Materiały źródłowe

• #1 Azthena logo with the word Azthena

  https://www.news-medical.net/health/What-is-Pneumonitis.aspx

  Pneumonitis is an inflammatory respiratory condition caused by acute or chronic exposure to irritating antigens in the environment. […] The severity of symptoms, clinical presentation, and prognosis can vary greatly between patients, as these factors of the disease can depend on the duration of exposures as well as specific characteristics of the antigen. The acute form of hypersensitivity pneumonitis occurs within hours or days of exposure to the antigen and is associated with symptoms such as fever, dyspnea, cough, malaise, and asthenia. These symptoms persist for about a week following exposure to the causative agent. […] Subacute pneumonitis is a result of longer exposure to the antigen. Symptoms will include productive cough, asthenia, and dyspnea. This form is generally difficult to differentiate from the acute form.

• #2 Pneumonitis – Wikipedia

  https://en.wikipedia.org/wiki/Pneumonitis

  Pneumonitis describes general inflammation of lung tissue. Possible causative agents include radiation therapy of the chest, exposure to medications used during chemotherapy, the inhalation of debris (e.g., animal dander), aspiration, herbicides or fluorocarbons and some systemic diseases. If unresolved, continued inflammation can result in irreparable damage such as pulmonary fibrosis. […] Physical manifestations of Pneumonitis range from mild cold-like symptoms to respiratory failure. Most frequently, those with pneumonitis experience shortness of breath, and sometimes a dry cough. Symptoms usually appear a few hours after exposure and peak at approximately eighteen to twenty-four hours. […] Without proper treatment, pneumonitis may become chronic pneumonitis, resulting in fibrosis of the lungs and its effects: Difficulty breathing, Food aversion, Lethargy. End-stage fibrosis and respiratory failure eventually lead to death in cases without proper management of chronic pneumonitis.

• #3 Pneumonitis: Causes, Symptoms, Diagnosis & Treatment

  https://my.clevelandclinic.org/health/diseases/24810-pneumonitis

  Pneumonitis causes inflammation in the alveoli in your lungs. […] Pneumonitis (noo-MOHN-eye-tus) is general inflammation in your lungs that can affect how well you breathe and cause other bodily symptoms. […] There are different types of pneumonitis inflammation. They include: Acute. Inflammation develops suddenly and only lasts a little while. […] Subacute. Inflammation progresses gradually and steadily. […] Chronic. Inflammation unfolds over a long period and becomes ongoing. […] Yes, pneumonitis is serious. Long-term exposure to irritants that cause pneumonitis may cause permanent lung damage. […] Early signs of pneumonitis include common cold-like symptoms, including: Shortness of breath (dyspnea). […] Chest pain. […] A cough that doesnt bring up mucus or phlegm (dry cough).

• #3 Pneumonitis: Causes, Symptoms, Diagnosis & Treatment

  https://my.clevelandclinic.org/health/diseases/24810-pneumonitis

  Other symptoms may include: Fatigue. […] Fever. […] Flushed skin. […] Sweating. […] Chronic pneumonitis symptoms may include: Breathing in short, shallow spurts. […] Cyanosis. […] Unintentional weight loss. […] Long-term exposure to irritants that cause pneumonitis may cause serious, irreversible lung damage. […] Chronic pneumonitis damage is usually permanent. However, medication and therapy can help reduce the severity of your symptoms. […] Milder cases of pneumonitis may go away within a few days or months once you and a healthcare provider identify the irritant and take the proper steps to avoid it. […] Severe cases of pneumonitis usually don’t go away. […] It depends. With proper diagnosis and treatment, you can fully recover from acute and subacute cases of pneumonitis. You usually can’t make a full recovery from severe cases of pneumonitis. However, medication and therapy can help make your symptoms more manageable.

• #4 Pneumonitis – Symptoms and causes – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/pneumonitis/symptoms-causes/syc-20352623

  Trouble breathing, and often a dry cough, are the most common symptoms of pneumonitis. […] Symptoms of pneumonitis may develop quickly or slowly and can worsen over time. At times symptoms may suddenly get worse or better. Also, symptoms vary greatly among people with the condition and include: […] Trouble breathing. […] Dry cough that usually doesn’t bring up any mucus. […] Extreme tiredness. […] Loss of appetite. […] Fever. […] Joint and muscle pain. […] Headache. […] Weight loss. […] If pneumonitis is not detected or not treated, you may gradually develop lung damage that can’t be reversed. […] Ongoing inflammation of the thin tissue lining each air sac causes scarring and makes the air sacs less flexible. They become stiff like a dried sponge. This is called pulmonary fibrosis. In severe cases, pulmonary fibrosis can cause high blood pressure in the lungs, right-sided heart failure, respiratory failure or death.

• #5 Pneumonitis | UM Health-Sparrow

  https://www.uofmhealthsparrow.org/departments-conditions/conditions/pneumonitis

  Trouble breathing, and often a dry cough, are the most common symptoms of pneumonitis. […] Symptoms of pneumonitis may develop quickly or slowly and can worsen over time. At times symptoms may suddenly get worse or better. Also, symptoms vary greatly among people with the condition and include: […] Trouble breathing. […] Dry cough that usually doesn’t bring up any mucus. […] Extreme tiredness. […] Loss of appetite. […] Fever. […] Joint and muscle pain. […] Headache. […] Weight loss. […] If you have trouble breathing, go to the emergency department at a hospital right away or, in the U.S., call 911. […] Some people who have radiation therapy to the chest, such as for breast or lung cancer, may get pneumonitis. Pneumonitis also can happen after whole-body radiation therapy that’s done to prepare a person for a bone marrow transplant. Symptoms usually appear in the first few months after radiation treatment is finished.

• #6 Pneumonitis | Beacon Health System

  https://www.beaconhealthsystem.org/library/diseases-and-conditions/pneumonitis?content_id=CON-20303988

  Trouble breathing, and often a dry cough, are the most common symptoms of pneumonitis. […] Symptoms of pneumonitis may develop quickly or slowly and can worsen over time. At times symptoms may suddenly get worse or better. Also, symptoms vary greatly among people with the condition and include: Trouble breathing. Dry cough that usually doesn’t bring up any mucus. Extreme tiredness. Loss of appetite. Fever. Joint and muscle pain. Headache. Weight loss. […] If pneumonitis is not detected or not treated, you may gradually develop lung damage that can’t be reversed. […] Ongoing inflammation of the thin tissue lining each air sac causes scarring and makes the air sacs less flexible. They become stiff like a dried sponge. This is called pulmonary fibrosis. In severe cases, pulmonary fibrosis can cause high blood pressure in the lungs, right-sided heart failure, respiratory failure or death.

• #7 Hypersensitivity Pneumonitis Symptoms and Diagnosis | American Lung Association

  https://www.lung.org/lung-health-diseases/lung-disease-lookup/hypersensitivity-pneumonitis/symptoms-diagnosis

  Hypersensitivity pneumonitis is typically divided into two types based on how long you have been affected and how severe your symptoms are. […] An attack of acute hypersensitivity pneumonitis usually occurs four to six hours after a short period of intense exposure to the substance you are allergic to. You may feel as if you have caught the flu when an acute attack occurs. Common symptoms include fever, chills, muscle aches, headache and cough. These symptoms may last for as little as 12 hours to a few days and will resolve if further exposure is avoided. […] Chronic hypersensitivity pneumonitis develops after numerous or continuous exposures to small amounts of the allergen. Symptoms may include shortness of breath, tiredness, coughing that lasts weeks or months and weight loss that gets progressively worse. Over time, some people with chronic hypersensitivity pneumonitis develop clubbing of fingers and toes and irreversible pulmonary fibrosis.

• #8 Pneumontis | Lung Care | Bon Secours

  https://www.bonsecours.com/health-care-services/lung-care-pulmonology/conditions/pneumonitis

  Pneumonitis symptoms generally appear four to six hours after breathing in an irritating substance. Initially, you may experience symptoms such as: Fever, Chills, Muscle or joint pain, Headaches. […] Symptoms of chronic pneumonitis include: Dry cough, Fatigue, Tightening in your chest, Loss of appetite, Unintentional weight loss. […] If left untreated, pneumonitis can cause severe, irreversible lung damage. Chronic inflammation can lead to pulmonary fibrosis, which, in severe cases, can cause heart failure, respiratory failure, and death.

• #9 Hypersensitivity pneumonitis: MedlinePlus Medical EncyclopediaLock

  https://medlineplus.gov/ency/article/000109.htm

  Hypersensitivity pneumonitis is inflammation of the lungs due to breathing in dust, fungus, molds, or other substances. […] Long-term exposure can lead to lung inflammation and acute lung disease. Over time, the acute condition turns into long-lasting (chronic) lung disease. […] Symptoms often occur 4 to 8 hours after you have left the area where the triggering substance is found. This makes it hard to figure out what has caused the disease. Your symptoms may get better before you go back to the area where you were exposed to the substance. In the chronic phase of the condition, the symptoms are more constant and less affected by exposure to the substance. […] Symptoms after acute exposure may include: Chills, Cough, Fever, Malaise (feeling ill), Shortness of breath. […] Symptoms of chronic hypersensitivity pneumonitis may include: Breathlessness, especially with activity, Cough, often dry, Loss of appetite, Unintentional weight loss.

• #9 Hypersensitivity pneumonitis: MedlinePlus Medical EncyclopediaLock

  https://medlineplus.gov/ency/article/000109.htm

  Most symptoms go away when you avoid or limit your exposure to the material that caused the problem. The outlook is good if you prevent exposure during the acute stage. When it reaches the chronic stage, the disease might continue to progress, even if the offending substance is avoided. […] The chronic form of this disease may lead to pulmonary fibrosis. This is scarring of the lung tissue that often is not reversible. Eventually, end-stage lung disease and respiratory failure can occur. Some people might need lung transplantation at the end-stage of the disease.

• #10 Hypersensitivity Pneumonitis | Health & Human Services

  https://hhs.iowa.gov/epi-manual-guide-surveillance-investigation-and-reporting/environmental-disease/hypersensitivity

  Hypersensitivity pneumonitis is a syndrome of cough, dyspnea, and fatigue caused by sensitization and subsequent hypersensitivity to environmental antigens, frequently related to occupational exposures. […] Hypersensitivity pneumonitis is categorized as acute, subacute, or chronic disease. […] The acute form may develop 4-8 hours after heavy exposure to antigenic materials. Patients abruptly develop fever, chills, malaise, cough, chest tightness, dyspnea, and headache. Anorexia, nausea, and vomiting may also be present. Symptoms often resolve spontaneously within 12 hours to several days upon cessation of exposure. […] Patients with chronic low-level antigen exposure, which is more common with bird owners, often lack a history of acute episodes. Disease muscle wasting and weight loss. Clubbing has been observed in 50% of patients. Tachypnea, respiratory distress, and inspiratory crackles over lower lung fields often are present. Removing exposure sources results in only partial improvement. […] Acute disease is self-limiting with antigen avoidance; symptoms usually lessen within hours. Chronic disease has a more complicated prognosis: fibrosis is usually irreversible, but may not progress if the patient is no longer exposed to the antigen.

• #11 Pneumonitis: Symptoms, Causes, and More

  https://www.healthline.com/health/pneumonitis

  The first symptoms will usually appear within four to six hours after you breathe in the irritating substance. This is called acute pneumonitis. You might feel like you have the flu or another respiratory illness, with symptoms like: […] If you continue to be exposed, you can develop chronic pneumonitis, which is a more long-term condition. About 5 percent of people with pneumonitis will develop the chronic form. […] Symptoms of chronic pneumonitis include: dry cough, tightness in your chest, tiredness, appetite loss, unintentional weight loss. […] It’s important to get treated as soon as possible if you have pneumonitis. You’ll also want to identify and avoid the substances that triggered it. Once you have lung scarring, it’s not reversible, but if you catch pneumonitis early, you can stop and even reverse the condition.

• #12 Hypersensitivity Pneumonitis – Signs, Symptoms, and Complications – https://www.pacificahospital.com

  https://pacificahospital.com/can-breakfast-help-keep-us-thin-nutrition-science-is-tricky/

  Signs and symptoms vary between acute, subacute, and chronic types of hypersensitivity pneumonitis. If your condition is not diagnosed or well controlled by treatment, it can lead to irreversible lung damage and other potentially fatal complications. […] Signs and symptoms of acute, subacute, and chronic hypersensitivity pneumonitis may include flu-like illness including fever, chills, muscle or joint pain, or headaches; rales; cough; chronic bronchitis; shortness of breath; anorexia or weight loss; fatigue; fibrosis of the lungs; and clubbing of fingers or toes. […] Acute hypersensitivity pneumonitis is the most common form of this condition. It is thought to occur as a result of a short period of exposure to a large amount of causative substance. Symptoms usually occur within 9 hours of being exposed again to a substance that triggers your immune system. If an additional exposure does not occur, symptoms usually resolve after a few days. Subacute and chronic forms of hypersensitivity pneumonitis occur after multiple or continuous exposures to small amounts of a causative substance. Approximately 5 percent of patients develop chronic disease.

• #13 Azthena logo with the word Azthena

  https://www.news-medical.net/health/What-is-Pneumonitis.aspx

  In contrast, continuous exposure to a causative pathogen leads to chronic pneumonitis. This leads to constant inflammation and, over time, possibly irreversible pulmonary fibrosis. Chronic pneumonitis forms over several months or years and includes symptoms such as progressive dyspnea corresponding with wheezing and repeated episodes of low-grade fever.

• #14 Hypersensitivity Pneumonitis – Lung and Airway Disorders – Merck Manual Consumer Version

  https://www.merckmanuals.com/home/lung-and-airway-disorders/interstitial-lung-diseases/hypersensitivity-pneumonitis

  People may develop fever, cough, chills, and shortness of breath within 4 to 8 hours of re-exposure to substances to which they are sensitized. […] In acute hypersensitivity pneumonitis, people develop fever, cough, chills, and shortness of breath typically 4 to 8 hours after re-exposure to significant amounts of the causative organic dust. Wheezing is unusual. If people have no further contact with the antigen, symptoms usually diminish over a day or two, but complete recovery may take weeks. […] With chronic hypersensitivity pneumonitis, people repeatedly come in contact with an antigen over months to years, and lung scarring (fibrosis) may result. Shortness of breath during exercise, cough, and fatigue, may gradually progress over months or years. Eventually, the disease may lead to respiratory failure. Older people may be more prone to chronic, progressively worsening disease because they have been exposed to an antigen for a long period of time.

• #15 Hypersensitivity Pneumonitis – Pulmonary Disorders – Merck Manual Professional Edition

  https://www.merckmanuals.com/professional/pulmonary-disorders/interstitial-lung-diseases/hypersensitivity-pneumonitis

  Subacute disease falls between the acute and chronic forms and manifests either as cough, dyspnea, fatigue, and anorexia that develops over days to weeks or as acute symptoms superimposed on chronic ones. […] Pathologic changes of acute hypersensitivity pneumonitis are completely reversible if detected early and if antigen exposure is eliminated. Acute disease is self-limiting with antigen avoidance; symptoms usually lessen within hours. Chronic disease has a more complicated prognosis: fibrosis is usually irreversible but may not progress if the patient is no longer exposed to the antigen.

• #16 What is hypersensitivity pneumonitis? | Action for Pulmonary Fibrosis

  https://www.actionpf.org/information-support/hypersensitivity-pneumonitis

  In acute HP, symptoms develop within a few hours after intense or heavy exposure to the antigen. As well as breathlessness and cough, people may experience fever, chest tightness, fatigue and a headache. […] In chronic hypersensitivity pneumonitis, symptoms generally develop slowly over time and include breathlessness, cough, fatigue and weight loss. […] If acute HP is diagnosed early, it may resolve so long as there is no more exposure to the substance involved. But, in about a third of affected people, the lung disease can progress even when there is no further exposure to the antigen, resulting in scar tissue or fibrosis and irreversible damage to the lungs. […] Chronic hypersensitivity pneumonitis may get worse over time in a manner similar to Idiopathic Pulmonary Fibrosis.

• #17 Hypersensitivity pneumonitis (HP) | Life with PF

  https://lifewithpulmonaryfibrosis.com/ca/about-pulmonary-fibrosis/conditions/hypersensitivity-pneumonitis

  Hypersensitivity pneumonitis occurs in people after they breathe in certain substances in the environment that trigger the immune system and cause an allergic reaction. […] In chronic hypersensitivity pneumonitis, the lungs might become scarred, making it harder for oxygen to enter the blood, resulting in shortness of breath. […] The chronic response is marked by increasing cough, chronic bronchitis, shortness of breath, anorexia or weight loss, and lung fibrosis. The person may suffer permanent lung damage. […] Symptoms of chronic hypersensitivity pneumonitis may include: Shortness of breath, Increasing cough, Fatigue and weakness, Anorexia or weight loss, Lung fibrosis. […] For patients who have chronic hypersensitivity pneumonitis, symptoms may not fully resolve, and research suggests that people live for about 7 years if this is the case. Some people might face progressive of the disease, which means that the scarring might get worse over time. However, currently there is no way of predicting if, or how fast, this will happen. Some patients might not have changes in their symptoms, while other patients might experience a faster worsening of their symptoms. It is not known why some peoples disease progresses faster than others.

• #18 Interstitial Lung Diseases – Hypersensitivity Pneumonitis | NHLBI, NIH

  https://www.nhlbi.nih.gov/health/hypersensitivity-pneumonitis

  Symptoms of hypersensitivity pneumonitis can develop quickly or slowly and worsen over months or years. Also, your symptoms may suddenly get worse from time to time. Possible symptoms include: […] Without proper treatment, hypersensitivity pneumonitis can lead to pulmonary hypertension, permanent lung damage, or heart failure.

• #19 Pneumonitis: Symptoms, causes, and risk factors

  https://www.medicalnewstoday.com/articles/319451

  If left untreated, pneumonitis can be life-threatening, as it makes it harder for the heart to pump blood through the lungs. […] Pneumonitis can cause permanent damage to the lungs if it is not treated early. […] Pneumonitis can lead to severe complications if it is not treated, so people should be aware of the symptoms. […] If anyone is experiencing the symptoms of pneumonitis and notices them getting worse at any point, they should contact their doctor.

• #20 Hypersensitivity Pneumonitis – StatPearls – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK499918/

  As the disease progresses untreated (chronic HP), fibrosis occurs. Sparse poorly formed non-caseating granulomas and chronic inflammation are seen around the bronchioles with variable amounts of fibrosis. […] Early diagnosis and complete avoidance of inciting antigen results in total recovery of lung function in the majority of patients. Presence of pulmonary fibrosis portends a poor prognosis with a median survival of 3 to 5 years. Other factors such as older age, greater exposure, delayed diagnosis, cigarette smoking, the absence of lymphocytosis on BAL fluid, recurrent acute exacerbations, and pulmonary arterial hypertension have been associated with worse outcomes. […] If not promptly diagnosed and treated as detailed above, HP can progress to pulmonary fibrosis and progressive respiratory failure. Presence of fibrosis and honeycombing have been associated with higher mortality.

• #21 Pneumonitis in children – Children’s Health Pulmonary Medicine

  https://www.childrens.com/specialties-services/conditions/pneumonitis

  Pneumonitis (pneumonitis) in children occurs when the lung tissue is inflamed typically due to a virus. […] Pneumonitis is inflammation (swelling) of the tissue of a childs lungs. The inflammation occurs when an irritant enters the lungs. In most cases, these are inflammatory conditions that are not contagious. […] If your child has this condition, it is important that they receive treatment to avoid scarring of the lungs (known as fibrosis), which can result from untreated pneumonitis. […] Signs and symptoms of pneumonitis may include: Decreased appetite, Dry cough, Fatigue (extreme tiredness), Shortness of breath, Unintentional weight loss. […] Signs and symptoms of pneumonitis may include: Decreased appetite, Dry cough, Fatigue (extreme tiredness), Shortness of breath, Unintentional weight loss.

• #22 Pneumonia: Symptoms, Diagnosis, Treatment and Prevention | Nationwide Children’s Hospital

  https://www.nationwidechildrens.org/conditions/pneumonia

  Symptoms usually start out slow. They may get worse over the next few days. […] Sometimes, pneumonia can come on suddenly with a high fever, fast breathing, and coughing. Both viral and bacterial pneumonia can cause the child’s cough to last for weeks after the fever has stopped.

• #23 how to monitor for radiation pneumonitis – 1289829 | CancerGRACE

  https://cancergrace.org/forum/how-monitor-radiation-pneumonitis-1289829

  Symptoms of radiation pneumonitis sometimes start during treatment, but they are more likely to occur about 13 months after treatment. Symptoms can include: fever, cough, chest congestion, shortness of breath, and chest discomfort. The cough may be non-productive (dry) or productive (coughing up mucus or phlegm). The amount of mucus with the cough may increase as treatment continues. Symptoms may go away or continue for several weeks or months, becoming a long-term (chronic) problem. […] I don’t think I have a flu or regular pneumonia but who knows? I got all of the symptoms in the book, cough getting more pronounced and feeling quite a terrible malaise. […] Pneumonitis symptoms have diminished nicely. Radiation esophagitis also much better, probably helped by the prednisone.

• #24 Radiation pneumonitis

  https://www.eviq.org.au/clinical-resources/radiation-oncology/side-effect-and-toxicity-management/1895-radiation-pneumonitis

  Radiation pneumonitis is a common toxicity that occurs in patients undergoing radiation therapy for thoracic malignancies and is a known toxicity occurring in patients undergoing radiation therapy for breast malignancies. Radiation pneumonitis can have considerable impact on patient morbidity, including a patients quality of life and respiratory function. However, it usually resolves if treated with corticosteroids. It is rarely fatal. […] Radiation pneumonitis most commonly occurs between 1 and 6 months after treatment. […] Assess patient for: dyspnoea, non-productive cough, low-grade fever, excessive fatigue/malaise, tachycardia, pleuritic chest pain (uncommon), occasionally moist crackles, a pleural friction rub or evidence of consolidation in region corresponding to radiation field (uncommon).

• #25 Pneumonitis: Symptoms, Causes, and Treatments

  https://resources.healthgrades.com/right-care/lungs-breathing-and-respiration/pneumonitis

  If pneumonitis progresses to pulmonary fibrosis, the disease can be severe. The symptoms may worsen over months. […] Seek immediate medical care by calling 911 for any serious symptoms, including chest pain or severe discomfort, cyanosis, a discoloration of the skin, lips, or nails, inability to catch your breath or hungering for air, severe shortness of breath, and a reliable oximeter reading below 90%. […] Pneumonitis can be either acute or chronic. Acute pneumonitis usually lasts a few days to several weeks. However, the disease can become chronic with repeated exposure to the cause. In hypersensitivity pneumonitis, about 5% of people will go on to develop chronic pneumonitis. […] Pneumonitis can resolve on its own if you remove or avoid the offending irritant. However, long-term inflammation can lead to scarring and permanent lung damage called pulmonary fibrosis. This can occur when pneumonitis continues unnoticed or untreated. Pulmonary fibrosis can cause high blood pressure in the lungs, heart failure, and, in extreme cases, respiratory failure that can lead to death. […] Pneumonitis is the inflammation of the lungs, which may result in reduced lung function and difficulty breathing, among other symptoms of respiratory illness.

• #26 Pneumonitis | OncoLink

  https://www.oncolink.org/support/side-effects/pulmonary-side-effects/pneumonitis

  Pneumonitis can cause: Shortness of breath. A low level of oxygen in the body. Fever. Cough. Chest pain with breathing. […] Pneumonitis caused by chemotherapy may start after a few days of getting it. […] Pneumonitis often goes away within a few weeks. […] Call your care team if you are having signs of pneumonitis. Call 911 if you suddenly become short of breath.

• #27 Pneumonitis – Diagnosis and treatment – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/pneumonitis/diagnosis-treatment/drc-20352628

  To diagnose pneumonitis, your doctor or other healthcare professional reviews your medical history and family history. […] If you have pneumonitis caused by chemical irritation or an allergic reaction, your healthcare professional will likely recommend stopping the exposure that’s irritating your lungs. This step should help lessen your symptoms. […] Corticosteroid medicines work by calming your immune system’s reaction to an irritation. This can make your lungs less inflamed. […] Sometimes corticosteroids using an inhaler may help. You breathe these medicines into your lungs. The medicines lessen inflammation in your airway so that it’s easier to breathe. […] Treatment for pneumonitis caused by medicines depends on how severe symptoms are. If symptoms are mild, you may not need any treatment. If your symptoms are severe, treatment with mainly corticosteroids, but sometimes other medicines that lessen your immune system’s reaction, may help.

• #28 Pneumonitis.: Causes, Symptoms, and Treatment | Doctor

  https://patient.info/doctor/pneumonitis

  History of exposure to a precipitating cause – eg, birds, radiotherapy, dusts, drugs, chemicals. […] Clinical features will depend on the severity and underlying cause and may include: Shortness of breath. […] Symptoms which chronic pneumonitis may lead to: fatigue, weight loss, exercise intolerance, cyanosis and finger clubbing. […] Late-diagnosed chronic pneumonitis may lead to progressive, irreversible lung disease.

• #29 Pneumonitis With Immunotherapy Treatment | Oncology Nursing Society

  https://www.ons.org/publications-research/voice/news-views/09-2019/pneumonitis-immunotherapy-treatment

  Pneumonitis is inflammation of the lung parenchyma; although rare, it can be fatal. […] About one-third of patients are asymptomatic and pneumonitis is found incidentally, but the most common presenting symptoms are dyspnea and cough. Other symptoms include wheezing, fatigue, decreased pulse oximetry, and chest pain. Time to onset after initiation of therapy varies (reported at 9 days to 19 months), but the median is 2.8 months. It can occur earlier in combination therapy versus monotherapy. […] Oncology advanced practitioners should be familiar with signs and symptoms of pneumonitis. A high index of suspicion and prompt management of any suspected pulmonary toxicity will lead to better outcomes.

• #30 Interstitial Lung Disease/Pneumonitis | ENHERTU® (fam-trastuzumab deruxtecan-nxki)

  https://www.enhertuhcp.com/en/managing-adverse-reactions/interstitial-lung-disease-pneumonitis

  In patients with mBC, HER2-mutant NSCLC, and other solid tumors treated with ENHERTU 5.4 mg/kg, ILD occurred in 12% of patients. The majority of ILD cases were Grade 1 or 2 (n=228/265). Median time to first onset was 5.5 months (range: 0.9 to 31.5). Fatal outcomes due to ILD and/or pneumonitis occurred in 0.9% of patients treated with ENHERTU. […] In patients with locally advanced or metastatic HER2+ gastric or GEJ adenocarcinoma treated with ENHERTU 6.4 mg/kg, ILD occurred in 10% of patients. Median time to first onset was 2.8 months (range: 1.2 to 21). […] Interstitial lung disease (ILD) and pneumonitis, including fatal cases, have been reported with ENHERTU. Monitor for and promptly investigate signs and symptoms including cough, dyspnea, fever, and other new or worsening respiratory symptoms. Permanently discontinue ENHERTU in all patients with Grade 2 or higher ILD/pneumonitis. Advise patients of the risk and to immediately report symptoms.

• #31 What Is Pneumonitis?

  https://www.webmd.com/lung/what-is-pneumonitis

  You might find it harder to catch your breath when you walk up a flight of stairs, exercise, or do another activity. Other symptoms include: […] Trouble breathing, even when you’re not doing anything […] If you don’t treat pneumonitis, it can start to scar your lungs. This is called pulmonary fibrosis, and it can be very serious.

• #32 Pneumonia | Lung inflammation – Diagnosis, Evaluation and Treatment

  https://www.radiologyinfo.org/en/info/pneumonia

  Patients with pneumonia could have the following symptoms: cough that produces phlegm or sometimes blood, fever, shortness of breath or difficulty breathing, chills or shaking, fatigue, sweating, chest or muscle pain. […] Pneumonia can sometimes lead to serious complications, such as respiratory system failure, spread of infections, fluid surrounding the lungs, abscesses or uncontrolled inflammation throughout the body (sepsis). The condition can also be fatal, so it is important to seek immediate medical attention if you are experiencing these symptoms.

• #33 Pneumonitis – Diagnosis and treatment – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/pneumonitis/diagnosis-treatment/drc-20352628

  If symptoms are mild, you may not need treatment for radiation pneumonitis. Severe symptoms are usually treated with corticosteroids. […] When pneumonitis is severe, treatment also may include: Oxygen therapy. If you’re having a lot of trouble breathing, you may need oxygen therapy through a mask or through a plastic tubing with tips that fit into your nose. […] A diagnosis of pneumonitis may mean that you’ll have to make changes to your lifestyle to protect your health. You’ll need to avoid known triggers as much as possible. […] Don’t smoke. Smoking can make lung damage worse. If you need help quitting, talk to your healthcare professional.

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