Zaburzenia stawu skroniowo-żuchwowego
Rokowania, prognozy i postęp choroby
Zaburzenia stawu skroniowo-żuchwowego (TMD) stanowią złożony problem kliniczny, gdzie kluczową rolę odgrywa identyfikacja czynników prognostycznych dla optymalizacji leczenia. Istotne predyktory skuteczności terapii manualnej obejmują ból podczas otwierania ust o intensywności >2/10 w skali VAS, pozytywne oczekiwania pacjenta, lokalizację bólu w regionie czaszkowo-szyjnym oraz niski wynik w skali Central Sensitisation Inventory (CSI). Redukcja bólu o ≥30% w skali VAS uznawana jest za klinicznie istotną. W diagnostyce artralgi stawu skroniowo-żuchwowego model prognostyczny oparty na MRI (przemieszczenie krążka bez redukcji, obrzęk szpiku kostnego) wykazuje wysoką skuteczność (AUC=0,916) w przewidywaniu erozji wyrostków kłykciowych (61,3% pacjentów). W leczeniu TMJ OA nowoczesne modele uczenia maszynowego, takie jak EHPN, osiągają wskaźnik F1=0,82, co umożliwia precyzyjne prognozowanie progresji choroby i wspiera decyzje terapeutyczne.
- Prognostyka zaburzeń stawu skroniowo-żuchwowego
- Czynniki prognostyczne w leczeniu odwracalnym
- Model predykcyjny dla erozji wyrostków kłykciowych
- Zaawansowane modele predykcyjne w TMD
- Potencjalne czynniki predykcyjne TMD
- Przewidywanie wyników leczenia na podstawie objawów przedterapeutycznych
- Rokowanie w zaburzeniach stawu skroniowo-żuchwowego
- Walidacja modeli prognostycznych i ich znaczenie kliniczne
- Wskaźniki prognostyczne w ocenie wyników leczenia
Prognostyka zaburzeń stawu skroniowo-żuchwowego
Zaburzenia stawu skroniowo-żuchwowego (TMD – temporomandibular disorders) to złożone, wieloczynnikowe zaburzenia, których leczenie i rokowanie stanowią istotne wyzwanie kliniczne. Prognostyka TMD jest kluczowym elementem planowania leczenia i przewidywania jego efektów, co ma znaczący wpływ na podejmowane decyzje terapeutyczne oraz jakość życia pacjentów.12
Czynniki prognostyczne w leczeniu odwracalnym
Identyfikacja czynników prognostycznych związanych z wynikami klinicznymi leczenia odwracalnego u pacjentów z TMD ma zasadnicze znaczenie dla optymalizacji terapii. Badania prospektywne wskazują na kilka istotnych czynników, które mogą przewidywać skuteczność interwencji terapeutycznych.3
Do głównych czynników prognostycznych zidentyfikowanych w badaniach należą:4
- Nasilenie bólu podczas otwierania ust – pacjenci zgłaszający ból o intensywności większej niż 2 w skali 10-punktowej podczas otwierania ust często wykazują lepszą odpowiedź na terapię manualną
- Pozytywne oczekiwania wobec wyników leczenia – pacjenci z optymistycznym nastawieniem do terapii osiągają lepsze rezultaty
- Lokalizacja bólu w regionie czaszkowo-szyjnym
- Niski wynik w skali Central Sensitisation Inventory (CSI) – wskazujący na mniejsze nasilenie centralnej sensytyzacji
Powyższe czynniki okazały się predyktorami znacznego zmniejszenia bólu po zastosowaniu programu terapii manualnej ukierunkowanej na struktury skroniowo-żuchwowe. Za klinicznie istotną uznaje się redukcję natężenia bólu o co najmniej 30% w skali VAS (Visual Analogue Scale).7
Model predykcyjny dla erozji wyrostków kłykciowych
W badaniach nad artralgią stawu skroniowo-żuchwowego opracowano model prognostyczny do przewidywania ryzyka erozji wyrostków kłykciowych (CE – Condylar Erosion). Model ten, stworzony przy użyciu analizy regresji wieloczynnikowej, wykazał wysoką skuteczność, klasyfikując poprawnie 83,9% uczestników, z polem pod krzywą ROC (AUC) wynoszącym 0,916.8
Najważniejsze wskaźniki prognostyczne w tym modelu to:9
- Obecność przemieszczenia krążka bez redukcji w badaniu MRI
- Występowanie obrzęku szpiku kostnego w badaniu MRI
Wyniki badań obrazowych MRI wykazały, że pacjenci z artralgią stawu skroniowo-żuchwowego charakteryzują się wysokim odsetkiem erozji wyrostków kłykciowych (61,3%). Model predykcyjny może służyć jako metoda przewidywania ryzyka erozji wyrostków kłykciowych, dostarczając cennych informacji dla dalszego postępowania klinicznego i planowania leczenia.11
Zaawansowane modele predykcyjne w TMD
Najnowsze badania wprowadzają bardziej zaawansowane modele prognostyczne, wykorzystujące metody uczenia maszynowego. Jednym z takich narzędzi jest model EHPN (Ensemble via Hierarchical Predictions through Nested cross-validation), który został opracowany specjalnie do przewidywania progresji choroby zwyrodnieniowej stawu skroniowo-żuchwowego (TMJ OA).12
Model EHPN osiągnął wskaźnik F1 na poziomie 0,82, co świadczy o jego wysokiej skuteczności i niezawodności w analizie nowych, niewidzianych wcześniej danych, przy jednoczesnym minimalizowaniu wyników fałszywie dodatnich i ujemnych. Zastosowanie tego modelu może zrewolucjonizować standardy opieki, zapewniając klinicystom dokładne narzędzie do przewidywania przyszłego stanu pacjentów z TMJ OA, tym samym usprawniając proces podejmowania decyzji terapeutycznych.13
Potencjalne czynniki predykcyjne TMD
W badaniach nad czynnikami ryzyka rozwoju zaburzeń stawu skroniowo-żuchwowego zidentyfikowano kilka potencjalnych predyktorów:14
- Parafunkcje (np. zgrzytanie zębami, zaciskanie szczęk)
- Starcie zębów wynikające z przewlekłego bruksizmu
- Trzaski w stawie skroniowo-żuchwowym
- Głęboki nagryz
Należy jednak zaznaczyć, że wartość predykcyjna tych czynników wymaga dalszych badań, szczególnie w kontekście długoterminowej prognozy. Badacze podkreślają, że na podstawie obecnych danych nie można jednoznacznie stwierdzić, czy czynniki wykryte w dzieciństwie mogą przewidywać jawne (świadomość pacjenta) zaburzenia stawu skroniowo-żuchwowego w przyszłości.16
Przewidywanie wyników leczenia na podstawie objawów przedterapeutycznych
W kontekście przewidywania wyników standardowego programu leczenia TMD, badania wskazują, że wysoki stopień zaburzeń funkcji żuchwy przed leczeniem może negatywnie wpływać na rokowanie. W szczególności, jeśli obecne są objawy takie jak trzaski czy blokowanie stawu, prognoza poprawy po zastosowaniu krótkotrwałej, samodzielnej fizykoterapii, szyny okluzyjnej i niesteroidowych leków przeciwzapalnych (NLPZ) może być gorsza, przynajmniej w krótkim okresie obserwacji.17
Rokowanie w zaburzeniach stawu skroniowo-żuchwowego
Zaburzenia stawu skroniowo-żuchwowego mogą mieć różny przebieg i rokowanie. W niektórych przypadkach TMD ustępuje samoistnie w ciągu jednego do dwóch tygodni, jednak w cięższych przypadkach może trwać kilka miesięcy lub nawet lat. Zaburzenia TMD mogą mieć charakter krótkotrwały (ostry) lub długotrwały (przewlekły).18
Istotne jest, że przy odpowiednim leczeniu i postępowaniu możliwe jest wyleczenie dysfunkcji stawu skroniowo-żuchwowego. Efekty terapii są jednak zróżnicowane – u niektórych pacjentów jest to tymczasowy problem, który szybko ustępuje, podczas gdy u innych może stać się przewlekłym schorzeniem istotnie wpływającym na jakość życia.19
Walidacja modeli prognostycznych i ich znaczenie kliniczne
Badacze podkreślają, że przed włączeniem jakiegokolwiek modelu prognostycznego do praktyki klinicznej konieczna jest jego zewnętrzna walidacja. Dopiero po pozytywnej weryfikacji w nowych kohortach pacjentów, narzędzia predykcyjne mogą być z ufnością stosowane w codziennej praktyce klinicznej.2021
Skutecznie zwalidowane narzędzia predykcyjne mogą przynieść następujące korzyści:22
- Ułatwienie podejmowania decyzji klinicznych przez terapeutów manualnych leczących pacjentów z TMD
- Poprawa wyników leczenia pacjentów
- Potencjalne zmniejszenie kosztów związanych z opieką zdrowotną
- Bardziej precyzyjny dobór odpowiednich metod terapeutycznych dla konkretnych pacjentów
Informacje prognostyczne są kluczowe przy przewidywaniu wpływu interwencji odwracalnych w populacji z TMD. Wyniki badań nad modelami prognostycznymi mogą dostarczyć nowych spostrzeżeń na temat tego, kto prawdopodobnie skorzysta z leczenia odwracalnego, a u kogo istnieje ryzyko rozwoju przewlekłego TMD. Dlatego ocena rokowania będzie cenna dla planowania leczenia pacjentów z zaburzeniami stawu skroniowo-żuchwowego.25
Wskaźniki prognostyczne w ocenie wyników leczenia
W badaniach dotyczących prognostyki TMD stosuje się różne wskaźniki do oceny wyników leczenia:26
- Zmiany w maksymalnym otwarciu przednim (anterior maximal opening) – mierzone jako zwiększenie zakresu ruchu żuchwy
- Nasilenie bólu TMD oceniane za pomocą wizualnej skali analogowej (VAS)
- Zmiany w charakterystyce bólu – jego lokalizacja, częstotliwość, intensywność
Za klinicznie istotną poprawę uznaje się zmniejszenie natężenia bólu o co najmniej 30% w skali VAS, zgodnie z zaleceniami Initiative on Methods, Measurement and Pain Assessment in Clinical Trials dotyczącymi zaburzeń stawu skroniowo-żuchwowego.28
Kompleksowa ocena prognostyczna powinna uwzględniać zarówno fizyczne, jak i psychologiczne aspekty zaburzeń stawu skroniowo-żuchwowego, aby zapewnić holistyczne podejście do przewidywania wyników leczenia i planowania odpowiednich interwencji terapeutycznych.29
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Materiały źródłowe
- #1 Prognostic factor analysis in patients with temporomandibular disorders after reversible treatment: study protocol for a prospective cohort study in Chinahttps://pmc.ncbi.nlm.nih.gov/articles/PMC8256761/
These findings suggest that prognostic information is critical when predicting the impact of reversible interventions in a population with TMD. […] The results of this study will provide new insights into who is likely to benefit from reversible treatment versus who is likely to develop chronic TMD. […] Therefore, the evaluation of prognoses will be valuable for treatment planning for patients with TMD. […] The candidate prognostic factors have been selected based on current knowledge of risk factors for developing first-onset TMD and their possible utilisation in clinical practice. […] This study will be conducted in accordance with the SPIRIT statement and PROGRESS framework.
- #2 A logistic analysis prediction model of TMJ condylar erosion in patients with TMJ arthralgia | BMC Oral Health | Full Texthttps://bmcoralhealth.biomedcentral.com/articles/10.1186/s12903-021-01687-w
Prognostic prediction models guide physicians upon therapeutic management and have become a standard to aid clinical decision-making. […] With regard to the prognostic prediction model developed in the present study, it is therefore advised that external validation is performed in ongoing studies before considering to incorporate this model into clinical practice.
- #3 Prognostic factor analysis in patients with temporomandibular disorders after reversible treatment: study protocol for a prospective cohort study in Chinahttps://pmc.ncbi.nlm.nih.gov/articles/PMC8256761/
Temporomandibular disorders (TMDs) are complex multifactorial disorders. […] However, there is a paucity of research that aims to identify prognostic factors associated with the clinical outcomes of reversible treatment in people with TMD. […] The objective of this prospective cohort study is to identify prognostic factors that are associated with clinical outcomes of reversible treatment in patients with TMD and to analyse the risk factors that influence the development of chronic TMD. […] The aims of this prospective cohort study are: (1) to identify prognostic factors that are associated with clinical outcomes of reversible treatment in patients with TMD; and (2) to analyse risk factors that influence the development of chronic TMD during a 1-year follow-up period. […] The primary treatment outcome measures will be changes in the anterior maximal opening, worsening of TMD pain assessed using the VAS and changes in pain characteristics.
- #4 External validation of a clinical prediction tool for the use of manual therapy for patients with temporomandibular disorders: a protocol for a prospective observational studyhttps://pmc.ncbi.nlm.nih.gov/articles/PMC10351239/
Clinical guidelines recommend conservative treatment for the management of temporomandibular disorders (TMD), and manual therapy directed to temporomandibular structures is commonly applied to reduce pain and improve function. […] In a recent prospective study, we developed a clinical prediction tool based on an array of predictors to identify people with TMD who are likely to experience significant pain relief and functional improvements following a programme of manual therapies (MTP) applied to temporomandibular structures. […] A reduction of pain intensity by at least 30% will be considered a good outcome. […] Our results showed that participants reporting pain intensity greater than 2 out of 10 during mouth opening, positive expectations of outcome following MT, pain localised in the craniocervical region and a low Central Sensitisation Inventory (CSI) score had significant pain reduction after four sessions of the MTP targeted to temporomandibular structures.
- #5 External validation of a clinical prediction tool for the use of manual therapy for patients with temporomandibular disorders: a protocol for a prospective observational studyhttps://pmc.ncbi.nlm.nih.gov/articles/PMC10351239/
Clinical guidelines recommend conservative treatment for the management of temporomandibular disorders (TMD), and manual therapy directed to temporomandibular structures is commonly applied to reduce pain and improve function. […] In a recent prospective study, we developed a clinical prediction tool based on an array of predictors to identify people with TMD who are likely to experience significant pain relief and functional improvements following a programme of manual therapies (MTP) applied to temporomandibular structures. […] A reduction of pain intensity by at least 30% will be considered a good outcome. […] Our results showed that participants reporting pain intensity greater than 2 out of 10 during mouth opening, positive expectations of outcome following MT, pain localised in the craniocervical region and a low Central Sensitisation Inventory (CSI) score had significant pain reduction after four sessions of the MTP targeted to temporomandibular structures.
- #6 External validation of a clinical prediction tool for the use of manual therapy for patients with temporomandibular disorders: a protocol for a prospective observational studyhttps://pmc.ncbi.nlm.nih.gov/articles/PMC10351239/
The purpose of this study is to externally validate the prediction model in a new cohort (temporal validation) of patients with TMD. […] If the performance of the clinical prediction tool in a new sample will be satisfactory, the knowledge gained from this validation study will facilitate clinical decision-making for manual therapists managing people with TMD, which will ultimately enhance patient outcomes. […] Pain intensity will be the primary outcome since patients with TMD commonly identify pain as their main problem. […] According to the Initiative on Methods, Measurement and Pain Assessment in Clinical Trials recommendations about TMD, a pain VAS score reduction of at least 30% is clinically significant. […] Pain intensity during MMO, positive expectations, pain localised to the craniocervical region and a low CSI score predicted significant pain reduction following the MTP.
- #7 External validation of a clinical prediction tool for the use of manual therapy for patients with temporomandibular disorders: a protocol for a prospective observational studyhttps://pmc.ncbi.nlm.nih.gov/articles/PMC10351239/
The purpose of this study is to externally validate the prediction model in a new cohort (temporal validation) of patients with TMD. […] If the performance of the clinical prediction tool in a new sample will be satisfactory, the knowledge gained from this validation study will facilitate clinical decision-making for manual therapists managing people with TMD, which will ultimately enhance patient outcomes. […] Pain intensity will be the primary outcome since patients with TMD commonly identify pain as their main problem. […] According to the Initiative on Methods, Measurement and Pain Assessment in Clinical Trials recommendations about TMD, a pain VAS score reduction of at least 30% is clinically significant. […] Pain intensity during MMO, positive expectations, pain localised to the craniocervical region and a low CSI score predicted significant pain reduction following the MTP.
- #8 A logistic analysis prediction model of TMJ condylar erosion in patients with TMJ arthralgia | BMC Oral Health | Full Texthttps://bmcoralhealth.biomedcentral.com/articles/10.1186/s12903-021-01687-w
The established prediction model using the risk factors of TMJ arthralgia may be useful for predicting the risk of CE. The data suggest MRI indicators as dominant factors in the definition of CE. Further research is needed to improve the model, and confirm the validity and reliability of the model. […] The results of MRI in the present study showed TMJ arthralgia patients to be associated with a high rate of CE (61.3%). […] In classifying 83.9% of participants, with an AUC of 0.916, the prediction model developed by multivariate regression analysis was efficient. […] The presence of MRI findings of disk displacement without reduction and bone marrow edema may be considered a dominant factor in the definition of CE of the TMJ. […] The predictive model can be used as a risk prediction method for CE, and thereby provide valuable information for further clinical follow-up and treatment approaches.
- #9 A logistic analysis prediction model of TMJ condylar erosion in patients with TMJ arthralgia | BMC Oral Health | Full Texthttps://bmcoralhealth.biomedcentral.com/articles/10.1186/s12903-021-01687-w
The established prediction model using the risk factors of TMJ arthralgia may be useful for predicting the risk of CE. The data suggest MRI indicators as dominant factors in the definition of CE. Further research is needed to improve the model, and confirm the validity and reliability of the model. […] The results of MRI in the present study showed TMJ arthralgia patients to be associated with a high rate of CE (61.3%). […] In classifying 83.9% of participants, with an AUC of 0.916, the prediction model developed by multivariate regression analysis was efficient. […] The presence of MRI findings of disk displacement without reduction and bone marrow edema may be considered a dominant factor in the definition of CE of the TMJ. […] The predictive model can be used as a risk prediction method for CE, and thereby provide valuable information for further clinical follow-up and treatment approaches.
- #10 A logistic analysis prediction model of TMJ condylar erosion in patients with TMJ arthralgia | BMC Oral Health | Full Texthttps://bmcoralhealth.biomedcentral.com/articles/10.1186/s12903-021-01687-w
The established prediction model using the risk factors of TMJ arthralgia may be useful for predicting the risk of CE. The data suggest MRI indicators as dominant factors in the definition of CE. Further research is needed to improve the model, and confirm the validity and reliability of the model. […] The results of MRI in the present study showed TMJ arthralgia patients to be associated with a high rate of CE (61.3%). […] In classifying 83.9% of participants, with an AUC of 0.916, the prediction model developed by multivariate regression analysis was efficient. […] The presence of MRI findings of disk displacement without reduction and bone marrow edema may be considered a dominant factor in the definition of CE of the TMJ. […] The predictive model can be used as a risk prediction method for CE, and thereby provide valuable information for further clinical follow-up and treatment approaches.
- #11 A logistic analysis prediction model of TMJ condylar erosion in patients with TMJ arthralgia | BMC Oral Health | Full Texthttps://bmcoralhealth.biomedcentral.com/articles/10.1186/s12903-021-01687-w
The established prediction model using the risk factors of TMJ arthralgia may be useful for predicting the risk of CE. The data suggest MRI indicators as dominant factors in the definition of CE. Further research is needed to improve the model, and confirm the validity and reliability of the model. […] The results of MRI in the present study showed TMJ arthralgia patients to be associated with a high rate of CE (61.3%). […] In classifying 83.9% of participants, with an AUC of 0.916, the prediction model developed by multivariate regression analysis was efficient. […] The presence of MRI findings of disk displacement without reduction and bone marrow edema may be considered a dominant factor in the definition of CE of the TMJ. […] The predictive model can be used as a risk prediction method for CE, and thereby provide valuable information for further clinical follow-up and treatment approaches.
- #12 Comprehensive model for temporomandibular joint osteoarthritis progressionhttps://www.pacific.edu/pacific-newsroom/comprehensive-patient-specific-prediction-model-temporomandibular-joint
Temporomandibular joint osteoarthritis (TMJ OA) is a common condition causing jaw pain and difficulty moving the jaw. […] The study aimed to improve prediction of how TMJ OA progresses and how patients respond to treatment. […] Researchers developed an open-source tool based on a robust method called Ensemble via Hierarchical Predictions through Nested cross-validation (EHPN), which surpassed the performance of the 48 models tested. The EHPN model achieved an F1 score of 0.82, indicating strong performance and reliability with new, unseen data, and minimizing false positives and negatives. […] The use of the EHPN model may revolutionize the standards of care, providing clinicians with an accurate tool for anticipating the future status of TMJ OA patients, thereby enhancing their decision-making process.
- #13 Comprehensive model for temporomandibular joint osteoarthritis progressionhttps://www.pacific.edu/pacific-newsroom/comprehensive-patient-specific-prediction-model-temporomandibular-joint
Temporomandibular joint osteoarthritis (TMJ OA) is a common condition causing jaw pain and difficulty moving the jaw. […] The study aimed to improve prediction of how TMJ OA progresses and how patients respond to treatment. […] Researchers developed an open-source tool based on a robust method called Ensemble via Hierarchical Predictions through Nested cross-validation (EHPN), which surpassed the performance of the 48 models tested. The EHPN model achieved an F1 score of 0.82, indicating strong performance and reliability with new, unseen data, and minimizing false positives and negatives. […] The use of the EHPN model may revolutionize the standards of care, providing clinicians with an accurate tool for anticipating the future status of TMJ OA patients, thereby enhancing their decision-making process.
- #14 Possible predictors of temporomandibular disorders | Evidence-Based Dentistryhttps://www.nature.com/articles/6400213
Some signs and symptoms appear to be predictors of TMD. More research is needed, however, to determine if any of these parameters can be used to predict TMD in the long-term. […] Parafunction, tooth wear, TMJ clicking and deep overbite are possible predictors of TMD but their predictive value still requires further study. […] This study has identified some possible predictive factors that may be established by careful history and examination, but further studies are needed to establish their predictive value. The authors further emphasise that it is not possible to draw conclusions about whether such factors detected in childhood (parafunction, tooth wear, TMJ clicking and deep overbite) can predict manifest (patient awareness of) TMD.
- #15 Possible predictors of temporomandibular disorders | Evidence-Based Dentistryhttps://www.nature.com/articles/6400213
Some signs and symptoms appear to be predictors of TMD. More research is needed, however, to determine if any of these parameters can be used to predict TMD in the long-term. […] Parafunction, tooth wear, TMJ clicking and deep overbite are possible predictors of TMD but their predictive value still requires further study. […] This study has identified some possible predictive factors that may be established by careful history and examination, but further studies are needed to establish their predictive value. The authors further emphasise that it is not possible to draw conclusions about whether such factors detected in childhood (parafunction, tooth wear, TMJ clicking and deep overbite) can predict manifest (patient awareness of) TMD.
- #16 Possible predictors of temporomandibular disorders | Evidence-Based Dentistryhttps://www.nature.com/articles/6400213
Some signs and symptoms appear to be predictors of TMD. More research is needed, however, to determine if any of these parameters can be used to predict TMD in the long-term. […] Parafunction, tooth wear, TMJ clicking and deep overbite are possible predictors of TMD but their predictive value still requires further study. […] This study has identified some possible predictive factors that may be established by careful history and examination, but further studies are needed to establish their predictive value. The authors further emphasise that it is not possible to draw conclusions about whether such factors detected in childhood (parafunction, tooth wear, TMJ clicking and deep overbite) can predict manifest (patient awareness of) TMD.
- #17https://www.jofph.com/articles/10.11607/ofph.23.3.08
Aims: To investigate whether any of the pretreatment physical signs, symptoms, and responses on psychological questionnaires would predict treatment outcomes after a standardized temporomandibular disorder (TMD) treatment program. […] The corollary of these results suggests that if a high degree of jaw function interference is present (eg, clicking, locking), then the prognosis of improvement with brief self-directed physical therapy, an occlusal appliance, and OTC NSAID is lower, at least within the time frame of this study.
- #18 TMJ Disorders: Symptoms, Causes & Treatmenthttps://my.clevelandclinic.org/health/diseases/15066-temporomandibular-disorders-tmd-overview
TMJ dysfunction affects everyone differently. For some, its a temporary issue that goes away in a week or two. For others, its a chronic condition that negatively impacts quality of life. […] It depends. In some cases, TMD goes away on its own in one to two weeks. But in severe instances, it can last several months or even years. TMJ disorder can be short term (acute) or long term (chronic). […] Yes, its possible to cure TMJ dysfunction with appropriate treatment and management.
- #19 TMJ Disorders: Symptoms, Causes & Treatmenthttps://my.clevelandclinic.org/health/diseases/15066-temporomandibular-disorders-tmd-overview
TMJ dysfunction affects everyone differently. For some, its a temporary issue that goes away in a week or two. For others, its a chronic condition that negatively impacts quality of life. […] It depends. In some cases, TMD goes away on its own in one to two weeks. But in severe instances, it can last several months or even years. TMJ disorder can be short term (acute) or long term (chronic). […] Yes, its possible to cure TMJ dysfunction with appropriate treatment and management.
- #20 External validation of a clinical prediction tool for the use of manual therapy for patients with temporomandibular disorders: a protocol for a prospective observational studyhttps://pmc.ncbi.nlm.nih.gov/articles/PMC10351239/
However, it is only after an external validation that a clinical prediction tool can be included in clinical practice with confidence. […] If the clinical prediction tool is deemed valid (i.e., predicts response to treatment), it will facilitate manual therapists treating patients with TMD, ultimately contributing to improving patient outcomes and likely, health-related costs.
- #21 A logistic analysis prediction model of TMJ condylar erosion in patients with TMJ arthralgia | BMC Oral Health | Full Texthttps://bmcoralhealth.biomedcentral.com/articles/10.1186/s12903-021-01687-w
Prognostic prediction models guide physicians upon therapeutic management and have become a standard to aid clinical decision-making. […] With regard to the prognostic prediction model developed in the present study, it is therefore advised that external validation is performed in ongoing studies before considering to incorporate this model into clinical practice.
- #22 External validation of a clinical prediction tool for the use of manual therapy for patients with temporomandibular disorders: a protocol for a prospective observational studyhttps://pmc.ncbi.nlm.nih.gov/articles/PMC10351239/
However, it is only after an external validation that a clinical prediction tool can be included in clinical practice with confidence. […] If the clinical prediction tool is deemed valid (i.e., predicts response to treatment), it will facilitate manual therapists treating patients with TMD, ultimately contributing to improving patient outcomes and likely, health-related costs.
- #23 External validation of a clinical prediction tool for the use of manual therapy for patients with temporomandibular disorders: a protocol for a prospective observational studyhttps://pmc.ncbi.nlm.nih.gov/articles/PMC10351239/
However, it is only after an external validation that a clinical prediction tool can be included in clinical practice with confidence. […] If the clinical prediction tool is deemed valid (i.e., predicts response to treatment), it will facilitate manual therapists treating patients with TMD, ultimately contributing to improving patient outcomes and likely, health-related costs.
- #24 Prognostic factor analysis in patients with temporomandibular disorders after reversible treatment: study protocol for a prospective cohort study in Chinahttps://pmc.ncbi.nlm.nih.gov/articles/PMC8256761/
These findings suggest that prognostic information is critical when predicting the impact of reversible interventions in a population with TMD. […] The results of this study will provide new insights into who is likely to benefit from reversible treatment versus who is likely to develop chronic TMD. […] Therefore, the evaluation of prognoses will be valuable for treatment planning for patients with TMD. […] The candidate prognostic factors have been selected based on current knowledge of risk factors for developing first-onset TMD and their possible utilisation in clinical practice. […] This study will be conducted in accordance with the SPIRIT statement and PROGRESS framework.
- #25 Prognostic factor analysis in patients with temporomandibular disorders after reversible treatment: study protocol for a prospective cohort study in Chinahttps://pmc.ncbi.nlm.nih.gov/articles/PMC8256761/
These findings suggest that prognostic information is critical when predicting the impact of reversible interventions in a population with TMD. […] The results of this study will provide new insights into who is likely to benefit from reversible treatment versus who is likely to develop chronic TMD. […] Therefore, the evaluation of prognoses will be valuable for treatment planning for patients with TMD. […] The candidate prognostic factors have been selected based on current knowledge of risk factors for developing first-onset TMD and their possible utilisation in clinical practice. […] This study will be conducted in accordance with the SPIRIT statement and PROGRESS framework.
- #26 Prognostic factor analysis in patients with temporomandibular disorders after reversible treatment: study protocol for a prospective cohort study in Chinahttps://pmc.ncbi.nlm.nih.gov/articles/PMC8256761/
Temporomandibular disorders (TMDs) are complex multifactorial disorders. […] However, there is a paucity of research that aims to identify prognostic factors associated with the clinical outcomes of reversible treatment in people with TMD. […] The objective of this prospective cohort study is to identify prognostic factors that are associated with clinical outcomes of reversible treatment in patients with TMD and to analyse the risk factors that influence the development of chronic TMD. […] The aims of this prospective cohort study are: (1) to identify prognostic factors that are associated with clinical outcomes of reversible treatment in patients with TMD; and (2) to analyse risk factors that influence the development of chronic TMD during a 1-year follow-up period. […] The primary treatment outcome measures will be changes in the anterior maximal opening, worsening of TMD pain assessed using the VAS and changes in pain characteristics.
- #27 Prognostic factor analysis in patients with temporomandibular disorders after reversible treatment: study protocol for a prospective cohort study in Chinahttps://pmc.ncbi.nlm.nih.gov/articles/PMC8256761/
Temporomandibular disorders (TMDs) are complex multifactorial disorders. […] However, there is a paucity of research that aims to identify prognostic factors associated with the clinical outcomes of reversible treatment in people with TMD. […] The objective of this prospective cohort study is to identify prognostic factors that are associated with clinical outcomes of reversible treatment in patients with TMD and to analyse the risk factors that influence the development of chronic TMD. […] The aims of this prospective cohort study are: (1) to identify prognostic factors that are associated with clinical outcomes of reversible treatment in patients with TMD; and (2) to analyse risk factors that influence the development of chronic TMD during a 1-year follow-up period. […] The primary treatment outcome measures will be changes in the anterior maximal opening, worsening of TMD pain assessed using the VAS and changes in pain characteristics.
- #28 External validation of a clinical prediction tool for the use of manual therapy for patients with temporomandibular disorders: a protocol for a prospective observational studyhttps://pmc.ncbi.nlm.nih.gov/articles/PMC10351239/
The purpose of this study is to externally validate the prediction model in a new cohort (temporal validation) of patients with TMD. […] If the performance of the clinical prediction tool in a new sample will be satisfactory, the knowledge gained from this validation study will facilitate clinical decision-making for manual therapists managing people with TMD, which will ultimately enhance patient outcomes. […] Pain intensity will be the primary outcome since patients with TMD commonly identify pain as their main problem. […] According to the Initiative on Methods, Measurement and Pain Assessment in Clinical Trials recommendations about TMD, a pain VAS score reduction of at least 30% is clinically significant. […] Pain intensity during MMO, positive expectations, pain localised to the craniocervical region and a low CSI score predicted significant pain reduction following the MTP.
- #29https://www.jofph.com/articles/10.11607/ofph.23.3.08
Aims: To investigate whether any of the pretreatment physical signs, symptoms, and responses on psychological questionnaires would predict treatment outcomes after a standardized temporomandibular disorder (TMD) treatment program. […] The corollary of these results suggests that if a high degree of jaw function interference is present (eg, clicking, locking), then the prognosis of improvement with brief self-directed physical therapy, an occlusal appliance, and OTC NSAID is lower, at least within the time frame of this study.