Suchość w ustach – Rokowania, prognozy i postęp choroby

Suchość w ustach
Rokowania, prognozy i postęp choroby

Kserostomia, czyli suchość w ustach, jest objawem o wieloczynnikowej etiologii, często występującym u osób starszych (30% powyżej 65. roku życia, 40% powyżej 80. roku życia) oraz u pacjentów onkologicznych, zwłaszcza z nowotworami głowy i szyi, u których ryzyko rozwoju suchości sięga 90-100%. Przepływ śliny niestymulowanej (UFR) stanowi istotny wskaźnik prognostyczny, szczególnie u osób powyżej 60. roku życia. Etiologia kserostomii, obejmująca radioterapię, chemioterapię, leki oraz choroby autoimmunologiczne, wpływa na rokowanie i przebieg choroby. U pacjentów z pierwotnym zespołem Sjögrena suchość ma charakter przewlekły i wymaga długoterminowego zarządzania. W populacji ogólnej częstość kserostomii wynosi około 20%, wzrastając do 50% u osób starszych, co wiąże się z obniżonym UFR, współistniejącymi chorobami i polipragmazją.

Prognoza i przewidywanie wyniku suchości w ustach

Czynniki wpływające na prognozę
Prognozy dla różnych grup pacjentów
Nowe metody przewidywania przebiegu suchości w ustach
Powikłania wpływające na długoterminową prognozę
Czynniki poprawiające prognozę

Wnioski dotyczące prognozy

Kolejne rozdziały

Prognoza i przewidywanie wyniku suchości w ustach

Suchość w ustach, znana również jako kserostomia, jest częstym objawem o wieloczynnikowej etiologii, który może znacząco wpływać na jakość życia pacjentów. Prognozy dotyczące tej dolegliwości różnią się w zależności od przyczyny i skuteczności zastosowanego leczenia.¹² W wielu przypadkach objawy suchości w ustach można z powodzeniem kontrolować, a w niektórych sytuacjach dolegliwość może całkowicie ustąpić. Zazwyczaj jednak znalezienie skutecznego rozwiązania wymaga metody prób i błędów.³

Czynniki wpływające na prognozę

Przewidywanie przebiegu i wyniku suchości w ustach zależy od szeregu czynników, które należy wziąć pod uwagę w ocenie klinicznej:⁴⁵

Wiek pacjenta – częstość występowania kserostomii wzrasta wraz z wiekiem, dotykając około 30% dorosłych powyżej 65 roku życia i 40% dorosłych powyżej 80 roku życia⁶
Natężenie przepływu śliny – wartości przepływu śliny niestymulowanej (UFR) mają większą wartość predykcyjną dla kserostomii niż przepływ śliny stymulowanej (SFR), szczególnie u pacjentów powyżej 60 roku życia⁷
Przyczyna suchości w ustach – różne rokowanie w zależności od tego, czy kserostomia jest wywołana radioterapią, chemioterapią, lekami, chorobami autoimmunologicznymi czy innymi czynnikami⁸⁹
Predyspozycje genetyczne – wstępne badania sugerują istnienie genetycznej podatności na kserostomię, co może wpływać na rokowanie u określonych pacjentów¹⁰¹¹

Prognozy dla różnych grup pacjentów

Przewidywanie wyników leczenia suchości w ustach różni się znacząco w zależności od populacji pacjentów:¹²

Pacjenci onkologiczni

U pacjentów onkologicznych, szczególnie z nowotworami głowy i szyi, suchość w ustach stanowi poważny problem prognostyczny:¹³

Około 1/3 do 1/2 wszystkich pacjentów z chorobą nowotworową rozwija powikłania związane z suchością w ustach w wyniku radioterapii, chemioterapii i leczenia farmakologicznego¹⁴
Pacjenci z nowotworami głowy i szyi mają 90-100% prawdopodobieństwo rozwoju suchości w ustach¹⁵
Radioterapia może trwale uszkodzić gruczoły ślinowe, prowadząc do permanentnej suchości w ustach¹⁶
Chemioterapia może powodować zagęszczenie śliny¹⁷
U pacjentów z terminalną chorobą nowotworową subiektywne odczucie suchości w ustach nie jest wiarygodnym wskaźnikiem prognostycznym faktycznej suchości jamy ustnej, co utrudnia odpowiednie zarządzanie symptomami¹⁸

Pacjenci z zespołem Sjögrena

U osób z pierwotnym zespołem Sjögrena (pSS) kserostomia dotyka ponad 95% pacjentów i ma zazwyczaj charakter przewlekły, wymagający długoterminowego zarządzania objawami.¹⁹ Prognozy dla tych pacjentów koncentrują się na kontrolowaniu objawów i zapobieganiu powikłaniom związanym z przewlekłą suchością jamy ustnej.

Osoby starsze

Częstość występowania kserostomii w populacji ogólnej wynosi około 20%, wzrastając do 30% u kobiet i aż do 50% u osób starszych.²⁰ Z wiekiem prognoza suchości w ustach staje się mniej korzystna ze względu na:²¹²²

Zmniejszony przepływ śliny niestymulowanej (UFR), który znacząco spada wraz z wiekiem²³
Współistniejące choroby przewlekłe i stosowanie wielu leków²⁴
Gorszy stan zdrowia jamy ustnej, który może dodatkowo pogarszać objawy²⁵

Nowe metody przewidywania przebiegu suchości w ustach

Współczesne badania dostarczają nowych narzędzi do przewidywania przebiegu i ryzyka kserostomii:²⁶²⁷

Uczenie maszynowe – algorytmy sztucznej inteligencji, takie jak wielowarstwowy perceptron (MLP), łączące dane UFR i SFR, wykazują znacząco lepszą dokładność przewidywania kserostomii niż każdy z tych parametrów osobno²⁸
Diagnostyka obrazowa języka – badania wykazały wysoką korelację (r = 0,9482) między szacowanym wydzielaniem śliny przez gruczoły ślinowe a cechami obrazu języka, według równania liniowego y = 0,9244x + 2,1664²⁹
Markery genetyczne – zidentyfikowano potencjalne warianty genetyczne związane z kserostomią, w tym geny ANTXR1, RTP1, GLT1D1, NLRP9 i EGFLAM, które mogą wpływać na indywidualne ryzyko i przebieg choroby³⁰
Metabolomika śliny – odrębne profile metaboliczne dla pacjentów z nowotworami głowy i szyi oraz zespołem Sjögrena mogą pomóc w przewidywaniu przebiegu suchości w ustach i jej patofizjologii³¹

Powikłania wpływające na długoterminową prognozę

Przewlekła suchość w ustach zwiększa ryzyko wystąpienia szeregu powikłań, które mogą negatywnie wpłynąć na długoterminową prognozę:³²³³

Próchnica zębów – zwiększone ryzyko ze względu na zmniejszoną ilość śliny o właściwościach ochronnych³⁴
Choroba przyzębia – większa podatność na zapalenie dziąseł i przyzębia³⁵
Owrzodzenia jamy ustnej – częstsze występowanie bolesnych zmian na błonie śluzowej³⁶
Pęknięcia warg – bolesne uszkodzenia prowadzące do dyskomfortu³⁷
Kandydoza jamy ustnej – zwiększone ryzyko infekcji grzybiczej³⁸
Poważne infekcje jamy ustnej – mogą prowadzić do utraty zębów i trudności w noszeniu protez³⁹
Zaburzenia mowy, jedzenia i połykania – znacząco wpływające na jakość życia pacjentów⁴⁰

Czynniki poprawiające prognozę

Pomimo potencjalnych komplikacji, istnieją czynniki, które mogą korzystnie wpłynąć na prognozę suchości w ustach:⁴¹⁴²

Indywidualizacja leczenia – dostosowanie terapii do konkretnych potrzeb i przyczyn suchości w ustach⁴³
Stosowanie substytutów śliny – regularne nawilżanie jamy ustnej⁴⁴
Techniki mechanicznej stymulacji – wspomagające wydzielanie naturalnej śliny⁴⁵
Unikanie czynników wyzwalających – które nasilają suchość w ustach⁴⁶
Regularna kontrola stomatologiczna – wczesne wykrywanie i leczenie powikłań⁴⁷
Wdrażanie zalecanych terapii – zgodnie z wytycznymi klinicznymi⁴⁸

Wnioski dotyczące prognozy

Prognoza suchości w ustach zależy od złożonej interakcji czynników, takich jak wiek pacjenta, przyczyna suchości, stopień uszkodzenia gruczołów ślinowych oraz zastosowane leczenie.⁴⁹⁵⁰ W przypadku przejściowych form suchości w ustach, wywoływanych przez odwracalne czynniki, prognoza jest zazwyczaj dobra. Natomiast w przypadku przewlekłych form kserostomii, jak te spowodowane radioterapią czy chorobami autoimmunologicznymi, prognoza koncentruje się na skutecznym zarządzaniu objawami i zapobieganiu powikłaniom.⁵¹

Nowatorskie metody prognozowania, oparte na analizie danych, biomarkerach i technologiach obrazowania, oferują obiecującą przyszłość w zakresie personalizacji oceny ryzyka i przewidywania przebiegu suchości w ustach, co może znacząco poprawić jakość życia pacjentów cierpiących na tę dolegliwość.⁵²⁵³

Kolejne rozdziały

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Wybierz kolejny rozdział z menu poniżej, aby otworzyć nową podstronę kompedium wiedzy i uzyskać szczegółowe informację o leku, substancji lub chorobie.

Materiały źródłowe

#1 Saliva Metabolomics in Dry Mouth Patients with Head and Neck Cancer or SjÃ¶grenâs Syndrome
https://www.mdpi.com/2073-4409/11/3/323
The etiology of dry mouth conditions is multi-faceted. Patients radiated after head and neck cancer (HNC) and those with primary SjÃ¶grenâs syndrome (pSS) share many of the same symptoms despite different causes. […] Dry mouth may lead to deteriorated oral health, including caries, Candida infection, distorted taste, and pronounced difficulties with speech and swallowing, severely reducing the personâs quality of life. Dry mouth affects >95% of head and neck cancer (HNC) patients treated with radiotherapy and patients with the autoimmune disease primary SjÃ¶grenâs syndrome (pSS). […] In conclusion, we showed separate metabolic profiles for HNC and pSS patients as compared to controls that could be useful for elucidating the differences in pathophysiology in groups suffering from dry mouth. The demonstrated dysregulation of pyrimidine nucleotides and levels of metabolites derived from amino acids in the patient groups remain to be investigated further.
#2 Dry Mouth (Xerostomia): Causes, Symptoms & Treatment
https://my.clevelandclinic.org/health/diseases/10902-dry-mouth-xerostomia
You can successfully manage dry mouth symptoms with treatment. And in some cases, xerostomia may go away completely. Most of the time, it takes trial and error to figure out a solution. Your provider may adjust your medications. Or they may refer you to a specialist if they suspect you have an underlying condition. […] When you have chronic dry mouth, you’re more likely to develop: cavities, gum disease, mouth sores, cracked lips, oral thrush.
#3 Dry Mouth (Xerostomia): Causes, Symptoms & Treatment
https://my.clevelandclinic.org/health/diseases/10902-dry-mouth-xerostomia
You can successfully manage dry mouth symptoms with treatment. And in some cases, xerostomia may go away completely. Most of the time, it takes trial and error to figure out a solution. Your provider may adjust your medications. Or they may refer you to a specialist if they suspect you have an underlying condition. […] When you have chronic dry mouth, you’re more likely to develop: cavities, gum disease, mouth sores, cracked lips, oral thrush.
#4 Prediction of xerostomia in elderly based on clinical characteristics and salivary flow rate with machine learning | Scientific Reports
https://www.nature.com/articles/s41598-024-54120-x
Xerostomia may be accompanied by changes in salivary flow rate and the incidence increases in elderly. […] This study is the first to predict xerostomia with salivary flow rate in elderly based on artificial intelligence. […] The incidence of xerostomia increased with age. […] In patients more than 60 years of age, the UFR had a significantly higher predictive accuracy for xerostomia than the SFR. […] Xerostomia is a major concern and significantly reduces quality of life. […] The exact incidence of xerostomia is unknown, but it ranges from 0.9 to 64.8% in the general population and occurs in approximately 30% of adults over 65 years of age and 40% of adults over 80 years of age. […] The incidence of xerostomia is higher in the geriatric population than in younger adults. […] The causes of xerostomia in the older population have been attributed to local factors, such as poor dental health and infection of the mouth, as well as chronic systemic diseases or autoimmune diseases.
#5 Prediction of xerostomia in elderly based on clinical characteristics and salivary flow rate with machine learning | Scientific Reports
https://www.nature.com/articles/s41598-024-54120-x
Xerostomia can also seriously impact the quality of life and may alter speech, eating, and swallowing. […] The UFR, but not SFR, decreased with age significantly. […] The UFR had a significantly higher predictive accuracy for xerostomia than the SFR. […] The prediction accuracy of the multilayer perceptron (MLP) algorithm that combined UFR and SFR data was significantly better than either UFR or SFR individually. […] Significant predictors of xerostomia were obtained from logistic regression analysis, and the degree to which they contributed was estimated using weight=log odds ratio values. […] The main predictor of xerostomia was age. […] The risk of xerostomia increased with age. […] The prediction of xerostomia by the UFR was significant in patients aged over 60 years. […] The UFR contributes more significantly to the prediction of xerostomia than the SFR, and the weight of the UFR is higher in older people.
#6 Prediction of xerostomia in elderly based on clinical characteristics and salivary flow rate with machine learning | Scientific Reports
https://www.nature.com/articles/s41598-024-54120-x
Xerostomia may be accompanied by changes in salivary flow rate and the incidence increases in elderly. […] This study is the first to predict xerostomia with salivary flow rate in elderly based on artificial intelligence. […] The incidence of xerostomia increased with age. […] In patients more than 60 years of age, the UFR had a significantly higher predictive accuracy for xerostomia than the SFR. […] Xerostomia is a major concern and significantly reduces quality of life. […] The exact incidence of xerostomia is unknown, but it ranges from 0.9 to 64.8% in the general population and occurs in approximately 30% of adults over 65 years of age and 40% of adults over 80 years of age. […] The incidence of xerostomia is higher in the geriatric population than in younger adults. […] The causes of xerostomia in the older population have been attributed to local factors, such as poor dental health and infection of the mouth, as well as chronic systemic diseases or autoimmune diseases.
#7 Prediction of xerostomia in elderly based on clinical characteristics and salivary flow rate with machine learning | Scientific Reports
https://www.nature.com/articles/s41598-024-54120-x
Xerostomia can also seriously impact the quality of life and may alter speech, eating, and swallowing. […] The UFR, but not SFR, decreased with age significantly. […] The UFR had a significantly higher predictive accuracy for xerostomia than the SFR. […] The prediction accuracy of the multilayer perceptron (MLP) algorithm that combined UFR and SFR data was significantly better than either UFR or SFR individually. […] Significant predictors of xerostomia were obtained from logistic regression analysis, and the degree to which they contributed was estimated using weight=log odds ratio values. […] The main predictor of xerostomia was age. […] The risk of xerostomia increased with age. […] The prediction of xerostomia by the UFR was significant in patients aged over 60 years. […] The UFR contributes more significantly to the prediction of xerostomia than the SFR, and the weight of the UFR is higher in older people.
#8 Saliva Metabolomics in Dry Mouth Patients with Head and Neck Cancer or SjÃ¶grenâs Syndrome
https://www.mdpi.com/2073-4409/11/3/323
The etiology of dry mouth conditions is multi-faceted. Patients radiated after head and neck cancer (HNC) and those with primary SjÃ¶grenâs syndrome (pSS) share many of the same symptoms despite different causes. […] Dry mouth may lead to deteriorated oral health, including caries, Candida infection, distorted taste, and pronounced difficulties with speech and swallowing, severely reducing the personâs quality of life. Dry mouth affects >95% of head and neck cancer (HNC) patients treated with radiotherapy and patients with the autoimmune disease primary SjÃ¶grenâs syndrome (pSS). […] In conclusion, we showed separate metabolic profiles for HNC and pSS patients as compared to controls that could be useful for elucidating the differences in pathophysiology in groups suffering from dry mouth. The demonstrated dysregulation of pyrimidine nucleotides and levels of metabolites derived from amino acids in the patient groups remain to be investigated further.
#9 Dry mouth and cancer | EBSCO Research Starters
https://www.ebsco.com/research-starters/health-and-medicine/dry-mouth-and-cancer
Approximately one-third to one-half of all cancer patients develop dry mouth complications because of radiation therapy, chemotherapy, and medication treatments. […] Patients with specific types of cancer, such as head and neck cancers, are between 90 and 100 percent likely to develop dry mouth. […] Dry mouth can be a temporary or permanent situation depending on its cause. Radiation therapy can permanently damage salivary glands, and chemotherapy can cause saliva to become thick. […] Serious oral infections and extensive decay may result in loss of teeth and difficulty wearing dentures. […] By avoiding the triggers that provoke dry mouth and using the recommended treatments, dry mouth may be manageable.
#10 Genetic susceptibility to patient-reported xerostomia among long-term oropharyngeal cancer survivors | Scientific Reports
https://www.nature.com/articles/s41598-022-10538-9
Genetic susceptibility for xerostomia, a common sequela of radiotherapy and chemoradiotherapy for head and neck cancer, is unknown. Therefore, to identify genetic variants associated with moderate to severe xerostomia, we conducted a GWAS of 359 long-term oropharyngeal cancer (OPC) survivors using 579,956 autosomal SNPs. In our study, 39.2% of OPC survivors reported moderate to severe xerostomia. Our GWAS identified eight SNPs suggestively associated with higher risk of moderate to severe xerostomia in six genomic regions (2p13.3, rs6546481, Minor Allele (MA)=A, ANTXR1, P=4.3107; 5p13.2p13.1, rs16903936, MA=G, EGFLAM, P=5.1106; 4q21.1, rs10518156, MA=G, SHROOM3, P=7.1106; 19q13.42, rs11882068, MA=G, NLRP9, P=1.7105; 12q24.33, rs4760542, MA=G, GLT1D1, P=1.8105; and 3q27.3, rs11714564, MA=G, RTP1, P=2.9105. Seven SNPs were associated with lower risk of moderate to severe xerostomia, of which only one mapped to specific genomic region (15q21.3, rs4776140, MA=G, LOC105370826, a ncRNA class RNA gene, P=1.5105). Although our small exploratory study did not reach genome-wide statistical significance, our study provides, for the first time, preliminary evidence of genetic susceptibility to xerostomia. Further studies are needed to elucidate the role of genetic susceptibility to xerostomia.
#11 Genetic susceptibility to patient-reported xerostomia among long-term oropharyngeal cancer survivors | Scientific Reports
https://www.nature.com/articles/s41598-022-10538-9
Xerostomia is a common complication/sequela of HNC treatment often resulting in functional impairment and debilitating morbidity. To the best of our knowledge, this is the first study to conduct a genome-wide association analysis to identify genetic variants associated with risk of moderate to severe patient-reported xerostomia among OPC survivors. In this small exploratory GWAS study, we identified 15 SNPs with potential associations with moderate to severe xerostomia; seven of the SNPs belong to specific genomic regions (2p13.3, 3q27.3, 4q21.1, 5p13.2p13.1, 12q24.33, 15q21.3, 19q13.42). Of the 15 variants, 8 were associated with higher risk, and 7 were associated with lowering risk of moderate to severe xerostomia. The most prominent findings in our study included potential associations of ANTXR1, RTP1, GLT1D1, NLRP9, and EGFLAM genes with xerostomia. Although our small sample study did not reach the genome-wide statistical significance (5.0108), our study provides preliminary evidence of genetic basis for xerostomia which needs to be validated in independent studies.
#12 Dry mouth and cancer | EBSCO Research Starters
https://www.ebsco.com/research-starters/health-and-medicine/dry-mouth-and-cancer
Approximately one-third to one-half of all cancer patients develop dry mouth complications because of radiation therapy, chemotherapy, and medication treatments. […] Patients with specific types of cancer, such as head and neck cancers, are between 90 and 100 percent likely to develop dry mouth. […] Dry mouth can be a temporary or permanent situation depending on its cause. Radiation therapy can permanently damage salivary glands, and chemotherapy can cause saliva to become thick. […] Serious oral infections and extensive decay may result in loss of teeth and difficulty wearing dentures. […] By avoiding the triggers that provoke dry mouth and using the recommended treatments, dry mouth may be manageable.
#13 Dry mouth and cancer | EBSCO Research Starters
https://www.ebsco.com/research-starters/health-and-medicine/dry-mouth-and-cancer
Approximately one-third to one-half of all cancer patients develop dry mouth complications because of radiation therapy, chemotherapy, and medication treatments. […] Patients with specific types of cancer, such as head and neck cancers, are between 90 and 100 percent likely to develop dry mouth. […] Dry mouth can be a temporary or permanent situation depending on its cause. Radiation therapy can permanently damage salivary glands, and chemotherapy can cause saliva to become thick. […] Serious oral infections and extensive decay may result in loss of teeth and difficulty wearing dentures. […] By avoiding the triggers that provoke dry mouth and using the recommended treatments, dry mouth may be manageable.
#14 Dry mouth and cancer | EBSCO Research Starters
https://www.ebsco.com/research-starters/health-and-medicine/dry-mouth-and-cancer
Approximately one-third to one-half of all cancer patients develop dry mouth complications because of radiation therapy, chemotherapy, and medication treatments. […] Patients with specific types of cancer, such as head and neck cancers, are between 90 and 100 percent likely to develop dry mouth. […] Dry mouth can be a temporary or permanent situation depending on its cause. Radiation therapy can permanently damage salivary glands, and chemotherapy can cause saliva to become thick. […] Serious oral infections and extensive decay may result in loss of teeth and difficulty wearing dentures. […] By avoiding the triggers that provoke dry mouth and using the recommended treatments, dry mouth may be manageable.
#15 Dry mouth and cancer | EBSCO Research Starters
https://www.ebsco.com/research-starters/health-and-medicine/dry-mouth-and-cancer
Approximately one-third to one-half of all cancer patients develop dry mouth complications because of radiation therapy, chemotherapy, and medication treatments. […] Patients with specific types of cancer, such as head and neck cancers, are between 90 and 100 percent likely to develop dry mouth. […] Dry mouth can be a temporary or permanent situation depending on its cause. Radiation therapy can permanently damage salivary glands, and chemotherapy can cause saliva to become thick. […] Serious oral infections and extensive decay may result in loss of teeth and difficulty wearing dentures. […] By avoiding the triggers that provoke dry mouth and using the recommended treatments, dry mouth may be manageable.
#16 Dry mouth and cancer | EBSCO Research Starters
https://www.ebsco.com/research-starters/health-and-medicine/dry-mouth-and-cancer
Approximately one-third to one-half of all cancer patients develop dry mouth complications because of radiation therapy, chemotherapy, and medication treatments. […] Patients with specific types of cancer, such as head and neck cancers, are between 90 and 100 percent likely to develop dry mouth. […] Dry mouth can be a temporary or permanent situation depending on its cause. Radiation therapy can permanently damage salivary glands, and chemotherapy can cause saliva to become thick. […] Serious oral infections and extensive decay may result in loss of teeth and difficulty wearing dentures. […] By avoiding the triggers that provoke dry mouth and using the recommended treatments, dry mouth may be manageable.
#17 Dry mouth and cancer | EBSCO Research Starters
https://www.ebsco.com/research-starters/health-and-medicine/dry-mouth-and-cancer
Approximately one-third to one-half of all cancer patients develop dry mouth complications because of radiation therapy, chemotherapy, and medication treatments. […] Patients with specific types of cancer, such as head and neck cancers, are between 90 and 100 percent likely to develop dry mouth. […] Dry mouth can be a temporary or permanent situation depending on its cause. Radiation therapy can permanently damage salivary glands, and chemotherapy can cause saliva to become thick. […] Serious oral infections and extensive decay may result in loss of teeth and difficulty wearing dentures. […] By avoiding the triggers that provoke dry mouth and using the recommended treatments, dry mouth may be manageable.
#18 Diagnostic accuracy of patient-reported dry mouth as a predictor for oral dryness in terminally ill cancer patients – PubMed
https://pubmed.ncbi.nlm.nih.gov/32989524/
Purpose: The aim of the study was to determine the diagnostic accuracy of patient-reported dry mouth using an oral moisture-checking device in terminally ill cancer patients. […] Results: Of 103 participants, the prevalence of oral dryness was 65.0%. ROC analysis indicated that patient-reported dry mouth was a poor predictor of oral dryness, with an area under the curve of 0.616 (95% confidence interval: 0.508-0.723), a sensitivity of 46.3%, a specificity of 75.8%, a PPV of 55.9%, an NPV of 68.1, a positive LR of 1.9, a negative LR of 0.7, and an overall diagnostic accuracy of 64.1%, with a cut-off value of 3 points. […] Conclusion: In conclusion, patient-reported dry mouth is not a useful parameter for the assessment of oral dryness in terminally ill cancer patients.
#19 Saliva Metabolomics in Dry Mouth Patients with Head and Neck Cancer or SjÃ¶grenâs Syndrome
https://www.mdpi.com/2073-4409/11/3/323
The etiology of dry mouth conditions is multi-faceted. Patients radiated after head and neck cancer (HNC) and those with primary SjÃ¶grenâs syndrome (pSS) share many of the same symptoms despite different causes. […] Dry mouth may lead to deteriorated oral health, including caries, Candida infection, distorted taste, and pronounced difficulties with speech and swallowing, severely reducing the personâs quality of life. Dry mouth affects >95% of head and neck cancer (HNC) patients treated with radiotherapy and patients with the autoimmune disease primary SjÃ¶grenâs syndrome (pSS). […] In conclusion, we showed separate metabolic profiles for HNC and pSS patients as compared to controls that could be useful for elucidating the differences in pathophysiology in groups suffering from dry mouth. The demonstrated dysregulation of pyrimidine nucleotides and levels of metabolites derived from amino acids in the patient groups remain to be investigated further.
#20 Prediction of Dry Mouth Condition Using Radiomics Features from Tongue Diagnosis Image
https://www.mdpi.com/2076-3417/14/22/10118
Xerostomia, commonly known as dry mouth, is characterized by reduced salivary secretion, which can lead to various oral health issues and discomfort. […] The prevalence of xerostomia is approximately 20% in the general population, rising to 30% in women and up to 50% in the elderly. […] The diagnosis of xerostomia involves several key factors, including symptoms, medication use, past medical history, and oral examination. […] Given these challenges, there is a pressing need for ongoing research and the development of more objective, standardized diagnostic tools. […] In this study, we aimed to predict salivary gland secretion levels using images of the tongue obtained from patients presenting with xerostomia (dry mouth). […] We extracted 462 image features from the cropped tongue image, focusing on both first-order statistics and second-order statistics, which encompass textural features.
#21 Prediction of xerostomia in elderly based on clinical characteristics and salivary flow rate with machine learning | Scientific Reports
https://www.nature.com/articles/s41598-024-54120-x
Xerostomia may be accompanied by changes in salivary flow rate and the incidence increases in elderly. […] This study is the first to predict xerostomia with salivary flow rate in elderly based on artificial intelligence. […] The incidence of xerostomia increased with age. […] In patients more than 60 years of age, the UFR had a significantly higher predictive accuracy for xerostomia than the SFR. […] Xerostomia is a major concern and significantly reduces quality of life. […] The exact incidence of xerostomia is unknown, but it ranges from 0.9 to 64.8% in the general population and occurs in approximately 30% of adults over 65 years of age and 40% of adults over 80 years of age. […] The incidence of xerostomia is higher in the geriatric population than in younger adults. […] The causes of xerostomia in the older population have been attributed to local factors, such as poor dental health and infection of the mouth, as well as chronic systemic diseases or autoimmune diseases.
#22 Prediction of xerostomia in elderly based on clinical characteristics and salivary flow rate with machine learning | Scientific Reports
https://www.nature.com/articles/s41598-024-54120-x
Xerostomia can also seriously impact the quality of life and may alter speech, eating, and swallowing. […] The UFR, but not SFR, decreased with age significantly. […] The UFR had a significantly higher predictive accuracy for xerostomia than the SFR. […] The prediction accuracy of the multilayer perceptron (MLP) algorithm that combined UFR and SFR data was significantly better than either UFR or SFR individually. […] Significant predictors of xerostomia were obtained from logistic regression analysis, and the degree to which they contributed was estimated using weight=log odds ratio values. […] The main predictor of xerostomia was age. […] The risk of xerostomia increased with age. […] The prediction of xerostomia by the UFR was significant in patients aged over 60 years. […] The UFR contributes more significantly to the prediction of xerostomia than the SFR, and the weight of the UFR is higher in older people.
#23 Prediction of xerostomia in elderly based on clinical characteristics and salivary flow rate with machine learning | Scientific Reports
https://www.nature.com/articles/s41598-024-54120-x
Xerostomia can also seriously impact the quality of life and may alter speech, eating, and swallowing. […] The UFR, but not SFR, decreased with age significantly. […] The UFR had a significantly higher predictive accuracy for xerostomia than the SFR. […] The prediction accuracy of the multilayer perceptron (MLP) algorithm that combined UFR and SFR data was significantly better than either UFR or SFR individually. […] Significant predictors of xerostomia were obtained from logistic regression analysis, and the degree to which they contributed was estimated using weight=log odds ratio values. […] The main predictor of xerostomia was age. […] The risk of xerostomia increased with age. […] The prediction of xerostomia by the UFR was significant in patients aged over 60 years. […] The UFR contributes more significantly to the prediction of xerostomia than the SFR, and the weight of the UFR is higher in older people.
#24 Prediction of xerostomia in elderly based on clinical characteristics and salivary flow rate with machine learning | Scientific Reports
https://www.nature.com/articles/s41598-024-54120-x
Xerostomia may be accompanied by changes in salivary flow rate and the incidence increases in elderly. […] This study is the first to predict xerostomia with salivary flow rate in elderly based on artificial intelligence. […] The incidence of xerostomia increased with age. […] In patients more than 60 years of age, the UFR had a significantly higher predictive accuracy for xerostomia than the SFR. […] Xerostomia is a major concern and significantly reduces quality of life. […] The exact incidence of xerostomia is unknown, but it ranges from 0.9 to 64.8% in the general population and occurs in approximately 30% of adults over 65 years of age and 40% of adults over 80 years of age. […] The incidence of xerostomia is higher in the geriatric population than in younger adults. […] The causes of xerostomia in the older population have been attributed to local factors, such as poor dental health and infection of the mouth, as well as chronic systemic diseases or autoimmune diseases.
#25 Prediction of xerostomia in elderly based on clinical characteristics and salivary flow rate with machine learning | Scientific Reports
https://www.nature.com/articles/s41598-024-54120-x
Xerostomia may be accompanied by changes in salivary flow rate and the incidence increases in elderly. […] This study is the first to predict xerostomia with salivary flow rate in elderly based on artificial intelligence. […] The incidence of xerostomia increased with age. […] In patients more than 60 years of age, the UFR had a significantly higher predictive accuracy for xerostomia than the SFR. […] Xerostomia is a major concern and significantly reduces quality of life. […] The exact incidence of xerostomia is unknown, but it ranges from 0.9 to 64.8% in the general population and occurs in approximately 30% of adults over 65 years of age and 40% of adults over 80 years of age. […] The incidence of xerostomia is higher in the geriatric population than in younger adults. […] The causes of xerostomia in the older population have been attributed to local factors, such as poor dental health and infection of the mouth, as well as chronic systemic diseases or autoimmune diseases.
#26 Prediction of xerostomia in elderly based on clinical characteristics and salivary flow rate with machine learning | Scientific Reports
https://www.nature.com/articles/s41598-024-54120-x
Xerostomia can also seriously impact the quality of life and may alter speech, eating, and swallowing. […] The UFR, but not SFR, decreased with age significantly. […] The UFR had a significantly higher predictive accuracy for xerostomia than the SFR. […] The prediction accuracy of the multilayer perceptron (MLP) algorithm that combined UFR and SFR data was significantly better than either UFR or SFR individually. […] Significant predictors of xerostomia were obtained from logistic regression analysis, and the degree to which they contributed was estimated using weight=log odds ratio values. […] The main predictor of xerostomia was age. […] The risk of xerostomia increased with age. […] The prediction of xerostomia by the UFR was significant in patients aged over 60 years. […] The UFR contributes more significantly to the prediction of xerostomia than the SFR, and the weight of the UFR is higher in older people.
#27 Prediction of Dry Mouth Condition Using Radiomics Features from Tongue Diagnosis Image
https://www.mdpi.com/2076-3417/14/22/10118
Xerostomia, commonly known as dry mouth, is characterized by reduced salivary secretion, which can lead to various oral health issues and discomfort. […] The prevalence of xerostomia is approximately 20% in the general population, rising to 30% in women and up to 50% in the elderly. […] The diagnosis of xerostomia involves several key factors, including symptoms, medication use, past medical history, and oral examination. […] Given these challenges, there is a pressing need for ongoing research and the development of more objective, standardized diagnostic tools. […] In this study, we aimed to predict salivary gland secretion levels using images of the tongue obtained from patients presenting with xerostomia (dry mouth). […] We extracted 462 image features from the cropped tongue image, focusing on both first-order statistics and second-order statistics, which encompass textural features.
#28 Prediction of xerostomia in elderly based on clinical characteristics and salivary flow rate with machine learning | Scientific Reports
https://www.nature.com/articles/s41598-024-54120-x
Xerostomia can also seriously impact the quality of life and may alter speech, eating, and swallowing. […] The UFR, but not SFR, decreased with age significantly. […] The UFR had a significantly higher predictive accuracy for xerostomia than the SFR. […] The prediction accuracy of the multilayer perceptron (MLP) algorithm that combined UFR and SFR data was significantly better than either UFR or SFR individually. […] Significant predictors of xerostomia were obtained from logistic regression analysis, and the degree to which they contributed was estimated using weight=log odds ratio values. […] The main predictor of xerostomia was age. […] The risk of xerostomia increased with age. […] The prediction of xerostomia by the UFR was significant in patients aged over 60 years. […] The UFR contributes more significantly to the prediction of xerostomia than the SFR, and the weight of the UFR is higher in older people.
#29 Prediction of Dry Mouth Condition Using Radiomics Features from Tongue Diagnosis Image
https://www.mdpi.com/2076-3417/14/22/10118
The estimated linear equation was given by y = 0.9244x + 2.1664. […] Despite challenges such as issues with image focus, skewed data, and a limited dataset, the results demonstrated a high correlation (r = 0.9482) between the estimated salivary gland secretion and the tongue image features. […] Our findings will open up avenues for future research that harnesses the potential of tongue imaging in clinical practice.
#30 Genetic susceptibility to patient-reported xerostomia among long-term oropharyngeal cancer survivors | Scientific Reports
https://www.nature.com/articles/s41598-022-10538-9
Xerostomia is a common complication/sequela of HNC treatment often resulting in functional impairment and debilitating morbidity. To the best of our knowledge, this is the first study to conduct a genome-wide association analysis to identify genetic variants associated with risk of moderate to severe patient-reported xerostomia among OPC survivors. In this small exploratory GWAS study, we identified 15 SNPs with potential associations with moderate to severe xerostomia; seven of the SNPs belong to specific genomic regions (2p13.3, 3q27.3, 4q21.1, 5p13.2p13.1, 12q24.33, 15q21.3, 19q13.42). Of the 15 variants, 8 were associated with higher risk, and 7 were associated with lowering risk of moderate to severe xerostomia. The most prominent findings in our study included potential associations of ANTXR1, RTP1, GLT1D1, NLRP9, and EGFLAM genes with xerostomia. Although our small sample study did not reach the genome-wide statistical significance (5.0108), our study provides preliminary evidence of genetic basis for xerostomia which needs to be validated in independent studies.
#31 Saliva Metabolomics in Dry Mouth Patients with Head and Neck Cancer or SjÃ¶grenâs Syndrome
https://www.mdpi.com/2073-4409/11/3/323
The etiology of dry mouth conditions is multi-faceted. Patients radiated after head and neck cancer (HNC) and those with primary SjÃ¶grenâs syndrome (pSS) share many of the same symptoms despite different causes. […] Dry mouth may lead to deteriorated oral health, including caries, Candida infection, distorted taste, and pronounced difficulties with speech and swallowing, severely reducing the personâs quality of life. Dry mouth affects >95% of head and neck cancer (HNC) patients treated with radiotherapy and patients with the autoimmune disease primary SjÃ¶grenâs syndrome (pSS). […] In conclusion, we showed separate metabolic profiles for HNC and pSS patients as compared to controls that could be useful for elucidating the differences in pathophysiology in groups suffering from dry mouth. The demonstrated dysregulation of pyrimidine nucleotides and levels of metabolites derived from amino acids in the patient groups remain to be investigated further.
#32 Dry Mouth (Xerostomia): Causes, Symptoms & Treatment
https://my.clevelandclinic.org/health/diseases/10902-dry-mouth-xerostomia
You can successfully manage dry mouth symptoms with treatment. And in some cases, xerostomia may go away completely. Most of the time, it takes trial and error to figure out a solution. Your provider may adjust your medications. Or they may refer you to a specialist if they suspect you have an underlying condition. […] When you have chronic dry mouth, you’re more likely to develop: cavities, gum disease, mouth sores, cracked lips, oral thrush.
#33 Dry mouth and cancer | EBSCO Research Starters
https://www.ebsco.com/research-starters/health-and-medicine/dry-mouth-and-cancer
Approximately one-third to one-half of all cancer patients develop dry mouth complications because of radiation therapy, chemotherapy, and medication treatments. […] Patients with specific types of cancer, such as head and neck cancers, are between 90 and 100 percent likely to develop dry mouth. […] Dry mouth can be a temporary or permanent situation depending on its cause. Radiation therapy can permanently damage salivary glands, and chemotherapy can cause saliva to become thick. […] Serious oral infections and extensive decay may result in loss of teeth and difficulty wearing dentures. […] By avoiding the triggers that provoke dry mouth and using the recommended treatments, dry mouth may be manageable.
#34 Dry Mouth (Xerostomia): Causes, Symptoms & Treatment
https://my.clevelandclinic.org/health/diseases/10902-dry-mouth-xerostomia
You can successfully manage dry mouth symptoms with treatment. And in some cases, xerostomia may go away completely. Most of the time, it takes trial and error to figure out a solution. Your provider may adjust your medications. Or they may refer you to a specialist if they suspect you have an underlying condition. […] When you have chronic dry mouth, you’re more likely to develop: cavities, gum disease, mouth sores, cracked lips, oral thrush.
#35 Dry Mouth (Xerostomia): Causes, Symptoms & Treatment
https://my.clevelandclinic.org/health/diseases/10902-dry-mouth-xerostomia
You can successfully manage dry mouth symptoms with treatment. And in some cases, xerostomia may go away completely. Most of the time, it takes trial and error to figure out a solution. Your provider may adjust your medications. Or they may refer you to a specialist if they suspect you have an underlying condition. […] When you have chronic dry mouth, you’re more likely to develop: cavities, gum disease, mouth sores, cracked lips, oral thrush.
#36 Dry Mouth (Xerostomia): Causes, Symptoms & Treatment
https://my.clevelandclinic.org/health/diseases/10902-dry-mouth-xerostomia
You can successfully manage dry mouth symptoms with treatment. And in some cases, xerostomia may go away completely. Most of the time, it takes trial and error to figure out a solution. Your provider may adjust your medications. Or they may refer you to a specialist if they suspect you have an underlying condition. […] When you have chronic dry mouth, you’re more likely to develop: cavities, gum disease, mouth sores, cracked lips, oral thrush.
#37 Dry Mouth (Xerostomia): Causes, Symptoms & Treatment
https://my.clevelandclinic.org/health/diseases/10902-dry-mouth-xerostomia
You can successfully manage dry mouth symptoms with treatment. And in some cases, xerostomia may go away completely. Most of the time, it takes trial and error to figure out a solution. Your provider may adjust your medications. Or they may refer you to a specialist if they suspect you have an underlying condition. […] When you have chronic dry mouth, you’re more likely to develop: cavities, gum disease, mouth sores, cracked lips, oral thrush.
#38 Dry Mouth (Xerostomia): Causes, Symptoms & Treatment
https://my.clevelandclinic.org/health/diseases/10902-dry-mouth-xerostomia
You can successfully manage dry mouth symptoms with treatment. And in some cases, xerostomia may go away completely. Most of the time, it takes trial and error to figure out a solution. Your provider may adjust your medications. Or they may refer you to a specialist if they suspect you have an underlying condition. […] When you have chronic dry mouth, you’re more likely to develop: cavities, gum disease, mouth sores, cracked lips, oral thrush.
#39 Dry mouth and cancer | EBSCO Research Starters
https://www.ebsco.com/research-starters/health-and-medicine/dry-mouth-and-cancer
Approximately one-third to one-half of all cancer patients develop dry mouth complications because of radiation therapy, chemotherapy, and medication treatments. […] Patients with specific types of cancer, such as head and neck cancers, are between 90 and 100 percent likely to develop dry mouth. […] Dry mouth can be a temporary or permanent situation depending on its cause. Radiation therapy can permanently damage salivary glands, and chemotherapy can cause saliva to become thick. […] Serious oral infections and extensive decay may result in loss of teeth and difficulty wearing dentures. […] By avoiding the triggers that provoke dry mouth and using the recommended treatments, dry mouth may be manageable.
#40 Prediction of xerostomia in elderly based on clinical characteristics and salivary flow rate with machine learning | Scientific Reports
https://www.nature.com/articles/s41598-024-54120-x
Xerostomia can also seriously impact the quality of life and may alter speech, eating, and swallowing. […] The UFR, but not SFR, decreased with age significantly. […] The UFR had a significantly higher predictive accuracy for xerostomia than the SFR. […] The prediction accuracy of the multilayer perceptron (MLP) algorithm that combined UFR and SFR data was significantly better than either UFR or SFR individually. […] Significant predictors of xerostomia were obtained from logistic regression analysis, and the degree to which they contributed was estimated using weight=log odds ratio values. […] The main predictor of xerostomia was age. […] The risk of xerostomia increased with age. […] The prediction of xerostomia by the UFR was significant in patients aged over 60 years. […] The UFR contributes more significantly to the prediction of xerostomia than the SFR, and the weight of the UFR is higher in older people.
#41 [Prognosis and treatment of dry mouth. Systematic review] – PubMed
https://pubmed.ncbi.nlm.nih.gov/23726507/
There are no clearly established protocols for the treatment of dry mouth. The aim of this paper is a systematic review of the literature of the past 10 years using the words dry mouth, prognosis, treatment and dentistry. […] It can be concluded that treatment must be individualized, salivary substitutes and mechanical stimulation techniques can be applied.
#42 Dry mouth and cancer | EBSCO Research Starters
https://www.ebsco.com/research-starters/health-and-medicine/dry-mouth-and-cancer
Approximately one-third to one-half of all cancer patients develop dry mouth complications because of radiation therapy, chemotherapy, and medication treatments. […] Patients with specific types of cancer, such as head and neck cancers, are between 90 and 100 percent likely to develop dry mouth. […] Dry mouth can be a temporary or permanent situation depending on its cause. Radiation therapy can permanently damage salivary glands, and chemotherapy can cause saliva to become thick. […] Serious oral infections and extensive decay may result in loss of teeth and difficulty wearing dentures. […] By avoiding the triggers that provoke dry mouth and using the recommended treatments, dry mouth may be manageable.
#43 [Prognosis and treatment of dry mouth. Systematic review] – PubMed
https://pubmed.ncbi.nlm.nih.gov/23726507/
There are no clearly established protocols for the treatment of dry mouth. The aim of this paper is a systematic review of the literature of the past 10 years using the words dry mouth, prognosis, treatment and dentistry. […] It can be concluded that treatment must be individualized, salivary substitutes and mechanical stimulation techniques can be applied.
#44 [Prognosis and treatment of dry mouth. Systematic review] – PubMed
https://pubmed.ncbi.nlm.nih.gov/23726507/
There are no clearly established protocols for the treatment of dry mouth. The aim of this paper is a systematic review of the literature of the past 10 years using the words dry mouth, prognosis, treatment and dentistry. […] It can be concluded that treatment must be individualized, salivary substitutes and mechanical stimulation techniques can be applied.
#45 [Prognosis and treatment of dry mouth. Systematic review] – PubMed
https://pubmed.ncbi.nlm.nih.gov/23726507/
There are no clearly established protocols for the treatment of dry mouth. The aim of this paper is a systematic review of the literature of the past 10 years using the words dry mouth, prognosis, treatment and dentistry. […] It can be concluded that treatment must be individualized, salivary substitutes and mechanical stimulation techniques can be applied.
#46 Dry mouth and cancer | EBSCO Research Starters
https://www.ebsco.com/research-starters/health-and-medicine/dry-mouth-and-cancer
Approximately one-third to one-half of all cancer patients develop dry mouth complications because of radiation therapy, chemotherapy, and medication treatments. […] Patients with specific types of cancer, such as head and neck cancers, are between 90 and 100 percent likely to develop dry mouth. […] Dry mouth can be a temporary or permanent situation depending on its cause. Radiation therapy can permanently damage salivary glands, and chemotherapy can cause saliva to become thick. […] Serious oral infections and extensive decay may result in loss of teeth and difficulty wearing dentures. […] By avoiding the triggers that provoke dry mouth and using the recommended treatments, dry mouth may be manageable.
#47 Dry Mouth (Xerostomia): Causes, Symptoms & Treatment
https://my.clevelandclinic.org/health/diseases/10902-dry-mouth-xerostomia
You can successfully manage dry mouth symptoms with treatment. And in some cases, xerostomia may go away completely. Most of the time, it takes trial and error to figure out a solution. Your provider may adjust your medications. Or they may refer you to a specialist if they suspect you have an underlying condition. […] When you have chronic dry mouth, you’re more likely to develop: cavities, gum disease, mouth sores, cracked lips, oral thrush.
#48 Dry mouth and cancer | EBSCO Research Starters
https://www.ebsco.com/research-starters/health-and-medicine/dry-mouth-and-cancer
Approximately one-third to one-half of all cancer patients develop dry mouth complications because of radiation therapy, chemotherapy, and medication treatments. […] Patients with specific types of cancer, such as head and neck cancers, are between 90 and 100 percent likely to develop dry mouth. […] Dry mouth can be a temporary or permanent situation depending on its cause. Radiation therapy can permanently damage salivary glands, and chemotherapy can cause saliva to become thick. […] Serious oral infections and extensive decay may result in loss of teeth and difficulty wearing dentures. […] By avoiding the triggers that provoke dry mouth and using the recommended treatments, dry mouth may be manageable.
#49 Prediction of xerostomia in elderly based on clinical characteristics and salivary flow rate with machine learning | Scientific Reports
https://www.nature.com/articles/s41598-024-54120-x
Xerostomia may be accompanied by changes in salivary flow rate and the incidence increases in elderly. […] This study is the first to predict xerostomia with salivary flow rate in elderly based on artificial intelligence. […] The incidence of xerostomia increased with age. […] In patients more than 60 years of age, the UFR had a significantly higher predictive accuracy for xerostomia than the SFR. […] Xerostomia is a major concern and significantly reduces quality of life. […] The exact incidence of xerostomia is unknown, but it ranges from 0.9 to 64.8% in the general population and occurs in approximately 30% of adults over 65 years of age and 40% of adults over 80 years of age. […] The incidence of xerostomia is higher in the geriatric population than in younger adults. […] The causes of xerostomia in the older population have been attributed to local factors, such as poor dental health and infection of the mouth, as well as chronic systemic diseases or autoimmune diseases.
#50 Dry mouth and cancer | EBSCO Research Starters
https://www.ebsco.com/research-starters/health-and-medicine/dry-mouth-and-cancer
Approximately one-third to one-half of all cancer patients develop dry mouth complications because of radiation therapy, chemotherapy, and medication treatments. […] Patients with specific types of cancer, such as head and neck cancers, are between 90 and 100 percent likely to develop dry mouth. […] Dry mouth can be a temporary or permanent situation depending on its cause. Radiation therapy can permanently damage salivary glands, and chemotherapy can cause saliva to become thick. […] Serious oral infections and extensive decay may result in loss of teeth and difficulty wearing dentures. […] By avoiding the triggers that provoke dry mouth and using the recommended treatments, dry mouth may be manageable.
#51 Dry mouth and cancer | EBSCO Research Starters
https://www.ebsco.com/research-starters/health-and-medicine/dry-mouth-and-cancer
Approximately one-third to one-half of all cancer patients develop dry mouth complications because of radiation therapy, chemotherapy, and medication treatments. […] Patients with specific types of cancer, such as head and neck cancers, are between 90 and 100 percent likely to develop dry mouth. […] Dry mouth can be a temporary or permanent situation depending on its cause. Radiation therapy can permanently damage salivary glands, and chemotherapy can cause saliva to become thick. […] Serious oral infections and extensive decay may result in loss of teeth and difficulty wearing dentures. […] By avoiding the triggers that provoke dry mouth and using the recommended treatments, dry mouth may be manageable.
#52 Prediction of xerostomia in elderly based on clinical characteristics and salivary flow rate with machine learning | Scientific Reports
https://www.nature.com/articles/s41598-024-54120-x
Xerostomia can also seriously impact the quality of life and may alter speech, eating, and swallowing. […] The UFR, but not SFR, decreased with age significantly. […] The UFR had a significantly higher predictive accuracy for xerostomia than the SFR. […] The prediction accuracy of the multilayer perceptron (MLP) algorithm that combined UFR and SFR data was significantly better than either UFR or SFR individually. […] Significant predictors of xerostomia were obtained from logistic regression analysis, and the degree to which they contributed was estimated using weight=log odds ratio values. […] The main predictor of xerostomia was age. […] The risk of xerostomia increased with age. […] The prediction of xerostomia by the UFR was significant in patients aged over 60 years. […] The UFR contributes more significantly to the prediction of xerostomia than the SFR, and the weight of the UFR is higher in older people.
#53 Prediction of Dry Mouth Condition Using Radiomics Features from Tongue Diagnosis Image
https://www.mdpi.com/2076-3417/14/22/10118
The estimated linear equation was given by y = 0.9244x + 2.1664. […] Despite challenges such as issues with image focus, skewed data, and a limited dataset, the results demonstrated a high correlation (r = 0.9482) between the estimated salivary gland secretion and the tongue image features. […] Our findings will open up avenues for future research that harnesses the potential of tongue imaging in clinical practice.