Brodawki podeszwowe
Etiologia i przyczyny
Brodawki podeszwowe (verruca plantaris) są zmianami skórnymi wywołanymi przez infekcję wirusem brodawczaka ludzkiego (HPV), głównie typami HPV-1, HPV-2, HPV-4 oraz innymi rzadziej spotykanymi. Wirus wnika przez mikrourazy naskórka stóp, szczególnie w miejscach zwiększonego nacisku, takich jak pięty i główki kości śródstopia. Okres inkubacji może trwać od kilku tygodni do 20 miesięcy. HPV namnaża się w warstwie podstawnej naskórka, stymulując proliferację keratynocytów i prowadząc do powstania hiperkeratotycznych brodawek, które mogą występować pojedynczo (typ myrmecia, bolesne, głębokie, związane z HPV-1) lub w formie mozaikowej (skupiska, powierzchowne, mniej bolesne, związane z HPV-2). Zakażenie szerzy się drogą kontaktu bezpośredniego, pośredniego (fomity) oraz autoinokulacji, a sprzyjają mu ciepłe i wilgotne środowiska, takie jak baseny, szatnie czy wnętrza butów.
- Etiologia brodawek podeszwowych
- Typy wirusa HPV odpowiedzialne za brodawki podeszwowe
- Mechanizm infekcji i rozwoju brodawek podeszwowych
- Drogi szerzenia się infekcji
- Czynniki ryzyka rozwoju brodawek podeszwowych
- Lokalizacja i rodzaje brodawek podeszwowych
- Zjawisko eliminacji wirusa i nawroty
- Powikłania i przypadki szczególne
- Podsumowanie etiologii brodawek podeszwowych
Etiologia brodawek podeszwowych
Brodawki podeszwowe (verruca plantaris) to zmiany skórne zlokalizowane na podeszwowej części stopy, spowodowane infekcją wirusem brodawczaka ludzkiego (HPV – Human Papillomavirus). HPV jest powszechnie występującym wirusem, który infekuje komórki naskórka, powodując nadmierny wzrost i rogowacenie tkanki, co prowadzi do powstania charakterystycznych zmian na skórze.12
Typy wirusa HPV odpowiedzialne za brodawki podeszwowe
Istnieje ponad 150 typów wirusa HPV, jednak tylko niektóre z nich są odpowiedzialne za powstawanie brodawek podeszwowych. Najczęściej izolowanymi typami HPV z brodawek podeszwowych są:34
- HPV-1 (najczęściej odpowiedzialny za brodawki podeszwowe typu myrmecia)
- HPV-2, HPV-4 (częste w przypadku brodawek mozaikowych)
- HPV-3, HPV-27, HPV-29, HPV-57
- HPV-60 (związany z podeszwowymi torbielami naskórkowymi)
- HPV-63, HPV-65, HPV-66, HPV-69
Podczas gdy wirus HPV jest związany również z innymi rodzajami brodawek i zmian skórnych, należy podkreślić, że typy HPV powodujące brodawki podeszwowe różnią się od typów odpowiedzialnych za brodawki narządów płciowych.89
Mechanizm infekcji i rozwoju brodawek podeszwowych
Infekcja wirusem HPV i rozwój brodawek podeszwowych przebiega według następującego schematu:1011
- Wniknięcie wirusa do organizmu – wirus HPV wnika do organizmu przez drobne uszkodzenia naskórka, takie jak mikrourazy, pęknięcia, otarcia czy rany na podeszwach stóp.12
- Zakażenie komórek warstwy podstawnej naskórka – wirus dostaje się do warstwy bazalnej naskórka, gdzie znajdują się aktywnie dzielące się komórki macierzyste.13
- Okres inkubacji – po zakażeniu występuje okres inkubacji trwający od kilku tygodni do nawet 20 miesięcy, zanim pojawią się widoczne objawy.14
- Namnażanie wirusa – DNA wirusa ustala się w komórce gospodarza, zazwyczaj bez integracji z genomem komórki gospodarza. Białka wirusowe E1 i E2 stymulują namnażanie materiału genetycznego wirusa.15
- Stymulacja podziałów komórkowych – zakażone komórki skóry zaczynają szybciej się dzielić, co prowadzi do nadmiernego rogowacenia naskórka i powstania hyperkeratotycznej brodawki.16
Po zakażeniu wirusem HPV możliwe są trzy różne wyniki:17
- Eliminacja infekcji z wytworzeniem odporności na dany typ HPV
- Zakażenie latentne (bezobjawowe)
- Klinicznie jawna infekcja w postaci brodawki podeszwowej
Drogi szerzenia się infekcji
Wirus HPV odpowiedzialny za brodawki podeszwowe może szerzyć się następującymi drogami:1819
- Kontakt bezpośredni – poprzez bezpośredni kontakt ze skórą osoby zakażonej, chociaż szczepy HPV wywołujące brodawki podeszwowe nie są wysoce zakaźne w przypadku kontaktu bezpośredniego.2021
- Kontakt pośredni – poprzez kontakt z zanieczyszczonymi powierzchniami lub przedmiotami (tzw. fomity), takimi jak podłogi, skarpetki, buty, ręczniki i sprzęt sportowy.2223
- Autoinokulacja – poprzez samoprzeniesienie wirusa na inne części ciała lub inne obszary skóry tej samej osoby.2425
Wirus HPV odpowiedzialny za brodawki podeszwowe rozwija się najlepiej w ciepłych i wilgotnych środowiskach, takich jak:2627
- Baseny i ich otoczenie
- Szatnie i prysznice publiczne
- Siłownie i kluby fitness
- Sauny i łaźnie parowe
- Wilgotne i ciepłe wnętrza butów
Czynniki ryzyka rozwoju brodawek podeszwowych
Chociaż każdy może zostać zakażony wirusem HPV, niektóre grupy osób są bardziej narażone na rozwój brodawek podeszwowych:2829
- Wiek – dzieci i młodzież są bardziej podatne na infekcję ze względu na niedojrzały układ odpornościowy i częstsze chodzenie boso.3031
- Osłabiony układ odpornościowy – osoby z obniżoną odpornością, np. pacjenci po przeszczepach narządów, osoby z chorobami autoimmunologicznymi, pacjenci w trakcie chemioterapii, osoby z cukrzycą.3233
- Wcześniejsze zakażenie brodawkami – posiadanie brodawki zwiększa ryzyko rozwoju kolejnych, ze względu na wysokie miano wirusa i zwiększone shedding (wydalanie) cząstek wirusowych.34
- Bliski kontakt z osobą zakażoną – szczególnie w przypadku współmieszkańców i członków rodziny.35
- Chodzenie boso w miejscach publicznych, takich jak baseny, szatnie i prysznice.3637
- Uszkodzenia skóry stóp – drobne urazy, pęknięcia, otarcia, które stanowią wrota zakażenia.38
- Nadmierna potliwość stóp – zwiększa podatność skóry na infekcję.39
Lokalizacja i rodzaje brodawek podeszwowych
Brodawki podeszwowe mają tendencję do rozwijania się w miejscach zwiększonego nacisku na podeszwę stopy, gdzie występuje większe mikrouszkodzenie bariery naskórkowej, co zwiększa prawdopodobieństwo inwazji HPV:40
- Pięty
- Główki kości śródstopia (przodostopie)
- Miejsca obciążenia podczas chodzenia i stania
Wyróżnia się dwa główne rodzaje brodawek podeszwowych:4142
- Brodawki pojedyncze (myrmecia) – typowo bolesne, głębiej wrastające, powodowane głównie przez HPV-1. Charakteryzują się żółtym hiperkeratotycznym naskórkiem przypominającym odcisk, z przerwaniem linii skórnych w obrębie brodawki.
- Brodawki mozaikowe – występujące w skupiskach, bardziej powierzchowne, mniej bolesne, zazwyczaj powodowane przez HPV-2.
Zjawisko eliminacji wirusa i nawroty
Po zakażeniu HPV, spontaniczna eliminacja wirusa zależy od rozwoju odpowiedzi immunologicznej, w szczególności limfocytów, które niszczą komórki zakażone wirusem.43 Warto jednak zauważyć, że wirus HPV może pozostawać w organizmie w formie latentnej nawet po ustąpieniu klinicznych objawów infekcji.44
Cechy charakterystyczne zakażenia wirusem HPV w kontekście brodawek podeszwowych to:45
- Wirus może być obecny w organizmie przez tygodnie lub lata przed pojawieniem się brodawki
- Utrzymuje się w organizmie przez całe życie, nawet po ustąpieniu brodawki
- Może prowadzić do nawrotów w tym samym miejscu, np. gdy osoba nosząca wirusa staje się immunosupresyjna
Powikłania i przypadki szczególne
W większości przypadków brodawki podeszwowe są łagodnymi zmianami, które nie stanowią poważnego zagrożenia dla zdrowia.46 Jednakże, w rzadkich przypadkach, szczególnie u osób z obniżoną odpornością, brodawki utrzymujące się przez dłuższy czas mogą ulegać złośliwej transformacji w raka kolczystokomórkowego lub brodawkowatego raka podeszwowego.47
U pacjentów z obniżoną odpornością obserwuje się wyższy wskaźnik występowania brodawek podeszwowych, a także zwiększoną ciężkość i czas trwania zmian.48 Należy również zwrócić uwagę, że u pacjentów po przeszczepach narządów brodawki podeszwowe występują bardzo często.49
Podsumowanie etiologii brodawek podeszwowych
Brodawki podeszwowe są spowodowane infekcją specyficznymi typami wirusa brodawczaka ludzkiego (HPV), który wnika do organizmu przez mikrouszkodzenia skóry stóp. Wirus ten rozwija się najlepiej w ciepłych i wilgotnych środowiskach, a do zakażenia dochodzi najczęściej w miejscach publicznych, takich jak baseny czy szatnie. Na rozwój brodawek podeszwowych szczególnie narażone są dzieci, młodzież oraz osoby z obniżoną odpornością. Zakażenie może prowadzić do rozwoju pojedynczych brodawek typu myrmecia lub brodawek mozaikowych występujących w skupiskach. Chociaż w większości przypadków brodawki podeszwowe są zmianami łagodnymi, mogą powodować znaczny dyskomfort i ból, a w rzadkich przypadkach prowadzić do poważniejszych powikłań.5051
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Materiały źródłowe
- #1 Plantar warts – Symptoms and causes – Mayo Clinichttps://www.mayoclinic.org/diseases-conditions/plantar-warts/symptoms-causes/syc-20352691
Plantar warts are caused by the same type of virus that causes warts on your hands and fingers. But, because of their location, they can be painful. […] Plantar warts are caused by HPV. This virus enters through tiny cuts or breaks on the bottom of the feet. […] Plantar warts are caused by an infection with HPV in the outer layer of skin on the soles of the feet. The warts develop when the virus enters through tiny cuts, breaks or weak spots on the bottom of the foot. […] HPV is very common, and more than 100 kinds of the virus exist. But only a few of them cause warts on the feet. Other types of HPV are more likely to cause warts on other areas of your skin or on mucous membranes. […] The HPV strains that cause plantar warts aren’t highly contagious. So the virus isn’t easily spread by direct contact from one person to another. But it thrives in warm, moist places, so you might get the virus by walking barefoot around swimming pools or locker rooms. If the virus spreads from the first site of infection, more warts may grow.
- #2 Plantar Warts: Symptoms, Causes, Treatment & Removalhttps://my.clevelandclinic.org/health/diseases/24899-plantar-warts
Plantar warts are a type of skin infection on your feet caused by the human papillomavirus (HPV). […] They develop when the human papillomavirus (HPV) enters a cut or break in your skin and causes an infection. […] HPV causes plantar warts. When HPV enters a cut or break in your skin, it causes a skin infection that forms a plantar wart. It may take two to six months after HPV exposure for plantar warts to appear. […] Plantar warts are contagious. They spread from direct contact with HPV, through either skin-to-skin contact or sharing items such as shoes, socks and towels. […] HPV types 1, 2, 3, 4, 27 and 57 cause plantar warts. Skin-to-skin sexual contact doesnt spread these types of HPV, so they arent STDs.
- #3 Plantar Warts: Epidemiology, Pathophysiology, and Clinical Managementhttps://www.degruyter.com/document/doi/10.7556/jaoa.2018.024/html?lang=en
Verrucae plantaris (plantar warts) are common cutaneous lesions of the plantar aspect of the foot that are caused by the human papillomavirus (HPV). […] The cause of plantar warts, HPV, is not a single virus but rather a group of nonenveloped DNA viruses that are categorized into more than 150 types according to similarities within their DNA sequences. […] The types of HPV that have been isolated from plantar warts include HPV-1, -2, -3, -4, -27, -29, -57, -60, -63, -65, -66, and -69. […] Human papillomavirus is species specific to human hosts, and humans are the primary reservoir of the virus. […] The virus is transmitted via contact with HPV particles. […] Infection of a host requires direct contact with viral particles, which can occur through either direct contact via a plantar wart or indirect contact via fomites, such as flooring, socks, shoes, towels, and sports equipment.
- #4 Plantar wart – Wikipediahttps://en.wikipedia.org/wiki/Plantar_wart
Plantar warts are benign epithelial tumors generally caused by infection by human papillomavirus types 1, 2, 4, 60, or 63, but also by types 57, 65, 66, and 156. […] The virus attacks compromised skin through direct contact, possibly entering through tiny cuts and abrasions in the stratum corneum (outermost layer of skin). […] A break in the skin is required for infection to occur. […] Risk factors include use of communal showers, having had prior warts, and poor immune function. […] Warts may spread through autoinoculation, by infecting nearby skin, or by contaminated walking surfaces.
- #5 Plantar Warts: Epidemiology, Pathophysiology, and Clinical Managementhttps://www.degruyterbrill.com/document/doi/10.7556/jaoa.2018.024/html?lang=en&srsltid=AfmBOorKydgR6MZAMtohtVamHILQMycBeOTGNEOk-IH0BbfEYUsx6zUp
Verrucae plantaris (plantar warts) are common cutaneous lesions of the plantar aspect of the foot that are caused by the human papillomavirus (HPV). […] The cause of plantar warts, HPV, is not a single virus but rather a group of nonenveloped DNA viruses that are categorized into more than 150 types according to similarities within their DNA sequences. […] The types of HPV that have been isolated from plantar warts include HPV-1, -2, -3, -4, -27, -29, -57, -60, -63, -65, -66, and -69. […] Human papillomavirus is species specific to human hosts, and humans are the primary reservoir of the virus. […] The virus is transmitted via contact with HPV particles. […] Infection of a host requires direct contact with viral particles, which can occur through either direct contact via a plantar wart or indirect contact via fomites, such as flooring, socks, shoes, towels, and sports equipment.
- #6 Wart – StatPearls – NCBI Bookshelfhttps://www.ncbi.nlm.nih.gov/books/NBK431047/
Warts are prevalent benign lesions caused by the human papillomavirus (HPV) that occur in the mucosa and skin. […] Warts are caused by the human papillomavirus (HPV), with over 100 types of HPV identified. […] There are over 100 subtypes of the HPV virus, but only a few types can cause skin warts at selective anatomical sites. […] HPV tends to cause genital warts, flat warts, and palmoplantar warts. […] Warts are easily transmitted by direct or indirect contact, especially if there is the disruption of the normal epithelial barrier. […] HPV usually only infects the epithelial layers of skin, and systemic dissemination is very rare. […] Common warts are associated with HPV types 2, 4 (most common), followed by types 1, 3, 27, 29, and 57 […] Deep palmoplantar warts are caused by types 1 (most common) followed by types 2, 3, 4, 27, and 57. […] Malignant transformation tends to occur in individuals with genital warts and those who are immunocompromised. […] HPV strains 5, 8, 20, and 47 also have malignant potential in individuals with epidermodysplasia verruciformis.
- #7 Warts, verrucas, human papillomavirus infectionhttps://dermnetnz.org/topics/viral-wart
Warts are due to infection by the human papillomavirus (HPV), a double-stranded DNA virus. There are more than 150 known HPV types, only some of which infect the skin, giving rise to a variety of clinical presentations. […] The most common HPV types infecting the skin are types 1, 2, 3, 4, 10, 27, 29, and 57. […] HPV is spread by direct skin-to-skin contact or autoinoculation; if a wart is scratched or picked, a wart may develop under the fingernail (subungual wart) or virus may be spread to another area of skin. […] Plantar warts (verruca plantaris) include tender inwardly growing myrmecia on the sole caused by HPV 1, and clusters of superficial less painful mosaic warts due to HPV 2. […] Myrmecial warts are typically tender with lateral and direct pressure, are surrounded by yellow hyperkeratotic callus-like skin showing accentuated skin markings, but with discontinuation of the skin lines through the actual wart. […] Plantar epidermoid cysts are associated with HPV 60 infection of the eccrine ducts.
- #8 Patient education: Common warts, plantar warts, and flat warts (Beyond the Basics) – UpToDatehttps://www.uptodate.com/contents/common-warts-plantar-warts-and-flat-warts-beyond-the-basics/print
Skin warts are growths on the skin that are caused by a virus called human papillomavirus (HPV). HPV infection is common; there are different types, some of which can cause warts. […] The types of HPV that cause common warts, plantar warts, or flat warts are usually different from the types of HPV that cause genital warts. […] People can become infected with the virus that causes warts (HPV) by touching another person’s wart. HPV is more likely to infect skin that is injured or softened by water, but they can infect healthy skin as well. It can take up to six months or longer after exposure to the virus for a wart to appear. […] Plantar warts are found on the soles of the feet. Plantar warts often begin as a small, round area of rough or thickened skin but may grow to involve larger areas. Close examination of a plantar wart will show that it interrupts the normal skin lines that are found on the soles of the feet. Small, clogged blood vessels, which look like black dots or tiny seeds, are also commonly seen in plantar warts.
- #9 Plantar Warts and Palmar Warts: Treatments and Causeshttps://www.webmd.com/skin-problems-and-treatments/plantar-warts-palmar-warts
Plantar warts and palmar warts are noncancerous skin growths caused by a viral infection in the top layer of the skin. The culprit is a strain of virus called human papillomavirus (HPV). […] A person’s risk of getting a wart varies. Those with a weakened immune system are more likely to get it. But those with healthy immune systems can also develop warts. […] Some people mistakenly think plantar warts or palmar warts are malignant. But they aren’t harmful.
- #10 Plantar Warts: Epidemiology, Pathophysiology, and Clinical Managementhttps://www.degruyter.com/document/doi/10.7556/jaoa.2018.024/html?lang=en
Verrucae plantaris (plantar warts) are common cutaneous lesions of the plantar aspect of the foot that are caused by the human papillomavirus (HPV). […] The cause of plantar warts, HPV, is not a single virus but rather a group of nonenveloped DNA viruses that are categorized into more than 150 types according to similarities within their DNA sequences. […] The types of HPV that have been isolated from plantar warts include HPV-1, -2, -3, -4, -27, -29, -57, -60, -63, -65, -66, and -69. […] Human papillomavirus is species specific to human hosts, and humans are the primary reservoir of the virus. […] The virus is transmitted via contact with HPV particles. […] Infection of a host requires direct contact with viral particles, which can occur through either direct contact via a plantar wart or indirect contact via fomites, such as flooring, socks, shoes, towels, and sports equipment.
- #11 Plantar Warts: Epidemiology, Pathophysiology, and Clinical Managementhttps://www.degruyter.com/document/doi/10.7556/jaoa.2018.024/html?lang=en
Once in contact with a host, HPV gains entry to the basal epithelial layer, where actively dividing stem cells are located. […] After infection, if the virus is not cleared, the host basal keratinocyte is stimulated to divide and replicate viral DNA via HPV E1 and E2 proteins. […] Once infection occurs, 3 outcomes are possible: clearance of the infection with resultant immunity to that particular HPV type, latent infection, or clinically manifested infection as a plantar wart. […] The induction of cellular replication throughout the process of viral genome amplification leads to the hyperkeratinized papule that constitutes a plantar wart. […] Plantar warts tend to develop at areas of increased pressure on the sole of the foot, including the heel and metatarsal heads. […] Such pressure points are regions of increased microtrauma to the epidermal barrier, which increases the likelihood of HPV invasion.
- #12 Warts on the feet (plantar warts): Causes, prevention, and treatmenthttps://www.medicalnewstoday.com/articles/warts-on-feet
Plantar warts are warts that grow on the feet. They are noncancerous skin growths that result from infection with the human papillomavirus (HPV). […] Plantar warts result from HPV infections. Warts occur when the virus enters skin cells through cuts or injuries on the bottom of the foot. The virus makes the skin cells grow more quickly, which causes a thickened bump, or wart, to form. […] HPV is very common and contagious, with hundreds of variations. However, only a few types of HPV cause plantar warts. The viruses perform best in warm, moist places such as communal areas near swimming pools, and they are most likely to infect moist or injured skin.
- #13 Plantar Warts: Epidemiology, Pathophysiology, and Clinical Managementhttps://www.degruyterbrill.com/document/doi/10.7556/jaoa.2018.024/html?lang=en&srsltid=AfmBOorKydgR6MZAMtohtVamHILQMycBeOTGNEOk-IH0BbfEYUsx6zUp
Once in contact with a host, HPV gains entry to the basal epithelial layer, where actively dividing stem cells are located. […] After an incubation period of 1 to 20 months, viral DNA is then established within the host cell, usually without integration into the host cell genome. […] Once infection occurs, 3 outcomes are possible: clearance of the infection with resultant immunity to that particular HPV type, latent infection, or clinically manifested infection as a plantar wart. […] The induction of cellular replication throughout the process of viral genome amplification leads to the hyperkeratinized papule that constitutes a plantar wart. […] Plantar warts tend to develop at areas of increased pressure on the sole of the foot, including the heel and metatarsal heads. […] Two of the most significant risk factors for developing plantar warts are (1) having a preexistent wart and (2) having close contact with someone who has a preexistent wart.
- #14 Plantar Wart: Causes, Symptoms, Treatment and Costhttps://www.lybrate.com/topic/plantar-wart
Plantar warts are caused by a virus called the Human Papillomavirus (HPV), which is present in the environment and can be contracted through direct contact with an infected person or object. […] The virus enters through tiny cuts or broken areas on the soles of your feet, which can occur from walking barefoot in public areas. […] It may take weeks or months for a plantar wart to develop after exposure to the virus.
- #15 Plantar Warts: Epidemiology, Pathophysiology, and Clinical Managementhttps://www.degruyter.com/document/doi/10.7556/jaoa.2018.024/html?lang=en
Once in contact with a host, HPV gains entry to the basal epithelial layer, where actively dividing stem cells are located. […] After infection, if the virus is not cleared, the host basal keratinocyte is stimulated to divide and replicate viral DNA via HPV E1 and E2 proteins. […] Once infection occurs, 3 outcomes are possible: clearance of the infection with resultant immunity to that particular HPV type, latent infection, or clinically manifested infection as a plantar wart. […] The induction of cellular replication throughout the process of viral genome amplification leads to the hyperkeratinized papule that constitutes a plantar wart. […] Plantar warts tend to develop at areas of increased pressure on the sole of the foot, including the heel and metatarsal heads. […] Such pressure points are regions of increased microtrauma to the epidermal barrier, which increases the likelihood of HPV invasion.
- #16 What Triggers Plantar Warts and How Do You Treat Them?https://www.verywellhealth.com/what-are-plantar-warts-1337762
Plantar warts form on the bottom of the foot. This part of your foot is called the plantar surface. The growths appear on the top layer of skin called the epidermis. They are caused by the human papillomavirus (HPV). […] All warts are caused by HPV. It’s the same virus that causes genital warts. There are more than 100 strains of HPV, but the HPV-1 strain is the most common cause of plantar warts. However, HPV types 2, 4, 60, and 63 also cause plantar warts. […] Once they’ve been infected with HPV, the skin cells begin to multiply rapidly. As they build up, the cells form a wart. […] However, a wart may not develop for several weeks or months after an infection occurs. Once the wart has appeared, the virus can move from the first overgrowth to nearby breaks in the skin. […] Not everyone exposed to HPV will get a wart. It’s more likely to happen to: People with weak immune systems, Those who frequently walk barefoot on moist surfaces (like locker room floors), People who have sweaty feet. […] Plantar warts are caused by HPV. They usually appear on the bottom of the feet and are easily spread. You may have a single wart of a group of them.
- #17 Plantar Warts: Epidemiology, Pathophysiology, and Clinical Managementhttps://www.degruyterbrill.com/document/doi/10.7556/jaoa.2018.024/html?lang=en&srsltid=AfmBOorKydgR6MZAMtohtVamHILQMycBeOTGNEOk-IH0BbfEYUsx6zUp
Once in contact with a host, HPV gains entry to the basal epithelial layer, where actively dividing stem cells are located. […] After an incubation period of 1 to 20 months, viral DNA is then established within the host cell, usually without integration into the host cell genome. […] Once infection occurs, 3 outcomes are possible: clearance of the infection with resultant immunity to that particular HPV type, latent infection, or clinically manifested infection as a plantar wart. […] The induction of cellular replication throughout the process of viral genome amplification leads to the hyperkeratinized papule that constitutes a plantar wart. […] Plantar warts tend to develop at areas of increased pressure on the sole of the foot, including the heel and metatarsal heads. […] Two of the most significant risk factors for developing plantar warts are (1) having a preexistent wart and (2) having close contact with someone who has a preexistent wart.
- #18 Plantar Warts: Epidemiology, Pathophysiology, and Clinical Managementhttps://www.degruyter.com/document/doi/10.7556/jaoa.2018.024/html?lang=en
Verrucae plantaris (plantar warts) are common cutaneous lesions of the plantar aspect of the foot that are caused by the human papillomavirus (HPV). […] The cause of plantar warts, HPV, is not a single virus but rather a group of nonenveloped DNA viruses that are categorized into more than 150 types according to similarities within their DNA sequences. […] The types of HPV that have been isolated from plantar warts include HPV-1, -2, -3, -4, -27, -29, -57, -60, -63, -65, -66, and -69. […] Human papillomavirus is species specific to human hosts, and humans are the primary reservoir of the virus. […] The virus is transmitted via contact with HPV particles. […] Infection of a host requires direct contact with viral particles, which can occur through either direct contact via a plantar wart or indirect contact via fomites, such as flooring, socks, shoes, towels, and sports equipment.
- #19 Plantar Warts: Epidemiology, Pathophysiology, and Clinical Managementhttps://www.degruyter.com/document/doi/10.7556/jaoa.2018.024/html?lang=en
Two of the most significant risk factors for developing plantar warts are (1) having a preexistent wart and (2) having close contact with someone who has a preexistent wart. […] Plantar warts have a very high viral load, which increases the rate of viral shedding and the likelihood of contaminating adjacent body surfaces, inanimate communal surfaces, or close contacts. […] Walking barefoot also increases the likelihood of contacting HPV, especially if one walks barefoot in an area where others have walked barefoot, such as pool decks or communal showers. […] Immunocompromised patients have higher rates of plantar warts, along with increased severity and duration of the lesions.
- #20 Plantar warts – Symptoms and causes – Mayo Clinichttps://www.mayoclinic.org/diseases-conditions/plantar-warts/symptoms-causes/syc-20352691
Plantar warts are caused by the same type of virus that causes warts on your hands and fingers. But, because of their location, they can be painful. […] Plantar warts are caused by HPV. This virus enters through tiny cuts or breaks on the bottom of the feet. […] Plantar warts are caused by an infection with HPV in the outer layer of skin on the soles of the feet. The warts develop when the virus enters through tiny cuts, breaks or weak spots on the bottom of the foot. […] HPV is very common, and more than 100 kinds of the virus exist. But only a few of them cause warts on the feet. Other types of HPV are more likely to cause warts on other areas of your skin or on mucous membranes. […] The HPV strains that cause plantar warts aren’t highly contagious. So the virus isn’t easily spread by direct contact from one person to another. But it thrives in warm, moist places, so you might get the virus by walking barefoot around swimming pools or locker rooms. If the virus spreads from the first site of infection, more warts may grow.
- #21 Plantar wartshttps://johnsonmemorial.org/jmh-health/disease-conditions/con-20305521
Plantar warts are caused by HPV. This virus enters through tiny cuts or breaks on the bottom of the feet. […] Plantar warts are caused by an infection with HPV in the outer layer of skin on the soles of the feet. The warts develop when the virus enters through tiny cuts, breaks or weak spots on the bottom of the foot. […] HPV is very common, and more than 100 kinds of the virus exist. But only a few of them cause warts on the feet. Other types of HPV are more likely to cause warts on other areas of your skin or on mucous membranes. […] The HPV strains that cause plantar warts aren’t highly contagious. So the virus isn’t easily spread by direct contact from one person to another. But it thrives in warm, moist places, so you might get the virus by walking barefoot around swimming pools or locker rooms. If the virus spreads from the first site of infection, more warts may grow.
- #22 Plantar Warts: Epidemiology, Pathophysiology, and Clinical Managementhttps://www.degruyter.com/document/doi/10.7556/jaoa.2018.024/html?lang=en
Verrucae plantaris (plantar warts) are common cutaneous lesions of the plantar aspect of the foot that are caused by the human papillomavirus (HPV). […] The cause of plantar warts, HPV, is not a single virus but rather a group of nonenveloped DNA viruses that are categorized into more than 150 types according to similarities within their DNA sequences. […] The types of HPV that have been isolated from plantar warts include HPV-1, -2, -3, -4, -27, -29, -57, -60, -63, -65, -66, and -69. […] Human papillomavirus is species specific to human hosts, and humans are the primary reservoir of the virus. […] The virus is transmitted via contact with HPV particles. […] Infection of a host requires direct contact with viral particles, which can occur through either direct contact via a plantar wart or indirect contact via fomites, such as flooring, socks, shoes, towels, and sports equipment.
- #23 What Causes Plantar Warts? | Foot and Ankle Specialty Centershttps://www.footankleaz.com/blog/foot-health/plantar-wart-causes/
Shoes and socks are among the plantar wart causes. The virus can live in shoes and socks. […] High in the list of plantar wart causes, we have a virus called HPV, which stands for Human Papillomavirus. […] Immune system weakness can make it harder for your body to fight off plantar wart causes. […] The real cause is still the HPV virus. Deficiencies just make it easier for the virus to take hold. […] People at risk of plantar warts causes include: Kids, Teens, Athletes, Weakened Immunity, Pool/Gym Users. […] Touching the HPV virus, especially in public places like showers and pools. […] Yes. They are always caused by certain types of HPV. […] Yes, they always come from HPV.
- #24 Plantar wart – Wikipediahttps://en.wikipedia.org/wiki/Plantar_wart
Plantar warts are benign epithelial tumors generally caused by infection by human papillomavirus types 1, 2, 4, 60, or 63, but also by types 57, 65, 66, and 156. […] The virus attacks compromised skin through direct contact, possibly entering through tiny cuts and abrasions in the stratum corneum (outermost layer of skin). […] A break in the skin is required for infection to occur. […] Risk factors include use of communal showers, having had prior warts, and poor immune function. […] Warts may spread through autoinoculation, by infecting nearby skin, or by contaminated walking surfaces.
- #25 Warts, verrucas, human papillomavirus infectionhttps://dermnetnz.org/topics/viral-wart
Warts are due to infection by the human papillomavirus (HPV), a double-stranded DNA virus. There are more than 150 known HPV types, only some of which infect the skin, giving rise to a variety of clinical presentations. […] The most common HPV types infecting the skin are types 1, 2, 3, 4, 10, 27, 29, and 57. […] HPV is spread by direct skin-to-skin contact or autoinoculation; if a wart is scratched or picked, a wart may develop under the fingernail (subungual wart) or virus may be spread to another area of skin. […] Plantar warts (verruca plantaris) include tender inwardly growing myrmecia on the sole caused by HPV 1, and clusters of superficial less painful mosaic warts due to HPV 2. […] Myrmecial warts are typically tender with lateral and direct pressure, are surrounded by yellow hyperkeratotic callus-like skin showing accentuated skin markings, but with discontinuation of the skin lines through the actual wart. […] Plantar epidermoid cysts are associated with HPV 60 infection of the eccrine ducts.
- #26 Plantar Warts: Symptoms, Causes, Remuval & Treatment | Adahttps://ada.com/conditions/plantar-warts/
Plantar warts are caused by the human papillomavirus (HPV) an umbrella term for a group of viruses that affect the skin. The virus causes an excess of the protein keratin to develop on the surface of the skin, resulting in warts. […] HPV can cause warts anywhere on the body, however, only warts on the foot are classed as plantar warts. The virus typically enters the skin through small cuts or weak spots in the outermost layer of the skin and can take a number of weeks or months to produce visible warts. […] The HPV that causes plantar warts is contagious. It can be passed from person to person, as well as indirectly through surfaces or objects. The virus particularly thrives in warm, moist environments, meaning it is commonly contracted in swimming pools or locker rooms.
- #27 Understanding Plantar Warts: Causes and Treatment | Shady Grove Podiatryhttps://www.shadygrovepodiatry.com/understanding-plantar-warts-causes-and-treatment/
Plantar warts are a common skin condition caused by the human papillomavirus (HPV). […] Plantar warts are caused by specific strains of HPV that enter the body through small cuts or cracks in the skin on the feet. […] These viruses thrive in warm, moist environments such as swimming pools and locker rooms, so walking barefoot in these areas can increase the risk of developing plantar warts.
- #28 Plantar Warts: Epidemiology, Pathophysiology, and Clinical Managementhttps://www.degruyter.com/document/doi/10.7556/jaoa.2018.024/html?lang=en
Two of the most significant risk factors for developing plantar warts are (1) having a preexistent wart and (2) having close contact with someone who has a preexistent wart. […] Plantar warts have a very high viral load, which increases the rate of viral shedding and the likelihood of contaminating adjacent body surfaces, inanimate communal surfaces, or close contacts. […] Walking barefoot also increases the likelihood of contacting HPV, especially if one walks barefoot in an area where others have walked barefoot, such as pool decks or communal showers. […] Immunocompromised patients have higher rates of plantar warts, along with increased severity and duration of the lesions.
- #29 Top Risk Factors for Plantar Warts – footsurgeonhttps://www.footsurgeon.com/top-risk-factors-for-plantar-warts/
Plantar warts are a type of wart that arises from a viral infection thats caused by Human Papilloma Virus, or HPV. […] HPV is a virus that is transmitted through either direct or indirect contact. This means that it is possible to get it directly from someone who has the virus. In addition, it is also possible to get the virus by touching surfaces or clothing that have also touched the warts of someone who is infected. […] HPV virus thrives in warm and most environments, which makes it common to be picked up from communal areas that experience high levels of skin contact. There are certain risk factors that can make one more predisposed to becoming infected by the HPV virus. Some of the following are included: Those with a weakened immune system, Those with cuts, injuries, and skin infections (especially on the feet), People who have regular contact with someone who has warts, Children and teenagers.
- #30 Plantar Warts: Causes and Treatments | The Pediatric Orthopedic CenterAccessibility ToolsIncrease TextDecrease TextGrayscaleHigh ContrastNegative ContrastLight BackgroundLinks UnderlineReadable FontResethttps://pediatricorthopedics.com/plantar-warts-causes-and-treatments/
Anyone can get plantar warts, including children. These growths are relatively common, and between 10% and 20% of children and teenagers have them. […] Warts of all kinds develop from the human papillomavirus (HPV), when the virus enters a break in the skin and causes an infection. […] Plantar warts are benign warts on the soles, heels, or balls of your feetâthe plantar surfaces. […] Because the plantar wart is caused by the human papillomavirus, it is contagious. […] Like all warts, plantar wart causes come down to one situation: the human papillomavirus getting into the skin through cuts or scrapes. […] Plantar warts spread from direct skin-to-skin contact with the virus, by touching the wart and another part of the body, or by sharing clothing (socks and shoes) or towels. […] Since viruses like wet, warm environments, your child can pick up the virus at a public pool, locker room shower (or your home shower), or sauna or steam roomâmoist places where your childâs feet will be bare. […] But the plantar warts can be caused by walking barefoot on infected surfaces in general.
- #31 Why Does My Child Have Plantar Warts?: Washington Foot & Ankle Sports Medicine: Podiatryhttps://www.rundoctor.com/blog/why-does-my-child-have-plantar-warts
Plantar warts are caused by a very common virus. Its a form of the human papillomavirus (HPV), but its not one of the sexually transmitted varieties. […] Children are more likely to develop plantar warts than adults because adults develop more resistance to the virus over time.
- #32 Plantar Warts: Epidemiology, Pathophysiology, and Clinical Managementhttps://www.degruyterbrill.com/document/doi/10.7556/jaoa.2018.024/html?lang=en&srsltid=AfmBOorKydgR6MZAMtohtVamHILQMycBeOTGNEOk-IH0BbfEYUsx6zUp
Plantar warts have a very high viral load, which increases the rate of viral shedding and the likelihood of contaminating adjacent body surfaces, inanimate communal surfaces, or close contacts. […] Immunocompromised patients have higher rates of plantar warts, along with increased severity and duration of the lesions.
- #33 Plantar Warts Treatment and Causeshttps://intermountainhealthcare.org/blogs/plantar-warts-treatment-and-causes
Most warts are fairly harmless. Theyre skin growths caused by a strain of the human papillomavirus (HPV); however, plantar warts arent the same as genital warts. Instead, this virus settles into the weight-bearing pads of your feet, which causes a wart. […] While anyone can get a wart, those with weakened immune systems are most at risk.
- #34 Plantar Warts: Epidemiology, Pathophysiology, and Clinical Managementhttps://www.degruyter.com/document/doi/10.7556/jaoa.2018.024/html?lang=en
Two of the most significant risk factors for developing plantar warts are (1) having a preexistent wart and (2) having close contact with someone who has a preexistent wart. […] Plantar warts have a very high viral load, which increases the rate of viral shedding and the likelihood of contaminating adjacent body surfaces, inanimate communal surfaces, or close contacts. […] Walking barefoot also increases the likelihood of contacting HPV, especially if one walks barefoot in an area where others have walked barefoot, such as pool decks or communal showers. […] Immunocompromised patients have higher rates of plantar warts, along with increased severity and duration of the lesions.
- #35 Common Causes of Plantar Warts | Ripepi Foot & Ankle Clinics, Inc.https://www.stopfootpaintoday.com/blog/common-causes-of-plantar-warts.cfm
Plantar warts are caused by the Human Papilloma (HP) virus. The virus invades your foot through cracks and breaks in the skin and thrives in warm, moist environments. That is why our shoes, public pools, and locker rooms are perfect breeding grounds for plantar warts. […] Walking barefoot in public places. […] Your feet sweat a lot. […] Calloused or broken skin on the bottom of your foot. […] A family member has plantar warts. […] Weak immune system. […] The Human Papilloma (HP) virus loves warm, moist areas, so sweaty feet increase the likelihood of getting a plantar wart. […] Having broken and damaged skin on the bottom of your feet will allow the HP virus to enter the skin and allow a plantar wart to start. […] Families share showers, so if a family member has plantar wart, they can spread them on the shower floor without the others being aware that there is a problem. […] Viral warts affect children and teens more than adults because their immune systems have not developed the antibodies to fight strains of HP virus that cause warts.
- #36 Plantar Warts: Epidemiology, Pathophysiology, and Clinical Managementhttps://www.degruyter.com/document/doi/10.7556/jaoa.2018.024/html?lang=en
Two of the most significant risk factors for developing plantar warts are (1) having a preexistent wart and (2) having close contact with someone who has a preexistent wart. […] Plantar warts have a very high viral load, which increases the rate of viral shedding and the likelihood of contaminating adjacent body surfaces, inanimate communal surfaces, or close contacts. […] Walking barefoot also increases the likelihood of contacting HPV, especially if one walks barefoot in an area where others have walked barefoot, such as pool decks or communal showers. […] Immunocompromised patients have higher rates of plantar warts, along with increased severity and duration of the lesions.
- #37 Plantar Warts: Causes, Prevention, and Treatment – NailKnowledgehttps://nailknowledge.org/blog/plantar-warts-causes-prevention-and-treatment
Plantar warts begin when a sneaky virus called human papillomavirus (HPV) decides to hitch a ride. HPV invades the skin through tiny cuts or abrasions, usually on the soles of your feet. […] They spread through direct contact, so places like communal showers, pools, and gym floors are hotbeds for transmission. […] If your immune system isn’t at its A-gameâwhether due to illness, stress, or other factorsâyouâre more vulnerable. […] Younger people are more prone to warts because their immune systems haven’t built up resistance to HPV. […] Spending time in locker rooms and around communal showers? It’s a prime spot for picking up the virus.
- #38 What Causes Plantar Warts? | Foot and Ankle Specialty Centershttps://www.footankleaz.com/blog/foot-health/plantar-wart-causes/
Plantar warts show up on the bottom of your feet and can make walking feel like stepping on a pebble all day long. […] They show up when a virus gets into the skin on the bottom of your foot. This happens more often than you think. […] The virus that causes plantar warts can live on those floors. If you walk barefoot, the virus can sneak into your skin through tiny cuts or scratches. […] The virus spreads through skin contact. […] Bad skin is among the plantar wart causes. If the bottom of your foot is cracked or has cuts, even small ones, it gives the virus an easy way in. […] Your immune system can actually help the plantar wart causes. Some peoples bodies are better at fighting off viruses than others. […] Wet, sweaty feet trapped inside tight shoes make a perfect home for the virus.
- #39 Understanding Plantar Warts: Those Unwanted Visitors On Your Feet – Northern Ankle Foot Associateshttps://northernanklefoot.com/understanding-plantar-warts-those-unwanted-visitors-on-your-feet/
A plantar wart is a small, hard growth that occurs on the foot, most commonly on the soles Plantar warts are induced by the human papillomavirus (HPV), which enters the body through small cuts or breaks in the skin. […] The plantar wart is often contracted while barefoot walking on unclean surfaces or littered ground where the virus lurks. The virus is sustained in warm, moist environments. […] In addition to HPV, several other risk factors may develop plantar warts, including: Age: Children and teenagers are more susceptible to plantar warts due to activities that lead to being barefoot. […] Foot injuries: If you have a cut or abrasion on your foot, you may be more likely to develop warts. […] Sweaty feet: Moist, sweaty feet are more prone to developing plantar warts. […] Poor hygiene: Not washing your feet regularly or wearing dirty socks and shoes may increase your risk of developing plantar warts.
- #40 Plantar Warts: Epidemiology, Pathophysiology, and Clinical Managementhttps://www.degruyter.com/document/doi/10.7556/jaoa.2018.024/html?lang=en
Once in contact with a host, HPV gains entry to the basal epithelial layer, where actively dividing stem cells are located. […] After infection, if the virus is not cleared, the host basal keratinocyte is stimulated to divide and replicate viral DNA via HPV E1 and E2 proteins. […] Once infection occurs, 3 outcomes are possible: clearance of the infection with resultant immunity to that particular HPV type, latent infection, or clinically manifested infection as a plantar wart. […] The induction of cellular replication throughout the process of viral genome amplification leads to the hyperkeratinized papule that constitutes a plantar wart. […] Plantar warts tend to develop at areas of increased pressure on the sole of the foot, including the heel and metatarsal heads. […] Such pressure points are regions of increased microtrauma to the epidermal barrier, which increases the likelihood of HPV invasion.
- #41 Plantar Warts: Causes, Symptoms & Treatment | Resurgens Orthopaedicshttps://www.resurgens.com/education/plantar-warts-verruca-plantaris
Plantar warts occur when the human papillomavirus (HPV) enters the body through cuts or breaks in the skin and causes growths to erupt on the soles of the feet. […] HPV is spread by direct and indirect contact from an infected host. To avoid transmission, it is important to avoid direct contact with infected surfaces. Examples of risky surfaces include communal changing rooms and shower floors and benches. Additionally, avoid sharing shoes and socks. Contact with anyone with HPV can increase your risk of spreading the infection. […] There are two distinct types of plantar warts. The first are solitary warts that appear on their own. The second are mosaic warts which appear as group clusters on the foot. Mosaic warts can be more difficult to treat.
- #42 Warts, verrucas, human papillomavirus infectionhttps://dermnetnz.org/topics/viral-wart
Warts are due to infection by the human papillomavirus (HPV), a double-stranded DNA virus. There are more than 150 known HPV types, only some of which infect the skin, giving rise to a variety of clinical presentations. […] The most common HPV types infecting the skin are types 1, 2, 3, 4, 10, 27, 29, and 57. […] HPV is spread by direct skin-to-skin contact or autoinoculation; if a wart is scratched or picked, a wart may develop under the fingernail (subungual wart) or virus may be spread to another area of skin. […] Plantar warts (verruca plantaris) include tender inwardly growing myrmecia on the sole caused by HPV 1, and clusters of superficial less painful mosaic warts due to HPV 2. […] Myrmecial warts are typically tender with lateral and direct pressure, are surrounded by yellow hyperkeratotic callus-like skin showing accentuated skin markings, but with discontinuation of the skin lines through the actual wart. […] Plantar epidermoid cysts are associated with HPV 60 infection of the eccrine ducts.
- #43 Plantar Wart Removal, Treatment, Causes, Contagious, Remedies & Symptomshttps://www.emedicinehealth.com/plantar_warts/article_em.htm
Warts are caused by an infection of the skin by human papillomavirus (HPV), which is the most common viral infection of the skin. […] The HPV types 57, 27, and 1a account for most plantar warts. The virus gains access to the skin through direct contact. […] It is presumed that inoculation of the skin occurs in places likely to be contaminated by others with plantar warts, like communal showers. […] Once infected by HPV, spontaneous resolution seems to depend on the development of immune lymphocytes that destroy the virus-infected cells. […] HPV infections are ubiquitous infections, with at least one-half of adults infected during their lifetime. […] There are at least 120 different types of human papillomavirus (HPV), and certain types tend to infect specific anatomical areas, like the plantar surface of the foot. […] Risk factors for the development of plantar warts include use of public showers, skin trauma, and weakened immune system because of certain medications used or illness.
- #44 Plantar Warts: Causes, Symptoms & Treatment | The Feet People Podiatryhttps://www.thefeetpeople.com.au/symptoms-we-treat/plantar-warts/
The HPV virus that causes plantar warts is very contagious and can easily spread to other areas of your body as well as other people, through direct contact or indirect transmission e.g. a floor in a communal locker room. […] Unfortunately, once you contract the virus, it will stay in your system for life, even if there is no current physical evidence of plantar warts. This means there is always a chance that warts will continue to grow in the area.
- #45https://bpac.org.nz/bpj/2014/december/plantar-warts.aspx
Plantar warts are caused by cutaneous infection with the human papillomavirus (HPV). There are numerous types of HPV which manifest in different ways. Plantar warts are generally caused by HPV-1, 4, 27 and 57 […] HPV is transmitted by skin contact or contact with surfaces touched by other people with the virus. HPV can be present for weeks or years before the appearance of a wart, and persists for life, even after the wart has resolved. This may lead to recurrence at the same site, e.g. if a person who is carrying the virus becomes immunosuppressed; plantar warts are very prevalent in organ transplant recipients. […] In rare cases (and particularly in people who are immunosuppressed), warts of prolonged duration have been reported to undergo malignant transformation to squamous cell carcinoma or plantar verrucous carcinoma.
- #46 Plantar Warts and Palmar Warts: Treatments and Causeshttps://www.webmd.com/skin-problems-and-treatments/plantar-warts-palmar-warts
Plantar warts and palmar warts are noncancerous skin growths caused by a viral infection in the top layer of the skin. The culprit is a strain of virus called human papillomavirus (HPV). […] A person’s risk of getting a wart varies. Those with a weakened immune system are more likely to get it. But those with healthy immune systems can also develop warts. […] Some people mistakenly think plantar warts or palmar warts are malignant. But they aren’t harmful.
- #47https://bpac.org.nz/bpj/2014/december/plantar-warts.aspx
Plantar warts are caused by cutaneous infection with the human papillomavirus (HPV). There are numerous types of HPV which manifest in different ways. Plantar warts are generally caused by HPV-1, 4, 27 and 57 […] HPV is transmitted by skin contact or contact with surfaces touched by other people with the virus. HPV can be present for weeks or years before the appearance of a wart, and persists for life, even after the wart has resolved. This may lead to recurrence at the same site, e.g. if a person who is carrying the virus becomes immunosuppressed; plantar warts are very prevalent in organ transplant recipients. […] In rare cases (and particularly in people who are immunosuppressed), warts of prolonged duration have been reported to undergo malignant transformation to squamous cell carcinoma or plantar verrucous carcinoma.
- #48 Plantar Warts: Epidemiology, Pathophysiology, and Clinical Managementhttps://www.degruyterbrill.com/document/doi/10.7556/jaoa.2018.024/html?lang=en&srsltid=AfmBOorKydgR6MZAMtohtVamHILQMycBeOTGNEOk-IH0BbfEYUsx6zUp
Plantar warts have a very high viral load, which increases the rate of viral shedding and the likelihood of contaminating adjacent body surfaces, inanimate communal surfaces, or close contacts. […] Immunocompromised patients have higher rates of plantar warts, along with increased severity and duration of the lesions.
- #49https://bpac.org.nz/bpj/2014/december/plantar-warts.aspx
Plantar warts are caused by cutaneous infection with the human papillomavirus (HPV). There are numerous types of HPV which manifest in different ways. Plantar warts are generally caused by HPV-1, 4, 27 and 57 […] HPV is transmitted by skin contact or contact with surfaces touched by other people with the virus. HPV can be present for weeks or years before the appearance of a wart, and persists for life, even after the wart has resolved. This may lead to recurrence at the same site, e.g. if a person who is carrying the virus becomes immunosuppressed; plantar warts are very prevalent in organ transplant recipients. […] In rare cases (and particularly in people who are immunosuppressed), warts of prolonged duration have been reported to undergo malignant transformation to squamous cell carcinoma or plantar verrucous carcinoma.
- #50 Warts on the feet (plantar warts): Causes, prevention, and treatmenthttps://www.medicalnewstoday.com/articles/warts-on-feet
Plantar warts are warts that grow on the feet. They are noncancerous skin growths that result from infection with the human papillomavirus (HPV). […] Plantar warts result from HPV infections. Warts occur when the virus enters skin cells through cuts or injuries on the bottom of the foot. The virus makes the skin cells grow more quickly, which causes a thickened bump, or wart, to form. […] HPV is very common and contagious, with hundreds of variations. However, only a few types of HPV cause plantar warts. The viruses perform best in warm, moist places such as communal areas near swimming pools, and they are most likely to infect moist or injured skin.
- #51 Plantar Warts: Epidemiology, Pathophysiology, and Clinical Managementhttps://www.degruyter.com/document/doi/10.7556/jaoa.2018.024/html?lang=en
Two of the most significant risk factors for developing plantar warts are (1) having a preexistent wart and (2) having close contact with someone who has a preexistent wart. […] Plantar warts have a very high viral load, which increases the rate of viral shedding and the likelihood of contaminating adjacent body surfaces, inanimate communal surfaces, or close contacts. […] Walking barefoot also increases the likelihood of contacting HPV, especially if one walks barefoot in an area where others have walked barefoot, such as pool decks or communal showers. […] Immunocompromised patients have higher rates of plantar warts, along with increased severity and duration of the lesions.