Materiały źródłowe

• #1 Management and prognosis of gastrinoma (Zollinger-Ellison syndrome) – UpToDate

  https://www.uptodate.com/contents/management-and-prognosis-of-gastrinoma-zollinger-ellison-syndrome

  Gastrinomas are duodenal or pancreatic neuroendocrine tumors (NETs) that hypersecrete gastrin and lead to Zollinger-Ellison syndrome (ZES). ZES is the clinical syndrome of gastric acid hypersecretion caused by the gastrinoma that results in severe peptic ulcer disease, abdominal pain, and diarrhea. […] For patients with gastrinoma and ZES, the goals of therapy are control of the clinical symptoms and complications resulting from the tumor’s autonomous secretion of the hormone gastrin (ie, ZES) and control of the tumor burden itself (ie, the gastrinoma). […] Pharmacologic acid-suppressive therapy is the standard of care for most patients with gastrinoma and ZES as part of the multiple endocrine neoplasia type 1 (MEN1) syndrome. By contrast, many patients with localized sporadic gastrinoma are candidates for surgical therapy in addition to pharmacologic therapy. Successful resection of sporadic gastrinomas both reduces the risk of eventual morbidity and death from metastatic spread of the tumor and either decreases or eliminates the need for pharmacologic acid-suppressive therapy for the associated ZES.

• #2 Zollinger-Ellison Syndrome – Endocrine Surgery | UCLA Health

  https://www.uclahealth.org/medical-services/surgery/endocrine-surgery/patient-resources/patient-education/endocrine-surgery-encyclopedia/zollinger-ellison-syndrome

  Zollinger-Ellison syndrome is a condition caused by abnormal production of the hormone gastrin. A small tumor (gastinoma) in the pancreas or small intestine produces the high levels of gastrin in the blood. […] Patients with Zollinger-Ellison syndrome may experience abdominal pain and diarrhea. […] A class of acid-suppressing medications called proton pump inhibitors (for example, omeprazole, lansoprazole) is now the first choice of treatment of Zollinger-Ellison syndrome. These drugs dramatically reduce acid production by the stomach, and promote healing of ulcers in the stomach and small bowel. They also provide relief of abdominal pain and diarrhea. […] Surgical removal of a single gastrinoma may be attempted if there is no evidence that it has spread to other organs (such as lymph nodes or the liver).

• #3

  https://journals.lww.com/ajg/fulltext/2021/10001/s3070_zollinger_ellison_syndrome__a_fasting_serum.3074.aspx

  Zollinger-Ellison syndrome (ZES) is a rare condition with only 1-3 cases a year per million people due to gastrinomas causing refractory peptic ulcer disease (PUD). Diagnosis presents a challenge to clinicians given widespread use of proton pump inhibitor (PPI) therapy that masks the underlying disease process by controlling symptoms and leads to an average delay in diagnosis of 4-6 years. Definitive treatment requires prompt localization and removal prior to complications of PUD and metastatic spread. […] To ensure prompt diagnosis and high-quality care, a high index of clinical suspicion is warranted in patients with multiple ulcers and mildly elevated FSG. Recent evidence has shown that roughly two-thirds of ZES cases present with FSG 10-fold increase of normal values. This case illustrates the importance of utilizing additional testing beyond FSG in patients with refractory PUD.

• #4 Zollinger-Ellison syndrome – Diagnosis and treatment – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/zollinger-ellison-syndrome/diagnosis-treatment/drc-20379046

  Treatment of Zollinger-Ellison syndrome focuses on treating the hormone-secreting tumors as well as the ulcers they cause. […] Excess acid production can almost always be controlled. Medicines known as proton pump inhibitors are the first line of treatment. These are effective medicines for controlling acid production in Zollinger-Ellison syndrome. […] Proton pump inhibitors are powerful acid-reducing medicines. They work by blocking the action of the tiny „pumps” within acid-secreting cells. Commonly prescribed medicines include lansoprazole (Prevacid), omeprazole (Prilosec, Zegerid), pantoprazole (Protonix), rabeprazole (Aciphex) and esomeprazole (Nexium). Talk with your care professional about the risks of taking these medicines long term. […] Octreotide (Sandostatin), a medicine similar to the hormone somatostatin, may counteract the effects of gastrin and be helpful for some people.

• #5 Zollinger-Ellison Syndrome: Symptoms & Treatment

  https://my.clevelandclinic.org/health/diseases/17960-zollinger-ellison-syndrome

  Zollinger-Ellison syndrome may not cause symptoms. When it does, symptoms may include: […] Your treatment will depend on your symptoms and whether the gastrinomas are cancerous or noncancerous. Treatment options include medication, surgery and cancer therapy. […] Proton pump inhibitors (PPIs) are the most common medication for Zollinger-Ellison syndrome. Proton pump inhibitors reduce the amount of gastric acid your stomach produces. […] Your provider may recommend surgery to remove the tumor. Surgeries to remove gastrinoma tumors include: […] Surgery to remove cancerous gastrinomas may cure the condition. But a cure depends on removing all cancerous cells in your body. If surgery is successful, you’ll need to take medication to manage gastric acid for the rest of your life. […] Most people will always need medication to reduce gastric acid. Zollinger-Ellison syndrome happens because you have gastrinoma tumors. Most of these tumors are cancerous. If you have cancerous tumors, you’ll need follow-up care to confirm the tumors haven’t come back. […] You should contact your provider if Zollinger-Ellison symptoms get worse after treatment or come back.

• #6 Zollinger-Ellison syndrome | Health Library | Memorial Health System

  https://www.mhsystem.org/health-library/con-20379029/

  Zollinger-Ellison syndrome is a condition in which one or more tumors grow in the pancreas or small intestine. The tumors, called gastrinomas, produce large amounts of the hormone gastrin. Gastrin causes the stomach to produce too much acid, which leads to peptic ulcers. High gastrin levels also can cause diarrhea, belly pain and other symptoms. […] Treatment of Zollinger-Ellison syndrome focuses on treating the hormone-secreting tumors as well as the ulcers they cause. […] Excess acid production can almost always be controlled. Medicines known as proton pump inhibitors are the first line of treatment. These are effective medicines for controlling acid production in Zollinger-Ellison syndrome. […] Proton pump inhibitors are powerful acid-reducing medicines. They work by blocking the action of the tiny pumps within acid-secreting cells. Commonly prescribed medicines include lansoprazole (Prevacid), omeprazole (Prilosec, Zegerid), pantoprazole (Protonix), rabeprazole (Aciphex) and esomeprazole (Nexium). Talk with your care professional about the risks of taking these medicines long term.

• #7 Zollinger-Ellison syndrome | UM Health-Sparrow

  https://www.uofmhealthsparrow.org/departments-conditions/conditions/zollinger-ellison-syndrome

  Zollinger-Ellison syndrome is a condition in which one or more tumors grow in the pancreas or small intestine. The tumors, called gastrinomas, produce large amounts of the hormone gastrin. Gastrin causes the stomach to produce too much acid, which leads to peptic ulcers. High gastrin levels also can cause diarrhea, belly pain and other symptoms. […] Treatment of Zollinger-Ellison syndrome focuses on treating the hormone-secreting tumors as well as the ulcers they cause. […] Excess acid production can almost always be controlled. Medicines known as proton pump inhibitors are the first line of treatment. These are effective medicines for controlling acid production in Zollinger-Ellison syndrome. […] Proton pump inhibitors are powerful acid-reducing medicines. They work by blocking the action of the tiny „pumps” within acid-secreting cells. Commonly prescribed medicines include lansoprazole (Prevacid), omeprazole (Prilosec, Zegerid), pantoprazole (Protonix), rabeprazole (Aciphex) and esomeprazole (Nexium). Talk with your care professional about the risks of taking these medicines long term.

• #8 Zollinger-Ellison Syndrome (ZES) – Gastric Diseases – Gastrointestinal Diseases – Gastroenterology – Diseases – McMaster Textbook of Internal Medicine

  https://empendium.com/mcmtextbook/chapter/B31.II.4.70.2.

  Zollinger-Ellison syndrome (ZES) is characterized by gastrin-secreting tumors (gastrinomas), which are most frequently located in the duodenum or pancreas, rarely in adjacent lymph nodes. […] The goal of treatment is to heal peptic ulcers and remove the gastrin-secreting tumor(s), whenever possible. Medical therapy is the standard of care for most ZES patients with MEN 1 syndrome, whereas curative surgery is the standard for patients with sporadic disease and no metastatic spread. […] Medical therapy: PPIs in higher doses, for example, omeprazole 60 mg daily, esomeprazole 120 mg daily, lansoprazole 45 mg daily, rabeprazole 60 mg daily, or pantoprazole 80 mg daily. Somatostatin analogues may be used in patients with symptomatic metastatic gastrinomas, although response is variable. […] Surgical treatment: Curative tumor resection. If location of the tumor was not established using imaging tests, exploratory laparotomy with careful inspection of the abdominal cavity should be performed. Approximately 50% of patients who have had a tumor successfully removed remain in good clinical condition for many years; the others require further anticancer treatment. Successful resection reduces the risk of morbidity associated with subsequent metastatic tumor spread.

• #9 Zollinger-Ellison Syndrome Treatment & Management: Medical Care, Surgical Care

  https://emedicine.medscape.com/article/183555-treatment

  The goals of treatment in patients with Zollinger-Ellison syndrome (ZES) are medical control of gastric acid hypersecretion and surgical resection of the tumor. Inpatient care is aimed at first controlling the gastric acid hypersecretion. Once gastric acid hypersecretion is controlled, imaging studies should be obtained to localize the tumor and determine tumor extent. […] If the patient is acutely ill, immediate control of gastric acid hypersecretion can be achieved with intravenous proton pump inhibitors. […] Patients who are candidates for surgical resection should be referred for resection of the tumor. […] All patients with sporadic Zollinger-Ellison syndrome (ZES) without hepatic metastases or medical contraindications to surgery are advised to undergo surgical resection of the tumor because this decreases the risk of developing liver metastases, which can decrease the survival of these patients.

• #10 Zollinger-Ellison syndrome – Diagnosis and treatment – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/zollinger-ellison-syndrome/diagnosis-treatment/drc-20379046

  Treatment of Zollinger-Ellison syndrome focuses on treating the hormone-secreting tumors as well as the ulcers they cause. […] Excess acid production can almost always be controlled. Medicines known as proton pump inhibitors are the first line of treatment. These are effective medicines for controlling acid production in Zollinger-Ellison syndrome. […] Proton pump inhibitors are powerful acid-reducing medicines. They work by blocking the action of the tiny „pumps” within acid-secreting cells. Commonly prescribed medicines include lansoprazole (Prevacid), omeprazole (Prilosec, Zegerid), pantoprazole (Protonix), rabeprazole (Aciphex) and esomeprazole (Nexium). Talk with your care professional about the risks of taking these medicines long term. […] Octreotide (Sandostatin), a medicine similar to the hormone somatostatin, may counteract the effects of gastrin and be helpful for some people.

• #11 Zollinger Ellison Syndrome Mnemonic

  https://www.picmonic.com/pathways/medicine/courses/standard/pathology-196/neuroendocrine-disorders-39305/zollinger-ellison-syndrome-diagnosis-and-treatment_1343

  Octreotide is a somatostatin analog that is used as a second-line agent in treating Zollinger-Ellison syndrome (ZES). This medication is very effective in treating VIPomas, carcinoid tumors and glucagonomas, but has unpredictable results with the gastrinomas seen with ZES. Despite its unpredictability, this drug can reduce gastrin levels and may slow tumor growth, and can be used in patients who have unsuccessful results with high-dose proton pump inhibitors. […] Surgery is the only modality of treatment which may lead to a cure. This, however, is hinged on the tumor being in a resectable area and non-metastatic. All sporadic cases of Zollinger-Ellison syndrome (ZES) should be surgically explored (including duodenotomy) even with negative imaging results, because of the high likelihood of finding and removing a tumor for potential cure.

• #12 Zollinger-Ellison Syndrome: Not Your Average Peptic Ulcer Disease | MDedge

  https://community.the-hospitalist.org/content/zollinger-ellison-syndrome-not-your-average-peptic-ulcer-disease

  A more severe variant of peptic ulcer disease, Zollinger-Ellison syndrome (ZES) is a rare, chronic, and potentially life-threatening ulcerative disorder. […] Clinicians should suspect ZES in patients with peptic ulcer disease that is refractory to traditional medications. […] Medical management should begin immediately to prevent any further damage from prolonged gastric hypersecretion. […] Pharmacologic options include PPIs, H2-receptor antagonists, and somatostatin analogues; PPIs are considered firstline therapy. […] Once a ZES diagnosis has been made, the tumor(s) resected (if appropriate), and vagotomy considered or performed, patients will need routine follow-up with their gastroenterologist and their primary care provider, who can manage medications and recommend any lifestyle changes.

• #13 Zollinger Ellison Syndrome Mnemonic

  https://www.picmonic.com/pathways/medicine/courses/standard/pathology-196/neuroendocrine-disorders-39305/zollinger-ellison-syndrome-diagnosis-and-treatment_1343

  Octreotide is a somatostatin analog that is used as a second-line agent in treating Zollinger-Ellison syndrome (ZES). This medication is very effective in treating VIPomas, carcinoid tumors and glucagonomas, but has unpredictable results with the gastrinomas seen with ZES. Despite its unpredictability, this drug can reduce gastrin levels and may slow tumor growth, and can be used in patients who have unsuccessful results with high-dose proton pump inhibitors. […] Surgery is the only modality of treatment which may lead to a cure. This, however, is hinged on the tumor being in a resectable area and non-metastatic. All sporadic cases of Zollinger-Ellison syndrome (ZES) should be surgically explored (including duodenotomy) even with negative imaging results, because of the high likelihood of finding and removing a tumor for potential cure.

• #14 Zollinger Ellison Syndrome Mnemonic

  https://www.picmonic.com/pathways/medicine/courses/standard/pathology-196/neuroendocrine-disorders-39305/zollinger-ellison-syndrome-diagnosis-and-treatment_1343

  Octreotide is a somatostatin analog that is used as a second-line agent in treating Zollinger-Ellison syndrome (ZES). This medication is very effective in treating VIPomas, carcinoid tumors and glucagonomas, but has unpredictable results with the gastrinomas seen with ZES. Despite its unpredictability, this drug can reduce gastrin levels and may slow tumor growth, and can be used in patients who have unsuccessful results with high-dose proton pump inhibitors. […] Surgery is the only modality of treatment which may lead to a cure. This, however, is hinged on the tumor being in a resectable area and non-metastatic. All sporadic cases of Zollinger-Ellison syndrome (ZES) should be surgically explored (including duodenotomy) even with negative imaging results, because of the high likelihood of finding and removing a tumor for potential cure.

• #15 Zollinger-Ellison Syndrome – Endocrine Surgery | UCLA Health

  https://www.uclahealth.org/medical-services/surgery/endocrine-surgery/patient-resources/patient-education/endocrine-surgery-encyclopedia/zollinger-ellison-syndrome

  Zollinger-Ellison syndrome is a condition caused by abnormal production of the hormone gastrin. A small tumor (gastinoma) in the pancreas or small intestine produces the high levels of gastrin in the blood. […] Patients with Zollinger-Ellison syndrome may experience abdominal pain and diarrhea. […] A class of acid-suppressing medications called proton pump inhibitors (for example, omeprazole, lansoprazole) is now the first choice of treatment of Zollinger-Ellison syndrome. These drugs dramatically reduce acid production by the stomach, and promote healing of ulcers in the stomach and small bowel. They also provide relief of abdominal pain and diarrhea. […] Surgical removal of a single gastrinoma may be attempted if there is no evidence that it has spread to other organs (such as lymph nodes or the liver).

• #16 Zollinger-Ellison Syndrome Treatment & Management: Medical Care, Surgical Care

  https://emedicine.medscape.com/article/183555-treatment

  The goals of treatment in patients with Zollinger-Ellison syndrome (ZES) are medical control of gastric acid hypersecretion and surgical resection of the tumor. Inpatient care is aimed at first controlling the gastric acid hypersecretion. Once gastric acid hypersecretion is controlled, imaging studies should be obtained to localize the tumor and determine tumor extent. […] If the patient is acutely ill, immediate control of gastric acid hypersecretion can be achieved with intravenous proton pump inhibitors. […] Patients who are candidates for surgical resection should be referred for resection of the tumor. […] All patients with sporadic Zollinger-Ellison syndrome (ZES) without hepatic metastases or medical contraindications to surgery are advised to undergo surgical resection of the tumor because this decreases the risk of developing liver metastases, which can decrease the survival of these patients.

• #17 Zollinger-Ellison Syndrome Treatment & Management: Medical Care, Surgical Care

  https://emedicine.medscape.com/article/183555-treatment

  The goals of treatment in patients with Zollinger-Ellison syndrome (ZES) are medical control of gastric acid hypersecretion and surgical resection of the tumor. Inpatient care is aimed at first controlling the gastric acid hypersecretion. Once gastric acid hypersecretion is controlled, imaging studies should be obtained to localize the tumor and determine tumor extent. […] If the patient is acutely ill, immediate control of gastric acid hypersecretion can be achieved with intravenous proton pump inhibitors. […] Patients who are candidates for surgical resection should be referred for resection of the tumor. […] All patients with sporadic Zollinger-Ellison syndrome (ZES) without hepatic metastases or medical contraindications to surgery are advised to undergo surgical resection of the tumor because this decreases the risk of developing liver metastases, which can decrease the survival of these patients.

• #18 Zollinger-Ellison Syndrome – Endocrine Surgery | UCLA Health

  https://www.uclahealth.org/medical-services/surgery/endocrine-surgery/patient-resources/patient-education/endocrine-surgery-encyclopedia/zollinger-ellison-syndrome

  Early diagnosis and surgical removal of the tumor is associated with a cure rate of only 20% to 25%. However, gastrinomas grow slowly, and patients may live for many years after the tumor is discovered. Acid-suppressing medications are very effective at controlling the symptoms of acid overproduction. […] Call your provider if severe, persistent abdominal pain occurs, especially if it occurs with diarrhea.

• #19 Zollinger-Ellison Syndrome: Symptoms & Treatment

  https://my.clevelandclinic.org/health/diseases/17960-zollinger-ellison-syndrome

  Zollinger-Ellison syndrome may not cause symptoms. When it does, symptoms may include: […] Your treatment will depend on your symptoms and whether the gastrinomas are cancerous or noncancerous. Treatment options include medication, surgery and cancer therapy. […] Proton pump inhibitors (PPIs) are the most common medication for Zollinger-Ellison syndrome. Proton pump inhibitors reduce the amount of gastric acid your stomach produces. […] Your provider may recommend surgery to remove the tumor. Surgeries to remove gastrinoma tumors include: […] Surgery to remove cancerous gastrinomas may cure the condition. But a cure depends on removing all cancerous cells in your body. If surgery is successful, you’ll need to take medication to manage gastric acid for the rest of your life. […] Most people will always need medication to reduce gastric acid. Zollinger-Ellison syndrome happens because you have gastrinoma tumors. Most of these tumors are cancerous. If you have cancerous tumors, you’ll need follow-up care to confirm the tumors haven’t come back. […] You should contact your provider if Zollinger-Ellison symptoms get worse after treatment or come back.

• #20 Zollinger-Ellison syndrome Information | Mount Sinai – New York

  https://www.mountsinai.org/health-library/diseases-conditions/zollinger-ellison-syndrome

  Medicines called proton pump inhibitors (omeprazole, lansoprazole, and others) are used for treating this problem. These medicines reduce acid production by the stomach. This helps the ulcers in the stomach and small intestine heal. These medicines also relieve abdominal pain and diarrhea. […] Surgery to remove a single gastrinoma may be done if the tumors have not spread to other organs. Surgery on the stomach (gastrectomy) to control acid production is rarely needed.

• #21 Zollinger-Ellison Syndrome (ZES) | Loma Linda University Health

  https://lluh.org/conditions/zollinger-ellison-syndrome-zes

  Zollinger-Ellison syndrome is typically treated with medication, surgery or a combination of the two. […] At Loma Linda University, our Gastroenterology and Hepatology department provides state-of-the-art, patient-centered care for those suffering from digestive disorders such as Zollinger-Ellison syndrome. […] Medications known as proton pump inhibitors are powerful drugs that reduce acid by blocking the action of the tiny „pumps” within acid-secreting cells, and they are the first line of treatment. […] An operation to remove the tumors that occur in Zollinger-Ellison may be necessary. […] Doctors may advise other treatments to control tumor growth, including debulking, embolization or radiofrequency ablation, injecting medications, chemotherapy, enucleation, resection of the pancreas, duodenal exploration, lymph nodes removal, and liver transplant.

• #22 Zollinger-Ellison Syndrome (ZES) | Loma Linda University Health

  https://lluh.org/conditions/zollinger-ellison-syndrome-zes

  Zollinger-Ellison syndrome is typically treated with medication, surgery or a combination of the two. […] At Loma Linda University, our Gastroenterology and Hepatology department provides state-of-the-art, patient-centered care for those suffering from digestive disorders such as Zollinger-Ellison syndrome. […] Medications known as proton pump inhibitors are powerful drugs that reduce acid by blocking the action of the tiny „pumps” within acid-secreting cells, and they are the first line of treatment. […] An operation to remove the tumors that occur in Zollinger-Ellison may be necessary. […] Doctors may advise other treatments to control tumor growth, including debulking, embolization or radiofrequency ablation, injecting medications, chemotherapy, enucleation, resection of the pancreas, duodenal exploration, lymph nodes removal, and liver transplant.

• #23 Zollinger-Ellison Syndrome

  https://healthlibrary.brighamandwomens.org/wellness/smoking/tools/134,209

  Zollinger-Ellison syndrome (ZES) is a rare digestive disorder that occurs when one or more tumors called gastrinomas located in your pancreas or duodenum cause your stomach to make too much acid. […] Medicines called proton pump inhibitors can help manage the extra stomach acid. These medicines help to stop ulcers from forming. […] In some cases, you need surgery to remove tumors in your digestive tract. In the most severe cases, if the tumors are cancerous, your health care provider may give you chemotherapy. […] In most people, the ulcers can be managed if treatment suggestions are followed. […] If left untreated, there can be serious complications. […] Treatment may include medicines and sometimes surgery.

• #24 Zollinger-Ellison Syndrome Treatment & Management: Medical Care, Surgical Care

  https://emedicine.medscape.com/article/183555-treatment

  After surgical resection of a gastrinoma, patients should be assessed for evidence of recurrence with serum fasting gastrin levels, a secretin test, and SRS. The first evaluation should be performed at 3-6 months postresection and then, optimally, yearly thereafter. […] Proton pump inhibitors can be continued with the goal of maintaining the basal acid output (BAO) below 10 mEq/h before the next dose of the proton pump inhibitors.

• #25 Zollinger-Ellison Syndrome Treatment & Management: Medical Care, Surgical Care

  https://emedicine.medscape.com/article/183555-treatment

  After surgical resection of a gastrinoma, patients should be assessed for evidence of recurrence with serum fasting gastrin levels, a secretin test, and SRS. The first evaluation should be performed at 3-6 months postresection and then, optimally, yearly thereafter. […] Proton pump inhibitors can be continued with the goal of maintaining the basal acid output (BAO) below 10 mEq/h before the next dose of the proton pump inhibitors.

• #26 Zollinger-Ellison Syndrome Treatment & Management: Medical Care, Surgical Care

  https://emedicine.medscape.com/article/183555-treatment

  After surgical resection of a gastrinoma, patients should be assessed for evidence of recurrence with serum fasting gastrin levels, a secretin test, and SRS. The first evaluation should be performed at 3-6 months postresection and then, optimally, yearly thereafter. […] Proton pump inhibitors can be continued with the goal of maintaining the basal acid output (BAO) below 10 mEq/h before the next dose of the proton pump inhibitors.

• #27 Zollinger–Ellison Syndrome

  https://neuroendocrine.org.au/zollinger-ellison-syndrome/

  ZollingerEllison Syndrome (ZES) is a rare disorder characterised by the formation of gastrin-secreting tumours, known as gastrinomas, which lead to excessive production of gastric acid. […] Understanding and managing ZES is crucial for improving patient outcomes and quality of life. […] Patients diagnosed with ZollingerEllison Syndrome can engage with NECA’s comprehensive support and information by calling the NET nurse line. […] Regular medical follow-ups and monitoring are crucial to track disease progression and manage complications, such as peptic ulcers and gastrointestinal bleeding. […] Support from healthcare providers, patient education, and community resources, such as those offered by Neuroendocrine Cancer Australia (NECA), are essential in helping patients and their families cope with the physical and emotional challenges of living with ZES.

• #28 Zollinger-Ellison Syndrome

  https://healthlibrary.ecuhealth.org/Library/Wellness/Parenting/134,209

  ZES can sometimes be serious with severe complications if not treated. See your health care provider for a diagnosis if any of the symptoms last for more than a few days. Seek emergency medical care if you have any signs of intestinal bleeding, such as black or tarry stool, blood in the stool, or vomiting blood. […] Treatment may include medicines and sometimes surgery.

• #29 Zollinger-Ellison Syndrome: Not Your Average Peptic Ulcer Disease | MDedge

  https://community.the-hospitalist.org/content/zollinger-ellison-syndrome-not-your-average-peptic-ulcer-disease

  Patients need to understand that compliance is necessary to properly manage symptoms; certain foods, alcohol, and tobacco can affect the condition, and lifestyle modifications should be made, as they would with typical GERD or peptic ulcer disease. […] Proper pharmacologic management is instrumental for controlling symptoms and decreasing acid production. […] Surgical resection offers patients the best chance for a complete cure. […] Clinicians and patients should be well educated about ZES in order to successfully manage the disorder.

• #30 FloridaHealthFinder | Zollinger-Ellison syndrome | Health Encyclopedia | FloridaHealthFinder

  https://quality.healthfinder.fl.gov/health-encyclopedia/HIE/1/000325

  Zollinger-Ellison syndrome is a condition in which the body produces too much of the hormone gastrin. Most of the time, a small tumor (gastrinoma) in the pancreas or small intestine is the source of the extra gastrin in the blood. […] Drugs called proton pump inhibitors (omeprazole, lansoprazole, and others) are used for treating this problem. These drugs reduce acid production by the stomach. This helps the ulcers in the stomach and small intestine heal. These medicines also relieve abdominal pain and diarrhea. […] Surgery to remove a single gastrinoma may be done if the tumors have not spread to other organs. Surgery on the stomach (gastrectomy) to control acid production is rarely needed. […] The cure rate is low, even when it is found early and the tumor is removed. However, gastrinomas grow slowly. People with this condition may live for many years after the tumor is found. Acid-suppressing medicines work well to control the symptoms. […] Contact your health care provider if you have severe abdominal pain that does not go away, especially if it occurs with diarrhea.

• #31 Zollinger-Ellison Syndrome: Symptoms & Treatment

  https://my.clevelandclinic.org/health/diseases/17960-zollinger-ellison-syndrome

  Zollinger-Ellison syndrome may not cause symptoms. When it does, symptoms may include: […] Your treatment will depend on your symptoms and whether the gastrinomas are cancerous or noncancerous. Treatment options include medication, surgery and cancer therapy. […] Proton pump inhibitors (PPIs) are the most common medication for Zollinger-Ellison syndrome. Proton pump inhibitors reduce the amount of gastric acid your stomach produces. […] Your provider may recommend surgery to remove the tumor. Surgeries to remove gastrinoma tumors include: […] Surgery to remove cancerous gastrinomas may cure the condition. But a cure depends on removing all cancerous cells in your body. If surgery is successful, you’ll need to take medication to manage gastric acid for the rest of your life. […] Most people will always need medication to reduce gastric acid. Zollinger-Ellison syndrome happens because you have gastrinoma tumors. Most of these tumors are cancerous. If you have cancerous tumors, you’ll need follow-up care to confirm the tumors haven’t come back. […] You should contact your provider if Zollinger-Ellison symptoms get worse after treatment or come back.

• #32 Zollinger-Ellison Syndrome: Challenges and Management Strategies

  https://www.longdom.org/open-access/zollingerellison-syndrome-challenges-and-management-strategies-102334.html

  Zollinger-Ellison Syndrome (ZES) is a rare and chronic disorder characterized by the development of gastrin-secreting tumors called gastrinomas, typically found in the pancreas or duodenum. […] Managing ZES is a lifelong challenge for those affected, as it demands a comprehensive approach that encompasses medical, dietary, and sometimes surgical interventions. […] The primary goal of medical management in ZES is to suppress gastric acid production. Proton pump inhibitors (PPIs) are the cornerstone of therapy, as they effectively reduce stomach acid secretion. […] Nutritional management plays a crucial role in ZES. A dietitian’s expertise can help design a dietary plan that ensures adequate nutrient intake while minimizing exacerbation of acid hypersecretion. […] Coping with the challenges of ZES can be overwhelming, and psychological support is vital. Patients may benefit from counseling, support groups, and connecting with others facing similar experiences.

• #33 Zollinger-Ellison Syndrome: Symptoms, Causes, Diagnosis & Treatment | Medanta

  https://www.medanta.org/pillar/zollinger-ellison-syndrome-symptoms-causes-treatment-diagnosis

  Zollinger-Ellison Syndrome (ZES) is a rare medical condition that affects the pancreas, causing the formation of tumours that produce excessive amounts of gastrin. The treatment and Zollinger Ellison Syndrome management depends on the stage of the condition and the severity of the symptoms. The primary aim of treatment of Zollinger Ellison Syndrome is to curb the production of stomach acid and control the symptoms of ZES. Some of the treatment options for ZES include: […] Surgery may be recommended to remove the tumours if they are causing significant symptoms Zollinger Ellison Syndrome or have the potential to become cancerous. […] The road to recovery after treatment for ZES can vary based on the condition and the type of treatment received. After treatment, following up with your healthcare provider regularly is essential to monitor the state and ensure that it does not return. […] Lifestyle changes such as avoiding trigger foods, eating smaller meals more frequently, and managing stress can help manage symptoms of Zollinger-Ellison Syndrome in addition to medical treatment.

• #34 Zollinger-Ellison Syndrome: Challenges and Management Strategies

  https://www.longdom.org/open-access/zollingerellison-syndrome-challenges-and-management-strategies-102334.html

  Zollinger-Ellison Syndrome (ZES) is a rare and chronic disorder characterized by the development of gastrin-secreting tumors called gastrinomas, typically found in the pancreas or duodenum. […] Managing ZES is a lifelong challenge for those affected, as it demands a comprehensive approach that encompasses medical, dietary, and sometimes surgical interventions. […] The primary goal of medical management in ZES is to suppress gastric acid production. Proton pump inhibitors (PPIs) are the cornerstone of therapy, as they effectively reduce stomach acid secretion. […] Nutritional management plays a crucial role in ZES. A dietitian’s expertise can help design a dietary plan that ensures adequate nutrient intake while minimizing exacerbation of acid hypersecretion. […] Coping with the challenges of ZES can be overwhelming, and psychological support is vital. Patients may benefit from counseling, support groups, and connecting with others facing similar experiences.

• #35 Zollinger–Ellison Syndrome

  https://neuroendocrine.org.au/zollinger-ellison-syndrome/

  ZollingerEllison Syndrome (ZES) is a rare disorder characterised by the formation of gastrin-secreting tumours, known as gastrinomas, which lead to excessive production of gastric acid. […] Understanding and managing ZES is crucial for improving patient outcomes and quality of life. […] Patients diagnosed with ZollingerEllison Syndrome can engage with NECA’s comprehensive support and information by calling the NET nurse line. […] Regular medical follow-ups and monitoring are crucial to track disease progression and manage complications, such as peptic ulcers and gastrointestinal bleeding. […] Support from healthcare providers, patient education, and community resources, such as those offered by Neuroendocrine Cancer Australia (NECA), are essential in helping patients and their families cope with the physical and emotional challenges of living with ZES.

• #36 Zollinger-Ellison syndrome – Symptoms, diagnosis and treatment | BMJ Best Practice US

  https://bestpractice.bmj.com/topics/en-us/408

  Zollinger-Ellison syndrome (ZES) is a condition caused by gastrin-producing neuroendocrine tumor that causes gastric acid hypersecretion and peptic ulcer disease. […] The main goal of treatment is control of gastric hypersecretion with proton-pump inhibitors. […] Key diagnostic factors include refractory or recurrent peptic ulcer disease and diarrhea. […] Other diagnostic factors include epigastric abdominal pain, gastroesophageal reflux disease, steatorrhea, gastrointestinal bleed, and bone pain. […] 1st tests to order include fasting serum gastrin and gastric pH.

• #37 Zollinger- Ellison syndrome. | Nursing Times

  https://www.nursingtimes.net/gastroenterology/zollinger-ellison-syndrome-20-06-2006/

  – The main treatment for Zollinger-Ellison syndrome is proton pump inhibitors, which reduce the amount of acid produced in the stomach and so promote the healing of ulcers. They are also able to reduce diarrhoea. […] – Rarely, a single gastrinoma can be surgically removed if there is no evidence that it is spreading to other organs such as the lymph nodes. […] – However, the gastrinomas involved in Zollinger-Ellison syndrome can grow slowly and patients may live for many years after a tumour is diagnosed. […] – A number of complications are associated with Zollinger-Ellison syndrome, including: […] – Severe diarrhoea and weight loss may occur.

• #38 Zollinger- Ellison syndrome. | Nursing Times

  https://www.nursingtimes.net/gastroenterology/zollinger-ellison-syndrome-20-06-2006/

  – The main treatment for Zollinger-Ellison syndrome is proton pump inhibitors, which reduce the amount of acid produced in the stomach and so promote the healing of ulcers. They are also able to reduce diarrhoea. […] – Rarely, a single gastrinoma can be surgically removed if there is no evidence that it is spreading to other organs such as the lymph nodes. […] – However, the gastrinomas involved in Zollinger-Ellison syndrome can grow slowly and patients may live for many years after a tumour is diagnosed. […] – A number of complications are associated with Zollinger-Ellison syndrome, including: […] – Severe diarrhoea and weight loss may occur.

• #39 Zollinger-Ellison syndrome | Beacon Health System

  https://www.beaconhealthsystem.org/library/diseases-and-conditions/zollinger-ellison-syndrome?content_id=CON-20379029

  Zollinger-Ellison syndrome is a condition in which one or more tumors grow in the pancreas or small intestine. The tumors, called gastrinomas, produce large amounts of the hormone gastrin. Gastrin causes the stomach to produce too much acid, which leads to peptic ulcers. High gastrin levels also can cause diarrhea, belly pain and other symptoms. […] Treatment of Zollinger-Ellison syndrome focuses on treating the hormone-secreting tumors as well as the ulcers they cause. […] Excess acid production can almost always be controlled. Medicines known as proton pump inhibitors are the first line of treatment. These are effective medicines for controlling acid production in Zollinger-Ellison syndrome. […] Your symptoms may prompt you to visit your primary healthcare professional first. Your care professional will likely refer you to a doctor who specializes in diseases of the digestive system, called a gastroenterologist. You also may be referred to an oncologist. An oncologist is a doctor who specializes in treating cancer.

• #40 Zollinger-Ellison syndrome | UM Health-Sparrow

  https://www.uofmhealthsparrow.org/departments-conditions/conditions/zollinger-ellison-syndrome

  Your symptoms may prompt you to visit your primary healthcare professional first. Your care professional will likely refer you to a doctor who specializes in diseases of the digestive system, called a gastroenterologist. You also may be referred to an oncologist. An oncologist is a doctor who specializes in treating cancer.

• #41 Zollinger–Ellison Syndrome

  https://neuroendocrine.org.au/zollinger-ellison-syndrome/

  ZollingerEllison Syndrome (ZES) is a rare disorder characterised by the formation of gastrin-secreting tumours, known as gastrinomas, which lead to excessive production of gastric acid. […] Understanding and managing ZES is crucial for improving patient outcomes and quality of life. […] Patients diagnosed with ZollingerEllison Syndrome can engage with NECA’s comprehensive support and information by calling the NET nurse line. […] Regular medical follow-ups and monitoring are crucial to track disease progression and manage complications, such as peptic ulcers and gastrointestinal bleeding. […] Support from healthcare providers, patient education, and community resources, such as those offered by Neuroendocrine Cancer Australia (NECA), are essential in helping patients and their families cope with the physical and emotional challenges of living with ZES.

• #42 Zollinger-Ellison syndrome | Beacon Health System

  https://www.beaconhealthsystem.org/library/diseases-and-conditions/zollinger-ellison-syndrome?content_id=CON-20379029

  Be aware of any pre-appointment restrictions. When you make the appointment, let your care team know if you take any medicines. Certain acid-reducing medicines, such as proton pump inhibitors or H-2 blockers, can affect the results of some tests used to diagnose Zollinger-Ellison syndrome. However, don’t stop taking these medicines without asking your care professional first.

• #43 Zollinger-Ellison syndrome // Middlesex Health

  https://middlesexhealth.org/learning-center/diseases-and-conditions/zollinger-ellison-syndrome

  Be aware of any pre-appointment restrictions. When you make the appointment, let your care team know if you take any medicines. Certain acid-reducing medicines, such as proton pump inhibitors or H-2 blockers, can affect the results of some tests used to diagnose Zollinger-Ellison syndrome. […] For Zollinger-Ellison syndrome, some basic questions to ask include: What treatments are available for Zollinger-Ellison syndrome, and which do you recommend for me? […] You’ll likely be asked a few questions during the appointment, including: Have you ever been told you have a stomach ulcer? How was it diagnosed?

• #44 Zollinger–Ellison Syndrome

  https://neuroendocrine.org.au/zollinger-ellison-syndrome/

  Patients with ZES can benefit from dietary and lifestyle changes to manage symptoms and improve overall health. […] Ongoing monitoring is essential for managing ZES and preventing complications. […] Supportive care is crucial for improving the quality of life for patients with ZES. […] Neuroendocrine Cancer Australia (NECA) provides comprehensive support for patients living with ZollingerEllison Syndrome (ZES) and their families. […] ZollingerEllison Syndrome is a complex condition that requires a multidisciplinary approach for effective management. […] Early diagnosis, appropriate medical and surgical treatments, and ongoing supportive care are essential to improving patient outcomes.

• #45 Zollinger-Ellison Syndrome: Not Your Average Peptic Ulcer Disease | MDedge

  https://community.the-hospitalist.org/content/zollinger-ellison-syndrome-not-your-average-peptic-ulcer-disease

  Patients need to understand that compliance is necessary to properly manage symptoms; certain foods, alcohol, and tobacco can affect the condition, and lifestyle modifications should be made, as they would with typical GERD or peptic ulcer disease. […] Proper pharmacologic management is instrumental for controlling symptoms and decreasing acid production. […] Surgical resection offers patients the best chance for a complete cure. […] Clinicians and patients should be well educated about ZES in order to successfully manage the disorder.

• #46 Zollinger-Ellison syndrome: MedlinePlus Medical EncyclopediaLock

  https://medlineplus.gov/ency/article/000325.htm

  Zollinger-Ellison syndrome is a condition in which the body produces too much of the hormone gastrin. Most of the time, a small tumor (gastrinoma) in the pancreas or small intestine is the source of the extra gastrin in the blood. […] Medicines called proton pump inhibitors (omeprazole, lansoprazole, and others) are used for treating this problem. These medicines reduce acid production by the stomach. This helps the ulcers in the stomach and small intestine heal. These medicines also relieve abdominal pain and diarrhea. […] Surgery to remove a single gastrinoma may be done if the tumors have not spread to other organs. Surgery on the stomach (gastrectomy) to control acid production is rarely needed. […] Contact your health care provider if you have severe abdominal pain that does not go away, especially if it occurs with diarrhea.

• #47 Zollinger-Ellison Syndrome: Symptoms, Treatment, and More

  https://www.healthline.com/health/zollinger-ellison-syndrome

  Your doctor may recommend a variety of treatments. […] Your doctor may prescribe drugs called proton pump inhibitors. These can be used to help reduce the amount of gastric acid thats produced. That, in turn, can help the ulcers heal. […] In some cases, you may need surgery to remove the tumors. Surgery can be difficult because many gastrinomas are small, hard to locate, and present in multiples. Your doctor will discuss the specifics of your surgery if they decide youre a candidate for this type of treatment. […] Your doctor may also recommend treatments such as chemotherapy to shrink the tumors or radiofrequency ablation to kill off cells and stop growth of the tumors. […] See your healthcare provider if you have digestive issues like diarrhea, heartburn, or abdominal pain lasting more than a few days. Early diagnosis and treatment can help stop the spread of any cancerous tumors.

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