Choroba addisona
Zapobieganie i profilaktyka
Choroba Addisona, czyli pierwotna niedoczynność kory nadnerczy, jest schorzeniem endokrynologicznym, które nie podlega całkowitej profilaktyce, jednak odpowiednie działania mogą zapobiec przełomowi nadnerczowemu – stanowi on powikłanie zagrażające życiu. Kluczowe znaczenie ma edukacja pacjenta i jego otoczenia w zakresie rozpoznawania wczesnych objawów przełomu oraz dostosowywania dawek glikokortykosteroidów w sytuacjach stresowych. W przypadku ciężkiego stresu, np. poważnych operacji lub infekcji, zaleca się podawanie hydrokortyzonu dożylnie w dawce 50 mg co 6 godzin (około 8-krotność fizjologicznej produkcji), natomiast przy umiarkowanym stresie dawkę podtrzymującą należy podwoić lub potroić (zwykle 50-75 mg/dobę hydrokortyzonu). Pacjenci powinni mieć przy sobie zestaw awaryjny z 100 mg hydrokortyzonu do iniekcji oraz nosić identyfikatory medyczne zawierające informacje o chorobie i stosowanych lekach, co umożliwia szybkie wdrożenie odpowiedniego leczenia.
- Profilaktyka choroby Addisona (Choroba Addisona – Prewencja)
- Zapobieganie przełomu nadnerczowego
- Styl życia i zalecenia profilaktyczne
- Regularne kontrole medyczne
- Choroba Addisona w ciąży
- Postępowanie w przypadku choroby współistniejącej
- Zapobieganie jatrogennemu zespołowi Addisona
- Nowoczesne podejście do terapii zastępczej
- Podsumowanie działań profilaktycznych w chorobie Addisona
Profilaktyka choroby Addisona (Choroba Addisona – Prewencja)
Choroba Addisona (pierwotna niedoczynność kory nadnerczy) jest rzadkim schorzeniem endokrynologicznym, które niestety nie może być całkowicie zapobieżone.123 Mimo to, istnieje szereg działań profilaktycznych, które mogą zapobiec rozwojowi przełomu nadnerczowego (przełomu Addisonowskiego) – stanu zagrażającego życiu pacjenta z tą chorobą.
Zapobieganie przełomu nadnerczowego
Przełom nadnerczowy stanowi ostre, zagrażające życiu powikłanie przyczyniające się do zwiększonej śmiertelności pacjentów z niedoczynnością kory nadnerczy.4 Kluczowe działania zapobiegawcze obejmują:
Edukacja pacjenta
Edukacja pacjenta stanowi najważniejszy element profilaktyki przełomu nadnerczowego.5 Każdy pacjent powinien zostać dokładnie poinstruowany w zakresie:
- Rozpoznawania wczesnych objawów przełomu nadnerczowego67
- Dostosowywania dawek glikokortykosteroidów w sytuacjach stresowych89
- Stosowania pozajelitowych form glikokortykosteroidów w sytuacjach nagłych10
- Prowadzenia zrównoważonego stylu życia11
Istotne jest, aby nie tylko pacjenci, ale również ich opiekunowie, partnerzy i członkowie rodziny byli świadomi objawów zbliżającego się przełomu i prawidłowego dostosowania dawki leków glikokortykosteroidowych.12
Dostosowanie dawek leków w sytuacjach stresowych
Pacjenci z chorobą Addisona powinni zwiększać dawki glikokortykosteroidów podczas:
- Ciężkiego stresu (np. poważne operacje, ciężkie infekcje) – zaleca się podawanie 50 mg hydrokortyzonu dożylnie co 6 godzin, co stanowi około ośmiokrotność normalnej fizjologicznej produkcji steroidów13
- Umiarkowanego stresu – należy podwoić lub potroić dawkę podtrzymującą steroidów (zazwyczaj 50-75 mg/dobę hydrokortyzonu w dwóch lub trzech dawkach podzielonych)14
- Ciężkiego i długotrwałego stresu psychologicznego lub przedłużonego wysiłku fizycznego – można rozważyć dodatkową dawkę hydrokortyzonu15
Zgodnie z zaleceniami ekspertów, podczas choroby, operacji lub innych sytuacji stresowych należy zwiększyć dawkę glikokortykosteroidów, aby zapobiec rozwojowi przełomu nadnerczowego.1617
Zestaw ratunkowy z glikokortykosteroidami
Zapewnienie zestawu do iniekcji awaryjnej hydrokortyzonu jest standardową praktyką w zapobieganiu ostrego przełomu nadnerczowego.18 Pacjenci powinni:
- Zawsze mieć przy sobie fiolkę zawierającą 100 mg hydrokortyzonu do wstrzyknięć, wraz z odpowiednimi igłami, strzykawkami i wodą do iniekcji1920
- Posiadać co najmniej dwa zestawy iniekcji awaryjnej (zgodnie z wytycznymi NICE), co zapewni dostępność na wypadek podróży lub uszkodzenia fiolki21
- Nauczyć członka rodziny lub bliskiego przyjaciela, jak podawać zastrzyk z hydrokortyzonem w przypadku, gdy pacjent jest zbyt słaby, aby zrobić to samodzielnie22
Zestawy awaryjne powinny być przechowywane w domu, w pracy lub szkole oraz noszone w torebce lub plecaku.2324
Identyfikacja medyczna i karty alarmowe
Wszyscy pacjenci z chorobą Addisona powinni nosić identyfikatory medyczne:25
- Kartę awaryjną dotyczącą steroidów2627
- Bransoletkę lub naszyjnik medyczny informujący o chorobie2829
- Kartę informacyjną zawierającą dane o stosowanych lekach, ich dawkach oraz dane kontaktowe do lekarza prowadzącego i członków rodziny30
Na identyfikatorze medycznym powinien być wskazany rodzaj leku oraz jego dokładna dawka, co pomoże personelowi medycznemu w szybkim wdrożeniu odpowiedniego leczenia.31
Styl życia i zalecenia profilaktyczne
Mimo że nie można zapobiec chorobie Addisona, właściwy styl życia może pomóc w jej kontrolowaniu i zapobieganiu powikłaniom:32
Dieta i nawodnienie
- Spożycie soli – pacjenci z niskim poziomem aldosteronu mogą wymagać diety bogatej w sód; należy skonsultować się z lekarzem w sprawie odpowiedniej ilości sodu w diecie3334
- Unikanie ograniczania soli – nie należy ograniczać spożycia soli; w okresach upałów i wilgotnej pogody lub po wysiłku fizycznym może być konieczne dodatkowe przyjmowanie soli, aby uzupełnić straty związane z poceniem się35
- Zbilansowana dieta – zaleca się spożywanie zbilansowanych posiłów z wystarczającą ilością zwykłej soli stołowej36
- Odpowiednia podaż płynów – należy przyjmować dużą ilość zdrowych płynów w ciągu dnia37
- Suplementacja wapnia i witaminy D – w celu zapobiegania osteoporozie związanej z długotrwałym stosowaniem kortykosteroidów38
Aktywność fizyczna i stres
- Unikanie stresu – należy unikać sytuacji stresowych39
- Umiarkowany wysiłek fizyczny – należy unikać intensywnych ćwiczeń lub pracy fizycznej w gorącym i wilgotnym klimacie40
- Równowaga między aktywnością a odpoczynkiem – aktywność fizyczną należy równoważyć odpowiednim odpoczynkiem41
Regularne kontrole medyczne
Regularne wizyty u specjalisty endokrynologa są kluczowe dla monitorowania stanu zdrowia i dostosowywania leczenia:42
- Wizyty u endokrynologa co najmniej raz w roku4344
- Regularne badania przesiewowe w kierunku chorób autoimmunologicznych45
- Regularne ważenie się i kontrola ciśnienia krwi – należy informować lekarza o utracie wagi lub zbyt wysokim/niskim ciśnieniu krwi46
- Uczestniczenie w zaplanowanych badaniach kontrolnych i pobieraniu krwi w celu monitorowania poziomów hormonów47
Choroba Addisona w ciąży
Kobiety z chorobą Addisona zazwyczaj mogą mieć zdrową ciążę, poród i połóg, jednak wymagają one specjalistycznej opieki:4849
- Multidyscyplinarny zespół – pacjentki powinny być monitorowane przez położnika i endokrynologa specjalizującego się w niedoczynności kory nadnerczy50
- Dostosowanie dawek leków – często konieczne jest zwiększenie dawki glikokortykosteroidów podczas ciąży51
- Planowanie porodu – poród musi być zaplanowany i monitorowany przez multidyscyplinarny zespół; endokrynolog powinien dostarczyć zespołowi położniczemu pisemny plan terapeutyczny dotyczący dożylnego podawania glikokortykosteroidów przed aktywną fazą porodu (początkowy bolus 100 mg hydrokortyzonu, a następnie ciągła infuzja 200-300 mg/24h)52
- Monitorowanie kliniczne – monitorowanie w okresie ciąży opiera się głównie na objawach klinicznych i jest szczególnie trudne w tym okresie53
Postępowanie w przypadku choroby współistniejącej
W przypadku wystąpienia choroby lub infekcji, pacjenci z chorobą Addisona powinni:5455
- Skontaktować się z lekarzem w przypadku wystąpienia objawów takich jak nudności, wymioty, gorączka, osłabienie, zmęczenie lub utrata masy ciała5657
- Dostosować dawkę przyjmowanych leków zgodnie z zaleceniami lekarza5859
- Stosować lek w formie iniekcji, jeśli nie jest możliwe przyjmowanie leków doustnych6061
- Udać się na oddział ratunkowy w przypadku ciężkiej choroby, szczególnie jeśli występują wymioty uniemożliwiające przyjmowanie leków doustnych6263
Zapobieganie jatrogennemu zespołowi Addisona
Jatrogenną chorobę Addisona można wywołać poprzez nieprawidłowe stosowanie terapii steroidowej:64
- Zarządzanie dawkami, czasem trwania i odstawianiem steroidów – kluczowe dla zminimalizowania ryzyka jatrogennej choroby Addisona65
- Unikanie nagłego odstawienia steroidów – może to wywołać przełom nadnerczowy; odstawianie musi być powolne i stopniowe, aby zapobiec zaburzeniom poziomu kortyzolu66
- Monitorowanie pacjentów stosujących przewlekłą terapię steroidową – długotrwałe stosowanie wysokich dawek steroidów może prowadzić do supresji nadnerczy67
W przypadku chorób takich jak zespół Cushinga, leki stosowane w terapii (np. mitotan lub trilostan) mogą potencjalnie prowadzić do rozwoju choroby Addisona, dlatego należy ściśle przestrzegać zaleceń lekarza dotyczących dawkowania tych leków.68
Nowoczesne podejście do terapii zastępczej
Rozwijane są nowe podejścia do terapii zastępczej glikokortykosteroidami:69
- Formy o przedłużonym uwalnianiu – podwójne lub modyfikowane formy uwalniania hydrokortyzonu próbują dokładniej naśladować fizjologiczne uwalnianie kortyzolu, poprawiając jakość życia pacjentów70
- Indywidualizacja terapii – dostosowanie terapii do potrzeb pacjenta jest kluczowe dla uniknięcia powikłań związanych z niedostateczną lub nadmierną dawką leków71
Należy pamiętać, że pacjenci z chorobą Addisona przyjmujący glikokortykosteroidy w dawkach zastępczych rzadko doświadczają poważnych działań niepożądanych związanych z wysokimi dawkami tych leków, ponieważ przepisywane dawki są znacznie niższe i jedynie zastępują brakujące hormony.72
Podsumowanie działań profilaktycznych w chorobie Addisona
Choć choroby Addisona nie można zapobiec, odpowiednie postępowanie może znacząco zmniejszyć ryzyko przełomu nadnerczowego i innych powikłań. Edukacja pacjenta, dostosowywanie dawek leków w sytuacjach stresowych, noszenie identyfikatorów medycznych, posiadanie zestawu awaryjnego z hydrokortyzonem oraz regularne kontrole lekarskie stanowią podstawę profilaktyki u pacjentów z tą chorobą.7374
Pacjenci z chorobą Addisona, którzy przestrzegają zaleceń lekarskich i są odpowiednio edukowani w zakresie swojej choroby, mogą prowadzić normalne, zdrowe życie, mimo konieczności przyjmowania leków przez całe życie.75
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Materiały źródłowe
- #1 Addison’s Disease: What It Is, Causes, Symptoms & Treatmenthttps://my.clevelandclinic.org/health/diseases/15095-addisons-disease
Unfortunately, theres nothing you can do to prevent Addisons disease. […] The prognosis for Addisons disease is generally good. Although people who have Addisons disease will need to take medicine for the rest of their lives, they can live normal, healthy lives.
- #2 Addisonâs Disease – familydoctor.orghttps://familydoctor.org/condition/addisons-disease/
Addison’s disease cannot be prevented or avoided.
- #3 Managing Your Addison’s Disease â Symptoms & Treatment | Carle.orghttps://carle.org/conditions/addison-s-disease
There is no effective way to prevent Addisons disease. […] DO avoid stress. […] DO watch your lifestyle. Drink alcohol only in moderation. Eat a well-balanced diet with enough regular table salt. […] DO call your health care provider when you feel poorly (nausea, vomiting, fever) or feel weak and tired and have weight loss.
- #4 Adrenal crisis: prevention and management in adult patientshttps://pmc.ncbi.nlm.nih.gov/articles/PMC6566489/
Adrenal crisis is an acute life-threatening emergency contributing to the excess mortality that is reported in patients with adrenal insufficiency. […] Prevention is centred around patient education. All patients should be educated on stress dosing and parenteral glucocorticoid administration. […] Patient education is the most important component in the prevention of adrenal crisis. […] An additional dose of hydrocortisone may be considered in situations of severe and prolonged psychological stress, or prolonged physical exercise. […] It is important that patients, caregivers and family members are aware of the symptoms of an impending crisis. […] Guidelines recommend that all patients should carry steroid emergency cards. […] Education of patients and partner/family members regarding symptom awareness and the correct adjustment of glucocorticoid replacement dose is imperative.
- #5 Adrenal crisis: prevention and management in adult patientshttps://pmc.ncbi.nlm.nih.gov/articles/PMC6566489/
Adrenal crisis is an acute life-threatening emergency contributing to the excess mortality that is reported in patients with adrenal insufficiency. […] Prevention is centred around patient education. All patients should be educated on stress dosing and parenteral glucocorticoid administration. […] Patient education is the most important component in the prevention of adrenal crisis. […] An additional dose of hydrocortisone may be considered in situations of severe and prolonged psychological stress, or prolonged physical exercise. […] It is important that patients, caregivers and family members are aware of the symptoms of an impending crisis. […] Guidelines recommend that all patients should carry steroid emergency cards. […] Education of patients and partner/family members regarding symptom awareness and the correct adjustment of glucocorticoid replacement dose is imperative.
- #6 Adrenal crisis: prevention and management in adult patientshttps://pmc.ncbi.nlm.nih.gov/articles/PMC6566489/
Adrenal crisis is an acute life-threatening emergency contributing to the excess mortality that is reported in patients with adrenal insufficiency. […] Prevention is centred around patient education. All patients should be educated on stress dosing and parenteral glucocorticoid administration. […] Patient education is the most important component in the prevention of adrenal crisis. […] An additional dose of hydrocortisone may be considered in situations of severe and prolonged psychological stress, or prolonged physical exercise. […] It is important that patients, caregivers and family members are aware of the symptoms of an impending crisis. […] Guidelines recommend that all patients should carry steroid emergency cards. […] Education of patients and partner/family members regarding symptom awareness and the correct adjustment of glucocorticoid replacement dose is imperative.
- #7 Patient education: Adrenal insufficiency (Beyond the Basics) – UpToDatehttps://www.uptodate.com/contents/adrenal-insufficiency-beyond-the-basics
People with adrenal insufficiency should learn as much as possible about their condition and should be aware of early warning signs of hormone deficiency. It is important to share this information with family, friends, and any caregivers, so that they can also identify signs of trouble and be prepared to act in case of adrenal crisis. […] People with adrenal insufficiency should wear a medical alert bracelet or necklace. They should also carry an emergency medical information card that lists the names and doses of their daily medications and the health care provider and family member(s) to call in case of emergency. It is extremely important to identify early symptoms of adrenal insufficiency and adrenal crisis; your provider can talk to you about subtle symptoms that should not be ignored.
- #8 Adrenal crisis: prevention and management in adult patientshttps://pmc.ncbi.nlm.nih.gov/articles/PMC6566489/
Adrenal crisis is an acute life-threatening emergency contributing to the excess mortality that is reported in patients with adrenal insufficiency. […] Prevention is centred around patient education. All patients should be educated on stress dosing and parenteral glucocorticoid administration. […] Patient education is the most important component in the prevention of adrenal crisis. […] An additional dose of hydrocortisone may be considered in situations of severe and prolonged psychological stress, or prolonged physical exercise. […] It is important that patients, caregivers and family members are aware of the symptoms of an impending crisis. […] Guidelines recommend that all patients should carry steroid emergency cards. […] Education of patients and partner/family members regarding symptom awareness and the correct adjustment of glucocorticoid replacement dose is imperative.
- #9 Addison’s disease – Symptoms and causes – Mayo Clinichttps://www.mayoclinic.org/diseases-conditions/addisons-disease/symptoms-causes/syc-20350293
Addison’s disease can’t be prevented. But you can take steps to lower the risk of adrenal crisis: […] Talk with your healthcare professional if you always feel tired or weak or are losing weight without trying. Ask if you should get tested for adrenal insufficiency. […] If you have Addison’s disease, ask your healthcare professional what to do when you’re sick. You’ll likely need to learn how to adjust the amount of medicine that you take. You also may need to take the medicine as a shot. […] If you become very sick, go to an emergency room. This is crucial if you’re vomiting and you can’t take your medicine. […] Some people with Addison’s disease worry about serious side effects from corticosteroid medicines. But people with Addison’s disease aren’t likely to get the side effects of high-dose corticosteroids used to treat many other diseases. That’s because the dose prescribed is much lower and only replaces the amount that’s missing. […] If you take corticosteroids, follow up with your healthcare professional regularly to make sure your dose is not too high.
- #10 Adrenal crisis: prevention and management in adult patientshttps://pmc.ncbi.nlm.nih.gov/articles/PMC6566489/
Adrenal crisis is an acute life-threatening emergency contributing to the excess mortality that is reported in patients with adrenal insufficiency. […] Prevention is centred around patient education. All patients should be educated on stress dosing and parenteral glucocorticoid administration. […] Patient education is the most important component in the prevention of adrenal crisis. […] An additional dose of hydrocortisone may be considered in situations of severe and prolonged psychological stress, or prolonged physical exercise. […] It is important that patients, caregivers and family members are aware of the symptoms of an impending crisis. […] Guidelines recommend that all patients should carry steroid emergency cards. […] Education of patients and partner/family members regarding symptom awareness and the correct adjustment of glucocorticoid replacement dose is imperative.
- #11 Managing Your Addison’s Disease â Symptoms & Treatment | Carle.orghttps://carle.org/conditions/addison-s-disease
There is no effective way to prevent Addisons disease. […] DO avoid stress. […] DO watch your lifestyle. Drink alcohol only in moderation. Eat a well-balanced diet with enough regular table salt. […] DO call your health care provider when you feel poorly (nausea, vomiting, fever) or feel weak and tired and have weight loss.
- #12 Adrenal crisis: prevention and management in adult patientshttps://pmc.ncbi.nlm.nih.gov/articles/PMC6566489/
Adrenal crisis is an acute life-threatening emergency contributing to the excess mortality that is reported in patients with adrenal insufficiency. […] Prevention is centred around patient education. All patients should be educated on stress dosing and parenteral glucocorticoid administration. […] Patient education is the most important component in the prevention of adrenal crisis. […] An additional dose of hydrocortisone may be considered in situations of severe and prolonged psychological stress, or prolonged physical exercise. […] It is important that patients, caregivers and family members are aware of the symptoms of an impending crisis. […] Guidelines recommend that all patients should carry steroid emergency cards. […] Education of patients and partner/family members regarding symptom awareness and the correct adjustment of glucocorticoid replacement dose is imperative.
- #13 Adrenal crisis – EMCrit Projecthttps://emcrit.org/ibcc/adrenal-crisis/
For patients with known adrenal insufficiency, steroid dose should be increased when undergoing physiologic stress to prevent the development of adrenal crisis. […] Severe stress (e.g., major surgery, severe infection) 50 mg IV hydrocortisone Q6hr may be reasonable. This represents roughly eight times the normal physiologic output of steroid. […] Moderate stress may double or triple the patient’s maintenance dose of steroid (this will be ~50-75 mg/day hydrocortisone in two or three divided doses).
- #14 Adrenal crisis – EMCrit Projecthttps://emcrit.org/ibcc/adrenal-crisis/
For patients with known adrenal insufficiency, steroid dose should be increased when undergoing physiologic stress to prevent the development of adrenal crisis. […] Severe stress (e.g., major surgery, severe infection) 50 mg IV hydrocortisone Q6hr may be reasonable. This represents roughly eight times the normal physiologic output of steroid. […] Moderate stress may double or triple the patient’s maintenance dose of steroid (this will be ~50-75 mg/day hydrocortisone in two or three divided doses).
- #15 Adrenal crisis: prevention and management in adult patientshttps://pmc.ncbi.nlm.nih.gov/articles/PMC6566489/
Adrenal crisis is an acute life-threatening emergency contributing to the excess mortality that is reported in patients with adrenal insufficiency. […] Prevention is centred around patient education. All patients should be educated on stress dosing and parenteral glucocorticoid administration. […] Patient education is the most important component in the prevention of adrenal crisis. […] An additional dose of hydrocortisone may be considered in situations of severe and prolonged psychological stress, or prolonged physical exercise. […] It is important that patients, caregivers and family members are aware of the symptoms of an impending crisis. […] Guidelines recommend that all patients should carry steroid emergency cards. […] Education of patients and partner/family members regarding symptom awareness and the correct adjustment of glucocorticoid replacement dose is imperative.
- #16 Adrenal crisis – EMCrit Projecthttps://emcrit.org/ibcc/adrenal-crisis/
For patients with known adrenal insufficiency, steroid dose should be increased when undergoing physiologic stress to prevent the development of adrenal crisis. […] Severe stress (e.g., major surgery, severe infection) 50 mg IV hydrocortisone Q6hr may be reasonable. This represents roughly eight times the normal physiologic output of steroid. […] Moderate stress may double or triple the patient’s maintenance dose of steroid (this will be ~50-75 mg/day hydrocortisone in two or three divided doses).
- #17 Adrenal Crisis: Causes, Symptoms, Diagnosis & Treatmenthttps://my.clevelandclinic.org/health/diseases/23948-adrenal-crisis
If you have an adrenal insufficiency, learn what stressors may trigger an adrenal crisis. These may include mental or emotional stress, dehydration, infection or not taking your glucocorticoid medications as prescribed by your healthcare provider. […] Surgery and pregnancy may trigger an adrenal insufficiency. Tell your healthcare provider that you have an adrenal insufficiency before any surgery. Talk to your provider if you’re planning to become pregnant. […] Carry a medical identification card, necklace or bracelet that indicates you have an adrenal insufficiency. Your identification materials should also include what type of medication you need and the exact dosage. This information can help your healthcare providers administer timely treatment. […] Regularly weigh yourself and check your blood pressure. Let your healthcare provider know if you lose weight or if your blood pressure gets too high or too low.
- #18https://www.addisonsdisease.org.uk/the-emergency-injection-for-the-treatment-of-adrenal-crisis
Provision of a hydrocortisone emergency injection kit is standard practice for the prevention of an acute adrenal crisis. […] People with Addison’s and adrenal insufficiency require an emergency injection kit (100mg hydrocortisone) for at home, when travelling and on holiday, for use in an emergency to avoid precipitating an acute adrenal crisis. […] Note: The NICE guidance includes that a minimum of two emergency injection kits should be prescribed, so spares available for travel or in case a vial shatters and becomes unusable in an adrenal crisis.
- #19 Adrenal crisis: prevention and management in adult patientshttps://pmc.ncbi.nlm.nih.gov/articles/PMC6566489/
Patients should have access to a vial of injectable hydrocortisone, e.g. 100mg of hydrocortisone sodium succinate, with appropriate needles, syringes and water for injection for reconstitution, available at all times. […] Emergency management of adrenal crisis is standardized, and patients respond well to the recommended therapy, with low mortality rates in hospitalized patients. […] Improved patient education with an emphasis on stress dosing, medical alert identification and glucocorticoid emergency kits are pivotal in reducing the prevalence of this potentially life-threatening presentation.
- #20https://www.addisonsdisease.org.uk/the-emergency-injection-for-the-treatment-of-adrenal-crisis
Provision of a hydrocortisone emergency injection kit is standard practice for the prevention of an acute adrenal crisis. […] People with Addison’s and adrenal insufficiency require an emergency injection kit (100mg hydrocortisone) for at home, when travelling and on holiday, for use in an emergency to avoid precipitating an acute adrenal crisis. […] Note: The NICE guidance includes that a minimum of two emergency injection kits should be prescribed, so spares available for travel or in case a vial shatters and becomes unusable in an adrenal crisis.
- #21https://www.addisonsdisease.org.uk/the-emergency-injection-for-the-treatment-of-adrenal-crisis
Provision of a hydrocortisone emergency injection kit is standard practice for the prevention of an acute adrenal crisis. […] People with Addison’s and adrenal insufficiency require an emergency injection kit (100mg hydrocortisone) for at home, when travelling and on holiday, for use in an emergency to avoid precipitating an acute adrenal crisis. […] Note: The NICE guidance includes that a minimum of two emergency injection kits should be prescribed, so spares available for travel or in case a vial shatters and becomes unusable in an adrenal crisis.
- #22 Adrenal Crisis: Causes, Symptoms, Diagnosis & Treatmenthttps://my.clevelandclinic.org/health/diseases/23948-adrenal-crisis
Your provider may give you an emergency shot of cortisol. They’ll teach you when and how to give yourself cortisol. Keep this medication and directions on how to use it handy at all times. Teach a family member or close friend how to give you the cortisol shot in case you’re too weak to administer it yourself. […] It’s also a good idea for you and your healthcare provider to create a plan in the event you can’t take your hydrocortisone pills because of nausea or vomiting. […] Work with your healthcare provider to identify stressors that may trigger an adrenal crisis and learn how to avoid them.
- #23 Patient education: Adrenal insufficiency (Beyond the Basics) – UpToDatehttps://www.uptodate.com/contents/adrenal-insufficiency-beyond-the-basics
Even with careful use of medications and medical monitoring, some people with adrenal insufficiency will experience adrenal crisis. As a safety measure, it is important to always carry a syringe and a vial of hydrocortisone (or another glucocorticoid). This emergency medication kit should be stored at home and at work or school and carried in a handbag or backpack. […] It is important to call the provider if there are any signs of a stomach illness with nausea, diarrhea, or vomiting. It is also important to call before any medical procedures or surgery. The provider will usually recommend temporarily increasing the glucocorticoid dose for these types of stresses. […] Most females who have primary adrenal insufficiency are able to have a healthy pregnancy, labor, and delivery. Pregnant people should be monitored by an obstetrician and endocrinologist with expertise in adrenal insufficiency.
- #24 What Is Addisonâs Disease? Symptoms, Causes, Diagnosis, Treatment, and Preventionhttps://www.everydayhealth.com/autoimmune-diseases/addisons-disease/
Theres no way to prevent Addisons disease. But there are ways to keep yourself healthy after youre diagnosed with this condition: […] Take your medications as prescribed to prevent complications. Missing even one day of your medications can be dangerous, so its a good idea to keep extra medication on you at all times. […] Have an emergency corticosteroid medication kit with you at all times to provide the hormones you need if you begin to develop emergency symptoms. These kits include injectable corticosteroids that act fast in the body. […] Carry a medical alert card or bracelet with you so emergency personnel will know how to help you if you ever experience extreme symptoms. […] Attend regularly scheduled checkups and blood draws to keeps tabs on your symptoms and hormone levels and make sure you stay healthy. You need to monitor your hormone levels carefully to avoid taking too much or too little medication.
- #25 Adrenal crisis: prevention and management in adult patientshttps://pmc.ncbi.nlm.nih.gov/articles/PMC6566489/
Adrenal crisis is an acute life-threatening emergency contributing to the excess mortality that is reported in patients with adrenal insufficiency. […] Prevention is centred around patient education. All patients should be educated on stress dosing and parenteral glucocorticoid administration. […] Patient education is the most important component in the prevention of adrenal crisis. […] An additional dose of hydrocortisone may be considered in situations of severe and prolonged psychological stress, or prolonged physical exercise. […] It is important that patients, caregivers and family members are aware of the symptoms of an impending crisis. […] Guidelines recommend that all patients should carry steroid emergency cards. […] Education of patients and partner/family members regarding symptom awareness and the correct adjustment of glucocorticoid replacement dose is imperative.
- #26 Primary adrenal insufficiency – Symptoms, diagnosis and treatment | BMJ Best Practicehttps://bestpractice.bmj.com/topics/en-gb/56
Use of a medical alert (bracelet or card) warning about their condition, and education on when to increase glucocorticoid replacement doses appropriately during surgery and during any stressful or infectious conditions, is vital to prevent potentially life-threatening adrenal crises. […] Guidelines for the management and prevention of acute adrenal insufficiency. […] Adrenal insufficiency – emergency management practice guideline.
- #27 Addison’s Disease: New Guideline Details Diagnosis and Treatment – Endocrinology Advisorhttps://www.endocrinologyadvisor.com/features/addisons-disease-new-guideline-details-diagnosis-and-treatment/
The guideline includes recommendations in 5 areas: […] Management and prevention of adrenal crisis; and […] For the prevention of adrenal crisis, the task force recommends adjustments in glucocorticoid dose according to the severity of illness or magnitude of the stressor. The guideline also emphasizes the need for patient education about medication adjustments in stressful events, and suggests that patients be equipped with a steroid emergency card or medical alert identification in order to improve management and prevention of adrenal crisis.
- #28 Addisonâs Disease: Symptoms, Causes, Treatment and Morehttps://www.health.com/addisons-disease-overview-7372029
Theres no way to prevent Addisons disease. Its typically an autoimmune disorder, which means your bodys immune system attacks its own healthy tissues. However, you can seek treatment early on if you have any symptoms to prevent complications. […] To prevent complications and manage your symptoms Addisons disease, its important to take your medications regularly and exactly as prescribed. Doing this, people with Addison’s disease can usually live a like-normal life. Your healthcare provider may suggest wearing a medical alert bracelet with the name of the condition on it and a note that you require steroids. […] Your healthcare provider may also recommend that you make certain changes to your eating habits. If you have low aldosterone, they may suggest following a high-sodium diet. And to prevent osteoporosis from high-dose corticosteroid use, they may tell you to take in enough calcium and vitamin D or even take calcium supplements.
- #29 Addison’s disease | healthdirecthttps://www.healthdirect.gov.au/addisons-disease
Addison’s disease requires life-long steroid replacement therapy. […] If you have Addison’s disease, you should have a clear plan of action from your doctor as to what to do during a stressful event like illness or injury to prevent an Addisonian crisis. […] In the case of a stressful event, you will need to take a stress dose (higher dose) of your corticosteroid medicine and may require an injection of a medicine called hydrocortisone. […] If you have Addison’s disease, consider wearing a medical alert bracelet or carrying an emergency card. You will usually need a plan from your doctor about what to do if you get sick and how to manage your steroid medicine. It is important to take your medicines as prescribed. Do not suddenly stop taking them without checking with your doctor.
- #30 Patient education: Adrenal insufficiency (Beyond the Basics) – UpToDatehttps://www.uptodate.com/contents/adrenal-insufficiency-beyond-the-basics
People with adrenal insufficiency should learn as much as possible about their condition and should be aware of early warning signs of hormone deficiency. It is important to share this information with family, friends, and any caregivers, so that they can also identify signs of trouble and be prepared to act in case of adrenal crisis. […] People with adrenal insufficiency should wear a medical alert bracelet or necklace. They should also carry an emergency medical information card that lists the names and doses of their daily medications and the health care provider and family member(s) to call in case of emergency. It is extremely important to identify early symptoms of adrenal insufficiency and adrenal crisis; your provider can talk to you about subtle symptoms that should not be ignored.
- #31 Adrenal Crisis: Causes, Symptoms, Diagnosis & Treatmenthttps://my.clevelandclinic.org/health/diseases/23948-adrenal-crisis
If you have an adrenal insufficiency, learn what stressors may trigger an adrenal crisis. These may include mental or emotional stress, dehydration, infection or not taking your glucocorticoid medications as prescribed by your healthcare provider. […] Surgery and pregnancy may trigger an adrenal insufficiency. Tell your healthcare provider that you have an adrenal insufficiency before any surgery. Talk to your provider if you’re planning to become pregnant. […] Carry a medical identification card, necklace or bracelet that indicates you have an adrenal insufficiency. Your identification materials should also include what type of medication you need and the exact dosage. This information can help your healthcare providers administer timely treatment. […] Regularly weigh yourself and check your blood pressure. Let your healthcare provider know if you lose weight or if your blood pressure gets too high or too low.
- #32 Addisonâs Disease: Symptoms, Causes, Treatment and Morehttps://www.health.com/addisons-disease-overview-7372029
Theres no way to prevent Addisons disease. Its typically an autoimmune disorder, which means your bodys immune system attacks its own healthy tissues. However, you can seek treatment early on if you have any symptoms to prevent complications. […] To prevent complications and manage your symptoms Addisons disease, its important to take your medications regularly and exactly as prescribed. Doing this, people with Addison’s disease can usually live a like-normal life. Your healthcare provider may suggest wearing a medical alert bracelet with the name of the condition on it and a note that you require steroids. […] Your healthcare provider may also recommend that you make certain changes to your eating habits. If you have low aldosterone, they may suggest following a high-sodium diet. And to prevent osteoporosis from high-dose corticosteroid use, they may tell you to take in enough calcium and vitamin D or even take calcium supplements.
- #33 Addisonâs Disease: Symptoms, Causes, Treatment and Morehttps://www.health.com/addisons-disease-overview-7372029
Theres no way to prevent Addisons disease. Its typically an autoimmune disorder, which means your bodys immune system attacks its own healthy tissues. However, you can seek treatment early on if you have any symptoms to prevent complications. […] To prevent complications and manage your symptoms Addisons disease, its important to take your medications regularly and exactly as prescribed. Doing this, people with Addison’s disease can usually live a like-normal life. Your healthcare provider may suggest wearing a medical alert bracelet with the name of the condition on it and a note that you require steroids. […] Your healthcare provider may also recommend that you make certain changes to your eating habits. If you have low aldosterone, they may suggest following a high-sodium diet. And to prevent osteoporosis from high-dose corticosteroid use, they may tell you to take in enough calcium and vitamin D or even take calcium supplements.
- #34 Addison’s Disease Symptoms and Possible Causes – Dr. Axehttps://draxe.com/health/addisons-disease/
Addisons disease can result in low aldosterone levels, which increases the need for salt. According to The National Institute of Diabetes and Digestive and Kidney Diseases, some people can benefit from following a high-sodium diet; however, its best to get advice from your doctor or a dietitian regarding how much sodium is best for you to have each day. If you do need to increase your intake, try getting sodium from healthy foods such as broths, sea vegetables and sea salt. […] To help prevent an emergency and lower risk for adrenal crisis complications, its recommended that people with Addisons disease: Visit an endocrinology specialist at least once a year, Have an annual screening for a number of autoimmune diseases, Carry a steroid emergency card, medical alert identification kit and glucocorticoid injection kit with them.
- #35https://myhealth.alberta.ca/Health/aftercareinformation/pages/conditions.aspx?hwid=ut2651
You will probably need to take medicine for the rest of your life to treat your condition and help prevent an adrenal crisis. […] Work with your doctor to create a plan for what to do when you’re sick or when your body is under stress. You may need to change the amount of medicine you take during this time. […] Don’t reduce salt in your diet. You may need to add extra salt to your food during hot and humid weather or after exercise to replace salt lost through sweating.
- #36 Managing Your Addison’s Disease â Symptoms & Treatment | Carle.orghttps://carle.org/conditions/addison-s-disease
There is no effective way to prevent Addisons disease. […] DO avoid stress. […] DO watch your lifestyle. Drink alcohol only in moderation. Eat a well-balanced diet with enough regular table salt. […] DO call your health care provider when you feel poorly (nausea, vomiting, fever) or feel weak and tired and have weight loss.
- #37 Addison Disease – Treatment Options, Management and Prevention – By Dr. Neeraj Garg | Lybratehttps://www.lybrate.com/topic/addison-disease-treatment-options-management-and-prevention/2eaab84d7fc589af55ba18613aa79c33
People diagnosed with Addisons disease are at risk of developing Addisonian crisis. Such people must be well-aware of how to tackle the condition if they are to face it. […] If you indulge in heavy workout sessions, you should take ample amount of sodium. This is also recommended when you are experiencing a stressful situation, including any infection, operation or some minor illness. You should not skip your meals or indulge in binge eating, but focus on having a well-balanced diet. You should also take plenty of healthy fluids throughout the day. Avoid exercising or doing any physically strenuous job in hot and humid weather. Also, you need to balance your active stretch of time with adequate rest. […] Taking the prescribed medications on time, and carrying a hydrocortisone kit is crucial. Also, you may carry a card stating the condition that can help during an emergency. […] Addisons disease, in most cases, cannot be cured; so, it is vital to be aware of the symptoms and the ways to manage them to avoid an emergency.
- #38 Addisonâs Disease: Symptoms, Causes, Treatment and Morehttps://www.health.com/addisons-disease-overview-7372029
Theres no way to prevent Addisons disease. Its typically an autoimmune disorder, which means your bodys immune system attacks its own healthy tissues. However, you can seek treatment early on if you have any symptoms to prevent complications. […] To prevent complications and manage your symptoms Addisons disease, its important to take your medications regularly and exactly as prescribed. Doing this, people with Addison’s disease can usually live a like-normal life. Your healthcare provider may suggest wearing a medical alert bracelet with the name of the condition on it and a note that you require steroids. […] Your healthcare provider may also recommend that you make certain changes to your eating habits. If you have low aldosterone, they may suggest following a high-sodium diet. And to prevent osteoporosis from high-dose corticosteroid use, they may tell you to take in enough calcium and vitamin D or even take calcium supplements.
- #39 Managing Your Addison’s Disease â Symptoms & Treatment | Carle.orghttps://carle.org/conditions/addison-s-disease
There is no effective way to prevent Addisons disease. […] DO avoid stress. […] DO watch your lifestyle. Drink alcohol only in moderation. Eat a well-balanced diet with enough regular table salt. […] DO call your health care provider when you feel poorly (nausea, vomiting, fever) or feel weak and tired and have weight loss.
- #40 Addison Disease – Treatment Options, Management and Prevention – By Dr. Neeraj Garg | Lybratehttps://www.lybrate.com/topic/addison-disease-treatment-options-management-and-prevention/2eaab84d7fc589af55ba18613aa79c33
People diagnosed with Addisons disease are at risk of developing Addisonian crisis. Such people must be well-aware of how to tackle the condition if they are to face it. […] If you indulge in heavy workout sessions, you should take ample amount of sodium. This is also recommended when you are experiencing a stressful situation, including any infection, operation or some minor illness. You should not skip your meals or indulge in binge eating, but focus on having a well-balanced diet. You should also take plenty of healthy fluids throughout the day. Avoid exercising or doing any physically strenuous job in hot and humid weather. Also, you need to balance your active stretch of time with adequate rest. […] Taking the prescribed medications on time, and carrying a hydrocortisone kit is crucial. Also, you may carry a card stating the condition that can help during an emergency. […] Addisons disease, in most cases, cannot be cured; so, it is vital to be aware of the symptoms and the ways to manage them to avoid an emergency.
- #41 Addison Disease – Treatment Options, Management and Prevention – By Dr. Neeraj Garg | Lybratehttps://www.lybrate.com/topic/addison-disease-treatment-options-management-and-prevention/2eaab84d7fc589af55ba18613aa79c33
People diagnosed with Addisons disease are at risk of developing Addisonian crisis. Such people must be well-aware of how to tackle the condition if they are to face it. […] If you indulge in heavy workout sessions, you should take ample amount of sodium. This is also recommended when you are experiencing a stressful situation, including any infection, operation or some minor illness. You should not skip your meals or indulge in binge eating, but focus on having a well-balanced diet. You should also take plenty of healthy fluids throughout the day. Avoid exercising or doing any physically strenuous job in hot and humid weather. Also, you need to balance your active stretch of time with adequate rest. […] Taking the prescribed medications on time, and carrying a hydrocortisone kit is crucial. Also, you may carry a card stating the condition that can help during an emergency. […] Addisons disease, in most cases, cannot be cured; so, it is vital to be aware of the symptoms and the ways to manage them to avoid an emergency.
- #42 Addison’s Disease Symptoms and Possible Causes – Dr. Axehttps://draxe.com/health/addisons-disease/
Addisons disease can result in low aldosterone levels, which increases the need for salt. According to The National Institute of Diabetes and Digestive and Kidney Diseases, some people can benefit from following a high-sodium diet; however, its best to get advice from your doctor or a dietitian regarding how much sodium is best for you to have each day. If you do need to increase your intake, try getting sodium from healthy foods such as broths, sea vegetables and sea salt. […] To help prevent an emergency and lower risk for adrenal crisis complications, its recommended that people with Addisons disease: Visit an endocrinology specialist at least once a year, Have an annual screening for a number of autoimmune diseases, Carry a steroid emergency card, medical alert identification kit and glucocorticoid injection kit with them.
- #43 Addison’s Disease Symptoms and Possible Causes – Dr. Axehttps://draxe.com/health/addisons-disease/
Addisons disease can result in low aldosterone levels, which increases the need for salt. According to The National Institute of Diabetes and Digestive and Kidney Diseases, some people can benefit from following a high-sodium diet; however, its best to get advice from your doctor or a dietitian regarding how much sodium is best for you to have each day. If you do need to increase your intake, try getting sodium from healthy foods such as broths, sea vegetables and sea salt. […] To help prevent an emergency and lower risk for adrenal crisis complications, its recommended that people with Addisons disease: Visit an endocrinology specialist at least once a year, Have an annual screening for a number of autoimmune diseases, Carry a steroid emergency card, medical alert identification kit and glucocorticoid injection kit with them.
- #44 Azthena logo with the word Azthenahttps://www.news-medical.net/health/Addisons-Disease-Treatments.aspx
Certain steps may be taken to prevent attacks of Addisonian crisis. These include:- Following up regular appointments with the Endocrinologist every 6 to 12 months. […] Medication needs to be taken at the same time each day. […] Medical alert bracelets or necklace can help identify a patient with Addisons disease. This can help identify patients who meet an accident need cortisol to cope with the added stress, failing which they may develop Addisonian crisis. […] Medications (corticosteroids) need to be increased and adjusted in stressful conditions like an illness or infection with fever, before an operation or medical procedure, before strenouous exercise, before a dental procedure and after an accident. This helps the body cope with the additional stress.
- #45 Addison’s Disease Symptoms and Possible Causes – Dr. Axehttps://draxe.com/health/addisons-disease/
Addisons disease can result in low aldosterone levels, which increases the need for salt. According to The National Institute of Diabetes and Digestive and Kidney Diseases, some people can benefit from following a high-sodium diet; however, its best to get advice from your doctor or a dietitian regarding how much sodium is best for you to have each day. If you do need to increase your intake, try getting sodium from healthy foods such as broths, sea vegetables and sea salt. […] To help prevent an emergency and lower risk for adrenal crisis complications, its recommended that people with Addisons disease: Visit an endocrinology specialist at least once a year, Have an annual screening for a number of autoimmune diseases, Carry a steroid emergency card, medical alert identification kit and glucocorticoid injection kit with them.
- #46 Adrenal Crisis: Causes, Symptoms, Diagnosis & Treatmenthttps://my.clevelandclinic.org/health/diseases/23948-adrenal-crisis
If you have an adrenal insufficiency, learn what stressors may trigger an adrenal crisis. These may include mental or emotional stress, dehydration, infection or not taking your glucocorticoid medications as prescribed by your healthcare provider. […] Surgery and pregnancy may trigger an adrenal insufficiency. Tell your healthcare provider that you have an adrenal insufficiency before any surgery. Talk to your provider if you’re planning to become pregnant. […] Carry a medical identification card, necklace or bracelet that indicates you have an adrenal insufficiency. Your identification materials should also include what type of medication you need and the exact dosage. This information can help your healthcare providers administer timely treatment. […] Regularly weigh yourself and check your blood pressure. Let your healthcare provider know if you lose weight or if your blood pressure gets too high or too low.
- #47 What Is Addisonâs Disease? Symptoms, Causes, Diagnosis, Treatment, and Preventionhttps://www.everydayhealth.com/autoimmune-diseases/addisons-disease/
Theres no way to prevent Addisons disease. But there are ways to keep yourself healthy after youre diagnosed with this condition: […] Take your medications as prescribed to prevent complications. Missing even one day of your medications can be dangerous, so its a good idea to keep extra medication on you at all times. […] Have an emergency corticosteroid medication kit with you at all times to provide the hormones you need if you begin to develop emergency symptoms. These kits include injectable corticosteroids that act fast in the body. […] Carry a medical alert card or bracelet with you so emergency personnel will know how to help you if you ever experience extreme symptoms. […] Attend regularly scheduled checkups and blood draws to keeps tabs on your symptoms and hormone levels and make sure you stay healthy. You need to monitor your hormone levels carefully to avoid taking too much or too little medication.
- #48 Patient education: Adrenal insufficiency (Beyond the Basics) – UpToDatehttps://www.uptodate.com/contents/adrenal-insufficiency-beyond-the-basics
Even with careful use of medications and medical monitoring, some people with adrenal insufficiency will experience adrenal crisis. As a safety measure, it is important to always carry a syringe and a vial of hydrocortisone (or another glucocorticoid). This emergency medication kit should be stored at home and at work or school and carried in a handbag or backpack. […] It is important to call the provider if there are any signs of a stomach illness with nausea, diarrhea, or vomiting. It is also important to call before any medical procedures or surgery. The provider will usually recommend temporarily increasing the glucocorticoid dose for these types of stresses. […] Most females who have primary adrenal insufficiency are able to have a healthy pregnancy, labor, and delivery. Pregnant people should be monitored by an obstetrician and endocrinologist with expertise in adrenal insufficiency.
- #49 Treatment of Addisonâs disease during pregnancy in: Endocrinology, Diabetes & Metabolism Case Reports Volume 2018 Issue 1 (2018)https://edm.bioscientifica.com/view/journals/edm/2018/1/EDM17-0179.xml
Addisons disease, or primary adrenocortical insufficiency, is a long-term, potentially severe, rare endocrine disorder. In pregnancy, it is even rarer. […] Pregnant patients with Addisons disease should be monitored during gestation and in the peripartum period by multidisciplinary teams. Adjustments in glucocorticoid and mineralocorticoid replacement therapy are often necessary, and monitoring should be based mainly on clinical findings, which becomes increasingly difficult during pregnancy. Patient education and specialized monitoring are key to avoiding complications from under- or over-replacement therapy in this period. […] An increase in glucocorticoid replacement dose is expected to be necessary during pregnancy in a woman with Addisons disease. Patient education regarding steroid cover and symptoms of acute adrenal crisis are fundamental. Monitoring in this period is challenging and remains mainly clinical. The increase in hydrocortisone dose often obviates the need to increase fludrocortisone dose.
- #50 Treatment of Addisonâs disease during pregnancy in: Endocrinology, Diabetes & Metabolism Case Reports Volume 2018 Issue 1 (2018)https://edm.bioscientifica.com/view/journals/edm/2018/1/EDM17-0179.xml
Addisons disease, or primary adrenocortical insufficiency, is a long-term, potentially severe, rare endocrine disorder. In pregnancy, it is even rarer. […] Pregnant patients with Addisons disease should be monitored during gestation and in the peripartum period by multidisciplinary teams. Adjustments in glucocorticoid and mineralocorticoid replacement therapy are often necessary, and monitoring should be based mainly on clinical findings, which becomes increasingly difficult during pregnancy. Patient education and specialized monitoring are key to avoiding complications from under- or over-replacement therapy in this period. […] An increase in glucocorticoid replacement dose is expected to be necessary during pregnancy in a woman with Addisons disease. Patient education regarding steroid cover and symptoms of acute adrenal crisis are fundamental. Monitoring in this period is challenging and remains mainly clinical. The increase in hydrocortisone dose often obviates the need to increase fludrocortisone dose.
- #51 Treatment of Addisonâs disease during pregnancy in: Endocrinology, Diabetes & Metabolism Case Reports Volume 2018 Issue 1 (2018)https://edm.bioscientifica.com/view/journals/edm/2018/1/EDM17-0179.xml
Addisons disease, or primary adrenocortical insufficiency, is a long-term, potentially severe, rare endocrine disorder. In pregnancy, it is even rarer. […] Pregnant patients with Addisons disease should be monitored during gestation and in the peripartum period by multidisciplinary teams. Adjustments in glucocorticoid and mineralocorticoid replacement therapy are often necessary, and monitoring should be based mainly on clinical findings, which becomes increasingly difficult during pregnancy. Patient education and specialized monitoring are key to avoiding complications from under- or over-replacement therapy in this period. […] An increase in glucocorticoid replacement dose is expected to be necessary during pregnancy in a woman with Addisons disease. Patient education regarding steroid cover and symptoms of acute adrenal crisis are fundamental. Monitoring in this period is challenging and remains mainly clinical. The increase in hydrocortisone dose often obviates the need to increase fludrocortisone dose.
- #52 Treatment of Addisonâs disease during pregnancy in: Endocrinology, Diabetes & Metabolism Case Reports Volume 2018 Issue 1 (2018)https://edm.bioscientifica.com/view/journals/edm/2018/1/EDM17-0179.xml
The objective of the follow-up of a woman with AD during pregnancy is to keep the replacement therapy in doses that assure the mother and fetus health, avoiding effects of over-treatment (e.g. gestational diabetes, excessive weight gain, arterial hypertension) and of under-treatment (low birth weight, adrenal crisis in the mother, electrolyte imbalance). […] Delivery must be planned and monitored by a multidisciplinary team. Most deliveries occur without complications when pregnancy was carefully followed and treatment optimized. The Endocrinologist should provide the obstetric team with a written therapeutic plan regarding intravenous glucocorticoid coverage, which must be started before the active phase of labor initial bolus of 100mg hydrocortisone followed by continuous perfusion 200-300mg/24h.
- #53 Treatment of Addisonâs disease during pregnancy in: Endocrinology, Diabetes & Metabolism Case Reports Volume 2018 Issue 1 (2018)https://edm.bioscientifica.com/view/journals/edm/2018/1/EDM17-0179.xml
Addisons disease, or primary adrenocortical insufficiency, is a long-term, potentially severe, rare endocrine disorder. In pregnancy, it is even rarer. […] Pregnant patients with Addisons disease should be monitored during gestation and in the peripartum period by multidisciplinary teams. Adjustments in glucocorticoid and mineralocorticoid replacement therapy are often necessary, and monitoring should be based mainly on clinical findings, which becomes increasingly difficult during pregnancy. Patient education and specialized monitoring are key to avoiding complications from under- or over-replacement therapy in this period. […] An increase in glucocorticoid replacement dose is expected to be necessary during pregnancy in a woman with Addisons disease. Patient education regarding steroid cover and symptoms of acute adrenal crisis are fundamental. Monitoring in this period is challenging and remains mainly clinical. The increase in hydrocortisone dose often obviates the need to increase fludrocortisone dose.
- #54 Addison’s disease – Symptoms and causes – Mayo Clinichttps://www.mayoclinic.org/diseases-conditions/addisons-disease/symptoms-causes/syc-20350293
Addison’s disease can’t be prevented. But you can take steps to lower the risk of adrenal crisis: […] Talk with your healthcare professional if you always feel tired or weak or are losing weight without trying. Ask if you should get tested for adrenal insufficiency. […] If you have Addison’s disease, ask your healthcare professional what to do when you’re sick. You’ll likely need to learn how to adjust the amount of medicine that you take. You also may need to take the medicine as a shot. […] If you become very sick, go to an emergency room. This is crucial if you’re vomiting and you can’t take your medicine. […] Some people with Addison’s disease worry about serious side effects from corticosteroid medicines. But people with Addison’s disease aren’t likely to get the side effects of high-dose corticosteroids used to treat many other diseases. That’s because the dose prescribed is much lower and only replaces the amount that’s missing. […] If you take corticosteroids, follow up with your healthcare professional regularly to make sure your dose is not too high.
- #55 Addison’s disease | Beacon Health Systemhttps://www.beaconhealthsystem.org/library/diseases-and-conditions/addisons-disease?content_id=CON-20154557
Addison’s disease can’t be prevented. But you can take steps to lower the risk of adrenal crisis: […] Talk with your healthcare professional if you always feel tired or weak or are losing weight without trying. Ask if you should get tested for adrenal insufficiency. […] If you have Addison’s disease, ask your healthcare professional what to do when you’re sick. You’ll likely need to learn how to adjust the amount of medicine that you take. You also may need to take the medicine as a shot. […] If you become very sick, go to an emergency room. This is crucial if you’re vomiting and you can’t take your medicine.
- #56 Managing Your Addison’s Disease â Symptoms & Treatment | Carle.orghttps://carle.org/conditions/addison-s-disease
There is no effective way to prevent Addisons disease. […] DO avoid stress. […] DO watch your lifestyle. Drink alcohol only in moderation. Eat a well-balanced diet with enough regular table salt. […] DO call your health care provider when you feel poorly (nausea, vomiting, fever) or feel weak and tired and have weight loss.
- #57 Patient education: Adrenal insufficiency (Beyond the Basics) – UpToDatehttps://www.uptodate.com/contents/adrenal-insufficiency-beyond-the-basics
Even with careful use of medications and medical monitoring, some people with adrenal insufficiency will experience adrenal crisis. As a safety measure, it is important to always carry a syringe and a vial of hydrocortisone (or another glucocorticoid). This emergency medication kit should be stored at home and at work or school and carried in a handbag or backpack. […] It is important to call the provider if there are any signs of a stomach illness with nausea, diarrhea, or vomiting. It is also important to call before any medical procedures or surgery. The provider will usually recommend temporarily increasing the glucocorticoid dose for these types of stresses. […] Most females who have primary adrenal insufficiency are able to have a healthy pregnancy, labor, and delivery. Pregnant people should be monitored by an obstetrician and endocrinologist with expertise in adrenal insufficiency.
- #58 Addison’s disease – Symptoms and causes – Mayo Clinichttps://www.mayoclinic.org/diseases-conditions/addisons-disease/symptoms-causes/syc-20350293
Addison’s disease can’t be prevented. But you can take steps to lower the risk of adrenal crisis: […] Talk with your healthcare professional if you always feel tired or weak or are losing weight without trying. Ask if you should get tested for adrenal insufficiency. […] If you have Addison’s disease, ask your healthcare professional what to do when you’re sick. You’ll likely need to learn how to adjust the amount of medicine that you take. You also may need to take the medicine as a shot. […] If you become very sick, go to an emergency room. This is crucial if you’re vomiting and you can’t take your medicine. […] Some people with Addison’s disease worry about serious side effects from corticosteroid medicines. But people with Addison’s disease aren’t likely to get the side effects of high-dose corticosteroids used to treat many other diseases. That’s because the dose prescribed is much lower and only replaces the amount that’s missing. […] If you take corticosteroids, follow up with your healthcare professional regularly to make sure your dose is not too high.
- #59 Addison’s disease | Beacon Health Systemhttps://www.beaconhealthsystem.org/library/diseases-and-conditions/addisons-disease?content_id=CON-20154557
Addison’s disease can’t be prevented. But you can take steps to lower the risk of adrenal crisis: […] Talk with your healthcare professional if you always feel tired or weak or are losing weight without trying. Ask if you should get tested for adrenal insufficiency. […] If you have Addison’s disease, ask your healthcare professional what to do when you’re sick. You’ll likely need to learn how to adjust the amount of medicine that you take. You also may need to take the medicine as a shot. […] If you become very sick, go to an emergency room. This is crucial if you’re vomiting and you can’t take your medicine.
- #60 Addison’s disease – Symptoms and causes – Mayo Clinichttps://www.mayoclinic.org/diseases-conditions/addisons-disease/symptoms-causes/syc-20350293
Addison’s disease can’t be prevented. But you can take steps to lower the risk of adrenal crisis: […] Talk with your healthcare professional if you always feel tired or weak or are losing weight without trying. Ask if you should get tested for adrenal insufficiency. […] If you have Addison’s disease, ask your healthcare professional what to do when you’re sick. You’ll likely need to learn how to adjust the amount of medicine that you take. You also may need to take the medicine as a shot. […] If you become very sick, go to an emergency room. This is crucial if you’re vomiting and you can’t take your medicine. […] Some people with Addison’s disease worry about serious side effects from corticosteroid medicines. But people with Addison’s disease aren’t likely to get the side effects of high-dose corticosteroids used to treat many other diseases. That’s because the dose prescribed is much lower and only replaces the amount that’s missing. […] If you take corticosteroids, follow up with your healthcare professional regularly to make sure your dose is not too high.
- #61 Addison’s disease | Beacon Health Systemhttps://www.beaconhealthsystem.org/library/diseases-and-conditions/addisons-disease?content_id=CON-20154557
Addison’s disease can’t be prevented. But you can take steps to lower the risk of adrenal crisis: […] Talk with your healthcare professional if you always feel tired or weak or are losing weight without trying. Ask if you should get tested for adrenal insufficiency. […] If you have Addison’s disease, ask your healthcare professional what to do when you’re sick. You’ll likely need to learn how to adjust the amount of medicine that you take. You also may need to take the medicine as a shot. […] If you become very sick, go to an emergency room. This is crucial if you’re vomiting and you can’t take your medicine.
- #62 Addison’s disease – Symptoms and causes – Mayo Clinichttps://www.mayoclinic.org/diseases-conditions/addisons-disease/symptoms-causes/syc-20350293
Addison’s disease can’t be prevented. But you can take steps to lower the risk of adrenal crisis: […] Talk with your healthcare professional if you always feel tired or weak or are losing weight without trying. Ask if you should get tested for adrenal insufficiency. […] If you have Addison’s disease, ask your healthcare professional what to do when you’re sick. You’ll likely need to learn how to adjust the amount of medicine that you take. You also may need to take the medicine as a shot. […] If you become very sick, go to an emergency room. This is crucial if you’re vomiting and you can’t take your medicine. […] Some people with Addison’s disease worry about serious side effects from corticosteroid medicines. But people with Addison’s disease aren’t likely to get the side effects of high-dose corticosteroids used to treat many other diseases. That’s because the dose prescribed is much lower and only replaces the amount that’s missing. […] If you take corticosteroids, follow up with your healthcare professional regularly to make sure your dose is not too high.
- #63 Addison’s disease | Beacon Health Systemhttps://www.beaconhealthsystem.org/library/diseases-and-conditions/addisons-disease?content_id=CON-20154557
Addison’s disease can’t be prevented. But you can take steps to lower the risk of adrenal crisis: […] Talk with your healthcare professional if you always feel tired or weak or are losing weight without trying. Ask if you should get tested for adrenal insufficiency. […] If you have Addison’s disease, ask your healthcare professional what to do when you’re sick. You’ll likely need to learn how to adjust the amount of medicine that you take. You also may need to take the medicine as a shot. […] If you become very sick, go to an emergency room. This is crucial if you’re vomiting and you can’t take your medicine.
- #64 What May Be the Cause of Iatrogenic Addison’s? Key Prevention & Care Tips | Maggie Yu MD, IFMCPhttps://drmaggieyu.com/blog/what-may-be-the-cause-of-iatrogenic-addisons-key-prevention-care-tips/
Steroid therapy, particularly when prolonged, can lead to suppression of the adrenal glands, affecting cortisol production and ACTH response, potentially contributing to Addison disease. […] Dose management, duration, and tapering are key to minimizing the risk of iatrogenic Addisons disease, particularly in patients with primary adrenal insufficiency or adrenal hypoplasia to prevent an adrenal crisis. […] The longer and higher dose of steroids you use, the more your adrenals may become suppressed, potentially affecting cortisol and ACTH levels, which is a concern for patients with Addisons disease. […] Stopping steroids suddenly can trigger an adrenal crisis; the taper must be slow and steady to prevent cortisol imbalance and manage adrenal insufficiency, ensuring ACTH levels remain stable.
- #65 What May Be the Cause of Iatrogenic Addison’s? Key Prevention & Care Tips | Maggie Yu MD, IFMCPhttps://drmaggieyu.com/blog/what-may-be-the-cause-of-iatrogenic-addisons-key-prevention-care-tips/
Steroid therapy, particularly when prolonged, can lead to suppression of the adrenal glands, affecting cortisol production and ACTH response, potentially contributing to Addison disease. […] Dose management, duration, and tapering are key to minimizing the risk of iatrogenic Addisons disease, particularly in patients with primary adrenal insufficiency or adrenal hypoplasia to prevent an adrenal crisis. […] The longer and higher dose of steroids you use, the more your adrenals may become suppressed, potentially affecting cortisol and ACTH levels, which is a concern for patients with Addisons disease. […] Stopping steroids suddenly can trigger an adrenal crisis; the taper must be slow and steady to prevent cortisol imbalance and manage adrenal insufficiency, ensuring ACTH levels remain stable.
- #66 What May Be the Cause of Iatrogenic Addison’s? Key Prevention & Care Tips | Maggie Yu MD, IFMCPhttps://drmaggieyu.com/blog/what-may-be-the-cause-of-iatrogenic-addisons-key-prevention-care-tips/
Steroid therapy, particularly when prolonged, can lead to suppression of the adrenal glands, affecting cortisol production and ACTH response, potentially contributing to Addison disease. […] Dose management, duration, and tapering are key to minimizing the risk of iatrogenic Addisons disease, particularly in patients with primary adrenal insufficiency or adrenal hypoplasia to prevent an adrenal crisis. […] The longer and higher dose of steroids you use, the more your adrenals may become suppressed, potentially affecting cortisol and ACTH levels, which is a concern for patients with Addisons disease. […] Stopping steroids suddenly can trigger an adrenal crisis; the taper must be slow and steady to prevent cortisol imbalance and manage adrenal insufficiency, ensuring ACTH levels remain stable.
- #67 What May Be the Cause of Iatrogenic Addison’s? Key Prevention & Care Tips | Maggie Yu MD, IFMCPhttps://drmaggieyu.com/blog/what-may-be-the-cause-of-iatrogenic-addisons-key-prevention-care-tips/
Steroid therapy, particularly when prolonged, can lead to suppression of the adrenal glands, affecting cortisol production and ACTH response, potentially contributing to Addison disease. […] Dose management, duration, and tapering are key to minimizing the risk of iatrogenic Addisons disease, particularly in patients with primary adrenal insufficiency or adrenal hypoplasia to prevent an adrenal crisis. […] The longer and higher dose of steroids you use, the more your adrenals may become suppressed, potentially affecting cortisol and ACTH levels, which is a concern for patients with Addisons disease. […] Stopping steroids suddenly can trigger an adrenal crisis; the taper must be slow and steady to prevent cortisol imbalance and manage adrenal insufficiency, ensuring ACTH levels remain stable.
- #68 Addison’s Disease in Dogs: What You Need to Knowhttps://www.akc.org/expert-advice/health/addisons-disease/
Addison disease is not usually preventable. The exception to this is a medication-induced Addisonian crisis. If your dog is on the Cushings disease medications mitotane or trilostane, make sure that you are aware of the symptoms of Addisons disease in dogs, as an accidental overdose could lead to a crisis. Keep these medications out of reach of your dog at all times, and make sure you monitor your dogs medications carefully. […] Sometimes a rapid withdrawal of a drug like prednisone can cause Addisons. Following your veterinarians instructions about your dogs medication is the best way to prevent serious complications like Addisons disease.
- #69 An Overview of Addison Disease – Clinical Advisorhttps://www.clinicaladvisor.com/features/an-overview-of-addison-disease/
A key factor in the treatment of AD is the prevention of adrenal crisis. Steroid safety has been reported as the single most important intervention resulting in the reduction of adrenal crisis in patients with established AD. Patients should be well educated on the possible risks of non-compliance with hydrocortisone therapy and the sick day rule. In normal physiology, during periods of illness, severe psychologic stress, or surgery, cortisol rises in response to the stress the body is undergoing. In patients with AD, this normal rise in cortisol must be replicated by increasing hydrocortisone dosages. It is recommended that patients double their dosage of hydrocortisone during these high-stress periods to prevent adrenal crisis. […] […] When adjusting hydrocortisone therapy, there is potential for dual-release or modified-release formulations to be used. These formulations attempt to mimic the physiologic release of cortisol more closely, improving patient quality of life. By switching to dual-release hydrocortisone therapy, many patients report feeling better, having more energy, and seeing an overall improvement in their quality of life compared to conventional hydrocortisone therapy. However, dose adjustments can be difficult with fixed-dose dual-release hydrocortisone. It is currently only recommended for adult patients, and there is limited access to this formulation. […]
- #70 An Overview of Addison Disease – Clinical Advisorhttps://www.clinicaladvisor.com/features/an-overview-of-addison-disease/
A key factor in the treatment of AD is the prevention of adrenal crisis. Steroid safety has been reported as the single most important intervention resulting in the reduction of adrenal crisis in patients with established AD. Patients should be well educated on the possible risks of non-compliance with hydrocortisone therapy and the sick day rule. In normal physiology, during periods of illness, severe psychologic stress, or surgery, cortisol rises in response to the stress the body is undergoing. In patients with AD, this normal rise in cortisol must be replicated by increasing hydrocortisone dosages. It is recommended that patients double their dosage of hydrocortisone during these high-stress periods to prevent adrenal crisis. […] […] When adjusting hydrocortisone therapy, there is potential for dual-release or modified-release formulations to be used. These formulations attempt to mimic the physiologic release of cortisol more closely, improving patient quality of life. By switching to dual-release hydrocortisone therapy, many patients report feeling better, having more energy, and seeing an overall improvement in their quality of life compared to conventional hydrocortisone therapy. However, dose adjustments can be difficult with fixed-dose dual-release hydrocortisone. It is currently only recommended for adult patients, and there is limited access to this formulation. […]
- #71 Treatment of Addisonâs disease during pregnancy in: Endocrinology, Diabetes & Metabolism Case Reports Volume 2018 Issue 1 (2018)https://edm.bioscientifica.com/view/journals/edm/2018/1/EDM17-0179.xml
The objective of the follow-up of a woman with AD during pregnancy is to keep the replacement therapy in doses that assure the mother and fetus health, avoiding effects of over-treatment (e.g. gestational diabetes, excessive weight gain, arterial hypertension) and of under-treatment (low birth weight, adrenal crisis in the mother, electrolyte imbalance). […] Delivery must be planned and monitored by a multidisciplinary team. Most deliveries occur without complications when pregnancy was carefully followed and treatment optimized. The Endocrinologist should provide the obstetric team with a written therapeutic plan regarding intravenous glucocorticoid coverage, which must be started before the active phase of labor initial bolus of 100mg hydrocortisone followed by continuous perfusion 200-300mg/24h.
- #72 Addison’s disease – Symptoms and causes – Mayo Clinichttps://www.mayoclinic.org/diseases-conditions/addisons-disease/symptoms-causes/syc-20350293
Addison’s disease can’t be prevented. But you can take steps to lower the risk of adrenal crisis: […] Talk with your healthcare professional if you always feel tired or weak or are losing weight without trying. Ask if you should get tested for adrenal insufficiency. […] If you have Addison’s disease, ask your healthcare professional what to do when you’re sick. You’ll likely need to learn how to adjust the amount of medicine that you take. You also may need to take the medicine as a shot. […] If you become very sick, go to an emergency room. This is crucial if you’re vomiting and you can’t take your medicine. […] Some people with Addison’s disease worry about serious side effects from corticosteroid medicines. But people with Addison’s disease aren’t likely to get the side effects of high-dose corticosteroids used to treat many other diseases. That’s because the dose prescribed is much lower and only replaces the amount that’s missing. […] If you take corticosteroids, follow up with your healthcare professional regularly to make sure your dose is not too high.
- #73 Adrenal crisis: prevention and management in adult patientshttps://pmc.ncbi.nlm.nih.gov/articles/PMC6566489/
Patients should have access to a vial of injectable hydrocortisone, e.g. 100mg of hydrocortisone sodium succinate, with appropriate needles, syringes and water for injection for reconstitution, available at all times. […] Emergency management of adrenal crisis is standardized, and patients respond well to the recommended therapy, with low mortality rates in hospitalized patients. […] Improved patient education with an emphasis on stress dosing, medical alert identification and glucocorticoid emergency kits are pivotal in reducing the prevalence of this potentially life-threatening presentation.
- #74 Addison’s Disease: What It Is, Causes, Symptoms & Treatmenthttps://my.clevelandclinic.org/health/diseases/15095-addisons-disease
Unfortunately, theres nothing you can do to prevent Addisons disease. […] The prognosis for Addisons disease is generally good. Although people who have Addisons disease will need to take medicine for the rest of their lives, they can live normal, healthy lives.
- #75 Addison’s Disease: What It Is, Causes, Symptoms & Treatmenthttps://my.clevelandclinic.org/health/diseases/15095-addisons-disease
Unfortunately, theres nothing you can do to prevent Addisons disease. […] The prognosis for Addisons disease is generally good. Although people who have Addisons disease will need to take medicine for the rest of their lives, they can live normal, healthy lives.