Materiały źródłowe

• #1 Frontotemporal dementia – Diagnosis and treatment – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/frontotemporal-dementia/diagnosis-treatment/drc-20354741

  There’s currently no cure or treatment for frontotemporal dementia, although research into treatments is ongoing. Medicines used to treat or slow Alzheimer’s disease don’t seem to be helpful for people with frontotemporal dementia. Some Alzheimer’s medicines may worsen the FTD symptoms. But certain medicines and speech therapy can help manage your symptoms. […] People with frontotemporal dementia who have trouble with language may benefit from speech therapy. Speech therapy teaches people to use communication aids.

• #2

  https://www.nhs.uk/conditions/frontotemporal-dementia/treatment/

  There’s currently no cure for frontotemporal dementia, but there are treatments that can help manage some of the symptoms. […] Medicines cannot stop frontotemporal dementia getting worse, but it can help reduce some of the symptoms for some people. […] The following medicines may help: antidepressants called selective serotonin reuptake inhibitors (SSRIs) may help control the loss of inhibitions, overeating and compulsive behaviours seen in some people. […] Antipsychotics these are rarely used, but are sometimes needed if SSRIs have not worked, as they can help control severely challenging behaviour that’s putting the person with dementia or others around them at risk of harm. […] In addition to medicines, there are a number of therapies and practical measures that can help make everyday living easier for someone with dementia.

• #3 Treatment of Frontotemporal Dementia

  https://pmc.ncbi.nlm.nih.gov/articles/PMC4920050/

  Frontotemporal dementia (FTD) encompasses a spectrum of neurodegenerative diseases with heterogeneous clinical presentations and two predominant types of underlying neuropathology. […] Currently there are no Food and Drug Administration (FDA) approved therapies for the above syndromes except riluzole for ALS. FTD treatment strategies generally rely on off-label use of medications for symptomatic management, and most therapies lack quality evidence from randomized, placebo-controlled clinical trials. […] For behavioral symptoms, selective serotonin reuptake inhibitors may be effective, while case reports hint at possible efficacy with antipsychotics or antiepileptics, but use of these latter agents is limited due to concerns regarding side effects. […] There are no effective therapies for cognitive complaints in FTD, which frequently involve executive function, memory, and language.

• #4 Treatment and support for frontotemporal dementia | Alzheimer’s Society

  https://www.alzheimers.org.uk/about-dementia/types-dementia/treatment-support-frontotemporal-dementia

  There is currently no cure for frontotemporal dementia (FTD) and its progression cannot be slowed down by medicines. […] The medicines commonly used to improve memory and thinking in other types of dementia are not recommended for people with FTD. They may even make symptoms worse. […] Some medicines and other therapies have been shown to help with some of the symptoms of FTD, although they won’t slow down the disease itself. […] Changes in mood and behaviour can sometimes be helped with medicines, such as those often prescribed for people with anxiety or depression. The most common medications used are citalopram and escitalopram. […] Antipsychotics are sometimes used for severe symptoms that put the person or others at risk of harm. These include hallucinations, delusions, or aggressive behaviour. However, they should only be used when all other solutions have been tried, and at the smallest possible dose for the shortest amount of time. This is because there is little evidence that they work for people with FTD and they may have potentially dangerous side effects.

• #5 Treatment of Frontotemporal Dementia

  https://pmc.ncbi.nlm.nih.gov/articles/PMC4920050/

  Physical and occupational therapy remain an important corner stone of motor symptom management in FTD. Speech therapy may also help patients manage symptoms associated with aphasia, apraxia, and dysarthria. […] Currently, the evidence suggests cholinesterase inhibitors are not effective treatments in FTD or PSP patients and may exacerbate behavioral or motor symptoms, respectively. […] These studies provide fairly strong evidence that memantine is not an effective treatment for FTD and illustrates the limitations of extrapolating efficacy of drugs for FTD based on other neurodegenerative disease, despite strong scientific rationale. […] It is generally believed that anti-depressants may help to manage various behavioral symptoms in FTD patients, but with most evidence coming from open-label trials or case series, the evidence to support this opinion is mainly anecdotal.

• #6

  https://www.nhs.uk/conditions/frontotemporal-dementia/treatment/

  There’s currently no cure for frontotemporal dementia, but there are treatments that can help manage some of the symptoms. […] Medicines cannot stop frontotemporal dementia getting worse, but it can help reduce some of the symptoms for some people. […] The following medicines may help: antidepressants called selective serotonin reuptake inhibitors (SSRIs) may help control the loss of inhibitions, overeating and compulsive behaviours seen in some people. […] Antipsychotics these are rarely used, but are sometimes needed if SSRIs have not worked, as they can help control severely challenging behaviour that’s putting the person with dementia or others around them at risk of harm. […] In addition to medicines, there are a number of therapies and practical measures that can help make everyday living easier for someone with dementia.

• #7 Treating FTD | AFTD

  https://www.theaftd.org/for-health-professionals/treating-ftd/

  A limited number of open-label studies and placebo controlled studies have researched the use of psychiatric, Alzheimer’s and other medications in FTD. While pharmacological intervention is expected to improve with advancing research, existing agents can be used to address symptoms and contribute to patient and caregiver quality of life. […] Selective serotonin reuptake inhibitors (SSRIs) are often useful treating a wide range of behavioral symptoms in FTD, including apathy, depression, agitation, anxiety, and obsessive-compulsive behaviors. These agents are considered relatively safe in the dementia population. […] Aggressive and agitated behavior can be difficult to treat, and are problematic for caregivers. Antipsychotic medications should be avoided when possible due to the increased mortality, stroke and cardiac complications of these medications in (elderly) dementia patients.

• #8 Frontotemporal dementia treatments – Alzheimer’s Research UK

  https://www.alzheimersresearchuk.org/dementia-information/types-of-dementia/frontotemporal-dementia/treatments/

  At the moment there are no drugs to treat the underlying disease in frontotemporal dementia. Some medications may help with some symptoms, for example low mood and problems sleeping. […] Currently, there are no medications available to treat frontotemporal dementia and to stop it from progressing. So, the focus of healthcare professionals is to help people with the disease manage their symptoms in everyday life. […] While drug treatments are limited, a group of antidepressant medications called SSRIs can sometimes help to manage behavioural symptoms in people with FTD. […] If someone with FTD is experiencing severe agitation or aggression, a doctor may first assess their general health and environment. This could help identify any causes or triggers of these symptoms. They may suggest complementary treatments such as aromatherapy or music therapy. These can be designed to draw on a person’s own interests and may help to relieve aggression and agitation. […] In rare cases, doctors may prescribe antipsychotic drugs to relieve severe symptoms. These drugs are not suitable for everyone so your doctor will carefully consider what is appropriate. They can have serious side-effects and their use should be carefully monitored.

• #9 Aripiprazole for the treatment of behavioral and psychiatric symptoms of frontotemporal dementia: a case report

  https://psychiatry-psychopharmacology.com/en/aripiprazole-for-the-treatment-of-behavioral-and-psychiatric-symptoms-of-frontotemporal-dementia-a-case-report-131238

  Frontotemporal dementia (FTD) is the second most common cause of early onset dementia and is clinically characterized by progressive behavioral change, executive dysfunctions, and language difficulties. […] FTD has not any specific treatment yet. Treatments for control of behavioral symptoms constitute majority of treatment approaches. […] The management of FTD, a disorder characterized by varied behavioral symptoms, primarily involves the use of psychoactive medications. […] Although there are no approved treatments for the disorder; selective serotonin receptor inhibitors such as sertraline, paroxetine, or uoxetine can decrease disinhibition-impulsivity, repetitive behaviors, and eating disorders in FTD. Low doses of trazodone or an atypical antipsychotic such as aripiprazole can also help manage significantly disturbed or agitated behavior. […] Case reports and open-label studies reported that aripiprazole, risperidone and olanzapine exert positive effects to control behavioral symptoms of FTD. […] We reported a patient with behavioral and psychiatric symptoms successfully treated with aripiprazole.

• #10

  https://link.springer.com/article/10.1007/s13670-021-00360-y

  The diagnosis and treatment of behavioral variant frontotemporal dementia is challenging and often delayed because of overlapping symptoms with more common dementia syndromes or primary psychiatric illnesses. […] Non-pharmacologic interventions and caregiver support are the cornerstone of treatment. The use of cholinesterase inhibitors and memantine is not supported by the evidence. […] Given the lack of US Food and Drug Administration (FDA) approved pharmacotherapies for bvFTD, current recommendations emphasize conservative, supportive non-pharmacological interventions with a focus on quality of life. […] Pharmacological interventions for bvFTD primarily target behavioral symptoms. Limited evidence supports the use of antidepressants, i.e., selective serotonin reuptake inhibitors (SSRIs), as they may quell impulsivity, compulsivity, irritability, overeating behavior, and disinhibition.

• #11 Frontiers | Precision Medicine for Frontotemporal Dementia

  https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2019.00075/full

  Behavioral disturbance (agitation or impulsivity) may also be controlled using atypical antipsychotics such as risperidone, olanzapine, and quetiapine. […] In summary, low doses of atypical antipsychotic drugs may be useful for managing behavioral disturbance, but such drugs should be used with caution in patients with FTD because of the risk of mortality associated with cardiac events and falls secondary to the side effects. […] Due to knowledge advancements in molecular biology, pathophysiology, and neuropathology, precision medicine could be applied in FTD treatment by targeting the underlying pathogenesis. […] Administering tau aggregation inhibitors, microtubule-stabilizing drugs, tau-targeted immunotherapy, and tau vaccines may be useful therapeutic approaches in patients with tau pathology.

• #12 Treatment of Frontotemporal Dementia

  https://pmc.ncbi.nlm.nih.gov/articles/PMC4920050/

  Currently, the evidence for use of antipsychotic use in FTD is limited, and all carry the risk of extrapyramidal side effects, to which FTD patients are particularly vulnerable. […] Overall, there is lack of quality evidence to recommend routine use of antiepileptic agents for mood stabilization. This class of medication has significant side effects that must be weighed against its potential benefits to patient and caregiver quality of life. […] Recent remarkable advancements in the understanding of FTLD pathophysiology, genetics and neuropathology have led to development of potentially disease modifying treatments.

• #13 Treatment of Frontotemporal Dementia

  https://escholarship.org/uc/item/5hs9c7wz

  Motor difficulties associated with FTD may present with parkinsonian symptoms or motor neuron disease, for which riluzole is indicated as therapy. […] Physical and occupational therapy remain an important corner stone of motor symptom management in FTD. Speech therapy may also help patients manage symptoms associated with aphasia, apraxia, and dysarthria. […] Recent advances in the understanding of FTLD pathophysiology and genetics have led to development of potentially disease-modifying therapies as well as symptomatic therapies aimed at ameliorating social and behavioral deficits.

• #14 Treating FTD | AFTD

  https://www.theaftd.org/for-health-professionals/treating-ftd/

  Several medications are approved for symptomatic treatment of the cognitive symptoms of AD. These are sometimes prescribed off-label for FTD patients. Cholinesterase inhibitors provide temporary stabilization or modest improvement in attention/memory, activities of daily living and global functioning in Alzheimer’s because those patients have reduced CNS acetylcholine levels. […] The N-methyl-D-aspartate receptor antagonist memantine (Namenda) is the other FDA approved cognitive enhancer for Alzheimer’s. However, research on the use of this drug in FTD using a placebo-controlled, double-blind approach has not shown it to be efficacious. […] The use of benzodiazepines such as lorazepam (Ativan); alprazolam (Xanax); clonazepam (Klonopin); and diazepam (Valium) in people with FTD may increase confusion and risk of falls and should therefore be used with caution.

• #15 Advances in Treatment of Frontotemporal Dementia | Global Brain Health Institute

  https://www.gbhi.org/news-publications/advances-treatment-frontotemporal-dementia

  In this review, the authors explored the clinical features of frontotemporal dementia (FTD), focusing on treatment. […] There are no medications that can slow FTD progression, although new therapies for the genetic forms of FTD are moving into clinical trials. […] Once a diagnosis is made, therapies should begin, focusing on the family and the patient. […] Most compounds that have been used to treat dementia of the Alzheimer’s disease type are not effective in FTD, and cholinesterase inhibitors and memantine should be avoided. […] Although the data are scant, there is some evidence that antidepressants and second-generation antipsychotics may help individual patients.

• #16 Treating FTD | AFTD

  https://www.theaftd.org/for-health-professionals/treating-ftd/

  While ongoing research is leading to a greater understanding of the molecular basis of FTD, no disease-modifying treatments have yet been approved by the U.S. Food and Drug Administration. There is no available medication or treatment that has been proven to prevent, cure or slow the decline of these disorders. […] However, many FTD symptoms can be treated. Both pharmacologic and behavioral interventions are available for symptomatic benefit of specific cognitive and behavioral features. In FTD, non-pharmacological interventions should be considered first, with medications considered in conjunction with such treatments. […] When prescribing drugs to FTD patients, clinicians should ask the patient and caregivers which symptom is most problematic and target that for treatment first. Such clarity helps to manage expectations and facilitates the family’s understanding of whether the clinician is attempting to treat a symptom that is directly related to FTD (e.g., obsessive-compulsive behaviors) or one that is a responsive behavior (e.g., patient is bored and seeking stimulation). Involving and educating caregivers in this way helps them to be better partners in monitoring the medications for their effects.

• #17

  https://www.nhs.uk/conditions/frontotemporal-dementia/treatment/

  These include: occupational therapy to identify problem areas in everyday life, such as getting dressed, and help work out practical solutions. […] Speech and language therapy to help improve any communication or swallowing problems. […] Physiotherapy to help with movement difficulties. […] Relaxation techniques such as massage, and music or dance therapy. […] Social interaction, leisure activities and other dementia activities such as memory cafes, which are drop-in sessions for people with memory problems and their carers to get support and advice. […] Strategies for challenging behaviour such as distraction techniques, a structured daily routine, and activities like doing puzzles or listening to music. […] It may also be helpful to get in touch with a support group, such as Rare Dementia Support, the Alzheimer’s Society or Dementia UK.

• #18 Treatment and support for frontotemporal dementia | Alzheimer’s Society

  https://www.alzheimers.org.uk/about-dementia/types-dementia/treatment-support-frontotemporal-dementia

  Speech and language therapy can make a big difference for someone with a language-led dementia. It uses a range of therapeutic strategies, coaching and lots of practice to keep a person communicating effectively for longer. […] It’s important to try to access speech and language therapy as soon as possible rather than waiting for a crisis, such as the loss of an essential communication skill. This is because the therapy is designed to help a person to hold on to skills for as long as possible, rather than regaining them once they’ve been lost. […] Accessing speech and language therapy through the NHS is not always easy and straightforward. However, it should be possible for anyone with a language-led dementia to request a referral by their GP or neurologist to a speech and language therapist, who can help with communication skills.

• #19 What Is Frontotemporal Dementia (FTD), and How Can Speech Therapy Help?

  https://www.expressable.com/learning-center/adults/what-is-frontotemporal-dementia-ftd-and-how-can-speech-therapy-help

  Frontotemporal dementia can be hard on everyone involved, and speech therapy serves both the client and the caregiver. […] Speech therapy provides support for daily communication situations that may be challenging. Speech therapists can also help families navigate the changes theyre experiencing, such as by recommending a support group. Many caregivers benefit from talking with other people who are going through the same situation. […] Those with bvFTD and PPA are both candidates for speech therapy. […] For people with primary progressive aphasia, speech therapy is a significant form of treatment. […] The goal of speech therapy is to maximize the persons communication skills. […] Regardless of the persons challenges, the goal of speech therapy is to keep them functioning in their daily routines as well as possible, for as long as possible.

• #20 What Are the Treatment and Care Methods for Frontotemporal Dementia? – Kensington Senior Living

  https://kensingtonseniorliving.com/frontotemporal-dementia-treatment/

  Occupational therapy helps individuals with FTD manage their daily activities and maintain a sense of purpose. Occupational therapists work to develop plans that include adaptive techniques, such as simplifying tasks and breaking them down into smaller steps to manage behavioral changes caused by FTD. […] Early intervention and proactive care are essential for managing the symptoms of FTD and improving the quality of life of your loved one with the disease. […] One option for proactive care is moving a loved one with FTD into an assisted living community or memory care community that specializes in dementia care. […] Assisted living and memory care communities can provide a safe and structured environment that can manage the symptoms of FTD and improve the individual’s quality of life.

• #21 What Are the Treatment and Care Methods for Frontotemporal Dementia? – Kensington Senior Living

  https://kensingtonseniorliving.com/frontotemporal-dementia-treatment/

  For example, antidepressants can be used to manage symptoms of depression and anxiety, which include SSRIs and SNRIs. Antipsychotic medications may be used to manage agitation or aggression, which may be symptoms caused by FTD. […] Physical therapy, speech therapy, and occupation therapy can be effective in managing the symptoms of FTD without the side effects of medication. […] Physical therapy can help people with FTD maintain their mobility and independence. Physical therapists develop customized exercise programs to address specific needs, such as improving balance, coordination, and strength. […] Speech therapy is beneficial for people with FTD who have difficulty with language skills, such as finding the right words, impaired grammar, or difficulty understanding spoken or written language.

• #22

  https://www2.hse.ie/conditions/frontotemporal-dementia/treatment/

  There is no cure for frontotemporal dementia. But there are treatments that can help manage some of the symptoms. […] Medicines cannot stop frontotemporal dementia getting worse. But for some people, it can help reduce some of the symptoms. […] Antidepressants called selective serotonin reuptake inhibitors (SSRIs) may help to control problems. […] These are sometimes prescribed if SSRIs have not worked. They can help if challenging behaviour is putting the person with dementia or other people at risk of harm. […] There are many ways to make daily tasks easier for someone with dementia. […] Occupational therapy to identify problem areas in everyday life – such as getting dressed. […] Speech and language therapy to help improve communication or swallowing problems. […] Physiotherapy to help with movement. […] Relaxation techniques – such as massage, and music or dance therapy. […] Assistive technologies can help you manage memory difficulties and support your independence and safety.

• #23 Treatment and support of frontotemporal dementia | Alzheimer Disease Foundation

  https://www.adfm.org.my/treatment-and-support-of-frontotemporal-dementia/

  Researchers are working to find effective new treatments for FTD, but there is currently no cure and the progression of the disease cannot be slowed. […] Treatment tends to focus on helping the person live well by easing their symptoms and supporting them and those around them. […] Supporting a person with FTD usually requires input from a team of professionals. […] Specialist support groups for younger people with dementia or those with FTD, as well as their carers, can provide invaluable practical and emotional support. […] If a person is found to have a gene mutation that causes FTD, birth relatives will also have to decide whether to have genetic counselling and testing themselves. […] It is important to try to manage restlessness, agitation or aggressive behaviour without drugs initially, where possible.

• #24 Frontotemporal dementia – UF Health

  https://ufhealth.org/conditions-and-treatments/frontotemporal-dementia

  Depending on the symptoms and severity of the disease, monitoring and help with personal hygiene and self-care may be needed. Eventually, there may be a need for 24-hour care and monitoring at home or in a special facility. Family counseling can help the person cope with the changes needed for home care. […] People with FTD and their family may need to seek legal advice early in the course of the disorder. Advance care directive, power of attorney, and other legal actions can make it easier to make decisions regarding the care of the person with FTD.

• #25 What Is Frontotemporal Dementia?

  https://www.alzheimers.gov/alzheimers-dementias/frontotemporal-dementia

  Be a Part of Finding Better Treatments […] There is no cure for frontotemporal dementia and no way to slow down or prevent it. However, there are ways to help manage symptoms: […] Medications, such as antidepressants and antipsychotics, may help treat certain behavioral symptoms. There are also medications that may help with movement problems, and physical and occupational therapy may provide some relief. […] Contact an academic medical center in your community to find a specialist and learn more about possible treatments. […] Support groups can also be a valuable resource for people with frontotemporal dementias and their caregivers, allowing them to share experiences and tips with others who may be in the same situation.

• #26

  https://www.nhs.uk/conditions/frontotemporal-dementia/

  There’s currently no cure for frontotemporal dementia or any treatment that will slow it down. […] But there are treatments that can help control some of the symptoms, possibly for several years. […] Treatments include: […] medicines to control some of the behavioural problems […] therapies such as physiotherapy, occupational therapy, and speech and language therapy for problems with movement, everyday tasks and communication […] dementia activities such as memory cafes, which are drop-in sessions for people with memory problems and their carers to get support and advice […] support groups who can offer tips on managing symptoms from dementia experts and people living with frontotemporal dementia, and their families.

• #27 Frontotemporal dementia: The state of treatment development – Pharmaceutical Technology

  https://www.pharmaceutical-technology.com/news/frontotemporal-dementia-the-state-of-treatment-development/

  Many have turned their attention to frontotemporal dementia (FTD) as the family of famed action star Bruce Willis announced his diagnosis last week. […] While there is no cure to this neurodegenerative condition, academics and companies are pushing through with research that could help patients and their families. […] Different approaches that are studied include antisense oligonucleotides (ASOs), and gene therapies, which are in early clinical trials. […] Efforts are also made in the study of blood marker tests that detect FTD early. […] However, multiple companies are developing treatments that target specific mutations, which could cause the condition. […] This includes Denali Therapeutics whose treatment TAK-594/DNL593 is in a Phase I/II trial. […] The therapy is specifically aimed at treating FTD patients who have mutations in their granulin gene, which encodes for the protein progranulin (PGRN).

• #28 Frontotemporal dementia (FTD) – what is it and how close is a cure? – Alzheimer’s Research UK

  https://www.alzheimersresearchuk.org/news/frontotemporal-dementia-ftd-what-is-it-and-how-close-is-a-cure/

  Teresa: Sadly, there are currently no approved treatments available that can slow, stop or cure the diseases that cause FTD. There are potential upcoming FTD treatments in clinical trials – where experimental drugs are tested in humans to see if they works and are safe – but compared to Alzheimer’s, there are relatively few clinical trials for FTD in their later stages. Because it’s relatively rare – compared to, say, Alzheimer’s – it is more of a challenge to find new treatments because we don’t know as much about it. That’s why we urgently need more research into FTD, so that we can understand the complexities of this heart-breaking condition and use this information to identify how we can treat it. […] Teresa: In my lab, we’re interested in the way the brain processes sugar and whether modifying this could help slow the damage caused by FTD. While investigating this process in fruit flies, we found a way to help flies with the C9orf72 mutation live for longer. It’s early days, but the work we’re doing suggests there might be ways to limit the damage caused by this mutation. If this also works in humans, it could be the basis of searching for new FTD treatments.

• #29 Frontiers | Precision Medicine for Frontotemporal Dementia

  https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2019.00075/full

  Collectively, advances in the understanding of genetic mutations causing FTD have created new potential therapeutic targets for the development of effective disease-modifying drugs. […] The implication of precision medicine is to enable physicians to identify highly selective and effective treatments with relatively few side effects for patients with specific illness.

• #30 Newly Initiated ASPIRE-FTD Trial Opens Door for Gene Therapy to Treat Frontotemporal Dementia

  https://www.neurologylive.com/view/newly-initiated-aspire-ftd-trial-opens-door-gene-therapy-treat-frontotemporal-dementia

  Frontotemporal dementia (FTD), a neurodegenerative disorder, is the result of damage to neurons in the frontal and temporal lobes of the brain. […] To date, there have been no effective treatments that have shown an ability to slow down or prevent FTD. […] Earlier this month, AviadoBio announced that its phase 1/2 ASPIRE-FTD trial, which evaluates the safety and efficacy of AVB-101, an investigational gene therapy for FTD, is now open and recruiting patients. […] AVB-101 is delivered as a one-time treatment administered directly to the thalamus in an MRI-guided neurosurgical procedure. […] We believe AVB-101 can be effective in potentially treating FTD-GRN as it is designed to be delivered directly to the thalamus. […] The goal of the study is to restore levels of progranulin in the brain, potentially slowing or stopping the progression of FTD-GRN.

• #31 Newly Initiated ASPIRE-FTD Trial Opens Door for Gene Therapy to Treat Frontotemporal Dementia

  https://www.neurologylive.com/view/newly-initiated-aspire-ftd-trial-opens-door-gene-therapy-treat-frontotemporal-dementia

  For ASPIRE-FTD to be considered positive, we hope to achieve the following goals: Demonstrate the safety of a one-time treatment with AVB-101 for patients with FTD-GRN, Identify a dose of AVB-101 that should restore PGRN levels, Explore the potential impact of AVB-101 on disease progression over the 5-year follow-up period. […] Gene therapies offer the potential for transformative impact or even potential cure.

• #32 Frontotemporal dementia: The state of treatment development – Pharmaceutical Technology

  https://www.pharmaceutical-technology.com/news/frontotemporal-dementia-the-state-of-treatment-development/

  In addition to gene therapy, gene silencing, which can be done using ASOs, is also an interesting approach, says Barmada. […] Examples of the ASO approach include Wave Life Sciences treatment WVE-4. […] The pathologic buildup of proteins is also a potential drug target. […] The development of biomarkers to detect these proteins should bring answers to this question soon, says Barmada. […] Biomarker tests are also needed for the early detection of the disease. […] Early detection of FTD is critical for any potential treatment. […] What this means is that it may be possible to stop the progression of disease, but not reverse any symptoms that have taken hold. […] In this regard, any effective therapy needs to be administered as early as possible in the disease’s course, says Barmada.

• #33 Racing Towards Treatments For Frontotemporal Dementia

  https://www.raceagainstdementia.com/news/racing-towards-treatments-for-frontotemporal-dementia-and-related-disorders-team-ftd

  Team FTD (frontotemporal dementia) based at the University of Cambridge, will run a trial to test new treatments for FTD, primary progressive aphasia, progressive supranuclear palsy and corticobasal syndrome. […] Team FTD is on a mission to find effective treatments for frontotemporal dementia. […] Team FTD will bypass the long, risky and expensive route of developing a new drug by repurposing an existing drug citalopram. […] If successful, the use of citalopram could be quickly implemented in clinical practice, bringing hope to families across the UK and beyond. […] Team FTD’s innovative basket design not only makes the trial more inclusive, but it also holds the potential to revolutionize how treatments are tested for complex neurological conditions. […] By focusing on immediate symptomatic relief, the team aims to bring real change to the lives of people living with these distressing behaviours. This could provide a crucial stepping-stone toward better long-term treatments for FTD and related disorders. […] The panel highlighted the trial’s potential to provide critical symptomatic relief could be life-changing for patients and families.

• #34 Patient With Frontotemporal Dementia Treated With NKGen’s Autologous NK Cell Therapy Troculeucel in Compassionate Use Context

  https://www.cgtlive.com/view/patient-frontotemporal-dementia-treated-nkgen-autologous-nk-cell-therapy-troculeucel-compassionate-use-context

  A patient has received NKGen Biotech’s troculeucel (also known as SNK01), an investigational autologous natural killer (NK) cell therapy, for the treatment of frontotemporal dementia (FTD) under a single-patient compassionate use investigational new drug (IND) cleared by the FDA. […] NKGen is assessing the potential use of troculeucel in FTD in conjunction with Mario Mendez, MD, PhD, the director of the Behavioral Neurology Program at the David Geffen School of Medicine at UCLA and Jessica Rexach, MD, PhD, the director of the Rexach Lab at UCLA Department of Neurology, and intends to pursue a full IND application for troculeucel in this context. […] Of note is that GFAP and tau are both consistently elevated in patients with FTD and we believe this supports the rationale of trying troculeucel in such patients. We are excited with the potential outcomes using our NK cell therapy in a difficult-to-treat patient population.

• #35 New genetic therapy holds promise for ALS and frontotemporal dementia | ScienceDaily

  https://www.sciencedaily.com/releases/2024/02/240216135846.htm

  Neuroscientists have developed a single-dose genetic medicine that has been proven to halt the progression of both ALS and frontotemporal dementia (FTD) in mice — and may even offer the potential to reverse some of the effects of the fatal diseases. […] The new treatment, dubbed CTx1000, targets pathological build-ups of the protein TDP-43 in cells in the brain and spinal cord, which has been associated with ALS, FTD and other forms of dementia. […] Lead author of the paper, Professor Yazi Ke, says in lab conditions, CTx1000 stopped ALS and FTD from progressing even at very advanced stages, and resolved the behavioural symptoms associated with FTD. […] „We have great hopes that when this progresses to human trials, it will not only stop people from dying from both ALS and FTD, but even allow patients to regaining some of the lost function through rehabilitation,” she says. […] There is currently no treatment for FTD.

• #36 Azthena logo with the word Azthena

  https://www.news-medical.net/news/20240219/Single-dose-genetic-medicine-halts-the-progression-of-ALS-and-frontotemporal-dementia-in-mice.aspx

  Neuroscientists at Macquarie University in Australia have developed a single-dose genetic medicine that has been proven to halt the progression of both ALS and frontotemporal dementia (FTD) in mice and may even offer the potential to reverse some of the effects of the fatal diseases. […] The new treatment, dubbed CTx1000, targets pathological build-ups of the protein TDP-43 in cells in the brain and spinal cord, which has been associated with ALS, FTD and other forms of dementia. […] Lead author of the paper, Professor Yazi Ke, says in lab conditions, CTx1000 stopped ALS and FTD from progressing even at very advanced stages, and resolved the behavioural symptoms associated with FTD. […] „We have great hopes that when this progresses to human trials, it will not only stop people from dying from both ALS and FTD, but even allow patients to regaining some of the lost function through rehabilitation,” she says. […] There is currently no treatment for FTD.

• #37 Frontiers | Precision Medicine for Frontotemporal Dementia

  https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2019.00075/full

  Frontotemporal dementia (FTD) is a common young-onset dementia presenting with heterogeneous and distinct syndromes. […] The concept of precision medicine has recently emerged, and it involves neurodegenerative disease treatment that is personalized to match an individual’s specific pattern of neuroimaging, neuropathology, and genetic variability. […] This review focuses on the approach of precision medicine to manage the clinical and biological complexities of FTD. […] Currently, no disease-modifying drugs approved by the U.S. Food and Drug Administration are available for the treatment of FTD. […] Most treatments are focused on the management of behavioral symptoms. […] The use of selective serotonin reuptake inhibitors can reduce the severity of agitation, aggressiveness, impulsivity, aberrant eating behaviors, and compulsions.

• #38

  https://www.healio.com/news/neurology/20240208/fda-grants-breakthrough-designation-to-frontotemporal-dementia-treatment

  Latozinemab is an investigational human monoclonal antibody. […] The FDA has granted breakthrough therapy designation to latozinemab, an investigational therapeutic designed to block sortilin and elevate progranulin to treat frontotemporal dementia with a progranulin gene mutation. […] According to a press release from Alector Inc., the breakthrough designation was approved based on data from the phase 2 INFRONT-2 clinical trial of latozinemab in patients with the condition. […] Breakthrough designation is granted by the FDA to expedite development and review of drugs developed to treat a serious condition, when preliminary clinical evidence indicates the drug may demonstrate substantial improvement over currently available therapies. […] Alector further stated in the release that latozinemab is currently under investigation in the phase 3 INFRONT-3 study, which achieved target enrollment in October 2023.

• #39 TMS Therapy for Frontotemporal Dementia | Neurotherapeutix

  https://neurotherapeutixnyc.com/conditions/tms-for-frontotemporal-dementias/

  At Neurotherapeutix, we offer advanced frontotemporal dementia treatment using fMRI-guided transcranial magnetic stimulation (TMS), a non-invasive, precision-based approach to supporting brain function and improving symptoms. […] This personalized TMS approach for frontotemporal dementia is tailored to each patient’s unique brain patterns. It can benefit people who haven’t improved with standard treatments or who experience troublesome side effects from medications. […] Neurotherapeutix is the only clinic in the U.S. using patented functional imaging-guided TMS to treat neurodegenerative disorders like frontotemporal dementia. Our comprehensive care includes: Precision brain mapping using rsfMRI. Advanced, data-driven TMS treatment. Ongoing progress tracking with quantitative biomarkers. Caring clinical specialists explicitly trained in frontotemporal dementia treatment, using proven approaches customized to each patient’s specific needs and stage of the disease. […] At Neurotherapeutix, we provide advanced, noninvasive treatment options to improve symptoms and preserve function for as long as possible.

• #40 Frontotemporal dementia – Symptoms, diagnosis and treatment | BMJ Best Practice US

  https://bestpractice.bmj.com/topics/en-us/968

  Frontotemporal dementia manifests primarily as disruption in personality and social conduct, or as a primary language disorder. […] Treatment is supportive, combining medications with nonpharmacologic and behavioral interventions, caregiver guidance, community services, and social work involvement.

• #41 Frontotemporal Dementia (FTD) – Neurologic Disorders – Merck Manual Professional Edition

  https://www.merckmanuals.com/professional/neurologic-disorders/delirium-and-dementia/frontotemporal-dementia-ftd

  There is no specific treatment for frontotemporal dementia. Treatment is generally supportive. For example, the environment should be bright, cheerful, and familiar, and it should be designed to reinforce orientation (eg, placement of large clocks and calendars in the room). Measures to ensure patient safety (eg, signal monitoring systems for patients who wander) should be implemented. […] Symptoms are treated as needed.

• #42 Treatment And Management Of Frontotemporal Dementia: Current Approaches To Managing FTD Symptoms And Progression – Klarity Health Library

  https://my.klarity.health/treatment-and-management-of-frontotemporal-dementia-current-approaches-to-managing-ftd-symptoms-and-progression/

  If you are living independently, your household safety should be assessed to reduce your risk of sustaining damage from incidents, such as falls, burns, or poisoning. […] This is usually in the form of cognitive behavioural therapy (CBT), which is a type of therapy that encourages you to consider how your thoughts and feelings can influence your behaviour. […] This treatment is especially beneficial for PPA since your speech and language is likely to be impaired. […] Clinical trials are being conducted that use strategies to lower the accumulation of tau in neurons. […] By altering levels of tau in the brain, it is hoped that the rate at which FTD causes behavioural and cognitive decline will reduce, allowing you to have a good quality of life for as long as possible. […] Palliative care aims to make you as comfortable as possible by managing symptoms, such as pain. […] Finally, palliative care is essential for supporting patients and carers alike towards the end stages of FTD.

• #43 Frontotemporal dementia: MedlinePlus Medical EncyclopediaLock

  https://medlineplus.gov/ency/article/000744.htm

  Depending on the symptoms and severity of the disease, monitoring and help with personal hygiene and self-care may be needed. […] Eventually, there may be a need for 24-hour care and monitoring at home or in a special facility. […] Family counseling can help the person cope with the changes needed for home care. […] People with FTD and their family may need to seek legal advice early in the course of the disorder.

• #44 What Are the Treatment and Care Methods for Frontotemporal Dementia? – Kensington Senior Living

  https://kensingtonseniorliving.com/frontotemporal-dementia-treatment/

  By recognizing the symptoms of FTD early and making the move to assisted living, caregivers can give their loved ones the best chance for a longer, happier life surrounded by professionals who can provide the specialized care they need. […] At Kensington Senior Living, we understand the challenges that come with caring for a loved one with frontotemporal dementia. […] Our upscale independent living, assisted living, and memory care communities located in New York, Maryland, Virginia, and California provide specialized care and support for individuals with FTD, while also offering all the amenities and services of a high-end resort.

• #45 Treating FTD | AFTD

  https://www.theaftd.org/for-health-professionals/treating-ftd/

  Many people with FTD present with parkinsonism including tremors, rigidity, movement difficulties and bradykinesia. PSP and CBD are FTD disorders that are characterized by atypical Parkinson symptoms. Unfortunately, parkinsonism in FTD is not very treatable. […] Another class of medications that needs to be used with extreme caution for behaviors in FTD are the psychostimulant agents [e.g., methylphenidate (Ritalin), dextroamphetamine (Dexedrine), etc.]. Adverse outcomes are not rare and these drugs should be a last resort. […] Since the medication management of this patient group is complicated, primary care physicians may want to refer FTD patients with behavior problems to academic centers specializing in FTD. Unfortunately, there are no medications that help with the poor judgment and inappropriate behaviors that are so common in FTD. Non-pharmacological interventions – including OT, PT, speech therapy, behavioral and environmental changes, and support – are the most effective interventions available today. These are essential as supplement and general alternative to medications. Caregiver education is key. Caregivers should also be referred to AFTD for advice on available resources in their area.

• #46 Frontotemporal Dementia: Symptoms and Treatment | Doctor

  https://patient.info/doctor/frontotemporal-dementia

  There is no treatment to stop the progression of FTD. Anticholinesterase (AChE) inhibitors or memantine should not be used. […] Management is therefore directed at alleviating symptoms, providing support and information for those with FTD and their families, and keeping them safe. This will involve multidisciplinary health and social care, which needs to be co-ordinated. Referrals to other agencies will be required, which may include geriatric medicine, psychiatry, psychology, social work, occupational therapy, speech and language therapy, physiotherapy and community nursing. […] Selective serotonin reuptake inhibitors (SSRIs) may be helpful in modifying behavioural symptoms. Evidence is limited to small studies. […] Atypical antipsychotics are used where there are severe behavioural problems such as agitation and psychosis. These are only used cautiously and when SSRIs have failed, as those with FTD are at higher risk of extrapyramidal side-effects.

• #47 Frontotemporal dementia (FTD) – what is it and how close is a cure? – Alzheimer’s Research UK

  https://www.alzheimersresearchuk.org/news/frontotemporal-dementia-ftd-what-is-it-and-how-close-is-a-cure/

  Jess: Alzheimer’s Research UK are proud to be funding studies like Teresa’s, which are giving us crucial insight into how we might be able to treat FTD in the future. We might be a way off yet, but it’s fundamental research like Teresa’s which is so crucial to finding a future cure. […] We also fund a number of other projects related to FTD, such as identifying how certain genetic mutations lead to the condition. In combination, we hope these projects will eventually allow us to detect FTD earlier, better understand its risk factors and ultimately find a cure.

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