Materiały źródłowe

• #1

  https://link.springer.com/article/10.1007/s40257-024-00915-7

  Pityriasis rosea (PR) is a prevalent dermatological condition characterized by a distinctive herald patch, followed by secondary eruptions, often forming a Christmas tree pattern on the trunk. […] Epidemiologically, PR affects children, adolescents, and young adults, with a higher incidence in females. […] The condition is observed globally, with varying incidence rates and seasonal variations, suggesting an infectious component. […] In the USA, a study utilizing the All of Us database found that PR affects approximately 0.13% of the population, with a higher prevalence in females and individuals aged 10-29 years. […] Seasonal variations have also been noted, with some studies suggesting a higher incidence during the fall and winter months. […] In Eastern Anatolia, Turkey, a study analyzing 391 patients with PR from 1992 to 1995 reported an average annual incidence of 0.75 per 100 dermatologic patients, with a slightly higher prevalence in females and a peak incidence in the 20-29 year age group.

• #1 Pityriasis Rosea – StatPearls – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK448091/

  The approximate incidence of PR is 0.5% to 2%. The condition affects men and women, but studies reveal it is more commonly seen in women. […] Adolescents and adults between 15 and 30 are most frequently affected, but PR also affects older adults and children. […] More cases of PR are seen in the monsoon and fall seasons.

• #1 Pityriasis Rosea: Diagnosis and Treatment | AAFP

  https://www.aafp.org/pubs/afp/issues/2018/0101/p38.html

  Pityriasis rosea is a common self-limiting rash that usually starts with a herald patch on the trunk and progresses along the Langer lines to a generalized rash over the trunk and limbs. […] The incidence is 170 cases per 100,000 persons per year. […] It typically affects persons 10 to 35 years of age. […] Some studies report that males and females are equally affected, whereas others report that females are affected more often. […] Data on seasonal variation are conflicting, but studies show a higher prevalence during winter. […] The epidemiology and clinical course of pityriasis rosea suggest an infectious etiology. […] Temporal case clustering, which indicates infectious transmission, has been documented in regression analysis models. […] A viral etiology was proposed after intranuclear and intracytoplasmic virus-like particles were observed by microscopy.

• #1 Pityriasis Rosea: Practice Essentials, Pathophysiology, Etiology

  https://emedicine.medscape.com/article/1107532-overview

  Pityriasis rosea (PR) is very common in the general population, and most cases occur in the spring and winter in temperate climates. The estimated frequency of pityriasis rosea in the United States is approximately 0.13% in females and 0.14% in males, with a 0.3-3% prevalence at dermatologic centers. […] Worldwide, pityriasis rosea has been estimated to account for 2% of dermatologic outpatient visits. The disease is more common in the spring and the fall in temperate climate zones. However, it may be more frequent in the summer in some other regions. It favors the hot, dry season in Australia, India, and Malaysia. […] An increase in the prevalence of pityriasis rosea has been reported in Uganda. No change in the prevalence of pityriasis rosea has been reported in Sweden. It has also been seen in the United Kingdom, Nigeria, Sudan, Brazil, Lagos, Singapore, Turkey, Kuwait, and Hong Kong.

• #1 Prevalence of pityriasis rosea in the United States: A cross-sectional study using the All of Us database

  https://pmc.ncbi.nlm.nih.gov/articles/PMC9127562/

  Pityriasis rosea (PR) is a common papulosquamous disease; however, its epidemiology is not well established. Single-center studies, conducted mostly outside the United States, have estimated the prevalence of PR to be 0.39-4.80%; however, there are no published estimates of PR prevalence from a diverse, nationwide cohort of American patients. […] Currently, the All of Us database has enrolled 327,654 participants. We identified 687 patients with PR, representing an overall prevalence of 0.21% (95% CI, 0.19-0.23). […] Altogether, our data suggest PR is a common dermatosis prevalent across all racial groups.

• #1

  https://link.springer.com/article/10.1023/A:1007412330146

  The purpose of this study was to investigate the epidemiological features of pityriasis rosea (PR) in the Eastern Anatolia, Turkey. […] Three hundred ninety-one patients (214 females, 177 males) with PR seen during the years 1992-1995 were analyzed for annual incidence among dermatologic outpatients, sex, age, and distribution by month and year. […] The average annual incidence was 0.75 per 100 dermatologic patients. […] PR was reported to be slightly more common in women by margin of 1.2:1.0. […] Eighty-seven of the cases were between the ages of 10 and 39 years, with a peak in the 20-29 age group. […] The incidence of the disease was much higher in the rainy and snowy months. […] No declining incidence was observed over the years. […] Changes in incidence from year to year, though not great, were statistically significant.

• #1 One-year Review of Pityriasis Rosea at the National Skin Centre, Singapore – Annals Singapore

  https://annals.edu.sg/one-year-review-of-pityriasis-rosea-at-the-national-skin-centre-singapore/

  Pityriasis rosea is a common, acute, self-limited papulosquamous eruption of possible viral aetiology. The aim of this study was to describe the profile of pityriasis rosea seen at a referral skin centre in Singapore. […] A retrospective chart review was conducted of all the patients with a diagnosis of pityriasis rosea seen during 1996. There were 368 patients; their ages ranged from 9 months to 82 years with a peak in the 20 to 29 years age group. […] The clinic incidence was 6.5 per 1000 cases. No ethnic predilection was noted and cases were seen evenly throughout the year. […] The pattern of pityriasis rosea in Singapore is similar to that reported in other countries except for a male predominance and absence of monthly variation. A lower incidence and an older group of patients were also seen in our series as compared to African patients.

• #1 Pityriasis Rosea: Practice Essentials, Pathophysiology, Etiology

  https://emedicine.medscape.com/article/1107532-overview

  Pityriasis rosea is observed in people of all age groups, though it is most common in persons aged 10-35 years and rare in infants and elderly persons. The youngest patient reported in the literature was aged 3 months, and the oldest was aged 85 years. […] Pityriasis rosea occurs slightly more often in females than in males. The female-to-male ratio is reported as 2:1 or 3:2 in the United States. […] No racial predominance is reported. More intensely pigmented Africans tend to have more widespread disease. The lesions in African Americans may lack a rose color, and they may appear darker than the surrounding skin.

• #1

  https://ijmrr.medresearch.in/index.php/ijmrr/article/view/417

  Pityriasis Rosea (PR) is an acute self limiting disorder, thought to represent a viral exanthema. […] A prospective cohort study on the clinico-epidemiological pattern of PR in participants of age group below 15 years was performed over a period of three years. […] Frequency of PR was highest among age group 11 to 15 years (57.5%), followed by 35.6% in age group 5 to 10 years and was lowest among group below 5 years of age (6.9%). […] Seasonal variation was evident, with highest incidence in summer season, followed by winter and rainy season. […] in children incidences of PR increases with the age, it was slightly higher in males and was more common during summer season.

• #1 Pityriasis rosea – An update – Indian Journal of Dermatology, Venereology and Leprology

  https://ijdvl.com/pityriasis-rosea-an-update/

  PR is universal. The incidence is around 0.68 per 100 dermatological patients, or 172.2 per 100,000 person-years. The prevalence in people aged between 10 and 29 years is 0.6%. The male to female ratio is around 1: 1.43. […] Analyzing all patients in nine recent studies, we found an overall incidence of 0.68 per 100 dermatological patients. The community-based incidence of PR was reported to be 172.2 per 100,000 person-years. The prevalence was reported to be 0.6% for young people aged between 10 and 29 years. […] Most patients are between the age of 10 and 35 years. […] Conflicting results were reported for seasonal variation in PR. […] Clusters of cases have been frequently reported. Spatial-temporal and temporal clustering has been reported, offering epidemiological support for an infectious etiology.

• #1 Pityriasis rosea – Wikipedia

  https://en.wikipedia.org/wiki/Pityriasis_rosea

  The overall prevalence of PR in the United States has been estimated to be 0.13% in men and 0.14% in women. It most commonly occurs between the ages of 10 and 35. It is more common in spring. […] PR is not viewed as contagious, though there have been reports of small epidemics in fraternity houses and military bases, schools and gyms.

• #1

  https://link.springer.com/article/10.1007/s40257-024-00915-7

  The incidence was notably higher during the rainy and snowy months. […] In Kaduna, Nigeria, PR was found in approximately 2.4% of dermatology clinic attendees, with a significant number of cases occurring during the rainy season. […] Understanding the epidemiological patterns and clinical manifestations of PR is crucial for effective diagnosis and patient reassurance, as well as for guiding future research on its underlying causes and potential treatments.

• #1 Pityriasis Rosea | AAFP

  https://www.aafp.org/pubs/afp/issues/2004/0101/p87.html

  Pityriasis rosea is a common, acute exanthem of uncertain etiology. […] Pityriasis rosea typically affects children and young adults. […] Several large case series from dermatology practices indicate that the incidence of pityriasis rosea peaks in persons 20 to 29 years of age, with no consistent gender predilection. […] First, outbreaks of the condition occur in clusters, suggesting that an infectious agent is circulating within a community. […] Recurrence of pityriasis rosea outside the acute phase is rare, suggesting that there is long-lasting immunity after the infection. […] Worsening of the rash or a second wave of lesions is not uncommon before eventual spontaneous resolution of the eruption. Recurrence of the condition later in life is rare.

• #1 Pityriasis Rosea: Diagnosis and Treatment | AAFP

  https://www.aafp.org/pubs/afp/issues/2018/0101/p38.html

  The most common viruses linked to pityriasis rosea are human herpesvirus-6 and -7 (HHV-6 and -7). […] However, the studies linking HHV-6 and -7 with pityriasis rosea are conflicting and small. […] Early polymerase chain reaction studies did not detect active viral DNA in patients with pityriasis rosea, despite their having positive antibodies to HHV-6 and -7. […] A later study using a calibrated quantitative real-time polymerase chain reaction assay found active HHV-6 and -7 in plasma and skin samples. […] Electron microscopy detected HHV particles in various stages of morphogenesis in 71% of the 21 patients studied.

• #1

  https://journals.lww.com/idoj/fulltext/2018/09060/pityriasis_rosea__clinical_profile_from_central.8.aspx

  It is rare in both the very young (less than 2 years) and the elderly (more than 65 years). […] Recurrences of PR are rare, which suggests lasting immunity after an initial episode of PR. […] Up to 69% of patients with PR have a prodromal illness before the herald patch appears. […] A history of a herald patch and a few characteristic lesions in a Christmas tree pattern aid the diagnosis of typical PR. […] Atypical variants of PR are rare and occur in only 20% of cases. […] PR can be atypical with respect to morphology, size, distribution, number, site, and course of disease. […] Our study comprised four patients with EM-like lesions. […] The clinical features of the cases in this study were mostly in accordance with the classical pattern of PR. […] This is the first study of PR from Central India. […] We suggest that studies should be conducted from various parts of the country, to see the similarities and differences in the trend of epidemiology and presentation of PR in India.

• #1

  https://step2.medbullets.com/dermatology/120085/pityriasis-rosea

  Epidemiology […] Children […] Young adults […] Rare above 35 years of age […] […] […] Typically self-limited and self-resolving in 4-12 weeks

• #1 Pityriasis rosea: a distinct entity or viral exanthem?

  https://www.termedia.pl/Pityriasis-rosea-a-distinct-entity-or-viral-exanthem-,56,54777,1,1.html

  Pityriasis rosea affects approximately 0.56% of the population, mostly people between 10 to 35 years old, but it can occur in younger and older patients as well. […] The female : male ratio varies from no significant difference between sexes to 1.5 : 1 female : male ratio. […] PR occurs mainly during cold seasons, however, there are studies which showed that PR occurs uniformly during the year. […] PR may recur in around 3% of the patients. In majority of relapsing cases, it reoccurs only once, although there are reported cases with a multiple recurrence rate.

• #1 Pityriasis Rosea – Dermatologic Disorders – Merck Manual Professional Edition

  https://www.merckmanuals.com/professional/dermatologic-disorders/psoriasis-and-scaling-diseases/pityriasis-rosea

  Pityriasis rosea most commonly occurs between ages 10 and 35. It affects women more often. […] Pityriasis rosea during the first 15 weeks of pregnancy is associated with premature birth or fetal demise. […] Pregnant women should be offered antiviral therapy, even though this has not proved to reduce obstetric complications.

• #1 Pityriasis Rosea

  https://mobile.fpnotebook.com/Derm/Hyperplasia/PtyrsRs.htm

  Incidence: 170 per 100,000 persons/year […] Ages 10 to 50 years (peaks age 20 to 30 years) […] No gender predisposition […] Seasonal variation: more common in spring and fall […] Higher risk in pregnancy (RR 3) […] Associated with increased Miscarriage rate before 15 weeks gestation.

• #1 Pityriasis rosea-like adverse reaction: Review of the literature and experience of an Italian drug-surveillance center

  https://escholarship.org/uc/item/80d8301d

  Pityriasis rosea is a common, acute eruption of uncertain etiology. […] A prospective study to record all cases of adverse cutaneous reactions presenting with pityriasis rosea like manifestations was conducted at the center for drug-surveillance of the dermatology department of Cagliari University. […] Frequency of drug pityriasis rosea-like eruptions is probably underreported. […] The mildness of the eruption, mimicking a very common and self-limiting disease does not prompt physicians to verify the use of medications until persistence, severity of lesions and itching require re-evaluation of the original diagnosis. […] The frequency of pityriasis rosea-like eruptions in our case reports, compared to the overall number of adverse cutaneous reactions (2 %) is remarkable and suggests underreporting.

• #1 Pityriasis rosea-like adverse reaction: Review of the literature and experience of an Italian drug-surveillance center

  https://escholarship.org/uc/item/80d8301d

  The clinical suspicion of an iatrogenic etiology was confirmed by the sudden recovery after withdrawal of the drug (dechallenge). […] Responsibility of ACE inhibitors seems to be more frequent than that of other drugs. […] After our first case description we hypothesized that the frequency of drug-related pityriasis rosea-like eruptions is underreported, and we conducted a prospective study collecting all new cases observed in our department. […] Misdiagnosis and consequent waiting for pityriasis rosea self-healing should have further prolonged illness and caused a notable delay in adopting the more important measure, which is discontinuation of the drug.

• #1 A Case of Pityriasis Rosea Following Monkeypox Vaccination | SKIN The Journal of Cutaneous Medicine

  https://skin.dermsquared.com/skin/article/view/1763

  Pityriasis rosea (PR) is a well-known but uncommon, benign papulosquamous skin condition that often occurs after viral infections or vaccinations. […] Given the known association of smallpox and PR, PR reactions following MPX vaccination may occur.

• #1 Herald Patch as the Only Evidence of Pityriasis Rosea: Clinical, Laboratory and Pathogenetic Features

  https://www.mdpi.com/1999-4915/17/1/119

  Pityriasis rosea (PR) is an acute, self-limited exanthematous disease that primarily affects children and young adults between 10 and 35 years of age. The disease is widespread across disparate populations, with a global incidence of 0.64 per 100 dermatological patients and a slight female prevalence. A large body of evidence supports the causal role of the endogenous systemic active human herpesvirus (HHV)-6 and HHV-7 infections in PR pathogenesis. The prevalence of these atypical variants of PR may be underestimated. The clinical and laboratory features of PR characterized by the HP without the secondary eruption have been poorly investigated. The present work aimed to investigate the clinical and laboratory features of PR with HP as the unique manifestation of the disease and to compare this rare variant of PR with the classic one. Between January 2003 and December 2023, we collected data from 964 patients with different forms of PR. Twenty-seven patients presented HP as the only evidence of PR (2.8%). Still, we recruited only nineteen of them (2%), eleven males (57.8%) and eight females (42.2%) with a mean age of 27.1 years, who had completed all microbiological investigations. The findings of our study may suggest some pathogenic mechanisms that could explain the clinical differences between this form of atypical PR and classical PR. Therefore, an attempt to explain the pathogenesis of PR characterized only by the HP is the hypothesis that it could be considered an abortive form of the disease that happens when the HHV-6 and/or HHV-7 reactivation from latency is countered by an immunological response that is more effective than in classic PR. […] The diagnosis remains mainly clinical, as in the cases of classic PR. Laboratory investigations and histopathology are advisable in doubtful cases. Dermatologists should be aware of this rare variant of PR and be well-trained to consider other possible differential diagnoses.

• #1 Pityriasis Rosea | 5-Minute Clinical Consult

  https://www.unboundmedicine.com/5minute/view/5-Minute-Clinical-Consult/816371/all/Pityriasis_Rosea

  Predominant age: 10 to 35 years but occurs in all age groups. […] Predominant sex: male = female. […] Some studies have shown a slight female preponderance. […] No racial predominance. […] Relatively common, but exact frequency is unknown; one study noted 170 out of 100,000 yearly incidence.

• #1 Pityriasis rosea – Altmeyers Encyclopedia – Department Dermatology

  https://www.altmeyers.org/en/dermatology/pityriasis-rosea-120752

  Common clinical picture with a prevalence of 0.1%. […] Occurring in healthy individuals between the ages of 10-35 years (Leung AKC et al. 2021). […] Equal occurrence worldwide. Endemic occurrence possible especially in spring and autumn. […] In a larger study in dark-skinned individuals (n=50), differences in progression and progenosis are evident (Amer A et al. 2007).

• #2 Pityriasis Rosea | Plastic Surgery Key

  https://plasticsurgerykey.com/pityriasis-rosea-4/

  PR is reported in all races throughout the world, irrespective of climate. The average annual incidence at one center was reported to be 0.16% (158.9 cases per 100,000 person-years). […] Although PR is usually considered to be more common in the spring and fall months in temperate zones, seasonal variation has not been borne out in studies performed in other parts of the world. Clustering of cases can occur and has been used to support an infectious etiology for PR, although this is not a consistent feature observed in all communities. […] Most studies have shown a slight female preponderance of approximately 1.5:1. PR most commonly occurs between the ages of 10 and 35 years. It is rare before age 2 years and after age 65 years. Recurrences of PR are rare, which suggests lasting immunity after an initial episode of PR.

• #2 Pityriasis rosea – DermNet

  https://dermnetnz.org/topics/pityriasis-rosea

  Pityriasis rosea is most common in teenagers and young adults (10-35 year-olds), however it can affect people of any age. […] Approximate incidence of 0.5% to 2%. […] Most cases occur in winter.

• #2 Pityriasis Rosea

  https://mobile.fpnotebook.com/Derm/Hyperplasia/PtyrsRs.htm

  Incidence: 170 per 100,000 persons/year […] Ages 10 to 50 years (peaks age 20 to 30 years) […] No gender predisposition […] Seasonal variation: more common in spring and fall […] Higher risk in pregnancy (RR 3) […] Associated with increased Miscarriage rate before 15 weeks gestation.

• #2 Pityriasis rosea – Wikipedia

  https://en.wikipedia.org/wiki/Pityriasis_rosea

  The overall prevalence of PR in the United States has been estimated to be 0.13% in men and 0.14% in women. It most commonly occurs between the ages of 10 and 35. It is more common in spring. […] PR is not viewed as contagious, though there have been reports of small epidemics in fraternity houses and military bases, schools and gyms.

• #2 Pityriasis Rosea: Diagnosis and Treatment | AAFP

  https://www.aafp.org/pubs/afp/issues/2018/0101/p38.html

  Pityriasis rosea is a common self-limiting rash that usually starts with a herald patch on the trunk and progresses along the Langer lines to a generalized rash over the trunk and limbs. […] The incidence is 170 cases per 100,000 persons per year. […] It typically affects persons 10 to 35 years of age. […] Some studies report that males and females are equally affected, whereas others report that females are affected more often. […] Data on seasonal variation are conflicting, but studies show a higher prevalence during winter. […] The epidemiology and clinical course of pityriasis rosea suggest an infectious etiology. […] Temporal case clustering, which indicates infectious transmission, has been documented in regression analysis models. […] A viral etiology was proposed after intranuclear and intracytoplasmic virus-like particles were observed by microscopy.

• #2 Pityriasis Rosea | Obgyn Key

  https://obgynkey.com/pityriasis-rosea-2/

  Pityriasis rosea is a papulosquamous eruption of unknown etiology. It occurs throughout the life cycle. It is most commonly seen between the ages of 10 and 35 years. The peak incidence is between 20 and 29 years of age. The gender distribution is essentially equal. The rash is most prevalent in winter months. […] Despite the long history, its etiology remains elusive. A number of infectious etiologies have been proposed, but at present, supporting evidence is inconclusive.

• #2

  https://journals.lww.com/idoj/fulltext/2018/09060/pityriasis_rosea__clinical_profile_from_central.8.aspx

  It is rare in both the very young (less than 2 years) and the elderly (more than 65 years). […] Recurrences of PR are rare, which suggests lasting immunity after an initial episode of PR. […] Up to 69% of patients with PR have a prodromal illness before the herald patch appears. […] A history of a herald patch and a few characteristic lesions in a Christmas tree pattern aid the diagnosis of typical PR. […] Atypical variants of PR are rare and occur in only 20% of cases. […] PR can be atypical with respect to morphology, size, distribution, number, site, and course of disease. […] Our study comprised four patients with EM-like lesions. […] The clinical features of the cases in this study were mostly in accordance with the classical pattern of PR. […] This is the first study of PR from Central India. […] We suggest that studies should be conducted from various parts of the country, to see the similarities and differences in the trend of epidemiology and presentation of PR in India.

• #2 Pityriasis Rosea | 5-Minute Clinical Consult

  https://www.unboundmedicine.com/5minute/view/5-Minute-Clinical-Consult/816371/all/Pityriasis_Rosea

  Predominant age: 10 to 35 years but occurs in all age groups. […] Predominant sex: male = female. […] Some studies have shown a slight female preponderance. […] No racial predominance. […] Relatively common, but exact frequency is unknown; one study noted 170 out of 100,000 yearly incidence.

• #2 Pityriasis rosea – An update – Indian Journal of Dermatology, Venereology and Leprology

  https://ijdvl.com/pityriasis-rosea-an-update/

  PR is universal. The incidence is around 0.68 per 100 dermatological patients, or 172.2 per 100,000 person-years. The prevalence in people aged between 10 and 29 years is 0.6%. The male to female ratio is around 1: 1.43. […] Analyzing all patients in nine recent studies, we found an overall incidence of 0.68 per 100 dermatological patients. The community-based incidence of PR was reported to be 172.2 per 100,000 person-years. The prevalence was reported to be 0.6% for young people aged between 10 and 29 years. […] Most patients are between the age of 10 and 35 years. […] Conflicting results were reported for seasonal variation in PR. […] Clusters of cases have been frequently reported. Spatial-temporal and temporal clustering has been reported, offering epidemiological support for an infectious etiology.

• #2 Pityriasis Rosea: Practice Essentials, Pathophysiology, Etiology

  https://emedicine.medscape.com/article/1107532-overview

  Pityriasis rosea (PR) is very common in the general population, and most cases occur in the spring and winter in temperate climates. The estimated frequency of pityriasis rosea in the United States is approximately 0.13% in females and 0.14% in males, with a 0.3-3% prevalence at dermatologic centers. […] Worldwide, pityriasis rosea has been estimated to account for 2% of dermatologic outpatient visits. The disease is more common in the spring and the fall in temperate climate zones. However, it may be more frequent in the summer in some other regions. It favors the hot, dry season in Australia, India, and Malaysia. […] An increase in the prevalence of pityriasis rosea has been reported in Uganda. No change in the prevalence of pityriasis rosea has been reported in Sweden. It has also been seen in the United Kingdom, Nigeria, Sudan, Brazil, Lagos, Singapore, Turkey, Kuwait, and Hong Kong.

• #2 Pityriasis Rosea | Enhanced Dental CPD Online

  https://www.dentaljuce.com/shorts-pityriasis-rosea

  The prevalence of pityriasis rosea in the United States is approximately 0.13% in men and 0.14% in women, with higher incidence during spring. The condition is not considered contagious, although small outbreaks have been reported in communal settings like fraternity houses, military bases, and schools.

• #2 Pityriasis rosea – evidence for and against an infectious aetiology | Epidemiology & Infection | Cambridge Core

  https://www.cambridge.org/core/journals/epidemiology-and-infection/article/pityriasis-rosea-evidence-for-and-against-an-infectious-aetiology/D5BE6C6630EB64BEA0CF1C72AAFC0829

  Pityriasis rosea, first named as such in 1860, probably holds the longest record for an exanthem suspected to be associated with an infection but for which an exact cause has not been found. The distinctly programmed clinical course, the lack of recurrence for most patients, and the presence of temporal case clustering provide the strongest evidence to support an infectious aetiology. Further support comes from seasonal variation and the association with respiratory tract infections, the unfavourable social and economic background of cases, and a history in some cases of contact with patients with pityriasis rosea. […] The apparent therapeutic efficacy of several treatment modalities does not provide strong evidence for or against an infectious aetiology. The roles of human herpesvirus 7 and to a lesser extent human herpesvirus 6 remain controversial. There exists reasonable evidence that pityriasis rosea is not associated with cytomegalovirus, EpsteinBarr virus, parvovirus B19, picornavirus, influenza and parainfluenza viruses, Legionella spp., Mycoplasma spp. and Chlamydia spp. infections. Evidence is also unsubstantiated as yet for alternative aetiological hypotheses such as autoimmunity, atopy, and genetic predisposition.

• #2 Pityriasis Rosea | AAFP

  https://www.aafp.org/pubs/afp/issues/2004/0101/p87.html

  Pityriasis rosea is a common, acute exanthem of uncertain etiology. […] Pityriasis rosea typically affects children and young adults. […] Several large case series from dermatology practices indicate that the incidence of pityriasis rosea peaks in persons 20 to 29 years of age, with no consistent gender predilection. […] First, outbreaks of the condition occur in clusters, suggesting that an infectious agent is circulating within a community. […] Recurrence of pityriasis rosea outside the acute phase is rare, suggesting that there is long-lasting immunity after the infection. […] Worsening of the rash or a second wave of lesions is not uncommon before eventual spontaneous resolution of the eruption. Recurrence of the condition later in life is rare.

• #2 Pityriasis Rosea: An Updated Review

  https://www.eurekaselect.com/article/110184

  Pityriasis rosea occurs mainly in individuals between 10 and 35 years of age with a peak during adolescence. […] Human herpesvirus (HHV)-7 and HHV-6 have been implicated as the causative agents in some patients with pityriasis rosea. […] Pityriasis rosea in the absence of the herald patch and its variants may pose a diagnostic challenge. […] Clinical variants of the disease may pose a diagnostic challenge for the general pediatrician. Knowledge of the disease is essential to allow prompt diagnosis and to avoid unnecessary investigations.

• #2 Pityriasis rosea: MedlinePlus Medical EncyclopediaLock

  https://medlineplus.gov/ency/article/000871.htm

  Pityriasis rosea is a common type of skin rash most often seen in young adults. […] Pityriasis rosea is believed to be caused by a virus. It occurs most often in the fall and spring. […] Although pityriasis rosea may occur in more than one person in a household at a time, it is not thought to spread from one person to another. Females seem to be more affected than males. […] Pityriasis rosea often goes away within 4 to 8 weeks. It usually doesn’t come back. […] Contact your provider for an appointment if you have symptoms of pityriasis rosea.

• #2 Prevalence of pityriasis rosea in the United States: A cross-sectional study using the All of Us database

  https://pmc.ncbi.nlm.nih.gov/articles/PMC9127562/

  Pityriasis rosea (PR) is a common papulosquamous disease; however, its epidemiology is not well established. Single-center studies, conducted mostly outside the United States, have estimated the prevalence of PR to be 0.39-4.80%; however, there are no published estimates of PR prevalence from a diverse, nationwide cohort of American patients. […] Currently, the All of Us database has enrolled 327,654 participants. We identified 687 patients with PR, representing an overall prevalence of 0.21% (95% CI, 0.19-0.23). […] Altogether, our data suggest PR is a common dermatosis prevalent across all racial groups.

• #3 Pityriasis Rosea – Dermpath Diagnostics

  https://www.dermpathdiagnostics.com/clinicians/pityriasis-rosea/

  Prevalence of 0.13% in men and 0.14% in women in the United States.

• #3 Pityriasis Rosea: Practice Essentials, Pathophysiology, Etiology

  https://emedicine.medscape.com/article/1107532-overview

  Pityriasis rosea is observed in people of all age groups, though it is most common in persons aged 10-35 years and rare in infants and elderly persons. The youngest patient reported in the literature was aged 3 months, and the oldest was aged 85 years. […] Pityriasis rosea occurs slightly more often in females than in males. The female-to-male ratio is reported as 2:1 or 3:2 in the United States. […] No racial predominance is reported. More intensely pigmented Africans tend to have more widespread disease. The lesions in African Americans may lack a rose color, and they may appear darker than the surrounding skin.

• #3 Pityriasis Rosea | Concise Medical Knowledge

  https://www.lecturio.com/concepts/pityriasis-rosea/

  Incidence: 0.5%2% […] Common age group: 15-30 years […] Seasonal variation: more common in winter and spring (in temperate climates)

• #3 Pityriasis Rosea | Plastic Surgery Key

  https://plasticsurgerykey.com/pityriasis-rosea-4/

  PR is reported in all races throughout the world, irrespective of climate. The average annual incidence at one center was reported to be 0.16% (158.9 cases per 100,000 person-years). […] Although PR is usually considered to be more common in the spring and fall months in temperate zones, seasonal variation has not been borne out in studies performed in other parts of the world. Clustering of cases can occur and has been used to support an infectious etiology for PR, although this is not a consistent feature observed in all communities. […] Most studies have shown a slight female preponderance of approximately 1.5:1. PR most commonly occurs between the ages of 10 and 35 years. It is rare before age 2 years and after age 65 years. Recurrences of PR are rare, which suggests lasting immunity after an initial episode of PR.

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