Materiały źródłowe

• #1 Pancreatic Neuroendocrine Tumors – Information – OHC

  https://ohcare.com/condition/pancreatic-neuroendocrine-tumors/

  Pancreatic neuroendocrine tumors form in hormone-making cells (islet cells) of the pancreas. […] Pancreatic neuroendocrine tumors (NETs) may be benign (not cancer) or malignant (cancer). […] When pancreatic NETs are malignant, they are called pancreatic endocrine cancer or islet cell carcinoma. […] Pancreatic NETs are much less common than pancreatic exocrine tumors and have a better prognosis. […] There are six types of standard treatment. Your OHC doctor will help you determine the best care plan for you. […] Surgery: An operation may be done to remove the tumor […] Chemotherapy: a cancer treatment that uses drugs to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing […] Hormone therapy is a cancer treatment that removes hormones or blocks their action and stops cancer cells from growing

• #2 Expert Neuroendocrine Tumor Care | Henry Ford Health – Detroit, MI

  https://www.henryford.com/services/neuroendocrine

  Fewer than 5% of tumors arising in the pancreas are neuroendocrine tumors. Fortunately, most of these neuroendocrine tumors are slow growing and significantly less aggressive than the common variety pancreatic cancers that are called adenocarcinomas. […] Our multidisciplinary team works together to diagnose and treat your condition. Our neuroendocrine clinic brings together experts in gastroenterology, endocrinology, pulmonology, surgical oncology, transplant surgery, interventional radiology, medical oncology, nuclear medicine and other specialties. […] Once a neuroendocrine tumor is identified and located, you may need surgery to remove most or all of the tumor. Our cancer surgeons who specialize in gastroenterology, pulmonology and pancreatic surgery (among other specialties) are experienced in performing the most complex procedures. […] Given the complexity of neuroendocrine tumors, an accurate diagnosis is critical to ensuring the most effective treatment. We offer the most advanced imaging and diagnostic procedures available.

• #3

  http://www.bccancer.bc.ca/books/neuroendocrine-tumors/pancreatic-neuroendocrine-tumors

  Pancreatic NETs are uncommon with an annual incidence of 0.4-1.2 per 100,000 population. The endocrine cells give rise to pNETs which account for less than 4% of pancreatic neoplasms. The tumours can occur at any age and both sexes are affected equally. pNETs can occur as part of 4 inherited disorders, including Multiple Endocrine Neoplasia type 1 (MEN1), von Hippel-Lindau disease (VHL), neurofibromatosis 1 (NF-1; von Recklinghausen disease) and tuberous sclerosis complex (TSC) with the most common association, up to 80%, in MEN1 patients. Current terminology divides pNETs into: Non-functional tumours – often present in a manner similar to adenocarcinomas of the pancreas […] Functional tumours – excess hormone production results in clinical syndromes (e.g. sometimes in the context of a 'carcinoid syndrome’, characterized by facial flushing, diarrhea, bronchial constriction caused by high levels of circulating serotonin). Other syndromes occur as a result of different hormones being produced, for example: Insulinomas, Gastrinomas, VIPomas, Somatostatinomas, Glucagonomas.

• #4 Expert Neuroendocrine Tumor Care | Henry Ford Health – Detroit, MI

  https://www.henryford.com/services/neuroendocrine

  Fewer than 5% of tumors arising in the pancreas are neuroendocrine tumors. Fortunately, most of these neuroendocrine tumors are slow growing and significantly less aggressive than the common variety pancreatic cancers that are called adenocarcinomas. […] Our multidisciplinary team works together to diagnose and treat your condition. Our neuroendocrine clinic brings together experts in gastroenterology, endocrinology, pulmonology, surgical oncology, transplant surgery, interventional radiology, medical oncology, nuclear medicine and other specialties. […] Once a neuroendocrine tumor is identified and located, you may need surgery to remove most or all of the tumor. Our cancer surgeons who specialize in gastroenterology, pulmonology and pancreatic surgery (among other specialties) are experienced in performing the most complex procedures. […] Given the complexity of neuroendocrine tumors, an accurate diagnosis is critical to ensuring the most effective treatment. We offer the most advanced imaging and diagnostic procedures available.

• #5

  http://www.bccancer.bc.ca/books/neuroendocrine-tumors/pancreatic-neuroendocrine-tumors

  Pancreatic NETs are uncommon with an annual incidence of 0.4-1.2 per 100,000 population. The endocrine cells give rise to pNETs which account for less than 4% of pancreatic neoplasms. The tumours can occur at any age and both sexes are affected equally. pNETs can occur as part of 4 inherited disorders, including Multiple Endocrine Neoplasia type 1 (MEN1), von Hippel-Lindau disease (VHL), neurofibromatosis 1 (NF-1; von Recklinghausen disease) and tuberous sclerosis complex (TSC) with the most common association, up to 80%, in MEN1 patients. Current terminology divides pNETs into: Non-functional tumours – often present in a manner similar to adenocarcinomas of the pancreas […] Functional tumours – excess hormone production results in clinical syndromes (e.g. sometimes in the context of a 'carcinoid syndrome’, characterized by facial flushing, diarrhea, bronchial constriction caused by high levels of circulating serotonin). Other syndromes occur as a result of different hormones being produced, for example: Insulinomas, Gastrinomas, VIPomas, Somatostatinomas, Glucagonomas.

• #6 Pancreatic Neuroendocrine Tumors (NETs) Pancreatic Cancer | Symptoms, Diagnosis & Treatment | MD Anderson Cancer Center

  https://www.mdanderson.org/cancer-types/pancreatic-cancer/pancreatic-neuroendocrine-tumors.html

  Pancreatic NETs are subdivided into two main types, functional and non-functional. […] Non-functional pancreatic NETs do not produce large amounts of hormones. This means that these tumors can grow or spread without causing noticeable symptoms. When symptoms do occur, they can include: […] The best way to treat pancreatic NETs that are contained within the pancreas is through surgery. Many cases can be cured this way. The type of surgical procedure used varies depending on the type, size and location of the tumor. […] Hormone therapy can be used when surgery is not possible. This therapy uses somatostatin analogues, such as octreotide or lanreotide, to slow a tumors growth. It can also be used to prevent the cancer from spreading. […] Chemotherapy can be used to stop a tumor from growing, and to shrink larger tumors.

• #7 Pancreatic Neuroendocrine Tumors (Islet Cell) | Memorial Sloan Kettering Cancer Center

  https://www.mskcc.org/cancer-care/types/gastrointestinal-neuroendocrine/pancreatic-neuroendocrine-islet-cell-tumors

  Pancreatic neuroendocrine tumors (also known as islet cell tumors or islet cell carcinoma) are a type of neuroendocrine tumor found in the pancreas. […] Some pancreatic neuroendocrine tumors are functional, which means they produce excess hormones that can lead to a variety of hormone-related symptoms. (Nonfunctional tumors do not produce hormones.) […] Treatment of pancreatic neuroendocrine tumors may include a combination of surgery, hormone therapy, radiation therapy, and chemotherapy. […] Surgical removal of the tumor is considered the most effective treatment for islet cell tumors. […] Patients with functional pancreatic neuroendocrine tumors that cannot be surgically removed may benefit from monthly injections of octreotide, a synthetic hormone that controls hormone-related symptoms and may have the potential to slow tumor growth.

• #8 FAQ About Neuroendocrine and Carcinoid Tumors | Dana-Farber Cancer Institute

  https://www.dana-farber.org/cancer-care/treatment/gastrointestinal/programs/neuroendocrine-carcinoid/faq

  Neuroendocrine tumors can be classified according to their site of origin, usually either pancreatic neuroendocrine tumors (which start in the pancreas) or carcinoid tumors (which start in other organs). […] Pancreatic neuroendocrine tumors may arise either sporadically, or less commonly, in patients with multiple endocrine neoplasia type I (MEN 1) and other inherited syndromes. About one-third of pancreatic neuroendocrine tumors secrete hormones, including insulin, glucagon, gastrin, or vasoactive intestinal peptide. […] Surgery: When neuroendocrine tumors are found at an early stage (before cancer has spread to other organs), they can usually be removed surgically. In most cases, treatment with chemotherapy or radiation therapy after surgery is not necessary, and patients can be monitored with blood tests and scans.

• #9 Pancreatic Neuroendocrine Tumors (NETs) Pancreatic Cancer | Symptoms, Diagnosis & Treatment | MD Anderson Cancer Center

  https://www.mdanderson.org/cancer-types/pancreatic-cancer/pancreatic-neuroendocrine-tumors.html

  Pancreatic NETs are subdivided into two main types, functional and non-functional. […] Non-functional pancreatic NETs do not produce large amounts of hormones. This means that these tumors can grow or spread without causing noticeable symptoms. When symptoms do occur, they can include: […] The best way to treat pancreatic NETs that are contained within the pancreas is through surgery. Many cases can be cured this way. The type of surgical procedure used varies depending on the type, size and location of the tumor. […] Hormone therapy can be used when surgery is not possible. This therapy uses somatostatin analogues, such as octreotide or lanreotide, to slow a tumors growth. It can also be used to prevent the cancer from spreading. […] Chemotherapy can be used to stop a tumor from growing, and to shrink larger tumors.

• #10

  http://www.bccancer.bc.ca/books/neuroendocrine-tumors/pancreatic-neuroendocrine-tumors

  Pancreatic NETs are uncommon with an annual incidence of 0.4-1.2 per 100,000 population. The endocrine cells give rise to pNETs which account for less than 4% of pancreatic neoplasms. The tumours can occur at any age and both sexes are affected equally. pNETs can occur as part of 4 inherited disorders, including Multiple Endocrine Neoplasia type 1 (MEN1), von Hippel-Lindau disease (VHL), neurofibromatosis 1 (NF-1; von Recklinghausen disease) and tuberous sclerosis complex (TSC) with the most common association, up to 80%, in MEN1 patients. Current terminology divides pNETs into: Non-functional tumours – often present in a manner similar to adenocarcinomas of the pancreas […] Functional tumours – excess hormone production results in clinical syndromes (e.g. sometimes in the context of a 'carcinoid syndrome’, characterized by facial flushing, diarrhea, bronchial constriction caused by high levels of circulating serotonin). Other syndromes occur as a result of different hormones being produced, for example: Insulinomas, Gastrinomas, VIPomas, Somatostatinomas, Glucagonomas.

• #11 Neuroendocrine Tumor Care | Rush

  https://www.rush.edu/services/neuroendocrine-tumor-care

  Our surgical oncologists are experts in treating neuroendocrine tumors surgically, using minimally invasive approaches whenever possible. […] If your neuroendocrine tumors have been linked to hereditary conditions such as multiple endocrine neoplasia, Von Hippel-Lindau syndrome, neurofibromatosis type 1 or tuberous sclerosis, our cancer genetic counselors and specialists can help you determine the next steps. […] Because neuroendocrine tumors are complex, you’ll have a team of specialists working together throughout your care. […] You’ll also have a dedicated team of nurses who are readily available to answer your questions and coordinate your appointments. […] In some cases, your care team may recommend genetic testing to further tailor your treatment plan. […] Rush works with ReVital Cancer Rehabilitation to provide you with the care and tools you need to address pain, fatigue and decreased activity levels during and after neuroendocrine tumor treatment.

• #12 Pancreatic Cancer: Nursing Diagnoses, Care Plans, Assessment & Interventions | NurseTogether

  https://www.nursetogether.com/pancreatic-cancer-nursing-diagnosis-care-plan/

  Nurses provide symptomatic and supportive care to patients diagnosed with pancreatic cancer with interventions like administering medications, providing comfort measures, offering psychological support, ensuring adequate nutrition, and providing patient education and resources. […] Nursing interventions and care are essential for the patients recovery. In the following section, you’ll learn more about possible nursing interventions for a patient with pancreatic cancer. […] Palliative care is not curative and focuses on managing symptoms and pain for improved quality of life. This can be achieved through surgical procedures, nutritional support, chemotherapy, and more. […] Patients with pancreatic carcinoma frequently exhibit weight loss due to anorexia (loss of appetite), as do most patients with advanced malignancy.

• #13 Treating Pancreatic Neuroendocrine Tumors | American Cancer Society

  https://www.cancer.org/cancer/types/pancreatic-neuroendocrine-tumor/treating.html

  For pancreatic neuroendocrine tumors (NETs), treatment options might include surgery, ablation or embolization treatments, radiation therapy, or different types of medicines. […] Many other specialists may be involved in your care as well, including nurse practitioners, nurses, psychologists, social workers, rehabilitation specialists, and other health professionals. […] Its important to discuss all of your treatment options, including their goals and possible side effects, with your doctors to help make the decision that best fits your needs. […] Be sure to talk to your cancer care team about any method you are thinking about using. They can help you learn what is known (or not known) about the method, which can help you make an informed decision. […] People with cancer need support and information, no matter what stage of illness they may be in. Knowing all of your options and finding the resources you need will help you make informed decisions about your care.

• #14 Pancreatic neuroendocrine tumors – Care at Mayo Clinic – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/pancreatic-neuroendocrine-tumors/care-at-mayo-clinic/mac-20352492

  Mayo Clinic doctors are among the most experienced in diagnosing and treating pancreatic neuroendocrine tumors, which are very rare. […] Each year they care for more than 600 people with pancreatic neuroendocrine tumors, providing comprehensive care using cutting-edge technology and the latest in treatment advances, including many advances that Mayo Clinic doctors helped develop. […] At Mayo Clinic, you’ll receive coordinated care from a team of doctors and health care professionals, including experts who work in the Pancreas Clinic. […] Mayo Clinic offers a truly integrated practice, with a variety of specialists regularly working together and meeting to discuss cases. […] Your care team carefully weighs all of your treatment options to create a plan that’s personalized for you. […] Mayo Clinic doctors have access to the newest radiologic imaging and other diagnostic technology and treatments to improve chances for positive outcomes.

• #15 Pancreatic Neuroendocrine Tumors | Types and Treatment | University of Michigan Rogel Cancer Center

  https://www.rogelcancercenter.org/endocrine-cancer/pancreatic-neuroendocrine-tumors

  Pancreatic neuroendocrine tumors (pancreatic NETs or PNETs) account for less than 5% of all pancreatic tumors. […] The rarity of these tumors makes the care of these patients challenging and a multidisciplinary approach by experts in the field is important for patients to obtain the best care and treatment possible. […] The treatment of pancreatic neuroendocrine tumors requires a multidisciplinary approach with medical, surgical, oncologic and radiological treatments. Medical management is often used to control symptoms caused by tumor hormone production until surgical resection is undertaken. […] The Multidisciplinary Endocrine Tumor Program at the University of Michigan is composed of endocrinologists, endocrine surgeons, radiologists, nuclear medicine specialists and oncologists who specialize in all aspects of diagnosis and treatment of pancreatic endocrine tumors.

• #16 Neuroendocrine Tumors – Pancreatic Cancer  |  Johns Hopkins Pathology

  https://pathology.jhu.edu/pancreas/neuroendocrine

  The multidisciplinary team at Johns Hopkins is dedicated to providing the best cutting-edge care to our patients with neuroendocrine tumors of the pancreas. […] Our team includes highly-experienced surgeons, radiologists, interventional radiologists, pathologists, medical oncologists, radiation oncologists, gastroenterologists and geneticists is supported by a dedicated team of nurses, nurse practitioners and physician assistants. […] Most importantly, we care about, and are dedicated to, our patients. […] The management of patients with a neuroendocrine tumor therefore includes a good understanding of the role that family cancer history can play in these diseases. […] Neuroendocrine tumors are treated in very specific ways. Because some neuroendocrine tumors grow slowly, many neuroendocrine tumors are treated surgically. Other therapies specifically target unique receptors made by neuroendocrine tumors.

• #17 Pancreatic neuroendocrine tumors – Care at Mayo Clinic – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/pancreatic-neuroendocrine-tumors/care-at-mayo-clinic/mac-20352492

  The range of treatments offered to people with pancreatic neuroendocrine tumors includes surgery, targeted therapy, chemotherapy, radiofrequency ablation and peptide receptor radionuclide therapy (PRRT). […] People who seek care at Mayo Clinic have access to the latest treatments, including PRRT with lutetium Lu 177 dotatate (Lutathera). […] At Mayo Clinic, a multidisciplinary group of experts forms a team to care for people with pancreatic neuroendocrine tumors. […] More than 600 people with pancreatic neuroendocrine tumors receive care at Mayo Clinic each year. […] Mayo Clinic’s campuses in Florida and Minnesota are designated by the National Pancreas Foundation (NPF) as approved NPF Centers a recognition for high-quality, multidisciplinary care.

• #18 Treating Pancreatic Neuroendocrine Tumors | American Cancer Society

  https://www.cancer.org/cancer/types/pancreatic-neuroendocrine-tumor/treating.html

  For pancreatic neuroendocrine tumors (NETs), treatment options might include surgery, ablation or embolization treatments, radiation therapy, or different types of medicines. […] Many other specialists may be involved in your care as well, including nurse practitioners, nurses, psychologists, social workers, rehabilitation specialists, and other health professionals. […] Its important to discuss all of your treatment options, including their goals and possible side effects, with your doctors to help make the decision that best fits your needs. […] Be sure to talk to your cancer care team about any method you are thinking about using. They can help you learn what is known (or not known) about the method, which can help you make an informed decision. […] People with cancer need support and information, no matter what stage of illness they may be in. Knowing all of your options and finding the resources you need will help you make informed decisions about your care.

• #19 Pancreatic NET Treatment – San Diego – Scripps Health

  https://www.scripps.org/services/cancer-care/pancreatic-neuroendocrine-tumor-treatment

  Ablation treats pancreatic NETs by destroying them using cold, heat or other methods. […] Chemotherapy drugs can be used alone or in combination with other treatments to slow the growth of pancreatic neuroendocrine tumors. […] Hormone therapy may be part of a treatment plan to remove or block hormones and stop cancer cells from growing. […] We are here for you not only as your oncologists, but as a robust multidisciplinary team of experts who understands that your cancer journey is about much more than your medical treatment. […] Specifically, Scripps Cancer Center offers a variety of patient support services to ensure your physical, psychological and emotional well-being as well as resources for dealing with the logistical and financial aspects of cancer care. […] Oncology nurses and nurse navigators with extensive clinical expertise in cancer care to help guide you and your caregivers to make informed decisions and ensure your optimal care.

• #20 Neuroendocrine Tumors | Hoag Family Cancer Institute

  https://www.hoag.org/specialties-services/cancer/conditions/neuroendocrine-tumors/

  Hoag’s Neuroendocrine Tumor Program provides academic level care from a multidisciplinary, specialized team experienced in the accurate diagnosis and treatment of neuroendocrine tumors. […] Neuroendocrine tumors can be benign or malignant. Whether benign or malignant, it is recommended to have all abdominal NETs surgically removed. At the time of resection/following surgery, the distinction of a benign or malignant tumor will be determined. […] If neuroendocrine tumors are suspected, its important to seek proper evaluation and treatment from a healthcare expert experienced in the diagnosis and treatment of gastrointestinal issues. […] A clinical nurse navigator serves an important role as facilitator and guide for patients, providing resources, access to clinical providers and answering questions throughout the cancer journey.

• #21 Pancreatic neuroendocrine tumors – Diagnosis and treatment – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/pancreatic-neuroendocrine-tumors/diagnosis-treatment/drc-20475299

  Our caring team of Mayo Clinic experts can help you with your pancreatic neuroendocrine tumors-related health concerns […] Treatment for a pancreatic neuroendocrine tumor depends on the types of cells involved in your cancer, the extent and characteristics of your cancer, your preferences, and your overall health. […] Make an appointment with a health care professional if you have any symptoms that worry you. If you’re diagnosed with cancer, you’ll likely be referred to a specialist. Often this is a doctor who specializes in treating cancer, called an oncologist. […] When you make the appointment, ask if there’s anything you need to do in advance, such as fasting before having a specific test. […] Gather the medical records that relate to your condition and bring them to your appointment. If you’re seeing a new health care team, ask that any files and other information, such as glass slides that contain tissue samples, are sent to your new team.

• #22 Pancreatic Neuroendocrine Tumors – PNETs | Choose the Right Test

  https://arupconsult.com/content/pancreatic-neuroendocrine-tumors

  Pancreatic neuroendocrine tumors (PNETs) are rare tumors of pancreatic islet cells that account for approximately 10% of pancreatic tumors by prevalence. […] Laboratory testing for PNETs involves evaluation of specific biochemical markers, as determined by the clinical presentation. […] Genetic testing should be considered in all patients with PNETs. […] Monitoring should include biochemical marker testing, particularly if a functional syndrome was diagnosed. […] Once a PNET diagnosis has been established, patients should be monitored for the development of other conditions associated with MEN1.

• #23

  http://www.bccancer.bc.ca/books/neuroendocrine-tumors/pancreatic-neuroendocrine-tumors

  CT scan of the chest and abdomen/pelvis is recommended to assess the extent of local involvement and to exclude distant metastases. A pancreas-protocol CT scan or MRI is indicated if the patient is thought to be an operative candidate. If a mass is not clearly identified or if there is uncertainty regarding vascular involvement, an EUS should be performed. If there appears to be an isolated pancreatic lesion, refer to a hepatobiliary surgeon who will determine if the disease is resectable or unresectable. A biopsy is not always required but may be performed if clinically indicated. If there are obvious metastases, then the pancreatic mass or metastases can be biopsied percutaneously with ultrasound CT guidance or by endoscopic with fine needle aspiration. In patients who have carcinoid syndrome, a potential carcinoid crisis should be prevented by prophylactic administration of octreotide, given by constant intravenous infusion at a dose of 50 mcg/h for 12 hours prior to and at least 48 hours after the procedure.

• #24

  http://www.bccancer.bc.ca/books/neuroendocrine-tumors/pancreatic-neuroendocrine-tumors

  CT scan of the chest and abdomen/pelvis is recommended to assess the extent of local involvement and to exclude distant metastases. A pancreas-protocol CT scan or MRI is indicated if the patient is thought to be an operative candidate. If a mass is not clearly identified or if there is uncertainty regarding vascular involvement, an EUS should be performed. If there appears to be an isolated pancreatic lesion, refer to a hepatobiliary surgeon who will determine if the disease is resectable or unresectable. A biopsy is not always required but may be performed if clinically indicated. If there are obvious metastases, then the pancreatic mass or metastases can be biopsied percutaneously with ultrasound CT guidance or by endoscopic with fine needle aspiration. In patients who have carcinoid syndrome, a potential carcinoid crisis should be prevented by prophylactic administration of octreotide, given by constant intravenous infusion at a dose of 50 mcg/h for 12 hours prior to and at least 48 hours after the procedure.

• #25 Neuroendocrine Tumors – Brigham and Women’s Hospital

  https://www.brighamandwomens.org/surgery/general-and-gastrointestinal-surgery/services/neuroendocrine-tumors

  Our board certified surgeons perform a large volume of minimally invasive approaches, such as laparoscopic and robotic surgery, to surgically remove neuroendocrine tumors. […] Our surgeons offer extensive expertise in the most advanced minimally invasive surgical procedures for neuroendocrine tumors. When neuroendocrine tumors are detected at an early stage, they can usually be removed surgically. In most cases, post-surgical treatment with chemotherapy or radiation therapy is not necessary, and patients can be monitored with blood tests and scans. […] The day of surgery, you will be cared for in the operating room by surgeons, anesthesiologists and nurses who specialize in neuroendocrine tumor surgery. After surgery, you will recover in the post-surgical care unit where you will receive comprehensive care by an experienced surgical and nursing staff.

• #26

  http://www.bccancer.bc.ca/books/neuroendocrine-tumors/pancreatic-neuroendocrine-tumors

  Surgical treatment of pancreatic cancer should be undertaken by surgeons having expertise and experience with these tumours. For resectable pNETs: definitive resection of the primary tumour should always be performed whenever technically feasible. In patients who have carcinoid syndrome, a potential carcinoid crisis should be prevented by prophylactic administration of octreotide, given by constant intravenous infusion at a dose of 50 mcg/h for 12 hours prior to and at least 48 hours after the procedure. Prophylactic cholecystectomy should be considered during any surgery for neuroendocrine tumours. For localized, locoregional, or resectable metastatic pNETs, curative surgery should be considered if technically and clinically feasible. For unresectable metastatic pNETs, cytoreductive surgery to achieve maximal debulking and palliation of symptoms should be considered if technically feasible and clinically appropriate.

• #27 Neuroendocrine Tumors – Brigham and Women’s Hospital

  https://www.brighamandwomens.org/surgery/general-and-gastrointestinal-surgery/services/neuroendocrine-tumors

  Our board certified surgeons perform a large volume of minimally invasive approaches, such as laparoscopic and robotic surgery, to surgically remove neuroendocrine tumors. […] Our surgeons offer extensive expertise in the most advanced minimally invasive surgical procedures for neuroendocrine tumors. When neuroendocrine tumors are detected at an early stage, they can usually be removed surgically. In most cases, post-surgical treatment with chemotherapy or radiation therapy is not necessary, and patients can be monitored with blood tests and scans. […] The day of surgery, you will be cared for in the operating room by surgeons, anesthesiologists and nurses who specialize in neuroendocrine tumor surgery. After surgery, you will recover in the post-surgical care unit where you will receive comprehensive care by an experienced surgical and nursing staff.

• #28 Surgical Management of Pancreatic Neuroendocrine Tumors

  https://www.mdpi.com/2072-6694/15/7/2006

  Surgery is the main modality to achieve locoregional control for well-differentiated low-grade PNET, and the only potential cure for PNETs. Median overall survival is improved with resection for all low-grade PNETs, regardless of functional status. The role of surgical resection in localized high-grade well-differentiated PNETs is more limited, given their much more aggressive behavior, with surgery not indicated for poorly differentiated lesions. Despite differences in presentation, surgical approaches to functional and nonfunctional tumors are generally similar, generally consisting of partial pancreatectomy via traditional open or minimally invasive approaches. Operative approaches includes both open and minimally invasive techniques. Compared to traditional open approaches, laparoscopic distal pancreatectomy has been associated with a reduction in postoperative morbidity, with similar oncologic and survival outcomes. Prospective data also supports the use of minimally invasive surgery when possible, particularly for distal pancreatic tumors. Particular considerations for various PNETs are discussed below, with attention to specific issues with different functional PNETs, increased use of nonoperative therapy for small nonfunctional PNETs, the role of lymphadenectomy, the role of pancreas-sparing enucleation, and the role of metastasectomy.

• #29 Neuroendocrine Tumors (NETs): Symptoms & Treatment

  https://my.clevelandclinic.org/health/diseases/22006-neuroendocrine-tumors-net

  Many people diagnosed with a neuroendocrine tumor (NET) spend years trying to find out why they don’t feel well. Finally learning the cause and getting a diagnosis can, in a way, be a relief. That being said, knowing you have a serious uncommon illness might replace one set of uncertainties with another. Talking to your healthcare provider about your NET diagnosis and treatment plan can help you feel more certain and in control of your health.

• #30 Pancreatic Cancer: Nursing Diagnoses, Care Plans, Assessment & Interventions | NurseTogether

  https://www.nursetogether.com/pancreatic-cancer-nursing-diagnosis-care-plan/

  A dietitian is vital in planning nutritional interventions for patients with pancreatic cancer and those currently undergoing chemotherapy or radiation therapy. […] Emotional and spiritual comfort is vital in alleviating fear and anxiety. Offer time for listening so the patient can express their thoughts. […] Nursing care plans help prioritize assessments and interventions for both short and long-term goals of care.

• #31 Pancreatic neuroendocrine tumors – Diagnosis and treatment – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/pancreatic-neuroendocrine-tumors/diagnosis-treatment/drc-20475299

  Consider bringing a family member or friend to help you remember the information you’re given. […] Ask your health care team about support groups in your area. Other sources of information include the National Cancer Institute, the American Cancer Society, the North American Neuroendocrine Tumor Society and the Neuroendocrine Tumor Research Foundation.

• #32 Neuroendocrine Tumors Guidelines: Initial Evaluation, Grading and Staging, Gastrointestinal and Pulmonary Carcinoid Tumors

  https://emedicine.medscape.com/article/2500010-overview

  For nonfunctioning pancreatic NETs, treatment recommendations are as follows: Tumors 2 cm: Enucleation of the tumors with strong consideration of lymph node resection or pancreatectomy (Whipple type or proximal) with or without regional node resection, or distal pancreatectomy with or without regional node resection/splenectomy. […] The North American Neuroendocrine Tumor Society (NANETS) guidelines, European Neuroendocrine Tumor Society (ENETS) guidelines, and the European Society for Medical Oncology (ESMO) guidelines for treatment of neuroendocrine pancreatic tumors are similar to those of the NCCN, with some minor variances. […] NCCN recommendations for the treatment of unresectable and/or metastatic pancreatic tumors include the following: Limited hepatic metastases: Complete resection of primary tumor and metastases with curative intent; noncurative cytoreduction surgery in select cases. […] Symptomatic unresectable disease: Octreotide or lanreotide; everolimus or sunitinib; or cytotoxic chemotherapy. […] Liver transplantation is investigational and not recommended as routine care.

• #33

  http://www.bccancer.bc.ca/books/neuroendocrine-tumors/pancreatic-neuroendocrine-tumors

  Treatment options are based on current evidence. Surgery is the only curative treatment. Indications for surgery depend upon the size and location of the pNET. Surgical procedures include: pancreaticoduodenectomy (Whipples resection: classic or pylorus-preserving), distal pancreatectomy +/- splenectomy, tumour enucleation, enucleation combined with resection, regional lymph node dissection required for 'malignant’ (high grade) pNETs. Patients with limited metastatic disease should be considered for surgery. […] Adjuvant – there is no established adjuvant therapy for patients with completely resected pancreatic NET. The following systemic regimens are approved for BC Cancer funding in advanced pancreatic (GI/Lung) NET disease refer to the specified protocols in the Chemotherapy Protocols section for details on eligibility and indications. Octreotide is the primary treatment for patients with symptomatic functioning pancreatic NET. About 80-90% of patients experience prompt improvement of their symptoms. Caution should be taken with the use of octreotide in patients with insulinomas, since concomitant suppression of GH and glucagon can lead to a worsening of hyperglycemia. A significant tumour regression may be observed in 10% of patients, but stabilization of tumour growth may occur in 30-50% of patients. After a period of control, some patients may experience recurrence of their symptoms. The dose of octreotide should be increased or the interval between treatments reduced. […] Symptom management (including celiac or intrapleural block for tumour-related pain), pancreatic enzyme replacement for diarrhea, best supportive care, and involvement of palliative care services as indicated by patients clinical status.

• #34

  http://www.bccancer.bc.ca/books/neuroendocrine-tumors/pancreatic-neuroendocrine-tumors

  Treatment options are based on current evidence. Surgery is the only curative treatment. Indications for surgery depend upon the size and location of the pNET. Surgical procedures include: pancreaticoduodenectomy (Whipples resection: classic or pylorus-preserving), distal pancreatectomy +/- splenectomy, tumour enucleation, enucleation combined with resection, regional lymph node dissection required for 'malignant’ (high grade) pNETs. Patients with limited metastatic disease should be considered for surgery. […] Adjuvant – there is no established adjuvant therapy for patients with completely resected pancreatic NET. The following systemic regimens are approved for BC Cancer funding in advanced pancreatic (GI/Lung) NET disease refer to the specified protocols in the Chemotherapy Protocols section for details on eligibility and indications. Octreotide is the primary treatment for patients with symptomatic functioning pancreatic NET. About 80-90% of patients experience prompt improvement of their symptoms. Caution should be taken with the use of octreotide in patients with insulinomas, since concomitant suppression of GH and glucagon can lead to a worsening of hyperglycemia. A significant tumour regression may be observed in 10% of patients, but stabilization of tumour growth may occur in 30-50% of patients. After a period of control, some patients may experience recurrence of their symptoms. The dose of octreotide should be increased or the interval between treatments reduced. […] Symptom management (including celiac or intrapleural block for tumour-related pain), pancreatic enzyme replacement for diarrhea, best supportive care, and involvement of palliative care services as indicated by patients clinical status.

• #35 FAQ About Neuroendocrine and Carcinoid Tumors | Dana-Farber Cancer Institute

  https://www.dana-farber.org/cancer-care/treatment/gastrointestinal/programs/neuroendocrine-carcinoid/faq

  Chemotherapy has been used for many years as a treatment for neuroendocrine tumors, and in some cases can be highly effective, particularly for pancreatic neuroendocrine tumors. Drugs that are used include streptozocin and temozolomide. […] In 2011, two targeted therapies were approved for use for pancreatic neuroendocrine tumors: Sunitinib targets angiogenesis (the process by which tumors grow new blood vessels). Everolimus targets a molecule called mTOR, which serves as a central signaling molecule for a number of cancer growth pathways. Everolimus was also approved in 2016 for the treatment of lung and gastrointestinal neuroendocrine tumors.

• #36 Pancreatic neuroendocrine tumors – Care at Mayo Clinic – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/pancreatic-neuroendocrine-tumors/care-at-mayo-clinic/mac-20352492

  The range of treatments offered to people with pancreatic neuroendocrine tumors includes surgery, targeted therapy, chemotherapy, radiofrequency ablation and peptide receptor radionuclide therapy (PRRT). […] People who seek care at Mayo Clinic have access to the latest treatments, including PRRT with lutetium Lu 177 dotatate (Lutathera). […] At Mayo Clinic, a multidisciplinary group of experts forms a team to care for people with pancreatic neuroendocrine tumors. […] More than 600 people with pancreatic neuroendocrine tumors receive care at Mayo Clinic each year. […] Mayo Clinic’s campuses in Florida and Minnesota are designated by the National Pancreas Foundation (NPF) as approved NPF Centers a recognition for high-quality, multidisciplinary care.

• #37 Pancreatic Neuroendocrine Tumors | Center for Advanced Digestive Care – NewYork-Presbyterian/Weill Cornell Medical Center

  https://www.nyp.org/cadc/neuroendocrine-tumors/pancreatic-neuroendocrine-tumors

  Hormone therapy may be given to help stop the tumor from growing, or to relieve symptoms caused by the tumor by lowering the levels of hormones in the body. […] Systemic chemotherapy, delivered through the bloodstream, employs drugs to kill cancer cells. Chemotherapy may be used to treat advanced neuroendocrine tumors that contain fast-growing cells. […] Some patients with neuroendocrine tumors benefit from radiation therapy, which uses a type of energy called ionizing radiation to kill cancer cells and shrink tumors. The goal is to kill as many cancer cells as possible without harming healthy tissue. […] Most pancreatic tumors contain receptors for the hormone somatostatin. These tumors may therefore respond to a nuclear medicine technique called radiolabeled therapy, which selectively destroys tumor cells with radioactivity attached to a molecule that binds to somatostatin receptors.

• #38 Shedding light on pancreatic neuroendocrine tumors – UChicago Medicine

  https://www.uchicagomedicine.org/forefront/cancer-articles/shedding-light-on-pancreatic-neuroendocrine-tumors

  In addition to or instead of surgery, some patients received intramuscular injections or a daily oral pill to slow down the tumor growth, which sometimes is successful for many years. […] PRRT is a radioactive infusion given every other month for eight months that targets the tumor cells without having to affect other organs. […] These tumors grow slowly over months and years without ever being noticed. […] If the tumors do secrete hormones such as insulin or gastrin, they are typically diagnosed more quickly. […] We are studying how to improve the effectiveness of PRRT to make it better for pancreatic and other NET patients.

• #39 FAQ About Neuroendocrine and Carcinoid Tumors | Dana-Farber Cancer Institute

  https://www.dana-farber.org/cancer-care/treatment/gastrointestinal/programs/neuroendocrine-carcinoid/faq

  Chemotherapy has been used for many years as a treatment for neuroendocrine tumors, and in some cases can be highly effective, particularly for pancreatic neuroendocrine tumors. Drugs that are used include streptozocin and temozolomide. […] In 2011, two targeted therapies were approved for use for pancreatic neuroendocrine tumors: Sunitinib targets angiogenesis (the process by which tumors grow new blood vessels). Everolimus targets a molecule called mTOR, which serves as a central signaling molecule for a number of cancer growth pathways. Everolimus was also approved in 2016 for the treatment of lung and gastrointestinal neuroendocrine tumors.

• #40 Neuroendocrine Tumors (NETs): Symptoms & Treatment

  https://my.clevelandclinic.org/health/diseases/22006-neuroendocrine-tumors-net

  Surgery is the most common treatment for a NET. If your tumors are large or have spread, other treatments you might need include: […] Somatostatin analogs are medications that prevent your body from making excess hormones. They can reduce symptoms of functional NETs and slow tumor growth. […] Neuroendocrine tumors and their treatment can take a toll on your body. You may have to manage common symptoms like fatigue feeling extremely tired day after day and diarrhea throughout your treatment. Try to get as much rest as you can. If diarrhea is an issue, talk to your healthcare provider about ways to reduce its frequency and severity. […] Contact your healthcare provider if you have a NET and are noticing changes in your body that may be signs of carcinoid syndrome, like flushing, diarrhea or wheezing. You should also contact your provider if your symptoms become worse or if you’re experiencing treatment side effects.

• #41 Pancreatic Neuroendocrine Tumors – Information – OHC

  https://ohcare.com/condition/pancreatic-neuroendocrine-tumors/

  Supportive care is given to lessen the problems caused by the disease or its treatment. Supportive care for pancreatic NETs may include treatment for the following: […] Stomach ulcers may be treated with drug therapy such as proton pump inhibitor drugs such as omeprazole, lansoprazole, or pantoprazole; histamine blocking drugs such as cimetidine, ranitidine, or famotidine; or somatostatin-type drugs such as octreotide. […] Diarrhea may be treated with intravenous (IV) fluids with electrolytes such as potassium or chloride or somatostatin-type drugs such as octreotide. […] Low blood sugar may be treated by having small, frequent meals or with drug therapy to maintain a normal blood sugar level. […] High blood sugar may be treated with drugs taken by mouth or insulin by injection.

• #42 Pancreas – Neuroendocrine Cancer UK

  https://www.neuroendocrinecancer.org.uk/neuroendocrine-cancer/neuroendocrine-cancer-by-primary-secondary-sites/pancreas/

  Welcome to our dedicated webpage focusing on pancreatic neuroendocrine cancer. Here, we aim to provide you with a comprehensive understanding of this complex disease. Delve into our comprehensive guide, for information about different types of pancreatic neuroendocrine neoplasms, insights into symptoms, diagnostic tests, treatment, and grading. Follow-up, and factors contributing to the development of pancreatic neuroendocrine cancer. […] Pancreatic Exocrine Insufficiency (PEI) can lead to malnutrition due to nutrient malabsorption, underlying pancreatic disease effects, and symptom impact on oral intake. Symptoms include steatorrhea (pale, fatty/greasy, loose stools), weight loss, diarrhoea, abdominal pain, and bloating. […] Pancreatic Enzyme Replacement Therapy (PERT) is the primary treatment and significantly improves survival and quality of life (QoL) in PEI patients. […] Pancreatic enzyme replacement therapy (PERT) is the cornerstone of treatment and is associated with improved survival and quality of life (QoL) in patients with PEI.

• #43

  http://www.bccancer.bc.ca/books/neuroendocrine-tumors/pancreatic-neuroendocrine-tumors

  Treatment options are based on current evidence. Surgery is the only curative treatment. Indications for surgery depend upon the size and location of the pNET. Surgical procedures include: pancreaticoduodenectomy (Whipples resection: classic or pylorus-preserving), distal pancreatectomy +/- splenectomy, tumour enucleation, enucleation combined with resection, regional lymph node dissection required for 'malignant’ (high grade) pNETs. Patients with limited metastatic disease should be considered for surgery. […] Adjuvant – there is no established adjuvant therapy for patients with completely resected pancreatic NET. The following systemic regimens are approved for BC Cancer funding in advanced pancreatic (GI/Lung) NET disease refer to the specified protocols in the Chemotherapy Protocols section for details on eligibility and indications. Octreotide is the primary treatment for patients with symptomatic functioning pancreatic NET. About 80-90% of patients experience prompt improvement of their symptoms. Caution should be taken with the use of octreotide in patients with insulinomas, since concomitant suppression of GH and glucagon can lead to a worsening of hyperglycemia. A significant tumour regression may be observed in 10% of patients, but stabilization of tumour growth may occur in 30-50% of patients. After a period of control, some patients may experience recurrence of their symptoms. The dose of octreotide should be increased or the interval between treatments reduced. […] Symptom management (including celiac or intrapleural block for tumour-related pain), pancreatic enzyme replacement for diarrhea, best supportive care, and involvement of palliative care services as indicated by patients clinical status.

• #44 Pancreatic Cancer: Nursing Diagnoses, Care Plans, Assessment & Interventions | NurseTogether

  https://www.nursetogether.com/pancreatic-cancer-nursing-diagnosis-care-plan/

  Nurses provide symptomatic and supportive care to patients diagnosed with pancreatic cancer with interventions like administering medications, providing comfort measures, offering psychological support, ensuring adequate nutrition, and providing patient education and resources. […] Nursing interventions and care are essential for the patients recovery. In the following section, you’ll learn more about possible nursing interventions for a patient with pancreatic cancer. […] Palliative care is not curative and focuses on managing symptoms and pain for improved quality of life. This can be achieved through surgical procedures, nutritional support, chemotherapy, and more. […] Patients with pancreatic carcinoma frequently exhibit weight loss due to anorexia (loss of appetite), as do most patients with advanced malignancy.

• #45 Pancreatic Cancer: Nursing Diagnoses, Care Plans, Assessment & Interventions | NurseTogether

  https://www.nursetogether.com/pancreatic-cancer-nursing-diagnosis-care-plan/

  A dietitian is vital in planning nutritional interventions for patients with pancreatic cancer and those currently undergoing chemotherapy or radiation therapy. […] Emotional and spiritual comfort is vital in alleviating fear and anxiety. Offer time for listening so the patient can express their thoughts. […] Nursing care plans help prioritize assessments and interventions for both short and long-term goals of care.

• #46 Pancreatic NET Treatment – San Diego – Scripps Health

  https://www.scripps.org/services/cancer-care/pancreatic-neuroendocrine-tumor-treatment

  Palliative care to provide an extra layer of supportive care to manage pain and relieve symptoms, offer emotional and spiritual support, and improve your quality of life. […] Our registered dietitian nutritionists offer individualized nutrition support for patients whose efforts to optimize their nutrition may be affected by cancer symptoms or treatment side effects.

• #47 Pancreatic NET Treatment – San Diego – Scripps Health

  https://www.scripps.org/services/cancer-care/pancreatic-neuroendocrine-tumor-treatment

  Palliative care to provide an extra layer of supportive care to manage pain and relieve symptoms, offer emotional and spiritual support, and improve your quality of life. […] Our registered dietitian nutritionists offer individualized nutrition support for patients whose efforts to optimize their nutrition may be affected by cancer symptoms or treatment side effects.

• #48 Treating Pancreatic Neuroendocrine Tumors | American Cancer Society

  https://www.cancer.org/cancer/types/pancreatic-neuroendocrine-tumor/treating.html

  Different types of programs and support services may be helpful, and they can be an important part of your care. These might include nursing or social work services, financial aid, nutritional advice, rehab, or spiritual help. […] Remember that even if you choose not to treat the cancer, you can still get supportive care to help with pain or other symptoms. […] Nursing care and special equipment can make staying at home a workable option for many families.

• #49 Pancreatic Neuroendocrine Tumour Treatments

  https://neuroendocrine.org.au/treatments/treatment-for-pancreatic-neuroendocrine-tumours/

  PRRT has shown efficacy in controlling tumour growth, improving symptom control, and prolonging progression-free survival in patients with advanced PNETs. […] In cases of advanced PNETs where treatment options are limited, palliative care plays a critical role in enhancing patients quality of life and providing symptom relief. […] Managing symptoms such as pain and hormonal imbalances is central to palliative care in PNETs. […] Regular follow-up appointments, including imaging studies (such as PET scans, CT scans or MRIs) and blood and urine tests, enable healthcare providers to assess disease status and intervene promptly if necessary. […] The management of pancreatic neuroendocrine tumours requires a multifaceted approach encompassing radiotherapy, multimodal treatment strategies, palliative care, and vigilant follow-up care.

• #50 Living as a Pancreatic Neuroendocrine Tumor Survivor | American Cancer Society

  https://www.cancer.org/cancer/types/pancreatic-neuroendocrine-tumor/after-treatment/follow-up.html

  For some people with a pancreatic neuroendocrine tumor (pNET), treatment can remove or destroy the cancer. […] It is very important to go to all your follow-up appointments. During these visits, your doctors will ask if you are having any problems, examine you, and, if needed, order lab tests or x-rays and scans to look for signs of cancer or treatment side effects. […] Your schedule of doctor visits, exams, and tests will depend on the original extent of your cancer, the specific type of pNET you had, how it was treated, and other factors. […] Talk with your doctor about developing a survivorship care plan for you. […] Even after treatment, its very important to keep health insurance. […] If you have (or have had) pancreatic NET, you probably want to know if there are things you can do that might lower the risk of the cancer growing or coming back, such as exercising, eating a certain type of diet, or taking nutritional supplements. […] Many people with a pancreatic NET are treated with medicines that keep the disease in check without curing the disease, so they need to see their doctors regularly. […] It is normal to feel depressed, anxious, or worried when pNET is a part of your life.

• #51 Living as a Pancreatic Neuroendocrine Tumor Survivor | American Cancer Society

  https://www.cancer.org/cancer/types/pancreatic-neuroendocrine-tumor/after-treatment/follow-up.html

  For some people with a pancreatic neuroendocrine tumor (pNET), treatment can remove or destroy the cancer. […] It is very important to go to all your follow-up appointments. During these visits, your doctors will ask if you are having any problems, examine you, and, if needed, order lab tests or x-rays and scans to look for signs of cancer or treatment side effects. […] Your schedule of doctor visits, exams, and tests will depend on the original extent of your cancer, the specific type of pNET you had, how it was treated, and other factors. […] Talk with your doctor about developing a survivorship care plan for you. […] Even after treatment, its very important to keep health insurance. […] If you have (or have had) pancreatic NET, you probably want to know if there are things you can do that might lower the risk of the cancer growing or coming back, such as exercising, eating a certain type of diet, or taking nutritional supplements. […] Many people with a pancreatic NET are treated with medicines that keep the disease in check without curing the disease, so they need to see their doctors regularly. […] It is normal to feel depressed, anxious, or worried when pNET is a part of your life.

• #52 Pancreatic Neuroendocrine Tumour Treatments

  https://neuroendocrine.org.au/treatments/treatment-for-pancreatic-neuroendocrine-tumours/

  PRRT has shown efficacy in controlling tumour growth, improving symptom control, and prolonging progression-free survival in patients with advanced PNETs. […] In cases of advanced PNETs where treatment options are limited, palliative care plays a critical role in enhancing patients quality of life and providing symptom relief. […] Managing symptoms such as pain and hormonal imbalances is central to palliative care in PNETs. […] Regular follow-up appointments, including imaging studies (such as PET scans, CT scans or MRIs) and blood and urine tests, enable healthcare providers to assess disease status and intervene promptly if necessary. […] The management of pancreatic neuroendocrine tumours requires a multifaceted approach encompassing radiotherapy, multimodal treatment strategies, palliative care, and vigilant follow-up care.

• #53 Pancreatic neuroendocrine cancers (PancNETs) – Pancreatic Cancer UK

  https://www.pancreaticcancer.org.uk/information/just-diagnosed-with-pancreatic-cancer/pancreatic-neuroendocrine-tumours-pancnets/

  Speak to your medical team with any questions about pancreatic neuroendocrine cancers and how they are treated. […] Neuroendocrine Cancer UK have more detailed information and support around diagnosing, treating, managing and living with pancreatic neuroendocrine cancer. They have a helpline with a specialist nurse, online and local support groups, an online community and a dedicated neuroendocrine cancer counselling team. […] Questions to ask your doctor or nurse include: What type of pancreatic neuroendocrine cancer do I have? Is it a neuroendocrine tumour or a neuroendocrine carcinoma? Is it functioning or non-functioning? How is this type of neuroendocrine cancer treated?

• #54 Pancreatic Neuroendocrine Tumor

  https://spartanburgregional.staywellsolutionsonline.com/Library/Wellness/Parenting/134,40

  Talk with your healthcare providers about your treatment options. Make a list of questions. Think about the benefits and possible side effects of each option. Talk about your concerns with your healthcare provider before making a decision. […] Call your healthcare provider if you have: […] Many of these symptoms may be caused by other health problems. Still, it’s important to see your healthcare provider if you have these symptoms. Only a healthcare provider can tell if you have a tumor or cancer. […] Blood tests and imaging scans can help diagnose these tumors. […] Surgery is the main treatment. […] Your treatment choices depend on the type of pancreatic NET you have, test results, if the tumor is cancer, and the stage of the cancer. The goal of treatment may be to cure you, control the tumor or cancer, or to help ease problems caused by the tumor or cancer.

• #55 Pancreatic Neuroendocrine Tumor

  https://healthlibrary.osfhealthcare.org/Conditions/Cancer/134,40

  Your healthcare provider uses medicines to help manage your symptoms from the pancreatic NET. These may include: […] Talk with your healthcare providers about your treatment options. Make a list of questions. Think about the benefits and possible side effects of each option. Talk about your concerns with your healthcare provider before making a decision. […] Call your healthcare provider if you have:

• #56 Pancreatic Neuroendocrine Tumors: Symptoms & Treatment

  https://my.clevelandclinic.org/health/diseases/21970-pancreatic-neuroendocrine-tumors

  Pancreatic neuroendocrine tumors develop in the endocrine cells in your pancreas. Treatment is surgery to remove the tumors or receptor-targeted therapies and other nonsurgical treatments. […] Treatment for early-stage pancreatic NET is a pancreatectomy to remove the tumor. This is a treatment for cancerous and noncancerous tumors. Specific surgeries vary depending on the tumors location in your pancreas. […] Surgery may not be an option if you have an advanced form of pancreatic NET. Your oncologist may recommend other treatments, including: Hormone therapy, Peptide receptor radionuclide therapy (PRRT), Tyrosine kinase inhibitors, Chemotherapy. […] You should see your healthcare provider if you notice changes in your body, like your original symptoms worsening. These changes might be unrelated to your condition. The best way to be sure is to talk to your provider.

• #57 Neuroendocrine Tumors (NETs): Symptoms & Treatment

  https://my.clevelandclinic.org/health/diseases/22006-neuroendocrine-tumors-net

  Surgery is the most common treatment for a NET. If your tumors are large or have spread, other treatments you might need include: […] Somatostatin analogs are medications that prevent your body from making excess hormones. They can reduce symptoms of functional NETs and slow tumor growth. […] Neuroendocrine tumors and their treatment can take a toll on your body. You may have to manage common symptoms like fatigue feeling extremely tired day after day and diarrhea throughout your treatment. Try to get as much rest as you can. If diarrhea is an issue, talk to your healthcare provider about ways to reduce its frequency and severity. […] Contact your healthcare provider if you have a NET and are noticing changes in your body that may be signs of carcinoid syndrome, like flushing, diarrhea or wheezing. You should also contact your provider if your symptoms become worse or if you’re experiencing treatment side effects.

• #58 Neuroendocrine Tumor Care | Rush

  https://www.rush.edu/services/neuroendocrine-tumor-care

  Your care team will work with you to develop a comprehensive neuroendocrine tumor treatment plan based on up-to-date research and tailored to your needs. […] Because neuroendocrine tumors are rare and their treatment is complex, its important to make sure you have an expert team in your corner. […] When you come to Rush, your expert care team will go over all of your options for neuroendocrine tumor care and work closely with you to develop a comprehensive treatment plan. […] Your treatment may include peptide receptor radionuclide therapy (PRRT), an innovative treatment for metastatic neuroendocrine tumors that targets cancer cells in multiple places in the body without damaging healthy tissue. […] You may also be a candidate for genetic testing and analysis to help us better understand your tumor and find the best therapies.

• #59 Neuroendocrine Tumors (NETs) | Knight Cancer Institute | OHSU

  https://www.ohsu.edu/knight-cancer-institute/neuroendocrine-tumors-nets

  Neuroendocrine tumors (NETs) are a rare but complex type of cancer that can arise in many parts of the body. Because NETs are uncommon, its important to get care from doctors with expertise in this condition. […] The Knight Cancer Institute has a multidisciplinary team of experts who focus on NETs. […] Your team will include experts in surgery, medication, radiation, imaging, and more. […] Each patient, and each NET, is unique. Your team will talk with you and with one another to recommend a treatment plan. […] We treat patients with every stage of disease. If a cure is out of reach, treatment can give you the longest survival and best quality of life possible. […] Surgically removing NETs is usually the best first option. We use minimally invasive laparoscopic surgery (also known as keyhole surgery) when we can.

• #60 Update on pancreatic neuroendocrine tumors

  https://pmc.ncbi.nlm.nih.gov/articles/PMC4244504/

  Pancreatic neuroendocrine tumors (pNETs) are relatively rare tumors comprising 1-2% of all pancreas neoplasms. […] Management of these patients requires multidisciplinary care combining the best of surgery, chemotherapy and other targeted therapies. […] The goal of therapy in advanced disease is to palliate the symptoms of hormone excess in functional tumors and lengthen survival. This requires a multidisciplinary approach including cytoreductive surgery when appropriate, directed therapy for the treatment of liver metastases when possible, and systemic medical therapy. […] Local disease is treated with surgical removal of the tumor. Possible operations include simple enucleation, distal pancreatectomy with splenectomy, spleen-preserving distal pancreatectomy, central pancreatectomy, pancreaticoduodenectomy, and total pancreatectomy.

• #61 Pancreatic neuroendocrine tumors: A review of serum biomarkers, staging, and management

  https://www.wjgnet.com/1007-9327/full/v26/i19/2305.htm

  Pancreatic neuroendocrine tumors (pNETs) are a heterogeneous group of tumors with complicated treatment options that depend on pathological grading, clinical staging, and presence of symptoms related to hormonal secretion. […] Surgical resection is still the only curative therapeutic option for localized pNETs. However, a debulking operation has also been proven to be effective for controlling the disease. […] As for drug therapy, steroids and somatostatin analogues are the first-line therapy for those with positive expression of somatostatin receptor, while everolimus and sunitinib represent important progress for the treatment of patients with advanced pNETs. […] The optimal timing of local control intervention, planning of sequential therapies, and implementation of multidisciplinary care remain pending.

• #62 Update on pancreatic neuroendocrine tumors

  https://pmc.ncbi.nlm.nih.gov/articles/PMC4244504/

  Pancreatic neuroendocrine tumors (pNETs) are relatively rare tumors comprising 1-2% of all pancreas neoplasms. […] Management of these patients requires multidisciplinary care combining the best of surgery, chemotherapy and other targeted therapies. […] The goal of therapy in advanced disease is to palliate the symptoms of hormone excess in functional tumors and lengthen survival. This requires a multidisciplinary approach including cytoreductive surgery when appropriate, directed therapy for the treatment of liver metastases when possible, and systemic medical therapy. […] Local disease is treated with surgical removal of the tumor. Possible operations include simple enucleation, distal pancreatectomy with splenectomy, spleen-preserving distal pancreatectomy, central pancreatectomy, pancreaticoduodenectomy, and total pancreatectomy.

• #63 Pancreatic neuroendocrine tumors – Diagnosis and treatment – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/pancreatic-neuroendocrine-tumors/diagnosis-treatment/drc-20475299

  Consider bringing a family member or friend to help you remember the information you’re given. […] Ask your health care team about support groups in your area. Other sources of information include the National Cancer Institute, the American Cancer Society, the North American Neuroendocrine Tumor Society and the Neuroendocrine Tumor Research Foundation.

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