Odra, świnka i różyczka
Zapobieganie i profilaktyka
Szczepionka MMR, zawierająca żywe atenuowane wirusy odry, świnki i różyczki, jest podawana podskórnie w schemacie dwóch dawek: pierwsza dawka między 12. a 15. miesiącem życia, druga między 4. a 6. rokiem życia. Skuteczność jednej dawki wynosi 93% przeciwko odrze, 72% przeciwko śwince i 97% przeciwko różyczce, natomiast po dwóch dawkach wzrasta do 97%, 86% i niemal 100% odpowiednio. Szczepionka jest zalecana również dla dorosłych bez udokumentowanego szczepienia lub przebytych chorób, szczególnie w grupach ryzyka, takich jak personel medyczny, studenci czy osoby podróżujące. Profilaktyka poekspozycyjna obejmuje podanie szczepionki w ciągu 72 godzin od kontaktu z chorym na odrę lub alternatywnie immunoglobuliny domięśniowo w dawce 0,5 ml/kg do 6 dni po ekspozycji.
- Szczepionka MMR (odra, świnka i różyczka) – charakterystyka
- Schematy szczepień przeciwko odrze, śwince i różyczce
- Szczepienia przeciwko odrze, śwince i różyczce w sytuacjach szczególnych
- Znaczenie szczepień MMR w zdrowiu publicznym
- Bezpieczeństwo i działania niepożądane szczepionki MMR
- Podsumowanie znaczenia profilaktyki poprzez szczepienie MMR
Szczepionka MMR (odra, świnka i różyczka) – charakterystyka
Szczepionka MMR (odra, świnka i różyczka) jest skojarzoną szczepionką zawierającą żywe atenuowane (osłabione) wirusy, która skutecznie zapobiega trzem poważnym chorobom zakaźnym: odrze, śwince i różyczce. Na rynku dostępne są preparaty takie jak M-M-R II firmy Merck oraz Priorix firmy GlaxoSmithKline Biologicals, które są w pełni wymienne w schemacie szczepień.12 Szczepionka MMR została wprowadzona w latach 70. XX wieku i od tego czasu znacząco przyczyniła się do redukcji zachorowań na wymienione choroby na całym świecie.3
Szczepionka jest podawana jako iniekcja podskórna, a jej skuteczność w zapobieganiu poszczególnym chorobom jest zróżnicowana. Jedna dawka szczepionki MMR jest skuteczna w 93% przeciwko odrze, 72% przeciwko śwince i 97% przeciwko różyczce. Po podaniu dwóch dawek skuteczność wzrasta do 97% przeciwko odrze, 86% przeciwko śwince i niemal 100% przeciwko różyczce.45 Dzięki powszechnemu stosowaniu tej szczepionki udało się znacząco zmniejszyć zachorowalność i śmiertelność spowodowaną przez te choroby, a w niektórych krajach nawet doprowadzić do ich eliminacji.6
Schematy szczepień przeciwko odrze, śwince i różyczce
Zgodnie z zaleceniami krajowych i międzynarodowych organizacji zdrowia, podstawowy schemat szczepienia przeciwko odrze, śwince i różyczce obejmuje podanie dwóch dawek szczepionki MMR. Pierwsza dawka powinna być podana dzieciom między 12. a 15. miesiącem życia, a druga dawka między 4. a 6. rokiem życia, przed rozpoczęciem nauki w szkole.78 Druga dawka nie jest dawką przypominającą, ale ma na celu wywołanie odporności u niewielkiego odsetka osób, które nie zareagowały na pierwszą dawkę.9
W przypadku niemowląt i dzieci podróżujących do obszarów o zwiększonym ryzyku zachorowania na odrę, zaleca się podanie dodatkowej dawki szczepionki już od 6. miesiąca życia. Dzieci, które otrzymały dawkę szczepionki przed ukończeniem pierwszego roku życia, powinny następnie otrzymać dwie standardowe dawki zgodnie z kalendarzem szczepień.1011 Warto podkreślić, że dawka podana przed ukończeniem pierwszego roku życia jest traktowana jako dawka dodatkowa i nie jest wliczana do standardowego schematu dwóch dawek.12
Szczepienia przeciwko odrze, śwince i różyczce u osób dorosłych
Osoby dorosłe urodzone po 1957 roku, które nie mają udokumentowanego przyjęcia szczepionki MMR lub przebytych chorób, powinny otrzymać co najmniej jedną dawkę szczepionki.13 Dwie dawki szczepionki MMR, w odstępie co najmniej 28 dni, zalecane są dla osób dorosłych z grup zwiększonego ryzyka, w tym:
- studentów szkół wyższych i policealnych
- pracowników ochrony zdrowia
- osób podróżujących za granicę
- osób z kontaktu domowego z osobami z obniżoną odpornością1415
Szczególną uwagę należy zwrócić na kobiety w wieku rozrodczym, które powinny być zaszczepione przeciwko różyczce ze względu na ryzyko wrodzonych wad rozwojowych u płodu w przypadku zakażenia różyczką podczas ciąży. Zaleca się, aby kobiety planujące ciążę były zaszczepione co najmniej 1 miesiąc przed poczęciem.1617
Szczepienia przeciwko odrze, śwince i różyczce w sytuacjach szczególnych
Profilaktyka poekspozycyjna
Szczepionka MMR może być stosowana jako profilaktyka poekspozycyjna u osób, które miały kontakt z chorym na odrę. Podanie szczepionki w ciągu 72 godzin od kontaktu z wirusem odry może zmniejszyć ryzyko zachorowania lub złagodzić przebieg choroby.1819 Jest to szczególnie ważne dla osób niezaszczepionych lub z niekompletnym schematem szczepień.
Profilaktykę poekspozycyjną zaleca się dla następujących grup:
- Niemowlęta w wieku 6-12 miesięcy, które są immunokompetentne i miały kontakt z chorym w ciągu ostatnich 72 godzin
- Osoby w wieku 12 miesięcy i starsze, które są immunokompetentne, niezaszczepione i miały kontakt z chorym w ciągu ostatnich 6 dni20
W przypadku gdy podanie szczepionki MMR w ciągu 72 godzin od ekspozycji nie jest możliwe, alternatywnym postępowaniem jest podanie immunoglobuliny (IG) domięśniowo w ciągu 6 dni od ekspozycji w dawce 0,5 ml/kg.2122
Szczepienia w czasie ognisk epidemicznych
W sytuacji wystąpienia ogniska epidemicznego odry, szczepionka MMR stanowi kluczowy element strategii zapobiegania rozprzestrzenianiu się choroby. W takich przypadkach zaleca się:
- Weryfikację statusu szczepień u osób z kontaktu z chorym
- Zaszczepienie osób bez udokumentowanej historii szczepień lub przebycia choroby
- Obniżenie wieku podania pierwszej dawki szczepionki do 6 miesięcy życia dla dzieci przebywających w ognisku epidemicznym2324
W przypadku ognisk epidemicznych świnki można rozważyć podanie trzeciej dawki szczepionki MMR osobom z grup zwiększonego ryzyka, które wcześniej otrzymały dwie dawki szczepionki.2526
Znaczenie szczepień MMR w zdrowiu publicznym
Powszechne stosowanie szczepionki MMR ma fundamentalne znaczenie dla zdrowia publicznego. Szczepienia przeciwko odrze, śwince i różyczce przyczyniły się do znaczącego spadku zachorowań na te choroby w wielu krajach, w tym w Stanach Zjednoczonych i Europie.27 Aby skutecznie zapobiegać wybuchom epidemii odry, konieczne jest utrzymanie wysokiego poziomu wyszczepialności populacji – co najmniej 95% osób powinno być zaszczepionych dwiema dawkami szczepionki MMR.28
Szczepienia MMR chronią nie tylko osoby zaszczepione, ale również osoby, które nie mogą zostać zaszczepione ze względów medycznych, takie jak niemowlęta poniżej 6. miesiąca życia, kobiety w ciąży czy osoby z ciężkimi niedoborami odporności. Jest to przykład tzw. odporności zbiorowiskowej, która zapewnia pośrednią ochronę osobom najbardziej narażonym na ciężki przebieg choroby.2930
Według Światowej Organizacji Zdrowia (WHO), w latach 2000-2023 szczepienia przeciwko odrze zapobiegły ponad 60 milionom zgonów na całym świecie.31 Pomimo tych sukcesów, w ostatnich latach obserwuje się wzrost liczby zachorowań na odrę w wielu krajach, co jest związane ze spadkiem wyszczepialności. W 2023 roku odnotowano 20% wzrost liczby przypadków odry na świecie w porównaniu do roku 2022.32
Przeciwwskazania i środki ostrożności przy szczepieniu MMR
Przeciwwskazania do szczepienia MMR obejmują:
- Ciężkie reakcje alergiczne na wcześniejszą dawkę szczepionki lub którykolwiek ze składników szczepionki
- Ciąża – ze względu na teoretyczne ryzyko dla płodu związane z żywymi atenuowanymi wirusami
- Ciężkie niedobory odporności3334
Osoby z łagodnymi chorobami, takimi jak przeziębienie, mogą być szczepione. Natomiast w przypadku umiarkowanej lub ciężkiej choroby z gorączką zaleca się odłożenie szczepienia do czasu ustąpienia objawów.35
W przypadku osób z rodzinnym wywiadem w kierunku wrodzonych lub dziedzicznych niedoborów odporności, szczepienie powinno być odroczone do czasu oceny statusu immunologicznego pacjenta.36
Bezpieczeństwo i działania niepożądane szczepionki MMR
Szczepionka MMR jest uznawana za bezpieczną i dobrze tolerowaną. Najczęstsze działania niepożądane po szczepieniu są zwykle łagodne i przejściowe, występują w ciągu pierwszych kilku dni po szczepieniu i obejmują:
- Ból i zaczerwienienie w miejscu podania
- Gorączkę
- Łagodną wysypkę
- Przejściowy ból i sztywność stawów3738
Rzadziej mogą wystąpić obrzęk węzłów chłonnych na policzkach lub szyi. Poważne działania niepożądane, takie jak ciężkie reakcje alergiczne, zdarzają się niezwykle rzadko – szacunkowo u mniej niż 1 na milion zaszczepionych osób.39
Warto podkreślić, że w wyniku licznych badań naukowych obalono teorię o związku szczepionki MMR z autyzmem. Nie istnieją żadne wiarygodne dowody naukowe potwierdzające taką zależność.4041
Podsumowanie znaczenia profilaktyki poprzez szczepienie MMR
Szczepionka MMR stanowi kluczowy element profilaktyki trzech poważnych chorób zakaźnych: odry, świnki i różyczki. Dwie dawki szczepionki zapewniają długotrwałą ochronę przed tymi chorobami i ich potencjalnymi powikłaniami. Dzięki wysokiej skuteczności i bezpieczeństwu, szczepionka MMR przyczyniła się do znaczącego spadku zachorowalności i śmiertelności związanej z tymi chorobami na całym świecie.4243
Warto podkreślić, że szczepienie przeciwko odrze, śwince i różyczce ma wymiar nie tylko indywidualny, ale także społeczny. Wysoki poziom wyszczepialności populacji (powyżej 95%) zapewnia odporność zbiorowiskową, chroniąc osoby, które nie mogą być zaszczepione z powodów medycznych.44
W obliczu rosnącej liczby zachorowań na odrę w wielu krajach, utrzymanie wysokiego poziomu wyszczepialności przeciwko odrze, śwince i różyczce pozostaje priorytetem dla zdrowia publicznego. Zapewnienie powszechnego dostępu do szczepionki MMR oraz edukacja społeczeństwa na temat jej bezpieczeństwa i skuteczności są kluczowymi elementami strategii zapobiegania tym chorobom.4546
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Materiały źródłowe
- #1https://www.healio.com/clinical-guidance/measles/measles-vaccines-prevention-and-control-guidelines
Two measles, mumps, and rubella (MMR) vaccines are licensed in the US: M-M-R II (Merck Co) and PRIORIX (GlaxoSmithKline Biologicals); these two vaccines are fully interchangeable in the schedule. […] The efficacy of a single dose of a live attenuated measles vaccine is estimated at 77% when administered at 9-11 months of age and 92% when administered at 12 months of age. Two doses of the vaccine increase vaccine efficacy to 94%. […] According to the CDC/ACIP, all children should be immunized against measles, with the first dose administered at 12-15 months, followed by a second dose at 4-6 years of age. […] The CDC/ACIP recommends that adults born in 1957 or later who do not have evidence of immunity to measles (or mumps or rubella) should receive, at a minimum, one dose of an MMR vaccine. […] Adults of all ages without evidence of immunity to measles who are considered to be at potentially increased risk of exposure to measles should receive two doses of an MMR vaccine.
- #2https://content.govdelivery.com/accounts/MIOAKL/bulletins/33950a6
Since 1978, M-M-R II has been the only measles, mumps, and rubella (MMR) combination vaccine used in the United States. […] On June 23, 2022, the Advisory Committee on Immunization Practices (ACIP) recommended PRIORIX as an additional option to prevent measles, mumps, and rubella (MMR) according to existing vaccine recommendations and off-label uses. […] Either vaccine may be administered in any situation in which an MMR viruscontaining vaccine is indicated. […] For routine vaccination, 2 doses are recommended, the first at age 12-15 months, and the second at age 4-6 years. […] Before international travel, infants aged 6-11 months should receive a single dose. Travelers aged 12 months who have not received 2 doses of MMR should receive 2 doses separated by 28 days.
- #3https://pmc.ncbi.nlm.nih.gov/articles/PMC8903938/
Measles, mumps, and rubella are highly contagious diseases that caused significant global mortality and morbidity in the pre-vaccine era. Since its first approval in the United States over 40 years ago, M-M-RII has been used in 75 countries for prevention of these diseases. […] This report summarizes the efficacy, effectiveness, immunogenicity, and safety of M-M-RII, over more than 40 years since its first approval in the United States. […] Prevention of measles, mumps, and rubella continues to be an important public health initiative and M-M-RII plays an important role in the prevention of these diseases. […] These studies confirm that routine use of M-M-RII provides effective protection during outbreaks, and that the vaccine is also an effective public health tool in preventing measles post-exposure. Administration of a third dose of M-M-RII may be useful in certain situations, as recommended by the US Advisory Committee on Immunization Practices. […] M-M-RII has been used globally for over 40 years, has helped substantially reduce morbidity and mortality from measles, mumps, rubella, and congenital rubella syndrome, and has contributed to the elimination of these diseases in several countries.
- #4 Measles Vaccination | Measles (Rubeola) | CDChttps://www.cdc.gov/measles/vaccines/index.html
MMR vaccine prevents your child from getting a rash and fever from rubella. […] MMR vaccination is important for children as well as adults who do not have evidence of immunity. […] MMR vaccine is very safe and is effective at preventing measles, mumps, and rubella. […] One dose of MMR vaccine is 93% effective against measles, 72% effective against mumps, and 97% effective against rubella. […] Two doses of MMR vaccine are 97% effective against measles and 86% effective against mumps. […] The MMR vaccine is safe. There’s no harm in getting another dose if you may already be immune to measles, mumps, or rubella. […] The best protection against measles is the MMR vaccine.
- #5 Measles, Mumps and Rubella – Institute for Vaccine Safetyhttps://www.vaccinesafety.edu/measles-mumps-and-rubella/
Persons previously vaccinated with two doses of a mumps-containing vaccine who are identified by public health as at increased risk for mumps because of an outbreak should receive a third dose of a mumps-containing vaccine to improve protection against mumps disease and related complications. […] Measles, mumps and rubella vaccines are all live attenuated viral vaccines that are only available in combination as MMR in the United States. […] One dose of MMR vaccine is estimated to be 93% effective in preventing measles and 97% effective in preventing rubella. A second dose has been shown to increase the effectiveness of measles vaccine to an estimated 97%, mainly by producing immunity in those who failed to respond to the initial dose. […] Effectiveness of two doses of MMR vaccine against mumps is estimated to be between 66 and 95%, and vaccine-induced protection has been shown to wane over time.
- #6https://pmc.ncbi.nlm.nih.gov/articles/PMC8903938/
Measles, mumps, and rubella are highly contagious diseases that caused significant global mortality and morbidity in the pre-vaccine era. Since its first approval in the United States over 40 years ago, M-M-RII has been used in 75 countries for prevention of these diseases. […] This report summarizes the efficacy, effectiveness, immunogenicity, and safety of M-M-RII, over more than 40 years since its first approval in the United States. […] Prevention of measles, mumps, and rubella continues to be an important public health initiative and M-M-RII plays an important role in the prevention of these diseases. […] These studies confirm that routine use of M-M-RII provides effective protection during outbreaks, and that the vaccine is also an effective public health tool in preventing measles post-exposure. Administration of a third dose of M-M-RII may be useful in certain situations, as recommended by the US Advisory Committee on Immunization Practices. […] M-M-RII has been used globally for over 40 years, has helped substantially reduce morbidity and mortality from measles, mumps, rubella, and congenital rubella syndrome, and has contributed to the elimination of these diseases in several countries.
- #7 Measles Vaccination | Measles (Rubeola) | CDChttps://www.cdc.gov/measles/vaccines/index.html
Two doses of the MMR vaccine are recommended by doctors as the best way to protect against measles, mumps, and rubella. […] The best way to protect against measles is to get the measles, mumps, and rubella (MMR) vaccine. […] Most people who are vaccinated with MMR MMRV will be protected for life. […] Both MMR and MMRV vaccines may be given at the same time as other vaccines. […] Children need 2 doses of MMR vaccines: 1215 months old 1st dose 46 years old 2nd dose. […] Anyone traveling internationally should be fully vaccinated before traveling. […] The MMR vaccine protects your child from measles, mumps, and rubella, potentially serious diseases caused by viruses. […] MMR vaccine protects your child from getting an uncomfortable rash and high fever from measles. […] MMR vaccine protects your child from getting a fever and swollen glands under the ears or jaw from mumps.
- #8 M-M-R®II (Measles, Mumps, and Rubella Virus Vaccine Live) | Official Sitehttps://www.merckvaccines.com/mmr/
M-M-RII is a vaccine indicated for active immunization for the prevention of measles, mumps, and rubella in individuals 12 months of age or older. […] The first dose of M-M-RII is administered at 12 to 15 months of age and the second dose of M-M-RII is administered at 4 to 6 years of age. […] M-M-RII is a vaccine indicated for active immunization for the prevention of measles, mumps, and rubella in individuals 12 months of age or older. […] The first dose of M-M-RII is administered at 12 to 15 months of age and the second dose of M-M-RII is administered at 4 to 6 years of age.
- #9 Ask The Experts About Vaccines: MMR (Measles, Mumps, and Rubella) | Immunize.orghttps://www.immunize.org/ask-experts/topic/mmr/
MMR can be given to children as young as 6 months of age who are at high risk of exposure such as during international travel or a community outbreak. […] MMR vaccine is recommended for all children at age 12 through 15 months, with a second dose at age 4 through 6 years. […] The second dose is not a booster, but rather is intended to produce immunity in the small number of people who fail to respond to the first dose. […] The second dose of MMR may be given as early as 4 weeks after the first dose, and be counted as a valid dose, if both doses were given after the first birthday.
- #10https://www.healthychildren.org/English/safety-prevention/immunizations/Pages/Protecting-Your-Baby-from-a-Measles-Outbreak-FAQs.aspx
The recommended age for the first dose of measles, mumps and rubella (MMR) vaccine is 12 to 15 months of age. […] If you live in or plan to travel to a community experiencing an outbreak, or if you travel internationally, your baby may be vaccinated as early as 6 months of age. […] Babies who get one dose of MMR vaccine before their first birthday should get two more doses (one dose at 12 through 15 months of age and another dose at least 28 days later). […] While the main symptoms of measles are bad enough, the reason we vaccinate against measles is to prevent the complications associated with it such as pneumonia and encephalitis (an infection of the brain). […] The MMR vaccine is a live vaccine, which means it contains weakened forms of the viruses. In order to work, those weakened forms of the virus need to multiply to create an immune response.
- #11 The Medical Letter Home Page | The Medical Letter, Inc.https://secure.medicalletter.org/TML-article-5107a
According to the Centers for Disease Control (CDC), as of April 24 there have been 844 confirmed cases of measles in the US in 2025; 11% of cases have resulted in hospitalization and 3 patients have died. The majority of cases (96%) have been in unvaccinated persons or in those whose vaccination history was unknown. […] The live-attenuated MMR (measles, mumps, rubella) vaccine [or the MMRV (measles, mumps, rubella, varicella) vaccine in children 12 months-12 years old], offers the best protection against measles; one dose is 93% and two doses are 97% effective in preventing infection. […] The Advisory Committee on Immunization Practices (ACIP) currently recommends 2 lifetime doses of an MMR vaccine for most individuals; the first dose should be given at 12-15 months of age and the second at 4-6 years (3 months after first dose is an alternative). Infants 6-11 months old who will be traveling internationally should receive one early dose of MMR vaccine before travel followed by the routine 2-dose series after their first birthday.
- #12https://www.nbcnews.com/health/kids-health/measles-vaccine-can-young-children-get-early-dose-mmr-shot-rcna198038
Vaccination is the best way to protect against infection, but the first dose of the measles-mumps-rubella (MMR) vaccine usually isnt given until a child is 12 to 15 months old. A second dose is given from ages 4 to 6. […] Both the Centers for Disease Control and Prevention and the American Academy of Pediatrics say that, in the case of an outbreak or international travel, children as young as 6 months can get a dose of the vaccine, and children under 4 years old who have gotten one dose can get their second one earlier. All doses must be separated by at least four weeks. […] Dr. Shilpa Patel, a pediatrician at New Jersey Hackensack Meridian Health Medical Group Northern Valley Pediatrics, said that an early dose before 12 months is essentially a bonus dose, and doesnt take the place of either of the two standard doses.
- #13 M-M-R II, Priorix (measles mumps and rubella vaccine, live) dosing, indications, interactions, adverse effects, and morehttps://reference.medscape.com/drug/mmrii-priorix-measles-mumps-and-rubella-vaccine-live-343159
Adults born before 1957 are considered immune to measles and mumps; all adults born in 1957 or later should have documentation of 1 or more doses of MMR vaccine unless contraindicated, or laboratory evidence of immunity to each of the 3 diseases […] Pregnant women who do not have evidence of immunity should receive MMR vaccine upon completion or termination of pregnancy and before discharge from the health-care facility […] Safety and efficacy for postexposure prophylaxis have not been established […] Vaccination should be deferred in individuals with a family history of congenital or hereditary immunodeficiency until the individuals immune status has been evaluated and the individual has been found to be immunocompetent.
- #14 The Medical Letter Home Page | The Medical Letter, Inc.https://secure.medicalletter.org/TML-article-5107a
Due to current outbreaks in the US, some experts are recommending that infants 6-11 months old who live in or are traveling to an area in the US where an outbreak is occurring also receive an early dose. […] Two doses of the vaccine, separated by at least 28 days, are recommended for adults without evidence of immunity who are at high risk of exposure to or transmission of measles or mumps, including students in postsecondary educational institutions, international travelers, and household contacts of immunocompromised persons. […] Because MMR is a live vaccine, it is contraindicated for use in pregnant women and in adults with severe immunodeficiency. […] Pain and erythema at the injection site, fever, rash, and transient arthralgia are common following MMR vaccination.
- #15 Prevention of Measles, Rubella, Congenital Rubella Syndrome, and Mumps, 2013: Summary Recommendations of the Advisory Committee on Immunization Practices (ACIP) – Healthy People 2030 | odphp.health.govhttps://odphp.health.gov/healthypeople/tools-action/browse-evidence-based-resources/prevention-measles-rubella-congenital-rubella-syndrome-and-mumps-2013-summary-recommendations-advisory-committee-immunization-practices-acip
The best way to protect against these diseases is to get a measles, mumps, and rubella (MMR) vaccine. […] ACIP recommends the following MMR vaccination schedule to prevent measles and mumps: 2 doses routinely for children, with the first dose given at age 12 through 15 months and the second dose given at age 4 through 6 years (before starting school) […] 1 dose for adults age 18 years and older […] 2 doses are recommended for adults at high risk for exposure and transmission (e.g., students attending colleges or other post-high school educational institutions, health care personnel, international travelers) […] To prevent rubella, ACIP recommends 1 dose of MMR vaccine for people age 12 months and older. […] The report also includes further details on vaccine safety, efficacy, and contraindications. For example, the MMR vaccine is not recommended for pregnant people or people with immunodeficiency.
- #16 MMR Vaccine – StatPearls – NCBI Bookshelfhttps://www.ncbi.nlm.nih.gov/books/NBK554450/
Vaccinating women before or during reproductive years is also important, as rubella can cause congenital malformations in the fetus. Recommendations for unvaccinated female patients planning pregnancy include vaccination with the MMR vaccine at least 1 month before conception. […] The MMR vaccine should be administered after delivery to individuals who are not immunized, as the MMR vaccine is safe during breastfeeding. […] The administration of the MMR vaccine is appropriate for specific patient populations as post-exposure prophylaxis. Patient populations given the MMR vaccine as post-exposure prophylaxis include infants aged between 6 and 12 months who are immunocompetent and have been exposed in the last 72 hours, and non-pregnant patients 12 months or older who are immunocompetent with exposure in the previous 6 days.
- #17 Measles, Mumps and Rubella – Institute for Vaccine Safetyhttps://www.vaccinesafety.edu/measles-mumps-and-rubella/
Vaccination against rubella is emphasized for all non-pregnant individuals of childbearing age, especially those born outside of the United States. Rubella immunity should be verified by their health care providers either by documentation of at least one dose of rubella-containing vaccine given after the first year of life or by serology. Those without such evidence of immunity should be given MMR vaccine, excluding women who are pregnant or currently attempting to become pregnant (pregnancy should be avoided for at least 4 weeks following MMR vaccination).
- #18 Ask The Experts About Vaccines: MMR (Measles, Mumps, and Rubella) | Immunize.orghttps://www.immunize.org/ask-experts/topic/mmr/
MMR vaccine is recommended routinely for all children at age 12 through 15 months, with a second dose at age 4 through 6 years. […] Adults with no evidence of immunity should get 1 dose of MMR vaccine. […] During an outbreak of measles, healthcare facilities should recommend 2 doses of MMR vaccine at the appropriate interval for unvaccinated healthcare personnel regardless of birth year if they lack laboratory evidence of measles immunity. […] MMR vaccine given within 72 hours of initial measles exposure can reduce the risk of getting sick or reduce the severity of symptoms. […] Postexposure prophylaxis with MMR vaccine does not prevent or alter the clinical severity of mumps or rubella. […] Measles vaccine, given as MMR, may be effective if given within the first 3 days (72 hours) after exposure to measles.
- #19 MMR Vaccine – StatPearls – NCBI Bookshelfhttps://www.ncbi.nlm.nih.gov/books/NBK554450/
Vaccinating women before or during reproductive years is also important, as rubella can cause congenital malformations in the fetus. Recommendations for unvaccinated female patients planning pregnancy include vaccination with the MMR vaccine at least 1 month before conception. […] The MMR vaccine should be administered after delivery to individuals who are not immunized, as the MMR vaccine is safe during breastfeeding. […] The administration of the MMR vaccine is appropriate for specific patient populations as post-exposure prophylaxis. Patient populations given the MMR vaccine as post-exposure prophylaxis include infants aged between 6 and 12 months who are immunocompetent and have been exposed in the last 72 hours, and non-pregnant patients 12 months or older who are immunocompetent with exposure in the previous 6 days.
- #20 MMR Vaccine – StatPearls – NCBI Bookshelfhttps://www.ncbi.nlm.nih.gov/books/NBK554450/
Vaccinating women before or during reproductive years is also important, as rubella can cause congenital malformations in the fetus. Recommendations for unvaccinated female patients planning pregnancy include vaccination with the MMR vaccine at least 1 month before conception. […] The MMR vaccine should be administered after delivery to individuals who are not immunized, as the MMR vaccine is safe during breastfeeding. […] The administration of the MMR vaccine is appropriate for specific patient populations as post-exposure prophylaxis. Patient populations given the MMR vaccine as post-exposure prophylaxis include infants aged between 6 and 12 months who are immunocompetent and have been exposed in the last 72 hours, and non-pregnant patients 12 months or older who are immunocompetent with exposure in the previous 6 days.
- #21 MMR Vaccine – StatPearls – NCBI Bookshelfhttps://www.ncbi.nlm.nih.gov/books/NBK554450/
Vaccination remains the most effective prevention strategy. Children should receive 2 doses of MMR at 12 to 15 months and 4 to 6 years. […] Non-immune exposed individuals should be excluded from work and evaluated for post-exposure prophylaxis (PEP), which includes either the MMR vaccine within 72 hours of exposure or intramuscular immunoglobulin (IG) within 6 days at a dose of 0.5 mL/kg.
- #22 LAC | DPH – Vaccine Preventable Disease Control Programhttp://publichealth.lacounty.gov/ip/diseases/measles/index.htm
- #23 Measles vaccines: Canadian immunization guide – Canada.cahttps://www.canada.ca/en/public-health/services/publications/healthy-living/canadian-immunization-guide-part-4-active-vaccines/page-12-measles-vaccine.html
The goal of measles post-exposure prophylaxis (PEP) is to prevent severe disease, including hospitalization, as well as to prevent mortality. […] Administration of measles PEP as soon as possible following measles exposure is recommended and should be offered to individuals not expected to be immune to measles. […] Prophylactic use of MMR vaccine has been shown to be effective if provided within 72 hours of exposure while the prophylactic use of human immunoglobulin (Ig) has been shown to be effective in modifying or preventing disease if administered within 6 days after exposure to measles. […] Immunization with measles-containing vaccine is an integral element of a comprehensive measles outbreak prevention and management strategy. […] In a measles outbreak, susceptible individuals 6 months of age and older may receive MMR vaccine.
- #24 With lower measles vaccine rates, some North Dakota counties may struggle with virus, experts say – InForum | Fargo, Moorhead and West Fargo news, weather and sportshttps://www.inforum.com/news/north-dakota/with-lower-measles-vaccine-rates-some-north-dakota-counties-may-struggle-with-virus-experts-say
FARGO â As fewer people in North Dakota vaccinate their children for measles, some counties, particularly in the west, may struggle with the contagious and fatal disease, health experts say. […] Public health officials recommend that 95% of the population be vaccinated to prevent widespread infection. North Dakotaâs rate is less than 90%, according to state data. […] The U.S. Centers for Disease Control and Prevention recommends children get two shots of the MMR vaccine â first between the ages of 12 and 15 months, then again between 4 and 6 years old. One dose is 93% effective against measles, and two is 97%, the CDC said. […] The vaccine typically protects a person for life, the CDC said. […] The MMR vaccine is the most effective way to fight measles and is safe, Carson said. The state is recommending children as young as 6 months old get the vaccine if they live in or travel to Williams County, Howell said. The second dose can be administered 28 days later, she said.
- #25 Measles, Mumps and Rubella – Institute for Vaccine Safetyhttps://www.vaccinesafety.edu/measles-mumps-and-rubella/
Persons previously vaccinated with two doses of a mumps-containing vaccine who are identified by public health as at increased risk for mumps because of an outbreak should receive a third dose of a mumps-containing vaccine to improve protection against mumps disease and related complications. […] Measles, mumps and rubella vaccines are all live attenuated viral vaccines that are only available in combination as MMR in the United States. […] One dose of MMR vaccine is estimated to be 93% effective in preventing measles and 97% effective in preventing rubella. A second dose has been shown to increase the effectiveness of measles vaccine to an estimated 97%, mainly by producing immunity in those who failed to respond to the initial dose. […] Effectiveness of two doses of MMR vaccine against mumps is estimated to be between 66 and 95%, and vaccine-induced protection has been shown to wane over time.
- #26 Mumps vaccines: Canadian Immunization Guide – Canada.cahttps://www.canada.ca/en/public-health/services/publications/healthy-living/canadian-immunization-guide-part-4-active-vaccines/page-14-mumps-vaccine.html
In an outbreak setting, implementation of an outbreak dose of MMR vaccine may be considered as a part of the broader outbreak management strategy. […] The public health response to mumps includes management of cases and contacts and identifying social networks to define the at-risk population when contact follow-up is not feasible; and maintaining/enhancing surveillance for further cases and disease outcomes (e.g., hospitalizations, complications). […] Vaccination of under-immunized groups. […] For a list of considerations for Mumps Outbreak Management options please see NACI statement on the Use of Measles-Mumps-Rubella (MMR) Vaccine for the Management of Mumps Outbreaks in Canada.
- #27 MMR vaccine – Wikipediahttps://en.wikipedia.org/wiki/MMR_vaccine
The MMR vaccine is a vaccine against measles, mumps, and rubella (German measles), abbreviated as MMR. The first dose is generally given to children around 9 months to 15 months of age, with a second dose at 15 months to 6 years of age, with at least four weeks between the doses. After two doses, 97% of people are protected against measles, 88% against mumps, and at least 97% against rubella. The vaccine is also recommended for those who do not have evidence of immunity, those with well-controlled HIV/AIDS, and within 72 hours of exposure to measles among those who are incompletely immunized. It is given by injection. […] The MMR vaccine is widely used around the world. As of 2012, 575 million doses had been administered since the vaccine’s introduction worldwide. Measles resulted in 2.6 million deaths per year before immunization became common. This has decreased to 122,000 deaths per year as of 2012, mostly in low-income countries. Through vaccination, as of 2018, rates of measles in North and South America are very low. Rates of disease have been seen to increase in populations that go unvaccinated. Between 2000 and 2018, vaccination decreased measles deaths by 73%.
- #28 LAC | DPH – Vaccine Preventable Disease Control Programhttp://publichealth.lacounty.gov/ip/diseases/measles/index.htm
Vaccination is the most effective way to prevent measles. […] Measles can be prevented by the measles-mumps-rubella (MMR) vaccine. […]
- #29 MMR (measles, mumps and rubella) vaccine – NHShttps://www.nhs.uk/vaccinations/mmr-vaccine/
The MMR vaccine gives long-term protection against measles, mumps and rubella. […] 2 doses of the MMR vaccine gives you long-term protection. […] Getting vaccinated also helps protect people who cannot be vaccinated, such as unborn babies, newborn babies and anyone with a weakened immune system. […] The MMR vaccine is recommended for all babies and young children, but older children and adults can have it if they were not vaccinated when they were younger. […] Speak to a GP about getting vaccinated if you did not have it as a child, you only had 1 dose or you’re not sure if you’ve been fully vaccinated. […] It’s especially important to make sure you’re vaccinated if: you’re a child, teenager or young adult; you could become pregnant; you’re travelling to, or living in, a country where there is a higher risk of getting measles, mumps or rubella; you’re a healthcare worker; you were born between 1970 and 1990 (as you may not have been vaccinated against all 3 infections).
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- #31https://www.who.int/news-room/spotlight/history-of-vaccination/history-of-measles-vaccination
In 1971 Hilleman combined the recently developed vaccines against measles, mumps and rubella into the MMR vaccine, administered as a single shot, with one booster dose following and in 2005, the varicella vaccine was added, to make the combined MMRV vaccine. […] Widespread childhood vaccination against measles has drastically reduced disease rates worldwide. WHO now recommends vaccination at 9 months for babies in areas where measles is common, and at 12-15 months for those in other areas. […] A second dose is recommended for all children, essential to protect the approximately 15% of children who donât develop protective immunity after their first dose. […] To address these issues, the Pan American Health Organization (PAHO, the WHO Regional Office for the Americas), has trained countries in rapid response to avoid measles and rubella virus spreading, improved surveillance, and launched renewed high-quality follow up vaccination campaigns. […] Between 2000 and 2023, measles vaccination prevented more than 60 million deaths worldwide.
- #32 What you should know about measles and how the MMR vaccine can protect your familymenu iconsearch iconsubscribe iconsearch iconarrow up right iconhttps://health.ucdavis.edu/blog/cultivating-health/what-you-should-know-about-measles-and-how-the-mmr-vaccine-can-protect-your-family/2024/11
Measles cases are on the rise globally. From 2022 to 2023, there was a 20% increase in cases, according to the World Health Organization and the U.S. Centers for Disease Control and Prevention (CDC). […] Two doses of the measles vaccine can prevent measles. However, more than 22 million children worldwide didn’t get their first dose of the measles vaccine in 2023, according to the CDC. […] The measles, mumps, and rubella (MMR) vaccine provides the best protection from measles. The MMR vaccine provides lasting protection against all strains of measles. […] High rates of MMR vaccinations in the U.S. have made measles, mumps and rubella far less common among Americans. […] The MMR vaccine is given in two doses. The first dose is typically given to babies ages 12-15 months. The second dose is given between ages 4 and 6 years old. The MMR vaccine can safely be given with other vaccines. […] Most people are protected from measles, mumps and rubella for life. […] The MMR vaccine is considered safe and effective. It provides the most effective prevention against measles, mumps and rubella. Most children have very minor side effects and no long term effects after getting the vaccine.
- #33 The Medical Letter Home Page | The Medical Letter, Inc.https://secure.medicalletter.org/TML-article-5107a
Due to current outbreaks in the US, some experts are recommending that infants 6-11 months old who live in or are traveling to an area in the US where an outbreak is occurring also receive an early dose. […] Two doses of the vaccine, separated by at least 28 days, are recommended for adults without evidence of immunity who are at high risk of exposure to or transmission of measles or mumps, including students in postsecondary educational institutions, international travelers, and household contacts of immunocompromised persons. […] Because MMR is a live vaccine, it is contraindicated for use in pregnant women and in adults with severe immunodeficiency. […] Pain and erythema at the injection site, fever, rash, and transient arthralgia are common following MMR vaccination.
- #34 Measles, Mumps, and Rubella Vaccine – Infections – Merck Manual Consumer Versionhttps://www.merckmanuals.com/home/infections/immunization/measles-mumps-and-rubella-vaccine
Adults who are likely to be exposed to these infections should get a second dose of the vaccine. […] A second dose of the MMR vaccine should also be given to people who live in the same house as a person with a severely weakened immune system. […] Pregnant women and people who are have had serious allergic reactions to gelatin or to certain antibiotics (particularly neomycin) should not be given this vaccine. […] Certain other conditions may affect whether and when people are vaccinated. […] If people have a temporary illness, doctors usually wait to give the vaccine until the illness resolves.
- #35 MMR (measles, mumps, and rubella) vaccine – what you need to know Information | Mount Sinai – New Yorkhttps://www.mountsinai.org/health-library/special-topic/mmr-measles-mumps-and-rubella-vaccine-what-you-need-to-know
MMR vaccine may be given at the same time as other vaccines. […] People with minor illnesses, such as a cold, may be vaccinated. People who are moderately or severely ill should usually wait until they recover before getting MMR vaccine. […] Adverse reactions should be reported to the Vaccine Adverse Event Reporting System (VAERS).
- #36 M-M-R II, Priorix (measles mumps and rubella vaccine, live) dosing, indications, interactions, adverse effects, and morehttps://reference.medscape.com/drug/mmrii-priorix-measles-mumps-and-rubella-vaccine-live-343159
Adults born before 1957 are considered immune to measles and mumps; all adults born in 1957 or later should have documentation of 1 or more doses of MMR vaccine unless contraindicated, or laboratory evidence of immunity to each of the 3 diseases […] Pregnant women who do not have evidence of immunity should receive MMR vaccine upon completion or termination of pregnancy and before discharge from the health-care facility […] Safety and efficacy for postexposure prophylaxis have not been established […] Vaccination should be deferred in individuals with a family history of congenital or hereditary immunodeficiency until the individuals immune status has been evaluated and the individual has been found to be immunocompetent.
- #37 Measles, Mumps, and Rubella (MMR) | Washington State Department of Healthhttps://doh.wa.gov/you-and-your-family/immunization/diseases-and-vaccines/measles-mumps-and-rubella-mmr
Measles is incredibly contagious. The best protection against measles is the measles, mumps, and rubella (MMR) vaccine. MMR vaccine provides long-lasting protection against all strains of measles. […] The best way to protect from mumps is to get vaccinated with the MMR vaccine. Vaccination prevents most cases and complications from mumps. […] This is why MMR vaccination is the most effective way to prevent rubella infection. […] Children should receive 2 doses of MMR vaccine. […] The most common side effects of MMR vaccine include: Sore arm or redness where the vaccine is given, Fever, Mild rash, Temporary pain and stiffness in the joints. […] Getting two doses of the MMR vaccine is 97% effective at preventing measles and rubella, and 88% effective against mumps. Vaccinated people who do get sick from the disease have milder symptoms. […] MMR vaccine is required for child care and school entry in the state of Washington.
- #38 Measles, mumps, rubella, varicella (chickenpox) â immunisation | Better Health Channelhttps://www.betterhealth.vic.gov.au/health/healthyliving/measles-mumps-rubella-varicella-chickenpox-immunisation
Immunisation is the best protection against measles, mumps, rubella and varicella (commonly known as chickenpox). […] Immunisation against measles, mumps and rubella can be provided with the MMR combination vaccine. […] Immunisation with MMRV vaccine at 18 months gives very young children early protection against measles, mumps, rubella and chickenpox. […] Protection against measles, mumps, rubella and chickenpox is available under the National Immunisation Program (NIP) Schedule. […] The combined MMR and MMRV vaccines are effective and safe, but all medications can have unwanted side effects. […] Common side effects following immunisation are usually mild and temporary (occurring in the first few days after vaccination). Specific treatment is not usually required. […] The MMRV vaccine can cause a mild chickenpox-like rash 5 to 26 days after vaccination.
- #39 MMR Vaccine (Measles, Mumps, and Rubella): MedlinePlus Drug InformationLockhttps://medlineplus.gov/druginfo/meds/a601176.html
In some cases, your health care provider may decide to postpone MMR vaccination until a future visit. […] People with minor illnesses, such as a cold, may be vaccinated. […] As with any medicine, there is a very remote chance of a vaccine causing a serious a severe allergic reaction, injury, or death.
- #40 Measles Vaccine | AAFPhttps://www.aafp.org/family-physician/patient-care/prevention-wellness/immunizations-vaccines/disease-pop-immunization/measles-vaccine.html
Reassure your patients that getting the MMR vaccine is much safer than getting measles. […] If parents are concerned about an association between MMR vaccination and autism, reassure them that the claim that the MMR vaccine causes autism is a myth and is not true. […] More than 95% of individuals who receive a single dose of MMR will develop immunity to all three viruses (measles, mumps, and rubella). A second dose provides immunity to almost all individuals who did not respond to the first dose. […] Administering the MMR vaccine helps protect members of the community who are not eligible for the vaccine such as infants or immunocompromised individuals, because the spread of contagious disease is contained.
- #41 What to Know About Measles and Vaccines | Johns Hopkins | Bloomberg School of Public Healthhttps://publichealth.jhu.edu/2025/what-to-know-about-measles-and-vaccines
No, the MMR vaccine protects has been exhaustively studied and proven safe. […] No. Numerous epidemiological studies have found no association between the MMR vaccine and autism. […] After receiving the MMR vaccine, your body takes time to create antibodies, which is what provides you protection if you are exposed to the virus in the future. […] Most but not all people vaccinated against measles are protected for life, and the chance of being protected increases with a second dose of measles vaccine. […] Your best bet is to check your vaccination records. […] No. Measles is a dangerous disease and the vaccine is very safe. […] You can get measles vaccinations at doctors offices, clinics, and government health centers. […] The CDC website is a good resource for keeping track of national trends and outbreaks.
- #42 Measles Vaccination | Measles (Rubeola) | CDChttps://www.cdc.gov/measles/vaccines/index.html
MMR vaccine prevents your child from getting a rash and fever from rubella. […] MMR vaccination is important for children as well as adults who do not have evidence of immunity. […] MMR vaccine is very safe and is effective at preventing measles, mumps, and rubella. […] One dose of MMR vaccine is 93% effective against measles, 72% effective against mumps, and 97% effective against rubella. […] Two doses of MMR vaccine are 97% effective against measles and 86% effective against mumps. […] The MMR vaccine is safe. There’s no harm in getting another dose if you may already be immune to measles, mumps, or rubella. […] The best protection against measles is the MMR vaccine.
- #43 MMR Vaccine (Measles, Mumps & Rubella Vaccination)https://my.clevelandclinic.org/health/procedures/mmr-vaccine
The MMR vaccine is highly effective at protecting you and your child against three serious viral infections: measles, mumps and rubella. […] The MMR vaccine can help prevent measles, mumps and rubella. These viral infections are all highly infectious conditions that can spread easily among people who arent vaccinated. […] The CDC recommends that children should receive two doses of the MMR vaccine. They should receive their first dose between 12 and 15 months old. They typically receive their second dose between 4 and 6 years old. […] The MMR vaccine reduces your risk of getting measles, mumps and rubella. These are all highly contagious viral infections that can cause serious, life-threatening health conditions. […] The MMR vaccine can provide strong protection against measles, mumps and rubella and the complications caused by these diseases.
- #44 How dangerous is a measles outbreak? – UChicago Medicinehttps://www.uchicagomedicine.org/forefront/pediatrics-articles/2025/march/measles-is-still-a-very-dangerous-disease
Measles is a very contagious and dangerous disease but its also preventable. […] Thanks to a coordinated and highly effective effort to deliver the measles, mumps and rubella (MMR) vaccine, it was declared eliminated from the U.S. in 2000. […] More than 97% of people who receive two doses of the MMR vaccine develop immunity to measles. […] Children should be vaccinated after their first birthday and receive an additional dose of MMR vaccine before entering kindergarten (when theyre 4 to 6 years old). […] Adults who do not meet these criteria should be vaccinated with at least one dose of the MMR vaccine unless their physician recommends against it due to special circumstances, such as severely compromised immunity. […] Fortunately, for most people, measles is not life-threatening but the problem is that you can’t predict who will become seriously ill. […] The only way to prevent measles is with the MMR vaccine. […] Everyone has a responsibility to take precautions to avoid the virus and to ensure their vaccinations are up-to-date to protect themselves and their neighbors.
- #45 What you should know about measles and how the MMR vaccine can protect your familymenu iconsearch iconsubscribe iconsearch iconarrow up right iconhttps://health.ucdavis.edu/blog/cultivating-health/what-you-should-know-about-measles-and-how-the-mmr-vaccine-can-protect-your-family/2024/11
Measles cases are on the rise globally. From 2022 to 2023, there was a 20% increase in cases, according to the World Health Organization and the U.S. Centers for Disease Control and Prevention (CDC). […] Two doses of the measles vaccine can prevent measles. However, more than 22 million children worldwide didn’t get their first dose of the measles vaccine in 2023, according to the CDC. […] The measles, mumps, and rubella (MMR) vaccine provides the best protection from measles. The MMR vaccine provides lasting protection against all strains of measles. […] High rates of MMR vaccinations in the U.S. have made measles, mumps and rubella far less common among Americans. […] The MMR vaccine is given in two doses. The first dose is typically given to babies ages 12-15 months. The second dose is given between ages 4 and 6 years old. The MMR vaccine can safely be given with other vaccines. […] Most people are protected from measles, mumps and rubella for life. […] The MMR vaccine is considered safe and effective. It provides the most effective prevention against measles, mumps and rubella. Most children have very minor side effects and no long term effects after getting the vaccine.
- #46 Health secretary RFK Jr. endorses the MMR vaccine â stoking fury among his supporters : Shots – Health News : NPRhttps://www.npr.org/sections/shots-health-news/2025/04/07/nx-s1-5354900/hhs-rfk-endorses-mmr-measles-vaccine-stoking-supporters-fury
An endorsement of the measles, mumps and rubella vaccine by Health and Human Services Secretary Robert F. Kennedy Jr. has provoked an angry outcry from anti-vaccine activists. […] „The most effective way to prevent the spread of measles is the MMR vaccine,” Kennedy said in the third paragraph of a lengthy post on the social media platform X. […] Kennedy’s endorsement is in line with all available scientific evidence on the MMR vaccine. „A single dose is roughly 93% effective at preventing illness, and the second dose gets that up to 97%,” says Dr. Paul Offit, director of the Vaccine Education Center at the Children’s Hospital in Philadelphia. […] „I’m delighted to hear what Secretary Kennedy has said about giving the vaccination,” says Dr. Kathryn Edwards, a retired professor of pediatric infectious disease.