Materiały źródłowe

• #1 Trigeminal Neuralgia – StatPearls – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK554486/

  Trigeminal neuralgia affects 4 to 13 per 100,000 people annually. Women are more commonly affected than men. The female-to-male prevalence ratio ranges from 1.5 to 1.7 to 1. Most cases of trigeminal neuralgia occur after age 50, but the disease may be seen in the second and third decades of life; trigeminal neuralgia is rarely diagnosed in childhood. The lifetime prevalence of trigeminal neuralgia in population-based studies is estimated at 0.16% to 0.3%. […] The prevalence of trigeminal neuralgia in patients with multiple sclerosis is between 1% and 6.3%. Patients with hypertension have a slightly higher incidence of trigeminal neuralgia than normotensive persons.

• #2 Epidemiology of trigeminal neuralgia: an electronic population health data study in Korea

  https://pmc.ncbi.nlm.nih.gov/articles/PMC8255158/

  Trigeminal neuralgia (TN) is one of the most painful disorder in the orofacial region, and many patients have suffered from this disease. […] Thus, this study was performed to clarify the epidemiological characteristics of TN in the Korean population. This is the first national study to investigate the prevalence of TN in Korean patients. […] The incidence of TN was 100.21 per 100,000 person-years in the year of 2018 in Korea, and the male to female ratio was 12.14. The age group of 51-59 years had the highest prevalence of TN. […] The results in this study will not only help to study the characteristics of TN, but also serve as an important basis for the effective management of TN in Korea. […] In the present study, the prevalence of TN was 100.25 per 100,000 person-years in 2018, with the highest prevalence rate in both sexes in the age group of 51-59 years.

• #3 Burden of illness of trigeminal neuralgia among patients managed in a specialist center in England | The Journal of Headache and Pain | Full Text

  https://thejournalofheadacheandpain.biomedcentral.com/articles/10.1186/s10194-020-01198-z

  Trigeminal neuralgia (TN) is a rare condition that affects the trigeminal nerve, resulting in extreme, sporadic, sudden, electric shock-like unilateral facial pain. The condition occurs most frequently in people over 50 years of age, and is more prevalent in women than in men. The intensity and unpredictability of the pain can be physically and mentally incapacitating, and result in a severe burden of illness (BOI) and impaired patient quality of life (QoL). […] The current study is a cross-sectional component of a longitudinal survey project, and consists of assessments performed at a single timepoint, in a cohort of patients receiving a high level of clinical care at a specialist facility which has been managing TN patients over several years using a multidisciplinary care pathway. […] This cross-sectional study, conducted at a specialist facial pain treatment facility, consisted of a subpopulation of patients of an earlier study. The study yielded several key findings. Overall, the results indicate that a multidisciplinary care pathway can produce substantial benefit in a majority of patients, as evidenced by 79% of patients reporting improvement in the PGIC measure since beginning of treatment at this clinic.

• #4 Trigeminal Neuralgia: Practice Essentials, Background, Anatomy

  https://emedicine.medscape.com/article/794402-overview

  Trigeminal neuralgia has an incidence of 4 to 29 cases per 100,000 person-years, according to population studies in the US and UK. This corresponds to approximately 12,000 to 87,000 new cases diagnosed annually in the US. The condition is more common in females, with a female-to-male ratio of 3:2, and its prevalence increases with age, with a mean onset between 53 and 57 years. Patients who present with the disease when aged 20-40 years are more likely to suffer from a demyelinating lesion in the pons secondary to multiple sclerosis; younger patients also tend to have symptomatic or secondary trigeminal neuralgia. There have also been occasional reports of pediatric cases of trigeminal neuralgia. The estimated lifetime prevalence ranges from 0.16% to 0.3%. Approximately 1% of patients with multiple sclerosis develop trigeminal neuralgia, whereas 2% of patients with trigeminal neuralgia have multiple sclerosis. Patients with both conditions often have bilateral trigeminal neuralgia.

• #5 Trigeminal neuralgia | MedLink Neurology

  https://www.medlink.com/articles/trigeminal-neuralgia

  Trigeminal neuralgia is a rare condition. The prevalence is estimated to be 0.03% to 0.3%, similar to multiple sclerosis and Parkinson disease. Incidence is estimated to be 4.3 to 8 per 100,000. One observational study in central Sweden reported an incidence of 5.5 cases per 100,000 person-years. It is more prevalent in women and in people over 60 years of age. Epidemiological studies suggest incidence increases with age, from 16.3 for patients in their 40s compared to 30.6 for patients older than 80 years. […] The etiology of classical trigeminal neuralgia is attributed to demyelination of the trigeminal afferent pathway in the dorsal root entry zone, which is thought to lead to discharges of the nerve spontaneously or in response to a normally innocuous afferent stimulus. Neurovascular compression, typically by a redundant or tortuous loop of the superior cerebellar artery, is thought to cause that demyelination. A space-occupying lesion can compress the trigeminal nerve root and produce similar symptomatology. MRI may reveal neurovascular contact of the trigeminal nerve root, but this can also be seen in asymptomatic patients, so it is not diagnostic. To convincingly be diagnosed with classical trigeminal neuralgia, there should be evidence of nerve atrophy or displacement, which has a specificity of 97% (100% if at the root entry zone). It is important to note that the presence of nerve compression does not mean trigeminal neuralgia symptoms will occur, as one study found that 92 of 100 asymptomatic cases reviewed were found to have a vessel compressing the trigeminal nerve. A 2024 meta-analysis of 13 observational studies across 1770 nerves (728 symptomatic and 1042 asymptomatic) found a significant difference between the symptomatic and asymptomatic trigeminal nerves, with 53.2% having morphological changes like atrophy, dislocation, distortion, flattening, or indentation compared to 7.9% on the asymptomatic side. Demyelination due to multiple sclerosis can lead to trigeminal neuralgia symptoms, and trigeminal neuralgia has a higher incidence in patients with multiple sclerosis. […]

• #6 Trigeminal Neuralgia | SpringerLink

  https://link.springer.com/chapter/10.1007/978-981-15-1346-6_26

  85% of cases of Trigeminal Neuralgia are of the classic type known as Classical Trigeminal Neuralgia (CTN), while the remaining cases can be separated to secondary Trigeminal Neuralgia (STN). […] STN is thought to be initiated by multiple sclerosis or a space-occupying lesion affecting the trigeminal nerve, whereas the leading cause of CTN is known to be compression of the trigeminal nerve in the region of the dorsal root entry zone by a blood vessel. […] The management of TN patients should be carried out in a multidisciplinary setting to allow the patients to choose the best-suited option for them. […] A systematic review highlighted that the range of TN prevalence was 0.030.3%, mostly women were affected, and the affected age range was 3767 years old. […] NICE guideline data and studies indicate that a survey carried out within general practice in the United Kingdom, which highlighted that the annual incidence of trigeminal neuralgia was 8 per 10,000. […] The true prevalence of this condition remains unclear as there is little data to support the evidence of how common this condition is.

• #7 Pulsenotes | Trigeminal neuralgia notes

  https://app.pulsenotes.com/medicine/neurology/notes/trigeminal-neuralgia

  Trigeminal neuralgia is a rare condition that is more common in women. […] The exact incidence of trigeminal is unclear. Annual incidence in the UK is estimated to be 8 per 10,000 although due to its rarity these estimations can vary wildly. It is around twice as common in women compared to men.

• #8 Epidemiology of trigeminal neuralgia: an electronic population health data study in Korea

  https://www.epain.org/journal/view.html?volume=34&number=3&spage=332

  Epidemiology of trigeminal neuralgia: an electronic population health data study in Korea […] Background: Trigeminal neuralgia (TN) is one of the most painful disorder in the orofacial region, and many patients have suffered from this disease. For the effective management of TN, fundamental epidemiologic data related to the target population group are essential. Thus, this study was performed to clarify the epidemiological characteristics of TN in the Korean population. This is the first national study to investigate the prevalence of TN in Korean patients. […] Methods: From 2014 to 2018, population-based medical data for 51,276,314 subscribers to the National Health Insurance Service of Korea were used for this study. […] Results: The incidence of TN was 100.21 per 100,000 person-years in the year of 2018 in Korea, and the male to female ratio was 1:2.14. The age group of 51-59 years had the highest prevalence of TN. Constant increases in medical cost, regional imbalance, and differences in prescription patterns by the medical specialties were showed in the management of TN.

• #9 Epidemiology | SpringerLink

  https://link.springer.com/chapter/10.1007/978-3-030-60687-9_3

  Trigeminal Neuralgia is considered a rare facial pain syndrome with prevalence rates ranging between 0.03% and 0.3%. It is more commonly seen in females during their fourth, fifth, or sixth decades of life. […] It is important to use standard nomenclature and diagnostic criterias to accurately ascertain true prevalence and incidence rates of a disease; International classification of headache disorder (ICHD) provides a framework for the same. […] Prevalence of trigeminal neuralgia: a systematic review. 2016. […] Epidemiology and clinical features of idiopathic trigeminal neuralgia and glossopharyngeal neuralgia: similarities and differences, Rochester, Minnesota, 1945-1984.

• #10 Diagnosis and treatment of trigeminal neuralgia: Consensus statement from the Spanish Society of Neurology’s Headache Study Group | Neurología (English Edition)

  https://www.elsevier.es/es-revista-neurologia-english-edition–495-articulo-diagnosis-treatment-trigeminal-neuralgia-consensus-S2173580823000275

  Epidemiological studies are scarce, and generally include small samples. The prevalence of TN is estimated at 0.3%, with an incidence rate of 12.6 cases/100 000 person-years. Incidence increases with age, with rates of 17.5 cases/100 000 person-years in the population aged 60-69 years and 25.6 cases among those aged 70 years and older. Mean age of onset is 53.9 years; women are more frequently affected (60%). No ethnic or geographical differences in incidence have been identified, although some diseases, such as multiple sclerosis (MS), do appear to increase the risk of TN. Familial cases are rare, accounting for 1%-2% of patients. Studies of familial cases report an autosomal dominant inheritance pattern with a genetic anticipation phenomenon. Due to the nature and the intensity of the pain, TN has a considerable impact on patients’ quality of life. These patients suffer as a result of diagnostic delay, fear of sudden onset of an attack, adverse reactions to treatment, and a lack of psychological support. The incidence of anxiety and depression among patients with TN is nearly 3 times higher than in the general population, as a result of the intensity of pain and long duration of the disease. The disease may also cause poor performance in activities of daily living, social isolation, sleep alterations, fatigue, and anorexia. In the light of all of the above, it is important for the management of these patients to take a multidisciplinary approach involving mental health professionals. TN can also have a considerable economic impact, as disease onset is usually during working age, and more than half of patients present difficulties performing work duties.

• #11 Microsurgical treatment of trigeminal neuralgia in patients older than 70 years: An efficacy and safety study | Neurología (English Edition)

  https://www.elsevier.es/en-revista-neurologia-english-edition–495-articulo-microsurgical-treatment-trigeminal-neuralgia-in-S2173580817301013

  Trigeminal neuralgia (TN) is a unilateral disorder characterised by paroxysmal, electric shock-like pain of abrupt termination limited to the territory of one or more branches of the trigeminal nerve. It is a rare condition, with an estimated annual incidence of 4.3-4.7 cases per 100000 population. It typically appears in adults older than 50. Its incidence has been found to increase with age up to rates of 17.5 and 25.6 cases per 100000 population in patients older than 60 and 70 years, respectively. […] Numerous studies have addressed immediate and long-term outcomes of MVD in series of patients followed up for a mean of over 5 years; these studies report initial success rates ranging between 76% and 99%, long-term success rates of 62% to 89%, and relapse rates of 4% to 38%. […] There is growing interest in MVD for elderly patients. This may be explained by population ageing and the increasing number of people who maintain a good health status until the last decades of life and wish to preserve their quality of life. Prevalence of TN starts to increase at the age of 60. If left untreated, this condition may significantly damage patients health. MVD has been shown to be superior to radiosurgery and percutaneous ablation techniques in terms of initial and long-term effectiveness; this superiority has been analysed in elderly patients setting the cut-off age at 65 or 70. […] As a general rule, success rates and pain-free survival times in elderly patients are similar to those seen in younger patients. In some series, elderly patients have achieved higher rates of complete pain resolution than younger patients.

• #12 Trigeminal neuralgia: MedlinePlus Medical EncyclopediaLock

  https://medlineplus.gov/ency/article/000742.htm

  Trigeminal neuralgia (TN) is a nerve disorder. It usually affects adults above age 50 years, but it can occur at any age. Women are affected more often than men. […] When TN affects people younger than 40, it is often due to MS or a tumor.

• #13 Epidemiology of trigeminal neuralgia: an electronic population health data study in Korea

  https://www.epain.org/journal/view.html?volume=34&number=3&spage=332

  Conclusions: The results in this study will not only help to study the characteristics of TN, but also serve as an important basis for the effective management of TN in Korea. […] In Korea, one study previously mentioned that the prevalence of TN was 81.8 per 100,000 person-years. However, there was no consideration of the various epidemiological characteristics of TN in that study. In the present study, we used the most up-to-date data available data between 2014 and 2018 in Korea, with other various parameters such as regional distribution, medical cost, healthcare resource utilization, and prescription patterns by medical specialty. In view of the regional distribution, TN was more prevalent in the metropolitan areas, such as Seoul and Gyeonggi. […] The medical cost for the treatment of TN in Korea has increased rapidly from 3,910,766 USD at the end of 2014 to 6,248,592 USD in 2018, with an increase of 159.77%.

• #14 Trigeminal neuralgia | Radiology Reference Article | Radiopaedia.org

  https://radiopaedia.org/articles/trigeminal-neuralgia?embed_domain=external.radpair.comradiopaedia-icon-144.pngfavicon.ico&lang=us

  The incidence of trigeminal neuralgia is approximately 4.3 per 100,000 per annum. The vast majority of cases are unilateral, with the right side of the face being affected more commonly (1.5:1); around 3% are bilateral. It peaks around age 60 to 70 years, and its prevalence increases with age 1,4. […] Multiple sclerosis may also cause trigeminal neuralgia and, indeed, its incidence is much higher in multiple sclerosis patients than in the general population. It is thought that both pontine plaques and neurovascular compression in combination produce a „double-crush” mechanism whereby intra-pontine inflammatory demyelination and cisternal mechanical demyelination affect the same first-order neurons 20. Of interest, high T2/FLAIR signal of the intrapontine segment of the trigeminal nerve is encountered in approximately 5% of cases, often symetrically 23. The etiology of this is unclear as is whether this finding increases the likelihood of trigeminal neuralgia 23.

• #15

  https://journals.lww.com/njms/fulltext/2019/10020/prevalence_of_trigeminal_neuralgia_in_indian.12.aspx

  The right side of the face is more involved than the left side, and it is more commonly found in rural population than urban population. […] TN is a rare nerve disorder having limited statistical data. […] Our study has been conducted on a large sample size and successful in establishing the prevalence and incidence of TN i.e it is more common in females than males, the right side of the face is more involved than the left side, and it is more commonly found in rural population than urban population.

• #16 Side of facial pain in trigeminal neuralgia in: Journal of Neurosurgery Volume 40 Issue 4 (1974) Journals

  https://thejns.org/view/journals/j-neurosurg/40/4/article-p514.xml

  The side of facial pain was studied in 508 patients with unilateral trigeminal neuralgia. The pain was left-sided in 38%. There was no association between the side of facial pain and handedness, or in a smaller group between the side of facial pain and an elevated ipsilateral petrous apex. The apparent right-sided predominance of trigeminal neuralgia remains unexplained.

• #17 Trigeminal neuralgia | MedLink Neurology

  https://www.medlink.com/articles/trigeminal-neuralgia

  In cases of trigeminal neuralgia caused by multiple sclerosis, the age of onset is younger than classical trigeminal neuralgia, and patients with multiple sclerosis have a 20-fold increased risk of developing trigeminal neuralgia than the general population. Whereas idiopathic or neurovascular trigeminal neuralgia is almost always (97%) unilateral, when trigeminal neuralgia occurs in multiple sclerosis, it may be bilateral in up to 30% of patients. The mechanism of injury in this population is a proposed double crush phenomenon, with the formation of a pontine plaque and neurovascular compression both playing a role. Trigeminal neuralgia secondary to multiple sclerosis is more prominent in females than males; one metaanalysis found a prevalence of 2.4% in males to 3.8% in females.

• #18 Trigeminal neuralgia | MS Trust

  https://mstrust.org.uk/a-z/trigeminal-neuralgia

  Recent research suggests that between four and six in every 100 people with MS experience trigeminal neuralgia which is about 400 times more often than the general population. […] Trigeminal neuralgia is sometimes an early symptom in MS, but it also becomes more likely the longer you have had MS. […] It is rare for people under 40 who do not have MS to experience trigeminal neuralgia so, for those in this age range, it is particularly important to consider if the symptom is part of their MS.

• #19 Trigeminal Neuralgia | PM&R KnowledgeNow

  https://now.aapmr.org/trigeminal-neuralgia/

  TN is a rare disease. Epidemiological studies showed that approximately 4 to 28.9/100,000 persons worldwide experience TN. In the United States, there are approximately 15,000 new cases each year. Classic TN accounts for about 80% of cases, secondary TN 15% and idiopathic TN 5%. Females are 1.5 times more likely to have trigeminal neuralgia. The disease can appear at any age however it is rare in children, and it occurs after age 40 in more than 90% of cases. Peak age of disease onset is between 52-58 years old for classical type TN and 30-35 years for the secondary form of TN. Familial cases, though rare, have also been reported. Hypertension and migraines may be risk factors for developing TN. No methods for primary prevention have been proposed.

• #20 Trigeminal neuralgia and its comorbidities: a nationwide disease trajectory study.

  https://vbn.aau.dk/en/publications/trigeminal-neuralgia-and-its-comorbidities-a-nationwide-disease-t

  There is a limited understanding of risk factors and comorbidities in trigeminal neuralgia, a disease characterized by paroxysms of severe unilateral facial pain and a higher incidence in women. […] We aim to identify temporally associated comorbidities involving trigeminal neuralgia by analyzing nationwide disease trajectories. […] Using data from 7.2 million unique individuals in the Danish National Patient Register between 1994 and 2018, each individual diagnosed with trigeminal neuralgia was compared with 10,000 matched controls to identify co-occurring diseases. […] In the Danish population, a trigeminal neuralgia diagnosis is temporally associated with 27 diseases revealed in systematic disease trajectories. […] Trigeminal neuralgia itself and its first-line treatment, but not a stroke polygenic risk score, was associated with an increased risk of ischemic stroke indicating that vascular risk factors should be routinely assessed in individuals with trigeminal neuralgia.

• #21 Trigeminal neuralgia: a practical guide | Practical Neurology

  https://pn.bmj.com/content/21/5/392

  Trigeminal neuralgia (TN) is characterised by recurrent, unilateral, brief (1s2min), very painful, electric shock-like pain episodes in the trigeminal distribution that are abrupt in onset and termination. […] Epidemiological studies show increased anxiety and depression, with increased risk of suicide. This highlights the importance of prompt diagnosis, investigations and treatment. […] The lifetime prevalence of TN is estimated to be 0.16%0.3%, while the annual incidence is 429 per 100000 person-years. It is more prevalent in women than in men (F:M ratio 3:2). The incidence increases with age, with a mean age of onset of 5357 years and range of 2493 years in adult series. Furthermore, a recent paediatric headache clinic of 1040 identified five children in the age range 9.516.5 years with TN.

• #22 Risk of psychiatric disorders following trigeminal neuralgia: a nationwide population-based retrospective cohort study | The Journal of Headache and Pain | Full Text

  https://thejournalofheadacheandpain.biomedcentral.com/articles/10.1186/s10194-015-0548-y

  Trigeminal neuralgia (TN) is a common cause of chronic orofacial pain. The annual incidence of TN is 4 to 13 per 100,000 people. Women are more often affected than men, with an approximate male to female ratio of 1:1.7. To date, national data and large-scale studies regarding the association between TN and risk of subsequent psychiatric disorders are lacking. Our nationwide population-based retrospective cohort study provides further evidence of an excessive risk of depressive, anxiety, and sleep disorders among patients with TN. Depressive, anxiety, and sleep disorders are treatable psychiatric illnesses and have great impact on the quality of life for patients with TN. Therefore, clinicians should be alerted to the possibility of patients with TN developing depressive, anxiety, or sleep disorders.

• #23 Risk of psychiatric disorders following trigeminal neuralgia: a nationwide population-based retrospective cohort study | The Journal of Headache and Pain | Full Text

  https://thejournalofheadacheandpain.biomedcentral.com/articles/10.1186/s10194-015-0548-y

  The adjusted hazard ratio (aHR) of depressive disorder, anxiety disorder and sleep disorder in subjects with TN was higher than that of the controls during the follow-up. […] A higher prevalence of psychiatric co-morbidities, especially depressive disorder, has been proven in patients with TN; however, a clear temporal-causal relationship between TN and specific psychiatric disorders has not been well established. […] Our study sample comprised 3273 patients with TN and 13,092 control patients without TN. During the follow-up period, 176 (5.4 %) patients with TN and 267 (2.0 %) comparison patients were diagnosed with psychiatric illnesses. Overall, significantly higher incidences of depressive disorder, anxiety disorder, and sleep disorder were observed in the patients with TN than in the comparison patients.

• #24

  https://journals.lww.com/ccmjournal/abstract/2013/12001/433__epidemiology_of_hospital_based_emergency.395.aspx

  Trigeminal neuralgia (TN) is a frequent cause of paroxysmal severe facial pain and headache in adults. The incidence of TN is thought to increase with age, with an annual incidence of 4 to 13 per 100,000 people in prior studies. […] During the study period, a total of 132,824 ED visits presented with trigeminal neuralgia. The mean age of these ED visits was 61.6 years. Females comprised 71.4% of all ED visits. Medicare was the major payer covering 52.4% of all ED visits. […] Trigeminal neuralgia is not an infrequent cause of emergency department visits in United States. Females and those in the 6th decade of life constitute the majority of visits. Hospital resource utilization is significant.

• #25 TNEPIX: Trigeminal Neuralgia epidemiology and informatics for characterising disease occurrence, patient journeys, healthcare impact and early diagnostic indications as an evidence package for establishment of UK specialist care centres | CPRD

  https://www.cprd.com/approved-studies/tnepix-trigeminal-neuralgia-epidemiology-and-informatics-characterising-disease

  Trigeminal Neuralgia (TN) is a rare facial pain condition. Prevalence estimates range from 0.1 to 0.2 per thousand patients. […] However, current average time to diagnosis is 7 years. […] Establishing more specialist care centres requires empirical evidence of distribution and patient diagnostic journey for TN in the UK. […] This study sets out to provide the required evidence in three areas: (a) epidemiological and geographical estimates, (b) patient journeys from symptoms through to diagnosis and to treatment outcomes, and (c) machine-learning derived early diagnostic and therapeutic options. […] We will obtain: prevalence, geographical distribution, time-to-diagnosis, number and type of referrals/visits (hospitals, AE, dentists, specialists, mental health support), diagnostic status after treatments, predictors in form of early symptoms or longitudinal patterns of misdiagnosis that can predict eventual TN diagnosis. […] The evidence obtained will support the Institute for Trigeminal Neuralgia in discussions with NHS England on establishing specialist TN care centres and pursuing early patient referral to those centres.

• #26 Trigeminal neuralgia epidemiology and demographics – wikidoc

  https://www.wikidoc.org/index.php/Trigeminal_neuralgia_epidemiology_and_demographics

  TN is a rare condition that affects women more than men. The annual incidence of TN is 4 to 13 per 100,000 people. […] Despite its low incidence, numbers may be significantly higher due to frequent misdiagnosis. TN is one of the more frequently seen neuralgias in the older adult population. The incidence increases gradually with age; most idiopathic cases begin after age 50, although onset may occur in the second and third decades or, rarely, in children. […] The male-to-female prevalence ratio of TN ranges from 1:1.5 to 1:1.7. This female predominance may be related to the increased longevity of women compared with men. Rare familial cases have been reported, but the vast majority of patients have sporadic disease.

• #27 Epidemiology: Trigeminal Neuralgia — The disease is not as rare as previously thought

  https://www.prnewswire.com/news-releases/epidemiology-trigeminal-neuralgia—-the-disease-is-not-as-rare-as-previously-thought-158892165.html

  Epidemiology: Trigeminal Neuralgia The disease is not as rare as previously thought […] This module provides an estimate of the number of diagnosed incident and total prevalent cases of trigeminal neuralgia in the seven major markets using historical trends for the disease and underlying risk factors. […] Datamonitor expects to see few diagnosed incident cases of trigeminal neuralgia in all of the seven major markets (the US, Japan, France, Germany, Italy, Spain, and the UK), with the majority of cases seen in the US and Germany. […] The forecast for total prevalent cases of the disease suggests the disease represents a bigger burden for the seven major markets than previously thought. […] Datamonitor epidemiologists forecast there were approximately 822,200 total prevalent cases of trigeminal neuralgia in the seven major markets in 2011.

• #28 The Molecular Basis and Pathophysiology of Trigeminal Neuralgia

  https://www.mdpi.com/1422-0067/23/7/3604

  Trigeminal neuralgia (TN) is a complex orofacial pain syndrome characterized by the paroxysmal onset of pain attacks in the trigeminal distribution. […] The estimated incidence of TN ranges from 4.3 to 26.8 per 100,000 person-years, with a lifetime prevalence of 0.03% to 0.3%. […] Although the causes are not fully elucidated, the incidence of TN in women is higher than men, and the average age of onset is 53, with the most affected ages between 37 and 67. […] Most cases of TN are sporadic without apparent risk factors. However, there have been a few reports of familial TN, which have led to investigations of the possible genetic and molecular basis to the pathophysiology of TN.

• #29 Interdisciplinary strategies for diagnosis and treatment of trigeminal neuralgia

  https://smw.ch/index.php/smw/article/download/3460/5981?inline=1

  Temporary, sudden, shooting and recurrent unilateral facial pain in the supply area of one or more trigeminal nerve branches characterises trigeminal neuralgia. […] The annual incidence of trigeminal neuralgia is about 4.327 per 100,000, with a lifetime prevalence of 160300 per 100,000. Women are twice as likely to be affected as men (F:M 2:1) and the average age of onset for classic trigeminal neuralgia is 53 years. […] Although some isolated cases within families imply a hereditary form of this condition, the genetic basis is still not well understood.

• #30 Trigeminal Neuralgia Market Size,Trends and Forecast 2024-2034

  https://www.imarcgroup.com/trigeminal-neuralgia-market

  The trigeminal neuralgia market has been comprehensively analyzed in IMARC’s new report titled „Trigeminal Neuralgia Market: Epidemiology, Industry Trends, Share, Size, Growth, Opportunity, and Forecast 2024-2034.” […] According to the report the United States has the largest patient pool for trigeminal neuralgia and also represents the largest market for its treatment. […] IMARC Group’s new report provides an exhaustive analysis of the trigeminal neuralgia market in the United States, EU5 (Germany, Spain, Italy, France, and United Kingdom) and Japan. This includes treatment practices, in-market, and pipeline drugs, share of individual therapies, market performance across the seven major markets, market performance of key companies and their drugs, etc. […] What is the number of prevalent cases (2018-2034) of trigeminal neuralgia across the seven major markets?

• #31 Trigeminal Neuralgia Market Size,Trends and Forecast 2024-2034

  https://www.imarcgroup.com/trigeminal-neuralgia-market

  What is the size of the trigeminal neuralgia patient pool (2018-2023) across the seven major markets? […] What would be the forecasted patient pool (2024-2034) across the seven major markets? […] What are the key factors driving the epidemiological trend of trigeminal neuralgia? […] What will be the growth rate of patients across the seven major markets?

• #32 Trigeminal neuralgia: therapeutic strategies to restore quality of life

  https://www.jofph.com/articles/10.22514/jofph.2024.024

  Trigeminal neuralgia (TN) usually affects the maxillary and mandibular branches of the fifth cranial nerve. […] TN is uncommon however, it significantly affects patients quality of life because the neuropathic pain worsens over time. […] Although several studies focused on TN have been reported, a treatment modality with 100% efficacy is lacking. […] The first-line treatment is pharmacological however, surgery may be required if symptoms persist.

• #33 Update on neuropathic pain treatment for trigeminal neuralgia | Neurosciences Journal

  https://nsj.org.sa/content/20/2/107

  Trigeminal neuralgia (TN) is one of the most common causes of facial pain seen in dental and neurologic practices. […] Epidemiological studies reveal a global incidence of approximately 4-28.9 per 100,000 individuals. […] Surgical interventions are reserved for patients who do not respond to adequate medical therapy. Microvascular decompression (MVD), percutaneous trigeminal rhizotomies, and gamma knife radiosurgery (GKRS) are possibly effective in the treatment of TN. […] It is estimated that up to 50% of patients with TN will require some form of surgery sooner or later.

• #34 Burden of illness of trigeminal neuralgia among patients managed in a specialist center in England | The Journal of Headache and Pain | Full Text

  https://thejournalofheadacheandpain.biomedcentral.com/articles/10.1186/s10194-020-01198-z

  Even though most patients reported improvement since beginning treatment, the majority were still on medications, with 42% of those individuals on polytherapy. […] It is crucial that patients are aware of all available options and can change their management plans quickly depending on the status of their TN. The high numbers of current or prior medications, residual pain or complications despite surgical and/or medical interventions, and reduced QoL in those with current pain interference highlights the BOI of TN and the remaining unmet medical need.

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