […] The ADA also suggests taking metformin, especially if you’re younger than 60, have a body mass index (BMI) of 35 or more, or have had gestational diabetes.

• #76 Prediabetes: Which Treatment Should I Use to Prevent Type 2 Diabetes? | Kaiser Permanente

  https://healthy.kaiserpermanente.org/health-wellness/health-encyclopedia/he.prediabetes-which-treatment-should-i-use-to-prevent-type-2-diabetes.abp5563

  Some people may choose to take metformin and also make major lifestyle changes. Doing both of these things may give you the best chance of delaying or preventing type 2 diabetes over the long term. […] Lifestyle changes can help you lower blood sugar and prevent type 2 diabetes. […] Metformin can help you lower blood sugar and prevent type 2 diabetes. […] Metformin is easy for some people to use. All you do is take medicine every day. But it is still important to make lifestyle changes if you can. […] Making major lifestyle changes or taking metformin both work better than a placebo pill at delaying or preventing type 2 diabetes. […] The American Diabetes Association (ADA) recommends making major lifestyle changes. […] The ADA also suggests taking metformin, especially if you’re younger than 60, have a body mass index (BMI) of 35 or more, or have had gestational diabetes.

• #77 Prediabetes: Causes, Symptoms, and Treatment

  https://www.webmd.com/diabetes/what-is-prediabetes

  Prediabetes treatment can prevent more serious health problems, including type 2 diabetes and problems with your heart, blood vessels, eyes, and kidneys. […] The main treatment for prediabetes is a healthy lifestyle that includes these steps: Eat a healthy diet. Lose weight if you need to. Exercise regularly. Stop smoking. Get your blood pressure and cholesterol under control. […] If you’re at high risk of diabetes, your doctor might also suggest you take medication such as metformin (Glucophage) to lower your blood sugar. […] The same healthy lifestyle habits that treat prediabetes can help prevent it.

• #78 Prediabetes – Symptoms and causes – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/prediabetes/symptoms-causes/syc-20355278

  Reversing insulin resistance and preventing type two diabetes is possible through lifestyle changes, medication, or sometimes both. […] Eating healthy foods, making physical activity part of your daily routine and staying at a healthy weight can help bring your blood sugar level back to normal. […] Healthy lifestyle choices can help you prevent prediabetes and its progression to type 2 diabetes even if diabetes runs in your family. These include: Eating healthy foods, Getting active, Losing excess weight, Controlling your blood pressure and cholesterol, Not smoking.

• #79 Prediabetes treatment may reduce heart and kidney risks in childhood cancer survivors – St. Jude Children’s Research Hospital

  https://www.stjude.org/media-resources/news-releases/2023-medicine-science-news/prediabetes-treatment-may-reduce-heart-kidney-risks-in-childhood-cancer-survivors.html

  The findings suggest that even small increases in blood sugar levels should be taken as a sign to start lifestyle interventions in survivors to protect their hearts and kidneys. […] We need to help survivors understand that prediabetes is really an early warning sign that says you need to do something, whether thats changing lifestyle, starting medication or following up with primary care, Dixon said. […] The findings showed survivors with diabetes are at twice the risk of a heart attack event compared to those with normal blood sugar levels. […] The researchers observed a three times greater risk of chronic kidney disease in survivors with prediabetes or diabetes. […] We should be considering interventions to mitigate risk in this population of prediabetic and diabetic survivors so they can live longer, healthier lives, Dixon said.

• #80 Prediabetes Diagnosis and Treatment in Primary Care | American Board of Family Medicine

  https://www.jabfm.org/content/29/2/283

  Background: The increasing prevalence of diabetes is a major health problem. The detection and treatment of prediabetes can delay the onset of diabetes and presents an important diabetes prevention strategy. […] Once detected, prediabetes should be acknowledged with a treatment plan (metformin or intense lifestyle intervention) to prevent or slow the transition to diabetes. […] Indication of treatment in the medical record (lifestyle modification counseling and/or metformin) was present in 23.0% of those with diagnosed or undiagnosed prediabetes. The most common treatment was lifestyle modification counseling. […] Our findings show that there are missed opportunities for diabetes prevention in primary care. Providers need to change their approach to prediabetes and play a more effective role in preventing diabetes.

• #81 Prediabetes Diagnosis and Treatment in Primary Care | American Board of Family Medicine

  https://www.jabfm.org/content/29/2/283

  This lack of diagnosis should be considered in light of the fact that the most common primary diagnosis for that visit was hypertension, a common comorbid condition with diabetes. […] The finding that most patients with confirmed prediabetes do not receive appropriate care suggests that the approach of primary care toward prediabetes needs to change if we are to effectively prevent diabetes.

• #82

  https://link.springer.com/article/10.1007/s11606-020-06354-4

  Over one third of American adults are at high risk for developing diabetes, which can be delayed or prevented using interventions such as medical nutrition therapy (MNT) or metformin. […] To characterize treatment of prediabetes in primary care. […] We collected patient characteristics and the following treatments: metformin prescription; referral to MNT, diabetes education, endocrinology, or bariatric medicine; and MNT visit. […] Of 16,713 outpatients with prediabetes, 20.4% received treatment, including metformin prescriptions (7.8%) and MNT referrals (11.3%), but only 7.4% of referred patients completed a MNT visit. […] Almost 80% of patients with new prediabetes never received treatment, and those who did receive referrals had very poor visit completion. Treatment rates appear to reflect provider rather than patient preferences.

• #83

  https://link.springer.com/article/10.1007/s11606-020-06354-4

  Clinical guidelines recommend low-risk, low-cost interventions including medical nutrition therapy (MNT), exercise, and metformin in order to delay or prevent progression to diabetes, but clinical uptake is uncertain. […] In a recent survey of physicians, 67% reported recommending MNT to at least some patients, and national visit-level data indicate that diet is discussed at less than a fifth of visits and metformin is prescribed at less than 3%. […] An American Diabetes Association (ADA) Consensus Report recommends that all overweight or obese patients with prediabetes be referred to intensive lifestyle intervention such as a DPP or MNT with a nutritionist or registered dietitian. […] Our primary outcome was any attempt at treating prediabetes, including a prescription for metformin or referral to any of the following: MNT, diabetes education, endocrinology consultation, and bariatric medicine consultation.

• #84

  https://link.springer.com/article/10.1007/s11606-020-06354-4

  Clinical guidelines recommend low-risk, low-cost interventions including medical nutrition therapy (MNT), exercise, and metformin in order to delay or prevent progression to diabetes, but clinical uptake is uncertain. […] In a recent survey of physicians, 67% reported recommending MNT to at least some patients, and national visit-level data indicate that diet is discussed at less than a fifth of visits and metformin is prescribed at less than 3%. […] An American Diabetes Association (ADA) Consensus Report recommends that all overweight or obese patients with prediabetes be referred to intensive lifestyle intervention such as a DPP or MNT with a nutritionist or registered dietitian. […] Our primary outcome was any attempt at treating prediabetes, including a prescription for metformin or referral to any of the following: MNT, diabetes education, endocrinology consultation, and bariatric medicine consultation.

• #85

  https://link.springer.com/article/10.1007/s11606-020-06354-4

  Clinical guidelines recommend low-risk, low-cost interventions including medical nutrition therapy (MNT), exercise, and metformin in order to delay or prevent progression to diabetes, but clinical uptake is uncertain. […] In a recent survey of physicians, 67% reported recommending MNT to at least some patients, and national visit-level data indicate that diet is discussed at less than a fifth of visits and metformin is prescribed at less than 3%. […] An American Diabetes Association (ADA) Consensus Report recommends that all overweight or obese patients with prediabetes be referred to intensive lifestyle intervention such as a DPP or MNT with a nutritionist or registered dietitian. […] Our primary outcome was any attempt at treating prediabetes, including a prescription for metformin or referral to any of the following: MNT, diabetes education, endocrinology consultation, and bariatric medicine consultation.

• #86

  https://link.springer.com/article/10.1007/s13300-023-01449-7

  Prediabetes is not independently associated with cardiovascular disease; the other factors in the metabolic syndrome increase that risk. […] Pharmacological treatment of the dysglycemia of prediabetes temporarily lowers glycemia but when the drugs are discontinued, development of diabetes is the same as in people who received placebos. […] The only effective treatment of prediabetes is significant weight loss, but this is very difficult to achieve, and especially to maintain, by nutritional means. […] High doses of glucagon-like peptide (GLP)-1 receptor agonists and combination of GLP-1 and glucose-dependent insulinotropic polypeptide (GIP) lower weight by 15% and 20%, respectively, and should be considered for treatment of prediabetes. […] Given the inability of lifestyle interventions outside of research studies to produce and maintain enough weight loss to accomplish this, weight loss drugs are currently the only effective option. […] These drug effects on weight loss are very impressive and will be effective in delaying and possibly preventing the development of diabetes in people with prediabetes.

• #87 Prediabetes Diagnosis: Helpful or Harmful? | AAFP

  https://www.aafp.org/pubs/afp/issues/2021/1200/p649.html

  A diagnosis of questionable clinical significance could cause psychological distress and lead to additional testing, overtreatment, increased physician visits, and financial hardship. […] The use of metformin for prediabetes reduces the conversion to diabetes over three years (number needed to treat = 14). […] However, the cost and feasibility of prolonged weight loss coaching are questionable. […] The Centers for Disease Control and Prevention’s (CDC’s) National Diabetes Prevention Program states that people with prediabetes who take part in a structured lifestyle change program can cut their risk of developing type 2 diabetes by 58% (71% for people over 60 years old). […] There is no evidence that treating prediabetes with medications decreases mortality, macrovascular complications, or significant microvascular complications. […] Counseling patients about a healthy diet, physical activity, and weight loss for those who are overweight is worthwhile whether or not a patient is diagnosed with prediabetes.

• #88

  https://link.springer.com/article/10.1007/s11606-020-06354-4

  Patients who received a prediabetes diagnostic code were more likely to receive treatment than those who remained undiagnosed (23.9% vs. 10.8%, p0.001). […] Of 1881 (11.3%) patients who received MNT referrals, 140 (7.4%) completed at least one visit. Thus, less than 1% of patients with prediabetes visited a nutritionist. […] The strong association of metformin prescription with HbA1c may reflect PCPs simply treating higher prediabetes-range HbA1c as almost diabetic. […] More than 15 years ago, the Diabetes Prevention Program (DPP) study demonstrated that diabetes could be prevented through diet and exercise or metformin. […] Low rates of treatment could be attributed to individual PCPs, who varied widely in their propensity to treat and to get their patients to complete a MNT visit. […] New quality measures might incentivize treatment for prediabetes, and widespread reimbursement for MNT and healthcare-initiated MNT coordination might improve visit completion.

• #89

  https://link.springer.com/article/10.1007/s11606-020-06354-4

  Patients who received a prediabetes diagnostic code were more likely to receive treatment than those who remained undiagnosed (23.9% vs. 10.8%, p0.001). […] Of 1881 (11.3%) patients who received MNT referrals, 140 (7.4%) completed at least one visit. Thus, less than 1% of patients with prediabetes visited a nutritionist. […] The strong association of metformin prescription with HbA1c may reflect PCPs simply treating higher prediabetes-range HbA1c as almost diabetic. […] More than 15 years ago, the Diabetes Prevention Program (DPP) study demonstrated that diabetes could be prevented through diet and exercise or metformin. […] Low rates of treatment could be attributed to individual PCPs, who varied widely in their propensity to treat and to get their patients to complete a MNT visit. […] New quality measures might incentivize treatment for prediabetes, and widespread reimbursement for MNT and healthcare-initiated MNT coordination might improve visit completion.

• #90 Prevention or Delay of Type 2 Diabetes Mellitus: Recommendations From the American Diabetes Association | AAFP

  https://www.aafp.org/pubs/afp/issues/2022/0400/p438.html

  Prediabetes is not a diagnosis but rather an opportunity to prevent or delay a future diagnosis of type 2 diabetes. […] Intensive lifestyle programs are the most effective intervention for preventing or delaying a diagnosis of diabetes in patients with prediabetes. […] In patients with prediabetes, metformin therapy will slow the progression to type 2 diabetes, although less effectively than lifestyle programs over time. […] In patients who have had gestational diabetes, the benefits of metformin therapy are similar to those of lifestyle programs. […] Strong evidence supports lifestyle interventions to delay or prevent diabetes. Programs that include diet, weight loss, and exercise reduce type 2 diabetes diagnoses by up to 58% over three years. […] Programs should be modeled after the National Diabetes Prevention Program, which targets sustained weight loss of at least 7% of body weight and at least 150 minutes of moderate-intensity exercise weekly.

• #91

  https://www.healio.com/news/endocrinology/20120325/experts-recommend-two-pronged-approach-to-treating-prediabetes

  According to the most recent data compiled by the CDC, 57 million U.S. adults have prediabetes, a figure that has reached pandemic levels. […] In an ideal world, you want to diagnose high-risk people early in order to prevent progression to full-blown diabetes and its associated complications, Glenn Matfin, MD, clinical associate professor at New York University and senior staff physician at the Joslin Diabetes Center, told Endocrine Today. […] To examine the current state of prediabetes treatment, Endocrine Today spoke with a number of experts to best understand how lifestyle and pharmacological approaches should be utilized to reverse glucose functions to normal levels. […] The ACE/AACE consensus statement recommends a two-pronged approach to treating prediabetes: intensive lifestyle intervention, followed by the prevention of CV complications using CV risk reduction medications for abnormal blood pressure and cholesterol, independent of glucose control medications.

• #92 Prevention or Delay of Type 2 Diabetes Mellitus: Recommendations From the American Diabetes Association | AAFP

  https://www.aafp.org/pubs/afp/issues/2022/0400/p438.html

  Although weight loss is considered the most important factor for lowering the risk of type 2 diabetes, achieving the physical activity goal of at least 150 minutes per week can reduce diabetes incidence by 44% without weight loss. […] Medications can delay or prevent type 2 diabetes but are less effective than lifestyle programs. Metformin has the strongest evidence, whereas liraglutide, insulin, thiazolidinediones, alpha-glucosidase inhibitors, orlistat (Xenical), and phentermine/topiramate (Qsymia) all have some evidence of benefit. […] In patients with previous gestational diabetes, metformin reduces diabetes incidence by 50%, equivalent to lifestyle changes. […] Although evidence is limited, annual laboratory monitoring is recommended for patients with prediabetes to track treatment effectiveness and the development of type 2 diabetes.

• #93 Prediabetes: Which Treatment Should I Use to Prevent Type 2 Diabetes? | Kaiser Permanente

  https://healthy.kaiserpermanente.org/health-wellness/health-encyclopedia/he.prediabetes-which-treatment-should-i-use-to-prevent-type-2-diabetes.abp5563

  Some people may choose to take metformin and also make major lifestyle changes. Doing both of these things may give you the best chance of delaying or preventing type 2 diabetes over the long term. […] Lifestyle changes can help you lower blood sugar and prevent type 2 diabetes. […] Metformin can help you lower blood sugar and prevent type 2 diabetes. […] Metformin is easy for some people to use. All you do is take medicine every day. But it is still important to make lifestyle changes if you can. […] Making major lifestyle changes or taking metformin both work better than a placebo pill at delaying or preventing type 2 diabetes. […] The American Diabetes Association (ADA) recommends making major lifestyle changes. […] The ADA also suggests taking metformin, especially if you’re younger than 60, have a body mass index (BMI) of 35 or more, or have had gestational diabetes.

• #94 Type 2 Diabetes Mellitus Treatment & Management: Approach Considerations, Pharmacologic Therapy, Management of Glycemia

  https://emedicine.medscape.com/article/117853-treatment

  Prediabetes […] The American Diabetes Association (ADA) released condensed recommendations for Standards of Medical Care in Diabetes: Abridged for Primary Care Providers, highlighting recommendations most relevant to primary care. The abridged version focuses particularly on the following aspects: Prediabetes, Self-management education, Nutrition, Physical activity, Smoking cessation, Psychosocial care, Immunizations, Glycemic treatment, Therapeutic targets, Diagnosis and treatment of vascular complications, Intensification of insulin therapy in type 2 diabetes. […] The prediabetes section of the algorithm considers cardiovascular risk factors and the options of antihyperglycemic or antiobesity therapy, though without making a recommendation regarding which form of treatment is better. […] The ADA recommends that, in addition to lifestyle counseling, metformin be considered in selected patients with prediabetes.

• #95

  https://www.healio.com/news/endocrinology/20120325/experts-recommend-two-pronged-approach-to-treating-prediabetes

  According to the most recent data compiled by the CDC, 57 million U.S. adults have prediabetes, a figure that has reached pandemic levels. […] In an ideal world, you want to diagnose high-risk people early in order to prevent progression to full-blown diabetes and its associated complications, Glenn Matfin, MD, clinical associate professor at New York University and senior staff physician at the Joslin Diabetes Center, told Endocrine Today. […] To examine the current state of prediabetes treatment, Endocrine Today spoke with a number of experts to best understand how lifestyle and pharmacological approaches should be utilized to reverse glucose functions to normal levels. […] The ACE/AACE consensus statement recommends a two-pronged approach to treating prediabetes: intensive lifestyle intervention, followed by the prevention of CV complications using CV risk reduction medications for abnormal blood pressure and cholesterol, independent of glucose control medications.

• #96

  https://www.healio.com/news/endocrinology/20120325/experts-recommend-two-pronged-approach-to-treating-prediabetes

  Guidelines from the American Diabetes Association (ADA) suggest that patients who are diagnosed with prediabetes be referred to an effective ongoing support program, with a weight loss goal of 5% to 10% of their current body weight, as well as a call for an increase in physical activity of at least 150 minutes per week of a moderate activity such as walking. […] Clinical data suggest that if a patient is able to adhere to it, then lifestyle intervention has broader benefits than drug therapies, and without the side effect profile, John B. Buse, MD, PhD, professor of medicine and endocrinology chief at the University of North Carolina, Chapel Hill, told Endocrine Today. […] For some physicians, lifestyle change is just one aspect of prediabetes treatment. […] The ACE/AACE prediabetes consensus statement recommends that lipid and BP goals be the same for those with prediabetes as those with full-blown diabetes.

• #97 Recommendation: Prediabetes and Type 2 Diabetes: Screening | United States Preventive Services Taskforce

  https://www.uspreventiveservicestaskforce.org/uspstf/recommendation/screening-for-prediabetes-and-type-2-diabetes

  The USPSTF recommends screening for prediabetes and type 2 diabetes in adults aged 35 to 70 years who have overweight or obesity. Clinicians should offer or refer patients with prediabetes to effective preventive interventions. […] Both lifestyle interventions that focus on diet, physical activity, or both and metformin have demonstrated efficacy in preventing or delaying progression to diabetes in persons with prediabetes. […] The Diabetes Prevention Program (DPP) study (which serves as a model for many lifestyle intervention programs in the US), lifestyle intervention was more effective than metformin in preventing or delaying diabetes. […] The USPSTF recognizes that clinical decisions involve more considerations than evidence alone. Clinicians should understand the evidence but individualize decision making to the specific patient or situation.

• #98 Recommendation: Prediabetes and Type 2 Diabetes: Screening | United States Preventive Services Taskforce

  https://www.uspreventiveservicestaskforce.org/uspstf/recommendation/screening-for-prediabetes-and-type-2-diabetes

  The USPSTF has made a recommendation on behavioral weight loss interventions to prevent obesity-related morbidity and mortality in adults with a BMI 30. […] The USPSTF concludes with moderate certainty that screening for prediabetes and type 2 diabetes and offering or referring patients with prediabetes to effective preventive interventions has a moderate net benefit.

• #99 Recommendation: Prediabetes and Type 2 Diabetes: Screening | United States Preventive Services Taskforce

  https://www.uspreventiveservicestaskforce.org/uspstf/recommendation/screening-for-prediabetes-and-type-2-diabetes

  The USPSTF has made a recommendation on behavioral weight loss interventions to prevent obesity-related morbidity and mortality in adults with a BMI 30. […] The USPSTF concludes with moderate certainty that screening for prediabetes and type 2 diabetes and offering or referring patients with prediabetes to effective preventive interventions has a moderate net benefit.

• #100 Prediabetes Education & Treatments: Steps to Prevent Type 2 Diabetes

  https://diabetes.org/about-diabetes/prediabetes

  For some people with prediabetes, early treatment as well as moderate lifestyle changes can actually return blood glucose (blood sugar) levels to a normal range, effectively preventing or delaying type 2 diabetes. […] If you discover that you do have prediabetes, remember that it doesnt mean youll develop type 2, particularly if you follow a treatment plan and make changes to your lifestyle through food choices and physical activity. […] A CDC-recognized lifestyle change program could cut your risk of developing type 2 diabetes in half. […] With prediabetes, there are simple steps you can take to change things, such as adapting your food choices and increasing your daily physical activity to lose weight, if needed. […] Take steps to prevent or delay the onset of type 2 diabetes.

• #101 Prediabetes: Diagnosis & Treatment | NewYork-Presbyterian

  https://www.nyp.org/primary-care/prediabetes/treatment

  Prediabetes is reversible. Implementing dietary and lifestyle changes can help normalize blood sugar levels and lower your risk of developing type 2 diabetes. Your doctor can also recommend medications that can decrease your risk for progression to diabetes. In general, however, physicians do not prescribe medications for prediabetes alone. […] Prediabetes treatment includes adopting a healthier routine to reduce your blood sugar levels and risk factors for developing type 2 diabetes. This includes maintaining a healthy weight, quitting smoking, avoiding heavy alcohol consumption, and exercising regularly. […] If dietary and lifestyle changes aren’t helping to reduce your blood sugar levels, and you are at risk for developing type 2 diabetes, your doctor may prescribe medication to delay the progression to diabetes. This could include drugs such as metformin or weight loss medications. […] NewYork-Presbyterian is home to compassionate primary care physicians who are familiar with the care of patients with prediabetes. We’re here to support you in reversing prediabetes and preventing type 2 diabetes.

• #102 Prediabetes: Which Treatment Should I Use To Prevent Type 2 Diabetes? – Health Library | NewYork-Presbyterian

  https://www.nyp.org/healthlibrary/decisions/prediabetes-which-treatment-should-i-use-to-prevent-type-2-diabetes

  For many people, making major lifestyle changes works better than taking metformin to help delay or prevent type 2 diabetes for up to 10 years. […] For some people, making major lifestyle changes or taking metformin can help delay or prevent type 2 diabetes for up to 15 years. […] Some people may choose to take metformin and also make major lifestyle changes. Doing both of these things may give you the best chance of delaying or preventing type 2 diabetes over the long term. […] The American Diabetes Association (ADA) recommends making major lifestyle changes. […] The ADA also suggests taking metformin, especially if you’re younger than 60, have a body mass index (BMI) of 35 or more, or have had gestational diabetes. […] The ADA recommends that you and your doctor talk about the benefits and risks of making lifestyle changes or using metformin to prevent type 2 diabetes and to make a decision based on your personal preferences and overall health.

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