Nietolerancja laktozy
Epidemiologia
Nietolerancja laktozy dotyka globalnie około 65-75% populacji, z różnicami geograficznymi i etnicznymi wynikającymi z historii spożycia mleka. Najnowsze metaanalizy obejmujące 62,910 osób z 89 krajów wskazują na 68% częstość występowania zaburzeń wchłaniania laktozy u osób powyżej 10 roku życia. Najniższe wskaźniki obserwuje się w Europie Północnej (2-5%), a najwyższe w Azji Wschodniej (70-100%) oraz wśród rdzennych Amerykanów (79-100%). Aktywność laktazy spada po 2 roku życia, a objawy nietolerancji najczęściej pojawiają się między 20 a 40 rokiem życia. Wyróżnia się trzy formy nietolerancji: pierwotną (70% populacji), wtórną związaną z uszkodzeniem jelita cienkiego oraz bardzo rzadką wrodzoną. Diagnostyka opiera się głównie na wodorowym teście oddechowym (wzrost H₂ >20 ppm po spożyciu laktozy), próbie eliminacyjnej oraz badaniach genetycznych, choć testy mogą dawać wyniki fałszywie dodatnie lub ujemne, zwłaszcza u osób starszych i z zespołem rozrostu bakteryjnego jelita cienkiego.
Epidemiologia nietolerancji laktozy
Nietolerancja laktozy stanowi jeden z najpowszechniejszych problemów zdrowotnych na świecie, dotykający znaczną część populacji globalnej. Szacuje się, że około 65-75% światowej populacji cierpi na nietolerancję laktozy, wykazując zmniejszoną zdolność trawienia tego cukru po okresie niemowlęcym.123 Niektóre badania sugerują, że rzeczywista częstość występowania tego schorzenia może przekraczać 65%, podczas gdy nietolerancja laktozy zdiagnozowana metodami instrumentalnymi ma globalną częstość występowania około 57%.4 Najnowsze metaanalizy obejmujące dane z 450 populacji badawczych (N = 62,910) i 89 krajów, uwzględniające osoby w wieku co najmniej 10 lat, wykazały szacowaną 68% globalną częstość występowania zaburzeń wchłaniania laktozy (standaryzowaną według wielkości kraju).5
Rozmieszczenie geograficzne
Występowanie nietolerancji laktozy wykazuje znaczne zróżnicowanie geograficzne i etniczne, co jest związane z poziomem spożycia produktów mlecznych w diecie poszczególnych populacji.6 Częstość występowania tego schorzenia jest najniższa w populacjach z długą historią zależności od niefermentowanych produktów mlecznych jako ważnego źródła pożywienia.7 W Europie Północnej nietolerancja laktozy dotyka zaledwie około 5% populacji, podczas gdy w niektórych regionach Azji odsetek ten sięga nawet 70-100%.89
W poszczególnych regionach świata częstość występowania nietolerancji laktozy przedstawia się następująco:
- Europa: około 28% populacji (z wyraźnym zróżnicowaniem między północą a południem kontynentu – od 2% w krajach skandynawskich do 70% na Sycylii)1011
- Ameryka Północna: zróżnicowana w zależności od grup etnicznych; około 20-25% białych Amerykanów, 80% Afroamerykanów, 51-80% Latynosów, 79% rdzennych Amerykanów1213
- Ameryka Południowa: 50-80%1415
- Afryka: 60-80%, ze szczególnie wysokimi wskaźnikami w Nigerii, Malawi, Sudanie, Etiopii i Ugandzie, oraz niższymi w Kamerunie, Mali, RPA i Maroku16
- Azja: 70-100%, szczególnie wysoka częstość w Azji Wschodniej1718
- Bliski Wschód: około 70%19
Zróżnicowanie etniczne
Nietolerancja laktozy wykazuje wyraźne różnice w częstości występowania między grupami etnicznymi:2021
- Populacje Azjatyckie: 70-100% osób wykazuje nietolerancję laktozy, co stanowi najwyższy odsetek globalnie2223
- Afroamerykanie: 75-90% populacji2425
- Rdzenni Amerykanie: około 80-100% populacji2627
- Latynosi/Hiszpanie: 50-80% populacji2829
- Żydzi Aszkenazyjscy: 60-80% populacji3031
- Biali pochodzenia północnoeuropejskiego: zaledwie 2-15% populacji3233
W Indiach zaobserwowano, że częstość i stopień nieprawidłowego wchłaniania laktozy są wyższe w populacjach południowoindyjskich w porównaniu z północnymi, co może wynikać z możliwych różnic genetycznych między tymi subpopulacjami.34
Wiek i płeć
Nietolerancja laktozy rzadko występuje u dzieci poniżej 5 roku życia, natomiast najczęściej obserwuje się ją u nastolatków i młodych dorosłych.35 Związek między wiekiem a zaburzeniami wchłaniania laktozy jest wyraźny – wraz z wiekiem zwiększa się częstość występowania tego problemu.36 Aktywność laktazy jest genetycznie zaprogramowana na spadek, rozpoczynający się po 2 roku życia, chociaż objawy zwykle nie stają się widoczne do 6-7 roku życia, a najnowsze badania wykazały, że hipolaktazja może rozpocząć się nawet po 20 roku życia.37
Istnieją wyraźne różnice w tempie obniżania się poziomu laktazy po odstawieniu od piersi w różnych grupach etnicznych:38
- Chińczycy i Japończycy tracą 80-90% aktywności laktazy w ciągu 3-4 lat po odstawieniu od piersi
- Żydzi i Azjaci tracą 70-80% w ciągu kilku lat po odstawieniu od piersi
- U białych Europejczyków z północy i Amerykanów z północy może upłynąć do 18-20 lat, zanim laktaza osiągnie najniższy poziom
Wśród dorosłych, wiek występowania nietolerancji laktozy wynosi zazwyczaj 20-40 lat.3940 Warto zauważyć, że początek choroby jest zwykle subtelny i postępujący w pierwotnej postaci, a wielu pacjentów doświadcza pierwszych objawów nietolerancji w późnym okresie dojrzewania i dorosłości.41
Co do płci, nietolerancja laktozy dotyka w równym stopniu mężczyzn i kobiety.4243 Jednak wśród dorosłych kobiet z nietolerancją laktozy, 44% odzyskuje zdolność trawienia laktozy podczas ciąży. Jest to prawdopodobnie spowodowane spowolnionym pasażem jelitowym i adaptacją bakteryjną w czasie ciąży.44
Typy nietolerancji laktozy
Nietolerancja laktozy występuje w kilku formach, z których każda ma różną epidemiologię:45
Pierwotna nietolerancja laktozy
Jest to najczęstsza forma (występująca u około 70% światowej populacji, choć nie wszyscy są objawowi). Wynika z genetycznie zaprogramowanego, stopniowego zmniejszania się aktywności enzymu laktazy w jelicie cienkim.4647 Pierwotna nietolerancja laktozy jest normalnym procesem fizjologicznym u większości ludzi na świecie, podczas gdy utrzymywanie się zdolności do trawienia laktozy w dorosłości (przetrwanie laktazy) jest właściwie mutacją genetyczną, która zapewnia przewagę selekcyjną grupom wykorzystującym produkty mleczne.48
Wtórna nietolerancja laktozy
Może wystąpić w każdym wieku i jest spowodowana uszkodzeniem błony śluzowej jelita cienkiego przez choroby, infekcje lub urazy.49 Jest częstsza u dzieci, szczególnie w krajach rozwijających się, gdzie infekcje są powszechną przyczyną.5051 Około 50% niemowląt z biegunką będzie miało wtórną nietolerancję laktozy.52 Choroby powodujące wtórną nietolerancję laktozy obejmują: rotawirus, giardię i inne infekcje pasożytnicze, choroby zapalne jelit, celiakię, mukowiscydozę i AIDS.53
Wrodzona nietolerancja laktozy
Jest niezwykle rzadka (około 40 przypadków zgłoszonych na całym świecie do chwili obecnej). Jest to bardzo rzadkie zaburzenie genetyczne, które ma tendencję do występowania w populacji fińskiej.545556
Współwystępowanie z innymi chorobami
Nietolerancja laktozy wydaje się mieć wyższą częstość występowania u pacjentów z zespołem jelita drażliwego z przewagą biegunki (IBS-D) niż u zdrowych osób.57 Nietrwałość laktazy nie wydaje się być związana z innymi chorobami trawiennymi, chociaż wykazano, że osoby z zespołem jelita drażliwego mają większe prawdopodobieństwo wystąpienia nietolerancji laktozy niż populacja ogólna.58
Nietolerancja laktozy jest również częstsza w przypadkach z aktywnymi etiologiami żołądkowo-jelitowymi, takimi jak wrzodziejące zapalenie jelita grubego, które są wskazywane jako przyczyna wtórnej nietolerancji laktozy.59
Nadzór i diagnostyka
Nadzór nad nietolerancją laktozy obejmuje różne metody diagnostyczne, które pomagają w prawidłowym rozpoznaniu tego schorzenia. Jest to istotne, ponieważ dokładna diagnoza nietolerancji laktozy może znacznie złagodzić niepokój pacjenta i uniknąć nieodpowiedniego badania i leczenia.60
Metody diagnostyczne
Istnieje kilka metod stosowanych do diagnozowania nietolerancji laktozy:6162
- Wodorowy test oddechowy (HBT) – jest to najczęściej stosowany test diagnostyczny dla nietolerancji laktozy. Badanie to opiera się na wykrywaniu wodoru w wydychanym powietrzu, który powstaje w wyniku fermentacji niestrawionej laktozy przez mikroflorę okrężnicy. Wzrost ilości wodoru w oddechu o więcej niż 20 ppm w porównaniu do wartości wyjściowej po spożyciu laktozy wskazuje na nietolerancję laktozy.6364
- Próba eliminacyjna – polega na wykluczeniu produktów zawierających laktozę z diety na określony czas, a następnie ich ponownym wprowadzeniu. Jeśli objawy ustępują podczas eliminacji, a powracają po ponownym wprowadzeniu produktów mlecznych, prawdopodobnie występuje nietolerancja laktozy.6566
- Badania genetyczne – mogą być przydatne w identyfikowaniu osób z pierwotną nietolerancją laktozy, szczególnie w populacjach o wysokim ryzyku.6768
Warto zaznaczyć, że znaczna liczba osób, które mają objawy sugerujące nietolerancję laktozy, będzie miała normalne wyniki testów diagnostycznych.69 Ponadto test oddechowy wodorowy może prowadzić do fałszywie dodatnich wyników związanych ze zwiększoną produkcją H₂ w przypadku zespołu rozrostu bakteryjnego jelita cienkiego oraz fałszywie ujemnych wyników, na przykład u osób, które nie produkują H₂.70
Wyzwania diagnostyczne u osób starszych
Testowanie w kierunku zaburzeń wchłaniania laktozy może być trudne u osób starszych, a czasem nawet bezużyteczne. Zamiast tego, zawsze należy dążyć do szczegółowej oceny klinicznej w celu identyfikacji zarówno nietolerancji laktozy, jak i wszystkich czynników zakłócających dających ten sam obraz kliniczny.71
Mechanizmy leżące u podstaw wyższej częstości występowania zaburzeń wchłaniania laktozy w podeszłym wieku nie są do końca jasne. Sugeruje się, że zjawisko to może wynikać z procesu starzenia się jelit, charakteryzującego się podwyższonym obrotem enterocytów z konsekwentnym zwiększonym odsetkiem niedojrzałych komórek nabłonka kosmków o zredukowanej ekspresji laktazy.72
Znaczenie dokładnej diagnozy
Dokładna diagnoza nietolerancji laktozy jest niezwykle ważna, aby zapobiec samodiagnozie, która skutkuje niepotrzebnym eliminowaniem mleka i produktów mlecznych z diety i wynikającym z tego pozbawieniem składników odżywczych, które mogą być niezbędne na pewnych etapach życia.73
Subiektywne postrzeganie nietolerancji laktozy wpływa na decyzję o unikaniu nabiału nawet bardziej niż obiektywne zaburzenia wchłaniania. Jednak zarówno własne postrzeganie nietolerancji laktozy, jak i obiektywne zaburzenia wchłaniania laktozy są związane z gorszą postrzeganą jakością życia.74
| Region/Populacja | Częstość występowania nietolerancji laktozy (%) | Czynniki wpływające |
|---|---|---|
| Europa Północna | 2-5% | Długa historia spożycia mleka, adaptacja genetyczna |
| Europa Południowa | do 70% | Zróżnicowanie historycznych wzorców żywieniowych |
| Afrykanie/Afroamerykanie | 60-80% | Mniejsza historyczna zależność od nabiału |
| Azjaci/Azjaci-Amerykanie | 70-100% | Najwyższy odsetek, tradycyjnie dieta bez mleka u dorosłych |
| Latynosi | 50-80% | Zróżnicowane wzorce w zależności od pochodzenia |
| Rdzenni Amerykanie | 79-100% | Bardzo wysoki odsetek |
| Żydzi Aszkenazyjscy | 60-80% | Wyższy odsetek niż w populacji europejskiej |
| Bliski Wschód | 70% | Wysoki odsetek, zróżnicowany regionalnie |
| Dzieci poniżej 5 lat | 0-20% | Niski odsetek, zależny od pochodzenia etnicznego |
| Dorośli (20-40 lat) | Wzrasta z wiekiem | Typowy wiek wystąpienia pierwotnej nietolerancji |
Znaczenie kliniczne i implikacje zdrowotne
Nietolerancja laktozy, choć jest częstym schorzeniem, rzadko stanowi zagrożenie dla życia. Może jednak mieć istotne implikacje dla zdrowia i jakości życia pacjentów.7576
Osoby, które ignorują swoją nietolerancję laktozy i nadal spożywają zbyt dużo produktów mlecznych, ryzykują nasilenie objawów i rozwój dalszych powikłań zdrowotnych.77 Objawy nietolerancji laktozy mogą wpływać na jakość życia i nastrój osoby.78
Nietolerancja laktozy może również utrudniać uzyskanie odpowiedniej ilości ważnych witamin i minerałów. Może to prowadzić do niezdrowej utraty wagi i zwiększać ryzyko rozwoju następujących stanów:79
- Osteopenia – gdzie występuje bardzo niska gęstość mineralna kości. Jeśli osteopenia nie jest leczona, może rozwinąć się w osteoporozę.
- Osteoporoza – gdzie kości stają się cienkie i słabe. W przypadku osteoporozy ryzyko złamań i złamań kości jest zwiększone.
- Niedożywienie – gdy spożywane pokarmy nie dostarczają składników odżywczych niezbędnych do zdrowego funkcjonowania organizmu. W przypadku niedożywienia rany mogą dłużej się goić, a pacjent może zacząć odczuwać zmęczenie lub depresję.
Nietolerancja laktozy może być szczególnie szkodliwa dla kobiet, ponieważ może zwiększać ryzyko problemów zdrowotnych, takich jak osteoporoza. Kobiety szczególnie potrzebują wystarczającej ilości wapnia i witaminy D przez całe życie, aby pomóc w budowaniu i utrzymaniu gęstości kości oraz zmniejszeniu ryzyka osteoporozy w późniejszym życiu.80
Implikacje dla zdrowia publicznego
Biorąc pod uwagę wysoką częstość występowania nietolerancji laktozy na świecie, schorzenie to ma istotne implikacje dla zdrowia publicznego, szczególnie w kontekście zaleceń żywieniowych i strategii zapobiegania niedoborom składników odżywczych.81
Zmniejszone spożycie mleka może prowadzić do niedoborów żywieniowych. Według badań, spożycie ryboflawiny, wapnia, fosforu i potasu znacząco różni się w zależności od częstotliwości spożycia mleka.82
W zarządzaniu nietolerancją laktozy należy unikać nadmiernie restrykcyjnych diet. Ponieważ produkty mleczne są znaczącym źródłem niezbędnych składników odżywczych, takich jak wapń, witamina D, fosfor i witamina B12, które są istotne dla zdrowia kości, ważne jest znalezienie alternatywnych źródeł tych składników lub stosowanie odpowiednich suplementów.8384
Warto zauważyć, że produkty bez laktozy są opracowane w taki sposób, aby zapewniać taką samą zawartość odżywczą jak tradycyjne produkty mleczne, zapewniając osobom z nietolerancją laktozy możliwość otrzymywania niezbędnych składników odżywczych bez doświadczania dyskomfortu trawiennego.85
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Materiały źródłowe
- #1 Lactose Intolerance | Treatment & Management | Point of Carehttps://www.statpearls.com/point-of-care/24003
Lactose intolerance is a common disease; however, it is rare in children younger than 5. It is most often seen in adolescents and young adults. On average, 65% of the world’s population is lactose intolerant. The prevalence of lactose intolerance is variable among different ethnicities. It is most common in African Americans, Hispanics/Latinos, and Asians and least prevalent in people of European descent. Ethnic groups with a higher prevalence of lactose intolerance also are more likely to have lactose non-persistence. […] The primary form is the commonest (found in up to 70% of the world’s population, but not all of them are symptomatic). On the contrary, the congenital type is extremely rare (with around 40 cases reported worldwide to date). […] In the US, the primary disease is much more common in certain ethnicities, such as African-Americans, American Indians, Hispanics or Latinos, and Asian-Americans, than in White Americans. North Americans, Australians, and White Northern Europeans have the lowest rates, ranging between 2% and 15%. On the contrary, the prevalence of lactose intolerance is 50% to 80% in South Americans, around 100% in American Indians and some East Asians, and around 60% to 80% in Ashkenazi Jews and Africans.
- #2 Lactose intolerance: MedlinePlus GeneticsLockhttps://medlineplus.gov/genetics/condition/lactose-intolerance/
Lactose intolerance is a condition that makes it difficult to digest lactose, a sugar found in milk and several other dairy products. […] Approximately 65 percent of the human population has a reduced ability to digest lactose after infancy. Lactase nonpersistence is most prevalent in people of East Asian descent, with 70 to 100 percent of people affected in these communities. […] The prevalence of lactose intolerance is lowest in populations with a long history of dependence on unfermented milk products as an important food source. For example, only about 5 percent of people of Northern European descent are lactase nonpersistent.
- #3 Prebiotic Strategies to Manage Lactose Intolerance Symptomshttps://www.mdpi.com/2072-6643/16/7/1002
Lactose intolerance, which affects about 65â75% of the worldâs population, is caused by a genetic post-weaning deficiency of lactase, the enzyme required to digest the milk sugar lactose, called lactase non-persistence. […] Approximately 65â75% of humans are lactase non-persistent (LNP), in that they do not express adequate lactase post-weaning, resulting in gastrointestinal symptoms, such as bloating, flatulence, diarrhea and nausea, when lactose is consumed. […] About 65â75% of humans globally display LNP and are, therefore, intolerant to foods with large amounts of lactose. […] The main management strategies for LI are reducing or eliminating the consumption of lactose-containing foods and consuming supplemental lactase enzymes with lactose-containing meals. […] The diagnosis of LI predominantly relies on self-identification of symptoms after the consumption of lactose-containing foods in individuals with LNP. […] The hydrogen breath test (HBT) is a cost-effective, non-invasive, and simple diagnostic method for LI. […] The primary management strategy for LI involves avoiding lactose-containing foods.
- #4https://link.springer.com/article/10.1007/s42399-021-00792-9
Lactose intolerance diagnosed with instrumental methods has a global prevalence of about 57%. Instead, it is estimated that the real prevalence exceeds 65%. This condition has a prevalence of about 50% in South America, Africa, and Asia. In the USA, the prevalence is 15% among whites, 53% among Mexican-Americans, and 80% in the Black population. In Europe, the prevalence is about 28%, with variable percentages between the North and South of the continent. Indeed, it varies from 2% in Scandinavia to about 70% in Sicily. […] The global prevalence of this clinical condition is estimated of about 57% with instrumental methods, while the real prevalence exceeds 65%.
- #5 Pediatric Lactose Intolerance: Background, Pathophysiology, Etiologyhttps://emedicine.medscape.com/article/930971-overview
Lactose intolerance in adulthood is very common and is the result of a genetically programmed progressive loss of the activity of the small intestinal enzyme lactase. […] An estimated 68-70% of the global population has lactose intolerance. […] Adult-onset lactase deficiency varies widely among countries. […] Although as many as 20-25% of White US adults are believed to be lactase deficient, the true prevalence of this condition is unknown, as noted in a comprehensive National Institute of Health (NIH) consensus conference on the topic. […] The prevalence in other racial groups parallels the country of racial origin. […] A systematic review and meta-analysis of the MEDLINE and Embase literature from inception to late 2016 comprising data from 450 study populations (N = 62,910) and 89 countries of individuals at least 10 years old found an estimated 68% global prevalence of lactose malabsorption (standardized for country size).
- #6 Lactose Intolerance (Causes, Symptoms, and Treatment)https://patient.info/doctor/lactose-intolerance-pro
How common is lactose intolerance? (Epidemiology) […] The global prevalence of lactose malabsorption is estimated to be 68%, ranging from 28% in Western, Southern, and Northern Europe, to 70% in the Middle East. […] There is wide geographical and ethnic variation in the age-related decline in lactase levels. This is related to the level of dairy consumption in the diet. […] The prevalence of high lactase levels in adulthood is highest in Northern European populations and lowest in black and East Asiatic communities where, traditionally, the adult diet does not include milk. People who lose lactase activity more quickly after weaning will present earlier with symptoms. […] Chinese and Japanese people lose 80% to 90% of lactase activity within 3 to 4 years after weaning; Jewish and Asian people lose 70% to 80% over several years after weaning; and in white Northern Europeans and North Americans it may take up to 18 to 20 years for lactase to reach its lowest levels.
- #7 Lactose intolerance: MedlinePlus GeneticsLockhttps://medlineplus.gov/genetics/condition/lactose-intolerance/
Lactose intolerance is a condition that makes it difficult to digest lactose, a sugar found in milk and several other dairy products. […] Approximately 65 percent of the human population has a reduced ability to digest lactose after infancy. Lactase nonpersistence is most prevalent in people of East Asian descent, with 70 to 100 percent of people affected in these communities. […] The prevalence of lactose intolerance is lowest in populations with a long history of dependence on unfermented milk products as an important food source. For example, only about 5 percent of people of Northern European descent are lactase nonpersistent.
- #8 Lactose intolerance – Wikipediahttps://en.wikipedia.org/wiki/Lactose_intolerance
Worldwide, about 65% of people experience some form of lactose intolerance as they age past infancy, but there are significant differences between populations and regions. […] As few as 5% of northern Europeans are lactose intolerant, while as many as 90% of adults in parts of Asia are lactose intolerant. […] Lactose intolerance is common among people of Jewish descent, as well as from West Africa, the Arab countries, Greece, and Italy. […] Different populations will present certain gene constructs depending on the evolutionary and cultural pre-settings of the geographical region.
- #9 Lactose Intolerance by Country 2025https://worldpopulationreview.com/country-rankings/lactose-intolerance-by-country
Lactose intolerance is a digestive disorder caused by the inability to digest lactose. […] About 65% of the adult human population has this type of lactose intolerance. […] The disorder is relatively very common, affecting millions of people in the U.S. alone. […] Lactose intolerance is generally most common in Asian countries, especially in East Asian, where about 70-100% of people show lactose intolerance; it is least prevent in Northern and Central Europe, where only about 5% of the population has lactose intolerance.
- #10 Lactose Intolerance (Causes, Symptoms, and Treatment)https://patient.info/doctor/lactose-intolerance-pro
How common is lactose intolerance? (Epidemiology) […] The global prevalence of lactose malabsorption is estimated to be 68%, ranging from 28% in Western, Southern, and Northern Europe, to 70% in the Middle East. […] There is wide geographical and ethnic variation in the age-related decline in lactase levels. This is related to the level of dairy consumption in the diet. […] The prevalence of high lactase levels in adulthood is highest in Northern European populations and lowest in black and East Asiatic communities where, traditionally, the adult diet does not include milk. People who lose lactase activity more quickly after weaning will present earlier with symptoms. […] Chinese and Japanese people lose 80% to 90% of lactase activity within 3 to 4 years after weaning; Jewish and Asian people lose 70% to 80% over several years after weaning; and in white Northern Europeans and North Americans it may take up to 18 to 20 years for lactase to reach its lowest levels.
- #11https://link.springer.com/article/10.1007/s42399-021-00792-9
Lactose intolerance diagnosed with instrumental methods has a global prevalence of about 57%. Instead, it is estimated that the real prevalence exceeds 65%. This condition has a prevalence of about 50% in South America, Africa, and Asia. In the USA, the prevalence is 15% among whites, 53% among Mexican-Americans, and 80% in the Black population. In Europe, the prevalence is about 28%, with variable percentages between the North and South of the continent. Indeed, it varies from 2% in Scandinavia to about 70% in Sicily. […] The global prevalence of this clinical condition is estimated of about 57% with instrumental methods, while the real prevalence exceeds 65%.
- #12 Lactose intolerance epidemiology and demographics – wikidochttps://www.wikidoc.org/index.php/Lactose_intolerance_epidemiology_and_demographics
The prevalence of lactose intolerance is approximately 75,000 per 100,000 individuals worldwide. […] The prevalence of lactose intolerance is low in children younger than six years. […] Europeans and European Americans individuals are less likely to develop lactose intolerance. […] Lactose intolerance affects men and women equally. […] The majority of lactose intolerance cases are reported in the Far East. […] The prevalence of lactose intolerance is up to 75000 per 100,000 individuals worldwide. […] In North America, the prevalence of lactose intolerance: Native America: 79000 per 100,000 individuals, Black: 75000 per 100,000 individuals, Hispanics: 51000 per 100,000 individuals, Caucasians: 21000 per 100,000 individuals. […] The prevalence of lactose intolerance in Latin America, Africa, and Asia is 15000-100000 per 100,000 individuals.
- #13 Lactose Intolerance | AAFPhttps://www.aafp.org/pubs/afp/issues/2002/0501/p1845.html
Persons with lactose intolerance are unable to digest significant amounts of lactose because of a genetically inadequate amount of the enzyme lactase. […] Lactase deficiency is present in up to 15 percent of persons of northern European descent, up to 80 percent of blacks and Latinos, and up to 100 percent of American Indians and Asians. […] The most common form of lactase deficiency is primary adult hypolactasia. […] However, the prevalence of hypolactasia varies widely among ethnic backgrounds. Estimates range from 2 percent in persons from Northern Europe to nearly 100 percent in adult Asians and American Indians. Blacks and Ashkenazi Jews have prevalences of 60 to 80 percent, and Latinos have a prevalence of 50 to 80 percent. […] The wide variation in prevalence has caused speculation that lactase deficiency is the normal or natural state, and the persistence of significant lactase activity into adult life in northern European populations is an abnormal mutation that provides a selective advantage to groups using dairy products. […] Lactose intolerance is generally a lifelong inherited condition but can be a temporary result of an infection or other insult to the jejunal mucosa. […] Accurate diagnosis of lactose intolerance can significantly relieve patient anxiety and avoid inappropriate investigation and treatment.
- #14 Lactose Intolerance | Treatment & Management | Point of Carehttps://www.statpearls.com/point-of-care/24003
Lactose intolerance is a common disease; however, it is rare in children younger than 5. It is most often seen in adolescents and young adults. On average, 65% of the world’s population is lactose intolerant. The prevalence of lactose intolerance is variable among different ethnicities. It is most common in African Americans, Hispanics/Latinos, and Asians and least prevalent in people of European descent. Ethnic groups with a higher prevalence of lactose intolerance also are more likely to have lactose non-persistence. […] The primary form is the commonest (found in up to 70% of the world’s population, but not all of them are symptomatic). On the contrary, the congenital type is extremely rare (with around 40 cases reported worldwide to date). […] In the US, the primary disease is much more common in certain ethnicities, such as African-Americans, American Indians, Hispanics or Latinos, and Asian-Americans, than in White Americans. North Americans, Australians, and White Northern Europeans have the lowest rates, ranging between 2% and 15%. On the contrary, the prevalence of lactose intolerance is 50% to 80% in South Americans, around 100% in American Indians and some East Asians, and around 60% to 80% in Ashkenazi Jews and Africans.
- #15 Lactose intolerance – Walter Bushnell Healthcare Foundationhttps://wbhf.walterbushnell.com/publications/bush-beats/item/56-lactose-intolerance
Lactose intolerance is the most common problem limiting milk and dairy products consumption worldwide and is defined as experience of gastrointestinal symptoms following the intake of lactose-containing food products. […] It is suggested that only about 35% of people worldwide are lactase persistent who continue to produce lactase throughout adulthood and thus are able to digest the sugar in milk without discomfort. […] This clearly signifies that lactase non-persistence would be highly prevalent across the world even if in different severity forms. Especially the impact could be more on Asians and American Indians due to high prevalence of lactase deficiency in these populations. Data in this context has shown that lactase deficiency can be seen in up to 15% of persons of Northern European descent up to 80% of blacks and Latinos and up to 100% of American Indians and Asians.
- #16 Lactose intolerance epidemiology and demographics – wikidochttps://www.wikidoc.org/index.php/Lactose_intolerance_epidemiology_and_demographics
The prevalence of lactose intolerance is low in children younger than six years. […] The prevalence of lactose intolerance increases with age. […] Lactose intolerance usually affects the following populations: African Americans, Hispanics, Asians, Asian Americans, Native Americans. […] Europeans and European Americans are less likely to develop lactose intolerance. […] Lactose intolerance affects men and women equally. […] The majority of lactose intolerance cases are reported in the Far East. […] Northwestern Europe has the lowest prevalence of lactose intolerance. […] The following countries have the highest rates of lactose intolerance in Africa: Nigeria, Malawi, Sudan, Ethiopia, Uganda. […] The following countries have the lowest rates of lactose intolerance in Africa: Cameroon, Mali, South Africa, Morocco. […] Congenital lactase deficiency is a rare disease that tends to affect Finnish population. […] Secondary lactase deficiency is more common in children, particularly in the developing countries due to high prevalence of infections.
- #17 Lactose intolerance: MedlinePlus GeneticsLockhttps://medlineplus.gov/genetics/condition/lactose-intolerance/
Lactose intolerance is a condition that makes it difficult to digest lactose, a sugar found in milk and several other dairy products. […] Approximately 65 percent of the human population has a reduced ability to digest lactose after infancy. Lactase nonpersistence is most prevalent in people of East Asian descent, with 70 to 100 percent of people affected in these communities. […] The prevalence of lactose intolerance is lowest in populations with a long history of dependence on unfermented milk products as an important food source. For example, only about 5 percent of people of Northern European descent are lactase nonpersistent.
- #18 Lactose intolerance epidemiology and demographics – wikidochttps://www.wikidoc.org/index.php/Lactose_intolerance_epidemiology_and_demographics
The prevalence of lactose intolerance is approximately 75,000 per 100,000 individuals worldwide. […] The prevalence of lactose intolerance is low in children younger than six years. […] Europeans and European Americans individuals are less likely to develop lactose intolerance. […] Lactose intolerance affects men and women equally. […] The majority of lactose intolerance cases are reported in the Far East. […] The prevalence of lactose intolerance is up to 75000 per 100,000 individuals worldwide. […] In North America, the prevalence of lactose intolerance: Native America: 79000 per 100,000 individuals, Black: 75000 per 100,000 individuals, Hispanics: 51000 per 100,000 individuals, Caucasians: 21000 per 100,000 individuals. […] The prevalence of lactose intolerance in Latin America, Africa, and Asia is 15000-100000 per 100,000 individuals.
- #19 Lactose Intolerance (Causes, Symptoms, and Treatment)https://patient.info/doctor/lactose-intolerance-pro
How common is lactose intolerance? (Epidemiology) […] The global prevalence of lactose malabsorption is estimated to be 68%, ranging from 28% in Western, Southern, and Northern Europe, to 70% in the Middle East. […] There is wide geographical and ethnic variation in the age-related decline in lactase levels. This is related to the level of dairy consumption in the diet. […] The prevalence of high lactase levels in adulthood is highest in Northern European populations and lowest in black and East Asiatic communities where, traditionally, the adult diet does not include milk. People who lose lactase activity more quickly after weaning will present earlier with symptoms. […] Chinese and Japanese people lose 80% to 90% of lactase activity within 3 to 4 years after weaning; Jewish and Asian people lose 70% to 80% over several years after weaning; and in white Northern Europeans and North Americans it may take up to 18 to 20 years for lactase to reach its lowest levels.
- #20 Lactose Intolerance | Treatment & Management | Point of Carehttps://www.statpearls.com/point-of-care/24003
Lactose intolerance is a common disease; however, it is rare in children younger than 5. It is most often seen in adolescents and young adults. On average, 65% of the world’s population is lactose intolerant. The prevalence of lactose intolerance is variable among different ethnicities. It is most common in African Americans, Hispanics/Latinos, and Asians and least prevalent in people of European descent. Ethnic groups with a higher prevalence of lactose intolerance also are more likely to have lactose non-persistence. […] The primary form is the commonest (found in up to 70% of the world’s population, but not all of them are symptomatic). On the contrary, the congenital type is extremely rare (with around 40 cases reported worldwide to date). […] In the US, the primary disease is much more common in certain ethnicities, such as African-Americans, American Indians, Hispanics or Latinos, and Asian-Americans, than in White Americans. North Americans, Australians, and White Northern Europeans have the lowest rates, ranging between 2% and 15%. On the contrary, the prevalence of lactose intolerance is 50% to 80% in South Americans, around 100% in American Indians and some East Asians, and around 60% to 80% in Ashkenazi Jews and Africans.
- #21 Lactose Intolerance: Background, Pathophysiology, Etiologyhttps://emedicine.medscape.com/article/187249-overview
The prevalence of primary lactose intolerance varies according to race. As many as 25% of the white population (prevalence in those from southern European roots) is estimated to have lactose intolerance, while among black, Native American, and Asian American populations, the prevalence of lactose intolerance is estimated at 75-90%. […] An estimated 70-75% off the world’s population is lactose-deficient. Lactose intolerance is very common among Asian, South American, and African persons. […] Lactose intolerance also appears to have a higher prevalence in patients with diarrhea-predominant irritable bowel syndrome (IBS-D) than healthy individuals. […] Persons of all races are affected by lactose intolerance, with a higher prevalence among Asian, African, and South American persons. […] Males and females are equally affected by lactose intolerance. However, of adult women who are lactose intolerant, 44% regain the ability to digest lactose during pregnancy. This is probably due to slow intestinal transit and bacterial adaptation during pregnancy.
- #22 Lactose Intolerance Market Size & Share | Forecast – 2035https://www.imarcgroup.com/lactose-intolerance-market
Lactose intolerance is most common in persons of East Asian heritage, with 70 to 100 percent of those affected in these cultures. […] 80 percent of all Native Americans and African-Americans are lactose intolerant. […] Lactose intolerance typically manifests in adults between the ages of 20 and 40. […] What is the number of prevalent cases (2019-2035) of lactose intolerance across the seven major markets? […] What is the size of the lactose intolerance patient pool (2019-2024) across the seven major markets? […] What would be the forecasted patient pool (2025-2035) across the seven major markets? […] What are the key factors driving the epidemiological trend of lactose intolerance? […] What will be the growth rate of patients across the seven major markets?
- #23 Lactose Intolerance | University Hospitalshttps://www.uhhospitals.org/health-information/health-and-wellness-library/article/diseases-and-conditions/lactose-intolerance
Lactose intolerance is most common in Asian Americans, African Americans, Mexican Americans, and Native Americans. […] The most common symptoms of lactose intolerance are belly cramps and pain, nausea, bloating, gas, and diarrhea. […] There is no treatment that can help your body make more lactase. […] You can manage your symptoms by changing your diet. Or you can take enzyme supplements when you eat or drink foods that have lactose.
- #24 Lactose Intolerance: Background, Pathophysiology, Etiologyhttps://emedicine.medscape.com/article/187249-overview
The prevalence of primary lactose intolerance varies according to race. As many as 25% of the white population (prevalence in those from southern European roots) is estimated to have lactose intolerance, while among black, Native American, and Asian American populations, the prevalence of lactose intolerance is estimated at 75-90%. […] An estimated 70-75% off the world’s population is lactose-deficient. Lactose intolerance is very common among Asian, South American, and African persons. […] Lactose intolerance also appears to have a higher prevalence in patients with diarrhea-predominant irritable bowel syndrome (IBS-D) than healthy individuals. […] Persons of all races are affected by lactose intolerance, with a higher prevalence among Asian, African, and South American persons. […] Males and females are equally affected by lactose intolerance. However, of adult women who are lactose intolerant, 44% regain the ability to digest lactose during pregnancy. This is probably due to slow intestinal transit and bacterial adaptation during pregnancy.
- #25 Lactose Intolerance | Boston Children’s Hospitalhttps://www.childrenshospital.org/conditions/lactose-intolerance
Lactase is an enzyme that is normally produced in the small intestine, where it breaks down lactose into a form that can be absorbed by the blood. A lack of lactase can cause uncomfortable symptoms for some people; those who exhibit symptoms are said to be „lactose intolerant.” Thirty to 50 million Americans are lactose intolerant. 80 percent of all African-Americans and Native Americans are lactose intolerant. Over 90 percent of Asian-Americans are lactose intolerant, and it is least common among Americans with a Northern European heritage. […] In young children, lactose intolerance is usually caused by digestive diseases or injuries to the small intestine. But most cases of lactose intolerance develop over a period of many years in adolescents and adults.
- #26 Lactose Intolerance | AAFPhttps://www.aafp.org/pubs/afp/issues/2002/0501/p1845.html
Persons with lactose intolerance are unable to digest significant amounts of lactose because of a genetically inadequate amount of the enzyme lactase. […] Lactase deficiency is present in up to 15 percent of persons of northern European descent, up to 80 percent of blacks and Latinos, and up to 100 percent of American Indians and Asians. […] The most common form of lactase deficiency is primary adult hypolactasia. […] However, the prevalence of hypolactasia varies widely among ethnic backgrounds. Estimates range from 2 percent in persons from Northern Europe to nearly 100 percent in adult Asians and American Indians. Blacks and Ashkenazi Jews have prevalences of 60 to 80 percent, and Latinos have a prevalence of 50 to 80 percent. […] The wide variation in prevalence has caused speculation that lactase deficiency is the normal or natural state, and the persistence of significant lactase activity into adult life in northern European populations is an abnormal mutation that provides a selective advantage to groups using dairy products. […] Lactose intolerance is generally a lifelong inherited condition but can be a temporary result of an infection or other insult to the jejunal mucosa. […] Accurate diagnosis of lactose intolerance can significantly relieve patient anxiety and avoid inappropriate investigation and treatment.
- #27 Lactose Intolerance | Boston Children’s Hospitalhttps://www.childrenshospital.org/conditions/lactose-intolerance
Lactase is an enzyme that is normally produced in the small intestine, where it breaks down lactose into a form that can be absorbed by the blood. A lack of lactase can cause uncomfortable symptoms for some people; those who exhibit symptoms are said to be „lactose intolerant.” Thirty to 50 million Americans are lactose intolerant. 80 percent of all African-Americans and Native Americans are lactose intolerant. Over 90 percent of Asian-Americans are lactose intolerant, and it is least common among Americans with a Northern European heritage. […] In young children, lactose intolerance is usually caused by digestive diseases or injuries to the small intestine. But most cases of lactose intolerance develop over a period of many years in adolescents and adults.
- #28 Lactose Intolerance | AAFPhttps://www.aafp.org/pubs/afp/issues/2002/0501/p1845.html
Persons with lactose intolerance are unable to digest significant amounts of lactose because of a genetically inadequate amount of the enzyme lactase. […] Lactase deficiency is present in up to 15 percent of persons of northern European descent, up to 80 percent of blacks and Latinos, and up to 100 percent of American Indians and Asians. […] The most common form of lactase deficiency is primary adult hypolactasia. […] However, the prevalence of hypolactasia varies widely among ethnic backgrounds. Estimates range from 2 percent in persons from Northern Europe to nearly 100 percent in adult Asians and American Indians. Blacks and Ashkenazi Jews have prevalences of 60 to 80 percent, and Latinos have a prevalence of 50 to 80 percent. […] The wide variation in prevalence has caused speculation that lactase deficiency is the normal or natural state, and the persistence of significant lactase activity into adult life in northern European populations is an abnormal mutation that provides a selective advantage to groups using dairy products. […] Lactose intolerance is generally a lifelong inherited condition but can be a temporary result of an infection or other insult to the jejunal mucosa. […] Accurate diagnosis of lactose intolerance can significantly relieve patient anxiety and avoid inappropriate investigation and treatment.
- #29 Lactose Intolerance Market Size & Share | Forecast – 2035https://www.imarcgroup.com/lactose-intolerance-market
Lactose intolerance is most common in persons of East Asian heritage, with 70 to 100 percent of those affected in these cultures. […] 80 percent of all Native Americans and African-Americans are lactose intolerant. […] Lactose intolerance typically manifests in adults between the ages of 20 and 40. […] What is the number of prevalent cases (2019-2035) of lactose intolerance across the seven major markets? […] What is the size of the lactose intolerance patient pool (2019-2024) across the seven major markets? […] What would be the forecasted patient pool (2025-2035) across the seven major markets? […] What are the key factors driving the epidemiological trend of lactose intolerance? […] What will be the growth rate of patients across the seven major markets?
- #30 Lactose Intolerance | AAFPhttps://www.aafp.org/pubs/afp/issues/2002/0501/p1845.html
Persons with lactose intolerance are unable to digest significant amounts of lactose because of a genetically inadequate amount of the enzyme lactase. […] Lactase deficiency is present in up to 15 percent of persons of northern European descent, up to 80 percent of blacks and Latinos, and up to 100 percent of American Indians and Asians. […] The most common form of lactase deficiency is primary adult hypolactasia. […] However, the prevalence of hypolactasia varies widely among ethnic backgrounds. Estimates range from 2 percent in persons from Northern Europe to nearly 100 percent in adult Asians and American Indians. Blacks and Ashkenazi Jews have prevalences of 60 to 80 percent, and Latinos have a prevalence of 50 to 80 percent. […] The wide variation in prevalence has caused speculation that lactase deficiency is the normal or natural state, and the persistence of significant lactase activity into adult life in northern European populations is an abnormal mutation that provides a selective advantage to groups using dairy products. […] Lactose intolerance is generally a lifelong inherited condition but can be a temporary result of an infection or other insult to the jejunal mucosa. […] Accurate diagnosis of lactose intolerance can significantly relieve patient anxiety and avoid inappropriate investigation and treatment.
- #31 Lactose intolerance – Wikipediahttps://en.wikipedia.org/wiki/Lactose_intolerance
Worldwide, about 65% of people experience some form of lactose intolerance as they age past infancy, but there are significant differences between populations and regions. […] As few as 5% of northern Europeans are lactose intolerant, while as many as 90% of adults in parts of Asia are lactose intolerant. […] Lactose intolerance is common among people of Jewish descent, as well as from West Africa, the Arab countries, Greece, and Italy. […] Different populations will present certain gene constructs depending on the evolutionary and cultural pre-settings of the geographical region.
- #32 Lactose Intolerance | Treatment & Management | Point of Carehttps://www.statpearls.com/point-of-care/24003
Lactose intolerance is a common disease; however, it is rare in children younger than 5. It is most often seen in adolescents and young adults. On average, 65% of the world’s population is lactose intolerant. The prevalence of lactose intolerance is variable among different ethnicities. It is most common in African Americans, Hispanics/Latinos, and Asians and least prevalent in people of European descent. Ethnic groups with a higher prevalence of lactose intolerance also are more likely to have lactose non-persistence. […] The primary form is the commonest (found in up to 70% of the world’s population, but not all of them are symptomatic). On the contrary, the congenital type is extremely rare (with around 40 cases reported worldwide to date). […] In the US, the primary disease is much more common in certain ethnicities, such as African-Americans, American Indians, Hispanics or Latinos, and Asian-Americans, than in White Americans. North Americans, Australians, and White Northern Europeans have the lowest rates, ranging between 2% and 15%. On the contrary, the prevalence of lactose intolerance is 50% to 80% in South Americans, around 100% in American Indians and some East Asians, and around 60% to 80% in Ashkenazi Jews and Africans.
- #33 Lactose Intolerance | 5-Minute Pediatric Consulthttps://peds.unboundmedicine.com/pedscentral/view/5-Minute-Pediatric-Consult/617644/all/Lactose_Intolerance?q=Diarrhea
Lactose intolerance is defined as the inability to digest the ingested disaccharide lactose, secondary to a deficiency of the intrinsic enzyme lactase, resulting in clinical symptoms. […] ~70% of the worlds population is prone to developing primary lactase deficiency by adulthood. […] The prevalence of primary lactase deficiency in northern Europeans, who have a diet rich in dairy, is 2%. […] In Hispanic populations, the prevalence of primary lactase deficiency is 5080%. […] In Ashkenazi Jewish and African American populations, the prevalence is 6080%. […] In Asian populations, the prevalence of primary lactase deficiency is nearly 100%. […] Nearly 20% of children 5 years from Hispanic, Asian, or African American descent have lactase deficiency and lactose malabsorption. […] Caucasian children usually do not develop symptoms until after 5 years of age.
- #34 Lactose intolerance – Walter Bushnell Healthcare Foundationhttps://wbhf.walterbushnell.com/publications/bush-beats/item/56-lactose-intolerance
In India it has been observed that the frequency and degree of lactose malabsorption is higher in the Southern Indian populations compared to the North which could be attributable to possible genetic differences among these subpopulations. […] Furthermore as mentioned earlier a relationship has been noted between age and lactose malabsorption; as age increases the prevalence of lactose malabsorption shows an increase. […] Considering secondary causes lactose intolerance has been found to be higher in cases with active gastrointestinal etiologies such as ulcerative colitis implicated as cause of secondary lactose intolerance. […] Lactose intolerance is a common problem worldwide that occurs due to deficiency of the gastrointestinal lactase enzyme. The burden of the disease may be typically higher in Asia where most individuals may have some sort of lactase deficiency and are unable to digest lactose present in milk and milk products.
- #35 Lactose Intolerance | Treatment & Management | Point of Carehttps://www.statpearls.com/point-of-care/24003
Lactose intolerance is a common disease; however, it is rare in children younger than 5. It is most often seen in adolescents and young adults. On average, 65% of the world’s population is lactose intolerant. The prevalence of lactose intolerance is variable among different ethnicities. It is most common in African Americans, Hispanics/Latinos, and Asians and least prevalent in people of European descent. Ethnic groups with a higher prevalence of lactose intolerance also are more likely to have lactose non-persistence. […] The primary form is the commonest (found in up to 70% of the world’s population, but not all of them are symptomatic). On the contrary, the congenital type is extremely rare (with around 40 cases reported worldwide to date). […] In the US, the primary disease is much more common in certain ethnicities, such as African-Americans, American Indians, Hispanics or Latinos, and Asian-Americans, than in White Americans. North Americans, Australians, and White Northern Europeans have the lowest rates, ranging between 2% and 15%. On the contrary, the prevalence of lactose intolerance is 50% to 80% in South Americans, around 100% in American Indians and some East Asians, and around 60% to 80% in Ashkenazi Jews and Africans.
- #36 Lactose intolerance – Walter Bushnell Healthcare Foundationhttps://wbhf.walterbushnell.com/publications/bush-beats/item/56-lactose-intolerance
In India it has been observed that the frequency and degree of lactose malabsorption is higher in the Southern Indian populations compared to the North which could be attributable to possible genetic differences among these subpopulations. […] Furthermore as mentioned earlier a relationship has been noted between age and lactose malabsorption; as age increases the prevalence of lactose malabsorption shows an increase. […] Considering secondary causes lactose intolerance has been found to be higher in cases with active gastrointestinal etiologies such as ulcerative colitis implicated as cause of secondary lactose intolerance. […] Lactose intolerance is a common problem worldwide that occurs due to deficiency of the gastrointestinal lactase enzyme. The burden of the disease may be typically higher in Asia where most individuals may have some sort of lactase deficiency and are unable to digest lactose present in milk and milk products.
- #37 Pediatric Lactose Intolerance: Background, Pathophysiology, Etiologyhttps://emedicine.medscape.com/article/930971-overview
Lactase activity is genetically programmed to decline, beginning after age 2 years. […] Signs and symptoms usually do not become apparent until after age 6-7 years, and relatively recent studies have actually shown that hypolactasia may begin even after age 20. […] Secondary lactase deficiency due to intestinal mucosal injury can appear at any age; however, children younger than 2 years are very susceptible because of many factors, including a high sensitivity of the gut to infectious agents, low reserve because of the small intestinal surface area, and high reliance on milk-based products for nutrition.
- #38 Lactose Intolerance (Causes, Symptoms, and Treatment)https://patient.info/doctor/lactose-intolerance-pro
How common is lactose intolerance? (Epidemiology) […] The global prevalence of lactose malabsorption is estimated to be 68%, ranging from 28% in Western, Southern, and Northern Europe, to 70% in the Middle East. […] There is wide geographical and ethnic variation in the age-related decline in lactase levels. This is related to the level of dairy consumption in the diet. […] The prevalence of high lactase levels in adulthood is highest in Northern European populations and lowest in black and East Asiatic communities where, traditionally, the adult diet does not include milk. People who lose lactase activity more quickly after weaning will present earlier with symptoms. […] Chinese and Japanese people lose 80% to 90% of lactase activity within 3 to 4 years after weaning; Jewish and Asian people lose 70% to 80% over several years after weaning; and in white Northern Europeans and North Americans it may take up to 18 to 20 years for lactase to reach its lowest levels.
- #39 Lactose Intolerance: Background, Pathophysiology, Etiologyhttps://emedicine.medscape.com/article/187249-overview
Few data are available regarding the prevalence of lactose intolerance in children aged 1-5 years; however, primary lactose intolerance in this group is estimated to be 0-17.9%, whereas it is a reported 0-19% for secondary lactose intolerance. […] Among adults, the age of presentation of lactose intolerance is 20-40 years.
- #40 Lactose Intolerance Market Size & Share | Forecast – 2035https://www.imarcgroup.com/lactose-intolerance-market
Lactose intolerance is most common in persons of East Asian heritage, with 70 to 100 percent of those affected in these cultures. […] 80 percent of all Native Americans and African-Americans are lactose intolerant. […] Lactose intolerance typically manifests in adults between the ages of 20 and 40. […] What is the number of prevalent cases (2019-2035) of lactose intolerance across the seven major markets? […] What is the size of the lactose intolerance patient pool (2019-2024) across the seven major markets? […] What would be the forecasted patient pool (2025-2035) across the seven major markets? […] What are the key factors driving the epidemiological trend of lactose intolerance? […] What will be the growth rate of patients across the seven major markets?
- #41 Lactose Intolerance | Treatment & Management | Point of Carehttps://www.statpearls.com/point-of-care/24003
The age-related decline in lactase activity is generally complete during childhood; however, the decline has also been seen to occur later, in adolescence, particularly in Whites. The eventual level and the duration of loss of lactase expression vary considerably per ethnicity. […] The onset of the disease is generally subtle and progressive in primary illness, and many patients first experience symptoms of intolerance in late adolescence and adulthood. As opposed to White Northern Europeans, Australians, and North Americans, earlier presentation is noted in Native Americans, Asian-Americans, African-Americans, and Hispanics/Latinos. The secondary disease is commoner in children, particularly in developing countries where infections are a common cause. […] The sexes are affected equally.
- #42 Lactose Intolerance | Treatment & Management | Point of Carehttps://www.statpearls.com/point-of-care/24003
The age-related decline in lactase activity is generally complete during childhood; however, the decline has also been seen to occur later, in adolescence, particularly in Whites. The eventual level and the duration of loss of lactase expression vary considerably per ethnicity. […] The onset of the disease is generally subtle and progressive in primary illness, and many patients first experience symptoms of intolerance in late adolescence and adulthood. As opposed to White Northern Europeans, Australians, and North Americans, earlier presentation is noted in Native Americans, Asian-Americans, African-Americans, and Hispanics/Latinos. The secondary disease is commoner in children, particularly in developing countries where infections are a common cause. […] The sexes are affected equally.
- #43 Lactose intolerance epidemiology and demographics – wikidochttps://www.wikidoc.org/index.php/Lactose_intolerance_epidemiology_and_demographics
The prevalence of lactose intolerance is approximately 75,000 per 100,000 individuals worldwide. […] The prevalence of lactose intolerance is low in children younger than six years. […] Europeans and European Americans individuals are less likely to develop lactose intolerance. […] Lactose intolerance affects men and women equally. […] The majority of lactose intolerance cases are reported in the Far East. […] The prevalence of lactose intolerance is up to 75000 per 100,000 individuals worldwide. […] In North America, the prevalence of lactose intolerance: Native America: 79000 per 100,000 individuals, Black: 75000 per 100,000 individuals, Hispanics: 51000 per 100,000 individuals, Caucasians: 21000 per 100,000 individuals. […] The prevalence of lactose intolerance in Latin America, Africa, and Asia is 15000-100000 per 100,000 individuals.
- #44 Lactose Intolerance: Background, Pathophysiology, Etiologyhttps://emedicine.medscape.com/article/187249-overview
The prevalence of primary lactose intolerance varies according to race. As many as 25% of the white population (prevalence in those from southern European roots) is estimated to have lactose intolerance, while among black, Native American, and Asian American populations, the prevalence of lactose intolerance is estimated at 75-90%. […] An estimated 70-75% off the world’s population is lactose-deficient. Lactose intolerance is very common among Asian, South American, and African persons. […] Lactose intolerance also appears to have a higher prevalence in patients with diarrhea-predominant irritable bowel syndrome (IBS-D) than healthy individuals. […] Persons of all races are affected by lactose intolerance, with a higher prevalence among Asian, African, and South American persons. […] Males and females are equally affected by lactose intolerance. However, of adult women who are lactose intolerant, 44% regain the ability to digest lactose during pregnancy. This is probably due to slow intestinal transit and bacterial adaptation during pregnancy.
- #45 Lactose Intolerance | Treatment & Management | Point of Carehttps://www.statpearls.com/point-of-care/24003
Lactose intolerance is a common disease; however, it is rare in children younger than 5. It is most often seen in adolescents and young adults. On average, 65% of the world’s population is lactose intolerant. The prevalence of lactose intolerance is variable among different ethnicities. It is most common in African Americans, Hispanics/Latinos, and Asians and least prevalent in people of European descent. Ethnic groups with a higher prevalence of lactose intolerance also are more likely to have lactose non-persistence. […] The primary form is the commonest (found in up to 70% of the world’s population, but not all of them are symptomatic). On the contrary, the congenital type is extremely rare (with around 40 cases reported worldwide to date). […] In the US, the primary disease is much more common in certain ethnicities, such as African-Americans, American Indians, Hispanics or Latinos, and Asian-Americans, than in White Americans. North Americans, Australians, and White Northern Europeans have the lowest rates, ranging between 2% and 15%. On the contrary, the prevalence of lactose intolerance is 50% to 80% in South Americans, around 100% in American Indians and some East Asians, and around 60% to 80% in Ashkenazi Jews and Africans.
- #46 Lactose Intolerance | Treatment & Management | Point of Carehttps://www.statpearls.com/point-of-care/24003
Lactose intolerance is a common disease; however, it is rare in children younger than 5. It is most often seen in adolescents and young adults. On average, 65% of the world’s population is lactose intolerant. The prevalence of lactose intolerance is variable among different ethnicities. It is most common in African Americans, Hispanics/Latinos, and Asians and least prevalent in people of European descent. Ethnic groups with a higher prevalence of lactose intolerance also are more likely to have lactose non-persistence. […] The primary form is the commonest (found in up to 70% of the world’s population, but not all of them are symptomatic). On the contrary, the congenital type is extremely rare (with around 40 cases reported worldwide to date). […] In the US, the primary disease is much more common in certain ethnicities, such as African-Americans, American Indians, Hispanics or Latinos, and Asian-Americans, than in White Americans. North Americans, Australians, and White Northern Europeans have the lowest rates, ranging between 2% and 15%. On the contrary, the prevalence of lactose intolerance is 50% to 80% in South Americans, around 100% in American Indians and some East Asians, and around 60% to 80% in Ashkenazi Jews and Africans.
- #47 Pediatric Lactose Intolerance: Background, Pathophysiology, Etiologyhttps://emedicine.medscape.com/article/930971-overview
Lactose intolerance in adulthood is very common and is the result of a genetically programmed progressive loss of the activity of the small intestinal enzyme lactase. […] An estimated 68-70% of the global population has lactose intolerance. […] Adult-onset lactase deficiency varies widely among countries. […] Although as many as 20-25% of White US adults are believed to be lactase deficient, the true prevalence of this condition is unknown, as noted in a comprehensive National Institute of Health (NIH) consensus conference on the topic. […] The prevalence in other racial groups parallels the country of racial origin. […] A systematic review and meta-analysis of the MEDLINE and Embase literature from inception to late 2016 comprising data from 450 study populations (N = 62,910) and 89 countries of individuals at least 10 years old found an estimated 68% global prevalence of lactose malabsorption (standardized for country size).
- #48 Lactose Intolerance | AAFPhttps://www.aafp.org/pubs/afp/issues/2002/0501/p1845.html
Persons with lactose intolerance are unable to digest significant amounts of lactose because of a genetically inadequate amount of the enzyme lactase. […] Lactase deficiency is present in up to 15 percent of persons of northern European descent, up to 80 percent of blacks and Latinos, and up to 100 percent of American Indians and Asians. […] The most common form of lactase deficiency is primary adult hypolactasia. […] However, the prevalence of hypolactasia varies widely among ethnic backgrounds. Estimates range from 2 percent in persons from Northern Europe to nearly 100 percent in adult Asians and American Indians. Blacks and Ashkenazi Jews have prevalences of 60 to 80 percent, and Latinos have a prevalence of 50 to 80 percent. […] The wide variation in prevalence has caused speculation that lactase deficiency is the normal or natural state, and the persistence of significant lactase activity into adult life in northern European populations is an abnormal mutation that provides a selective advantage to groups using dairy products. […] Lactose intolerance is generally a lifelong inherited condition but can be a temporary result of an infection or other insult to the jejunal mucosa. […] Accurate diagnosis of lactose intolerance can significantly relieve patient anxiety and avoid inappropriate investigation and treatment.
- #49 Lactose intolerance | Better Health Channelhttps://www.betterhealth.vic.gov.au/health/conditionsandtreatments/lactose-intolerance
Lactose intolerance is the reduced ability to digest milk sugars, due to insufficient amounts of the gut enzyme called lactase. […] It is rare for Caucasians to develop lactose intolerance. However, a form of lactose intolerance that develops after about 5 years of age is quite common (and normal) among people from Asia, Africa, the Middle East and some Mediterranean countries, as well as among Aboriginal Australians. […] Secondary lactose intolerance is more common. This can occur temporarily after a bout of gastroenteritis, for example, but often improves after several weeks as the lining of the gut heals. […] There are 2 types of lactose intolerance in babies: primary and secondary lactose intolerance. […] Primary lactose intolerance (or congenital lactose intolerance) is a very rare genetic condition.
- #50 Lactose Intolerance | Treatment & Management | Point of Carehttps://www.statpearls.com/point-of-care/24003
The age-related decline in lactase activity is generally complete during childhood; however, the decline has also been seen to occur later, in adolescence, particularly in Whites. The eventual level and the duration of loss of lactase expression vary considerably per ethnicity. […] The onset of the disease is generally subtle and progressive in primary illness, and many patients first experience symptoms of intolerance in late adolescence and adulthood. As opposed to White Northern Europeans, Australians, and North Americans, earlier presentation is noted in Native Americans, Asian-Americans, African-Americans, and Hispanics/Latinos. The secondary disease is commoner in children, particularly in developing countries where infections are a common cause. […] The sexes are affected equally.
- #51 Lactose intolerance epidemiology and demographics – wikidochttps://www.wikidoc.org/index.php/Lactose_intolerance_epidemiology_and_demographics
The prevalence of lactose intolerance is low in children younger than six years. […] The prevalence of lactose intolerance increases with age. […] Lactose intolerance usually affects the following populations: African Americans, Hispanics, Asians, Asian Americans, Native Americans. […] Europeans and European Americans are less likely to develop lactose intolerance. […] Lactose intolerance affects men and women equally. […] The majority of lactose intolerance cases are reported in the Far East. […] Northwestern Europe has the lowest prevalence of lactose intolerance. […] The following countries have the highest rates of lactose intolerance in Africa: Nigeria, Malawi, Sudan, Ethiopia, Uganda. […] The following countries have the lowest rates of lactose intolerance in Africa: Cameroon, Mali, South Africa, Morocco. […] Congenital lactase deficiency is a rare disease that tends to affect Finnish population. […] Secondary lactase deficiency is more common in children, particularly in the developing countries due to high prevalence of infections.
- #52 Lactose intolerance | Causes, Symptoms & Treatment | Britannicahttps://www.britannica.com/science/lactose-intolerance
Lactose intolerance is caused a by deficiency in the amount of lactase, the enzyme that breaks down lactose in the small intestine. […] The incidence varies according to race. For primary lactose intolerance, about 75 to 90 percent of Native Americans, Blacks, Latinos, Asians, Mediterraneans, and Jews can be affected. On the other end, only 5 percent of northern and central European descendants are affected. […] Secondary lactose intolerance can occur at any age, and about 50 percent of infants with diarrhea will be found to have it. […] The diseases causing secondary lactose intolerance include rotavirus, giardia and other parasitic infections, inflammatory bowel disease, celiac disease, cystic fibrosis, and AIDS. […] Diagnosis of lactose intolerance can be done through multiple routes. […] Treatment for lactose intolerance consists primarily of decreasing lactose consumption.
- #53 Lactose intolerance | Causes, Symptoms & Treatment | Britannicahttps://www.britannica.com/science/lactose-intolerance
Lactose intolerance is caused a by deficiency in the amount of lactase, the enzyme that breaks down lactose in the small intestine. […] The incidence varies according to race. For primary lactose intolerance, about 75 to 90 percent of Native Americans, Blacks, Latinos, Asians, Mediterraneans, and Jews can be affected. On the other end, only 5 percent of northern and central European descendants are affected. […] Secondary lactose intolerance can occur at any age, and about 50 percent of infants with diarrhea will be found to have it. […] The diseases causing secondary lactose intolerance include rotavirus, giardia and other parasitic infections, inflammatory bowel disease, celiac disease, cystic fibrosis, and AIDS. […] Diagnosis of lactose intolerance can be done through multiple routes. […] Treatment for lactose intolerance consists primarily of decreasing lactose consumption.
- #54 Lactose Intolerance | Treatment & Management | Point of Carehttps://www.statpearls.com/point-of-care/24003
Lactose intolerance is a common disease; however, it is rare in children younger than 5. It is most often seen in adolescents and young adults. On average, 65% of the world’s population is lactose intolerant. The prevalence of lactose intolerance is variable among different ethnicities. It is most common in African Americans, Hispanics/Latinos, and Asians and least prevalent in people of European descent. Ethnic groups with a higher prevalence of lactose intolerance also are more likely to have lactose non-persistence. […] The primary form is the commonest (found in up to 70% of the world’s population, but not all of them are symptomatic). On the contrary, the congenital type is extremely rare (with around 40 cases reported worldwide to date). […] In the US, the primary disease is much more common in certain ethnicities, such as African-Americans, American Indians, Hispanics or Latinos, and Asian-Americans, than in White Americans. North Americans, Australians, and White Northern Europeans have the lowest rates, ranging between 2% and 15%. On the contrary, the prevalence of lactose intolerance is 50% to 80% in South Americans, around 100% in American Indians and some East Asians, and around 60% to 80% in Ashkenazi Jews and Africans.
- #55 Lactose intolerance epidemiology and demographics – wikidochttps://www.wikidoc.org/index.php/Lactose_intolerance_epidemiology_and_demographics
The prevalence of lactose intolerance is low in children younger than six years. […] The prevalence of lactose intolerance increases with age. […] Lactose intolerance usually affects the following populations: African Americans, Hispanics, Asians, Asian Americans, Native Americans. […] Europeans and European Americans are less likely to develop lactose intolerance. […] Lactose intolerance affects men and women equally. […] The majority of lactose intolerance cases are reported in the Far East. […] Northwestern Europe has the lowest prevalence of lactose intolerance. […] The following countries have the highest rates of lactose intolerance in Africa: Nigeria, Malawi, Sudan, Ethiopia, Uganda. […] The following countries have the lowest rates of lactose intolerance in Africa: Cameroon, Mali, South Africa, Morocco. […] Congenital lactase deficiency is a rare disease that tends to affect Finnish population. […] Secondary lactase deficiency is more common in children, particularly in the developing countries due to high prevalence of infections.
- #56 Lactose intolerance | Better Health Channelhttps://www.betterhealth.vic.gov.au/health/conditionsandtreatments/lactose-intolerance
Lactose intolerance is the reduced ability to digest milk sugars, due to insufficient amounts of the gut enzyme called lactase. […] It is rare for Caucasians to develop lactose intolerance. However, a form of lactose intolerance that develops after about 5 years of age is quite common (and normal) among people from Asia, Africa, the Middle East and some Mediterranean countries, as well as among Aboriginal Australians. […] Secondary lactose intolerance is more common. This can occur temporarily after a bout of gastroenteritis, for example, but often improves after several weeks as the lining of the gut heals. […] There are 2 types of lactose intolerance in babies: primary and secondary lactose intolerance. […] Primary lactose intolerance (or congenital lactose intolerance) is a very rare genetic condition.
- #57 Lactose Intolerance: Background, Pathophysiology, Etiologyhttps://emedicine.medscape.com/article/187249-overview
The prevalence of primary lactose intolerance varies according to race. As many as 25% of the white population (prevalence in those from southern European roots) is estimated to have lactose intolerance, while among black, Native American, and Asian American populations, the prevalence of lactose intolerance is estimated at 75-90%. […] An estimated 70-75% off the world’s population is lactose-deficient. Lactose intolerance is very common among Asian, South American, and African persons. […] Lactose intolerance also appears to have a higher prevalence in patients with diarrhea-predominant irritable bowel syndrome (IBS-D) than healthy individuals. […] Persons of all races are affected by lactose intolerance, with a higher prevalence among Asian, African, and South American persons. […] Males and females are equally affected by lactose intolerance. However, of adult women who are lactose intolerant, 44% regain the ability to digest lactose during pregnancy. This is probably due to slow intestinal transit and bacterial adaptation during pregnancy.
- #58 The importance of lactose intolerance in individuals with gastrointestinal symptoms | Revista de GastroenterologÃa de Méxicohttps://www.revistagastroenterologiamexico.org/en-the-importance-lactose-intolerance-in-articulo-S2255534X20300426
Studies in Mexico found that almost half the adult population complained of gastrointestinal discomfort related to the consumption of dairy products, and of those, 70% had a positive test, suggesting deficient lactose digestion. […] The symptoms attributed to LI are due to the osmotic property of lactose that attracts water from the intravascular space to the intestinal lumen and partially depends on the speed at which the disaccharide arrives at the intestine, in turn, reflecting the quantity of lactose that was not hydrolyzed. […] LNP does not appear to be associated with other digestive diseases, even though individuals with irritable bowel syndrome have been shown to have a greater probability of presenting with LI than the general population. […] LI and deficient lactose digestion are frequent in Mexico. It is an over-diagnosed condition, with symptoms that are easily confused with other digestive tract problems, often leading to a poorly substantiated recommendation to stop milk and dairy product consumption.
- #59 Lactose intolerance – Walter Bushnell Healthcare Foundationhttps://wbhf.walterbushnell.com/publications/bush-beats/item/56-lactose-intolerance
In India it has been observed that the frequency and degree of lactose malabsorption is higher in the Southern Indian populations compared to the North which could be attributable to possible genetic differences among these subpopulations. […] Furthermore as mentioned earlier a relationship has been noted between age and lactose malabsorption; as age increases the prevalence of lactose malabsorption shows an increase. […] Considering secondary causes lactose intolerance has been found to be higher in cases with active gastrointestinal etiologies such as ulcerative colitis implicated as cause of secondary lactose intolerance. […] Lactose intolerance is a common problem worldwide that occurs due to deficiency of the gastrointestinal lactase enzyme. The burden of the disease may be typically higher in Asia where most individuals may have some sort of lactase deficiency and are unable to digest lactose present in milk and milk products.
- #60 Lactose Intolerance | AAFPhttps://www.aafp.org/pubs/afp/issues/2002/0501/p1845.html
Persons with lactose intolerance are unable to digest significant amounts of lactose because of a genetically inadequate amount of the enzyme lactase. […] Lactase deficiency is present in up to 15 percent of persons of northern European descent, up to 80 percent of blacks and Latinos, and up to 100 percent of American Indians and Asians. […] The most common form of lactase deficiency is primary adult hypolactasia. […] However, the prevalence of hypolactasia varies widely among ethnic backgrounds. Estimates range from 2 percent in persons from Northern Europe to nearly 100 percent in adult Asians and American Indians. Blacks and Ashkenazi Jews have prevalences of 60 to 80 percent, and Latinos have a prevalence of 50 to 80 percent. […] The wide variation in prevalence has caused speculation that lactase deficiency is the normal or natural state, and the persistence of significant lactase activity into adult life in northern European populations is an abnormal mutation that provides a selective advantage to groups using dairy products. […] Lactose intolerance is generally a lifelong inherited condition but can be a temporary result of an infection or other insult to the jejunal mucosa. […] Accurate diagnosis of lactose intolerance can significantly relieve patient anxiety and avoid inappropriate investigation and treatment.
- #61 Lactose intolerance | Causes, Symptoms & Treatment | Britannicahttps://www.britannica.com/science/lactose-intolerance
Lactose intolerance is caused a by deficiency in the amount of lactase, the enzyme that breaks down lactose in the small intestine. […] The incidence varies according to race. For primary lactose intolerance, about 75 to 90 percent of Native Americans, Blacks, Latinos, Asians, Mediterraneans, and Jews can be affected. On the other end, only 5 percent of northern and central European descendants are affected. […] Secondary lactose intolerance can occur at any age, and about 50 percent of infants with diarrhea will be found to have it. […] The diseases causing secondary lactose intolerance include rotavirus, giardia and other parasitic infections, inflammatory bowel disease, celiac disease, cystic fibrosis, and AIDS. […] Diagnosis of lactose intolerance can be done through multiple routes. […] Treatment for lactose intolerance consists primarily of decreasing lactose consumption.
- #62 Lactose intolerance | Better Health Channelhttps://www.betterhealth.vic.gov.au/health/conditionsandtreatments/lactose-intolerance
Secondary lactose intolerance occurs when the gut lining (where lactase is produced) is damaged. […] Various methods may be used to diagnose lactose intolerance, including: Hydrogen breath test this tests the amount of hydrogen that is breathed out. […] Most people with lactose intolerance can handle small amounts of lactose, such as a glass of milk, which contains 8 to 10 grams of lactose. […] Foods that may contain hidden lactose include: biscuits and cakes (if milk or milk solids are added), processed breakfast cereals, cheese sauce, cream soups, custard, milk chocolate, pancakes and pikelets, scrambled eggs, quiche, muesli bars, some breads and margarine (containing milk). […] If you are trying to avoid lactose, ingredients to look for in lists on food labels include: milk solids, non-fat milk solids, whey, milk sugar.
- #63 :: CNR :: Clinical Nutrition Researchhttps://e-cnr.org/DOIx.php?id=10.7762/cnr.2025.14.1.30
Lactose intolerance is characterized by gastrointestinal symptoms such as abdominal bloating, pain, and diarrhea after consuming lactose-containing foods or beverages. Approximately 65% of the global population is estimated to have lactose intolerance, with its prevalence varying depending on ethnicity. It is less common among individuals of European descent but more prevalent among African Americans, Hispanics, and Asians. Lactose intolerance is particularly common in East Asia, with a reported prevalence of 70% in South Korea. The most commonly used diagnostic method for lactose intolerance is the hydrogen breath test. This test leverages the normal gut microbiota, metabolizing lactose into hydrogen and short-chain fatty acids (SCFAs). Hydrogen is absorbed and enters the systemic circulation via the liver, eventually exhaled through the lungs. An increase of more than 20 ppm in breath hydrogen levels compared to the baseline after lactose ingestion indicates lactose intolerance.
- #64https://journals.lww.com/co-clinicalnutrition/fulltext/2024/07000/lactose_malabsorption_and_intolerance_in_older.5.aspx
The most common test for diagnosing lactose malabsorption is the hydrogen breath test (HBT). The rationale of this investigation is based on detection of hydrogen in pulmonary expired air produced from the fermentation of undigested lactose by the colonic microflora. Although HBT represents the most common diagnostic test for diagnosis of lactose malabsorption, it can also lead to false-positive results, linked to an increased H2 production due to a condition of small intestinal bacterial overgrowth, and false-negative results, for example, in no H2 producers. […] Despite growing knowledge on lactose malabsorption and intolerance, correct approach to these conditions, including their diagnostic assessment, remains a matter of debate, especially in older adults. Few studies have been conducted to establish possible age-related differences in lactose metabolism. However, no definitive conclusions or recommendations for clinical practice are available on the subject.
- #65 Quick Facts:Lactose Intolerance – Merck Manual Consumer Versionhttps://www.merckmanuals.com/home/quick-facts-digestive-disorders/malabsorption/lactose-intolerance
Lactose intolerance is very common […] Lactose intolerance can also start after you have an injury or surgery on your intestines or have another bowel problem. […] Doctors will have you stop eating or drinking dairy for a while. If your symptoms stop and then return when you eat dairy again, you probably have lactose intolerance. […] People who must avoid dairy products may need calcium supplements to prevent calcium deficiency.
- #66https://bpac.org.nz/2021/lactose-intolerance.aspx
Primary lactase deficiency, the main cause of lactose intolerance, is estimated to affect 8% of people in New Zealand, with substantially higher rates among Mori, Pacific and southeast Asian peoples. […] Lactose intolerance can usually be diagnosed through dietary challenge, i.e. the return of symptoms following reintroduction of milk and milk products after an elimination period. […] The prevalence of lactose intolerance is more difficult to estimate than lactose malabsorption as studies mainly rely on self-reported symptoms during a lactose challenge, which are rarely blinded; self-reported lactose intolerance has a sensitivity of 30 71% and specificity of 25 87%. […] Of the limited New Zealand data available, an increased prevalence of lactose malabsorption in Mori and Pacific peoples has been observed compared to New Zealand Europeans, based on breath hydrogen testing.
- #67 Kansas City Lactose Intolerance Doctors in Lee’s Summit MOhttps://www.midwestgihealth.com/kansas-city-lactose-intolerance-doctors
Lactose intolerance is the inability to digest significant amounts of lactose, the predominant sugar of milk. […] Between 30 and 50 million Americans are lactose intolerant. Certain ethnic and racial populations are more widely affected than others. As many as 75 percent of all African Americans and American Indians and 90 percent of Asian Americans are lactose intolerant. The condition is least common among persons of northern European descent. […] Researchers have identified a genetic variation associated with lactose intolerance; this discovery may be useful in developing a diagnostic test to identify people with this condition.
- #68https://bpac.org.nz/2021/lactose-intolerance.aspx
A study conducted in Christchurch in 2010 found that the overall prevalence of primary lactose intolerance determined by genetic testing was 8% (among 1,064 participants); of the 30 Mori and Pacific participants, the prevalence was 30%. […] Lactose intolerance is initially treated by minimising or avoiding lactose-containing foods, however, most people can eventually tolerate one to two glasses of milk daily, if consumed in small portions with food. […] People with primary lactase deficiency should be encouraged to gradually and regularly increase their intake of lactose-containing foods until a level of tolerance is achieved. […] Lactose intolerance is not a cows milk protein allergy, which is an immune-mediated reaction, often distinguished by more severe gastrointestinal symptoms (including rectal bleeding), eczema and urticaria; it is managed by removal of all dairy products from the diet.
- #69 Lactose Intolerance – Harvard Healthhttps://www.health.harvard.edu/a_to_z/lactose-intolerance-a-to-z
Lactose intolerance usually is genetic (inherited). In many people of African or Asian descent, the body begins making less lactase around age 5. As many as 90% of people from some areas of Eastern Asia, 80% of American Indians, 65% of Africans and African-Americans, and 50% of Hispanics have some degree of lactose intolerance. In contrast, most Caucasians (80%) have a gene that preserves the ability to produce lactase into adulthood. […] A significant number of people who have symptoms that suggest lactose intolerance will have normal results on diagnostic tests. […] People who develop lactose intolerance as a result of gastroenteritis or another insult to digestion can recover completely when the intestinal problem is treated. This may take several weeks to months. […] When lactose intolerance is genetic, the condition is permanent. However, people can avoid symptoms by avoiding foods that contain lactose (essentially, dairy products) or by eating them in moderation. […] There is no way to prevent lactose intolerance. […] The outlook for people with lactose intolerance is excellent. Symptoms can be alleviated if dairy products are limited or avoided, or if they are eaten along with a dose of commercially prepared lactase enzyme.
- #70https://journals.lww.com/co-clinicalnutrition/fulltext/2024/07000/lactose_malabsorption_and_intolerance_in_older.5.aspx
The most common test for diagnosing lactose malabsorption is the hydrogen breath test (HBT). The rationale of this investigation is based on detection of hydrogen in pulmonary expired air produced from the fermentation of undigested lactose by the colonic microflora. Although HBT represents the most common diagnostic test for diagnosis of lactose malabsorption, it can also lead to false-positive results, linked to an increased H2 production due to a condition of small intestinal bacterial overgrowth, and false-negative results, for example, in no H2 producers. […] Despite growing knowledge on lactose malabsorption and intolerance, correct approach to these conditions, including their diagnostic assessment, remains a matter of debate, especially in older adults. Few studies have been conducted to establish possible age-related differences in lactose metabolism. However, no definitive conclusions or recommendations for clinical practice are available on the subject.
- #71https://journals.lww.com/co-clinicalnutrition/fulltext/2024/07000/lactose_malabsorption_and_intolerance_in_older.5.aspx
Lactose malabsorption and intolerance are very common conditions. However, their optimal approach, including the diagnostic assessment, remains a matter of debate, especially in advanced age. Older adults are at high risk of malnutrition, owing to frequent occurrence of cognitive impairment, loss of appetite, dysphagia, and poor oral health. Testing for lactose malabsorption may be challenging in older adults, if not useless. Instead, a detailed clinical evaluation should always be pursued to identify both lactose intolerance and all confounding factors mimicking the same clinical picture. […] Lactose malabsorption consists in a reduced absorption of lactose in the intestinal tract because of different causes, whereas lactose intolerance is characterized by the occurrence of gastrointestinal symptoms resulting from colonic fermentation of undigested lactose. It has been estimated that lactose malabsorption occurs in around two-thirds of the world’s population, with a wide variation in prevalence among countries and regions, ranging from 28% in Western, Southern, and Northern Europe to 70% in the Middle East. However, these percentages may underestimate or overestimate the real prevalence, since the lack of a gold standard for diagnosis. In general, the frequency of lactose malabsorption increases with age, mainly in populations with a high prevalence.
- #72https://journals.lww.com/co-clinicalnutrition/fulltext/2024/07000/lactose_malabsorption_and_intolerance_in_older.5.aspx
The mechanisms underlying the higher prevalence of lactose malabsorption in old age are not completely clear. It has been suggested that this phenomenon may result from the aging gut process, characterized by elevated enterocyte turnover with consequent increased percentage of immature villous epithelial cells with reduced lactase expression. […] The management of lactose malabsorption and intolerance in older adults deserves a personalized approach. Because of the importance of maintaining an adequate nutritional status in this population, efforts should be made to avoid overly restrictive diets. Obtaining a lactose HBT may be unnecessary in most cases of suspected lactose intolerance, also considering the low reliability of the test in older adults and the high rate of false-positive results.
- #73 The importance of lactose intolerance in individuals with gastrointestinal symptoms | Revista de GastroenterologÃa de Méxicohttps://www.revistagastroenterologiamexico.org/en-the-importance-lactose-intolerance-in-articulo-S2255534X20300426
Lactose intolerance is a condition with an elevated prevalence worldwide, especially in Latin American, Asian, and African countries. […] The aim of the present narrative review was to highlight the importance of accurately diagnosing lactose intolerance to prevent self-diagnosis that results in the unnecessary elimination of milk and dairy products from the diet and the consequent deprivation of nutrients that could be essential at certain stages of life. […] Lactose intolerance consists of a set of symptoms attributed to the consumption of milk and dairy products that are assumed to be due to deficient digestion of that disaccharide. […] LI is a frequent condition worldwide. There are European, American, Asian, and African case series that describe a varied prevalence of 15%, 50%, 70%, and 100%, respectively.
- #74 Perception of lactose intolerance impairs health-related quality of life | European Journal of Clinical Nutritionhttps://www.nature.com/articles/ejcn201680
Chronic conditions impair perception of well-being. Malabsorption of lactose is the most frequent form of malabsorption and manifests as lactose intolerance. There is a lack of information regarding their impact on self-perception of health. The objective of this study is to determine the subjective impact of self-reported lactose intolerance or objective lactose malabsorption on patient health by using a patient-reported outcome to measure health-related quality of life (HRQOL) and modification of lactose-containing food diet. […] A total of 580 patients were included (median age 30 years, 419 female). Overall, 324 patients (56%) considered themselves lactose intolerant and that perception was associated with avoidance of dairy consumption (55% vs only 9% of self-defined tolerants). Self-perception of intolerance was associated with lower HRQOL scores (median, 60 vs 70, P0.01). In contrast, lactose objective malabsorption was not clearly associated with dairy avoidance (41% of malabsorbers avoided dairy vs 31% of absorbers). However, HRQOL scores were also significantly lower in malabsorbers than in absorbers (60 vs 70 respectively, P0.001). […] Subjective perception of lactose intolerance affects the decision to avoid dairy even more than objective malabsorption. However, both self-perception of lactose intolerance and objective lactose malabsorption are associated with poorer perceived quality of life.
- #75 Lactose intolerance Information | Mount Sinai – New Yorkhttps://www.mountsinai.org/health-library/diseases-conditions/lactose-intolerance
Lactose intolerance is very common in adults. It is rarely dangerous. About 30 million American adults have some degree of lactose intolerance by age 20. […] The condition is very common among adults with Asian, African, or Native American heritage. […] It is less common in people of northern or western European background, but still may occur.
- #76 Lactose intolerance: What happens if someone ignores it?https://www.medicalnewstoday.com/articles/what-happens-if-you-ignore-lactose-intolerance
Lactose intolerance, which results from the inability to break down lactose properly, may develop in childhood or early adulthood. […] Lactose intolerance is a condition that causes symptoms when someone eats or drinks products that contain lactose. […] If someone with a lactose intolerance continues to consume too much lactose, they may experience worsened symptoms, lower mood, and a reduced quality of life. […] People who ignore their lactose intolerance and continue to eat too many dairy products risk exacerbating their symptoms and developing further health complications. […] Lactose intolerance symptoms may affect a person’s quality of life and mood.
- #77 Lactose intolerance: What happens if someone ignores it?https://www.medicalnewstoday.com/articles/what-happens-if-you-ignore-lactose-intolerance
Lactose intolerance, which results from the inability to break down lactose properly, may develop in childhood or early adulthood. […] Lactose intolerance is a condition that causes symptoms when someone eats or drinks products that contain lactose. […] If someone with a lactose intolerance continues to consume too much lactose, they may experience worsened symptoms, lower mood, and a reduced quality of life. […] People who ignore their lactose intolerance and continue to eat too many dairy products risk exacerbating their symptoms and developing further health complications. […] Lactose intolerance symptoms may affect a person’s quality of life and mood.
- #78 Lactose intolerance: What happens if someone ignores it?https://www.medicalnewstoday.com/articles/what-happens-if-you-ignore-lactose-intolerance
Lactose intolerance, which results from the inability to break down lactose properly, may develop in childhood or early adulthood. […] Lactose intolerance is a condition that causes symptoms when someone eats or drinks products that contain lactose. […] If someone with a lactose intolerance continues to consume too much lactose, they may experience worsened symptoms, lower mood, and a reduced quality of life. […] People who ignore their lactose intolerance and continue to eat too many dairy products risk exacerbating their symptoms and developing further health complications. […] Lactose intolerance symptoms may affect a person’s quality of life and mood.
- #79 Lactose intolerance | NHS informhttps://www.nhsinform.scot/illnesses-and-conditions/nutritional/lactose-intolerance/
Lactose intolerance is a common digestive problem where the body is unable to digest lactose, a type of sugar mainly found in milk and dairy products. […] In the UK, lactose intolerance is more common in people of Asian or African-Caribbean descent. […] Lactose intolerance can develop at any age. Many cases first develop in people aged 20 to 40, although babies and young children can also be affected. […] If you are lactose intolerant, getting the right amount of important vitamins and minerals can prove difficult. This may lead to unhealthy weight loss and put you at increased risk of developing the following conditions: Osteopenia where you have a very low bone-mineral density. If osteopenia is not treated, it can develop into osteoporosis. […] Osteoporosis where your bones become thin and weak. If you have osteoporosis, your risk of getting fractures and broken bones is increased. […] Malnutrition when the food you eat does not give you the nutrients essential for a healthy functioning body. If you are malnourished, wounds can take longer to heal and you may start to feel tired or depressed.
- #80 Lactose intolerancehttps://womenshealth.gov/healthy-eating/food-allergies-and-sensitivities/lactose-intolerance
Lactose intolerance is common, but it may be especially harmful for women, as it may raise a woman’s risk for health problems such as osteoporosis. […] Between 30 million and 50 million Americans are lactose-intolerant. […] Lactose intolerance may prevent you from getting enough calcium and vitamin D, which are important for bone health. […] Women especially need to get enough calcium and vitamin D throughout life to help build and maintain bone density and reduce the risk of osteoporosis later in life. […] More women than men are at risk for osteoporosis. […] If you are lactose-intolerant, your doctor or nurse will likely talk to you about how to get more calcium and vitamin D each day.
- #81 Navigating Lactose Intolerance: Unveiling Its Impact on Digestive Health and Uncovering Hidden Sources – Canadian Digestive Health Foundationhttps://cdhf.ca/en/navigating-lactose-intolerance-unveiling-its-impact-on-digestive-health-and-uncovering-hidden-sources/
The World Gastroenterology Organization estimates that between 57% to 65% of the worldâs population has difficulty digesting lactose, the natural sugar in dairy products. […] Most humans are born with the ability to produce lactase; however, some ethnicities, genetics, and dietary factors lead to a decrease in lactase production, preventing the breakdown of lactose. This is often referred to as primary lactase deficiency. […] Alternatively, secondary lactase deficiency can occur when lactase enzyme production decreases or lacks due to disease, illness, or injury to the small intestine. […] When lactose is not properly digested, it can significantly impact gut health in various ways, including gut microbiome disruption, digestive discomfort, and nutritional deficiencies. […] Lactose malabsorption leads to the growth of lactose-fermenting bacteria such as Bifidobacterium and Lactobacillus.
- #82 :: CNR :: Clinical Nutrition Researchhttps://e-cnr.org/DOIx.php?id=10.7762/cnr.2025.14.1.30
Reduced milk consumption can lead to nutritional deficiencies. According to the Korea National Health and Nutrition Survey, the intake of riboflavin, calcium, phosphorus, and potassium significantly differs depending on the frequency of milk consumption. […] This study aimed to evaluate changes in hydrogen breath test results, gastrointestinal symptoms, and nutritional improvements in Korean adults diagnosed with lactose intolerance when low-lactose processed milk was incorporated into their usual diet. […] This study suggests that the removal of lactose and dairy products is not necessary for individuals with lactose intolerance. Incorporating low-lactose processed milk into their usual diet might be a practical dietary management strategy. […] In conclusion, the continuous consumption of low-lactose processed milk containing a tolerable amount of lactose that does not induce gastrointestinal symptoms in individuals with lactose intolerance can reduce exhaled hydrogen levels and mitigate lactose intolerance symptoms. Furthermore, it can enhance the intake of essential nutrients, including animal proteins and calcium, that are often absent in such individuals. This study suggests that lactose intolerance management does not necessarily require the extreme elimination of lactose and dairy products. Instead, improvements can be achieved by incorporating low-lactose processed milk into the regular diet, thereby highlighting a practical and accessible dietary approach.
- #83 Navigating Lactose Intolerance: Unveiling Its Impact on Digestive Health and Uncovering Hidden Sources – Canadian Digestive Health Foundationhttps://cdhf.ca/en/navigating-lactose-intolerance-unveiling-its-impact-on-digestive-health-and-uncovering-hidden-sources/
This disruption causes immediate discomfort and can lead to longer-term imbalances in the gut microbiome, worsening other digestive problems and affecting overall gut health. […] For those with lactose intolerance, the first step in management typically involves reducing or eliminating lactose-containing foods from the diet. […] Many do not realize that this can negatively impact digestive health and lead to a lack of essential dietary nutrients. […] Dairy products are significant sources of essential nutrients such as calcium, vitamin D, phosphorus, and vitamin B12, vital for bone health. […] Notably, lactose-free products are formulated to provide the same nutritional content as traditional dairy products, ensuring that individuals with lactose intolerance can still receive essential nutrients without experiencing digestive discomfort.
- #84 Quick Facts:Lactose Intolerance – Merck Manual Consumer Versionhttps://www.merckmanuals.com/home/quick-facts-digestive-disorders/malabsorption/lactose-intolerance
Lactose intolerance is very common […] Lactose intolerance can also start after you have an injury or surgery on your intestines or have another bowel problem. […] Doctors will have you stop eating or drinking dairy for a while. If your symptoms stop and then return when you eat dairy again, you probably have lactose intolerance. […] People who must avoid dairy products may need calcium supplements to prevent calcium deficiency.
- #85 Navigating Lactose Intolerance: Unveiling Its Impact on Digestive Health and Uncovering Hidden Sources – Canadian Digestive Health Foundationhttps://cdhf.ca/en/navigating-lactose-intolerance-unveiling-its-impact-on-digestive-health-and-uncovering-hidden-sources/
This disruption causes immediate discomfort and can lead to longer-term imbalances in the gut microbiome, worsening other digestive problems and affecting overall gut health. […] For those with lactose intolerance, the first step in management typically involves reducing or eliminating lactose-containing foods from the diet. […] Many do not realize that this can negatively impact digestive health and lead to a lack of essential dietary nutrients. […] Dairy products are significant sources of essential nutrients such as calcium, vitamin D, phosphorus, and vitamin B12, vital for bone health. […] Notably, lactose-free products are formulated to provide the same nutritional content as traditional dairy products, ensuring that individuals with lactose intolerance can still receive essential nutrients without experiencing digestive discomfort.