Materiały źródłowe

• #1 Liver Disease: Signs & Symptoms, Causes, Stages, Treatment

  https://my.clevelandclinic.org/health/diseases/17179-liver-disease

  When healthcare providers refer to liver disease, theyre usually referring to chronic conditions that do progressive damage to your liver over time. Viral infections, toxic poisoning and certain metabolic conditions are among the common causes of chronic liver disease. […] There are over 100 types of liver disease, but they fall into a handful of subtypes. Causes include: Viral infections. Viral hepatitis infections that become chronic can cause chronic hepatitis, including hepatitis B and hepatitis C. Alcohol-induced hepatitis. Heavy alcohol use can cause acute or chronic hepatitis. If it goes on long enough, it can cause cirrhosis and liver failure. Toxic hepatitis. Chronic overexposure to toxins, such as industrial chemicals or drugs, can cause acute or chronic hepatitis. Non-alcohol related fatty liver disease. Metabolic conditions associated with obesity, high blood sugar and high blood lipids can cause excess fat storage in your liver, which can cause inflammation (non-alcohol related steatohepatitis). Biliary stasis. Congenital (present at birth) conditions that obstruct or stall the flow of bile through your bile ducts can cause bile to build up and injure your liver, including biliary atresia and cystic fibrosis. Non-congenital causes include biliary stricture and gallstones. Autoimmune diseases. Autoimmune conditions can cause chronic inflammation and scarring in your liver or your bile ducts, including autoimmune hepatitis, primary biliary cholangitis and primary sclerosing cholangitis. Inherited metabolic disorders. Disorders that cause toxic products to build up in your blood such as glycogen storage disease (GSD), Wilson disease, hemochromatosis and Gaucher disease can cause chronic liver damage. Cardiovascular diseases. Conditions that affect blood flow to and from your liver including Budd-Chiari syndrome, ischemia, arterial diseases and right-sided heart failure can cause chronic liver damage.

• #2 Chronic Liver Disease – StatPearls – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK554597/

  Chronic liver disease (CLD) is a continuous process of inflammation, destruction, and regeneration of liver parenchyma, which leads to fibrosis and cirrhosis. […] The spectrum of etiologies is broad for chronic liver disease, which includes toxins, alcohol abuse for a prolonged time, infection, autoimmune diseases, genetic and metabolic disorders. […] The following are the most common etiologies: […] Alcoholic liver disease is a spectrum of disease which includes alcoholic fatty liver with or without hepatitis, alcohol hepatitis (reversible because of acute ingestion) to cirrhosis (irreversible). […] NAFLD has an association with metabolic syndrome (obesity, hyperlipidemia, and diabetes mellitus). […] Chronic hepatitis B, C, and D infections are the most common causes of chronic liver disease in East Asia and Sub-Saharan Africa.

• #3 Liver Disease: Types of Liver Problems, Causes, and More

  https://www.healthline.com/health/liver-diseases

  Liver disease is a general term that refers to any condition affecting your liver. These conditions may develop for different reasons, but they can all damage your liver and affect its function. […] Many conditions can affect your liver. Heres a look at some of the main ones. […] Hepatitis is defined as an inflammation of the liver. When that inflammation is caused by a virus, its referred to as viral hepatitis. Hepatitis can cause liver damage, making it difficult for your liver to function as it should. […] Fat buildup in the liver can lead to fatty liver disease. There are two types of fatty liver disease. These two types can manifest alone, or they can overlap: alcoholic fatty liver disease, which is caused by heavy alcohol consumption […] nonalcoholic fatty liver disease, which is caused by other factors experts are still trying to understand.

• #4 The Stages of Liver Disease – American Liver Foundation

  https://liverfoundation.org/about-your-liver/how-liver-diseases-progress/

  In America, liver disease affects millions and is on the rise. Did you know there are more than 100 different types of liver disease? Living with long-term, chronic liver disease can cause damage to your liver. […] Common Causes of Liver Disease: Viruses, Genetics, Autoimmune disease, Excessive use of alcohol, Poor diet and/or obesity, Reactions to medications, street drugs, or toxic chemicals. […] Most liver diseases damage your liver in similar ways and for many, the progression of liver disease looks the same regardless of the underlying disease. […] Cirrhosis is where your liver is severely scarred and permanently damaged. While the word cirrhosis is most commonly heard when people discuss alcohol-induced liver disease, cirrhosis is caused by many forms of liver disease. […] Liver cancer is cancer that begins in the cells of your liver. While several types of cancer can form in the liver, the most common type of liver cancer is hepatocellular carcinoma, or HCC, which begins in the main type of liver cells (hepatocytes).

• #5 Liver disease

  https://www.nhs.uk/conditions/liver-disease/

  There are many different types of liver disease. […] There are several types of liver disease, which can have different causes. […] Common types of liver disease and the possible causes Condition Possible causes Alcohol-related liver disease Regularly drinking too much alcohol Non-alcoholic fatty liver disease Being very overweight (obese) this may cause fat to build up in the liver Hepatitis Catching a viral infection or regularly drinking too much alcohol Haemochromatosis A gene that runs in families and may be passed from parents to children Primary biliary cholangitis May be caused by a problem with the immune system. […] The 3 main causes of liver disease are: obesity, an undiagnosed hepatitis infection, alcohol misuse.

• #6 Liver Disease: Symptoms, Causes & Treatment | Medcare

  https://www.medcare.ae/en/health-library/liver-disease-symptoms-causes-and-treatment.html

  Liver disease comes in many forms. […] The disease can be caused by viral infection (hepatitis), by lifestyle factors such as alcohol consumption, genetics and autoimmune conditions, characterised by the immune system attacking healthy cells. […] The three leading causes of liver disease are: Obesity, Undiagnosed hepatitis infection, Alcohol abuse. […] There are numerous lifestyle factors that contribute to liver disease, including: Lifestyle, Diet, Exercise, Genetics, Pre-existing conditions. […] Complications of liver disease can vary, depending on the cause of the liver problems. […] A diseased liver can cause portal hypertension – high blood pressure in the portal vein – which supplies blood to the liver. […] When the liver becomes severely scarred (cirrhosis), it creates increased blood pressure around the intestines, a dangerous complication of liver disease.

• #7 Risks and causes – British Liver Trust

  https://britishlivertrust.org.uk/information-and-support/risks-and-causes/

  Anyone can develop liver disease, but there are some things that make it more likely. Some causes of liver disease, such as genetic and autoimmune diseases, are totally outside our control. […] Together alcohol, excess bodyweight, and viral hepatitis are behind 9 in 10 cases of liver disease.

• #8 Risks and causes – British Liver Trust

  https://britishlivertrust.org.uk/information-and-support/risks-and-causes/

  Anyone can develop liver disease, but there are some things that make it more likely. Some causes of liver disease, such as genetic and autoimmune diseases, are totally outside our control. […] Together alcohol, excess bodyweight, and viral hepatitis are behind 9 in 10 cases of liver disease.

• #9 Liver diseases: epidemiology, causes, trends and predictions | Signal Transduction and Targeted Therapy

  https://www.nature.com/articles/s41392-024-02072-z

  The removal of causative agents such as ethanol and viruses does not always prevent progression to cirrhosis, suggesting that the underlying mechanisms driving disease onset and progression are incompletely understood. […] Liver disease stands as a leading cause of global mortality. […] Liver cancer, a terminal outcome of liver disease, accounted for approximately 830,000 deaths in 2020, representing 8.3% of global cancer-related deaths. […] Chronic liver conditions, on the other hand, typically arise from factors like alcohol consumption, hepatitis B virus (HBV), and hepatitis C virus (HCV) infections, along with a rising incidence of metabolic dysfunction-associated steatotic liver disease (MASLD) globally. […] The leading causes of cirrhosis include MASLD (60%), HBV (29%), HCV (9%), and ALD (2%).

• #10 Liver Disease: Signs & Symptoms, Causes, Stages, Treatment

  https://my.clevelandclinic.org/health/diseases/17179-liver-disease

  When healthcare providers refer to liver disease, theyre usually referring to chronic conditions that do progressive damage to your liver over time. Viral infections, toxic poisoning and certain metabolic conditions are among the common causes of chronic liver disease. […] There are over 100 types of liver disease, but they fall into a handful of subtypes. Causes include: Viral infections. Viral hepatitis infections that become chronic can cause chronic hepatitis, including hepatitis B and hepatitis C. Alcohol-induced hepatitis. Heavy alcohol use can cause acute or chronic hepatitis. If it goes on long enough, it can cause cirrhosis and liver failure. Toxic hepatitis. Chronic overexposure to toxins, such as industrial chemicals or drugs, can cause acute or chronic hepatitis. Non-alcohol related fatty liver disease. Metabolic conditions associated with obesity, high blood sugar and high blood lipids can cause excess fat storage in your liver, which can cause inflammation (non-alcohol related steatohepatitis). Biliary stasis. Congenital (present at birth) conditions that obstruct or stall the flow of bile through your bile ducts can cause bile to build up and injure your liver, including biliary atresia and cystic fibrosis. Non-congenital causes include biliary stricture and gallstones. Autoimmune diseases. Autoimmune conditions can cause chronic inflammation and scarring in your liver or your bile ducts, including autoimmune hepatitis, primary biliary cholangitis and primary sclerosing cholangitis. Inherited metabolic disorders. Disorders that cause toxic products to build up in your blood such as glycogen storage disease (GSD), Wilson disease, hemochromatosis and Gaucher disease can cause chronic liver damage. Cardiovascular diseases. Conditions that affect blood flow to and from your liver including Budd-Chiari syndrome, ischemia, arterial diseases and right-sided heart failure can cause chronic liver damage.

• #11 Liver Diseases | MedlinePlus

  https://medlineplus.gov/liverdiseases.html

  There are many kinds of liver diseases: […] Diseases caused by viruses, such as hepatitis A, hepatitis B, and hepatitis C […] Diseases caused by drugs, poisons, or too much alcohol. Examples include fatty liver disease and cirrhosis. […] Inherited diseases, such as hemochromatosis and Wilson disease.

• #12 What Causes Liver Damage & Disease? | Hep C & Liver Health | Hepatitis NSW

  https://www.hep.org.au/liver-health/what-causes-liver-damage-and-disease/

  Liver damage is usually caused by viral infections, lifestyle, diet and our bodys immune system. If left untreated liver damage can cause serious health problems. […] Hepatitis B is the most common liver infection in the world, people mostly get it at birth if their mother has hepatitis B. […] Hepatitis C is an easily cured liver infection, caused by the hepatitis C virus. The new treatments for hepatitis C cure up to 95% of people and only take around 12 weeks. If left untreated, hepatitis C can cause serious health problems. […] Alcohol-related hepatitis is a very common form of liver disease in Australia. As the name suggests, it is caused by excessive use of alcohol. […] Non-alcoholic fatty liver disease (NAFLD) happens when fat begins to build up in your liver. NAFLD can be caused by a range of conditions but its usually linked to being overweight or obese.

• #13 Liver Cancer Causes, Risk Factors, and Prevention – NCI

  https://www.cancer.gov/types/liver/what-is-liver-cancer/causes-risk-factors

  The most common type of liver cancer in adults, hepatocellular carcinoma (HCC), typically develops in people with chronic (long-lasting) liver disease caused by hepatitis virus infection or cirrhosis. […] Chronic HBV infection is the leading cause of liver cancer in Asia and Africa. […] Chronic HCV infection is the leading cause of liver cancer in North America, Europe, and Japan. […] The risk of developing liver cancer is increased for people who have cirrhosis, a disease in which healthy liver tissue is replaced by scar tissue. […] Heavy alcohol use can cause cirrhosis, which is a risk factor for liver cancer. […] Having NASH-related cirrhosis increases the risk of developing liver cancer. […] Cigarette smoking has been linked to a higher risk of liver cancer. […] Certain rare medical and genetic conditions may increase the risk of liver cancer.

• #14 What Causes Liver Damage & Disease? | Hep C & Liver Health | Hepatitis NSW

  https://www.hep.org.au/liver-health/what-causes-liver-damage-and-disease/

  Liver damage is usually caused by viral infections, lifestyle, diet and our bodys immune system. If left untreated liver damage can cause serious health problems. […] Hepatitis B is the most common liver infection in the world, people mostly get it at birth if their mother has hepatitis B. […] Hepatitis C is an easily cured liver infection, caused by the hepatitis C virus. The new treatments for hepatitis C cure up to 95% of people and only take around 12 weeks. If left untreated, hepatitis C can cause serious health problems. […] Alcohol-related hepatitis is a very common form of liver disease in Australia. As the name suggests, it is caused by excessive use of alcohol. […] Non-alcoholic fatty liver disease (NAFLD) happens when fat begins to build up in your liver. NAFLD can be caused by a range of conditions but its usually linked to being overweight or obese.

• #15 Liver Cancer Causes, Risk Factors, and Prevention – NCI

  https://www.cancer.gov/types/liver/what-is-liver-cancer/causes-risk-factors

  The most common type of liver cancer in adults, hepatocellular carcinoma (HCC), typically develops in people with chronic (long-lasting) liver disease caused by hepatitis virus infection or cirrhosis. […] Chronic HBV infection is the leading cause of liver cancer in Asia and Africa. […] Chronic HCV infection is the leading cause of liver cancer in North America, Europe, and Japan. […] The risk of developing liver cancer is increased for people who have cirrhosis, a disease in which healthy liver tissue is replaced by scar tissue. […] Heavy alcohol use can cause cirrhosis, which is a risk factor for liver cancer. […] Having NASH-related cirrhosis increases the risk of developing liver cancer. […] Cigarette smoking has been linked to a higher risk of liver cancer. […] Certain rare medical and genetic conditions may increase the risk of liver cancer.

• #16 Signs & Symptoms of Liver Failure, Causes, Treatments

  https://my.clevelandclinic.org/health/diseases/17819-liver-failure

  Acute liver failure usually occurs in people with no prior history of liver disease. It happens when something overwhelmingly injures your liver. This might be an overwhelming toxic load that your liver encounters as its filtering your blood. It can also be an acute infection that attacks your liver directly. […] Chronic liver failure is the result of cirrhosis. The scarring process prevents blood and oxygen from nourishing your liver tissues, causing cell death. As liver cells die, your liver functions less and less. Cirrhosis is the result of long-term hepatitis, which many chronic liver diseases can cause. […] Causes include: Viral infections, including viral hepatitis A, B, D and E. Less commonly, Epstein-Barr Virus, cytomegalovirus (CMV), varicella zoster virus or herpes simplex virus may cause it.

• #17 Chronic Liver Disease – StatPearls – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK554597/

  Chronic liver disease (CLD) is a continuous process of inflammation, destruction, and regeneration of liver parenchyma, which leads to fibrosis and cirrhosis. […] The spectrum of etiologies is broad for chronic liver disease, which includes toxins, alcohol abuse for a prolonged time, infection, autoimmune diseases, genetic and metabolic disorders. […] The following are the most common etiologies: […] Alcoholic liver disease is a spectrum of disease which includes alcoholic fatty liver with or without hepatitis, alcohol hepatitis (reversible because of acute ingestion) to cirrhosis (irreversible). […] NAFLD has an association with metabolic syndrome (obesity, hyperlipidemia, and diabetes mellitus). […] Chronic hepatitis B, C, and D infections are the most common causes of chronic liver disease in East Asia and Sub-Saharan Africa.

• #18 Cirrhosis – Wikipedia

  https://en.wikipedia.org/wiki/Cirrhosis

  Globally, 57% of cirrhosis is attributable to either hepatitis B (30%) or hepatitis C (27%). […] Alcohol use disorder is another major cause, accounting for about 20-40% of the cases. […] Alcoholic liver disease (ALD, or alcoholic cirrhosis) develops for 10-20% of individuals who drink heavily for a decade or more. […] In non-alcoholic fatty liver disease (NAFLD), fat builds up in the liver and eventually causes scar tissue. […] Chronic hepatitis C, an infection with the hepatitis C virus, causes inflammation of the liver and a variable grade of damage to the organ. […] Chronic hepatitis B causes liver inflammation and injury that over several decades can lead to cirrhosis.

• #19 Signs & Symptoms of Liver Failure, Causes, Treatments

  https://my.clevelandclinic.org/health/diseases/17819-liver-failure

  Acute liver failure usually occurs in people with no prior history of liver disease. It happens when something overwhelmingly injures your liver. This might be an overwhelming toxic load that your liver encounters as its filtering your blood. It can also be an acute infection that attacks your liver directly. […] Chronic liver failure is the result of cirrhosis. The scarring process prevents blood and oxygen from nourishing your liver tissues, causing cell death. As liver cells die, your liver functions less and less. Cirrhosis is the result of long-term hepatitis, which many chronic liver diseases can cause. […] Causes include: Viral infections, including viral hepatitis A, B, D and E. Less commonly, Epstein-Barr Virus, cytomegalovirus (CMV), varicella zoster virus or herpes simplex virus may cause it.

• #20 Acute liver failure – Symptoms and causes – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/acute-liver-failure/symptoms-causes/syc-20352863

  Acute liver failure occurs when liver cells are seriously damaged and are no longer able to function. Possible causes include: […] Taking too much acetaminophen (Tylenol, others) is the most common cause of acute liver failure in the United States. […] Hepatitis A, hepatitis B and hepatitis E increase the risk of acute liver failure. Other viruses that can increase risk include Epstein-Barr virus, cytomegalovirus and herpes simplex virus. […] Some prescription medicines, including antibiotics, nonsteroidal anti-inflammatory drugs and anticonvulsants, can cause acute liver failure. […] Herbal drugs and supplements, including kava, ephedra, skullcap and pennyroyal, have been linked to acute liver failure. […] Toxins that can cause acute liver failure include the poisonous wild mushroom Amanita phalloides, which is sometimes mistaken for one that is safe to eat.

• #21

  https://www.aurorahealthcare.org/services/gastroenterology-colorectal-surgery/liver-disease

  Liver disease is a common health problem, affecting millions of people all over the world. It can be caused by several factors, including alcohol consumption, viral infections, genetics and certain medications. […] Some liver diseases are caused by viruses like hepatitis A, hepatitis B and hepatitis C. Others are inherited or are caused by drugs, chemicals or excessive alcohol consumption. […] Alcoholic liver disease is caused by excessive alcohol consumption. ALD can lead to inflammation, fibrosis and cirrhosis of the liver. […] Several factors may lead to various types of liver disease, including excess consumption of fatty or fried foods and excessive alcohol use. […] Alcohol consumption is a leading cause of liver disease. When alcohol is metabolized by the liver, it produces a toxic substance that can damage liver cells. Other common causes of liver disease include genetics, inherited conditions, medications and toxins.

• #22 Cirrhosis – Wikipedia

  https://en.wikipedia.org/wiki/Cirrhosis

  Globally, 57% of cirrhosis is attributable to either hepatitis B (30%) or hepatitis C (27%). […] Alcohol use disorder is another major cause, accounting for about 20-40% of the cases. […] Alcoholic liver disease (ALD, or alcoholic cirrhosis) develops for 10-20% of individuals who drink heavily for a decade or more. […] In non-alcoholic fatty liver disease (NAFLD), fat builds up in the liver and eventually causes scar tissue. […] Chronic hepatitis C, an infection with the hepatitis C virus, causes inflammation of the liver and a variable grade of damage to the organ. […] Chronic hepatitis B causes liver inflammation and injury that over several decades can lead to cirrhosis.

• #23 Liver Diseases: Liver Problems Types, Symptoms & Causes

  https://liverfoundation.org/liver-diseases/

  Alcohol-related liver disease is caused by excessive consumption of alcohol and is a common, but preventable, disease. […] An autoimmune liver disease develops when your own immune system mistakes normal, healthy tissue for a foreign body. […] Viral hepatitis is liver inflammation due to a viral infection.

• #24 Chronic Liver Disease – StatPearls – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK554597/

  Chronic liver disease (CLD) is a continuous process of inflammation, destruction, and regeneration of liver parenchyma, which leads to fibrosis and cirrhosis. […] The spectrum of etiologies is broad for chronic liver disease, which includes toxins, alcohol abuse for a prolonged time, infection, autoimmune diseases, genetic and metabolic disorders. […] The following are the most common etiologies: […] Alcoholic liver disease is a spectrum of disease which includes alcoholic fatty liver with or without hepatitis, alcohol hepatitis (reversible because of acute ingestion) to cirrhosis (irreversible). […] NAFLD has an association with metabolic syndrome (obesity, hyperlipidemia, and diabetes mellitus). […] Chronic hepatitis B, C, and D infections are the most common causes of chronic liver disease in East Asia and Sub-Saharan Africa.

• #25

  https://www.aurorahealthcare.org/services/gastroenterology-colorectal-surgery/liver-disease

  Liver disease is a common health problem, affecting millions of people all over the world. It can be caused by several factors, including alcohol consumption, viral infections, genetics and certain medications. […] Some liver diseases are caused by viruses like hepatitis A, hepatitis B and hepatitis C. Others are inherited or are caused by drugs, chemicals or excessive alcohol consumption. […] Alcoholic liver disease is caused by excessive alcohol consumption. ALD can lead to inflammation, fibrosis and cirrhosis of the liver. […] Several factors may lead to various types of liver disease, including excess consumption of fatty or fried foods and excessive alcohol use. […] Alcohol consumption is a leading cause of liver disease. When alcohol is metabolized by the liver, it produces a toxic substance that can damage liver cells. Other common causes of liver disease include genetics, inherited conditions, medications and toxins.

• #26 Alcohol-related Liver Disease > Fact Sheets > Yale Medicine

  https://www.yalemedicine.org/conditions/alcohol-related-liver-disease

  Liver damage caused by excessive consumption of alcohol. […] Chronic drinking can also result in a condition known as alcohol-related liver disease. This is a disease in which alcohol useespecially long-term, excessive alcohol consumptiondamages the liver, preventing it from functioning as it should. […] Alcohol-related liver disease (ALD) occurs when the liver is damaged by excessive consumption of alcohol, usually over a period of several years. […] The liver also filters and removes toxic substanceslike alcoholfrom the blood. […] So, if someone drinks too much alcohol, the liver can become damaged by substances produced during the metabolism of that alcohol, the buildup of fats in the liver, and inflammation and fibrosis. […] In general, people who drink more alcohol are at elevated risk for alcohol-related liver disease. […] Several other factors may contribute to an elevated risk for ALD, including: Female gender. Women are more susceptible to ALD than men. […] Alcohol-related liver disease refers to a spectrum of disorders, and treatments vary based on the severity of liver disease.

• #27 Alcohol Related Liver Disease | University of Michigan Health

  https://www.uofmhealth.org/conditions-treatments/digestive-and-liver-health/alcohol-related-liver-disease

  Alcohol related liver disease (ALD) is the result of drinking more alcohol than the liver can process, which damages the organ. […] If too much alcohol is ingested repeatedly over time, even without getting drunk, liver damage can silently begin. […] ALD is both preventable and can be fatal. […] Up to 35 percent of heavy drinkers develop alcohol associated hepatitis, which can be mild or severe. […] Alcohol related cirrhosis occurs when the entire liver is scarred, causing the liver to shrink and harden. […] Between 10 to 20 percent of heavy drinkers develop cirrhosis — typically after 10 or more years of drinking. […] Adding alcohol to a liver already taxed by hepatitis increases the risk of developing liver disease, as well as liver cancer.

• #28 Understanding liver disease in women | Northwell Health

  https://www.northwell.edu/katz-institute-for-womens-health/articles/liver-disease

  Liver is the only organ that can repair itself but various diseases can cause reversible and irreversible damage. Approximately 5.5 million Americans are currently living with chronic liver disease, and up to 30% of adults have excessive fat in their liver which could lead to more serious liver disease (source: American Liver Foundation). There are more than 100 different liver diseases with some more common in women, including: […] Alcoholic liver disease is more common in women because women absorb more alcohol relative to their body size than men. As little as two drinks a day may be enough to cause this condition. […] Approximately 80 percent of patients diagnosed with autoimmune hepatitis are women. […] Non-alcoholic fatty liver disease affects 60 to 80 million Americans. Excessive fat can be toxic to the liver and cause inflammation. It is the leading cause of cirrhosis in the US with risk factors that include diabetes and obesity.

• #29 Liver Disease: Types of Liver Problems, Causes, and More

  https://www.healthline.com/health/liver-diseases

  Chronic liver failure typically happens when a significant part of your liver is damaged and cant function properly. […] Certain things can make you more likely to develop certain liver diseases. One of the most well-known risk factors is heavy drinking, which the Centers for Disease Control and Prevention (CDC) defines as more than 8 alcoholic drinks per week for women and more than 15 drinks per week for men. […] While not all liver disease or damage can be prevented, lifestyle choices can make a big difference when it comes to keeping your liver healthy. […] Many liver diseases are chronic, meaning they last for years and may never go away. But even chronic liver diseases can usually be managed. […] The complications of untreated or unmanaged liver disease can lead to cirrhosis, severe scarring that cannot be reversed. If cirrhosis has gone too far, a liver transplant may be your only option.

• #30 Liver Disease: Types of Liver Problems, Causes, and More

  https://www.healthline.com/health/liver-diseases

  Liver disease is a general term that refers to any condition affecting your liver. These conditions may develop for different reasons, but they can all damage your liver and affect its function. […] Many conditions can affect your liver. Heres a look at some of the main ones. […] Hepatitis is defined as an inflammation of the liver. When that inflammation is caused by a virus, its referred to as viral hepatitis. Hepatitis can cause liver damage, making it difficult for your liver to function as it should. […] Fat buildup in the liver can lead to fatty liver disease. There are two types of fatty liver disease. These two types can manifest alone, or they can overlap: alcoholic fatty liver disease, which is caused by heavy alcohol consumption […] nonalcoholic fatty liver disease, which is caused by other factors experts are still trying to understand.

• #31 Fatty liver — symptoms, causes and treatment | healthdirect

  https://www.healthdirect.gov.au/fatty-liver

  Fatty liver is usually due to a combination of factors over a long period of time. […] The most common causes of fatty liver are: being obese or overweight especially around the abdomen (tummy), having type 2 diabetes mellitus or insulin resistance, having high blood cholesterol or high triglycerides, drinking too much alcohol. […] Less common causes are: an underactive thyroid, certain medicines, having polycystic ovary syndrome (PCOS). […] There are 2 main types of fatty liver disease: metabolic associated fatty liver disease and alcohol-related fatty liver disease. […] Metabolic associated fatty liver disease is caused by: being overweight or obese, not being active enough. […] Alcohol-related fatty liver disease is caused by drinking too much alcohol over long periods.

• #32 Understanding liver disease in women | Northwell Health

  https://www.northwell.edu/katz-institute-for-womens-health/articles/liver-disease

  Liver is the only organ that can repair itself but various diseases can cause reversible and irreversible damage. Approximately 5.5 million Americans are currently living with chronic liver disease, and up to 30% of adults have excessive fat in their liver which could lead to more serious liver disease (source: American Liver Foundation). There are more than 100 different liver diseases with some more common in women, including: […] Alcoholic liver disease is more common in women because women absorb more alcohol relative to their body size than men. As little as two drinks a day may be enough to cause this condition. […] Approximately 80 percent of patients diagnosed with autoimmune hepatitis are women. […] Non-alcoholic fatty liver disease affects 60 to 80 million Americans. Excessive fat can be toxic to the liver and cause inflammation. It is the leading cause of cirrhosis in the US with risk factors that include diabetes and obesity.

• #33 Liver diseases: epidemiology, causes, trends and predictions | Signal Transduction and Targeted Therapy

  https://www.nature.com/articles/s41392-024-02072-z

  As a highly complex organ with digestive, endocrine, and immune-regulatory functions, the liver is pivotal in maintaining physiological homeostasis through its roles in metabolism, detoxification, and immune response. Various factors including viruses, alcohol, metabolites, toxins, and other pathogenic agents can compromise liver function, leading to acute or chronic injury that may progress to end-stage liver diseases. […] Liver diseases represent a wide array of disorders characterized by hepatocyte injury, inflammatory cell infiltration, and HSC activation, which cumulatively impair liver function and disrupt its architecture. […] Acute liver diseases often result from hepatotropic virus infections, though drug-induced liver injury (DILI) is also becoming increasingly prevalent worldwide. Chronic liver conditions, on the other hand, typically arise from factors like alcohol consumption, hepatitis B virus (HBV), and hepatitis C virus (HCV) infections, along with a rising incidence of metabolic dysfunction-associated steatotic liver disease (MASLD) globally.

• #34 Chronic Liver Disease – StatPearls – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK554597/

  Chronic liver disease (CLD) is a continuous process of inflammation, destruction, and regeneration of liver parenchyma, which leads to fibrosis and cirrhosis. […] The spectrum of etiologies is broad for chronic liver disease, which includes toxins, alcohol abuse for a prolonged time, infection, autoimmune diseases, genetic and metabolic disorders. […] The following are the most common etiologies: […] Alcoholic liver disease is a spectrum of disease which includes alcoholic fatty liver with or without hepatitis, alcohol hepatitis (reversible because of acute ingestion) to cirrhosis (irreversible). […] NAFLD has an association with metabolic syndrome (obesity, hyperlipidemia, and diabetes mellitus). […] Chronic hepatitis B, C, and D infections are the most common causes of chronic liver disease in East Asia and Sub-Saharan Africa.

• #35 Fatty liver — symptoms, causes and treatment | healthdirect

  https://www.healthdirect.gov.au/fatty-liver

  Fatty liver is usually due to a combination of factors over a long period of time. […] The most common causes of fatty liver are: being obese or overweight especially around the abdomen (tummy), having type 2 diabetes mellitus or insulin resistance, having high blood cholesterol or high triglycerides, drinking too much alcohol. […] Less common causes are: an underactive thyroid, certain medicines, having polycystic ovary syndrome (PCOS). […] There are 2 main types of fatty liver disease: metabolic associated fatty liver disease and alcohol-related fatty liver disease. […] Metabolic associated fatty liver disease is caused by: being overweight or obese, not being active enough. […] Alcohol-related fatty liver disease is caused by drinking too much alcohol over long periods.

• #36 Fatty liver — symptoms, causes and treatment | healthdirect

  https://www.healthdirect.gov.au/fatty-liver

  Fatty liver is usually due to a combination of factors over a long period of time. […] The most common causes of fatty liver are: being obese or overweight especially around the abdomen (tummy), having type 2 diabetes mellitus or insulin resistance, having high blood cholesterol or high triglycerides, drinking too much alcohol. […] Less common causes are: an underactive thyroid, certain medicines, having polycystic ovary syndrome (PCOS). […] There are 2 main types of fatty liver disease: metabolic associated fatty liver disease and alcohol-related fatty liver disease. […] Metabolic associated fatty liver disease is caused by: being overweight or obese, not being active enough. […] Alcohol-related fatty liver disease is caused by drinking too much alcohol over long periods.

• #37 Liver – fatty liver disease | Better Health Channel

  https://www.betterhealth.vic.gov.au/health/conditionsandtreatments/liver-fatty-liver-disease

  Fatty liver disease is a build-up of fats in the liver that can damage the organ and lead to serious complications. […] Risk factors include obesity, a high-fat diet, high alcohol intake and diabetes mellitus. […] Eating excess calories causes fat to build up in the liver. When the liver does not process and break down fats as it normally should, too much fat will accumulate. People tend to develop fatty liver if they have certain other conditions, such as obesity, diabetes or high triglycerides. Alcohol abuse, rapid weight loss and malnutrition may also lead to fatty liver. […] Many researchers now believe that metabolic syndrome a cluster of disorders that increase the risk of diabetes, heart disease and stroke plays an important role in the development of fatty liver. […] Of these, insulin resistance may be the most important trigger of NASH.

• #38 Genetic Liver Diseases | Liver Disease

  https://health.ucdavis.edu/conditions/genetic-liver-diseases

  Genetic liver diseases include Wilson disease, hemochromatosis, and alpha-1 antitrypsin deficiency. […] Genetic liver diseases are due to variants in genes, sometimes called mutations, that result in an impairment of liver function. In Wilson disease, this results in the accumulation of copper in the liver. With hemochromatosis, the liver is filled with iron. Alpha-1 antitrypsin deficiency leads to protein accumulation in the liver, which causes damage. For these conditions, you must inherit a mutation from both parents.

• #39 Chronic Liver Disease – StatPearls – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK554597/

  Genetic Causes: Alpha-1 antitrypsin deficiency: This is the most common genetic cause of CLD among children. […] Autoimmune hepatitis is a rare disease in which there is the destruction of liver parenchyma by autoantibodies. […] Other Causes of Chronic Liver Disease: Drugs – amiodarone, isoniazid, methotrexate, phenytoin, nitrofurantoin. […] Chronic liver disease is one of the frequent causes of death, especially in the developing world. […] The treatment goal is to stop the progression of the disease and complications and require a multidisciplinary approach.

• #40 Genetic Liver Diseases | Liver Disease

  https://health.ucdavis.edu/conditions/genetic-liver-diseases

  Genetic liver diseases include Wilson disease, hemochromatosis, and alpha-1 antitrypsin deficiency. […] Genetic liver diseases are due to variants in genes, sometimes called mutations, that result in an impairment of liver function. In Wilson disease, this results in the accumulation of copper in the liver. With hemochromatosis, the liver is filled with iron. Alpha-1 antitrypsin deficiency leads to protein accumulation in the liver, which causes damage. For these conditions, you must inherit a mutation from both parents.

• #41 Liver Failure: Causes, Symptoms, Treatments, Tests & More

  https://www.webmd.com/fatty-liver-disease/digestive-diseases-liver-failure

  Nonalcoholic fatty liver disease (NAFLD): It often affects people who are overweight, obese, or have high cholesterol. […] Less common reasons for chronic liver failure include: Autoimmune hepatitis: In this type, your body’s immune system, not a virus, attacks your liver and causes inflammation. […] Primary sclerosing cholangitis: This disease slowly damages your bile ducts. It mostly affects young men. […] Hemochromatosis: This inherited disorder causes your body to absorb and store too much iron. It can build up in your liver and cause cirrhosis. […] Wilson’s disease: People with this rare inherited disease store too much copper in their brain and liver. […] Alpha-1 antitrypsin deficiency: This genetic condition can lead to lung or liver disease.

• #42 Rare Liver Diseases – Community Liver Alliance

  https://communityliveralliance.org/rare-liver-diseases/

  Alpha-1 antitrypsin deficiency (Alpha-1) is a hereditary genetic disorder which may lead to the development of lung and/or liver disease. It is the most common genetic cause of liver disease in children. Adults can also be affected by Alpha-1 and may develop lung conditions such as emphysema as well as liver problems. Fortunately, many persons diagnosed with Alpha-1 never develop any of the associated diseases. […] Autoimmune hepatitis is a disease in which the body’s own immune system attacks the liver and causes it to become inflamed. The disease is chronic, meaning it lasts many years. If untreated, it can lead to cirrhosis and liver failure. […] Hemochromatosis is one of the most common genetic disorders in the United States. It is an inherited condition in which the body absorbs and stores too much iron. The extra iron builds up in several organs, especially the liver, and can cause serious damage. Without treatment, the disease can cause these organs to fail. […] Wilson Disease is an inherited condition that causes the body to retain excess copper. The liver of a person who has Wilson Disease does not release copper into bile as it should. As the copper builds up in the liver, it begins to damage the organ.

• #43 Liver Failure: Causes, Symptoms, Treatments, Tests & More

  https://www.webmd.com/fatty-liver-disease/digestive-diseases-liver-failure

  Nonalcoholic fatty liver disease (NAFLD): It often affects people who are overweight, obese, or have high cholesterol. […] Less common reasons for chronic liver failure include: Autoimmune hepatitis: In this type, your body’s immune system, not a virus, attacks your liver and causes inflammation. […] Primary sclerosing cholangitis: This disease slowly damages your bile ducts. It mostly affects young men. […] Hemochromatosis: This inherited disorder causes your body to absorb and store too much iron. It can build up in your liver and cause cirrhosis. […] Wilson’s disease: People with this rare inherited disease store too much copper in their brain and liver. […] Alpha-1 antitrypsin deficiency: This genetic condition can lead to lung or liver disease.

• #44 Genetic Liver Diseases | Liver Disease

  https://health.ucdavis.edu/conditions/genetic-liver-diseases

  Genetic liver diseases include Wilson disease, hemochromatosis, and alpha-1 antitrypsin deficiency. […] Genetic liver diseases are due to variants in genes, sometimes called mutations, that result in an impairment of liver function. In Wilson disease, this results in the accumulation of copper in the liver. With hemochromatosis, the liver is filled with iron. Alpha-1 antitrypsin deficiency leads to protein accumulation in the liver, which causes damage. For these conditions, you must inherit a mutation from both parents.

• #45 Cirrhosis

  https://www.nhs.uk/conditions/cirrhosis/

  Cirrhosis is caused by long-term damage to your liver. […] You may be more likely to have cirrhosis if you: regularly drink a lot of alcohol (over 50 units of alcohol a week if you’re a man and over 35 units a week if you’re a woman) […] have hepatitis B or hepatitis C […] live with obesity […] have type 2 diabetes […] have non-alcoholic fatty liver disease (NAFLD) […] have an autoimmune liver condition, such as autoimmune hepatitis, primary biliary cholangitis or primary sclerosing cholangitis […] have a genetic condition, such as haemochromatosis, Wilson’s disease, alpha-1 antitrypsin deficiency or cystic fibrosis. […] How serious cirrhosis is depends on things like what’s causing it and how early it’s diagnosed and treated. […] This usually involves treating the cause, for example, antiviral medicines if it’s caused by hepatitis B or C.

• #46 Cirrhosis: Causes, symptoms, and treatments of liver scarring

  https://www.medicalnewstoday.com/articles/172295

  The liver breaks down toxins, including alcohol. But, if toxin levels are too high, the liver will be unable to process them effectively, and damage to liver cells will result. […] People who consume 30-50 grams (g) of alcohol per day for 5 years have a risk of alcohol-related liver disease. […] Doctors diagnose non-alcohol-related fatty liver disease (NAFLD) when fat accumulates in over 5% of liver cells, and there is no other explanation. […] Other diseases and conditions that can contribute to cirrhosis include: cystic fibrosis, primary sclerosing cholangitis, or hardening and scarring of the bile ducts, galactosemia, or inability to process sugars in milk, schistosomiasis, a parasitic disease, biliary atresia, which affects the formation of bile ducts before birth, glycogen storage disease, when the body has problems storing and releasing the energy release that is vital for cell function, hemochromatosis, when iron accumulates in the liver and other parts of the body, Budd-Chiari syndrome, when blood clots in the hepatic vein lead to liver enlargement and the development of new blood vessels, cancer of the bile ducts or pancreas, which can lead to blockages in the bile ducts. […] Possible causes include a hepatitis infection, high consumption of alcohol, some genetic conditions, and inflammation that occurs with obesity and metabolic disorder.

• #47 Chronic Liver Disease/Cirrhosis | Cedars-Sinai

  https://www.cedars-sinai.org/health-library/diseases-and-conditions/c/chronic-liver-diseasecirrhosis.html

  Cirrhosis is a long-term (chronic) liver disease. […] The most common causes of cirrhosis are: Hepatitis and other viruses. Long-term alcohol abuse. Metabolic dysfunction-associated steatotic liver disease. (This happens from metabolic syndrome and is caused by conditions such as obesity, diabetes, high cholesterol and triglycerides, and high blood pressure.) […] Other less common causes of cirrhosis may include: Autoimmune disorders, where the body’s infection-fighting system (immune system) attacks healthy tissue. Blocked or damaged tubes (bile ducts) that carry bile from the liver to the intestine. Use of certain medicines. Exposure to certain toxic chemicals. Repeated episodes of heart failure with blood buildup in the liver. Parasite infections. […] Some diseases passed from parent to child (inherited diseases) may also cause cirrhosis. These may include: Alpha1-antitrypsin deficiency. High blood galactose levels. Glycogen storage diseases. Cystic fibrosis. Porphyria (a disorder in which certain chemicals build up in the blood). Hereditary buildup of too much copper (Wilson disease) or iron (hemochromatosis) in the body. […] The most common causes are hepatitis and other viruses, and alcohol abuse. Other medical problems can also cause it.

• #48 Liver Diseases: Liver Problems Types, Symptoms & Causes

  https://liverfoundation.org/liver-diseases/

  Alcohol-related liver disease is caused by excessive consumption of alcohol and is a common, but preventable, disease. […] An autoimmune liver disease develops when your own immune system mistakes normal, healthy tissue for a foreign body. […] Viral hepatitis is liver inflammation due to a viral infection.

• #49 Cirrhosis: Causes, symptoms, and treatments of liver scarring

  https://www.medicalnewstoday.com/articles/172295

  Cirrhosis is a progressive condition where scar tissue gradually replaces healthy liver cells. […] Various factors can lead to liver damage and cirrhosis, such as: viral infections, alcohol consumption, toxins, including medications, hereditary and genetic conditions, some autoimmune diseases, metabolic syndrome, including obesity, which leads to widespread inflammation. […] Common causes of cirrhosis are: hepatitis, a viral infection; long-term high alcohol consumption; non-alcohol-related steatosis, a type of fatty liver disease; exposure to toxins; genetic diseases. […] Globally, hepatitis B and C are the leading causes of cirrhosis. […] In autoimmune hepatitis, the person has an autoimmune disease. In this type of disease, the immune system mistakenly attacks healthy cells. Sometimes, an autoimmune disease can affect the liver, leading to hepatitis and cirrhosis.

• #50 What Causes Liver Damage & Disease? | Hep C & Liver Health | Hepatitis NSW

  https://www.hep.org.au/liver-health/what-causes-liver-damage-and-disease/

  Autoimmune Hepatitis (AIH) is when a persons own immune system attacks their liver. The immune system damages the liver cells. AIH is a lifelong illness, which can be treated with medication. If left untreated, AIH can lead to fibrosis and cirrhosis, and some people may need a liver transplant. […] Lifestyle and diet play a big role in your liver health. Too many saturated fats, salts and processed sugars can make it harder for the liver to work as it should, which can lead to inflammation and even scarring. […] There are some high risk lifestyle factors that may lead to liver damage or disease. Heavy drinking, obesity, diabetes and high cholesterol can all affect your liver health.

• #51 Understanding liver disease in women | Northwell Health

  https://www.northwell.edu/katz-institute-for-womens-health/articles/liver-disease

  Liver is the only organ that can repair itself but various diseases can cause reversible and irreversible damage. Approximately 5.5 million Americans are currently living with chronic liver disease, and up to 30% of adults have excessive fat in their liver which could lead to more serious liver disease (source: American Liver Foundation). There are more than 100 different liver diseases with some more common in women, including: […] Alcoholic liver disease is more common in women because women absorb more alcohol relative to their body size than men. As little as two drinks a day may be enough to cause this condition. […] Approximately 80 percent of patients diagnosed with autoimmune hepatitis are women. […] Non-alcoholic fatty liver disease affects 60 to 80 million Americans. Excessive fat can be toxic to the liver and cause inflammation. It is the leading cause of cirrhosis in the US with risk factors that include diabetes and obesity.

• #52 Understanding liver disease in women | Northwell Health

  https://www.northwell.edu/katz-institute-for-womens-health/articles/liver-disease

  Diagnosed almost exclusively in women, this chronic condition causes bile ducts in the liver to slowly be destroyed. […] Benign liver tumors are more common in women. Certain types have been linked to oral contraceptive use where higher doses of estrogen were used. […] Cirrhosis is a consequence of any chronic liver disease and can lead to such complications as hepatic encephalopathy, esophageal varices, abdominal ascites, liver failure and liver cancer. […] Liver disease is common in women, and it is widely underdiagnosed, says Dr. David Bernstein, chief, Division of Hepatology at Northwell Health. By keeping alcohol intake low, maintaining a healthy diet and exercising regularly, women can significantly reduce their chance of developing some of the most common types of liver disease.

• #53 Liver Failure: Causes, Symptoms, Treatments, Tests & More

  https://www.webmd.com/fatty-liver-disease/digestive-diseases-liver-failure

  Nonalcoholic fatty liver disease (NAFLD): It often affects people who are overweight, obese, or have high cholesterol. […] Less common reasons for chronic liver failure include: Autoimmune hepatitis: In this type, your body’s immune system, not a virus, attacks your liver and causes inflammation. […] Primary sclerosing cholangitis: This disease slowly damages your bile ducts. It mostly affects young men. […] Hemochromatosis: This inherited disorder causes your body to absorb and store too much iron. It can build up in your liver and cause cirrhosis. […] Wilson’s disease: People with this rare inherited disease store too much copper in their brain and liver. […] Alpha-1 antitrypsin deficiency: This genetic condition can lead to lung or liver disease.

• #54 Causes of Liver Disease | Springer Publishing

  https://connect.springerpub.com/content/book/978-0-8261-1749-6/part/part03/chapter/ch16

  This chapter focuses on the causes of liver disease, including alpha-1 antitrypsin deficiency, Budd-Chiari syndrome (BCS), hereditary hemochromatosis (HH), primary sclerosing cholangitis (PSC), primary biliary cirrhosis (PBC), polycystic liver disease, and Wilsons disease. […] Vascular disorders of the liver include congenital vascular malformations, portal vein thrombosis, sinusoidal obstruction syndrome, and BCS. […] PBC is an autoimmune disorder that affects the bile ducts. […] A serologic marker that is highly suggestive of PBC is antimitochondrial antibody (AMA). […] BCS should be considered in patients with abdominal pain, hepatomegaly, ascites, or with known risk factors of thrombosis. […] Ultrasonography is performed to evaluate the hepatic vasculature for thrombosis or blood-flow issues.

• #55 Liver Disease: Signs & Symptoms, Causes, Stages, Treatment

  https://my.clevelandclinic.org/health/diseases/17179-liver-disease

  When healthcare providers refer to liver disease, theyre usually referring to chronic conditions that do progressive damage to your liver over time. Viral infections, toxic poisoning and certain metabolic conditions are among the common causes of chronic liver disease. […] There are over 100 types of liver disease, but they fall into a handful of subtypes. Causes include: Viral infections. Viral hepatitis infections that become chronic can cause chronic hepatitis, including hepatitis B and hepatitis C. Alcohol-induced hepatitis. Heavy alcohol use can cause acute or chronic hepatitis. If it goes on long enough, it can cause cirrhosis and liver failure. Toxic hepatitis. Chronic overexposure to toxins, such as industrial chemicals or drugs, can cause acute or chronic hepatitis. Non-alcohol related fatty liver disease. Metabolic conditions associated with obesity, high blood sugar and high blood lipids can cause excess fat storage in your liver, which can cause inflammation (non-alcohol related steatohepatitis). Biliary stasis. Congenital (present at birth) conditions that obstruct or stall the flow of bile through your bile ducts can cause bile to build up and injure your liver, including biliary atresia and cystic fibrosis. Non-congenital causes include biliary stricture and gallstones. Autoimmune diseases. Autoimmune conditions can cause chronic inflammation and scarring in your liver or your bile ducts, including autoimmune hepatitis, primary biliary cholangitis and primary sclerosing cholangitis. Inherited metabolic disorders. Disorders that cause toxic products to build up in your blood such as glycogen storage disease (GSD), Wilson disease, hemochromatosis and Gaucher disease can cause chronic liver damage. Cardiovascular diseases. Conditions that affect blood flow to and from your liver including Budd-Chiari syndrome, ischemia, arterial diseases and right-sided heart failure can cause chronic liver damage.

• #56 Liver diseases: epidemiology, causes, trends and predictions | Signal Transduction and Targeted Therapy

  https://www.nature.com/articles/s41392-024-02072-z

  As a highly complex organ with digestive, endocrine, and immune-regulatory functions, the liver is pivotal in maintaining physiological homeostasis through its roles in metabolism, detoxification, and immune response. Various factors including viruses, alcohol, metabolites, toxins, and other pathogenic agents can compromise liver function, leading to acute or chronic injury that may progress to end-stage liver diseases. […] Liver diseases represent a wide array of disorders characterized by hepatocyte injury, inflammatory cell infiltration, and HSC activation, which cumulatively impair liver function and disrupt its architecture. […] Acute liver diseases often result from hepatotropic virus infections, though drug-induced liver injury (DILI) is also becoming increasingly prevalent worldwide. Chronic liver conditions, on the other hand, typically arise from factors like alcohol consumption, hepatitis B virus (HBV), and hepatitis C virus (HCV) infections, along with a rising incidence of metabolic dysfunction-associated steatotic liver disease (MASLD) globally.

• #57 Chronic Liver Disease – StatPearls – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK554597/

  Genetic Causes: Alpha-1 antitrypsin deficiency: This is the most common genetic cause of CLD among children. […] Autoimmune hepatitis is a rare disease in which there is the destruction of liver parenchyma by autoantibodies. […] Other Causes of Chronic Liver Disease: Drugs – amiodarone, isoniazid, methotrexate, phenytoin, nitrofurantoin. […] Chronic liver disease is one of the frequent causes of death, especially in the developing world. […] The treatment goal is to stop the progression of the disease and complications and require a multidisciplinary approach.

• #58 Acute liver failure – Symptoms and causes – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/acute-liver-failure/symptoms-causes/syc-20352863

  Acute liver failure occurs when liver cells are seriously damaged and are no longer able to function. Possible causes include: […] Taking too much acetaminophen (Tylenol, others) is the most common cause of acute liver failure in the United States. […] Hepatitis A, hepatitis B and hepatitis E increase the risk of acute liver failure. Other viruses that can increase risk include Epstein-Barr virus, cytomegalovirus and herpes simplex virus. […] Some prescription medicines, including antibiotics, nonsteroidal anti-inflammatory drugs and anticonvulsants, can cause acute liver failure. […] Herbal drugs and supplements, including kava, ephedra, skullcap and pennyroyal, have been linked to acute liver failure. […] Toxins that can cause acute liver failure include the poisonous wild mushroom Amanita phalloides, which is sometimes mistaken for one that is safe to eat.

• #59 Liver Disease: Causes and Risk Factors

  https://www.verywellhealth.com/liver-disease-causes-and-risk-factors-6260092

  Lifestyle factors play a large role in liver disease. The following lifestyle risk factors can become causes of liver disease, especially if youre already genetically predisposed to liver disease. […] The liver breaks down alcohol. But when you drink more than it can process, alcohol begins to damage the liver. This leads to fatty liver disease, where fat builds up in the liver, causing it to become inflamed. Eventually, fatty liver disease can lead to cirrhosis. In fact, alcohol use is the leading cause of cirrhosis. […] Just four drinks a day for males and two drinks a day for females can increase your risk of liver disease. […] But when youre exposed to high levels of toxins like pesticides, they can damage your liver and cause liver disease. […] While most people who take supplements do so in hopes of improving their health, taking too many supplements can increase your risk of liver disease. Up to 20% of liver injuries are caused by supplements, so dont think youre in the clear just because what youre taking is all natural.

• #60 Causes, Risk Factors and Treatment of Liver Disease – CyberKnife Miami

  https://www.cyberknifemiami.com/causes-risk-factors-and-treatment-of-liver-disease/

  Genetics are a risk factor even for liver diseases that have environmental causes. For example, researchers believe that some heavy drinkers are genetically predisposed to liver disease, while others are not. […] The liver breaks down alcohol. But when you drink more than it can process, alcohol begins to damage the liver. This leads to fatty liver disease, where fat builds up in the liver, causing it to become inflamed. Eventually, fatty liver disease can lead to cirrhosis. In fact, alcohol use is the leading cause of cirrhosis. […] Alcohol use can cause liver diseases including: Alcoholic hepatitis: inflammation of the liver, Cirrhosis: scarring of the liver, Liver cancer. […] Just like the liver has to clear away alcohol, it clears away other toxins from your body. But when youre exposed to high levels of toxins like pesticides, they can damage your liver and cause liver disease.

• #61 Liver Disease: Signs & Symptoms, Causes, Stages, Treatment

  https://my.clevelandclinic.org/health/diseases/17179-liver-disease

  When healthcare providers refer to liver disease, theyre usually referring to chronic conditions that do progressive damage to your liver over time. Viral infections, toxic poisoning and certain metabolic conditions are among the common causes of chronic liver disease. […] There are over 100 types of liver disease, but they fall into a handful of subtypes. Causes include: Viral infections. Viral hepatitis infections that become chronic can cause chronic hepatitis, including hepatitis B and hepatitis C. Alcohol-induced hepatitis. Heavy alcohol use can cause acute or chronic hepatitis. If it goes on long enough, it can cause cirrhosis and liver failure. Toxic hepatitis. Chronic overexposure to toxins, such as industrial chemicals or drugs, can cause acute or chronic hepatitis. Non-alcohol related fatty liver disease. Metabolic conditions associated with obesity, high blood sugar and high blood lipids can cause excess fat storage in your liver, which can cause inflammation (non-alcohol related steatohepatitis). Biliary stasis. Congenital (present at birth) conditions that obstruct or stall the flow of bile through your bile ducts can cause bile to build up and injure your liver, including biliary atresia and cystic fibrosis. Non-congenital causes include biliary stricture and gallstones. Autoimmune diseases. Autoimmune conditions can cause chronic inflammation and scarring in your liver or your bile ducts, including autoimmune hepatitis, primary biliary cholangitis and primary sclerosing cholangitis. Inherited metabolic disorders. Disorders that cause toxic products to build up in your blood such as glycogen storage disease (GSD), Wilson disease, hemochromatosis and Gaucher disease can cause chronic liver damage. Cardiovascular diseases. Conditions that affect blood flow to and from your liver including Budd-Chiari syndrome, ischemia, arterial diseases and right-sided heart failure can cause chronic liver damage.

• #62 Acute liver failure – Symptoms and causes – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/acute-liver-failure/symptoms-causes/syc-20352863

  Liver failure can be caused by autoimmune hepatitis a disease in which the immune system attacks liver cells, causing inflammation and injury. […] Vascular diseases, such as Budd-Chiari syndrome, can cause blockages in the veins of the liver and lead to acute liver failure. […] Rare metabolic diseases, such as Wilson’s disease and acute fatty liver of pregnancy, sometimes cause acute liver failure. […] Cancer that either begins in or spreads to the liver can cause the liver to fail. […] Overwhelming infection, called sepsis, and shock can severely reduce blood flow to the liver, causing liver failure. […] Extreme physical activity in a hot environment can trigger acute liver failure. […] Some cases of acute liver failure have no obvious cause.

• #63 Cirrhosis: Causes, symptoms, and treatments of liver scarring

  https://www.medicalnewstoday.com/articles/172295

  The liver breaks down toxins, including alcohol. But, if toxin levels are too high, the liver will be unable to process them effectively, and damage to liver cells will result. […] People who consume 30-50 grams (g) of alcohol per day for 5 years have a risk of alcohol-related liver disease. […] Doctors diagnose non-alcohol-related fatty liver disease (NAFLD) when fat accumulates in over 5% of liver cells, and there is no other explanation. […] Other diseases and conditions that can contribute to cirrhosis include: cystic fibrosis, primary sclerosing cholangitis, or hardening and scarring of the bile ducts, galactosemia, or inability to process sugars in milk, schistosomiasis, a parasitic disease, biliary atresia, which affects the formation of bile ducts before birth, glycogen storage disease, when the body has problems storing and releasing the energy release that is vital for cell function, hemochromatosis, when iron accumulates in the liver and other parts of the body, Budd-Chiari syndrome, when blood clots in the hepatic vein lead to liver enlargement and the development of new blood vessels, cancer of the bile ducts or pancreas, which can lead to blockages in the bile ducts. […] Possible causes include a hepatitis infection, high consumption of alcohol, some genetic conditions, and inflammation that occurs with obesity and metabolic disorder.

• #64 Liver Disease: Signs & Symptoms, Causes, Stages, Treatment

  https://my.clevelandclinic.org/health/diseases/17179-liver-disease

  When healthcare providers refer to liver disease, theyre usually referring to chronic conditions that do progressive damage to your liver over time. Viral infections, toxic poisoning and certain metabolic conditions are among the common causes of chronic liver disease. […] There are over 100 types of liver disease, but they fall into a handful of subtypes. Causes include: Viral infections. Viral hepatitis infections that become chronic can cause chronic hepatitis, including hepatitis B and hepatitis C. Alcohol-induced hepatitis. Heavy alcohol use can cause acute or chronic hepatitis. If it goes on long enough, it can cause cirrhosis and liver failure. Toxic hepatitis. Chronic overexposure to toxins, such as industrial chemicals or drugs, can cause acute or chronic hepatitis. Non-alcohol related fatty liver disease. Metabolic conditions associated with obesity, high blood sugar and high blood lipids can cause excess fat storage in your liver, which can cause inflammation (non-alcohol related steatohepatitis). Biliary stasis. Congenital (present at birth) conditions that obstruct or stall the flow of bile through your bile ducts can cause bile to build up and injure your liver, including biliary atresia and cystic fibrosis. Non-congenital causes include biliary stricture and gallstones. Autoimmune diseases. Autoimmune conditions can cause chronic inflammation and scarring in your liver or your bile ducts, including autoimmune hepatitis, primary biliary cholangitis and primary sclerosing cholangitis. Inherited metabolic disorders. Disorders that cause toxic products to build up in your blood such as glycogen storage disease (GSD), Wilson disease, hemochromatosis and Gaucher disease can cause chronic liver damage. Cardiovascular diseases. Conditions that affect blood flow to and from your liver including Budd-Chiari syndrome, ischemia, arterial diseases and right-sided heart failure can cause chronic liver damage.

• #65 Liver Disease: Signs & Symptoms, Causes, Stages, Treatment

  https://my.clevelandclinic.org/health/diseases/17179-liver-disease

  When healthcare providers refer to liver disease, theyre usually referring to chronic conditions that do progressive damage to your liver over time. Viral infections, toxic poisoning and certain metabolic conditions are among the common causes of chronic liver disease. […] There are over 100 types of liver disease, but they fall into a handful of subtypes. Causes include: Viral infections. Viral hepatitis infections that become chronic can cause chronic hepatitis, including hepatitis B and hepatitis C. Alcohol-induced hepatitis. Heavy alcohol use can cause acute or chronic hepatitis. If it goes on long enough, it can cause cirrhosis and liver failure. Toxic hepatitis. Chronic overexposure to toxins, such as industrial chemicals or drugs, can cause acute or chronic hepatitis. Non-alcohol related fatty liver disease. Metabolic conditions associated with obesity, high blood sugar and high blood lipids can cause excess fat storage in your liver, which can cause inflammation (non-alcohol related steatohepatitis). Biliary stasis. Congenital (present at birth) conditions that obstruct or stall the flow of bile through your bile ducts can cause bile to build up and injure your liver, including biliary atresia and cystic fibrosis. Non-congenital causes include biliary stricture and gallstones. Autoimmune diseases. Autoimmune conditions can cause chronic inflammation and scarring in your liver or your bile ducts, including autoimmune hepatitis, primary biliary cholangitis and primary sclerosing cholangitis. Inherited metabolic disorders. Disorders that cause toxic products to build up in your blood such as glycogen storage disease (GSD), Wilson disease, hemochromatosis and Gaucher disease can cause chronic liver damage. Cardiovascular diseases. Conditions that affect blood flow to and from your liver including Budd-Chiari syndrome, ischemia, arterial diseases and right-sided heart failure can cause chronic liver damage.

• #66 Liver Disease: Signs & Symptoms, Causes, Stages, Treatment

  https://my.clevelandclinic.org/health/diseases/17179-liver-disease

  When healthcare providers refer to liver disease, theyre usually referring to chronic conditions that do progressive damage to your liver over time. Viral infections, toxic poisoning and certain metabolic conditions are among the common causes of chronic liver disease. […] There are over 100 types of liver disease, but they fall into a handful of subtypes. Causes include: Viral infections. Viral hepatitis infections that become chronic can cause chronic hepatitis, including hepatitis B and hepatitis C. Alcohol-induced hepatitis. Heavy alcohol use can cause acute or chronic hepatitis. If it goes on long enough, it can cause cirrhosis and liver failure. Toxic hepatitis. Chronic overexposure to toxins, such as industrial chemicals or drugs, can cause acute or chronic hepatitis. Non-alcohol related fatty liver disease. Metabolic conditions associated with obesity, high blood sugar and high blood lipids can cause excess fat storage in your liver, which can cause inflammation (non-alcohol related steatohepatitis). Biliary stasis. Congenital (present at birth) conditions that obstruct or stall the flow of bile through your bile ducts can cause bile to build up and injure your liver, including biliary atresia and cystic fibrosis. Non-congenital causes include biliary stricture and gallstones. Autoimmune diseases. Autoimmune conditions can cause chronic inflammation and scarring in your liver or your bile ducts, including autoimmune hepatitis, primary biliary cholangitis and primary sclerosing cholangitis. Inherited metabolic disorders. Disorders that cause toxic products to build up in your blood such as glycogen storage disease (GSD), Wilson disease, hemochromatosis and Gaucher disease can cause chronic liver damage. Cardiovascular diseases. Conditions that affect blood flow to and from your liver including Budd-Chiari syndrome, ischemia, arterial diseases and right-sided heart failure can cause chronic liver damage.

• #67 Liver Disease: Early Signs, Chronic Symptoms, Damage & Treatment

  https://www.medicinenet.com/liver_disease/article.htm

  Hemochromatosis is a metabolic disorder that leads to abnormally elevated iron stores in the body. […] Wilson’s disease is another inherited disease that affects the body’s ability to metabolize copper. […] Primary cancers of the liver arise from liver structures and cells. […] Blood flow abnormalities can cause liver cells to die and lead to cirrhosis and liver failure. […] Alcohol abuse is the most common cause of liver disease in North America. […] Hepatitis B and C can be decreased by minimizing the risk of exposure to another person’s bodily fluids. […] Fatty liver disease is a preventable illness with the promotion of a healthy lifestyle.

• #68 What Causes Liver Damage & Disease? | Hep C & Liver Health | Hepatitis NSW

  https://www.hep.org.au/liver-health/what-causes-liver-damage-and-disease/

  Autoimmune Hepatitis (AIH) is when a persons own immune system attacks their liver. The immune system damages the liver cells. AIH is a lifelong illness, which can be treated with medication. If left untreated, AIH can lead to fibrosis and cirrhosis, and some people may need a liver transplant. […] Lifestyle and diet play a big role in your liver health. Too many saturated fats, salts and processed sugars can make it harder for the liver to work as it should, which can lead to inflammation and even scarring. […] There are some high risk lifestyle factors that may lead to liver damage or disease. Heavy drinking, obesity, diabetes and high cholesterol can all affect your liver health.

• #69 9 Things That Can Cause Cirrhosis of the Liver

  https://www.health.com/condition/hepatitis-c/what-causes-cirrhosis-liver

  You may think alcohol is the only culprit, but many factors can lead to cirrhosis or liver damage. […] Scarring (cirrhosis) can occur if the liver becomes damaged, which can eventually cause liver failure or cancer. […] Other conditions include liver cancer, Wilson disease, and damage caused by alcohol. […] Several health conditions can directly cause or increase the risk of liver damage. Some of these health conditions include obesity, hepatitis, genetic diseases, and various autoimmune conditions. […] Obesity is thought to play a role in nonalcoholic fatty liver disease (NAFLD), which affects about 100 million people in the United States and „will soon be the number-one reason for liver transplantation in the U.S.” […] Chronic hepatitis B and C are responsible for most cases of liver cancer worldwide.

• #70 Acute liver failure – Symptoms and causes – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/acute-liver-failure/symptoms-causes/syc-20352863

  Liver failure can be caused by autoimmune hepatitis a disease in which the immune system attacks liver cells, causing inflammation and injury. […] Vascular diseases, such as Budd-Chiari syndrome, can cause blockages in the veins of the liver and lead to acute liver failure. […] Rare metabolic diseases, such as Wilson’s disease and acute fatty liver of pregnancy, sometimes cause acute liver failure. […] Cancer that either begins in or spreads to the liver can cause the liver to fail. […] Overwhelming infection, called sepsis, and shock can severely reduce blood flow to the liver, causing liver failure. […] Extreme physical activity in a hot environment can trigger acute liver failure. […] Some cases of acute liver failure have no obvious cause.

• #71 10 Reasons that cause Liver Disease

  https://www.kauveryhospital.com/blog/gastroenterology/10-reasons-that-cause-liver-disease/

  Given the enormity of functions that the liver is responsible for, the possibility of health issues arising is numerous, thereby giving reasons for liver damage. […] Additionally, there are 9 other reasons why liver damage occurs. They include: […] The risk of liver disease occurring in diabetic patients is 50%. […] High intake of salt causes a buildup of fluids in the liver, causing it to swell and consequently cause fatty liver disease. […] Adulterated foods, fruits, and vegetables containing pesticides and heavy metals cause damage to the liver, as the toxins in the chemicals get stored in the liver over a lifetime. […] Excessive consumption of alcohol is the commonest cause of liver damage. […] Overproduction of the yeast Candida interferes with the detoxification functions of the liver, consequently causing damage.

• #72 Acute liver failure – Symptoms and causes – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/acute-liver-failure/symptoms-causes/syc-20352863

  Liver failure can be caused by autoimmune hepatitis a disease in which the immune system attacks liver cells, causing inflammation and injury. […] Vascular diseases, such as Budd-Chiari syndrome, can cause blockages in the veins of the liver and lead to acute liver failure. […] Rare metabolic diseases, such as Wilson’s disease and acute fatty liver of pregnancy, sometimes cause acute liver failure. […] Cancer that either begins in or spreads to the liver can cause the liver to fail. […] Overwhelming infection, called sepsis, and shock can severely reduce blood flow to the liver, causing liver failure. […] Extreme physical activity in a hot environment can trigger acute liver failure. […] Some cases of acute liver failure have no obvious cause.

• #73 Acute liver failure – Symptoms and causes – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/acute-liver-failure/symptoms-causes/syc-20352863

  Liver failure can be caused by autoimmune hepatitis a disease in which the immune system attacks liver cells, causing inflammation and injury. […] Vascular diseases, such as Budd-Chiari syndrome, can cause blockages in the veins of the liver and lead to acute liver failure. […] Rare metabolic diseases, such as Wilson’s disease and acute fatty liver of pregnancy, sometimes cause acute liver failure. […] Cancer that either begins in or spreads to the liver can cause the liver to fail. […] Overwhelming infection, called sepsis, and shock can severely reduce blood flow to the liver, causing liver failure. […] Extreme physical activity in a hot environment can trigger acute liver failure. […] Some cases of acute liver failure have no obvious cause.

• #74 10 Reasons that cause Liver Disease

  https://www.kauveryhospital.com/blog/gastroenterology/10-reasons-that-cause-liver-disease/

  Given the enormity of functions that the liver is responsible for, the possibility of health issues arising is numerous, thereby giving reasons for liver damage. […] Additionally, there are 9 other reasons why liver damage occurs. They include: […] The risk of liver disease occurring in diabetic patients is 50%. […] High intake of salt causes a buildup of fluids in the liver, causing it to swell and consequently cause fatty liver disease. […] Adulterated foods, fruits, and vegetables containing pesticides and heavy metals cause damage to the liver, as the toxins in the chemicals get stored in the liver over a lifetime. […] Excessive consumption of alcohol is the commonest cause of liver damage. […] Overproduction of the yeast Candida interferes with the detoxification functions of the liver, consequently causing damage.

• #75 Acute liver failure – Symptoms and causes – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/acute-liver-failure/symptoms-causes/syc-20352863

  Liver failure can be caused by autoimmune hepatitis a disease in which the immune system attacks liver cells, causing inflammation and injury. […] Vascular diseases, such as Budd-Chiari syndrome, can cause blockages in the veins of the liver and lead to acute liver failure. […] Rare metabolic diseases, such as Wilson’s disease and acute fatty liver of pregnancy, sometimes cause acute liver failure. […] Cancer that either begins in or spreads to the liver can cause the liver to fail. […] Overwhelming infection, called sepsis, and shock can severely reduce blood flow to the liver, causing liver failure. […] Extreme physical activity in a hot environment can trigger acute liver failure. […] Some cases of acute liver failure have no obvious cause.

• #76 Risks and causes for liver cancer | Cancer Research UK

  https://www.cancerresearchuk.org/about-cancer/liver-cancer/risks-causes

  There is some evidence that people who chew betel quid have an increased risk of liver cancer. […] People may have an increased risk of liver cancer if they have had gallstones before, or had their gallbladder removed (cholecystectomy). […] There is evidence that exposure to the chemical vinyl chloride increases liver cancer risk. […] People with a family history of liver cancer may have an increased risk of developing it themselves. […] Liver flukes are infections caused by parasites. These infections can increase your risk of liver cancer.

• #77 Risks and causes for liver cancer | Cancer Research UK

  https://www.cancerresearchuk.org/about-cancer/liver-cancer/risks-causes

  Heavy alcohol use increases your risk of liver cancer. Drinking alcohol long term can cause cirrhosis of the liver. Cirrhosis in turn increases the risk of liver cancer. Alcohol might also directly damage the DNA inside liver cells. […] Having non alcoholic fatty liver disease increases your risk of liver cancer. […] Long term infection with the hepatitis B or C virus increases the risk of developing primary liver cancer. This is mainly because these viruses cause damage to the liver (cirrhosis). […] People with diabetes have a higher risk of liver cancer than people who do not have diabetes. […] Studies have shown that people with HIV or AIDS have an increased risk of liver cancer. […] Aflatoxin is a substance found in foods such as mouldy peanuts, wheat, soya beans, groundnuts, corn, rice. People from Africa and Asia who have eaten these over a long period of time have an increased risk of developing liver cancer.

• #78 Liver Disease: Types of Liver Problems, Causes, and More

  https://www.healthline.com/health/liver-diseases

  Chronic liver failure typically happens when a significant part of your liver is damaged and cant function properly. […] Certain things can make you more likely to develop certain liver diseases. One of the most well-known risk factors is heavy drinking, which the Centers for Disease Control and Prevention (CDC) defines as more than 8 alcoholic drinks per week for women and more than 15 drinks per week for men. […] While not all liver disease or damage can be prevented, lifestyle choices can make a big difference when it comes to keeping your liver healthy. […] Many liver diseases are chronic, meaning they last for years and may never go away. But even chronic liver diseases can usually be managed. […] The complications of untreated or unmanaged liver disease can lead to cirrhosis, severe scarring that cannot be reversed. If cirrhosis has gone too far, a liver transplant may be your only option.

• #79 Liver Disease: Causes and Risk Factors

  https://www.verywellhealth.com/liver-disease-causes-and-risk-factors-6260092

  There are many different types of liver disease, including cirrhosis, hepatitis, and cancer. The causes include genetic risk factors; exposure to toxins, including drugs and alcohol; and other health factors. […] If you have a parent or sibling who has genetic liver disease, talk to your healthcare provider. You may want to avoid alcohol and get an annual liver enzyme test to check the health of your liver. […] Hereditary hemochromatosis is a condition that causes the body to build up too much iron, which is toxic to the liver. […] Wilson’s disease is a genetic condition that causes copper to build up in the body. That in turn can lead to liver diseases like hepatitis and cirrhosis. […] Alpha-1-antitrypsin deficiency, or AAT deficiency, occurs when people dont have an important protein. The absence of the protein can affect liver function and lead to liver disease as well as lung diseases including emphysema.

• #80 Causes, Risk Factors and Treatment of Liver Disease – CyberKnife Miami

  https://www.cyberknifemiami.com/causes-risk-factors-and-treatment-of-liver-disease/

  There are many different types of liver disease, including cirrhosis, hepatitis, and cancer. The causes include genetic risk factors; exposure to toxins, including drugs and alcohol; and other health factors. […] Scientists are still working to understand exactly how genes play a role in liver disease. However, it seems that genetics explain why some people develop liver disease and other people dont, even when they have or dont have other risk factors. […] Hereditary hemochromatosis is a condition that causes the body to build up too much iron, which is toxic to the liver. Hemochromatosis is linked to changes in the HFE gene. […] Wilsons disease is a genetic condition that causes copper to build up in the body. That in turn can lead to liver diseases like hepatitis and cirrhosis. […] Alpha-1-antitrypsin deficiency, or AAT deficiency, occurs when people dont have an important protein. The absence of the protein can affect liver function and lead to liver disease as well as lung diseases including emphysema.

• #81 Causes, Risk Factors and Treatment of Liver Disease – CyberKnife Miami

  https://www.cyberknifemiami.com/causes-risk-factors-and-treatment-of-liver-disease/

  Genetics are a risk factor even for liver diseases that have environmental causes. For example, researchers believe that some heavy drinkers are genetically predisposed to liver disease, while others are not. […] The liver breaks down alcohol. But when you drink more than it can process, alcohol begins to damage the liver. This leads to fatty liver disease, where fat builds up in the liver, causing it to become inflamed. Eventually, fatty liver disease can lead to cirrhosis. In fact, alcohol use is the leading cause of cirrhosis. […] Alcohol use can cause liver diseases including: Alcoholic hepatitis: inflammation of the liver, Cirrhosis: scarring of the liver, Liver cancer. […] Just like the liver has to clear away alcohol, it clears away other toxins from your body. But when youre exposed to high levels of toxins like pesticides, they can damage your liver and cause liver disease.

• #82 Alcoholic liver disease: Symptoms, treatment, and causes

  https://www.medicalnewstoday.com/articles/215638

  Females are more susceptible to the negative effects of alcohol, even at the same levels of alcohol intake as males, so are more likely to quickly develop fibrosis, inflammation, and liver injury as a result of alcohol. […] Having hepatitis C increases the risk, and a person who consumes alcohol regularly and has had any type of hepatitis faces a higher chance of developing liver disease. […] Genetic changes can affect the risk. If a person experiences changes in the genetic profiles of particular enzymes that are key to alcohol metabolisms, such as ADH, ALDH, and CYP4502E1, they will have a higher chance of developing alcoholic liver disease.

• #83 Liver Disease: Causes and Risk Factors

  https://www.verywellhealth.com/liver-disease-causes-and-risk-factors-6260092

  Lifestyle factors play a large role in liver disease. The following lifestyle risk factors can become causes of liver disease, especially if youre already genetically predisposed to liver disease. […] The liver breaks down alcohol. But when you drink more than it can process, alcohol begins to damage the liver. This leads to fatty liver disease, where fat builds up in the liver, causing it to become inflamed. Eventually, fatty liver disease can lead to cirrhosis. In fact, alcohol use is the leading cause of cirrhosis. […] Just four drinks a day for males and two drinks a day for females can increase your risk of liver disease. […] But when youre exposed to high levels of toxins like pesticides, they can damage your liver and cause liver disease. […] While most people who take supplements do so in hopes of improving their health, taking too many supplements can increase your risk of liver disease. Up to 20% of liver injuries are caused by supplements, so dont think youre in the clear just because what youre taking is all natural.

• #84 Cirrhosis

  https://www.nhs.uk/conditions/cirrhosis/

  Cirrhosis is caused by long-term damage to your liver. […] You may be more likely to have cirrhosis if you: regularly drink a lot of alcohol (over 50 units of alcohol a week if you’re a man and over 35 units a week if you’re a woman) […] have hepatitis B or hepatitis C […] live with obesity […] have type 2 diabetes […] have non-alcoholic fatty liver disease (NAFLD) […] have an autoimmune liver condition, such as autoimmune hepatitis, primary biliary cholangitis or primary sclerosing cholangitis […] have a genetic condition, such as haemochromatosis, Wilson’s disease, alpha-1 antitrypsin deficiency or cystic fibrosis. […] How serious cirrhosis is depends on things like what’s causing it and how early it’s diagnosed and treated. […] This usually involves treating the cause, for example, antiviral medicines if it’s caused by hepatitis B or C.

• #85 Liver Disease: Causes and Risk Factors

  https://www.verywellhealth.com/liver-disease-causes-and-risk-factors-6260092

  Having an unhealthy weight can increase your risk for health conditions, including diabetes and high cholesterol. These in turn increase your risk of nonalcoholic fatty liver disease. […] Hepatitis, or inflammation of the liver, can be caused by viruses. Hepatitis A and Hepatitis B are viral strains that can cause hepatitis. […] Liver disease is a growing problem facing Americans. Some people are at increased risk for liver disease because of their genetics. Other causes of liver disease include drinking too much, health conditions like diabetes, and taking too many supplements. […] Alcohol intake is one cause of liver disease. However, its possible to develop liver disease even if you dont drink.

• #86 Risks and causes for liver cancer | Cancer Research UK

  https://www.cancerresearchuk.org/about-cancer/liver-cancer/risks-causes

  Your risk of developing cancer depends on many factors. These include your age, genetics, lifestyle and environmental factors. […] Having cirrhosis increases your risk of getting liver cancer (hepatocellular carcinoma or HCC). The risk varies depending on the cause of the cirrhosis. Cirrhosis can be caused by: long term infection with a virus such as hepatitis B or C, long term alcohol drinking, inherited diseases such as iron overload disorder (haemochromatosis) and alpha 1 antitrypsin deficiency, non-alcoholic fatty liver disease, primary biliary cirrhosis (PBC). […] Smoking increases your risk of many different cancers, including liver cancer. In the UK, 20 out of 100 (20%) cases of liver cancer are caused by smoking. […] Being overweight or obese increases the risk of liver cancer. Diabetes and non alcoholic fatty liver disease are more common in people who are overweight. So this may partly explain the link. More than 20 out of 100 cases of liver cancer (20%) in the UK are caused by being overweight or obese.

• #87 14 signs of liver damage you should know

  https://www.bswhealth.com/blog/14-signs-of-liver-damage-you-should-know

  Liver damage can be caused by a variety of factors, from infections and underlying conditions to lifestyle factors. These are the most common causes of liver damage: Chronic alcohol use and alcohol-related liver disease […] Viral hepatitis, particularly hepatitis B and C […] Non-alcoholic fatty liver disease (often linked to obesity, diabetes and poor diet) […] Autoimmune diseases, like autoimmune hepatitis […] Genetic disorders […] Diseases that affect your bile ducts […] Exposure to toxins or certain medications […] Chronic conditions like Wilsons disease or hemochromatosis. […] Liver damage is on the rise, and lifestyle factors like diet and exercise are a big reason why. It’s because of our lifestyle, said Themis Kourkoumpetis, MD, a transplant hepatologist on the medical staff at Baylor Scott White All Saints Medical Center Fort Worth. We aren’t getting enough exercise, we’re drinking too much soda and we’re eating a large amount of fast food. A growing portion of our population has diabetes, high cholesterol or obesity.

• #88 9 Things That Can Cause Cirrhosis of the Liver

  https://www.health.com/condition/hepatitis-c/what-causes-cirrhosis-liver

  Genetics can also play a role in the health of your liver, and several hereditary conditions can lead to liver disease. […] Certain autoimmune diseases can also impact liver function. […] Numerous medications can affect liver health. […] Acetaminophen in high doses can cause liver failure and even death. […] In addition to acetaminophen, other drugs can also harm your liver. […] While an individual may have little control over whether or not they have a medical condition that increases the risk of liver damage or whether they need to take medications, most individuals have some control over lifestyle habits. […] Smoking can increase the risk of liver cancer and liver cirrhosis. […] Alcohol misuse remains a major cause of cirrhosis and subsequent liver disease. […] Sugar-laden sodas are a notorious cause of weight gain, so it’s not surprising that they’ve also been linked to liver damage. […] Liver damage is associated with several medical conditions and medications.

• #89 Liver Cancer Causes, Risk Factors, and Prevention – NCI

  https://www.cancer.gov/types/liver/what-is-liver-cancer/causes-risk-factors

  The most common type of liver cancer in adults, hepatocellular carcinoma (HCC), typically develops in people with chronic (long-lasting) liver disease caused by hepatitis virus infection or cirrhosis. […] Chronic HBV infection is the leading cause of liver cancer in Asia and Africa. […] Chronic HCV infection is the leading cause of liver cancer in North America, Europe, and Japan. […] The risk of developing liver cancer is increased for people who have cirrhosis, a disease in which healthy liver tissue is replaced by scar tissue. […] Heavy alcohol use can cause cirrhosis, which is a risk factor for liver cancer. […] Having NASH-related cirrhosis increases the risk of developing liver cancer. […] Cigarette smoking has been linked to a higher risk of liver cancer. […] Certain rare medical and genetic conditions may increase the risk of liver cancer.

• #90 Liver Disease: Causes and Risk Factors

  https://www.verywellhealth.com/liver-disease-causes-and-risk-factors-6260092

  Lifestyle factors play a large role in liver disease. The following lifestyle risk factors can become causes of liver disease, especially if youre already genetically predisposed to liver disease. […] The liver breaks down alcohol. But when you drink more than it can process, alcohol begins to damage the liver. This leads to fatty liver disease, where fat builds up in the liver, causing it to become inflamed. Eventually, fatty liver disease can lead to cirrhosis. In fact, alcohol use is the leading cause of cirrhosis. […] Just four drinks a day for males and two drinks a day for females can increase your risk of liver disease. […] But when youre exposed to high levels of toxins like pesticides, they can damage your liver and cause liver disease. […] While most people who take supplements do so in hopes of improving their health, taking too many supplements can increase your risk of liver disease. Up to 20% of liver injuries are caused by supplements, so dont think youre in the clear just because what youre taking is all natural.

• #91 9 Things That Can Cause Cirrhosis of the Liver

  https://www.health.com/condition/hepatitis-c/what-causes-cirrhosis-liver

  You may think alcohol is the only culprit, but many factors can lead to cirrhosis or liver damage. […] Scarring (cirrhosis) can occur if the liver becomes damaged, which can eventually cause liver failure or cancer. […] Other conditions include liver cancer, Wilson disease, and damage caused by alcohol. […] Several health conditions can directly cause or increase the risk of liver damage. Some of these health conditions include obesity, hepatitis, genetic diseases, and various autoimmune conditions. […] Obesity is thought to play a role in nonalcoholic fatty liver disease (NAFLD), which affects about 100 million people in the United States and „will soon be the number-one reason for liver transplantation in the U.S.” […] Chronic hepatitis B and C are responsible for most cases of liver cancer worldwide.

• #92 Risks and causes for liver cancer | Cancer Research UK

  https://www.cancerresearchuk.org/about-cancer/liver-cancer/risks-causes

  Heavy alcohol use increases your risk of liver cancer. Drinking alcohol long term can cause cirrhosis of the liver. Cirrhosis in turn increases the risk of liver cancer. Alcohol might also directly damage the DNA inside liver cells. […] Having non alcoholic fatty liver disease increases your risk of liver cancer. […] Long term infection with the hepatitis B or C virus increases the risk of developing primary liver cancer. This is mainly because these viruses cause damage to the liver (cirrhosis). […] People with diabetes have a higher risk of liver cancer than people who do not have diabetes. […] Studies have shown that people with HIV or AIDS have an increased risk of liver cancer. […] Aflatoxin is a substance found in foods such as mouldy peanuts, wheat, soya beans, groundnuts, corn, rice. People from Africa and Asia who have eaten these over a long period of time have an increased risk of developing liver cancer.

• #93 Risks and causes for liver cancer | Cancer Research UK

  https://www.cancerresearchuk.org/about-cancer/liver-cancer/risks-causes

  Heavy alcohol use increases your risk of liver cancer. Drinking alcohol long term can cause cirrhosis of the liver. Cirrhosis in turn increases the risk of liver cancer. Alcohol might also directly damage the DNA inside liver cells. […] Having non alcoholic fatty liver disease increases your risk of liver cancer. […] Long term infection with the hepatitis B or C virus increases the risk of developing primary liver cancer. This is mainly because these viruses cause damage to the liver (cirrhosis). […] People with diabetes have a higher risk of liver cancer than people who do not have diabetes. […] Studies have shown that people with HIV or AIDS have an increased risk of liver cancer. […] Aflatoxin is a substance found in foods such as mouldy peanuts, wheat, soya beans, groundnuts, corn, rice. People from Africa and Asia who have eaten these over a long period of time have an increased risk of developing liver cancer.

• #94 Risks and causes for liver cancer | Cancer Research UK

  https://www.cancerresearchuk.org/about-cancer/liver-cancer/risks-causes

  There is some evidence that people who chew betel quid have an increased risk of liver cancer. […] People may have an increased risk of liver cancer if they have had gallstones before, or had their gallbladder removed (cholecystectomy). […] There is evidence that exposure to the chemical vinyl chloride increases liver cancer risk. […] People with a family history of liver cancer may have an increased risk of developing it themselves. […] Liver flukes are infections caused by parasites. These infections can increase your risk of liver cancer.

• #95 Cirrhosis

  https://www.nhs.uk/conditions/cirrhosis/

  Cirrhosis is caused by long-term damage to your liver. […] You may be more likely to have cirrhosis if you: regularly drink a lot of alcohol (over 50 units of alcohol a week if you’re a man and over 35 units a week if you’re a woman) […] have hepatitis B or hepatitis C […] live with obesity […] have type 2 diabetes […] have non-alcoholic fatty liver disease (NAFLD) […] have an autoimmune liver condition, such as autoimmune hepatitis, primary biliary cholangitis or primary sclerosing cholangitis […] have a genetic condition, such as haemochromatosis, Wilson’s disease, alpha-1 antitrypsin deficiency or cystic fibrosis. […] How serious cirrhosis is depends on things like what’s causing it and how early it’s diagnosed and treated. […] This usually involves treating the cause, for example, antiviral medicines if it’s caused by hepatitis B or C.

• #96 Liver Cancer Causes, Risk Factors, and Prevention – NCI

  https://www.cancer.gov/types/liver/what-is-liver-cancer/causes-risk-factors

  The most common type of liver cancer in adults, hepatocellular carcinoma (HCC), typically develops in people with chronic (long-lasting) liver disease caused by hepatitis virus infection or cirrhosis. […] Chronic HBV infection is the leading cause of liver cancer in Asia and Africa. […] Chronic HCV infection is the leading cause of liver cancer in North America, Europe, and Japan. […] The risk of developing liver cancer is increased for people who have cirrhosis, a disease in which healthy liver tissue is replaced by scar tissue. […] Heavy alcohol use can cause cirrhosis, which is a risk factor for liver cancer. […] Having NASH-related cirrhosis increases the risk of developing liver cancer. […] Cigarette smoking has been linked to a higher risk of liver cancer. […] Certain rare medical and genetic conditions may increase the risk of liver cancer.

• #97 Alcohol Related Liver Disease | University of Michigan Health

  https://www.uofmhealth.org/conditions-treatments/digestive-and-liver-health/alcohol-related-liver-disease

  Alcohol related liver disease (ALD) is the result of drinking more alcohol than the liver can process, which damages the organ. […] If too much alcohol is ingested repeatedly over time, even without getting drunk, liver damage can silently begin. […] ALD is both preventable and can be fatal. […] Up to 35 percent of heavy drinkers develop alcohol associated hepatitis, which can be mild or severe. […] Alcohol related cirrhosis occurs when the entire liver is scarred, causing the liver to shrink and harden. […] Between 10 to 20 percent of heavy drinkers develop cirrhosis — typically after 10 or more years of drinking. […] Adding alcohol to a liver already taxed by hepatitis increases the risk of developing liver disease, as well as liver cancer.

• #98 Liver diseases: epidemiology, causes, trends and predictions | Signal Transduction and Targeted Therapy

  https://www.nature.com/articles/s41392-024-02072-z

  As a highly complex organ with digestive, endocrine, and immune-regulatory functions, the liver is pivotal in maintaining physiological homeostasis through its roles in metabolism, detoxification, and immune response. Various factors including viruses, alcohol, metabolites, toxins, and other pathogenic agents can compromise liver function, leading to acute or chronic injury that may progress to end-stage liver diseases. […] Liver diseases represent a wide array of disorders characterized by hepatocyte injury, inflammatory cell infiltration, and HSC activation, which cumulatively impair liver function and disrupt its architecture. […] Acute liver diseases often result from hepatotropic virus infections, though drug-induced liver injury (DILI) is also becoming increasingly prevalent worldwide. Chronic liver conditions, on the other hand, typically arise from factors like alcohol consumption, hepatitis B virus (HBV), and hepatitis C virus (HCV) infections, along with a rising incidence of metabolic dysfunction-associated steatotic liver disease (MASLD) globally.

• #99 Liver diseases: epidemiology, causes, trends and predictions | Signal Transduction and Targeted Therapy

  https://www.nature.com/articles/s41392-024-02072-z

  As a highly complex organ with digestive, endocrine, and immune-regulatory functions, the liver is pivotal in maintaining physiological homeostasis through its roles in metabolism, detoxification, and immune response. Various factors including viruses, alcohol, metabolites, toxins, and other pathogenic agents can compromise liver function, leading to acute or chronic injury that may progress to end-stage liver diseases. […] Liver diseases represent a wide array of disorders characterized by hepatocyte injury, inflammatory cell infiltration, and HSC activation, which cumulatively impair liver function and disrupt its architecture. […] Acute liver diseases often result from hepatotropic virus infections, though drug-induced liver injury (DILI) is also becoming increasingly prevalent worldwide. Chronic liver conditions, on the other hand, typically arise from factors like alcohol consumption, hepatitis B virus (HBV), and hepatitis C virus (HCV) infections, along with a rising incidence of metabolic dysfunction-associated steatotic liver disease (MASLD) globally.

• #100 Liver disease – Wikipedia

  https://en.wikipedia.org/wiki/Liver_disease

  Liver diseases can develop through several mechanisms: […] One general mechanism, increased DNA damage, is shared by some of the major liver diseases, including infection by hepatitis B virus or hepatitis C virus, heavy alcohol consumption, and obesity. […] Alcohol consumption in excess causes a build-up of acetaldehyde. […] Obesity is associated with a higher risk of primary liver cancer. […] Several liver diseases are due to viral infection. Viral hepatitides such as Hepatitis B virus and Hepatitis C virus can be vertically transmitted during birth via contact with infected blood.

• #101 Liver disease – Wikipedia

  https://en.wikipedia.org/wiki/Liver_disease

  Liver diseases can develop through several mechanisms: […] One general mechanism, increased DNA damage, is shared by some of the major liver diseases, including infection by hepatitis B virus or hepatitis C virus, heavy alcohol consumption, and obesity. […] Alcohol consumption in excess causes a build-up of acetaldehyde. […] Obesity is associated with a higher risk of primary liver cancer. […] Several liver diseases are due to viral infection. Viral hepatitides such as Hepatitis B virus and Hepatitis C virus can be vertically transmitted during birth via contact with infected blood.

• #102 Liver diseases: epidemiology, causes, trends and predictions | Signal Transduction and Targeted Therapy

  https://www.nature.com/articles/s41392-024-02072-z

  As a highly complex organ with digestive, endocrine, and immune-regulatory functions, the liver is pivotal in maintaining physiological homeostasis through its roles in metabolism, detoxification, and immune response. Various factors including viruses, alcohol, metabolites, toxins, and other pathogenic agents can compromise liver function, leading to acute or chronic injury that may progress to end-stage liver diseases. […] Liver diseases represent a wide array of disorders characterized by hepatocyte injury, inflammatory cell infiltration, and HSC activation, which cumulatively impair liver function and disrupt its architecture. […] Acute liver diseases often result from hepatotropic virus infections, though drug-induced liver injury (DILI) is also becoming increasingly prevalent worldwide. Chronic liver conditions, on the other hand, typically arise from factors like alcohol consumption, hepatitis B virus (HBV), and hepatitis C virus (HCV) infections, along with a rising incidence of metabolic dysfunction-associated steatotic liver disease (MASLD) globally.

• #103 Liver disease – Wikipedia

  https://en.wikipedia.org/wiki/Liver_disease

  Liver diseases can develop through several mechanisms: […] One general mechanism, increased DNA damage, is shared by some of the major liver diseases, including infection by hepatitis B virus or hepatitis C virus, heavy alcohol consumption, and obesity. […] Alcohol consumption in excess causes a build-up of acetaldehyde. […] Obesity is associated with a higher risk of primary liver cancer. […] Several liver diseases are due to viral infection. Viral hepatitides such as Hepatitis B virus and Hepatitis C virus can be vertically transmitted during birth via contact with infected blood.

• #104 What Causes Liver Damage & Disease? | Hep C & Liver Health | Hepatitis NSW

  https://www.hep.org.au/liver-health/what-causes-liver-damage-and-disease/

  Autoimmune Hepatitis (AIH) is when a persons own immune system attacks their liver. The immune system damages the liver cells. AIH is a lifelong illness, which can be treated with medication. If left untreated, AIH can lead to fibrosis and cirrhosis, and some people may need a liver transplant. […] Lifestyle and diet play a big role in your liver health. Too many saturated fats, salts and processed sugars can make it harder for the liver to work as it should, which can lead to inflammation and even scarring. […] There are some high risk lifestyle factors that may lead to liver damage or disease. Heavy drinking, obesity, diabetes and high cholesterol can all affect your liver health.

• #105 Cirrhosis: Practice Essentials, Overview, Epidemiology

  https://emedicine.medscape.com/article/185856-overview

  Damage to liver cells may also lead to hepatocyte apoptosis and the release of damage-associated molecular patterns (DAMPs). […] Activated myofibroblasts have proliferative, fibrogenic, and contractile properties. […] The accumulation of so-called extracellular matrix in the space of Disse can result in the capillarization of hepatic sinusoids, subsequently leading to the development of portal hypertension. […] Multiple scoring systems exist to assess the degree of hepatic fibrosis and cirrhosis. […] The finding of cirrhosis can identify individuals at the highest risk of developing liver decompensation, HCC, or liver-related mortality. […] Specific medical therapies may be applied to many liver diseases to diminish symptoms and to prevent or forestall the development of cirrhosis. […] In some cases, medical therapy particularly in MASH, autoimmune hepatitis, hepatitis B, and hepatitis C may lead to regression of hepatic fibrosis.

• #106 The Stages of Liver Disease – American Liver Foundation

  https://liverfoundation.org/about-your-liver/how-liver-diseases-progress/

  In America, liver disease affects millions and is on the rise. Did you know there are more than 100 different types of liver disease? Living with long-term, chronic liver disease can cause damage to your liver. […] Common Causes of Liver Disease: Viruses, Genetics, Autoimmune disease, Excessive use of alcohol, Poor diet and/or obesity, Reactions to medications, street drugs, or toxic chemicals. […] Most liver diseases damage your liver in similar ways and for many, the progression of liver disease looks the same regardless of the underlying disease. […] Cirrhosis is where your liver is severely scarred and permanently damaged. While the word cirrhosis is most commonly heard when people discuss alcohol-induced liver disease, cirrhosis is caused by many forms of liver disease. […] Liver cancer is cancer that begins in the cells of your liver. While several types of cancer can form in the liver, the most common type of liver cancer is hepatocellular carcinoma, or HCC, which begins in the main type of liver cells (hepatocytes).

• #107 Liver disease – Wikipedia

  https://en.wikipedia.org/wiki/Liver_disease

  Liver disease, or hepatic disease, is any of many diseases of the liver. If long-lasting it is termed chronic liver disease. Although the diseases differ in detail, liver diseases often have features in common. […] Hepatitis, inflammation of the liver, is caused by various viruses (viral hepatitis) also by some liver toxins (e.g. alcoholic hepatitis), autoimmunity (autoimmune hepatitis) or hereditary conditions. […] Alcoholic liver disease is a hepatic manifestation of alcohol overconsumption, including fatty liver disease, alcoholic hepatitis, and cirrhosis. […] Cirrhosis is the formation of fibrous tissue (fibrosis) in the place of liver cells that have died due to a variety of causes, including viral hepatitis, alcohol overconsumption, and other forms of liver toxicity. […] High consumption of alcohol can lead to several forms of liver disease including alcoholic hepatitis, alcoholic fatty liver disease, cirrhosis, and liver cancer.

• #108 Liver Disease: Types of Liver Problems, Causes, and More

  https://www.healthline.com/health/liver-diseases

  Liver disease is a general term that refers to any condition affecting your liver. These conditions may develop for different reasons, but they can all damage your liver and affect its function. […] Many conditions can affect your liver. Heres a look at some of the main ones. […] Hepatitis is defined as an inflammation of the liver. When that inflammation is caused by a virus, its referred to as viral hepatitis. Hepatitis can cause liver damage, making it difficult for your liver to function as it should. […] Fat buildup in the liver can lead to fatty liver disease. There are two types of fatty liver disease. These two types can manifest alone, or they can overlap: alcoholic fatty liver disease, which is caused by heavy alcohol consumption […] nonalcoholic fatty liver disease, which is caused by other factors experts are still trying to understand.

• #109 Chronic Liver Disease: Causes and Symptoms – Alcohol Help

  https://www.alcoholhelp.com/resources/medical-conditions/chronic-liver-disease/

  Chronic liver disease occurs through various health conditions. The most common conditions often stem from alcohol abuse. […] Common causes of chronic liver disease are: Infection, Alcohol abuse, Exposure to toxic chemicals, Blocked or damaged tubes, Hepatitis A, B, C, D, and E, Episodes of heart failure, Viruses, High cholesterol, Autoimmune disorders, Parasitic infection, Certain medications, Heredity. […] Although people can get liver disease from many of the listed reasons, most of the time, chronic liver disease stems from alcoholism. […] The initial stages of liver disease include mild fibrosis of the liver disease through scarring of the liver. This is often caused by alcohol, although other health conditions can produce liver disease. […] Cirrhosis is a condition of scarring on the liver, which can worsen over time. This condition can occur from type 2 diabetes, in men, people older than 50, and alcohol abusers. […] Cirrhosis can be life threatening if not treated, and can increase the risk of infection from other potentially fatal conditions. Most prominently, cirrhosis can lead to liver failure and liver cancer.

• #110 Causes of Liver Diseases | Understand Importance of liver Health

  https://nura.in/blog/causes-of-liver-diseases-and-can-they-lead-to-liver-failure/

  Nura Causes of Liver Diseases December 26, 2022 […] Liver infection can slowly progress over a long time, ultimately resulting in liver failure. However, there is also a condition known as Acute Liver Failure that can occur very quickly, over as little as 48 hours. […] Scarring or cirrhosis occurs when significant parts of the liver are damaged beyond repair. The organ damaged in such a way over large areas cannot function because there is not enough healthy tissue left. When this happens, it is called liver failure. This can be potentially life-threatening, and immediate medical care is imperative. Some kinds of liver disease can also result in cancer when left untreated. […] Chronic Liver Failure: The damage to the liver builds up slowly over several months or even years until the liver can no longer function properly. When the damage is too substantial, the organ stops functioning. In most cases, untreated liver chronic disease is the leading cause.

• #111 Liver Failure: Causes, Symptoms, Treatments, Tests & More

  https://www.webmd.com/fatty-liver-disease/digestive-diseases-liver-failure

  Liver failure happens when your liver starts to shut down. This is usually because it’s become damaged and can’t be repaired. […] Chronic liver disease/cirrhosis (a disease where your liver is permanently scarred) is the 10th leading cause of death in the U.S., according to 2022 government statistics. It causes nearly 55,000 deaths per year. Worldwide, 2 million people die from liver disease every year. […] The causes of acute liver failure, when the liver fails rapidly, include: Acetaminophen overdose: Large doses can damage your liver or lead to failure. […] The most common causes of chronic liver failure include: Hepatitis A, B, and C: These viruses can infect the liver, making it inflamed and unable to work properly. […] Long-term alcohol consumption: Heavy drinking can lead to cirrhosis.

• #112 The Stages of Liver Disease – American Liver Foundation

  https://liverfoundation.org/about-your-liver/how-liver-diseases-progress/

  In America, liver disease affects millions and is on the rise. Did you know there are more than 100 different types of liver disease? Living with long-term, chronic liver disease can cause damage to your liver. […] Common Causes of Liver Disease: Viruses, Genetics, Autoimmune disease, Excessive use of alcohol, Poor diet and/or obesity, Reactions to medications, street drugs, or toxic chemicals. […] Most liver diseases damage your liver in similar ways and for many, the progression of liver disease looks the same regardless of the underlying disease. […] Cirrhosis is where your liver is severely scarred and permanently damaged. While the word cirrhosis is most commonly heard when people discuss alcohol-induced liver disease, cirrhosis is caused by many forms of liver disease. […] Liver cancer is cancer that begins in the cells of your liver. While several types of cancer can form in the liver, the most common type of liver cancer is hepatocellular carcinoma, or HCC, which begins in the main type of liver cells (hepatocytes).

• #113 Liver diseases: epidemiology, causes, trends and predictions | Signal Transduction and Targeted Therapy

  https://www.nature.com/articles/s41392-024-02072-z

  The removal of causative agents such as ethanol and viruses does not always prevent progression to cirrhosis, suggesting that the underlying mechanisms driving disease onset and progression are incompletely understood. […] Liver disease stands as a leading cause of global mortality. […] Liver cancer, a terminal outcome of liver disease, accounted for approximately 830,000 deaths in 2020, representing 8.3% of global cancer-related deaths. […] Chronic liver conditions, on the other hand, typically arise from factors like alcohol consumption, hepatitis B virus (HBV), and hepatitis C virus (HCV) infections, along with a rising incidence of metabolic dysfunction-associated steatotic liver disease (MASLD) globally. […] The leading causes of cirrhosis include MASLD (60%), HBV (29%), HCV (9%), and ALD (2%).

• #114 Liver Failure in Children: Causes, Symptoms, Diagnosis and Treatment | Nationwide Children’s Hospital

  https://www.nationwidechildrens.org/conditions/liver-failure-in-children

  Liver failure can happen to children of any age. The liver can fail due to many different types of injury or disease. Often, a cause cannot even be found. Some known causes of acute (sudden) liver failure include: […] Chronic (slowly developing, long-term) liver failure mostly happens after a child has developed cirrhosis (severe scarring of the liver), for example from some of the diseases listed above. Other possible causes include: […] Liver failure happens when the liver becomes so sick that it stops working. […] Liver failure can be due to many different types of injury or disease. […] Liver failure may come on suddenly (acute) or be a long-lasting disease (chronic). […] Some types of liver failure can be treated with medicine. […] Some children with liver failure will need a liver transplant.

• #115 Cirrhosis in Children | Boston Children’s Hospital

  https://www.childrenshospital.org/conditions/cirrhosis

  Cirrhosis is a progressive liver disease in which scar tissue replaces soft, healthy liver tissue. […] In very young children, cirrhosis is most often caused by a genetic (inherited) liver problem such as biliary atresia. In older children, conditions such as Wilson disease and autoimmune hepatitis can cause cirrhosis. […] The following conditions can lead to cirrhosis in children: biliary atresia, autoimmune hepatitis, chronic viral hepatitis or hepatitis C, cystic fibrosis, alpha-1 antitrypsin deficiency, primary sclerosing cholangitis, Wilson disease, fatty liver disease, some congenital (inherited) heart defects. […] While overconsumption of alcohol is the most common cause of cirrhosis in adults, no amount of alcohol consumption by either parent, even during pregnancy, can cause a child to develop cirrhosis.

• #116 Cirrhosis in Children | Boston Children’s Hospital

  https://www.childrenshospital.org/conditions/cirrhosis

  Cirrhosis is a progressive liver disease in which scar tissue replaces soft, healthy liver tissue. […] In very young children, cirrhosis is most often caused by a genetic (inherited) liver problem such as biliary atresia. In older children, conditions such as Wilson disease and autoimmune hepatitis can cause cirrhosis. […] The following conditions can lead to cirrhosis in children: biliary atresia, autoimmune hepatitis, chronic viral hepatitis or hepatitis C, cystic fibrosis, alpha-1 antitrypsin deficiency, primary sclerosing cholangitis, Wilson disease, fatty liver disease, some congenital (inherited) heart defects. […] While overconsumption of alcohol is the most common cause of cirrhosis in adults, no amount of alcohol consumption by either parent, even during pregnancy, can cause a child to develop cirrhosis.

• #117 Cirrhosis in Children | Boston Children’s Hospital

  https://www.childrenshospital.org/conditions/cirrhosis

  Cirrhosis is a progressive liver disease in which scar tissue replaces soft, healthy liver tissue. […] In very young children, cirrhosis is most often caused by a genetic (inherited) liver problem such as biliary atresia. In older children, conditions such as Wilson disease and autoimmune hepatitis can cause cirrhosis. […] The following conditions can lead to cirrhosis in children: biliary atresia, autoimmune hepatitis, chronic viral hepatitis or hepatitis C, cystic fibrosis, alpha-1 antitrypsin deficiency, primary sclerosing cholangitis, Wilson disease, fatty liver disease, some congenital (inherited) heart defects. […] While overconsumption of alcohol is the most common cause of cirrhosis in adults, no amount of alcohol consumption by either parent, even during pregnancy, can cause a child to develop cirrhosis.

• #118 Understanding liver disease in women | Northwell Health

  https://www.northwell.edu/katz-institute-for-womens-health/articles/liver-disease

  Liver is the only organ that can repair itself but various diseases can cause reversible and irreversible damage. Approximately 5.5 million Americans are currently living with chronic liver disease, and up to 30% of adults have excessive fat in their liver which could lead to more serious liver disease (source: American Liver Foundation). There are more than 100 different liver diseases with some more common in women, including: […] Alcoholic liver disease is more common in women because women absorb more alcohol relative to their body size than men. As little as two drinks a day may be enough to cause this condition. […] Approximately 80 percent of patients diagnosed with autoimmune hepatitis are women. […] Non-alcoholic fatty liver disease affects 60 to 80 million Americans. Excessive fat can be toxic to the liver and cause inflammation. It is the leading cause of cirrhosis in the US with risk factors that include diabetes and obesity.

• #119 Understanding liver disease in women | Northwell Health

  https://www.northwell.edu/katz-institute-for-womens-health/articles/liver-disease

  Liver is the only organ that can repair itself but various diseases can cause reversible and irreversible damage. Approximately 5.5 million Americans are currently living with chronic liver disease, and up to 30% of adults have excessive fat in their liver which could lead to more serious liver disease (source: American Liver Foundation). There are more than 100 different liver diseases with some more common in women, including: […] Alcoholic liver disease is more common in women because women absorb more alcohol relative to their body size than men. As little as two drinks a day may be enough to cause this condition. […] Approximately 80 percent of patients diagnosed with autoimmune hepatitis are women. […] Non-alcoholic fatty liver disease affects 60 to 80 million Americans. Excessive fat can be toxic to the liver and cause inflammation. It is the leading cause of cirrhosis in the US with risk factors that include diabetes and obesity.

• #120 Understanding liver disease in women | Northwell Health

  https://www.northwell.edu/katz-institute-for-womens-health/articles/liver-disease

  Liver is the only organ that can repair itself but various diseases can cause reversible and irreversible damage. Approximately 5.5 million Americans are currently living with chronic liver disease, and up to 30% of adults have excessive fat in their liver which could lead to more serious liver disease (source: American Liver Foundation). There are more than 100 different liver diseases with some more common in women, including: […] Alcoholic liver disease is more common in women because women absorb more alcohol relative to their body size than men. As little as two drinks a day may be enough to cause this condition. […] Approximately 80 percent of patients diagnosed with autoimmune hepatitis are women. […] Non-alcoholic fatty liver disease affects 60 to 80 million Americans. Excessive fat can be toxic to the liver and cause inflammation. It is the leading cause of cirrhosis in the US with risk factors that include diabetes and obesity.

• #121 Understanding liver disease in women | Northwell Health

  https://www.northwell.edu/katz-institute-for-womens-health/articles/liver-disease

  Diagnosed almost exclusively in women, this chronic condition causes bile ducts in the liver to slowly be destroyed. […] Benign liver tumors are more common in women. Certain types have been linked to oral contraceptive use where higher doses of estrogen were used. […] Cirrhosis is a consequence of any chronic liver disease and can lead to such complications as hepatic encephalopathy, esophageal varices, abdominal ascites, liver failure and liver cancer. […] Liver disease is common in women, and it is widely underdiagnosed, says Dr. David Bernstein, chief, Division of Hepatology at Northwell Health. By keeping alcohol intake low, maintaining a healthy diet and exercising regularly, women can significantly reduce their chance of developing some of the most common types of liver disease.

• #122 Understanding liver disease in women | Northwell Health

  https://www.northwell.edu/katz-institute-for-womens-health/articles/liver-disease

  Diagnosed almost exclusively in women, this chronic condition causes bile ducts in the liver to slowly be destroyed. […] Benign liver tumors are more common in women. Certain types have been linked to oral contraceptive use where higher doses of estrogen were used. […] Cirrhosis is a consequence of any chronic liver disease and can lead to such complications as hepatic encephalopathy, esophageal varices, abdominal ascites, liver failure and liver cancer. […] Liver disease is common in women, and it is widely underdiagnosed, says Dr. David Bernstein, chief, Division of Hepatology at Northwell Health. By keeping alcohol intake low, maintaining a healthy diet and exercising regularly, women can significantly reduce their chance of developing some of the most common types of liver disease.

• #123 Liver Failure: Symptoms & Causes | NewYork-Presbyterian

  https://www.nyp.org/digestive/liver-failure

  Alcohol-associated hepatitis involves liver inflammation that results from heavy or long-term drinking. […] Autoimmune hepatitis, in which the body’s immune system attacks the liver and causes inflammation. […] Cirrhosis. Drinking alcohol for many years, or having chronic hepatitis B or C infection, can create scarring on your liver, making it difficult for your liver to work. […] Nonalcoholic fatty liver disease (NAFLD) is characterized by fat cell deposits in the liver. NAFLD typically affects people who have diabetes, high cholesterol, high blood pressure, and/or weight problems. […] Acute fatty liver during pregnancy. Excess fat builds up on the liver, causing damage. […] A common cause of acute liver failure is taking too much acetaminophen (otherwise known as Tylenol and other over-the-counter brands).

• #124 Alcoholic liver disease: Symptoms, treatment, and causes

  https://www.medicalnewstoday.com/articles/215638

  Females are more susceptible to the negative effects of alcohol, even at the same levels of alcohol intake as males, so are more likely to quickly develop fibrosis, inflammation, and liver injury as a result of alcohol. […] Having hepatitis C increases the risk, and a person who consumes alcohol regularly and has had any type of hepatitis faces a higher chance of developing liver disease. […] Genetic changes can affect the risk. If a person experiences changes in the genetic profiles of particular enzymes that are key to alcohol metabolisms, such as ADH, ALDH, and CYP4502E1, they will have a higher chance of developing alcoholic liver disease.

• #125 Alcoholic fatty liver disease | Carr Lab | Perelman School of Medicine at the University of Pennsylvania

  https://www.med.upenn.edu/carr-lab/alcoholic-liver-disease.html

  Chronic alcohol abuse can lead to liver damage called alcoholic fatty liver disease. […] Excessive alcohol use can cause swelling and inflammation of the liver, and chronic excessive alcohol consumption can lead to scarring (fibrosis) and cirrhosis of the liver. Cirrhosis is the final phase of alcoholic liver disease; at this stage the liver damage is unfortunately irreversible. […] The first treatment line is to stop drinking alcohol completely. […] In the early stages of liver disease, stop drinking will allow the liver to heal itself.

• #126 Cirrhosis in adults: Etiologies, clinical manifestations, and diagnosis – UpToDate

  https://www.uptodate.com/contents/cirrhosis-in-adults-etiologies-clinical-manifestations-and-diagnosis

  Cirrhosis represents a late stage of progressive hepatic fibrosis characterized by distortion of the hepatic architecture and the formation of regenerative nodules. It is generally considered to be irreversible in its advanced stages, at which point the only treatment option may be liver transplantation. However, reversal of cirrhosis (in its earlier stages) has been documented in several forms of liver disease following treatment of the underlying cause. Patients with cirrhosis are susceptible to a variety of complications, and their life expectancy is markedly reduced. […] There are numerous causes of liver disease that can result in cirrhosis, either by causing chronic hepatic inflammation or cholestasis. In resource-abundant countries, common causes of cirrhosis include: […] Alcohol-associated liver disease […] Metabolic dysfunction-associated steatotic liver disease.

• #127 Cirrhosis: Practice Essentials, Overview, Epidemiology

  https://emedicine.medscape.com/article/185856-overview

  Damage to liver cells may also lead to hepatocyte apoptosis and the release of damage-associated molecular patterns (DAMPs). […] Activated myofibroblasts have proliferative, fibrogenic, and contractile properties. […] The accumulation of so-called extracellular matrix in the space of Disse can result in the capillarization of hepatic sinusoids, subsequently leading to the development of portal hypertension. […] Multiple scoring systems exist to assess the degree of hepatic fibrosis and cirrhosis. […] The finding of cirrhosis can identify individuals at the highest risk of developing liver decompensation, HCC, or liver-related mortality. […] Specific medical therapies may be applied to many liver diseases to diminish symptoms and to prevent or forestall the development of cirrhosis. […] In some cases, medical therapy particularly in MASH, autoimmune hepatitis, hepatitis B, and hepatitis C may lead to regression of hepatic fibrosis.

• #128 Liver Failure – End Stage Liver Disease – UChicago Medicine

  https://www.uchicagomedicine.org/conditions-services/liver-diseases-hepatology/liver-failure

  Liver failure is when the liver has shut down or is shutting down and can no longer work properly. Cirrhosis is a late stage of liver disease where the liver is severely scarred but may still work. Most patients who develop chronic liver failure have underlying cirrhosis. […] However, once cirrhosis develops, the liver usually cannot repair itself.

• #129 Cirrhosis in adults: Etiologies, clinical manifestations, and diagnosis – UpToDate

  https://www.uptodate.com/contents/cirrhosis-in-adults-etiologies-clinical-manifestations-and-diagnosis

  Cirrhosis represents a late stage of progressive hepatic fibrosis characterized by distortion of the hepatic architecture and the formation of regenerative nodules. It is generally considered to be irreversible in its advanced stages, at which point the only treatment option may be liver transplantation. However, reversal of cirrhosis (in its earlier stages) has been documented in several forms of liver disease following treatment of the underlying cause. Patients with cirrhosis are susceptible to a variety of complications, and their life expectancy is markedly reduced. […] There are numerous causes of liver disease that can result in cirrhosis, either by causing chronic hepatic inflammation or cholestasis. In resource-abundant countries, common causes of cirrhosis include: […] Alcohol-associated liver disease […] Metabolic dysfunction-associated steatotic liver disease.

• #130 Liver disease

  https://www.nhs.uk/conditions/liver-disease/

  There are many different types of liver disease. […] There are several types of liver disease, which can have different causes. […] Common types of liver disease and the possible causes Condition Possible causes Alcohol-related liver disease Regularly drinking too much alcohol Non-alcoholic fatty liver disease Being very overweight (obese) this may cause fat to build up in the liver Hepatitis Catching a viral infection or regularly drinking too much alcohol Haemochromatosis A gene that runs in families and may be passed from parents to children Primary biliary cholangitis May be caused by a problem with the immune system. […] The 3 main causes of liver disease are: obesity, an undiagnosed hepatitis infection, alcohol misuse.

• #131 Liver diseases: epidemiology, causes, trends and predictions | Signal Transduction and Targeted Therapy

  https://www.nature.com/articles/s41392-024-02072-z

  The removal of causative agents such as ethanol and viruses does not always prevent progression to cirrhosis, suggesting that the underlying mechanisms driving disease onset and progression are incompletely understood. […] Liver disease stands as a leading cause of global mortality. […] Liver cancer, a terminal outcome of liver disease, accounted for approximately 830,000 deaths in 2020, representing 8.3% of global cancer-related deaths. […] Chronic liver conditions, on the other hand, typically arise from factors like alcohol consumption, hepatitis B virus (HBV), and hepatitis C virus (HCV) infections, along with a rising incidence of metabolic dysfunction-associated steatotic liver disease (MASLD) globally. […] The leading causes of cirrhosis include MASLD (60%), HBV (29%), HCV (9%), and ALD (2%).

• #132 What Causes Liver Damage & Disease? | Hep C & Liver Health | Hepatitis NSW

  https://www.hep.org.au/liver-health/what-causes-liver-damage-and-disease/

  Liver damage is usually caused by viral infections, lifestyle, diet and our bodys immune system. If left untreated liver damage can cause serious health problems. […] Hepatitis B is the most common liver infection in the world, people mostly get it at birth if their mother has hepatitis B. […] Hepatitis C is an easily cured liver infection, caused by the hepatitis C virus. The new treatments for hepatitis C cure up to 95% of people and only take around 12 weeks. If left untreated, hepatitis C can cause serious health problems. […] Alcohol-related hepatitis is a very common form of liver disease in Australia. As the name suggests, it is caused by excessive use of alcohol. […] Non-alcoholic fatty liver disease (NAFLD) happens when fat begins to build up in your liver. NAFLD can be caused by a range of conditions but its usually linked to being overweight or obese.

• #133 What Causes Liver Damage & Disease? | Hep C & Liver Health | Hepatitis NSW

  https://www.hep.org.au/liver-health/what-causes-liver-damage-and-disease/

  Autoimmune Hepatitis (AIH) is when a persons own immune system attacks their liver. The immune system damages the liver cells. AIH is a lifelong illness, which can be treated with medication. If left untreated, AIH can lead to fibrosis and cirrhosis, and some people may need a liver transplant. […] Lifestyle and diet play a big role in your liver health. Too many saturated fats, salts and processed sugars can make it harder for the liver to work as it should, which can lead to inflammation and even scarring. […] There are some high risk lifestyle factors that may lead to liver damage or disease. Heavy drinking, obesity, diabetes and high cholesterol can all affect your liver health.

• #134 Cirrhosis: Practice Essentials, Overview, Epidemiology

  https://emedicine.medscape.com/article/185856-overview

  More than 40% of US adults are affected by some type of chronic liver disease, of which the most common causes include metabolic dysfunction-associated steatotic liver disease (MASLD), alcohol-associated liver disease (ALD), hepatitis C, and hepatitis B. […] Other causes of chronic liver disease and cirrhosis include autoimmune hepatitis, primary biliary cholangitis, secondary biliary cirrhosis, primary sclerosing cholangitis, hereditary hemochromatosis, alpha-1 antitrypsin deficiency, Wilson disease, granulomatous disease, drug-induced liver disease, venous outflow obstruction, chronic right-sided heart failure, and tricuspid regurgitation. […] Even cirrhosis develops, these individuals may not go on to decompensate and die from cirrhosis. […] The initial step in fibrogenesis is likely the stimulation of immune cells within the liver by an insult whether toxic, metabolic, or caused by viral infection.

• #135 Liver diseases: epidemiology, causes, trends and predictions | Signal Transduction and Targeted Therapy

  https://www.nature.com/articles/s41392-024-02072-z

  As a highly complex organ with digestive, endocrine, and immune-regulatory functions, the liver is pivotal in maintaining physiological homeostasis through its roles in metabolism, detoxification, and immune response. Various factors including viruses, alcohol, metabolites, toxins, and other pathogenic agents can compromise liver function, leading to acute or chronic injury that may progress to end-stage liver diseases. […] Liver diseases represent a wide array of disorders characterized by hepatocyte injury, inflammatory cell infiltration, and HSC activation, which cumulatively impair liver function and disrupt its architecture. […] Acute liver diseases often result from hepatotropic virus infections, though drug-induced liver injury (DILI) is also becoming increasingly prevalent worldwide. Chronic liver conditions, on the other hand, typically arise from factors like alcohol consumption, hepatitis B virus (HBV), and hepatitis C virus (HCV) infections, along with a rising incidence of metabolic dysfunction-associated steatotic liver disease (MASLD) globally.

• #136 Liver diseases: epidemiology, causes, trends and predictions | Signal Transduction and Targeted Therapy

  https://www.nature.com/articles/s41392-024-02072-z

  Despite often presenting similar clinicopathological features ranging from asymptomatic stages to nonspecific digestive symptoms, these liver diseases share biochemical and histological profiles that complicate their differentiation based on a single diagnostic parameter. […] The underlying mechanisms driving disease onset and progression are incompletely understood.

• #137 Liver Disease: Types of Liver Problems, Causes, and More

  https://www.healthline.com/health/liver-diseases

  Chronic liver failure typically happens when a significant part of your liver is damaged and cant function properly. […] Certain things can make you more likely to develop certain liver diseases. One of the most well-known risk factors is heavy drinking, which the Centers for Disease Control and Prevention (CDC) defines as more than 8 alcoholic drinks per week for women and more than 15 drinks per week for men. […] While not all liver disease or damage can be prevented, lifestyle choices can make a big difference when it comes to keeping your liver healthy. […] Many liver diseases are chronic, meaning they last for years and may never go away. But even chronic liver diseases can usually be managed. […] The complications of untreated or unmanaged liver disease can lead to cirrhosis, severe scarring that cannot be reversed. If cirrhosis has gone too far, a liver transplant may be your only option.

• #138 Liver Fibrosis: Causes, Symptoms, Diagnosis & Treatment | Hoag Digestive Health Institute

  https://www.hoag.org/specialties-services/digestive-health/diseases-conditions/liver-fibrosis/

  Liver fibrosis is scarring of the liver thats usually caused by inflammation due to issues like alcoholism, chronic hepatitis, nonalcoholic fatty liver disease and other conditions. […] The body attempts to repair this damage by depositing collagen and other proteins in the injured liver tissue, where it begins to form scar tissue. […] If liver inflammation and damage continues due to a chronic condition, more and more collagen is deposited in the liver, causing more and more scar tissue to form. […] Without treatment, long-term fibrosis can eventually progress to an advanced form called cirrhosis. […] There are a number of factors that may increase your risk of developing liver fibrosis. These may include: Alcohol abuse, Nonalcoholic Fatty Liver Disease (NAFLD), which is a condition that can cause fat to build up in your liver, damaging the tissue in a way similar to long-term alcoholism, even in those who drink little to no alcohol, Chronic Hepatitis C, Chronic Hepatitis B, Autoimmune hepatitis, in which the bodys immune system attacks the liver and causes tissue damage. […] For now, with early detection, doctors can help patients take steps to stop the progression of fibrosis, including managing or treating conditions like nonalcoholic fatty liver disease, alcoholism or chronic hepatitis B or C that may have caused the inflammation that led to liver fibrosis.

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