Materiały źródłowe

• #1 IgA Nephropathy (Berger Disease) – StatPearls – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/sites/books/NBK538214/

  Immunoglobulin A (IgA) nephropathy, or IgAN, also known as Berger disease, is one of the leading causes of glomerulonephritis and renal failure. […] Despite being a common disease, accurate prevalence data for IgAN are limited due to the necessity of a renal biopsy to establish the diagnosis. […] Although IgAN is the most common cause of glomerulonephritis, its exact prevalence remains uncertain due to many cases being asymptomatic and requiring a renal biopsy for definitive diagnosis. Not all patients undergo a biopsy to confirm the diagnosis, with some opting for conservative management, particularly if they exhibit a benign variant. Approximately 10% of renal biopsies in the United States reveal IgAN, while the prevalence is higher in East Asia (up to 40% of biopsies) and Europe (20% to 30% of biopsies).

• #2 IgA nephropathy | Cleveland Clinic Journal of Medicine

  https://www.ccjm.org/content/90/6_suppl_1/e5

  Immunoglobulin A nephropathy (IgAN) is the most common glomerulonephritis in the world, with an overall incidence of 2.5 per 100,000 per year. […] Epidemiological studies suggest that 20% to 40% of patients will develop kidney failure within 10 to 20 years of diagnosis. […] Individuals of European and East Asian ancestry are at higher risk for IgAN. […] Onset is typically during the second and third decades with a 2:1 male-to-female predominance in the United States. […] IgAN is considered to be sporadic, although genome-wide analysis studies have identified non-Mendelian polymorphisms in the major histocompatibility complex (MHC) and non-MHC risk alleles. […] The etiology of IgAN is unknown, but has been attributed to a dysregulated T-cell immune response to viral, bacterial, and food antigens activating mucosal plasma cells to produce polymeric IgA.

• #3 IgA nephropathy | Radiology Reference Article | Radiopaedia.org

  https://radiopaedia.org/articles/iga-nephropathy?embed_domain=hackmd.io%252f%2540yipuafecsl2jsu8smr5njq%252fbnjhjgjghjghjghfavicon.icofavicon.ico&lang=gb

  IgA nephropathy is considered the most common glomerulonephritis worldwide and is a leading cause of chronic kidney disease. […] It is possible that mRNA-based vaccination against COVID-19 may associate with an increased frequency of IgA nephropathy.

• #4 IgA Nephropathy (Berger Disease) – StatPearls – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/sites/books/NBK538214/

  Immunoglobulin A (IgA) nephropathy, or IgAN, also known as Berger disease, is one of the leading causes of glomerulonephritis and renal failure. […] Despite being a common disease, accurate prevalence data for IgAN are limited due to the necessity of a renal biopsy to establish the diagnosis. […] Although IgAN is the most common cause of glomerulonephritis, its exact prevalence remains uncertain due to many cases being asymptomatic and requiring a renal biopsy for definitive diagnosis. Not all patients undergo a biopsy to confirm the diagnosis, with some opting for conservative management, particularly if they exhibit a benign variant. Approximately 10% of renal biopsies in the United States reveal IgAN, while the prevalence is higher in East Asia (up to 40% of biopsies) and Europe (20% to 30% of biopsies).

• #5 IgA Nephropathy (Berger’s Disease) Treatment

  https://icloudhospital.com/specialties/iga-nephropathy-bergers-disease-treatment

  IgA nephropathy is a prevalent illness, but data on prevalence is imprecise due to the need for a kidney biopsy to confirm the diagnosis. […] In the United States, IgA nephropathy is seen in around 10% of renal biopsies. IgA nephropathy is seen in 40% of renal biopsies in Asia and 20% of renal biopsies in Europe. […] The illness is more frequent in children and young adults, with a male preponderance. […] Males are more likely than females to develop IgA nephropathy. Almost all studies reveal at least a 2:1 male preponderance, with reported ratios as high as 6:1. […] IgA nephropathy can affect people of all ages, although it is more frequent in their second and third decades. At the time of diagnosis, eighty percent of patients are between the ages of 16 and 35. […] In certain situations, the disease appears to cluster in specific families and regions of the world. It is uncommon among persons of African descent. Some experts believe that hereditary factors may play a role in the disease’s development.

• #6 Review on epidemiology, disease burden, and treatment patterns of IgA nephropathy in select APAC countries | BMC Nephrology | Full Text

  https://bmcnephrol.biomedcentral.com/articles/10.1186/s12882-024-03555-5

  Immunoglobulin type A (IgA) nephropathy is the most common primary glomerulonephritis (GN) worldwide with higher rates in East and Pacific Asia compared to North America and Europe. […] The aim of this study was to review and summarize evidence on IgA nephropathy prevalence, treatment patterns, and humanistic and economic burden in mainland China, Taiwan, South Korea, Japan, and Australia. […] IgAN prevalence is highest in Asia, intermediate in Europe and the US, and lower in African countries. […] The overall global incidence is approximately 2.5 per 100,000 people per year. […] A higher prevalence of IgAN is seen in countries where routine screening is practiced. […] The prevalence of IgA nephropathy among the general population in select countries/regions is not commonly available, despite evidence from studies and clinical guidelines.

• #7 IgA nephropathy – Wikiwand

  https://www.wikiwand.com/en/articles/IgA_nephropathy

  IgA nephropathy is the most common glomerulonephritis worldwide; the global incidence is 2.5/100,000 per year amongst adults. […] Men are affected three times as often as women. There is also marked geographic variation in the prevalence of IgA nephropathy throughout the world. It is the most common glomerular disease in the Far East and Southeast Asia, accounting for almost half of all patients with glomerular disease; however, it accounts for only about 25% of the proportion in Europeans and about 10% among North Americans, with African Americans having a very low prevalence of about 2%. […] A confounding factor in this analysis is the existing policy of screening and use of kidney biopsy as an investigative tool. School children in Japan and army recruits in Singapore undergo routine urinalysis, and any suspicious abnormality is pursued with a kidney biopsy, which might partly explain the high observed incidence of IgA nephropathy in those countries.

• #8 IgA nephropathy | Cleveland Clinic Journal of Medicine

  https://www.ccjm.org/content/90/6_suppl_1/e5

  Immunoglobulin A nephropathy (IgAN) is the most common glomerulonephritis in the world, with an overall incidence of 2.5 per 100,000 per year. […] Epidemiological studies suggest that 20% to 40% of patients will develop kidney failure within 10 to 20 years of diagnosis. […] Individuals of European and East Asian ancestry are at higher risk for IgAN. […] Onset is typically during the second and third decades with a 2:1 male-to-female predominance in the United States. […] IgAN is considered to be sporadic, although genome-wide analysis studies have identified non-Mendelian polymorphisms in the major histocompatibility complex (MHC) and non-MHC risk alleles. […] The etiology of IgAN is unknown, but has been attributed to a dysregulated T-cell immune response to viral, bacterial, and food antigens activating mucosal plasma cells to produce polymeric IgA.

• #9 A Systematic Literature Review of the Epidemiology, Health-Related Quality of Life Impact, and Economic Burden of Immunoglobulin A Nephropathy | Published in Journal of Health Economics and Outcomes Research

  https://jheor.org/article/26129-a-systematic-literature-review-of-the-epidemiology-health-related-quality-of-life-impact-and-economic-burden-of-immunoglobulin-a-nephropathy

  This systematic literature review analyzed published evidence on IgA nephropathy (IgAN), focusing on US epidemiology, health-related quality of life (HRQoL), and economic burden of illness. […] Of 123 epidemiologic studies selected for data extraction, 24 reported IgAN diagnosis rates ranging from 6.3% to 29.7% among adult and pediatric patients undergoing renal biopsy, with all reported US rates 15%. […] A meta-analysis of US studies calculated an annual incidence of 1.29/100 000 people, translating to an annual US incidence of 4236 adults and children. […] Relative to Europe, the United States had more patients diagnosed with IgAN in later chronic kidney disease stages. […] US rates of transition to end-stage renal disease (ESRD) ranged from 12.5% to 23% during 3-3.9 years of observation, rising to 53% during 19 years of observation.

• #10 New study sheds light on incidence of IgA nephropathy – Kaiser Permanente Department of Research & Evaluation

  https://www.kp-scalresearch.org/new-study-sheds-light-on-incidence-of-iga-nephropathy/

  A recent Kaiser Permanente study described the incidence of IgA nephropathy, an autoimmune kidney disease, nationally, as well as among people of different race and ethnicities. […] IgA nephropathy is a rare disease. […] The researchers assessed all adult Kaiser Permanente Southern California patients who had a kidney biopsy-proven diagnosis of IgA nephropathy between 2010 and 2021. […] Within the racially diverse population in Southern California, the study found an IgA nephropathy incidence of 1.7 cases per 100,000 person-years. […] From that the researchers matched the U.S. population on age, sex, and race to the Southern California population to come up with an estimated incidence overall in the United States of 1.4 cases of IgA nephropathy per 100,000 person years. […] The research also showed that Asian/Pacific Islander and Hispanic patients had the highest incidence rates of this disease.

• #11 IgA Nephropathy: Practice Essentials, Pathophysiology, Etiology

  https://emedicine.medscape.com/article/239927-overview

  A study from Scotland found a significant twofold increase in the diagnosis of IgA nephropathy in the patients residing in the most socioeconomically deprived areas compared with the least deprived ones. The variation was not explained by the demographics of the underlying population. […] In a study by Zhou from eastern China utilizing kidney biopsies from 2001-2017, IgA nephropathy was the most common type of primary glomerulonephritis, accounting for 50% of cases. The diagnosis rate of IgA nephropathy remained steady over that 15-year period; however, the prevalence of membranous nephropathy increased, becoming the second most common type. […] In Asia, routine urinalyses are performed for schoolchildren, and kidney biopsies are performed for patients with asymptomatic hematuria, thus raising the reported prevalence of the disease. The estimated annual incidence in Japan is 3.94.5 per 100,000 population.

• #12 IgA Nephropathy: Practice Essentials, Pathophysiology, Etiology

  https://emedicine.medscape.com/article/239927-overview

  IgA nephropathy is found in about 10% of biopsies performed for glomerular disease in the United States. Prevalence rates are lower in the United States than in Asian countries. These lower rates may be influenced by a conservative approach by nephrologists in the US, who are reluctant to perform kidney biopsies in asymptomatic patients with only mild abnormalities on urinalyses. […] Distribution of IgA nephropathy varies in different geographic regions throughout the world. IgA nephropathy is observed in up to 40% of all biopsies performed for glomerular disease in Asia, compared with 20% in Europe and 10% in North America. High prevalence rates are observed in Singapore, Japan, Australia, Hong Kong, Finland, and southern Europe, whereas low prevalence rates are the rule in the United Kingdom, Canada, and the United States.

• #13 IgA Nephropathy Treatment Market – How Therapeutics Space is Evolving?

  https://www.delveinsight.com/blog/iga-nephropathy-treatment-market

  IgA Nephropathy is a common glomerular disease across the world, but its prevalence varies greatly by geography. […] As per DelveInsights IgA Nephropathy Market Report, the total IgA Nephropathy prevalence was 377, 829 in the 7MM in 2020, with the US accounting for the maximum prevalence. Among the EU5 countries, Germany had the highest IgA Nephropathy prevalent cases in 2020. […] Another recently published report on IgA Nephropathy Epidemiology indicates that Males are more likely to be affected than females by primary IgAN. In 2020, the United States had 69,191 males and 58,169 females with IgA Nephropathy. […] Globally, IgA nephropathy is the most frequent primary glomerulonephritis that can lead to renal failure. […] IgA prevalence varies significantly among continents and ethnic groups. It is reported to be highest in industrialised Asian countries such as Japan (31%), followed by several European countries (20-30%) and the United States (10-20%).

• #14 IgA Nephropathy: Practice Essentials, Pathophysiology, Etiology

  https://emedicine.medscape.com/article/239927-overview

  IgA nephropathy is found in about 10% of biopsies performed for glomerular disease in the United States. Prevalence rates are lower in the United States than in Asian countries. These lower rates may be influenced by a conservative approach by nephrologists in the US, who are reluctant to perform kidney biopsies in asymptomatic patients with only mild abnormalities on urinalyses. […] Distribution of IgA nephropathy varies in different geographic regions throughout the world. IgA nephropathy is observed in up to 40% of all biopsies performed for glomerular disease in Asia, compared with 20% in Europe and 10% in North America. High prevalence rates are observed in Singapore, Japan, Australia, Hong Kong, Finland, and southern Europe, whereas low prevalence rates are the rule in the United Kingdom, Canada, and the United States.

• #15 Pediatric IgA Nephropathy: Practice Essentials, Pathophysiology, Etiology

  https://emedicine.medscape.com/article/981516-overview

  IgA nephropathy accounts for 5-10% of all primary glomerular diseases occurring in the United States. The prevalence of IgA nephropathy in the general population has been estimated to be about 25-50 cases per 100,000 population. Almost 5% of all biopsied patients have at least some IgA deposits in their glomeruli. The incidence of end-stage renal disease (ESRD) due to IgA nephropathy was 5.5 cases per million population per year; about 8.4 cases for males and 2.7 cases for females. […] IgA nephropathy has been diagnosed worldwide, but its prevalence in different countries varies. In Pacific countries, particularly in Japan, it accounts for approximately 50% of all primary glomerular diseases. In Europe, it is responsible for 20-30%. The explanation of this apparent variability is uncertain but may be related, in part, to differing indications for renal biopsy in different centers. High incidence rates are reported in Asia, France, Italy, Finland, and southern Europe. Genetic and environmental factors may contribute to geographic differences in prevalence. Population studies in Germany and France have calculated an incidence of 2 cases per 10,000, although autopsy studies performed in Singapore suggest that 2-4.8% of the population may have IgA deposition in their glomeruli.

• #16 IgA Nephropathy (Berger Disease): Symptoms & Treatment

  https://my.clevelandclinic.org/health/diseases/5990-iga-nephropathy

  IgA nephropathy, or Bergers disease, is a kidney disease in which IgA antibodies build up abnormally. […] IgA nephropathy is a common kidney disease that can happen to people at any age. […] In the United States, about 1 out of every 10 kidney biopsies show IgA nephropathy. In East Asian countries, IgA nephropathy appears in about 4 out of every 10 kidney biopsies. In European countries, it appears in between 2 and 3 out of every 10 kidney biopsies. […] In the U.S., males are twice as likely to have IgA nephropathy as females. […] IgA nephropathy can affect anyone at any age. But the first signs of the disease usually occur in a persons late teens to late 30s. […] About 1 in 4 adults with IgA nephropathy eventually develop kidney failure. About 1 in every 10 to 20 children with IgA nephropathy develop kidney failure.

• #17 IgA Nephropathy (Berger Disease) – StatPearls – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/sites/books/NBK538214/

  Immunoglobulin A (IgA) nephropathy, or IgAN, also known as Berger disease, is one of the leading causes of glomerulonephritis and renal failure. […] Despite being a common disease, accurate prevalence data for IgAN are limited due to the necessity of a renal biopsy to establish the diagnosis. […] Although IgAN is the most common cause of glomerulonephritis, its exact prevalence remains uncertain due to many cases being asymptomatic and requiring a renal biopsy for definitive diagnosis. Not all patients undergo a biopsy to confirm the diagnosis, with some opting for conservative management, particularly if they exhibit a benign variant. Approximately 10% of renal biopsies in the United States reveal IgAN, while the prevalence is higher in East Asia (up to 40% of biopsies) and Europe (20% to 30% of biopsies).

• #18 IgA Nephropathy: Practice Essentials, Pathophysiology, Etiology

  https://emedicine.medscape.com/article/239927-overview

  IgA nephropathy is found in about 10% of biopsies performed for glomerular disease in the United States. Prevalence rates are lower in the United States than in Asian countries. These lower rates may be influenced by a conservative approach by nephrologists in the US, who are reluctant to perform kidney biopsies in asymptomatic patients with only mild abnormalities on urinalyses. […] Distribution of IgA nephropathy varies in different geographic regions throughout the world. IgA nephropathy is observed in up to 40% of all biopsies performed for glomerular disease in Asia, compared with 20% in Europe and 10% in North America. High prevalence rates are observed in Singapore, Japan, Australia, Hong Kong, Finland, and southern Europe, whereas low prevalence rates are the rule in the United Kingdom, Canada, and the United States.

• #19 Pediatric IgA Nephropathy: Practice Essentials, Pathophysiology, Etiology

  https://emedicine.medscape.com/article/981516-overview

  The distribution of IgA nephropathy varies in different geographic regions throughout the world. It is the most common form of primary glomerular disease in Asia, accounting for as much as 30-40% of all biopsy findings, for 20% of biopsies in Europe, and for 10% of all biopsies performed for glomerular disease in North America. The reason for this wide variance in incidence is partly attributable to indications for renal biopsy in Asia compared to those in North America. In the United States, incidence of IgA nephropathy is increased in children who are Asian or White; incidence is lowest in children who are Black. […] Incidence is higher in males than in females. Male-to-female ratios of 2:1 and 6:1 have been reported. […] IgA nephropathy occurs in persons of all ages but is still most common in the second and third decades of life and is much more common in males than females. IgA nephropathy is uncommon in children younger than 10 years. In fact, 80% of patients are between the ages of 16-35 years at the time of renal biopsy.

• #20 IgA Nephropathy: Practice Essentials, Pathophysiology, Etiology

  https://emedicine.medscape.com/article/239927-overview

  IgA nephropathy is found in about 10% of biopsies performed for glomerular disease in the United States. Prevalence rates are lower in the United States than in Asian countries. These lower rates may be influenced by a conservative approach by nephrologists in the US, who are reluctant to perform kidney biopsies in asymptomatic patients with only mild abnormalities on urinalyses. […] Distribution of IgA nephropathy varies in different geographic regions throughout the world. IgA nephropathy is observed in up to 40% of all biopsies performed for glomerular disease in Asia, compared with 20% in Europe and 10% in North America. High prevalence rates are observed in Singapore, Japan, Australia, Hong Kong, Finland, and southern Europe, whereas low prevalence rates are the rule in the United Kingdom, Canada, and the United States.

• #21 IgA nephropathy – Wikiwand

  https://www.wikiwand.com/en/articles/IgA_nephropathy

  IgA nephropathy is the most common glomerulonephritis worldwide; the global incidence is 2.5/100,000 per year amongst adults. […] Men are affected three times as often as women. There is also marked geographic variation in the prevalence of IgA nephropathy throughout the world. It is the most common glomerular disease in the Far East and Southeast Asia, accounting for almost half of all patients with glomerular disease; however, it accounts for only about 25% of the proportion in Europeans and about 10% among North Americans, with African Americans having a very low prevalence of about 2%. […] A confounding factor in this analysis is the existing policy of screening and use of kidney biopsy as an investigative tool. School children in Japan and army recruits in Singapore undergo routine urinalysis, and any suspicious abnormality is pursued with a kidney biopsy, which might partly explain the high observed incidence of IgA nephropathy in those countries.

• #22 IgA_nephropathy

  https://www.bionity.com/en/encyclopedia/IgA_nephropathy.html

  IgA nephropathy is the most common glomerulonephritis throughout the world. […] Men are affected three times as often as women. There is also a striking geographic variation in the prevalence of IgA nephropathy throughout the world. It is the most common glomerular disease in the Far East and Southeast Asia, comprising almost half of all the patients with glomerular disease. However, it comprises only about 25% of the proportion in European and about 10% among North Americans, with African Americans having a very low prevalence of about 2%. A confounding factor in this analysis is the existing policy of screening and use of kidney biopsy as an investigative tool. School children in Japan undergo routine urinalysis (as do Army recruits in Singapore) and any suspicious abnormality is pursued with a kidney biopsy, which might partly explain the high incidence of IgA nephropathy in those countries.

• #23 IgA Nephropathy (Berger Disease) – StatPearls – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/sites/books/NBK538214/

  Routine screening of hematuria in East Asian schoolchildren is believed to contribute to the early detection of microscopic hematuria, thereby contributing to the increased diagnosis of IgAN. […] In the United States, IgAN appears to affect White populations more than Black individuals disproportionately. […] The disease commonly manifests in children and young adults, with a peak incidence in the second and third decades of life. A male predominance ratio of about 2.5:1 is present in the United States and Europe, whereas the ratio is closer to 1:1 in East Asia.

• #24 IgA Nephropathy (Berger Disease) | Treatment & Management | Point of Care

  https://www.statpearls.com/point-of-care/23357

  In addition, evidence also suggests that ESRD is more common among East Asian patients diagnosed with IgAN than non-Asian patients. […] In the United States, IgAN appears to affect White populations more than Black individuals disproportionately. […] The disease commonly manifests in children and young adults, with a peak incidence in the second and third decades of life. […] A male predominance ratio of about 2.5:1 is present in the United States and Europe, whereas the ratio is closer to 1:1 in East Asia.

• #25 IgA nephropathy – Wikiwand

  https://www.wikiwand.com/en/articles/IgA_nephropathy

  IgA nephropathy is the most common glomerulonephritis worldwide; the global incidence is 2.5/100,000 per year amongst adults. […] Men are affected three times as often as women. There is also marked geographic variation in the prevalence of IgA nephropathy throughout the world. It is the most common glomerular disease in the Far East and Southeast Asia, accounting for almost half of all patients with glomerular disease; however, it accounts for only about 25% of the proportion in Europeans and about 10% among North Americans, with African Americans having a very low prevalence of about 2%. […] A confounding factor in this analysis is the existing policy of screening and use of kidney biopsy as an investigative tool. School children in Japan and army recruits in Singapore undergo routine urinalysis, and any suspicious abnormality is pursued with a kidney biopsy, which might partly explain the high observed incidence of IgA nephropathy in those countries.

• #26 IgA_nephropathy

  https://www.bionity.com/en/encyclopedia/IgA_nephropathy.html

  IgA nephropathy is the most common glomerulonephritis throughout the world. […] Men are affected three times as often as women. There is also a striking geographic variation in the prevalence of IgA nephropathy throughout the world. It is the most common glomerular disease in the Far East and Southeast Asia, comprising almost half of all the patients with glomerular disease. However, it comprises only about 25% of the proportion in European and about 10% among North Americans, with African Americans having a very low prevalence of about 2%. A confounding factor in this analysis is the existing policy of screening and use of kidney biopsy as an investigative tool. School children in Japan undergo routine urinalysis (as do Army recruits in Singapore) and any suspicious abnormality is pursued with a kidney biopsy, which might partly explain the high incidence of IgA nephropathy in those countries.

• #27 IgA Nephropathy Treatment Market – How Therapeutics Space is Evolving?

  https://www.delveinsight.com/blog/iga-nephropathy-treatment-market

  Different healthcare screening strategies, biopsy techniques, and genetic and environmental factors could contribute to this variation. […] In East Asian countries like Japan and South Korea, annual urine analysis in schools and workplaces is legally mandated. […] However, there is no national kidney disease screening program in most Western countries, such as the United States, the United Kingdom, and others.

• #28 IgA_nephropathy

  https://www.bionity.com/en/encyclopedia/IgA_nephropathy.html

  IgA nephropathy is the most common glomerulonephritis throughout the world. […] Men are affected three times as often as women. There is also a striking geographic variation in the prevalence of IgA nephropathy throughout the world. It is the most common glomerular disease in the Far East and Southeast Asia, comprising almost half of all the patients with glomerular disease. However, it comprises only about 25% of the proportion in European and about 10% among North Americans, with African Americans having a very low prevalence of about 2%. A confounding factor in this analysis is the existing policy of screening and use of kidney biopsy as an investigative tool. School children in Japan undergo routine urinalysis (as do Army recruits in Singapore) and any suspicious abnormality is pursued with a kidney biopsy, which might partly explain the high incidence of IgA nephropathy in those countries.

• #29 IgA Nephropathy (Berger Disease) – StatPearls – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/sites/books/NBK538214/

  Routine screening of hematuria in East Asian schoolchildren is believed to contribute to the early detection of microscopic hematuria, thereby contributing to the increased diagnosis of IgAN. […] In the United States, IgAN appears to affect White populations more than Black individuals disproportionately. […] The disease commonly manifests in children and young adults, with a peak incidence in the second and third decades of life. A male predominance ratio of about 2.5:1 is present in the United States and Europe, whereas the ratio is closer to 1:1 in East Asia.

• #30 IgA Nephropathy (Berger Disease) | Treatment & Management | Point of Care

  https://www.statpearls.com/point-of-care/23357

  Immunoglobulin A (IgA) nephropathy, or IgAN, is one of the leading causes of glomerulonephritis and renal failure. […] Prevalence varies based on ethnicity, race, geography, and genetics, with Asian patients being more commonly and severely affected. […] Although IgAN is the most common cause of glomerulonephritis, its exact prevalence remains uncertain due to many cases being asymptomatic and requiring a renal biopsy for definitive diagnosis. […] Approximately 10% of renal biopsies in the United States reveal IgAN, while the prevalence is higher in East Asia (up to 40% of biopsies) and Europe (20% to 30% of biopsies). […] Routine screening of hematuria in East Asian schoolchildren is believed to contribute to the early detection of microscopic hematuria, thereby contributing to the increased diagnosis of IgAN.

• #31 IgA Nephropathy Treatment Market – How Therapeutics Space is Evolving?

  https://www.delveinsight.com/blog/iga-nephropathy-treatment-market

  Different healthcare screening strategies, biopsy techniques, and genetic and environmental factors could contribute to this variation. […] In East Asian countries like Japan and South Korea, annual urine analysis in schools and workplaces is legally mandated. […] However, there is no national kidney disease screening program in most Western countries, such as the United States, the United Kingdom, and others.

• #32 IgA Nephropathy: Practice Essentials, Pathophysiology, Etiology

  https://emedicine.medscape.com/article/239927-overview

  IgA nephropathy is found in about 10% of biopsies performed for glomerular disease in the United States. Prevalence rates are lower in the United States than in Asian countries. These lower rates may be influenced by a conservative approach by nephrologists in the US, who are reluctant to perform kidney biopsies in asymptomatic patients with only mild abnormalities on urinalyses. […] Distribution of IgA nephropathy varies in different geographic regions throughout the world. IgA nephropathy is observed in up to 40% of all biopsies performed for glomerular disease in Asia, compared with 20% in Europe and 10% in North America. High prevalence rates are observed in Singapore, Japan, Australia, Hong Kong, Finland, and southern Europe, whereas low prevalence rates are the rule in the United Kingdom, Canada, and the United States.

• #33 Berger’s Disease in Urgent Care: A Case Report – Journal of Urgent Care Medicine

  https://www.jucm.com/bergers-disease-in-urgent-care-a-case-report/

  IgA nephropathysometimes known as Bergers diseasewas first described in 1968. It is the most common primary glomerular disease in the world. It is more common in children and young adults, and slightly more common in males. There appears to be a higher prevalence in Asian countries than in the United States or Europe, but this is likely due to a higher rate of screening and of renal biopsies in those countries when compared to North America and Europe. […] In fact, because of the higher threshold to biopsy by most North American nephrologists, true epidemiologic data is lacking. […] There have been some studies suggesting a genetic component, however, most data supports the theory that IgAN is a sporadic condition.

• #34 IgA Nephropathy (Berger Disease) – StatPearls – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/sites/books/NBK538214/

  Routine screening of hematuria in East Asian schoolchildren is believed to contribute to the early detection of microscopic hematuria, thereby contributing to the increased diagnosis of IgAN. […] In the United States, IgAN appears to affect White populations more than Black individuals disproportionately. […] The disease commonly manifests in children and young adults, with a peak incidence in the second and third decades of life. A male predominance ratio of about 2.5:1 is present in the United States and Europe, whereas the ratio is closer to 1:1 in East Asia.

• #35 IgA Nephropathy (Berger Disease) | Treatment & Management | Point of Care

  https://www.statpearls.com/point-of-care/23357

  In addition, evidence also suggests that ESRD is more common among East Asian patients diagnosed with IgAN than non-Asian patients. […] In the United States, IgAN appears to affect White populations more than Black individuals disproportionately. […] The disease commonly manifests in children and young adults, with a peak incidence in the second and third decades of life. […] A male predominance ratio of about 2.5:1 is present in the United States and Europe, whereas the ratio is closer to 1:1 in East Asia.

• #36 IgA nephropathy – Knowledge @ AMBOSS

  https://www.amboss.com/us/knowledge/iga-nephropathy/

  IgA nephropathy is the most common primary glomerulonephritis in adults. […] Peak incidence: second to third decades of life. […] Sex: (2:1). […] Ethnicity: more common in the Asian population (worldwide). […] IgAN is the most common cause of kidney failure in individuals of age. […] Even with treatment, 20-40% of patients with IgAN develop ESRD within 20 years.

• #37 Pediatric IgA Nephropathy: Practice Essentials, Pathophysiology, Etiology

  https://emedicine.medscape.com/article/981516-overview

  The distribution of IgA nephropathy varies in different geographic regions throughout the world. It is the most common form of primary glomerular disease in Asia, accounting for as much as 30-40% of all biopsy findings, for 20% of biopsies in Europe, and for 10% of all biopsies performed for glomerular disease in North America. The reason for this wide variance in incidence is partly attributable to indications for renal biopsy in Asia compared to those in North America. In the United States, incidence of IgA nephropathy is increased in children who are Asian or White; incidence is lowest in children who are Black. […] Incidence is higher in males than in females. Male-to-female ratios of 2:1 and 6:1 have been reported. […] IgA nephropathy occurs in persons of all ages but is still most common in the second and third decades of life and is much more common in males than females. IgA nephropathy is uncommon in children younger than 10 years. In fact, 80% of patients are between the ages of 16-35 years at the time of renal biopsy.

• #38 Orphanet: Immunoglobulin A nephropathy

  https://www.orpha.net/en/disease/detail/34145

  In Europe, the annual incidence of IgA nephropathy (IgAN) is approximately 1/131,578, with a point prevalence of 1/3952. Higher prevalences are observed in Asia and lower prevalences in Africa. The male to female ratio is about 2:1 in Europeans. IgAN is rare in children younger than 10-12 years. […] The prognosis over 5-6 years can be estimated using the International IgAN Prediction Tool. Major prognostic parameters include the degree of proteinuria, GFR impairment at baseline, hypertension, nicotine consumption and obesity. However, in particular in younger adults with IgAN even low levels of proteinuria.

• #39 Pediatric IgA Nephropathy: Practice Essentials, Pathophysiology, Etiology

  https://emedicine.medscape.com/article/981516-overview

  The distribution of IgA nephropathy varies in different geographic regions throughout the world. It is the most common form of primary glomerular disease in Asia, accounting for as much as 30-40% of all biopsy findings, for 20% of biopsies in Europe, and for 10% of all biopsies performed for glomerular disease in North America. The reason for this wide variance in incidence is partly attributable to indications for renal biopsy in Asia compared to those in North America. In the United States, incidence of IgA nephropathy is increased in children who are Asian or White; incidence is lowest in children who are Black. […] Incidence is higher in males than in females. Male-to-female ratios of 2:1 and 6:1 have been reported. […] IgA nephropathy occurs in persons of all ages but is still most common in the second and third decades of life and is much more common in males than females. IgA nephropathy is uncommon in children younger than 10 years. In fact, 80% of patients are between the ages of 16-35 years at the time of renal biopsy.

• #40 IgA Nephropathy: Practice Essentials, Pathophysiology, Etiology

  https://emedicine.medscape.com/article/239927-overview

  IgA nephropathy is more common in Asians and Whites and is rare in Blacks, both in the United States and in Africa. The condition is frequently observed in Native Americans of the Zuni and Navajo tribes. […] IgA nephropathy is more common in males than in females. Virtually all studies show a male predominance of at least 2:1, with reported ratios of up to 6:1. The higher male predilection is observed in White patients in northern Europe and the United States. […] IgA nephropathy can affect all ages but is most common in the second and third decades of life. Eighty percent of patients are aged 16-35 years at the time of diagnosis. The condition is uncommon in children younger than 10 years. […] In a study by Huang et al in Chinese subjects with IgA nephropathy, which compared cases that progressed to end-stage renal disease (ESRD) with controls that did not, the proportion of patients who were males, smokers, alcohol drinkers, and physically inactive was significantly higher in cases than in controls. Alcohol use proved to be an independent risk factor for progression to ESRD, while regular exercise was associated with decreased risk; males who did not exercise seemed especially likely to progress to ESRD. These authors concluded that physical exercise should be encouraged in IgA nephropathy patients, especially in males, for a better renal outcome, and cessation of alcohol use might help prevent disease progression.

• #41 IgA Nephropathy (Berger Disease) | Treatment & Management | Point of Care

  https://www.statpearls.com/point-of-care/23357

  In addition, evidence also suggests that ESRD is more common among East Asian patients diagnosed with IgAN than non-Asian patients. […] In the United States, IgAN appears to affect White populations more than Black individuals disproportionately. […] The disease commonly manifests in children and young adults, with a peak incidence in the second and third decades of life. […] A male predominance ratio of about 2.5:1 is present in the United States and Europe, whereas the ratio is closer to 1:1 in East Asia.

• #42 Pediatric IgA Nephropathy: Practice Essentials, Pathophysiology, Etiology

  https://emedicine.medscape.com/article/981516-overview

  The distribution of IgA nephropathy varies in different geographic regions throughout the world. It is the most common form of primary glomerular disease in Asia, accounting for as much as 30-40% of all biopsy findings, for 20% of biopsies in Europe, and for 10% of all biopsies performed for glomerular disease in North America. The reason for this wide variance in incidence is partly attributable to indications for renal biopsy in Asia compared to those in North America. In the United States, incidence of IgA nephropathy is increased in children who are Asian or White; incidence is lowest in children who are Black. […] Incidence is higher in males than in females. Male-to-female ratios of 2:1 and 6:1 have been reported. […] IgA nephropathy occurs in persons of all ages but is still most common in the second and third decades of life and is much more common in males than females. IgA nephropathy is uncommon in children younger than 10 years. In fact, 80% of patients are between the ages of 16-35 years at the time of renal biopsy.

• #43 IgA Nephropathy (Berger’s Disease) Treatment

  https://icloudhospital.com/specialties/iga-nephropathy-bergers-disease-treatment

  IgA nephropathy is a prevalent illness, but data on prevalence is imprecise due to the need for a kidney biopsy to confirm the diagnosis. […] In the United States, IgA nephropathy is seen in around 10% of renal biopsies. IgA nephropathy is seen in 40% of renal biopsies in Asia and 20% of renal biopsies in Europe. […] The illness is more frequent in children and young adults, with a male preponderance. […] Males are more likely than females to develop IgA nephropathy. Almost all studies reveal at least a 2:1 male preponderance, with reported ratios as high as 6:1. […] IgA nephropathy can affect people of all ages, although it is more frequent in their second and third decades. At the time of diagnosis, eighty percent of patients are between the ages of 16 and 35. […] In certain situations, the disease appears to cluster in specific families and regions of the world. It is uncommon among persons of African descent. Some experts believe that hereditary factors may play a role in the disease’s development.

• #44 IgA Nephropathy (Berger Disease) | Treatment & Management | Point of Care

  https://www.statpearls.com/point-of-care/23357

  In addition, evidence also suggests that ESRD is more common among East Asian patients diagnosed with IgAN than non-Asian patients. […] In the United States, IgAN appears to affect White populations more than Black individuals disproportionately. […] The disease commonly manifests in children and young adults, with a peak incidence in the second and third decades of life. […] A male predominance ratio of about 2.5:1 is present in the United States and Europe, whereas the ratio is closer to 1:1 in East Asia.

• #45 Pathology Outlines – IgA nephropathy

  https://www.pathologyoutlines.com/topic/kidneyiga.html

  Most common primary glomerulonephritis worldwide (UptoDate: Clinical Presentation and Diagnosis of IgA Nephropathy [Accessed 6 April 2020]) […] More common in Southern Europe, Asia and Native Americans; less common in individuals of African lineage […] First to seventh decade of life; peak 20 – 30 years […] M:F = 2:1 in Europe / U.S. and 1:1 in Asia.

• #46 IgA Nephropathy: Practice Essentials, Pathophysiology, Etiology

  https://emedicine.medscape.com/article/239927-overview

  The prevalence of IgA nephropathy is highest in geographic areas with large numbers of endemic helminthic species that infest humans, and most of the IgA nephropathy susceptibility loci identified by genome-wide association studies include genes involved in the maintenance of the intestinal epithelial barrier and response to mucosal pathogens, which would confer protection against helminthic infestation. Thus, the increased risk of IgA nephropathy in these populations may be an untoward consequence of a protective adaptation to helminthic infections. It would also explain the association of mucosal infections as a frequent trigger for IgA nephropathy. […] This disorder is thought to follow a benign course in most cases. However, many patients are at risk for slow progression to end-stage renal disease, which develops in approximately 15% of patients by 10 years and 20% by 20 years, though these percentages depend on how the disease is defined.

• #47 IgA Nephropathy: Practice Essentials, Pathophysiology, Etiology

  https://emedicine.medscape.com/article/239927-overview

  The prevalence of IgA nephropathy is highest in geographic areas with large numbers of endemic helminthic species that infest humans, and most of the IgA nephropathy susceptibility loci identified by genome-wide association studies include genes involved in the maintenance of the intestinal epithelial barrier and response to mucosal pathogens, which would confer protection against helminthic infestation. Thus, the increased risk of IgA nephropathy in these populations may be an untoward consequence of a protective adaptation to helminthic infections. It would also explain the association of mucosal infections as a frequent trigger for IgA nephropathy. […] This disorder is thought to follow a benign course in most cases. However, many patients are at risk for slow progression to end-stage renal disease, which develops in approximately 15% of patients by 10 years and 20% by 20 years, though these percentages depend on how the disease is defined.

• #48 IgA nephropathy | Cleveland Clinic Journal of Medicine

  https://www.ccjm.org/content/90/6_suppl_1/e5

  Immunoglobulin A nephropathy (IgAN) is the most common glomerulonephritis in the world, with an overall incidence of 2.5 per 100,000 per year. […] Epidemiological studies suggest that 20% to 40% of patients will develop kidney failure within 10 to 20 years of diagnosis. […] Individuals of European and East Asian ancestry are at higher risk for IgAN. […] Onset is typically during the second and third decades with a 2:1 male-to-female predominance in the United States. […] IgAN is considered to be sporadic, although genome-wide analysis studies have identified non-Mendelian polymorphisms in the major histocompatibility complex (MHC) and non-MHC risk alleles. […] The etiology of IgAN is unknown, but has been attributed to a dysregulated T-cell immune response to viral, bacterial, and food antigens activating mucosal plasma cells to produce polymeric IgA.

• #49 IgA Nephropathy: 4 Complications

  https://www.healthline.com/health/kidney-disease/complications-iga-nephropathy

  IgAN, also known as Berger disease, is a type of kidney disease. Its one of the leading causes of kidney failure and glomerulonephritis inflammation of the kidneys filtration structures called the glomeruli. […] In IgAN, approximately 1 in 5 people will develop kidney failure within 10 years after diagnosis. […] A 2023 long-term cohort study in the United Kingdom on IgAN outcomes found that of more than 2,200 people living with IgAN, 50% reached kidney failure or end of life by the 10-year follow-up mark. […] Hypertension, CKD, nephrotic syndrome, and kidney failure are potential complications of IgAN.

• #50 IgA Vasculitis and IgA Nephropathy: Same Disease?

  https://www.mdpi.com/2077-0383/10/11/2310

  The risk of progression to end-stage renal disease (ESRD) is reported from 4% after 4.6 years in Europe to 11% after 15 years of follow-up in Japan and 14% in China. […] In adults, IgAN is the cause of ESRD of 3.6% of newly dialyzed patients. […] Whatever the studies, there is definitely an age difference between patients with IgAN and those with IgAV. […] They highlight a bimodal distribution for IgAV with two peaks between 1 to 19 years and 60 to 69 years, whereas for IgAN, the peak is rather between 30 to 39 years.

• #51 IgA Nephropathy: What Is New in Treatment Options?

  https://www.mdpi.com/2673-8236/4/4/19

  IgA nephropathy (IgAN), first described in 1968, is one of the most common forms of glomerulonephritis and can progress to end-stage kidney disease (ESKD) in 25 to 30 percent of patients within 20 to 25 years from the onset. […] The prognosis may be difficult to predict, but important risk factors for disease progression of kidney disease have been recognized: usually proteinuria above 0.75–1 g/day with or without hematuria, hypertension, high-risk histologic features (such as crescent formation, immune deposits in the capillary loops, mesangial deposits, glomerulosclerosis, tubular atrophy, interstitial fibrosis, and vascular disease), and a reduced Glomerular Filtration Rate (GFR). […] At the current time, there are no disease-specific therapies available for IgAN, because no largescale RCTs have demonstrated a reduction in mortality or in major adverse kidney or cardiovascular events with any therapy.

• #52 IgA Nephropathy: What Is New in Treatment Options?

  https://www.mdpi.com/2673-8236/4/4/19

  The current standard of care is addressed to reduce proteinuria, avoid GFR reduction, and closely control blood pressure. […] The importance of histology and microhematuria in addressing therapy in IgAN. […] The Oxford classification of IgA proposed a pathologic scoring system that suggests histologic variables (MEST-C) to independently predict kidney outcomes, using a reproducible biopsy reporting system able to predict renal disease progression, helping clinicians to identify patients who might benefit from immunosuppression. […] The need for reliable prognostic tools has become pressing: patients with IgAN are defined to be at high risk of progression to ESKD when proteinuria is more than 0.75–1 g/day and when there is associated CKD. […] The combination of high-risk aspects, including proteinuria >1 g/day, severe hematuria (defined as ≥21 RBCs/hpf), and histological findings of E1 and C ≥ 1, should lead clinicians to suspect that the risk of renal worsening is high.

• #53 Orphanet: Immunoglobulin A nephropathy

  https://www.orpha.net/en/disease/detail/34145

  In Europe, the annual incidence of IgA nephropathy (IgAN) is approximately 1/131,578, with a point prevalence of 1/3952. Higher prevalences are observed in Asia and lower prevalences in Africa. The male to female ratio is about 2:1 in Europeans. IgAN is rare in children younger than 10-12 years. […] The prognosis over 5-6 years can be estimated using the International IgAN Prediction Tool. Major prognostic parameters include the degree of proteinuria, GFR impairment at baseline, hypertension, nicotine consumption and obesity. However, in particular in younger adults with IgAN even low levels of proteinuria.

• #54 Immunoglobulin A Nephropathy – Genitourinary Disorders – MSD Manual Professional Edition

  https://www.msdmanuals.com/professional/genitourinary-disorders/glomerular-disorders/immunoglobulin-a-nephropathy

  IgA nephropathy is the most common form of glomerulonephritis worldwide and is more common in Asian and certain European countries than in African and South American countries (1). […] It occurs at all ages, with a peak onset in the 20s and 30s, and generally affects males more than females, though prevalence varies throughout the world (2, 3). […] A substantial number of healthy people have IgA kidney deposits, but not all people with IgA deposits develop clinical disease. […] Progression to kidney failure is variable, occurring in 5 to 60% of patients after 10 years (1). […] Risk factors for progressive deterioration in kidney function include the following: Proteinuria 1 g/day, Elevated serum creatinine level, Uncontrolled hypertension, Persistent microscopic hematuria, Extensive fibrotic changes in the glomerulus or interstitium, Crescents on biopsy.

• #55 IgA Nephropathy: What Is New in Treatment Options?

  https://www.mdpi.com/2673-8236/4/4/19

  IgA nephropathy (IgAN), first described in 1968, is one of the most common forms of glomerulonephritis and can progress to end-stage kidney disease (ESKD) in 25 to 30 percent of patients within 20 to 25 years from the onset. […] The prognosis may be difficult to predict, but important risk factors for disease progression of kidney disease have been recognized: usually proteinuria above 0.75–1 g/day with or without hematuria, hypertension, high-risk histologic features (such as crescent formation, immune deposits in the capillary loops, mesangial deposits, glomerulosclerosis, tubular atrophy, interstitial fibrosis, and vascular disease), and a reduced Glomerular Filtration Rate (GFR). […] At the current time, there are no disease-specific therapies available for IgAN, because no largescale RCTs have demonstrated a reduction in mortality or in major adverse kidney or cardiovascular events with any therapy.

• #56 Immunoglobulin A Nephropathy – Genitourinary Disorders – MSD Manual Professional Edition

  https://www.msdmanuals.com/professional/genitourinary-disorders/glomerular-disorders/immunoglobulin-a-nephropathy

  IgA nephropathy is the most common form of glomerulonephritis worldwide and is more common in Asian and certain European countries than in African and South American countries (1). […] It occurs at all ages, with a peak onset in the 20s and 30s, and generally affects males more than females, though prevalence varies throughout the world (2, 3). […] A substantial number of healthy people have IgA kidney deposits, but not all people with IgA deposits develop clinical disease. […] Progression to kidney failure is variable, occurring in 5 to 60% of patients after 10 years (1). […] Risk factors for progressive deterioration in kidney function include the following: Proteinuria 1 g/day, Elevated serum creatinine level, Uncontrolled hypertension, Persistent microscopic hematuria, Extensive fibrotic changes in the glomerulus or interstitium, Crescents on biopsy.

• #57

  https://journals.lww.com/jasn/fulltext/2024/01000/treatment_of_iga_nephropathy__a_rapidly_evolving.12.aspx

  In addition, remission of proteinuria is associated with improved kidney outcomes, supporting the notion that every effort should be made to reduce proteinuria to 1 g/d. […] Persistent microscopic hematuria thus has emerged as a biomarker of disease activity in IgA nephropathy, independent of proteinuria, but even more so in the presence of proteinuria. […] Each of the components of the revised Oxford classification of IgA nephropathy M=mesangial hypercellularity, E=endocapillary hypercellularity, S=segmental glomerulosclerosis, T=tubular atrophy/interstitial fibrosis, C=crescents (MEST-C) score has been shown to individually predict renal outcome, independent of clinical data. […] Mesangial proliferation, endocapillary proliferation, and crescents are active inflammatory lesions, with the potential to identify high-risk patients who would benefit from immunosuppressive treatment.

• #58 Immunoglobulin A Nephropathy – Genitourinary Disorders – MSD Manual Professional Edition

  https://www.msdmanuals.com/professional/genitourinary-disorders/glomerular-disorders/immunoglobulin-a-nephropathy

  IgA nephropathy is the most common form of glomerulonephritis worldwide and is more common in Asian and certain European countries than in African and South American countries (1). […] It occurs at all ages, with a peak onset in the 20s and 30s, and generally affects males more than females, though prevalence varies throughout the world (2, 3). […] A substantial number of healthy people have IgA kidney deposits, but not all people with IgA deposits develop clinical disease. […] Progression to kidney failure is variable, occurring in 5 to 60% of patients after 10 years (1). […] Risk factors for progressive deterioration in kidney function include the following: Proteinuria 1 g/day, Elevated serum creatinine level, Uncontrolled hypertension, Persistent microscopic hematuria, Extensive fibrotic changes in the glomerulus or interstitium, Crescents on biopsy.

• #59 IgA Nephropathy: What Is New in Treatment Options?

  https://www.mdpi.com/2673-8236/4/4/19

  The current standard of care is addressed to reduce proteinuria, avoid GFR reduction, and closely control blood pressure. […] The importance of histology and microhematuria in addressing therapy in IgAN. […] The Oxford classification of IgA proposed a pathologic scoring system that suggests histologic variables (MEST-C) to independently predict kidney outcomes, using a reproducible biopsy reporting system able to predict renal disease progression, helping clinicians to identify patients who might benefit from immunosuppression. […] The need for reliable prognostic tools has become pressing: patients with IgAN are defined to be at high risk of progression to ESKD when proteinuria is more than 0.75–1 g/day and when there is associated CKD. […] The combination of high-risk aspects, including proteinuria >1 g/day, severe hematuria (defined as ≥21 RBCs/hpf), and histological findings of E1 and C ≥ 1, should lead clinicians to suspect that the risk of renal worsening is high.

• #60 IgA Nephropathy: Practice Essentials, Pathophysiology, Etiology

  https://emedicine.medscape.com/article/239927-overview

  IgA nephropathy is more common in Asians and Whites and is rare in Blacks, both in the United States and in Africa. The condition is frequently observed in Native Americans of the Zuni and Navajo tribes. […] IgA nephropathy is more common in males than in females. Virtually all studies show a male predominance of at least 2:1, with reported ratios of up to 6:1. The higher male predilection is observed in White patients in northern Europe and the United States. […] IgA nephropathy can affect all ages but is most common in the second and third decades of life. Eighty percent of patients are aged 16-35 years at the time of diagnosis. The condition is uncommon in children younger than 10 years. […] In a study by Huang et al in Chinese subjects with IgA nephropathy, which compared cases that progressed to end-stage renal disease (ESRD) with controls that did not, the proportion of patients who were males, smokers, alcohol drinkers, and physically inactive was significantly higher in cases than in controls. Alcohol use proved to be an independent risk factor for progression to ESRD, while regular exercise was associated with decreased risk; males who did not exercise seemed especially likely to progress to ESRD. These authors concluded that physical exercise should be encouraged in IgA nephropathy patients, especially in males, for a better renal outcome, and cessation of alcohol use might help prevent disease progression.

• #61 IgA Nephropathy: Practice Essentials, Pathophysiology, Etiology

  https://emedicine.medscape.com/article/239927-overview

  IgA nephropathy is more common in Asians and Whites and is rare in Blacks, both in the United States and in Africa. The condition is frequently observed in Native Americans of the Zuni and Navajo tribes. […] IgA nephropathy is more common in males than in females. Virtually all studies show a male predominance of at least 2:1, with reported ratios of up to 6:1. The higher male predilection is observed in White patients in northern Europe and the United States. […] IgA nephropathy can affect all ages but is most common in the second and third decades of life. Eighty percent of patients are aged 16-35 years at the time of diagnosis. The condition is uncommon in children younger than 10 years. […] In a study by Huang et al in Chinese subjects with IgA nephropathy, which compared cases that progressed to end-stage renal disease (ESRD) with controls that did not, the proportion of patients who were males, smokers, alcohol drinkers, and physically inactive was significantly higher in cases than in controls. Alcohol use proved to be an independent risk factor for progression to ESRD, while regular exercise was associated with decreased risk; males who did not exercise seemed especially likely to progress to ESRD. These authors concluded that physical exercise should be encouraged in IgA nephropathy patients, especially in males, for a better renal outcome, and cessation of alcohol use might help prevent disease progression.

• #62 IgA nephropathy | Cleveland Clinic Journal of Medicine

  https://www.ccjm.org/content/90/6_suppl_1/e5

  Immunoglobulin A nephropathy (IgAN) is the most common glomerulonephritis in the world, with an overall incidence of 2.5 per 100,000 per year. […] Epidemiological studies suggest that 20% to 40% of patients will develop kidney failure within 10 to 20 years of diagnosis. […] Individuals of European and East Asian ancestry are at higher risk for IgAN. […] Onset is typically during the second and third decades with a 2:1 male-to-female predominance in the United States. […] IgAN is considered to be sporadic, although genome-wide analysis studies have identified non-Mendelian polymorphisms in the major histocompatibility complex (MHC) and non-MHC risk alleles. […] The etiology of IgAN is unknown, but has been attributed to a dysregulated T-cell immune response to viral, bacterial, and food antigens activating mucosal plasma cells to produce polymeric IgA.

• #63 Is IgA Nephropathy Genetic?

  https://www.healthline.com/health/kidney-disease/is-iga-nephropathy-genetic

  IgAN is rare, with only about 25 new diagnoses per every 1 million people worldwide, though rates vary considerably by region. […] It’s much more common in Far East Asia than in Europe or North America. […] Studies estimate the heritability of IgAN to be between 40% and 50%. […] Due to its genetic component, race and ethnicity may play a role in IgAN risk. […] Studies suggest that people of Asian descent are more likely to develop IgAN than people of European or African descent.

• #64

  https://link.springer.com/article/10.1007/BF00849253

  The epidemiology of Berger’s disease is poorly defined. We know that the disease occurs worldwide and that there may be an increased occurrence in certain ethnic groups. […] The association of certain HLA antigens with the occurrence of Berger’s disease has been demonstrated by several groups. […] The multiple occurrence of Berger’s disease or of Berger’s disease and Henoch-Schnlein purpura in the same family has been reported. […] The preliminary results of a French collaborative study show 43 such families. […] However, these facts do not demonstrate a familial clustering since the multiple occurrence of cases in a family may occur by chance. […] Further systematic studies on a large number of HLA-typed affected sibling pairs are needed before concluding a linkage between HLA and the disease.

• #65 IgA Nephropathy: Practice Essentials, Pathophysiology, Etiology

  https://emedicine.medscape.com/article/239927-overview

  The prevalence of IgA nephropathy is highest in geographic areas with large numbers of endemic helminthic species that infest humans, and most of the IgA nephropathy susceptibility loci identified by genome-wide association studies include genes involved in the maintenance of the intestinal epithelial barrier and response to mucosal pathogens, which would confer protection against helminthic infestation. Thus, the increased risk of IgA nephropathy in these populations may be an untoward consequence of a protective adaptation to helminthic infections. It would also explain the association of mucosal infections as a frequent trigger for IgA nephropathy. […] This disorder is thought to follow a benign course in most cases. However, many patients are at risk for slow progression to end-stage renal disease, which develops in approximately 15% of patients by 10 years and 20% by 20 years, though these percentages depend on how the disease is defined.

• #66 IgA Nephropathy (Berger’s Disease): ERKNet voor Patiënten

  https://www.erknet.org/patients/nl/your-kidney-disease/iga-nephropathy/disease-information

  The disease affects people of all ages, although it is most often diagnosed in people under 30 years of age, particularly in older children and adolescents, more often in male and white individuals in patients of European descent, but with no gender predilection in patients of Asian descent. […] The disease is more often diagnosed among individuals with coeliac disease (gluten intolerance) or the coexistence of other immune-mediated diseases (inflammatory bowel disease, asthma, psoriasis). […] IgAN can be secondary to other diseases, e.g. systemic diseases, including: Ankylosing Spondylitis, Rheumatoid arthritis, Reiters Syndrome, Coeliac Disease, Inflammatory Bowel Disease, Alcoholic Liver Disease, Sarcoidosis, Psoriasis, Hepatitis B or C. […] IgAN may also be a part of a systemic disease, called IgA vasculitis, where patients exhibit a skin rash, IgAN, joint pain (arthritis) and/or belly pain (arising from an inflamed bowel).

• #67 IgA Nephropathy (Berger’s Disease): ERKNet voor Patiënten

  https://www.erknet.org/patients/nl/your-kidney-disease/iga-nephropathy/disease-information

  The disease affects people of all ages, although it is most often diagnosed in people under 30 years of age, particularly in older children and adolescents, more often in male and white individuals in patients of European descent, but with no gender predilection in patients of Asian descent. […] The disease is more often diagnosed among individuals with coeliac disease (gluten intolerance) or the coexistence of other immune-mediated diseases (inflammatory bowel disease, asthma, psoriasis). […] IgAN can be secondary to other diseases, e.g. systemic diseases, including: Ankylosing Spondylitis, Rheumatoid arthritis, Reiters Syndrome, Coeliac Disease, Inflammatory Bowel Disease, Alcoholic Liver Disease, Sarcoidosis, Psoriasis, Hepatitis B or C. […] IgAN may also be a part of a systemic disease, called IgA vasculitis, where patients exhibit a skin rash, IgAN, joint pain (arthritis) and/or belly pain (arising from an inflamed bowel).

• #68 IgA Nephropathy (Berger’s Disease): ERKNet for Patients

  https://www.erknet.org/patients/your-kidney-disease/iga-nephropathy/disease-information

  IgA Nephropathy (IgAN), in past sometimes known as Bergers Disease, is an inflammatory disease of the kidney, the most common primary glomerulonephritis worldwide as well a leading cause of End-Stage Kidney Disease (ESKD). […] IgAN is one of the most common idiopathic glomerulonephritis in the world. It is estimated that IgAN nephropathy accounts for as much as 15-40% of all primary glomerulopathies. […] The disease affects people of all ages, although it is most often diagnosed in people under 30 years of age, particularly in older children and adolescents, more often in male and white individuals in patients of European descent, but with no gender predilection in patients of Asian descent. […] IgAN can be secondary to other diseases, e.g. systemic diseases, including: Ankylosing Spondylitis(AS) Rheumatoid arthritis Reiters Syndrome Coeliac Disease Inflammatory Bowel Disease Alcoholic Liver Disease Sarcoidosis Psoriasis Hepatitis B or C.

• #69 IgA Nephropathy (Berger’s Disease): ERKNet voor Patiënten

  https://www.erknet.org/patients/nl/your-kidney-disease/iga-nephropathy/disease-information

  The disease affects people of all ages, although it is most often diagnosed in people under 30 years of age, particularly in older children and adolescents, more often in male and white individuals in patients of European descent, but with no gender predilection in patients of Asian descent. […] The disease is more often diagnosed among individuals with coeliac disease (gluten intolerance) or the coexistence of other immune-mediated diseases (inflammatory bowel disease, asthma, psoriasis). […] IgAN can be secondary to other diseases, e.g. systemic diseases, including: Ankylosing Spondylitis, Rheumatoid arthritis, Reiters Syndrome, Coeliac Disease, Inflammatory Bowel Disease, Alcoholic Liver Disease, Sarcoidosis, Psoriasis, Hepatitis B or C. […] IgAN may also be a part of a systemic disease, called IgA vasculitis, where patients exhibit a skin rash, IgAN, joint pain (arthritis) and/or belly pain (arising from an inflamed bowel).

• #70 IgA Nephropathy (Berger’s Disease): ERKNet for Patients

  https://www.erknet.org/patients/your-kidney-disease/iga-nephropathy/disease-information

  IgA Nephropathy (IgAN), in past sometimes known as Bergers Disease, is an inflammatory disease of the kidney, the most common primary glomerulonephritis worldwide as well a leading cause of End-Stage Kidney Disease (ESKD). […] IgAN is one of the most common idiopathic glomerulonephritis in the world. It is estimated that IgAN nephropathy accounts for as much as 15-40% of all primary glomerulopathies. […] The disease affects people of all ages, although it is most often diagnosed in people under 30 years of age, particularly in older children and adolescents, more often in male and white individuals in patients of European descent, but with no gender predilection in patients of Asian descent. […] IgAN can be secondary to other diseases, e.g. systemic diseases, including: Ankylosing Spondylitis(AS) Rheumatoid arthritis Reiters Syndrome Coeliac Disease Inflammatory Bowel Disease Alcoholic Liver Disease Sarcoidosis Psoriasis Hepatitis B or C.

• #71 IgA Nephropathy (Berger’s Disease): ERKNet voor Patiënten

  https://www.erknet.org/patients/nl/your-kidney-disease/iga-nephropathy/disease-information

  The disease affects people of all ages, although it is most often diagnosed in people under 30 years of age, particularly in older children and adolescents, more often in male and white individuals in patients of European descent, but with no gender predilection in patients of Asian descent. […] The disease is more often diagnosed among individuals with coeliac disease (gluten intolerance) or the coexistence of other immune-mediated diseases (inflammatory bowel disease, asthma, psoriasis). […] IgAN can be secondary to other diseases, e.g. systemic diseases, including: Ankylosing Spondylitis, Rheumatoid arthritis, Reiters Syndrome, Coeliac Disease, Inflammatory Bowel Disease, Alcoholic Liver Disease, Sarcoidosis, Psoriasis, Hepatitis B or C. […] IgAN may also be a part of a systemic disease, called IgA vasculitis, where patients exhibit a skin rash, IgAN, joint pain (arthritis) and/or belly pain (arising from an inflamed bowel).

• #72 IgA Nephropathy (Berger’s Disease): ERKNet for Patients

  https://www.erknet.org/patients/your-kidney-disease/iga-nephropathy/disease-information

  IgA Nephropathy (IgAN), in past sometimes known as Bergers Disease, is an inflammatory disease of the kidney, the most common primary glomerulonephritis worldwide as well a leading cause of End-Stage Kidney Disease (ESKD). […] IgAN is one of the most common idiopathic glomerulonephritis in the world. It is estimated that IgAN nephropathy accounts for as much as 15-40% of all primary glomerulopathies. […] The disease affects people of all ages, although it is most often diagnosed in people under 30 years of age, particularly in older children and adolescents, more often in male and white individuals in patients of European descent, but with no gender predilection in patients of Asian descent. […] IgAN can be secondary to other diseases, e.g. systemic diseases, including: Ankylosing Spondylitis(AS) Rheumatoid arthritis Reiters Syndrome Coeliac Disease Inflammatory Bowel Disease Alcoholic Liver Disease Sarcoidosis Psoriasis Hepatitis B or C.

• #73 IgA Nephropathy (Berger’s Disease): ERKNet voor Patiënten

  https://www.erknet.org/patients/nl/your-kidney-disease/iga-nephropathy/disease-information

  The disease affects people of all ages, although it is most often diagnosed in people under 30 years of age, particularly in older children and adolescents, more often in male and white individuals in patients of European descent, but with no gender predilection in patients of Asian descent. […] The disease is more often diagnosed among individuals with coeliac disease (gluten intolerance) or the coexistence of other immune-mediated diseases (inflammatory bowel disease, asthma, psoriasis). […] IgAN can be secondary to other diseases, e.g. systemic diseases, including: Ankylosing Spondylitis, Rheumatoid arthritis, Reiters Syndrome, Coeliac Disease, Inflammatory Bowel Disease, Alcoholic Liver Disease, Sarcoidosis, Psoriasis, Hepatitis B or C. […] IgAN may also be a part of a systemic disease, called IgA vasculitis, where patients exhibit a skin rash, IgAN, joint pain (arthritis) and/or belly pain (arising from an inflamed bowel).

• #74 IgA Nephropathy (Berger’s Disease): ERKNet for Patients

  https://www.erknet.org/patients/your-kidney-disease/iga-nephropathy/disease-information

  IgA Nephropathy (IgAN), in past sometimes known as Bergers Disease, is an inflammatory disease of the kidney, the most common primary glomerulonephritis worldwide as well a leading cause of End-Stage Kidney Disease (ESKD). […] IgAN is one of the most common idiopathic glomerulonephritis in the world. It is estimated that IgAN nephropathy accounts for as much as 15-40% of all primary glomerulopathies. […] The disease affects people of all ages, although it is most often diagnosed in people under 30 years of age, particularly in older children and adolescents, more often in male and white individuals in patients of European descent, but with no gender predilection in patients of Asian descent. […] IgAN can be secondary to other diseases, e.g. systemic diseases, including: Ankylosing Spondylitis(AS) Rheumatoid arthritis Reiters Syndrome Coeliac Disease Inflammatory Bowel Disease Alcoholic Liver Disease Sarcoidosis Psoriasis Hepatitis B or C.

• #75 IgA Nephropathy (Berger’s Disease): ERKNet voor Patiënten

  https://www.erknet.org/patients/nl/your-kidney-disease/iga-nephropathy/disease-information

  The disease affects people of all ages, although it is most often diagnosed in people under 30 years of age, particularly in older children and adolescents, more often in male and white individuals in patients of European descent, but with no gender predilection in patients of Asian descent. […] The disease is more often diagnosed among individuals with coeliac disease (gluten intolerance) or the coexistence of other immune-mediated diseases (inflammatory bowel disease, asthma, psoriasis). […] IgAN can be secondary to other diseases, e.g. systemic diseases, including: Ankylosing Spondylitis, Rheumatoid arthritis, Reiters Syndrome, Coeliac Disease, Inflammatory Bowel Disease, Alcoholic Liver Disease, Sarcoidosis, Psoriasis, Hepatitis B or C. […] IgAN may also be a part of a systemic disease, called IgA vasculitis, where patients exhibit a skin rash, IgAN, joint pain (arthritis) and/or belly pain (arising from an inflamed bowel).

• #76 IgA Nephropathy (Berger’s Disease): ERKNet for Patients

  https://www.erknet.org/patients/your-kidney-disease/iga-nephropathy/disease-information

  IgA Nephropathy (IgAN), in past sometimes known as Bergers Disease, is an inflammatory disease of the kidney, the most common primary glomerulonephritis worldwide as well a leading cause of End-Stage Kidney Disease (ESKD). […] IgAN is one of the most common idiopathic glomerulonephritis in the world. It is estimated that IgAN nephropathy accounts for as much as 15-40% of all primary glomerulopathies. […] The disease affects people of all ages, although it is most often diagnosed in people under 30 years of age, particularly in older children and adolescents, more often in male and white individuals in patients of European descent, but with no gender predilection in patients of Asian descent. […] IgAN can be secondary to other diseases, e.g. systemic diseases, including: Ankylosing Spondylitis(AS) Rheumatoid arthritis Reiters Syndrome Coeliac Disease Inflammatory Bowel Disease Alcoholic Liver Disease Sarcoidosis Psoriasis Hepatitis B or C.

• #77 IgA Nephropathy (Berger’s Disease): ERKNet voor Patiënten

  https://www.erknet.org/patients/nl/your-kidney-disease/iga-nephropathy/disease-information

  The disease affects people of all ages, although it is most often diagnosed in people under 30 years of age, particularly in older children and adolescents, more often in male and white individuals in patients of European descent, but with no gender predilection in patients of Asian descent. […] The disease is more often diagnosed among individuals with coeliac disease (gluten intolerance) or the coexistence of other immune-mediated diseases (inflammatory bowel disease, asthma, psoriasis). […] IgAN can be secondary to other diseases, e.g. systemic diseases, including: Ankylosing Spondylitis, Rheumatoid arthritis, Reiters Syndrome, Coeliac Disease, Inflammatory Bowel Disease, Alcoholic Liver Disease, Sarcoidosis, Psoriasis, Hepatitis B or C. […] IgAN may also be a part of a systemic disease, called IgA vasculitis, where patients exhibit a skin rash, IgAN, joint pain (arthritis) and/or belly pain (arising from an inflamed bowel).

• #78 IgA Nephropathy (Berger’s Disease): ERKNet for Patients

  https://www.erknet.org/patients/your-kidney-disease/iga-nephropathy/disease-information

  IgA Nephropathy (IgAN), in past sometimes known as Bergers Disease, is an inflammatory disease of the kidney, the most common primary glomerulonephritis worldwide as well a leading cause of End-Stage Kidney Disease (ESKD). […] IgAN is one of the most common idiopathic glomerulonephritis in the world. It is estimated that IgAN nephropathy accounts for as much as 15-40% of all primary glomerulopathies. […] The disease affects people of all ages, although it is most often diagnosed in people under 30 years of age, particularly in older children and adolescents, more often in male and white individuals in patients of European descent, but with no gender predilection in patients of Asian descent. […] IgAN can be secondary to other diseases, e.g. systemic diseases, including: Ankylosing Spondylitis(AS) Rheumatoid arthritis Reiters Syndrome Coeliac Disease Inflammatory Bowel Disease Alcoholic Liver Disease Sarcoidosis Psoriasis Hepatitis B or C.

• #79 IgA Nephropathy (Berger’s Disease): ERKNet voor Patiënten

  https://www.erknet.org/patients/nl/your-kidney-disease/iga-nephropathy/disease-information

  The disease affects people of all ages, although it is most often diagnosed in people under 30 years of age, particularly in older children and adolescents, more often in male and white individuals in patients of European descent, but with no gender predilection in patients of Asian descent. […] The disease is more often diagnosed among individuals with coeliac disease (gluten intolerance) or the coexistence of other immune-mediated diseases (inflammatory bowel disease, asthma, psoriasis). […] IgAN can be secondary to other diseases, e.g. systemic diseases, including: Ankylosing Spondylitis, Rheumatoid arthritis, Reiters Syndrome, Coeliac Disease, Inflammatory Bowel Disease, Alcoholic Liver Disease, Sarcoidosis, Psoriasis, Hepatitis B or C. […] IgAN may also be a part of a systemic disease, called IgA vasculitis, where patients exhibit a skin rash, IgAN, joint pain (arthritis) and/or belly pain (arising from an inflamed bowel).

• #80 IgA Nephropathy (Berger’s Disease): ERKNet for Patients

  https://www.erknet.org/patients/your-kidney-disease/iga-nephropathy/disease-information

  IgA Nephropathy (IgAN), in past sometimes known as Bergers Disease, is an inflammatory disease of the kidney, the most common primary glomerulonephritis worldwide as well a leading cause of End-Stage Kidney Disease (ESKD). […] IgAN is one of the most common idiopathic glomerulonephritis in the world. It is estimated that IgAN nephropathy accounts for as much as 15-40% of all primary glomerulopathies. […] The disease affects people of all ages, although it is most often diagnosed in people under 30 years of age, particularly in older children and adolescents, more often in male and white individuals in patients of European descent, but with no gender predilection in patients of Asian descent. […] IgAN can be secondary to other diseases, e.g. systemic diseases, including: Ankylosing Spondylitis(AS) Rheumatoid arthritis Reiters Syndrome Coeliac Disease Inflammatory Bowel Disease Alcoholic Liver Disease Sarcoidosis Psoriasis Hepatitis B or C.

• #81 IgA Nephropathy (Berger’s Disease): ERKNet voor Patiënten

  https://www.erknet.org/patients/nl/your-kidney-disease/iga-nephropathy/disease-information

  The disease affects people of all ages, although it is most often diagnosed in people under 30 years of age, particularly in older children and adolescents, more often in male and white individuals in patients of European descent, but with no gender predilection in patients of Asian descent. […] The disease is more often diagnosed among individuals with coeliac disease (gluten intolerance) or the coexistence of other immune-mediated diseases (inflammatory bowel disease, asthma, psoriasis). […] IgAN can be secondary to other diseases, e.g. systemic diseases, including: Ankylosing Spondylitis, Rheumatoid arthritis, Reiters Syndrome, Coeliac Disease, Inflammatory Bowel Disease, Alcoholic Liver Disease, Sarcoidosis, Psoriasis, Hepatitis B or C. […] IgAN may also be a part of a systemic disease, called IgA vasculitis, where patients exhibit a skin rash, IgAN, joint pain (arthritis) and/or belly pain (arising from an inflamed bowel).

• #82 IgA Nephropathy (Berger’s Disease): ERKNet for Patients

  https://www.erknet.org/patients/your-kidney-disease/iga-nephropathy/disease-information

  IgA Nephropathy (IgAN), in past sometimes known as Bergers Disease, is an inflammatory disease of the kidney, the most common primary glomerulonephritis worldwide as well a leading cause of End-Stage Kidney Disease (ESKD). […] IgAN is one of the most common idiopathic glomerulonephritis in the world. It is estimated that IgAN nephropathy accounts for as much as 15-40% of all primary glomerulopathies. […] The disease affects people of all ages, although it is most often diagnosed in people under 30 years of age, particularly in older children and adolescents, more often in male and white individuals in patients of European descent, but with no gender predilection in patients of Asian descent. […] IgAN can be secondary to other diseases, e.g. systemic diseases, including: Ankylosing Spondylitis(AS) Rheumatoid arthritis Reiters Syndrome Coeliac Disease Inflammatory Bowel Disease Alcoholic Liver Disease Sarcoidosis Psoriasis Hepatitis B or C.

• #83 Causes and Risk Factors of IgA Nephropathy

  https://www.health.com/iga-nephropathy-causes-8702882

  IgA nephropathy is one of the most common causes of chronic kidney disease, alongside high blood pressure and diabetes. Roughly 1 in 10 kidney biopsies in the United States indicate IgA nephropathy. […] The prevalence of IgA nephropathy varies by global geographic region. For example, evidence shows this condition is present in 40% of kidney biopsies done in Asia, compared to 20% in Europe and 10% in North America. […] IgA nephropathy has also been associated with other conditions that affect the immune system, such as Sjgren’s syndrome, spondyloarthritis, systemic lupus erythematosus (lupus), and Behet disease.

• #84 IgA Nephropathy (Berger’s Disease): ERKNet voor Patiënten

  https://www.erknet.org/patients/nl/your-kidney-disease/iga-nephropathy/disease-information

  The disease affects people of all ages, although it is most often diagnosed in people under 30 years of age, particularly in older children and adolescents, more often in male and white individuals in patients of European descent, but with no gender predilection in patients of Asian descent. […] The disease is more often diagnosed among individuals with coeliac disease (gluten intolerance) or the coexistence of other immune-mediated diseases (inflammatory bowel disease, asthma, psoriasis). […] IgAN can be secondary to other diseases, e.g. systemic diseases, including: Ankylosing Spondylitis, Rheumatoid arthritis, Reiters Syndrome, Coeliac Disease, Inflammatory Bowel Disease, Alcoholic Liver Disease, Sarcoidosis, Psoriasis, Hepatitis B or C. […] IgAN may also be a part of a systemic disease, called IgA vasculitis, where patients exhibit a skin rash, IgAN, joint pain (arthritis) and/or belly pain (arising from an inflamed bowel).

• #85 IgA Nephropathy (Berger’s Disease): ERKNet for Patients

  https://www.erknet.org/patients/your-kidney-disease/iga-nephropathy/disease-information

  IgAN may also be a part of a systemic disease, called IgA vasculitis (in the past called Schnlein-Henoch vasculitis), where patients exhibit a skin rash, IgAN, joint pain (arthritis) and/or belly pain (arising from an inflamed bowel). […] Tous les patients atteints d’IgAN doivent subir des examens réguliers, en particulier des analyses d’urine, des analyses de sang et une surveillance de la tension artérielle.

• #86 IgA Nephropathy: Practice Essentials, Pathophysiology, Etiology

  https://emedicine.medscape.com/article/239927-overview

  A study from Scotland found a significant twofold increase in the diagnosis of IgA nephropathy in the patients residing in the most socioeconomically deprived areas compared with the least deprived ones. The variation was not explained by the demographics of the underlying population. […] In a study by Zhou from eastern China utilizing kidney biopsies from 2001-2017, IgA nephropathy was the most common type of primary glomerulonephritis, accounting for 50% of cases. The diagnosis rate of IgA nephropathy remained steady over that 15-year period; however, the prevalence of membranous nephropathy increased, becoming the second most common type. […] In Asia, routine urinalyses are performed for schoolchildren, and kidney biopsies are performed for patients with asymptomatic hematuria, thus raising the reported prevalence of the disease. The estimated annual incidence in Japan is 3.94.5 per 100,000 population.

• #87 IgA Nephropathy (Berger Disease): Symptoms & Treatment

  https://my.clevelandclinic.org/health/diseases/5990-iga-nephropathy

  A 2017 study of adults with IgA nephropathy in the southeastern U.S. found that life expectancy is reduced by a little over 10 years. The average age of death was just under 66 years, while the expected age of death if you dont have kidney disease was just under 76 years. […] A 2019 study in Sweden found that life expectancy is reduced by about 6 years.

• #88 IgA Nephropathy (Berger Disease): Symptoms & Treatment

  https://my.clevelandclinic.org/health/diseases/5990-iga-nephropathy

  A 2017 study of adults with IgA nephropathy in the southeastern U.S. found that life expectancy is reduced by a little over 10 years. The average age of death was just under 66 years, while the expected age of death if you dont have kidney disease was just under 76 years. […] A 2019 study in Sweden found that life expectancy is reduced by about 6 years.

• #89 IgA Nephropathy (Berger’s Disease): ERKNet voor Patiënten

  https://www.erknet.org/patients/nl/your-kidney-disease/iga-nephropathy/disease-information

  IgA Nephropathy (IgAN), in past sometimes known as Bergers Disease, is an inflammatory disease of the kidney, the most common primary glomerulonephritis worldwide as well a leading cause of End-Stage Kidney Disease (ESKD). […] IgAN can occur at any age, both in adults and young children. […] The disease is often detected accidentally. Proteinuria (protein in the urine) and/or haematuria (blood in the urine) are found during routine check-ups. […] Tous les patients atteints d’IgAN doivent subir des examens réguliers, en particulier des analyses d’urine, des analyses de sang et une surveillance de la tension artérielle. […] IgAN is one of the most common idiopathic glomerulonephritis in the world. It is estimated that IgAN nephropathy accounts for as much as 15-40% of all primary glomerulopathies.

• #90 IgA Nephropathy (Berger’s Disease): ERKNet for Patients

  https://www.erknet.org/patients/your-kidney-disease/iga-nephropathy/disease-information

  IgAN may also be a part of a systemic disease, called IgA vasculitis (in the past called Schnlein-Henoch vasculitis), where patients exhibit a skin rash, IgAN, joint pain (arthritis) and/or belly pain (arising from an inflamed bowel). […] Tous les patients atteints d’IgAN doivent subir des examens réguliers, en particulier des analyses d’urine, des analyses de sang et une surveillance de la tension artérielle.

• #91 IgA nephropathy | Cleveland Clinic Journal of Medicine

  https://www.ccjm.org/content/90/6_suppl_1/e5

  The International IgA Nephropathy Network and the Renal Pathology Society developed the Oxford MEST-C pathologic scoring system, which should accompany all kidney biopsy reports to help predict kidney outcomes in patients with IgAN. […] Kidney biopsies that reveal chronic lesions (higher S and T scores) are probably less likely to be amendable to immunosuppressive therapy. […] The International IgA Nephropathy Prediction Tool may be used to impute clinical data and MEST-C scores to predict the risk of a 50% decline in estimated glomerular filtration rate (eGFR). […] All patients should be treated with lifestyle modification and maximal RAS blockade, especially if proteinuria is present. […] Prognostication tools are available to balance the risk and benefits of non-immunosuppressive and immunosuppressive therapies.

• #92

  https://journals.lww.com/jasn/fulltext/2024/01000/treatment_of_iga_nephropathy__a_rapidly_evolving.12.aspx

  The ability of histologic markers to predict a benefit of early glucocorticoids on top of RAASi versus RAASi alone is the subject of two ongoing prospective studies in European IgA nephropathy patients. […] The International IgA Nephropathy Prediction Tool calculates the 5-year risk of a 50% decrease in eGFR or development of ESKD, based on a number of clinical (eGFR, BP, proteinuria, age, race/ethnicity, use of RAASi) and histologic (MEST score) variables at the time of kidney biopsy. […] Optimization of supportive care consists of lifestyle modifications with smoking cessation, dietary sodium and protein restriction, weight control and exercise, statins in patients with hypercholesterolemia, BP control, and proteinuria reduction with maximally tolerated RAASi. […] The initial approach to all patients with IgA nephropathy therefore consists of optimization of supportive care for at least 3 months, with the understanding that the 3-month period starts when target BP has been achieved.

• #93 IgA nephropathy | Cleveland Clinic Journal of Medicine

  https://www.ccjm.org/content/90/6_suppl_1/e5

  The International IgA Nephropathy Network and the Renal Pathology Society developed the Oxford MEST-C pathologic scoring system, which should accompany all kidney biopsy reports to help predict kidney outcomes in patients with IgAN. […] Kidney biopsies that reveal chronic lesions (higher S and T scores) are probably less likely to be amendable to immunosuppressive therapy. […] The International IgA Nephropathy Prediction Tool may be used to impute clinical data and MEST-C scores to predict the risk of a 50% decline in estimated glomerular filtration rate (eGFR). […] All patients should be treated with lifestyle modification and maximal RAS blockade, especially if proteinuria is present. […] Prognostication tools are available to balance the risk and benefits of non-immunosuppressive and immunosuppressive therapies.

• #94

  https://journals.lww.com/jasn/fulltext/2024/01000/treatment_of_iga_nephropathy__a_rapidly_evolving.12.aspx

  In addition, remission of proteinuria is associated with improved kidney outcomes, supporting the notion that every effort should be made to reduce proteinuria to 1 g/d. […] Persistent microscopic hematuria thus has emerged as a biomarker of disease activity in IgA nephropathy, independent of proteinuria, but even more so in the presence of proteinuria. […] Each of the components of the revised Oxford classification of IgA nephropathy M=mesangial hypercellularity, E=endocapillary hypercellularity, S=segmental glomerulosclerosis, T=tubular atrophy/interstitial fibrosis, C=crescents (MEST-C) score has been shown to individually predict renal outcome, independent of clinical data. […] Mesangial proliferation, endocapillary proliferation, and crescents are active inflammatory lesions, with the potential to identify high-risk patients who would benefit from immunosuppressive treatment.

• #95 IgA nephropathy | Cleveland Clinic Journal of Medicine

  https://www.ccjm.org/content/90/6_suppl_1/e5

  The International IgA Nephropathy Network and the Renal Pathology Society developed the Oxford MEST-C pathologic scoring system, which should accompany all kidney biopsy reports to help predict kidney outcomes in patients with IgAN. […] Kidney biopsies that reveal chronic lesions (higher S and T scores) are probably less likely to be amendable to immunosuppressive therapy. […] The International IgA Nephropathy Prediction Tool may be used to impute clinical data and MEST-C scores to predict the risk of a 50% decline in estimated glomerular filtration rate (eGFR). […] All patients should be treated with lifestyle modification and maximal RAS blockade, especially if proteinuria is present. […] Prognostication tools are available to balance the risk and benefits of non-immunosuppressive and immunosuppressive therapies.

• #96

  https://journals.lww.com/jasn/fulltext/2024/01000/treatment_of_iga_nephropathy__a_rapidly_evolving.12.aspx

  In addition, remission of proteinuria is associated with improved kidney outcomes, supporting the notion that every effort should be made to reduce proteinuria to 1 g/d. […] Persistent microscopic hematuria thus has emerged as a biomarker of disease activity in IgA nephropathy, independent of proteinuria, but even more so in the presence of proteinuria. […] Each of the components of the revised Oxford classification of IgA nephropathy M=mesangial hypercellularity, E=endocapillary hypercellularity, S=segmental glomerulosclerosis, T=tubular atrophy/interstitial fibrosis, C=crescents (MEST-C) score has been shown to individually predict renal outcome, independent of clinical data. […] Mesangial proliferation, endocapillary proliferation, and crescents are active inflammatory lesions, with the potential to identify high-risk patients who would benefit from immunosuppressive treatment.

• #97 IgA Nephropathy (Berger’s Disease): ERKNet voor Patiënten

  https://www.erknet.org/patients/nl/your-kidney-disease/iga-nephropathy/disease-information

  IgA Nephropathy (IgAN), in past sometimes known as Bergers Disease, is an inflammatory disease of the kidney, the most common primary glomerulonephritis worldwide as well a leading cause of End-Stage Kidney Disease (ESKD). […] IgAN can occur at any age, both in adults and young children. […] The disease is often detected accidentally. Proteinuria (protein in the urine) and/or haematuria (blood in the urine) are found during routine check-ups. […] Tous les patients atteints d’IgAN doivent subir des examens réguliers, en particulier des analyses d’urine, des analyses de sang et une surveillance de la tension artérielle. […] IgAN is one of the most common idiopathic glomerulonephritis in the world. It is estimated that IgAN nephropathy accounts for as much as 15-40% of all primary glomerulopathies.

• #98 IgA Nephropathy (Berger’s Disease): ERKNet for Patients

  https://www.erknet.org/patients/your-kidney-disease/iga-nephropathy/disease-information

  IgAN may also be a part of a systemic disease, called IgA vasculitis (in the past called Schnlein-Henoch vasculitis), where patients exhibit a skin rash, IgAN, joint pain (arthritis) and/or belly pain (arising from an inflamed bowel). […] Tous les patients atteints d’IgAN doivent subir des examens réguliers, en particulier des analyses d’urine, des analyses de sang et une surveillance de la tension artérielle.

• #99 IgA Nephropathy (Berger’s Disease): ERKNet voor Patiënten

  https://www.erknet.org/patients/nl/your-kidney-disease/iga-nephropathy/disease-information

  IgA Nephropathy (IgAN), in past sometimes known as Bergers Disease, is an inflammatory disease of the kidney, the most common primary glomerulonephritis worldwide as well a leading cause of End-Stage Kidney Disease (ESKD). […] IgAN can occur at any age, both in adults and young children. […] The disease is often detected accidentally. Proteinuria (protein in the urine) and/or haematuria (blood in the urine) are found during routine check-ups. […] Tous les patients atteints d’IgAN doivent subir des examens réguliers, en particulier des analyses d’urine, des analyses de sang et une surveillance de la tension artérielle. […] IgAN is one of the most common idiopathic glomerulonephritis in the world. It is estimated that IgAN nephropathy accounts for as much as 15-40% of all primary glomerulopathies.

• #100 IgA Nephropathy (Berger’s Disease): ERKNet for Patients

  https://www.erknet.org/patients/your-kidney-disease/iga-nephropathy/disease-information

  IgAN may also be a part of a systemic disease, called IgA vasculitis (in the past called Schnlein-Henoch vasculitis), where patients exhibit a skin rash, IgAN, joint pain (arthritis) and/or belly pain (arising from an inflamed bowel). […] Tous les patients atteints d’IgAN doivent subir des examens réguliers, en particulier des analyses d’urine, des analyses de sang et une surveillance de la tension artérielle.

• #101 IgA Nephropathy (Berger’s Disease): ERKNet voor Patiënten

  https://www.erknet.org/patients/nl/your-kidney-disease/iga-nephropathy/disease-information

  IgA Nephropathy (IgAN), in past sometimes known as Bergers Disease, is an inflammatory disease of the kidney, the most common primary glomerulonephritis worldwide as well a leading cause of End-Stage Kidney Disease (ESKD). […] IgAN can occur at any age, both in adults and young children. […] The disease is often detected accidentally. Proteinuria (protein in the urine) and/or haematuria (blood in the urine) are found during routine check-ups. […] Tous les patients atteints d’IgAN doivent subir des examens réguliers, en particulier des analyses d’urine, des analyses de sang et une surveillance de la tension artérielle. […] IgAN is one of the most common idiopathic glomerulonephritis in the world. It is estimated that IgAN nephropathy accounts for as much as 15-40% of all primary glomerulopathies.

• #102 IgA Nephropathy (Berger’s Disease): ERKNet for Patients

  https://www.erknet.org/patients/your-kidney-disease/iga-nephropathy/disease-information

  IgAN may also be a part of a systemic disease, called IgA vasculitis (in the past called Schnlein-Henoch vasculitis), where patients exhibit a skin rash, IgAN, joint pain (arthritis) and/or belly pain (arising from an inflamed bowel). […] Tous les patients atteints d’IgAN doivent subir des examens réguliers, en particulier des analyses d’urine, des analyses de sang et une surveillance de la tension artérielle.

• #103

  https://journals.lww.com/jasn/fulltext/2024/01000/treatment_of_iga_nephropathy__a_rapidly_evolving.12.aspx

  In addition, remission of proteinuria is associated with improved kidney outcomes, supporting the notion that every effort should be made to reduce proteinuria to 1 g/d. […] Persistent microscopic hematuria thus has emerged as a biomarker of disease activity in IgA nephropathy, independent of proteinuria, but even more so in the presence of proteinuria. […] Each of the components of the revised Oxford classification of IgA nephropathy M=mesangial hypercellularity, E=endocapillary hypercellularity, S=segmental glomerulosclerosis, T=tubular atrophy/interstitial fibrosis, C=crescents (MEST-C) score has been shown to individually predict renal outcome, independent of clinical data. […] Mesangial proliferation, endocapillary proliferation, and crescents are active inflammatory lesions, with the potential to identify high-risk patients who would benefit from immunosuppressive treatment.

• #104 IgA Nephropathy (Berger’s Disease): ERKNet voor Patiënten

  https://www.erknet.org/patients/nl/your-kidney-disease/iga-nephropathy/disease-information

  The choice of the therapeutic approach varies according to the individual’s condition and in particular the estimated risk of progression to end-stage kidney disease (ESKD). […] A proper early diagnosis may give the opportunity for early treatment and for the improvement of the prognosis. […] Experts recommend giving all patients a chance to participate in new clinical trials, especially patients at high risk of progression.

• #105

  https://journals.lww.com/jasn/fulltext/2024/01000/treatment_of_iga_nephropathy__a_rapidly_evolving.12.aspx

  The ability of histologic markers to predict a benefit of early glucocorticoids on top of RAASi versus RAASi alone is the subject of two ongoing prospective studies in European IgA nephropathy patients. […] The International IgA Nephropathy Prediction Tool calculates the 5-year risk of a 50% decrease in eGFR or development of ESKD, based on a number of clinical (eGFR, BP, proteinuria, age, race/ethnicity, use of RAASi) and histologic (MEST score) variables at the time of kidney biopsy. […] Optimization of supportive care consists of lifestyle modifications with smoking cessation, dietary sodium and protein restriction, weight control and exercise, statins in patients with hypercholesterolemia, BP control, and proteinuria reduction with maximally tolerated RAASi. […] The initial approach to all patients with IgA nephropathy therefore consists of optimization of supportive care for at least 3 months, with the understanding that the 3-month period starts when target BP has been achieved.

• #106

  https://journals.lww.com/jasn/fulltext/2024/01000/treatment_of_iga_nephropathy__a_rapidly_evolving.12.aspx

  The promising results of sparsentan suggest that it also merits inclusion in the algorithm of stepwise optimization of nonimmunologic treatment. […] The Kidney Disease Improving Global Outcome guidelines suggest to start glucocorticoids with caution when proteinuria remains 1 g/d after at least 3 months of optimal supportive care. […] A personalized risk assessment should combine clinical and pathologic data. […] In patients with clinical risk factors for disease progression, the presence of predominantly active proliferative lesions is an indication for immunosuppressive therapy. […] The moderate dose glucocorticoid regimen used in TESTING has demonstrated efficacy and relative safety and seems to be a good choice among the multiple available treatment regimens. […] The chronic or relapsing-remitting nature of IgA nephropathy requires continuous monitoring beyond the initial treatment course. […] The main challenge in the approach to patients with IgA nephropathy is to estimate the degree of disease activity and the extent of preexisting chronic damage and predict the risk of renal function decline from either ongoing inflammation or progression of CKD.

• #107

  https://journals.lww.com/jasn/fulltext/2024/01000/treatment_of_iga_nephropathy__a_rapidly_evolving.12.aspx

  The promising results of sparsentan suggest that it also merits inclusion in the algorithm of stepwise optimization of nonimmunologic treatment. […] The Kidney Disease Improving Global Outcome guidelines suggest to start glucocorticoids with caution when proteinuria remains 1 g/d after at least 3 months of optimal supportive care. […] A personalized risk assessment should combine clinical and pathologic data. […] In patients with clinical risk factors for disease progression, the presence of predominantly active proliferative lesions is an indication for immunosuppressive therapy. […] The moderate dose glucocorticoid regimen used in TESTING has demonstrated efficacy and relative safety and seems to be a good choice among the multiple available treatment regimens. […] The chronic or relapsing-remitting nature of IgA nephropathy requires continuous monitoring beyond the initial treatment course. […] The main challenge in the approach to patients with IgA nephropathy is to estimate the degree of disease activity and the extent of preexisting chronic damage and predict the risk of renal function decline from either ongoing inflammation or progression of CKD.

• #108

  https://journals.lww.com/jasn/fulltext/2024/01000/treatment_of_iga_nephropathy__a_rapidly_evolving.12.aspx

  The promising results of sparsentan suggest that it also merits inclusion in the algorithm of stepwise optimization of nonimmunologic treatment. […] The Kidney Disease Improving Global Outcome guidelines suggest to start glucocorticoids with caution when proteinuria remains 1 g/d after at least 3 months of optimal supportive care. […] A personalized risk assessment should combine clinical and pathologic data. […] In patients with clinical risk factors for disease progression, the presence of predominantly active proliferative lesions is an indication for immunosuppressive therapy. […] The moderate dose glucocorticoid regimen used in TESTING has demonstrated efficacy and relative safety and seems to be a good choice among the multiple available treatment regimens. […] The chronic or relapsing-remitting nature of IgA nephropathy requires continuous monitoring beyond the initial treatment course. […] The main challenge in the approach to patients with IgA nephropathy is to estimate the degree of disease activity and the extent of preexisting chronic damage and predict the risk of renal function decline from either ongoing inflammation or progression of CKD.

• #109 First-in-class treatment delivers major advance for incurable kidney disease | The George Institute for Global Health

  https://www.georgeinstitute.org/news-and-media/news/first-in-class-treatment-delivers-major-advance-for-incurable-kidney-disease

  IgA nephropathy, also known as Bergers disease, is a condition where the antibody immunoglobulin A (IgA) builds up in the kidneys, causing inflammation and scarring. […] This data shows sparsentan was responsible for a rapid and sustained reduction in proteinuria, and this has the potential to prevent progressive kidney function loss in patients with the disease. […] Sparsentan represents a new class of drug that promises great benefit for patients with IgA nephropathy. […] With around 10% of the worlds population being affected by chronic kidney disease, The George Institute for Global Health is committed to addressing the challenges faced by this patient population through improvements to treatment and care.

• #110

  https://journals.lww.com/jasn/fulltext/2024/01000/treatment_of_iga_nephropathy__a_rapidly_evolving.12.aspx

  The promising results of sparsentan suggest that it also merits inclusion in the algorithm of stepwise optimization of nonimmunologic treatment. […] The Kidney Disease Improving Global Outcome guidelines suggest to start glucocorticoids with caution when proteinuria remains 1 g/d after at least 3 months of optimal supportive care. […] A personalized risk assessment should combine clinical and pathologic data. […] In patients with clinical risk factors for disease progression, the presence of predominantly active proliferative lesions is an indication for immunosuppressive therapy. […] The moderate dose glucocorticoid regimen used in TESTING has demonstrated efficacy and relative safety and seems to be a good choice among the multiple available treatment regimens. […] The chronic or relapsing-remitting nature of IgA nephropathy requires continuous monitoring beyond the initial treatment course. […] The main challenge in the approach to patients with IgA nephropathy is to estimate the degree of disease activity and the extent of preexisting chronic damage and predict the risk of renal function decline from either ongoing inflammation or progression of CKD.

• #111 IgA Nephropathy: What Is New in Treatment Options?

  https://www.mdpi.com/2673-8236/4/4/19

  The objectives of IgAN treatment should be to reduce glomerular inflammation and the production of Gd-IgA1 and to enhance supportive therapy as much as possible. […] Strengthening supportive therapy, using glifozines with their established renoprotective effects in addition to the effect of the RAAS blockade, or by the blockade of the RAAS with the new anti-aldosterones such as finerenone, and with dual selective antagonists of the angiotensin II receptor (AT1) and endothelin 1 (ET-1) receptor (ETA), seems promising before the introduction of immunosuppressants, which is often an obligatory path in patients at high risk of progression.

• #112 IgA Nephropathy (Berger’s Disease): ERKNet voor Patiënten

  https://www.erknet.org/patients/nl/your-kidney-disease/iga-nephropathy/disease-information

  The choice of the therapeutic approach varies according to the individual’s condition and in particular the estimated risk of progression to end-stage kidney disease (ESKD). […] A proper early diagnosis may give the opportunity for early treatment and for the improvement of the prognosis. […] Experts recommend giving all patients a chance to participate in new clinical trials, especially patients at high risk of progression.

Zobacz więcej