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• #1 Acute lymphoblastic leukaemia | NHS inform

  https://www.nhsinform.scot/illnesses-and-conditions/cancer/cancer-types-in-adults/acute-lymphoblastic-leukaemia/

  Symptoms of acute lymphoblastic leukaemia usually begin slowly before rapidly getting severe as the number of immature white blood cells in your blood increases. Symptoms include: pale skin, tiredness, breathlessness, having repeated infections over a short space of time, unusual and frequent bleeding. […] Symptoms of acute lymphoblastic leukaemia usually begin slowly before rapidly getting severe as the number of blast cells (immature white blood cells) in your blood increases. Most of the symptoms are caused by the lack of healthy blood cells in your blood supply. Symptoms of acute lymphoblastic leukaemia include: pale skin, feeling tired and breathless, having repeated infections over a short space of time, unusual and frequent bleeding, such as bleeding gums or nose bleeds, high temperature (fever) of 38C (100.4F) or above, night sweats, bone and joint pain, easily bruised skin, swollen lymph nodes (glands), abdominal pain caused by a swollen liver or spleen, unexplained weight loss, a purple skin rash (purpura).

• #1 Signs and Symptoms of Acute Lymphocytic Leukemia (ALL) | American Cancer Society

  https://www.cancer.org/cancer/types/acute-lymphocytic-leukemia/detection-diagnosis-staging/signs-symptoms.html

  Acute lymphocytic leukemia (ALL) can cause many different signs and symptoms. Most of these occur in all kinds of ALL, but some are more common with certain subtypes of ALL. […] Most signs and symptoms of ALL are the result of shortages of normal blood cells, which happen when the leukemia cells crowd out the normal blood-making cells in the bone marrow. These shortages show up on blood tests, but they can also cause symptoms, including: Feeling tired, Feeling weak, Feeling dizzy or lightheaded, Shortness of breath, Pale skin, Infections that dont go away or keep coming back, Bruises (or small red or purple spots) on the skin, Bleeding, such as frequent or severe nosebleeds, bleeding gums, or heavy menstrual bleeding in women. […] Patients with ALL also often have several non-specific symptoms. These can include: Weight loss, Fever, Night sweats, Loss of appetite.

• #1 Acute lymphocytic leukemia – Symptoms and causes – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/acute-lymphocytic-leukemia/symptoms-causes/syc-20369077

  Acute lymphocytic leukemia (ALL) is a type of cancer of the blood and bone marrow the spongy tissue inside bones where blood cells are made. […] The word „acute” in acute lymphocytic leukemia comes from the fact that the disease progresses rapidly and creates immature blood cells, rather than mature ones. […] Signs and symptoms of acute lymphocytic leukemia may include: Bleeding from the gums, Bone pain, Fever, Frequent infections, Frequent or severe nosebleeds, Lumps caused by swollen lymph nodes in and around the neck, armpits, abdomen or groin, Pale skin, Shortness of breath, Weakness, fatigue or a general decrease in energy. […] Many signs and symptoms of acute lymphocytic leukemia mimic those of the flu. However, flu signs and symptoms eventually improve. If signs and symptoms don’t improve as expected, make an appointment with your doctor.

• #1 Symptoms of acute lymphoblastic leukaemia (ALL) | Cancer Research UK

  https://www.cancerresearchuk.org/about-cancer/acute-lymphoblastic-leukaemia-all/symptoms

  Symptoms of ALL can be similar to those caused by other illnesses. You may only have one or some of these symptoms if you have ALL. […] The symptoms are caused by having too many abnormal white blood cells and not enough normal white blood cells, red blood cells and platelets. […] Common symptoms of ALL include: feeling weak or tired, shortness of breath, pale skin, a high temperature or fever, picking up or not being able to shake off infections easily, bruising and bleeding easily, swelling of your lymph nodes, pain in your bones or joints, feeling full or pain in your tummy (abdomen), weight loss. […] You might feel more tired and weaker than normal, even when you are getting a good night’s sleep. This is called fatigue. This can happen if you have a low number of red blood cells.

• #1 Leukemia Symptoms | Learn The Signs Of Leukemia | LLS

  https://www.lls.org/leukemia/acute-lymphoblastic-leukemia/signs-and-symptoms

  Signs and symptoms are changes in the body that may indicate disease. A person who has signs or symptoms that suggest the possibility of leukemia is usually referred to a specialist. It is common for someone with ALL to feel a loss of well-being because of the underproduction of normal blood cells. Consequently, patients with ALL do not have sufficient numbers of mature red blood cells, white blood cells and platelets. […] Symptoms of anemia (low red blood cell count) include Fatigue, Shortness of breath during normal physical activities, Dizziness, Pale complexion. […] Symptoms of neutropenia (low number of neutrophils, a type of white blood cells) include Frequent infections, Fever. […] Symptoms of thrombocytopenia (low platelet count) include Bruising easily, Prolonged bleeding from minor cuts, The appearance of pinhead-sized red spots on the skin, called petechiae, Frequent or severe nosebleeds, Bleeding gums, Heavier or more frequent menstrual periods.

• #1 Acute Lymphoblastic Leukemia (ALL): Symptoms, Treatment & Prognosis

  https://my.clevelandclinic.org/health/diseases/21564-acute-lymphocytic-leukemia

  Most ALL symptoms come on suddenly and affect children and adults similarly. Common initial symptoms include: Anemia. Bleeding, such as frequent nosebleeds or heavy menstrual periods. Bruising. Cough. Dizziness. Fatigue. Fever. Frequent viral infections or bacterial infections. Joint pain. Loss of appetite. Night sweats. Red, pinhead-sized spots on your skin (petechiae). Shortness of breath. Skin color that’s paler or lighter than usual. Swollen lymph nodes. Unexplained weight loss. Weakness. […] Many acute lymphoblastic leukemia symptoms mimic other less serious conditions. Having one or more of the symptoms listed above isn’t a sign that you have ALL. In general, you should talk to a healthcare provider about changes in your body that last more than two weeks. […] ALL affects your lymphocytes, a type of white blood cell that helps your body fight viruses and bacteria. Normally, your bone marrow produces immature white blood cells (lymphoblasts) that mature into healthy lymphocytes. In ALL, leukemic lymphoblasts never mature. Instead, they multiply, crowding out other blood cells and platelets before moving from your bone marrow to your bloodstream and then to other areas of your body. As a result, your platelet levels are low and you’re likely to bruise more easily, bleed more than usual or develop anemia.

• #1 Azthena logo with the word Azthena

  https://www.news-medical.net/health/Acute-Lymphoblastic-Leukemia-Symptoms.aspx

  Acute lymphoblastic leukemia most commonly affects children below 15 years of age. It is rare among adults. The symptoms are usually slow in onset but may rapidly get severe as the number of immature white blood cells (blast cells) rises and overcrowd other cells in the blood. […] The symptoms of ALL are indicative of the underlying pathology of the cancer. The symptoms of ALL include:- Pallor the skin and mucus membranes are pale. This is the hallmark sign of anemia. Due to the rise in number of blast cells in blood the red blood cells are lowered in number and this may result in anemia. […] Tiredness and fatigue are symptoms that are associated with anemia and are seen commonly in ALL patients. […] There may be breathlessness, palpitations and easy fatigability due to anemia and inadequate oxygenation.

• #1 Acute Lymphocytic Leukemia (ALL): Symptoms, Risks, and Survival Rates

  https://www.healthline.com/health/acute-lymphocytic-leukemia-all

  Having ALL increases your chances of bleeding and developing infections. The symptoms and signs of ALL may also include: paleness (pallor) […] bleeding from the gums […] a fever […] bruises or purpura (bleeding within the skin) […] petechiae (red or purple spots on the body) […] lymphadenopathy (characterized by enlarged lymph nodes in the neck, under the arms, or in the groin region) […] enlarged liver […] enlarged spleen […] bone pain […] joint pain […] weakness […] fatigue […] shortness of breath […] testicular enlargement […] cranial nerve palsies. […] Your doctor must complete a full physical exam and conduct blood and bone marrow tests to diagnose ALL. They’ll likely ask about bone pain, since it’s one of the first symptoms of ALL. […] Chemotherapy is used to treat this type of leukemia. For the first treatment, you may have to stay in the hospital for a few weeks. Later, you may be able to continue treatment as an outpatient. […] Survival rates for adults aren’t as high as survival rates for children, but they’re steadily improving. […] Children with ALL stand a very good chance of being cured.

• #1 ALL Basics – What is Acute Lymphoblastic Leukemia | Sarah Cannon

  https://sarahcannon.com/for-patients/learn-about-cancer/blood-cancer/all/

  Acute lymphoblastic leukemia (ALL) is a cancer of the bone marrow and blood. This type of leukemia progresses rapidly without treatment and doesn’t have a known cause. ALL affects your blood cells and immune system. […] If you feel that you may be affected by ALL, talk to your doctor. Signs and symptoms include: Bruises for no clear reason, Prolonged bleeding from minor cuts, Aches in the arms, legs or back, Enlarged lymph nodes, Fever without an obvious cause or a lasting, low-grade fever, Headaches, Pale skin, Pinhead-size red spots under the skin, Shortness of breath during normal physical activity, Tiredness or no energy, Vomiting, Unexplained weight loss.

• #1 Symptoms of Acute Lymphoblastic Leukaemia (ALL) | Cancer Council NSW

  https://www.cancercouncil.com.au/acute-lymphoblastic-leukaemia/symptoms/

  Occasionally, a person will have no symptoms or vague symptoms such as an ongoing cold, and the leukaemia is discovered during a routine blood test. Usually, people with acute lymphoblastic leukaemia (ALL) find that some of the following symptoms appear quickly over a few weeks. […] Low levels of red blood cells (anaemia) can cause tiredness (fatigue), weakness, a pale complexion and breathlessness. […] Low platelet levels can cause bruising without a bump or fall, nosebleeds, bleeding gums, heavy periods, and small red or purple spots on the skin or mouth (called petechiae). […] A lack of normal white blood cells can cause mouth sores or ulcers, sore throats, fevers, sweats, coughing, boils, infected cuts or scratches, and frequent and painful passing of urine. A low white blood cell level can also lead to more serious infections.

• #1 Acute lymphoblastic leukaemia | Leukaemia & Blood Cancer New Zealand

  https://www.leukaemia.org.nz/information/about-blood-cancers/leukaemia/acute-lymphoblastic-leukaemia/

  Acute lymphoblastic leukaemia (ALL) is a type of cancer of the blood and bone marrow. ALL occurs when the bone marrow makes too many immature white blood cells, called lymphoblasts or leukaemic blasts. […] This type of leukaemia can appear suddenly and progress rapidly. […] Signs and symptoms of ALL will vary from person to person. It is common for someone with ALL to feel a loss of wellbeing because of the lack of normal, healthy blood cells. […] Common signs and symptoms of infection include: Fever (high temperature), Shivering or rigors, Coughing up yellow or green phlegm, Fatigue or extreme tiredness. […] Other symptoms of ALL include recurrent drenching night sweats, unexplained weight loss, loss of appetite, bone or joint pain, enlarged lymph nodes, and swelling and pain in the abdomen.

• #1 Signs and Symptoms of Acute Lymphocytic Leukemia (ALL) | American Cancer Society

  https://www.cancer.org/cancer/types/acute-lymphocytic-leukemia/detection-diagnosis-staging/signs-symptoms.html

  Leukemia cells may build up in the liver and spleen, making them larger. This might be noticed as a fullness or swelling of the belly, or feeling full after eating only a small amount. […] ALL that has spread to lymph nodes close to the surface of the body (such as on the sides of the neck, in the groin, or in underarm areas), might be noticed as lumps under the skin. […] Sometimes leukemia cells build up near the surface of the bone or inside the joint, which can lead to bone or joint pain. […] If ALL spreads to the brain and spinal cord it can cause headaches, weakness, seizures, vomiting, trouble with balance, facial muscle weakness or numbness, or blurred vision. […] The T-cell subtype of ALL often affects the thymus, which is a small organ in the middle of the chest behind the sternum (breastbone) and in front of the trachea (windpipe). An enlarged thymus can press on the trachea, which can lead to coughing or trouble breathing. […] If the thymus is enlarged, it may press on the SVC, causing the blood to back up in the veins. This is known as SVC syndrome. It can cause: Swelling in the face, neck, arms, and upper chest (sometimes with a bluish-red color), Headaches, Dizziness, Change in consciousness if it affects the brain.

• #1 Acute Lymphoblastic Leukemia Treatment – NCI

  https://www.cancer.gov/types/leukemia/patient/adult-all-treatment-pdq

  Acute lymphoblastic leukemia (ALL) is a type of cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell). […] Signs and symptoms of ALL include fatigue, fever, and easy bruising or bleeding. […] The early signs and symptoms of ALL may be like the flu or other common diseases. Check with your doctor if you have: weakness or fatigue, fever or drenching night sweats, easy bruising or bleeding, petechiae (flat, pinpoint spots under the skin, caused by bleeding), shortness of breath, weight loss or loss of appetite, pain in the bones or stomach, pain or feeling of fullness below the ribs, painless lumps in the neck, underarm, stomach, or groin, frequent infections. […] In ALL, too many stem cells become lymphoblasts, B lymphocytes, or T lymphocytes. These cells are also called leukemia cells. Leukemia cells are not able to fight infection very well. Also, as the number of leukemia cells increases in the blood and bone marrow, there is less room for healthy white blood cells, red blood cells, and platelets. This may cause infection, anemia, and easy bleeding. The cancer can also spread to the central nervous system (brain and spinal cord), lymph nodes, spleen, liver, testicles, and other organs. […] After ALL has been diagnosed, tests are done to find out if the cancer has spread to the central nervous system (brain and spinal cord) or to other parts of the body.

• #1 Symptoms of acute lymphoblastic leukaemia – NHS

  https://www.nhs.uk/conditions/acute-lymphoblastic-leukaemia/symptoms/

  Symptoms of acute lymphoblastic leukaemia (ALL) are not always obvious at first and can be similar to other conditions. […] They usually appear quite quickly over a few weeks. […] The main symptoms include: feeling tired or weak, bleeding or bruising easily or for no reason, looking more pale than usual, getting ill a lot or taking longer than usual to recover from illnesses, a high temperature, swollen glands (usually in the neck, armpits and groin), pain in the bones or joints, loss of appetite or losing weight without trying, shortness of breath, a swollen tummy your tummy may feel painful, uncomfortable or full. […] Less common symptoms include: a headache, being sick, blurred vision, fits (seizures), a cough, a swollen and red face, neck, arms or hands the redness may be harder to see on brown and black skin, swollen veins in the neck or chest.

• #1 Symptoms of acute lymphoblastic leukaemia (ALL) | Cancer Research UK

  https://www.cancerresearchuk.org/about-cancer/acute-lymphoblastic-leukaemia-all/symptoms

  You might feel breathless when doing your normal day to day activities or from climbing a short flight of stairs. […] You might look paler or more 'washed out’ than normal. […] You might have a high temperature or feel feverish. This could be due to an infection or caused by the ALL. […] You might pick up infections such as coughs and colds easily. […] You might have nosebleeds, bleeding gums when you clean your teeth, very heavy periods, small dark red, purple or brown spots on your skin that look like a rash. […] Your lymph nodes might feel swollen. […] You might feel pain in your bones or joints. This might be a dull ache or more of a stabbing pain. […] You might have a feeling of fullness or discomfort in your abdomen. […] You might lose weight even if you haven’t changed your diet. […] A type of leukaemia called T cell ALL can cause swollen lymph nodes in the centre of your chest. […] Go to the accident and emergency (AE) department at your nearest hospital if you have any of these symptoms. It can be a medical emergency.

• #1 Symptoms of childhood acute lymphoblastic leukaemia (ALL) | Cancer Research UK

  https://www.cancerresearchuk.org/about-cancer/childrens-cancer/acute-lymphoblastic-leukaemia/symptoms

  Your child might have bony pain. Children might limp or refuse to walk as they would normally. This pain is most common in the long bones in the body, like the arms or legs. But it can also affect the back and joints. […] Your child might go off their food. They might be eating smaller amounts or not wanting to eat even their favourite foods. […] Your child might have a feeling of fullness or discomfort in their tummy (abdomen). Your childs tummy might look bigger than normal, or you might notice they suddenly jump a nappy or trouser size. […] Boys might have testicular swelling in one or both testes. This is because the leukaemia cells can collect there. This is usually painless. […] Your child might seem particularly fractious or irritable and you might be finding it difficult to get them to settle.

• #1 Acute lymphoblastic leukaemia | NHS inform

  https://www.nhsinform.scot/illnesses-and-conditions/cancer/cancer-types-in-adults/acute-lymphoblastic-leukaemia/

  In some cases of acute lymphoblastic leukaemia, the affected cells can spread from your bloodstream into your central nervous system. This can cause a series of neurological symptoms (related to the brain and nervous system), including: headaches, seizures (fits), vomiting, blurred vision, dizziness. […] As the number of immature cells increases, the number of healthy red blood cells and platelets fall, and its this fall which causes many of the symptoms of leukaemia.

• #1 Symptoms of Acute Lymphoblastic Leukaemia (ALL) | Cancer Council NSW

  https://www.cancercouncil.com.au/acute-lymphoblastic-leukaemia/symptoms/

  When leukaemia causes a build-up of abnormal white blood cells, the lymph nodes and spleen can become swollen. An enlarged spleen can cause pain or discomfort in the abdomen or back. […] These include bone or joint pain, swollen and tender gums, skin rashes, headaches, weight loss, vision problems, vomiting and chest pains.

• #1 Acute lymphoblastic leukemia – Wikipedia

  https://en.wikipedia.org/wiki/Acute_lymphoblastic_leukemia

  Symptoms may include feeling tired, pale skin color, fever, easy bleeding or bruising, enlarged lymph nodes, or bone pain. […] As an acute leukemia, ALL progresses rapidly and is typically fatal within weeks or months if left untreated. […] The signs and symptoms of acute lymphoblastic leukemia are variable and include generalized weakness and feeling tired, anemia, dizziness, headache, vomiting, lethargy, neck stiffness, frequent or unexplained fever and infection, weight loss and/or loss of appetite, excessive and unexplained bruising, bone pain, joint pain, breathlessness, enlarged lymph nodes, liver, and/or spleen, pitting edema in the lower limbs and/or abdomen, petechiae, testicular enlargement, and mediastinal mass. […] Acute lymphoblastic leukemia results when enough of these genetic changes are present in a single lymphoblast. In childhood ALL, for example, one fusion gene translocation is often found along with six to eight other ALL-related genetic changes.

• #1 Acute Lymphoblastic Leukaemia (ALL): Signs & Treatments

  https://cfch.com.sg/acute-lymphoblastic-leukaemia-all/

  ALL is the most common type of cancer in children and accounts for 20% of blood cancers in adults. It is a type of blood cancer which leads to the overproduction of abnormal white blood cells called lymphoblasts. These lymphoblasts circulate in the bloodstream and infiltrate the bone marrow, lymph glands and other organs in the body. As a result, the normal function of the bone marrow is affected leading to poor production of red cells, normal white cells and platelets. If left untreated, it is usually fatal within 3 months of diagnosis. […] Signs & Symptoms of Acute Lymphoblastic Leukaemia (ALL) include fever, fatigue, bleeding symptoms, pale skin, weight loss, lymph node swelling, enlarged abdomen, and neurological impairment. […] Acute Lymphoblastic Leukaemia is an aggressive form of leukaemia. The overproduction of the abnormal white blood cells responsible for Acute Lymphoblastic Leukaemia can occur over several days or weeks.

• #1 Symptoms of childhood acute lymphoblastic leukaemia (ALL) | Cancer Research UK

  https://www.cancerresearchuk.org/about-cancer/childrens-cancer/acute-lymphoblastic-leukaemia/symptoms

  Childhood cancer is rare. Most children with one or more of these symptoms don’t have leukaemia. But it’s important to get your GP to check any of the symptoms out. […] Many symptoms of ALL are vague and non specific. They are similar to the symptoms of many more minor childhood illness. […] Symptoms of childhood ALL can include: looking pale, feeling very tired, bruising or bleeding easily or for no reason, having a high temperature (fever), picking up infections easily and often, swollen lymph nodes, bone pain, loss of appetite, swollen tummy (abdomen), swelling of one or both testicles. […] Not every child with ALL has all of these symptoms before they are diagnosed. […] At the beginning these symptoms might come and go. Your child might be exhausted one day, but brighter the next.

• #1 Acute lymphoblastic leukaemia | Leukaemia & Blood Cancer New Zealand

  https://www.leukaemia.org.nz/information/about-blood-cancers/leukaemia/acute-lymphoblastic-leukaemia/

  Without treatment, the bone marrow will produce increasing numbers of abnormal cells and the production of normal blood cells will keep reducing. A sharp reduction in the number of red blood cells in the blood causes anaemia and the shortage of normal white blood cells and platelets becomes more severe.

• #1 Disease progression of acute lymphoblastic leukemia | Canadian Cancer Society

  https://cancer.ca/en/cancer-information/cancer-types/acute-lymphoblastic-leukemia-all/disease-progression

  Cancer cells can spread from where they start to other parts of the body. Leukemia is a cancer of the blood-forming tissue in the bone marrow, and it can develop wherever the blood travels. As a result, acute lymphoblastic leukemia (ALL) is often widespread when it is found. […] Understanding how a type of cancer usually grows and spreads helps your healthcare team plan your treatment and future care. Leukemia cells usually collect in: the peripheral blood and bone marrow, the lymph nodes, the brain and spinal cord (called the central nervous system, or CNS), the liver, the spleen, a joint or along the surface of bones, the thymus often affected with T-cell ALL, the skin, testicles, kidneys or eyes (in rare cases). […] Leukemia does not usually form solid tumours in these organs. The buildup of abnormal cells in the organs affects them so they dont work normally.

• #1 Acute Lymphoblastic Leukemia – Seattle Children’s Hospital

  https://www.seattlechildrens.org/conditions/leukemia-all/

  Symptoms of ALL tend to appear over a matter of days or weeks and get worse quickly. Many of the signs and symptoms of ALL happen because cancer cells crowd out healthy blood cells or build up in the lymph nodes or other parts of the body. […] These symptoms may be caused by ALL or by another health problem. Check with a doctor if your child has: Fever, which may be a sign of infection; Easy bruising or bleeding, even from small injuries; Weakness, tiredness or feeling dizzy; Pinpoint spots of blood under the skin caused by tiny broken blood vessels; Bone or joint pain; Painless lumps in the neck, underarm, stomach, groin and around the eyes; Pain and fullness under the ribs; Loss of appetite; Shortness of breath or coughing; Headaches or problems with vision, balance or muscle control. […] In most children, leukemia grows fast and gets worse quickly without treatment. This is called acute.

• #1 Acute Lymphoblastic Leukemia (ALL): Symptoms, Treatment & Prognosis

  https://my.clevelandclinic.org/health/diseases/21564-acute-lymphocytic-leukemia

  Your prognosis is the outcome you may expect after treatment. ALL often goes into complete remission after chemotherapy that kills cancerous cells. In general, children and young adults have a better prognosis than do people age 20 and older. […] In some cases, yes, ALL can be cured. Children with ALL who remain in complete remission after five years are considered cured. That’s because ALL rarely recurs (comes back) after five years. Older children and adults with ALL are less likely to be cured because treatment doesn’t always put ALL into long-term remission.

• #1 Acute Lymphoblastic Leukemia (ALL) | Children’s Hospital of Philadelphia

  https://www.chop.edu/conditions-diseases/acute-lymphoblastic-leukemia-all

  Acute lymphoblastic leukemia (ALL), sometimes called acute lymphocytic leukemia, is the most common form of leukemia found in children, accounting for about 30 percent of all pediatric cancers. […] The most common signs and symptoms of acute lymphoblastic leukemia in children are: […] Anemia occurs when normal red blood cells can’t be produced because the bone marrow is overcrowded by leukemia cells. […] Bleeding and/or bruising. When the bone marrow cannot produce enough platelets, bleeding can occur, especially when the platelet numbers are less than 10-20,000/mm3. […] Pain in bones and joints is usually a result of the bone marrow being crowded with leukemic blasts. […] The child with leukemia often shows non-specific symptoms of infection such as fever and fatigue. […] Leukemia cells can collect in the kidneys, liver and spleen, causing enlargement of these organs which can cause pain in the abdomen. […] Lymph nodes filter the blood. Leukemia cells often collect in the nodes, causing swelling. […] In leukemia, especially T-cell ALL, cells can clump together in the thymus a gland under the breastbone and around the throat. This mass of cells can cause difficulty breathing.

• #1 Acute Lymphoblastic Leukemia (ALL) (for Parents) | Nemours KidsHealth

  https://kidshealth.org/en/parents/all.html

  Kids with ALL may get anemia, which is when the body has too few red blood cells. This happens when bone marrow stops making the usual amount of red blood cells. […] Kids with anemia may: look pale, feel very tired or weak, get short of breath while playing. […] When they don’t have enough platelets, kids with leukemia may bruise easily, get nosebleeds, or bleed for a long time after even a minor cut. […] Other symptoms of leukemia can include: pain in the bones or joints, sometimes causing a limp, swollen lymph nodes in the neck, groin, or elsewhere, poor appetite and weight loss, fevers, belly pain. […] Because their white blood cells can’t fight infections, kids with leukemia are more likely to get viral or bacterial infections. […] Sometimes leukemia can spread, or metastasize. If it spreads to the brain, symptoms may include headaches, seizures, balance problems, or vision problems. If it spreads to the lymph nodes in the chest, symptoms can include breathing problems and chest pain. […] Acute lymphoblastic leukemia develops and gets worse quickly, so early diagnosis is important. Most kids are cured with treatment.

• #1 Childhood Acute Lymphoblastic Leukemia (ALL) | Dana-Farber Cancer Institute

  https://www.dana-farber.org/cancer-care/types/childhood-acute-lymphoblastic-leukemia

  Acute lymphoblastic leukemia (ALL), also known as acute lymphocytic leukemia, is a quickly progressing disease in which too many abnormal white blood cells are found in the bone marrow (the soft, spongy center of long bones). […] Because leukemia is a cancer of the bone marrow, the initial symptoms often are related to abnormal bone marrow function. […] Some of the most common ALL symptoms include: Anemia: Leukemia frequently causes anemia (low red blood cell count) because the bone marrow becomes too crowded with leukemia cells to produce normal red blood cells. […] Bone and joint pain: Your child may experience pain in his bones and joints. […] Bruising or petechiae: When the marrow is too crowded to allow platelets to be produced, your child may bruise more easily. […] Fever: Many children with ALL have fevers that are not related to a specific infection, though sometimes fever at the time of diagnosis can be a sign of infection.

• #1 Acute Lymphoblastic Leukaemia (ALL) in Adults

  https://www.parkwaycancercentre.com/sg/learn-about-cancer/types-of-cancer/cancer-details/acute-lymphoblastic-leukaemia-(all)-in-adults

  Adult ALL may cause a variety of symptoms, which are mainly the result of having insufficient normal blood cells in the body. Common symptoms of Adult ALL are: […] Fatigue […] Fever […] Breathlessness […] Feeling weak […] Loss of appetite […] Weight loss […] Night sweats or excessive sweating […] Bleeding gums or nosebleeds […] Bruising easily […] Red or purple spots on the skin […] Bone or joint pain […] Feeling of fullness in the stomach or swollen stomach […] Painless lumps in the neck, underarm, stomach or groin […] Frequent infections.

• #1 Diagnosing Acute Lymphoblastic Leukemia | NYU Langone Health

  https://nyulangone.org/conditions/acute-lymphoblastic-leukemia/diagnosis

  The liver, which also filters blood, can become swollen as lymphoblasts collect there. […] A swollen spleen and liver may cause the abdomen to protrude. […] Lymphoblasts can also travel to the brain and spinal cord, causing symptoms such as headaches, seizures, or balance problems. […] Although the causes of acute lymphoblastic leukemia are not completely understood, the condition is more common in white men than in others. […] While the condition is more common in children, it can also occur in adults. […] The incidence of acute lymphoblastic leukemia after age 50 is rising. […] To diagnose the condition, a doctor asks about your medical history and symptoms. […] He or she may conduct a physical exam to check for swelling in the lymph nodes, liver, or spleen. […] Several tests can also aid in diagnosing the disease.

• #1 Reddit – The heart of the internet

  https://www.reddit.com/r/leukemia/comments/zob11a/how_fast_does_all_usually_move/

  My 13-year-old daughter just died in December 8 from ALL (specifically a brain stem hemorrhage due to thrombocytopenia due to acute lymphoblastic leukemia). […] There was no warning. On December 2, she and her brother woke up with fevers and headaches. […] She was healthy, full of energy, and didn’t have any of the symptoms listed on internet sites. […] Since her passing, we have learned of one other child who died suddenly of ALL and who displayed no symptoms or warning signs beforehand. […] Is this a very common thing, or is ALL usually detected in time to be treated?

• #1 Acute Lymphocytic Leukemia (ALL): Causes, Symptoms, and Treatment

  https://www.everydayhealth.com/leukemia/acute-lymphocytic-leukemia/guide/

  ALL symptoms happen because of a drop in healthy blood cells, according to the American Cancer Society. Which symptoms you have depends on the type of blood cell that’s affected. […] Symptoms of low red blood cells (anemia): Dizziness, Fatigue, Pale skin, Shortness of breath. […] Symptoms of low white blood cells: Fever, Infections that don’t go away or that keep coming back. […] Symptoms of low platelets: Bleeding gums, Easy bruising, Frequent or severe nosebleeds, Heavier-than-usual menstrual periods, Small red or purple spots on the skin (petechiae). […] ALL can also cause more body-wide symptoms, such as: Appetite loss, Belly pain, Bone or joint pain, Fever, Night sweats, Swollen lymph nodes, liver, or spleen, Unexplained weight loss.

• #1 Acute lymphoblastic leukaemia (ALL) – Leukaemia Foundation

  https://www.leukaemia.org.au/blood-cancer/types-of-blood-cancer/leukaemia/acute-lymphoblastic-leukaemia/

  Common symptoms of ALL can include: anaemia due to a lack of red cells. Anaemia can cause persistent tiredness, dizziness, paleness, or shortness of breath when physically active. frequent or repeated infections and slow healing, due to a lack of normal white cells, especially neutrophils. increased or unexplained bleeding or bruising, due to a very low platelet count. bone and/or joint pain as a result of the marrow being overcrowded with leukaemic cells. […] Other symptoms may include swollen lymph nodes (glands), chest pain and abdominal discomfort due to a swollen spleen or liver. […] Occasionally people have no symptoms and ALL is diagnosed during a routine blood test. Some of these symptoms described may also be seen in other illnesses, including viral infections, so it is important to see your doctor so that you can be examined and treated properly.

• #1 Leukemia Symptoms: Early Stage, Late Stage, Management Tips

  https://www.healthline.com/health/leukemia/leukemia-symptoms

  Symptoms of end stage leukemia can vary from person to person depending on the course of the disease and the leukemia subtype. End stage symptoms can potentially include: extreme tiredness and weakness, a need to rest or sleep all the time, extreme weight loss and loss of appetite, difficulty eating or drinking, changes in taste, trouble speaking, loss of ability to perform daily tasks, difficulty waking from sleep, hallucinations, low blood pressure, irregular heart rate, weak pulse, dark, bluish, or pale skin, loss of ability to regulate your bladder and bowels, loss of consciousness.

• #2 Acute Lymphocytic Leukemia (ALL): Symptoms, Risks, and Survival Rates

  https://www.healthline.com/health/acute-lymphocytic-leukemia-all

  Having ALL increases your chances of bleeding and developing infections. The symptoms and signs of ALL may also include: paleness (pallor) […] bleeding from the gums […] a fever […] bruises or purpura (bleeding within the skin) […] petechiae (red or purple spots on the body) […] lymphadenopathy (characterized by enlarged lymph nodes in the neck, under the arms, or in the groin region) […] enlarged liver […] enlarged spleen […] bone pain […] joint pain […] weakness […] fatigue […] shortness of breath […] testicular enlargement […] cranial nerve palsies. […] Your doctor must complete a full physical exam and conduct blood and bone marrow tests to diagnose ALL. They’ll likely ask about bone pain, since it’s one of the first symptoms of ALL. […] Chemotherapy is used to treat this type of leukemia. For the first treatment, you may have to stay in the hospital for a few weeks. Later, you may be able to continue treatment as an outpatient. […] Survival rates for adults aren’t as high as survival rates for children, but they’re steadily improving. […] Children with ALL stand a very good chance of being cured.

• #2 Symptoms of acute lymphoblastic leukaemia (ALL) | Cancer Research UK

  https://www.cancerresearchuk.org/about-cancer/acute-lymphoblastic-leukaemia-all/symptoms

  Symptoms of ALL can be similar to those caused by other illnesses. You may only have one or some of these symptoms if you have ALL. […] The symptoms are caused by having too many abnormal white blood cells and not enough normal white blood cells, red blood cells and platelets. […] Common symptoms of ALL include: feeling weak or tired, shortness of breath, pale skin, a high temperature or fever, picking up or not being able to shake off infections easily, bruising and bleeding easily, swelling of your lymph nodes, pain in your bones or joints, feeling full or pain in your tummy (abdomen), weight loss. […] You might feel more tired and weaker than normal, even when you are getting a good night’s sleep. This is called fatigue. This can happen if you have a low number of red blood cells.

• #2 Acute lymphoblastic leukaemia | NHS inform

  https://www.nhsinform.scot/illnesses-and-conditions/cancer/cancer-types-in-adults/acute-lymphoblastic-leukaemia/

  Symptoms of acute lymphoblastic leukaemia usually begin slowly before rapidly getting severe as the number of immature white blood cells in your blood increases. Symptoms include: pale skin, tiredness, breathlessness, having repeated infections over a short space of time, unusual and frequent bleeding. […] Symptoms of acute lymphoblastic leukaemia usually begin slowly before rapidly getting severe as the number of blast cells (immature white blood cells) in your blood increases. Most of the symptoms are caused by the lack of healthy blood cells in your blood supply. Symptoms of acute lymphoblastic leukaemia include: pale skin, feeling tired and breathless, having repeated infections over a short space of time, unusual and frequent bleeding, such as bleeding gums or nose bleeds, high temperature (fever) of 38C (100.4F) or above, night sweats, bone and joint pain, easily bruised skin, swollen lymph nodes (glands), abdominal pain caused by a swollen liver or spleen, unexplained weight loss, a purple skin rash (purpura).

• #2 Symptoms of acute lymphoblastic leukaemia (ALL) | Cancer Research UK

  https://www.cancerresearchuk.org/about-cancer/acute-lymphoblastic-leukaemia-all/symptoms

  You might feel breathless when doing your normal day to day activities or from climbing a short flight of stairs. […] You might look paler or more 'washed out’ than normal. […] You might have a high temperature or feel feverish. This could be due to an infection or caused by the ALL. […] You might pick up infections such as coughs and colds easily. […] You might have nosebleeds, bleeding gums when you clean your teeth, very heavy periods, small dark red, purple or brown spots on your skin that look like a rash. […] Your lymph nodes might feel swollen. […] You might feel pain in your bones or joints. This might be a dull ache or more of a stabbing pain. […] You might have a feeling of fullness or discomfort in your abdomen. […] You might lose weight even if you haven’t changed your diet. […] A type of leukaemia called T cell ALL can cause swollen lymph nodes in the centre of your chest. […] Go to the accident and emergency (AE) department at your nearest hospital if you have any of these symptoms. It can be a medical emergency.

• #2 Acute Lymphoblastic Leukemia (ALL): Symptoms, Treatment & Prognosis

  https://my.clevelandclinic.org/health/diseases/21564-acute-lymphocytic-leukemia

  Most ALL symptoms come on suddenly and affect children and adults similarly. Common initial symptoms include: Anemia. Bleeding, such as frequent nosebleeds or heavy menstrual periods. Bruising. Cough. Dizziness. Fatigue. Fever. Frequent viral infections or bacterial infections. Joint pain. Loss of appetite. Night sweats. Red, pinhead-sized spots on your skin (petechiae). Shortness of breath. Skin color that’s paler or lighter than usual. Swollen lymph nodes. Unexplained weight loss. Weakness. […] Many acute lymphoblastic leukemia symptoms mimic other less serious conditions. Having one or more of the symptoms listed above isn’t a sign that you have ALL. In general, you should talk to a healthcare provider about changes in your body that last more than two weeks. […] ALL affects your lymphocytes, a type of white blood cell that helps your body fight viruses and bacteria. Normally, your bone marrow produces immature white blood cells (lymphoblasts) that mature into healthy lymphocytes. In ALL, leukemic lymphoblasts never mature. Instead, they multiply, crowding out other blood cells and platelets before moving from your bone marrow to your bloodstream and then to other areas of your body. As a result, your platelet levels are low and you’re likely to bruise more easily, bleed more than usual or develop anemia.

• #2 Acute Lymphoblastic Leukemia (ALL): Symptoms, Diagnosis, Treatment, Prognosis, and Survival Rate

  https://www.webmd.com/cancer/lymphoma/acute-lymphoblastic-leukemia

  Some symptoms of ALL can be vague. They include: Fatigue, Fever, Loss of appetite or weight loss, Night sweats, Tiny red spots just under your skin (petechiae), Stomach pain. […] Many of the symptoms happen because your body is reacting to a lack of healthy blood cells. Leukemia cells can crowd them out in your bone marrow. […] A lack of red blood cells may cause symptoms of anemia, including: Fatigue or weakness, Dizziness or light-headedness, Feeling cold, Shortness of breath. […] Without enough healthy white blood cells, you may have: Fevers, More infections than usual. […] A lack of platelets, tiny cells that help your blood clot, may cause: Lots of bruising for no clear reason, Frequent or severe nosebleeds, bleeding gums, or other unusual bleeding, such as from minor cuts. […] Depending on where the leukemia cells are, you might also have: A full or swollen belly from cancer cells in your liver or spleen, Enlarged lymph nodes such as in your neck or groin, under your arms, or above your collarbone, Bone or joint pain, Headache, trouble with balance, vomiting, seizures, or blurred vision if the cancer has spread to your brain, Trouble breathing if it’s spread to your chest.

• #2 Acute Lymphocytic Leukemia (ALL): Causes, Symptoms, and Treatment

  https://www.everydayhealth.com/leukemia/acute-lymphocytic-leukemia/guide/

  ALL symptoms happen because of a drop in healthy blood cells, according to the American Cancer Society. Which symptoms you have depends on the type of blood cell that’s affected. […] Symptoms of low red blood cells (anemia): Dizziness, Fatigue, Pale skin, Shortness of breath. […] Symptoms of low white blood cells: Fever, Infections that don’t go away or that keep coming back. […] Symptoms of low platelets: Bleeding gums, Easy bruising, Frequent or severe nosebleeds, Heavier-than-usual menstrual periods, Small red or purple spots on the skin (petechiae). […] ALL can also cause more body-wide symptoms, such as: Appetite loss, Belly pain, Bone or joint pain, Fever, Night sweats, Swollen lymph nodes, liver, or spleen, Unexplained weight loss.

• #2 Leukemia – Symptoms and causes – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/leukemia/symptoms-causes/syc-20374373

  Leukemia symptoms vary, depending on the type of leukemia. Common leukemia signs and symptoms include: Fever or chills […] Persistent fatigue, weakness […] Frequent or severe infections […] Losing weight without trying […] Swollen lymph nodes, enlarged liver or spleen […] Easy bleeding or bruising […] Recurrent nosebleeds […] Tiny red spots in your skin (petechiae) […] Excessive sweating, especially at night […] Bone pain or tenderness. […] Leukemia symptoms are often vague and not specific. You may overlook early leukemia symptoms because they may resemble symptoms of the flu and other common illnesses. […] In acute leukemia, the abnormal blood cells are immature blood cells (blasts). They can’t carry out their normal functions, and they multiply rapidly, so the disease worsens quickly. Acute leukemia requires aggressive, timely treatment. […] When this happens, blood cell production becomes out of control. Over time, these abnormal cells can crowd out healthy blood cells in the bone marrow, leading to fewer healthy white blood cells, red blood cells and platelets, causing the signs and symptoms of leukemia.

• #2 Acute Lymphoblastic Leukaemia, Symptoms, Treatment | Nuffield Health

  https://www.nuffieldhealth.com/conditions/acute-lymphoblastic-leukaemia

  Acute lymphoblastic leukaemia (ALL) is a type of blood cancer that affects white blood cells (lymphocytes) in the bone marrow. It progesses quickly. […] Symptoms of ALL usually begin slowly before rapidly getting severe as the number of blast cells (immature white blood cells) in your blood increases. Most of the symptoms are caused by the lack of healthy blood cells in your blood supply. Symptoms of acute lymphoblastic leukaemia include: Pale skin, Easily bruised skin, Bone pain, Feeling tired and breathless, Having repeated infections over a short space of time, Unusual and frequent bleeding, such as bleeding gums or nose bleeds, Swollen lymph nodes (glands), Abdominal pain caused by a swollen liver or spleen, Unexplained weight loss, A purple skin rash (purpura). […] In some cases of ALL, the affected cells can spread from your bloodstream into your central nervous system. This can cause a series of neurological symptoms.

• #2 Acute Lymphoblastic Leukemia (ALL) Clinical Presentation: History, Physical Examination

  https://emedicine.medscape.com/article/207631-clinical

  Patients with acute lymphoblastic leukemia (ALL) present with signs and symptoms relating to direct infiltration of the marrow or other organs by leukemic cells, or with signs and symptoms relating to the decreased production of normal marrow elements. […] Fever is one of the most common signs of ALL, and patients with ALL often have fever without any other evidence of infection. […] Patients with ALL often have decreased neutrophil counts, regardless of whether their total white blood cell (WBC) count is low, normal, or elevated. […] Symptoms of anemia are common and include fatigue, dizziness, palpitations, and dyspnea upon even mild exertion. […] Other patients present with bleeding, which can be the result of thrombocytopenia due to marrow replacement. […] Additionally, approximately 10% of patients with ALL have disseminated intravascular coagulation (DIC) at the time of diagnosis.

• #2 Acute lymphoblastic leukaemia (ALL) – Leukaemia Foundation

  https://www.leukaemia.org.au/blood-cancer/types-of-blood-cancer/leukaemia/acute-lymphoblastic-leukaemia/

  Common symptoms of ALL can include: anaemia due to a lack of red cells. Anaemia can cause persistent tiredness, dizziness, paleness, or shortness of breath when physically active. frequent or repeated infections and slow healing, due to a lack of normal white cells, especially neutrophils. increased or unexplained bleeding or bruising, due to a very low platelet count. bone and/or joint pain as a result of the marrow being overcrowded with leukaemic cells. […] Other symptoms may include swollen lymph nodes (glands), chest pain and abdominal discomfort due to a swollen spleen or liver. […] Occasionally people have no symptoms and ALL is diagnosed during a routine blood test. Some of these symptoms described may also be seen in other illnesses, including viral infections, so it is important to see your doctor so that you can be examined and treated properly.

• #2 What are the symptoms of leukaemia? | Cancer Australia

  https://www.canceraustralia.gov.au/cancer-types/leukaemia/what-are-symptoms-leukaemia

  Different types of leukaemia cause different symptoms. Sometimes, a person will have no symptoms, or vague symptoms such as an ongoing cold. Symptoms of acute leukaemia often occur quickly over a few weeks, while chronic leukaemia is likely to show no symptoms, or mild symptoms which develop slowly. […] […] Acute lymphoblastic leukaemia (ALL) symptoms include tiredness and other signs of anaemia such as weakness, shortness of breath and a pale complexion – caused by a lack of red blood cells, fever and infections that don’t go away, mouth sores, sore throats, coughing, boils and frequent and painful passing of urine – caused by a lack of white blood cells, bruising and bleeding easily, nosebleeds, bleeding gums and heavy periods in women – caused by a lack of platelets, weight loss, night sweats, loss of appetite, swelling or discomfort in the abdomen – caused by a buildup of leukaemia cells in the liver and spleen, enlarged lymph nodes in the neck, underarms or groin, pain in the bones or joints, coughing and trouble breathing – caused by an enlarged thymus, a serious syndrome caused by the thymus pressing on the superior vena cava, and less common symptoms including bone or joint pain, swollen and tender gums, skin rashes, headaches, weight loss, vision problems, vomiting and chest pains.

• #2 Leukemia Symptoms: Early Stage, Late Stage, Management Tips

  https://www.healthline.com/health/leukemia/leukemia-symptoms

  Early symptoms of leukemia often include easy bleeding, frequent infections, and fatigue. […] Symptoms of acute leukemia often develop over a few weeks. Some of the early symptoms, such as fever and lethargy, may mimic those of the flu. Other possible early symptoms include: frequent infections, abnormal bleeding, such as excessive bleeding, even from small wounds, easy bruising, bleeding of your gums, heavy menstrual bleeding, frequent nosebleeds, swollen liver or swollen spleen, swollen lymph nodes, pain in your spine or your long bones, anemia symptoms, such as shortness of breath, headaches, irritability, loss of appetite, numbness and tingling in your hands and feet, weakness, severe fatigue, paleness, dizziness and lightheadedness. […] As leukemia advances, you may develop new or more severe symptoms as your blood cell counts continue to drop. Potential symptoms include: frequent infections, such as chronic respiratory infections, digestive tract infections, skin infections, severe anemia, which might cause headaches, irritability, loss of appetite, numbness and tingling in your hands and feet, weakness, severe fatigue, paleness, dizziness and lightheadedness, more severe bleeding and bruising, flat red spots on your skin (petechiae), rashes, swollen abdomen, other cancers, bone or joint pain, swollen lymph nodes.

• #2 Leukemia Symptoms | Learn The Signs Of Leukemia | LLS

  https://www.lls.org/leukemia/acute-lymphoblastic-leukemia/signs-and-symptoms

  Other general symptoms of ALL include Night sweats, Discomfort in bones or joints, Enlarged spleen, liver or lymph nodes, Pain or feeling of fullness below the ribs, Unexplained weight loss or loss of appetite, Wheezing, coughing or painful breathing. […] The signs and symptoms of acute lymphoblastic leukemia (ALL) are common to other, less serious illnesses. However, if you’re troubled by any of these symptoms, see your doctor.

• #2 Disease progression of acute lymphoblastic leukemia | Canadian Cancer Society

  https://cancer.ca/en/cancer-information/cancer-types/acute-lymphoblastic-leukemia-all/disease-progression

  Cancer cells can spread from where they start to other parts of the body. Leukemia is a cancer of the blood-forming tissue in the bone marrow, and it can develop wherever the blood travels. As a result, acute lymphoblastic leukemia (ALL) is often widespread when it is found. […] Understanding how a type of cancer usually grows and spreads helps your healthcare team plan your treatment and future care. Leukemia cells usually collect in: the peripheral blood and bone marrow, the lymph nodes, the brain and spinal cord (called the central nervous system, or CNS), the liver, the spleen, a joint or along the surface of bones, the thymus often affected with T-cell ALL, the skin, testicles, kidneys or eyes (in rare cases). […] Leukemia does not usually form solid tumours in these organs. The buildup of abnormal cells in the organs affects them so they dont work normally.

• #2 Signs and Symptoms of Acute Lymphocytic Leukemia (ALL) | American Cancer Society

  https://www.cancer.org/cancer/types/acute-lymphocytic-leukemia/detection-diagnosis-staging/signs-symptoms.html

  Leukemia cells may build up in the liver and spleen, making them larger. This might be noticed as a fullness or swelling of the belly, or feeling full after eating only a small amount. […] ALL that has spread to lymph nodes close to the surface of the body (such as on the sides of the neck, in the groin, or in underarm areas), might be noticed as lumps under the skin. […] Sometimes leukemia cells build up near the surface of the bone or inside the joint, which can lead to bone or joint pain. […] If ALL spreads to the brain and spinal cord it can cause headaches, weakness, seizures, vomiting, trouble with balance, facial muscle weakness or numbness, or blurred vision. […] The T-cell subtype of ALL often affects the thymus, which is a small organ in the middle of the chest behind the sternum (breastbone) and in front of the trachea (windpipe). An enlarged thymus can press on the trachea, which can lead to coughing or trouble breathing. […] If the thymus is enlarged, it may press on the SVC, causing the blood to back up in the veins. This is known as SVC syndrome. It can cause: Swelling in the face, neck, arms, and upper chest (sometimes with a bluish-red color), Headaches, Dizziness, Change in consciousness if it affects the brain.

• #2 Acute Lymphoblastic Leukemia – Seattle Children’s Hospital

  https://www.seattlechildrens.org/conditions/leukemia-all/

  Symptoms of ALL tend to appear over a matter of days or weeks and get worse quickly. Many of the signs and symptoms of ALL happen because cancer cells crowd out healthy blood cells or build up in the lymph nodes or other parts of the body. […] These symptoms may be caused by ALL or by another health problem. Check with a doctor if your child has: Fever, which may be a sign of infection; Easy bruising or bleeding, even from small injuries; Weakness, tiredness or feeling dizzy; Pinpoint spots of blood under the skin caused by tiny broken blood vessels; Bone or joint pain; Painless lumps in the neck, underarm, stomach, groin and around the eyes; Pain and fullness under the ribs; Loss of appetite; Shortness of breath or coughing; Headaches or problems with vision, balance or muscle control. […] In most children, leukemia grows fast and gets worse quickly without treatment. This is called acute.

• #2 Diagnosing Acute Lymphoblastic Leukemia | NYU Langone Health

  https://nyulangone.org/conditions/acute-lymphoblastic-leukemia/diagnosis

  The liver, which also filters blood, can become swollen as lymphoblasts collect there. […] A swollen spleen and liver may cause the abdomen to protrude. […] Lymphoblasts can also travel to the brain and spinal cord, causing symptoms such as headaches, seizures, or balance problems. […] Although the causes of acute lymphoblastic leukemia are not completely understood, the condition is more common in white men than in others. […] While the condition is more common in children, it can also occur in adults. […] The incidence of acute lymphoblastic leukemia after age 50 is rising. […] To diagnose the condition, a doctor asks about your medical history and symptoms. […] He or she may conduct a physical exam to check for swelling in the lymph nodes, liver, or spleen. […] Several tests can also aid in diagnosing the disease.

• #2 Symptoms of childhood acute lymphoblastic leukaemia (ALL) | Cancer Research UK

  https://www.cancerresearchuk.org/about-cancer/childrens-cancer/acute-lymphoblastic-leukaemia/symptoms

  Your child might have bony pain. Children might limp or refuse to walk as they would normally. This pain is most common in the long bones in the body, like the arms or legs. But it can also affect the back and joints. […] Your child might go off their food. They might be eating smaller amounts or not wanting to eat even their favourite foods. […] Your child might have a feeling of fullness or discomfort in their tummy (abdomen). Your childs tummy might look bigger than normal, or you might notice they suddenly jump a nappy or trouser size. […] Boys might have testicular swelling in one or both testes. This is because the leukaemia cells can collect there. This is usually painless. […] Your child might seem particularly fractious or irritable and you might be finding it difficult to get them to settle.

• #2 Acute Lymphoblastic Leukemia (ALL) | Children’s Hospital of Philadelphia

  https://www.chop.edu/conditions-diseases/acute-lymphoblastic-leukemia-all

  Acute lymphoblastic leukemia (ALL), sometimes called acute lymphocytic leukemia, is the most common form of leukemia found in children, accounting for about 30 percent of all pediatric cancers. […] The most common signs and symptoms of acute lymphoblastic leukemia in children are: […] Anemia occurs when normal red blood cells can’t be produced because the bone marrow is overcrowded by leukemia cells. […] Bleeding and/or bruising. When the bone marrow cannot produce enough platelets, bleeding can occur, especially when the platelet numbers are less than 10-20,000/mm3. […] Pain in bones and joints is usually a result of the bone marrow being crowded with leukemic blasts. […] The child with leukemia often shows non-specific symptoms of infection such as fever and fatigue. […] Leukemia cells can collect in the kidneys, liver and spleen, causing enlargement of these organs which can cause pain in the abdomen. […] Lymph nodes filter the blood. Leukemia cells often collect in the nodes, causing swelling. […] In leukemia, especially T-cell ALL, cells can clump together in the thymus a gland under the breastbone and around the throat. This mass of cells can cause difficulty breathing.

• #2 Signs and Symptoms of Acute Lymphoblastic Leukemia | MyLeukemiaTeam

  https://www.myleukemiateam.com/resources/signs-and-symptoms-of-acute-lymphoblastic-leukemia

  Certain subtypes of ALL can lead to different symptoms. T-cell ALL, which affects a type of white blood cell called T cells, can lead to problems with the thymus. An organ that sits behind the breastbone, the thymus is where T cells develop. When a person has too many cancerous T cells, the thymus can expand, causing symptoms like breathing problems or coughing. An enlarged thymus can also block a vein called the superior vena cava. Blocking this vein can lead to headaches, passing out, or swelling in the arms, neck, and face. […] ALL sometimes spreads to the central nervous system (brain and spinal cord), which can lead to additional symptoms, such as: headaches, dizziness, blurry vision, seizures.

• #2 Azthena logo with the word Azthena

  https://www.news-medical.net/health/Acute-Lymphoblastic-Leukemia-Symptoms.aspx

  Unexplained and long term fever may be one of the symptoms. Fever is usually over 38C (100.4F). […] Fever is usually accompanied by excessive sweating and night sweats. […] Swollen lymph nodes are another common symptom that may be seen. […] Liver and spleen may be enlarged and may be felt on palpating the abdomen. […] There may be loss of appetite and weight loss. […] If the cancer affects the central nervous system there may be neurological symptoms including headaches, seizures or fits, blurring of vision, stiffness of the neck, irritability and dizziness. Some patients may experience nausea and vomiting as well.

• #2 Symptoms of childhood acute lymphoblastic leukaemia (ALL) | Cancer Research UK

  https://www.cancerresearchuk.org/about-cancer/childrens-cancer/acute-lymphoblastic-leukaemia/symptoms

  Symptoms of this spread might mean your child has headaches, is having more difficulty with school work, is feeling generally weak, has had unexplained vomiting, has blurred vision, has seizures (fits). […] A type of leukaemia called T cell ALL can cause swollen lymph glands in the centre of the chest. […] Take your child to see their GP if you notice a change that isn’t normal for them or if you have any of the possible signs and symptoms of leukaemia.

• #2 Signs and symptoms of leukaemia – Leukaemia Care

  https://www.leukaemiacare.org.uk/support-and-information/information-about-blood-cancer/blood-cancer-information/signs-and-symptoms-of-leukaemia/

  The six most common symptoms experienced by all leukemia patients prior to diagnosis. These are: Fatigue, Shortness of breath, Fever or night sweats, Bruising or bleeding, Bone/joint pain, Repeated infections. […] Other less frequently experienced symptoms of leukaemia are: Swollen lymph nodes, Stomach discomfort, Nausea or vomiting, Numbness in hands or feet, Heart palpitations, Loss of concentration, Sleeping problems, Headaches, Muscle pain, Back pain, Itchy skin, Weight loss. […] The most common leukaemia in this age range is acute lymphoblastic leukaemia (ALL). The most common symptoms in this age range are: […] It is important to contact your GP, if you are displaying more than one of the above symptoms. Since the symptoms are common to other unrelated illnesses, it is unlikely that leukaemia will be the cause, however, it is for this exact reason that leukaemia can be hard to spot, as the signs and symptoms are so easily misdiagnosed. Contacting your GP earlier can be crucial for either ruling leukaemia out or getting an early diagnosis.

• #2 Symptoms of Acute Lymphoblastic Leukaemia (ALL) | Cancer Council NSW

  https://www.cancercouncil.com.au/acute-lymphoblastic-leukaemia/symptoms/

  When leukaemia causes a build-up of abnormal white blood cells, the lymph nodes and spleen can become swollen. An enlarged spleen can cause pain or discomfort in the abdomen or back. […] These include bone or joint pain, swollen and tender gums, skin rashes, headaches, weight loss, vision problems, vomiting and chest pains.

• #2 Acute lymphoblastic leukaemia | Leukaemia & Blood Cancer New Zealand

  https://www.leukaemia.org.nz/information/about-blood-cancers/leukaemia/acute-lymphoblastic-leukaemia/

  Acute lymphoblastic leukaemia (ALL) is a type of cancer of the blood and bone marrow. ALL occurs when the bone marrow makes too many immature white blood cells, called lymphoblasts or leukaemic blasts. […] This type of leukaemia can appear suddenly and progress rapidly. […] Signs and symptoms of ALL will vary from person to person. It is common for someone with ALL to feel a loss of wellbeing because of the lack of normal, healthy blood cells. […] Common signs and symptoms of infection include: Fever (high temperature), Shivering or rigors, Coughing up yellow or green phlegm, Fatigue or extreme tiredness. […] Other symptoms of ALL include recurrent drenching night sweats, unexplained weight loss, loss of appetite, bone or joint pain, enlarged lymph nodes, and swelling and pain in the abdomen.

• #2 Prevalence of symptoms in children with acute lymphoblastic leukaemia: a systematic review and meta-analysis | BMC Cancer | Full Text

  https://bmccancer.biomedcentral.com/articles/10.1186/s12885-023-11581-z

  Children with acute lymphoblastic leukaemia (ALL) experience multiple symptoms that occur in complicated patterns and negatively affect patient outcomes. […] The symptom prevalence ranged between 1.5 and 91.0% and the most frequent symptoms observed were fatigue, lack of energy, dry mouth, lack of appetite, sweating, and feeling irritable, which occurred in at least 60% of the patients. […] Symptoms remain highly prevalent in paediatric patients with ALL, which provides support for the need for symptom assessment in the clinical setting. Specific intervention is urgently needed to mitigate the symptoms in children with ALL and help them cope with the symptom burden. […] In children with ALL, 34 symptoms were identified. Symptoms remained highly prevalent in paediatric patients with ALL. The most prevalent symptoms were fatigue, lack of energy, dry mouth, lack of appetite, sweating, and feeling irritable, and these occurred in at least 60% of the children with ALL.

• #2 T-cell acute lymphoblastic leukemia: Symptoms, treatment, and more

  https://www.medicalnewstoday.com/articles/t-cell-acute-lymphoblastic-leukemia

  T-cell acute lymphoblastic leukemia (T-ALL) is a type of blood cancer that begins in the bone marrow and can spread to other organs. It is one of two forms of acute lymphoblastic leukemia (ALL), the most common childhood cancer. […] T-ALL is a fast-growing blood cancer that progresses quickly. […] The most common symptoms of T-ALL are nonspecific. Therefore, doctors may find distinguishing the condition from typical childhood diseases challenging. […] T-ALL results in fewer healthy blood cells, so it may cause generalized symptoms such as: anemia, fatigue, weakness, shortness of breath, lightheadedness, heart palpitations, frequent infections, fever, sweats, bruising, bleeding. […] An individual with T-ALL may also develop swollen lymph nodes in the middle of their chest, affecting their breathing or circulation. […] Because the condition compromises the immune system, it can lead to an increased risk of infections and other symptoms such as bleeding issues and severe fatigue. […] Many children with T-ALL have a good outlook, with 5-year survival rates of more than 85%, but this figure drops to 50% in adults.

• #2 Explore Acute Lymphoblastic Leukaemia Symptoms And Causes Symptoms and Causes at HCG Oncology

  http://www.hcgoncology.com/types-of-cancers/acute-lymphoblastic-leukaemia-symptoms-and-causes/

  In patients with acute lymphoblastic leukemia, especially T-cell ALL, the cancerous cells can cause the enlargement of the thymus, which further presses on the trachea. This can cause difficulty breathing. […] It is advisable to see an oncologist if any of the above-mentioned acute leukemia symptoms are persistent and do not go away with medications. Also, most of the acute lymphoblastic leukemia symptoms are similar to those of the flu, which can cause confusion. Thus, if the symptoms do not improve rapidly, it is better to see an oncologist. […] Acute lymphocytic leukemia is mostly seen in children, and its symptoms are usually confused with those of the flu. However, it is always advisable to never ignore these symptoms in any case and consult a doctor in case they do not get better with medicine. […] The acute leukemia symptoms are quite similar to those of the flu and are often easily ignored. Therefore, it is advisable to consult a doctor if these symptoms are persistent or do not subside with medications.

• #2 Symptoms of acute lymphoblastic leukaemia – NHS

  https://www.nhs.uk/conditions/acute-lymphoblastic-leukaemia/symptoms/

  Symptoms of acute lymphoblastic leukaemia (ALL) are not always obvious at first and can be similar to other conditions. […] They usually appear quite quickly over a few weeks. […] The main symptoms include: feeling tired or weak, bleeding or bruising easily or for no reason, looking more pale than usual, getting ill a lot or taking longer than usual to recover from illnesses, a high temperature, swollen glands (usually in the neck, armpits and groin), pain in the bones or joints, loss of appetite or losing weight without trying, shortness of breath, a swollen tummy your tummy may feel painful, uncomfortable or full. […] Less common symptoms include: a headache, being sick, blurred vision, fits (seizures), a cough, a swollen and red face, neck, arms or hands the redness may be harder to see on brown and black skin, swollen veins in the neck or chest.

• #2

  https://111.wales.nhs.uk/encyclopaedia/l/article/leukaemia,acutelymphoblastic/

  Less common symptoms include: a headache, being sick, blurred vision, fits (seizures), a cough, a swollen and red face, neck, arms or hands the redness may be harder to see on brown and black skin, swollen veins in the neck or chest. […] These symptoms are very common and can be caused by many different conditions. Having them does not definitely mean you have acute lymphoblastic leukaemia. But it’s important to get them checked. This is because if they’re caused by cancer, finding it early may mean it’s easier to treat.

• #2 Acute lymphoblastic leukaemia | NHS inform

  https://www.nhsinform.scot/illnesses-and-conditions/cancer/cancer-types-in-adults/acute-lymphoblastic-leukaemia/

  In some cases of acute lymphoblastic leukaemia, the affected cells can spread from your bloodstream into your central nervous system. This can cause a series of neurological symptoms (related to the brain and nervous system), including: headaches, seizures (fits), vomiting, blurred vision, dizziness. […] As the number of immature cells increases, the number of healthy red blood cells and platelets fall, and its this fall which causes many of the symptoms of leukaemia.

• #2 Acute Lymphocytic Leukemia – StatPearls – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK459149/

  Acute lymphocytic leukemia (ALL) is a malignancy of B or T lymphoblasts characterized by uncontrolled proliferation of abnormal, immature lymphocytes and their progenitors which ultimately leads to the replacement of bone marrow elements and other lymphoid organs resulting in a characteristic disease pattern. Patients typically present with symptoms related to anemia, thrombocytopenia, and neutropenia due to the replacement of the bone marrow with the tumor. Symptoms can include fatigue, easy or spontaneous bruising and/or bleeding, and infections. Additionally, B-symptoms, such as fever, night sweats, and unintentional weight loss, are often present but may be mild, and hepatomegaly, splenomegaly, and lymphadenopathy can be seen in up to half of adults on presentation. Central nervous system (CNS) involvement is common and can be accompanied by cranial neuropathies or symptoms, predominantly meningeal, related to increased intracranial pressure.

• #2 Acute lymphoblastic leukaemia (ALL) | Blood Cancer UK

  https://bloodcancer.org.uk/understanding-blood-cancer/leukaemia/acute-lymphoblastic-leukaemia/

  People with ALL can experience a range of symptoms, including extreme tiredness, bruising or bleeding, weight loss and frequent infections. […] ALL develops quickly, so fast diagnosis and treatment are important.

• #2 Acute Lymphoblastic Leukaemia (ALL): Signs & Treatments

  https://cfch.com.sg/acute-lymphoblastic-leukaemia-all/

  ALL is the most common type of cancer in children and accounts for 20% of blood cancers in adults. It is a type of blood cancer which leads to the overproduction of abnormal white blood cells called lymphoblasts. These lymphoblasts circulate in the bloodstream and infiltrate the bone marrow, lymph glands and other organs in the body. As a result, the normal function of the bone marrow is affected leading to poor production of red cells, normal white cells and platelets. If left untreated, it is usually fatal within 3 months of diagnosis. […] Signs & Symptoms of Acute Lymphoblastic Leukaemia (ALL) include fever, fatigue, bleeding symptoms, pale skin, weight loss, lymph node swelling, enlarged abdomen, and neurological impairment. […] Acute Lymphoblastic Leukaemia is an aggressive form of leukaemia. The overproduction of the abnormal white blood cells responsible for Acute Lymphoblastic Leukaemia can occur over several days or weeks.

• #2 Acute Lymphoblastic Leukaemia (ALL): Signs & Treatments

  https://cfch.com.sg/acute-lymphoblastic-leukaemia-all/

  Acute Lymphoblastic Leukaemia typically develops relatively quickly. The overproduction of the abnormal white blood cells responsible for Acute Lymphoblastic Leukaemia can occur over several weeks to months. […] ALL is an aggressive form of blood cancer that can progress rapidly without treatment. If left untreated, it is often rapidly fatal over a few months. This is due to the overproduction of abnormal blood cells, which suppress the production of healthy red blood cells, white blood cells, and platelets.

• #2 Acute lymphocytic leukemia Information | Mount Sinai – New York

  https://www.mountsinai.org/health-library/report/acute-lymphocytic-leukemia

  Symptoms of ALL include fatigue, pale skin, recurrent infections, bone pain, bruising, and small red spots under the skin. […] The symptoms of acute lymphocytic leukemia (ALL) may be difficult to recognize. ALL usually begins abruptly and intensely, but in some cases symptoms may develop slowly. They may be present one day, and absent the next, particularly in children. […] General symptoms of ALL include fatigue, fever, loss of appetite, unexplained weight loss, recurrent minor infections, and shortness of breath during normal activities. […] Other symptoms of ALL include paleness, bruising and bleeding, pain in bones and joints, and swollen lymph nodes. […] Acute lymphocytic leukemia can progress quickly if untreated. However, ALL is one of the most curable cancers and survival rates are now at an all-time high.

• #2 What Is Acute Lymphoblastic Leukaemia: Exploring Its Symptoms, Survival Rate, Life Expectancy, and Treatment | OnlyMyHealth

  https://www.onlymyhealth.com/acute-lymphoblastic-leukemia-causes-symptoms-types-and-treatment-12977823329

  Acute lymphoblastic leukaemia (ALL) presents with a range of symptoms that can vary in severity and duration. According to our expert, some of the key symptoms include the following. Prolonged Fever: A fever lasting more than two weeks, often without an apparent cause. Fatigue: Continued tiredness that does not improve with rest. Weight Loss: Unexplained loss of weight that may occur alongside changes in appetite. Lymph Node Swellings: Small, swollen lymph nodes in areas such as the neck, armpits, and groin. Abdominal Distention: A feeling of fullness or swelling in the abdomen. Jaundice: Yellowing of the skin and eyes, indicating potential liver involvement. Bone Pain: Particularly common in children, this can manifest as discomfort in the bones or joints. […] According to Dr Gopinathan M, ALL is termed „acute” due to the rapid onset and progression of symptoms, which can develop within days to weeks. The condition is most prevalent in children but can also occur in adults, affecting their overall health and quality of life. Early detection and treatment are vital for improving outcomes, as ALL can lead to serious complications if not addressed promptly.

• #2 Leukemia: Symptoms, Signs, Causes, Types & Treatment

  https://my.clevelandclinic.org/health/diseases/4365-leukemia

  Common signs and symptoms of leukemia include: […] Fatigue, tiring easily. […] Fever or night sweats. […] Frequent infections. […] Shortness of breath. […] Pale skin. […] Unexplained weight loss. […] Bone/joint pain or tenderness. […] Pain or full feeling under your ribs on the left side. […] Swollen lymph nodes in your neck, underarm, groin or stomach, an enlarged spleen or liver. […] Bruising and bleeding easily, including nosebleeds, bleeding gums, a rash that looks like tiny red spots in skin (petechiae) or purplish/darkened skin patches. […] If you have acute leukemia, you’ll feel sick within weeks of the leukemia cells forming. […] Acute leukemia is life-threatening and requires immediate initiation of therapy.

• #2 Acute Lymphoblastic Leukemia | Info About This Cancer | LLS

  https://www.lls.org/leukemia/acute-lymphoblastic-leukemia

  Acute Lymphoblastic Leukemia is a cancer of the bone marrow and blood. Progresses rapidly without treatment. […] ALL affects the blood cells and immune system. […] Anemia is a condition when there is a low number of red cells in the blood which can cause fatigue and shortness of breath. Neutropenia is a condition when there is a low number of white cells so that the immune system can’t effectively guard against infection due to a lack of neutrophils (a type of white cell). Thrombocytopenia is a condition when there is a low number of platelets which can cause bleeding and easy bruising with no apparent cause. Low numbers of all three blood cell counts is called pancytopenia.

• #2 Acute Lymphoblastic Leukemia Treatment – NCI

  https://www.cancer.gov/types/leukemia/patient/adult-all-treatment-pdq

  Acute lymphoblastic leukemia (ALL) is a type of cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell). […] Signs and symptoms of ALL include fatigue, fever, and easy bruising or bleeding. […] The early signs and symptoms of ALL may be like the flu or other common diseases. Check with your doctor if you have: weakness or fatigue, fever or drenching night sweats, easy bruising or bleeding, petechiae (flat, pinpoint spots under the skin, caused by bleeding), shortness of breath, weight loss or loss of appetite, pain in the bones or stomach, pain or feeling of fullness below the ribs, painless lumps in the neck, underarm, stomach, or groin, frequent infections. […] In ALL, too many stem cells become lymphoblasts, B lymphocytes, or T lymphocytes. These cells are also called leukemia cells. Leukemia cells are not able to fight infection very well. Also, as the number of leukemia cells increases in the blood and bone marrow, there is less room for healthy white blood cells, red blood cells, and platelets. This may cause infection, anemia, and easy bleeding. The cancer can also spread to the central nervous system (brain and spinal cord), lymph nodes, spleen, liver, testicles, and other organs. […] After ALL has been diagnosed, tests are done to find out if the cancer has spread to the central nervous system (brain and spinal cord) or to other parts of the body.

• #2 Childhood Acute Lymphoblastic Leukemia – NCI

  https://www.cancer.gov/types/leukemia/patient/child-all-treatment-pdq

  Symptoms of childhood ALL are caused by not having enough red blood cells and platelets and by having too many white blood cells that don’t work well. It’s important to check with your child’s doctor if your child has: […] ALL usually worsens quickly if it is not treated.

• #2 Acute Lymphoblastic Leukemia (ALL) (for Parents) | Nemours KidsHealth

  https://kidshealth.org/en/parents/all.html

  Kids with ALL may get anemia, which is when the body has too few red blood cells. This happens when bone marrow stops making the usual amount of red blood cells. […] Kids with anemia may: look pale, feel very tired or weak, get short of breath while playing. […] When they don’t have enough platelets, kids with leukemia may bruise easily, get nosebleeds, or bleed for a long time after even a minor cut. […] Other symptoms of leukemia can include: pain in the bones or joints, sometimes causing a limp, swollen lymph nodes in the neck, groin, or elsewhere, poor appetite and weight loss, fevers, belly pain. […] Because their white blood cells can’t fight infections, kids with leukemia are more likely to get viral or bacterial infections. […] Sometimes leukemia can spread, or metastasize. If it spreads to the brain, symptoms may include headaches, seizures, balance problems, or vision problems. If it spreads to the lymph nodes in the chest, symptoms can include breathing problems and chest pain. […] Acute lymphoblastic leukemia develops and gets worse quickly, so early diagnosis is important. Most kids are cured with treatment.

• #2 Acute Lymphoblastic Leukaemia (Symptoms and Treatment)

  https://patient.info/doctor/acute-lymphoblastic-leukaemia-pro

  Current treatment regimes for acute lymphoblastic leukaemia achieve complete remission rates of 80-90%, higher for standard-risk patients at over 90%, and less for high-risk patients at about 75%. […] The outcome of ALL is strictly related to the age of a patient, with cure rates from 80-90% in childhood ALL, decreasing to 10% in elderly/frail patients with ALL. Childhood ALL is one of the most curable cancers.

• #2 Symptoms of Acute Lymphoblastic Leukaemia (ALL) | Cancer Council NSW

  https://www.cancercouncil.com.au/acute-lymphoblastic-leukaemia/symptoms/

  Occasionally, a person will have no symptoms or vague symptoms such as an ongoing cold, and the leukaemia is discovered during a routine blood test. Usually, people with acute lymphoblastic leukaemia (ALL) find that some of the following symptoms appear quickly over a few weeks. […] Low levels of red blood cells (anaemia) can cause tiredness (fatigue), weakness, a pale complexion and breathlessness. […] Low platelet levels can cause bruising without a bump or fall, nosebleeds, bleeding gums, heavy periods, and small red or purple spots on the skin or mouth (called petechiae). […] A lack of normal white blood cells can cause mouth sores or ulcers, sore throats, fevers, sweats, coughing, boils, infected cuts or scratches, and frequent and painful passing of urine. A low white blood cell level can also lead to more serious infections.

• #2 Acute lymphoblastic leukemia (ALL) Information | Mount Sinai – New York

  https://www.mountsinai.org/health-library/diseases-conditions/acute-lymphoblastic-leukemia-all

  Acute lymphoblastic leukemia (ALL) is a fast-growing cancer of a type of white blood cells called lymphocytes. […] ALL makes a person more likely to bleed and develop infections. Symptoms include: Bone and joint pain, Easy bruising and bleeding (such as bleeding gums, skin bleeding, nosebleeds, abnormal periods), Feeling weak or tired, Fever, Loss of appetite and weight loss, Paleness, Pain or feeling of fullness below the ribs from an enlarged liver or spleen, Pinpoint red spots on the skin (petechiae), Swollen lymph nodes in the neck, under arms, and groin, Night sweats. […] Life-threatening symptoms can occur as normal blood counts drop.

• #2 Acute Lymphocytic Leukemia – StatPearls – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK459149/

  Patients with acute lymphocytic leukemia typically present with symptoms related to anemia, thrombocytopenia, and neutropenia due to the replacement of the bone marrow with the tumor. Symptoms can include fatigue, easy or spontaneous bruising/bleeding, and infections. B-symptoms, such as fever, night sweats, and unintentional weight loss, are often present but may be mild. Hepatomegaly, splenomegaly, and lymphadenopathy can be seen in up to half of adults on presentation. Central nervous system (CNS) involvement is common and can be accompanied by cranial neuropathies or symptoms, predominantly meningeal, related to increased intracranial pressure. […] The most common presenting symptoms of acute lymphocytic leukemia are nonspecific and may be difficult to distinguish from common, self-limited diseases of childhood. In a meta-analysis, more than half of children with childhood leukemia had at least one of the following five features on presentation: palpable liver, palpable spleen, pallor, fever, or bruising. ALL patients typically present with symptoms of night sweats, easy bruising, skin pallor, unexplained lymphadenopathy, weakness, weight loss, hepatosplenomegaly, or difficulty breathing. Some patients may present with superior vena cava syndrome. Bone pain, mental changes, and oliguria may also be present. ALL can also present with testicular enlargement, musculoskeletal pain, mediastinal mass, and incidentally found peripheral blood cell abnormalities.

• #2 Acute Lymphoblastic Leukaemia (Symptoms and Treatment)

  https://patient.info/doctor/acute-lymphoblastic-leukaemia-pro

  Patients with acute lymphoblastic leukaemia typically deteriorate rapidly. Initial presentation of acute lymphoblastic leukaemia is usually generalised fatigue and malaise but usually quickly progresses to bone marrow failure. […] Acute lymphoblastic leukaemia symptoms include fatigue, dizziness and palpitations. Severe and unusual bone and joint pain. Recurrent and severe infections (oral, throat, skin, perianal infections commonly). Fever without obvious infection (but infection should be assumed). Left upper quadrant fullness and early satiety due to splenomegaly (10-20%). Dyspnoea (due to anaemia or large mediastinal mass in those with T-cell tumours). Headache, irritability or altered mental status and neck stiffness (with central nervous system (CNS) involvement). Haemorrhagic or thrombotic complications due to thrombocytopenia or disseminated intravascular coagulopathy (DIC) – for example, menorrhagia, frequent nosebleeds, spontaneous bruising.

• #2 Childhood Acute Lymphoblastic Leukemia (ALL) | Dana-Farber Cancer Institute

  https://www.dana-farber.org/cancer-care/types/childhood-acute-lymphoblastic-leukemia

  Recurrent infections: Although there may be an unusually high number of white blood cells on your child’s blood count, these white blood cells aren’t mature and don’t fight infection. […] Abdominal pain: Stomach aches also may be a symptom of leukemia. […] Swollen lymph nodes: Your child also may have swelling in the lymph nodes under the arms, or in the groin, chest, and neck. […] Dyspnea (difficulty breathing): In some cases of ALL, leukemia cells tend to clump together and form a mass in the middle of the chest. […] ALL can cause a variety of symptoms in children based on their age and their disease type.

• #2 Symptoms of childhood acute lymphoblastic leukaemia (ALL) | Cancer Research UK

  https://www.cancerresearchuk.org/about-cancer/childrens-cancer/acute-lymphoblastic-leukaemia/symptoms

  Childhood cancer is rare. Most children with one or more of these symptoms don’t have leukaemia. But it’s important to get your GP to check any of the symptoms out. […] Many symptoms of ALL are vague and non specific. They are similar to the symptoms of many more minor childhood illness. […] Symptoms of childhood ALL can include: looking pale, feeling very tired, bruising or bleeding easily or for no reason, having a high temperature (fever), picking up infections easily and often, swollen lymph nodes, bone pain, loss of appetite, swollen tummy (abdomen), swelling of one or both testicles. […] Not every child with ALL has all of these symptoms before they are diagnosed. […] At the beginning these symptoms might come and go. Your child might be exhausted one day, but brighter the next.

• #2 Explore Acute Lymphoblastic Leukaemia Symptoms And Causes Symptoms and Causes at HCG Oncology

  http://www.hcgoncology.com/types-of-cancers/acute-lymphoblastic-leukaemia-symptoms-and-causes/

  When ALL cells accumulate in the spleen, it leads to the enlargement of the organ. This, in turn, causes pain in the abdomen region. This is one of the lymphoblastic leukemia symptoms that is easily ignored. Any pain that lasts for more than two weeks should not be ignored. […] Night sweats are common in ALL patients as the body is constantly trying to fight the disease. […] With the loss of appetite due to the accumulation of leukemia cells in the liver, spleen, and kidney, ALL patients experience unintended weight loss. […] The shortage of normal cells and the overgrowth of abnormal white blood cells can cause extreme weakness in ALL patients. […] When ALL cells spread further to other body parts, the disease causes swelling in the lymph nodes, the glands responsible for capturing bacteria and viruses.

• #3 Acute Lymphoblastic (Lymphocytic) Leukemia | Massachusetts General Hospital

  https://www.massgeneral.org/cancer-center/treatments-and-services/leukemia/about-acute-lymphoblastic-leukemia

  What are the symptoms of ALL? The abnormal leukemia cells travel throughout the body in blood vessels just like all blood cells. Sometimes they become trapped by the lymph nodes, liver or spleen, which then become enlarged. People who have ALL usually feel sick. Common ALL symptoms include: Swollen lymph nodes (in neck or armpit), usually painless […] If the brain is affected by ALL, you may have headaches, vomiting, confusion, or seizures. Leukemia symptoms may be vague and can also be caused by other illnesses. Call your treatment team if you have any of these symptoms. […] ALL is a cancer that progresses quickly without treatment. Treatment should be started right away. The goal of treatment is to remove leukemia symptoms that are present and to destroy the leukemia forming cells. This is called remission. After this point is reached, more treatment may be given to prevent a return of leukemia symptoms. This is called a relapse.

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