Materiały źródłowe

• #1 Prognostic models for predicting insomnia treatment outcomes: A systematic review

  https://pmc.ncbi.nlm.nih.gov/articles/PMC11687218/

  To identify and critically evaluate models predicting insomnia treatment response in adult populations. […] Prediction models may be a useful tool to assist clinicians in selecting the optimal treatment strategy for patients with insomnia. However, no externally validated models currently exist. These results highlight an important gap in the literature and underscore the need for the development and validation of modern, methodologically rigorous models. […] Given that insomnia treatment response varies widely depending on the individual, prediction models may be a promising tool to help clinicians identify which treatments are most likely to benefit a particular patient. […] Accurate prediction models for insomnia treatment outcomes could have significant clinical benefits, including improved patient care, reduced insomnia-related healthcare costs, and minimizing the risk of adverse events associated with inappropriate treatment selection.

• #2 Prognostic models for predicting insomnia treatment outcomes: A systematic review – PubMed

  https://pubmed.ncbi.nlm.nih.gov/38141325/

  Objective: To identify and critically evaluate models predicting insomnia treatment response in adult populations. […] Prediction models may be a useful tool to assist clinicians in selecting the optimal treatment strategy for patients with insomnia. However, no externally validated models currently exist. These results highlight an important gap in the literature and underscore the need for the development and validation of modern, methodologically rigorous models.

• #2 Prognostic models for predicting insomnia treatment outcomes: A systematic review

  https://pmc.ncbi.nlm.nih.gov/articles/PMC11687218/

  While there are a variety of insomnia treatments available, their effectiveness can vary substantially depending on the individual patient. Prediction models may be a useful tool to assist clinicians in selecting the optimal treatment strategy for patients with insomnia, however, external validation studies are needed to determine the utility and generalizability of the currently published models. […] These results highlight an important gap in the literature and underscore the need for modern, methodologically rigorous models. Future research efforts focused on developing and validating such models could enable clinicians to tailor treatment strategies to the unique needs of each patient, potentially leading to better outcomes and improved quality of life for individuals suffering from insomnia.

• #3 Prognostic models for predicting insomnia treatment outcomes: A systematic review – PubMed

  https://pubmed.ncbi.nlm.nih.gov/38141325/

  Objective: To identify and critically evaluate models predicting insomnia treatment response in adult populations. […] Prediction models may be a useful tool to assist clinicians in selecting the optimal treatment strategy for patients with insomnia. However, no externally validated models currently exist. These results highlight an important gap in the literature and underscore the need for the development and validation of modern, methodologically rigorous models.

• #4 Insomnia and its treatments—trend analysis and publication profile of randomized clinical trials | npj Biological Timing and Sleep

  https://www.nature.com/articles/s44323-024-00014-0

  This study aimed to describe the publication profile of randomized controlled trials (RCTs) for insomnia. […] The majority of the available RCTs are on non-pharmacological interventions, particularly CBT-I (mostly in the 2000s) and dCBT-I (mostly in the last decade), although presenting a reduced methodological quality in comparison to pharmacological interventions. […] The number of RCTs performed related to insomnia has been growing rapidly, reflecting the growing number of new therapeutic options for insomnia that are being proposed, developed, and made available. […] The current study demonstrated that the number of RCTs for treatments for insomnia has been growing significantly. […] In this regard, an interesting finding is the surge in the number of RCTs about dCBT-I, the intervention with the most published studies (n=35).

• #5 Insomnia and its treatments—trend analysis and publication profile of randomized clinical trials | npj Biological Timing and Sleep

  https://www.nature.com/articles/s44323-024-00014-0

  While our data showed a reduction in the proportion of these over the past decades, there is a general consensus that drug research needs to be expanded in this area to fill gaps in the literature about pharmacological treatments for insomnia. […] The lack of RCTs is not only restricted to the drug categories being assessed, but also to the population being studied in these trials; for example, there are few RCTs for insomnia treatments in specific populations, such as children, older adults, and people with comorbidities, as has been reported in previous studies. […] The average methodological compliance rate was significantly higher among RCTs of pharmacological interventions in comparison to non-pharmacological ones. […] This reinforces the need for more robust methodological control of non-pharmacological interventions for insomnia. […] In conclusion, the output of RCTs on interventions for the treatment of insomnia has been growing steadily.

• #6

  https://link.springer.com/article/10.1007/s13167-024-00369-1

  Insomnia persists as a prevalent sleep disorder among middle-aged and older adults, significantly impacting quality of life and increasing susceptibility to age-related diseases. […] Current treatment regimens for both patient groups yield unsatisfactory outcomes. […] Consequently, investigating the neurophysiological distinctions between P-IN and O-IN is imperative for devising novel precision interventions aligned with primary prediction, targeted prevention, and personalized medicine (PPPM) principles. […] These findings provide valuable insights into the microbiota-mediated mechanism of O-IN versus P-IN onset. GM profiling may thus serve as a tailored stratification criterion, enabling the identification of women at risk for specific insomnia subtypes and facilitating the development of integrated microbiota-based predictive diagnostics, targeted prevention, and personalized therapies, ultimately enhancing clinical effectiveness.

• #7

  https://link.springer.com/article/10.1007/s13167-024-00369-1

  This comprehensive approach holds promise for identifying women at risk of P-IN or O-IN by screening for specific GM profiles, thereby facilitating the development of targeted prevention and personalized intervention strategies based on GM modulation. […] The distinct GM composition observed in P-IN and O-IN patients suggests that these two insomnia subtypes are likely to have different biological bases, leading to a promising possibility to discriminate between these two forms of insomnia and offering valuable insights to improve the efficacy of current pharmacological treatments for P-IN through GM modulation (dietary or lifestyle-based). […] By leveraging the principles of PPPM, diagnostic tools based on the screening for specific GM profiles could be developed to identify women at risk of P-IN or O-IN, thereby improving outcomes and quality of life for those affected.

• #8 Insomnia and the risk of depression: a meta-analysis of prospective cohort studies | BMC Psychiatry | Full Text

  https://bmcpsychiatry.biomedcentral.com/articles/10.1186/s12888-016-1075-3

  Observational studies suggest that insomnia might be associated with an increased risk of depression with inconsistent results. […] This meta-analysis indicates that insomnia is significantly associated with an increased risk of depression, which has implications for the prevention of depression in non-depressed individuals with insomnia symptoms. […] The pooled estimates (RR=2.27; 95 % CI: 1.89-2.71) indicated that participants with insomnia, compared to those free of it, experienced more than two-fold risk to develop depression. […] Our findings were approximately consistent with those from the meta-analysis by Baglioni et al. in 2011, which also showed that sleep difficulty was significantly associated with depression. […] The current meta-analysis showed that the increased risk was more pronounced for participants from the United States than for European participants.

• #9 Insomnia and the risk of depression: a meta-analysis of prospective cohort studies | BMC Psychiatry | Full Text

  https://bmcpsychiatry.biomedcentral.com/articles/10.1186/s12888-016-1075-3

  Based on our findings, we suggest that future research in this field is warranted, especially the long-term prospective cohort studies about the association between individual insomnia symptoms and depression. […] In conclusion, this meta-analysis supports the hypothesis that insomnia is associated with an increased risk of depression.

• #10 Insomnia and Objectively Measured Sleep Disturbances Predict Treatment Outcome in Depressed Patients Treated With Psychotherapy or Psychotherapy-Pharmacotherapy Combinations

  https://www.psychiatrist.com/jcp/insomnia-objectively-measured-sleep-disturbances-predict/

  Insomnia and objectively measured sleep disturbances predict poor treatment outcomes in patients with major depressive disorder (MDD). […] The present study is a secondary analysis that examines the degree to which insomnia, objective sleep disturbances, or their combination predicts depression remission following pharmacotherapy and/or psychotherapy treatment. […] Prolonged sleep latency alone (OR = 3.53; 95% CI, 1.28-9.73) or in combination with insomnia (OR = 2.11; 95% CI, 1.13-3.95) predicted increased risk of nonremission. In addition, insomnia and sleep duration individually and in combination were each associated with a significantly increased risk of nonremission (P values .05). […] Findings suggest that objectively measured prolonged sleep latency and short sleep duration independently or in conjunction with insomnia are risk factors for poor depression treatment outcome.

• #11 Investigation of screening questions to identify insomnia in cancer patients | Scientific Reports

  https://www.nature.com/articles/s41598-024-69086-z

  The high prevalence of insomnia in cancer patients leads to a significant reduction in the quality of life of those affected. […] Insomnia in cancer patients is a common and serious symptom. […] The literature consistently shows evidence of a strong association between sleep disorders and cancer disease of various entities. […] Sleep disorders and the resulting daytime tiredness lead to a severely impaired quality of life for patients. […] This evidence highlights the importance of a screening procedure implemented in the clinical care routine to identify cancer patients with sleep disorders. […] However, there are references to the fact that these screening practices are not widely used in clinical practice. […] But early detection remains necessary in order to identify modifiable factors as early as possible, which then allows offering patients appropriate treatment options.

• #12 Investigation of screening questions to identify insomnia in cancer patients | Scientific Reports

  https://www.nature.com/articles/s41598-024-69086-z

  A systematic literature review by Bttner-Teleag et al. points to the effectiveness of alternative non-drug treatments of cancer patients with insomnia; especially early interventions with personalized pathways and web-based telehealth programs. […] The implementation of a close-meshed screening process could potentially reduce the risk of underdiagnosis of insomnia in everyday clinical practice. […] A finely differentiated approach to the detection of insomnia therefore remains necessary in order to be able to assess and treat patients according to their needs. […] We therefore suggest that patients who show a positive sleep disorder question should be assessed by ISI survey as soon as possible.

• #13 Association between life satisfaction, sleep disturbance and mental health problems among the migrant older adults with children: a conditional process analysis based on per capita bedroom area | BMC Geriatrics | Full Text

  https://bmcgeriatr.biomedcentral.com/articles/10.1186/s12877-025-05957-y

  Life satisfaction was negatively associated with mental health problems, and sleep disturbance could mediate their association. […] Furthermore, the direct effect of life satisfaction on mental health problems and the indirect effect of sleep disturbance in the relationship were moderated by PCBA, but it only moderated the direct effect and the second indirect link (sleep disturbance-mental health problems) of the mediating effect. […] Life satisfaction had negative effect on mental health problems. PCBA moderated the direct effect of life satisfaction on mental health problems and the mediating effect of sleep disturbance on mental health problems. […] This study illustrated that the association between life satisfaction and mental health problems was partially mediated by sleep disturbance.

• #14 Association between life satisfaction, sleep disturbance and mental health problems among the migrant older adults with children: a conditional process analysis based on per capita bedroom area | BMC Geriatrics | Full Text

  https://bmcgeriatr.biomedcentral.com/articles/10.1186/s12877-025-05957-y

  PCBA was found could moderate the direct effect of life satisfaction on mental health problems and the second half of the indirect effect from sleep disturbance to mental health problems. […] The direct effect of life satisfaction on mental health problems and the effect of sleep disturbance on mental health problems were stronger at the low level of PCBA. […] To summarize, life satisfaction was negatively associated with mental health problems among the MOAC in Weifang, China; sleep disturbance played a mediating role in the relationship between life satisfaction and mental health problems; the direct effect of life satisfaction on mental health problems and the indirect effect between sleep disturbance and mental health problems were moderated by PCBA.

Zobacz więcej