Materiały źródłowe

• #1 Learn About Osteosarcoma (Bone Cancer) in Dogs | PetCure Oncology

  https://petcureoncology.com/what-you-should-know-about-osteosarcoma-bone-cancer-in-dogs/

  Osteosarcoma, or bone cancer, is the most common bone cancer seen in dogs. […] Although there is no sure way to prevent this type of cancer from occurring in dogs, regular check-ups with your veterinarian are highly recommended in order to catch any potential signs or symptoms early on. […] Once diagnosed, it is recommended to seek treatment as soon as possible in order to slow down the spread of the disease and reduce pain for your dog. […] Sometimes palliative treatment is recommended. Palliative treatment aims to make your pet more comfortable but doesn’t provide a cure, and can include conventional radiation therapy and drugs to reduce pain. […] Early detection is critical for ensuring successful treatment outcomes.

• #2 Tackling new strategies for canine bone cancer at MCC | Masonic Cancer Center

  https://cancer.umn.edu/news/tackling-new-strategies-canine-bone-cancer-mcc

  Osteosarcoma, the most common form of bone cancer in dogs, is a tumor that usually affects the limbs of middle-aged to older, large breed dogs and carries a dire prognosis. […] Our projects are addressing the impact of this disease by developing strategies for prevention with the intent of reducing overall incidence and by improving our understanding of how we can use the immune system to improve treatment outcomes. […] The interplay between cancer research and care for animals and cancer research and care for humans is critical to uncovering new knowledge and strategies for writing cancer’s last chapter.

• #3 Osteosarcoma Causes, Risk Factors, and Prevention | American Cancer Society

  https://www.cancer.org/cancer/types/osteosarcoma/causes-risks-prevention.html

  The risk of many adult cancers can be reduced with certain lifestyle changes (such as staying at a healthy weight or quitting smoking), but at this time there are no known ways to prevent osteosarcoma. […] Most known risk factors for osteosarcoma cannot be changed. Other than radiation therapy, there are no known lifestyle-related or environmental causes of osteosarcoma, so at this time there is no known way to protect against or prevent most of these cancers.

• #4 Can Osteosarcoma Be Prevented? | American Cancer Society

  https://www.cancer.org/cancer/types/osteosarcoma/causes-risks-prevention/prevention.html

  The risk of many adult cancers can be reduced with certain lifestyle changes (such as staying at a healthy weight or quitting smoking), but at this time there are no known ways to prevent osteosarcoma. […] Other than exposure to radiation (usually during radiation therapy), there are no known lifestyle-related or environmental causes of osteosarcoma, so at this time there is no known way to protect against or prevent most of these cancers.

• #5

  https://www.americanoncology.com/cancer-we-treat/prevention/osteosarcoma

  There are currently no methods to prevent osteosarcoma, as no lifestyle factor is known that increases the risk of osteosarcoma. […] However, quitting smoking, exercising, eating a healthy diet, and improving your lifestyle, can prevent several cancers.

• #6 Bone cancer | Causes, Symptoms & Treatments | Cancer Council

  https://www.cancer.org.au/cancer-information/types-of-cancer/bone-cancer

  There are no proven measures to prevent bone cancer.

• #7 Osteosarcoma in dogs | Joii Pet Care

  https://www.joiipetcare.com/health-conditions/dog/osteosarcoma/

  Osteosarcoma in dogs can be prevented? Sadly there is no known prevention for osteosarcoma.

• #8 Osteosarcoma in Dogs

  https://www.embracepetinsurance.com/health/osteosarcoma

  As with most cancers of genetic and indeterminate origin, there is no accepted approach to the prevention of osteosarcoma.

• #9 Osteosarcoma | Endocrine Society

  https://www.endocrine.org/patient-engagement/endocrine-library/osteosarcoma

  There is nothing that can be done to prevent osteosarcoma. Minimizing exposure to radiation might be a strategy to decrease the chances of osteosarcoma appearing. […] Some risk factors include rapid bone growth with an increased risk during a child’s growth spurts. Genetic factors linked to osteosarcoma by a mutation of the retinoblastoma gene or TP53 gene. In adults, Paget’s disease (increased activity of the osteoclasts, the cells that chew bone during normal bone remodeling) and exposure to radiation increase the chances of osteosarcoma.

• #10 Best Osteosarcoma Cancer Treatment in Delhi, India | Symptoms, Causes, and Treatment Therapy

  https://www.maxhealthcare.in/our-specialities/cancer-care-oncology/conditions-treatments/osteosarcoma

  Osteosarcoma prevention primarily focuses on reducing known risk factors and promoting healthy lifestyle habits. While osteosarcoma is not entirely preventable, some measures may help lower the risk: […] Avoid Radiation Exposure: Minimise exposure to ionising radiation, as it is a known risk factor for osteosarcoma development. This includes limiting unnecessary medical imaging procedures involving radiation. […] Limit Chemical Exposure: Limit exposure to chemicals known to increase the risk of osteosarcoma, such as certain herbicides and pesticides. Protective measures should be taken when handling potentially carcinogenic substances. […] Healthy Lifestyle Choices: Encourage maintaining a healthy lifestyle, including a balanced diet rich in fruits and vegetables, regular physical activity, and avoidance of tobacco and excessive alcohol consumption.

• #11 Best Osteosarcoma Cancer Treatment in Delhi, India | Symptoms, Causes, and Treatment Therapy

  https://www.maxhealthcare.in/our-specialities/cancer-care-oncology/conditions-treatments/osteosarcoma

  Osteosarcoma prevention primarily focuses on reducing known risk factors and promoting healthy lifestyle habits. While osteosarcoma is not entirely preventable, some measures may help lower the risk: […] Avoid Radiation Exposure: Minimise exposure to ionising radiation, as it is a known risk factor for osteosarcoma development. This includes limiting unnecessary medical imaging procedures involving radiation. […] Limit Chemical Exposure: Limit exposure to chemicals known to increase the risk of osteosarcoma, such as certain herbicides and pesticides. Protective measures should be taken when handling potentially carcinogenic substances. […] Healthy Lifestyle Choices: Encourage maintaining a healthy lifestyle, including a balanced diet rich in fruits and vegetables, regular physical activity, and avoidance of tobacco and excessive alcohol consumption.

• #12 How to Prevent Bone Cancer? | Tips to Reduce Risk

  https://amerixcancer.com/how-to-prevent-bone-cancer/

  Bone cancer is easier to treat when it is diagnosed at an early stage. By understanding the risk factors and preventative measures for bone cancer, you can reduce the chance of getting bone cancer. […] Preventing bone cancer can be a daunting task if you have some inherited genetic mutations or other disease conditions. Other risk factors, which are mostly lifestyle-related, can be changed. Reducing the risk factors can directly reduce your risk of getting bone cancer. […] The following measures have been found useful in several studies which focused on reducing the risk of bone cancer: […] The best way to prevent advanced-stage cancer is a routine check-up. […] Radiation is a significant risk factor for bone cancer. Completely avoid unnecessary radiation exposure. […] A high-fibre and low-fat diet with all essential nutrients and proteins should be followed. […] Physical inactivity is a significant risk of bone cancer. […] Smoking or chewing tobacco reduces bone density and weakens them. […] If you have been diagnosed with Pagets disease or osteoporosis, pay extra attention to your bone health.

• #13 Osteosarcoma following single fraction radiation prophylaxis for heterotopic ossification | Radiation Oncology | Full Text

  https://ro-journal.biomedcentral.com/articles/10.1186/1748-717X-7-140

  Radiotherapy for prophylaxis of heterotopic ossification (HO) is commonly used in high risk patients following orthopedic surgery. […] While a rare complication, we stress the importance of informing regarding the risk of a radiation induced malignancy following HO prophylaxis. […] The idea that RT could be used to prevent HO is based largely on the assumption that osteoprogenitor cells present in soft tissues in the beginning phases of HO, would be highly mitotic and therefore sensitive to RT. […] Coventrey et al. concluded that RT was an effective means of HO prevention. […] The potential downsides to RT however, include effects on fertility, and the possibility of radiation induced malignancy. […] To maintain efficacy, treatment is generally given within 4 days of surgical intervention based on studies by Sylvester et al.

• #14 Osteosarcoma following single fraction radiation prophylaxis for heterotopic ossification | Radiation Oncology | Full Text

  https://ro-journal.biomedcentral.com/articles/10.1186/1748-717X-7-140

  The effectiveness of a single fraction to 7Gy has been determined equivalent to higher doses or multiple fractions. […] A single fraction of 7Gy has therefore become common practice. […] Although RIS remains a rare treatment complication, there are several other disadvantages of RT in this setting including considerable costs, and scheduling difficulties given the narrow 34 day treatment window. […] Non-steroidal anti-inflammatory drugs (NSAIDs) can serve as an alternative method of HO prophylaxis presumably through systemic inhibition of prostaglandins that promote osteoprogenitor development. […] Compared to RT, NSAIDs are a considerably less expensive option, but patients often have poor compliance due to gastritis or other GI complications. […] Radiotherapy remains an effective method of prophylaxis for HO in high risk patients. […] It is important to inform patients regarding the risk of a radiation induced malignancy. […] Based on the reported case, we suggest that prior to recommending prophylactic RT for young patients at risk for HO, the potential risks should be weighed strongly against the benefits.

• #15 Osteosarcoma following single fraction radiation prophylaxis for heterotopic ossification | Radiation Oncology | Full Text

  https://ro-journal.biomedcentral.com/articles/10.1186/1748-717X-7-140

  The effectiveness of a single fraction to 7Gy has been determined equivalent to higher doses or multiple fractions. […] A single fraction of 7Gy has therefore become common practice. […] Although RIS remains a rare treatment complication, there are several other disadvantages of RT in this setting including considerable costs, and scheduling difficulties given the narrow 34 day treatment window. […] Non-steroidal anti-inflammatory drugs (NSAIDs) can serve as an alternative method of HO prophylaxis presumably through systemic inhibition of prostaglandins that promote osteoprogenitor development. […] Compared to RT, NSAIDs are a considerably less expensive option, but patients often have poor compliance due to gastritis or other GI complications. […] Radiotherapy remains an effective method of prophylaxis for HO in high risk patients. […] It is important to inform patients regarding the risk of a radiation induced malignancy. […] Based on the reported case, we suggest that prior to recommending prophylactic RT for young patients at risk for HO, the potential risks should be weighed strongly against the benefits.

• #16 How to Prevent Bone Cancer & Risk Factor | HCG Oncology

  http://www.hcgoncology.com/types-of-cancers/bone-cancer-prevention/

  Unfortunately, there is no confirmed answer to the question 'how to prevent bone cancer.’ However, early detection and an understanding of the bone cancer risk factors can surely increase the chances of a successful treatment. […] Though there is no definite way to prevent bone cancer, there are some things that can help in the process. […] Avoid smoking […] Healthy diet […] Limit alcohol […] Exercise […] Get checked regularly […] Understanding bone cancer prevention and risk factors is highly helpful for doctors in selecting a relevant line of treatment as per an individual patient’s needs and requirements. Also, individuals can take proactive steps to reduce their chances of developing cancer. […] Yes, early detection and timely treatment of bone diseases may help reduce the risk of bone cancer.

• #17 Osteosarcoma Risk Factors and Prevention Measures | HCG

  https://www.hcgoncology.com/types-of-cancers/osteosarcoma-prevention/

  Osteosarcoma prevention primarily involves understanding and addressing risk factors. While it may not be entirely preventable, avoiding therapeutic radiation when possible, managing pre-existing bone conditions, and staying vigilant for hereditary factors can contribute to osteosarcoma prevention. Regular medical check-ups and awareness of potential symptoms enhance early detection and intervention. […] While specific osteosarcoma prevention methods may be limited, proactive measures such as understanding risk factors and seeking timely medical attention can significantly impact outcomes. A comprehensive approach involving risk reduction and early detection is crucial for managing osteosarcoma.

• #18 Bone Cancer: Symptoms, Treatment & Outlook

  https://my.clevelandclinic.org/health/diseases/17745-bone-cancer

  As experts dont really know what causes bone cancers, theres currently no known way to prevent it. […] Still, you can see a healthcare provider if youre noticing unusual changes in your bones, like a lump or increasing bone pain. These symptoms dont usually mean cancer. But only a provider can diagnose whats causing the issue.

• #19 Best Osteosarcoma Cancer Treatment in Delhi, India | Symptoms, Causes, and Treatment Therapy

  https://www.maxhealthcare.in/our-specialities/cancer-care-oncology/conditions-treatments/osteosarcoma

  Genetic Counselling: Individuals with certain genetic conditions, such as Li-Fraumeni syndrome or hereditary retinoblastoma, have an increased risk of developing osteosarcoma. Genetic counselling and testing may be recommended for individuals with a family history of these conditions. […] While these preventive measures can reduce the risk of osteosarcoma, it’s essential to remember that not all cases can be prevented. Regular medical check-ups and prompt evaluation of any concerning symptoms are crucial for early detection and treatment if osteosarcoma does occur.

• #20 Bone Cancer Symptoms and How to Prevent It – EMC Healthcare – SAME

  https://www.emc.id/en/care-plus/bone-cancer-full-review-of-symptoms-and-early-prevention

  Unfortunately, there are no concrete steps that can be taken to prevent bone cancer because this disease is related to certain bone abnormalities, age, and genetic or hereditary factors. […] Nevertheless, having regular health check-ups can help in early detection of this disease, allowing prompt treatment. The sooner bone cancer is detected, the greater the chance of cure. Regular check-ups are also important for people at high risk of bone cancer or other types of cancer. […] Although there are no definitive preventive measures, a healthy lifestyle can help lower the risk: Stay active by exercising regularly and avoiding smoking and excessive alcohol consumption. Adopt a healthy diet by increasing consumption of fruit, vegetables, whole grains, fish and low-fat dairy products, and avoiding processed foods high in saturated fat. Maintain an ideal body weight through a combination of a healthy diet and physical activity, because obesity can increase the risk of cancer. If exposed to radiation in work or daily activities, be sure to use appropriate protection. Be aware of personal risk factors such as a family history of cancer or certain genetic conditions, and take appropriate preventative steps. Ensure adequate vitamin D intake for bone health. Avoid contact with dangerous chemicals or heavy metals that can increase the risk of bone cancer. Avoid activities that have a risk of causing bone injury. If injury occurs, seek appropriate medical treatment immediately.

• #21 How to Prevent Bone Cancer? | Tips to Reduce Risk

  https://amerixcancer.com/how-to-prevent-bone-cancer/

  Bone cancer is easier to treat when it is diagnosed at an early stage. By understanding the risk factors and preventative measures for bone cancer, you can reduce the chance of getting bone cancer. […] Preventing bone cancer can be a daunting task if you have some inherited genetic mutations or other disease conditions. Other risk factors, which are mostly lifestyle-related, can be changed. Reducing the risk factors can directly reduce your risk of getting bone cancer. […] The following measures have been found useful in several studies which focused on reducing the risk of bone cancer: […] The best way to prevent advanced-stage cancer is a routine check-up. […] Radiation is a significant risk factor for bone cancer. Completely avoid unnecessary radiation exposure. […] A high-fibre and low-fat diet with all essential nutrients and proteins should be followed. […] Physical inactivity is a significant risk of bone cancer. […] Smoking or chewing tobacco reduces bone density and weakens them. […] If you have been diagnosed with Pagets disease or osteoporosis, pay extra attention to your bone health.

• #22 Osteosarcoma – What You Need to Know

  https://www.drugs.com/cg/osteosarcoma.html

  Do not smoke. Smoking increases your risk for new or returning cancer. Smoking can also delay healing after treatment. Ask your healthcare provider for information if you currently smoke and need help quitting. […] Limit or do not drink alcohol as directed. Limit alcohol to 2 drinks per day if you are a man. Limit alcohol to 1 drink per day if you are a woman. A drink of alcohol is 12 ounces of beer, 5 ounces of wine, or 1½ ounces of liquor. […] Eat a variety of healthy foods. Healthy foods include fruits, vegetables, whole-grain breads, low-fat dairy products, beans, lean meats, and fish. Ask if you need to be on a special diet. […] Drink liquids as directed. You may need to drink more liquid during cancer treatment. Ask your healthcare provider how much liquid to drink each day and which liquids are best for you.

• #23 Bone Cancer Symptoms and How to Prevent It – EMC Healthcare – SAME

  https://www.emc.id/en/care-plus/bone-cancer-full-review-of-symptoms-and-early-prevention

  Unfortunately, there are no concrete steps that can be taken to prevent bone cancer because this disease is related to certain bone abnormalities, age, and genetic or hereditary factors. […] Nevertheless, having regular health check-ups can help in early detection of this disease, allowing prompt treatment. The sooner bone cancer is detected, the greater the chance of cure. Regular check-ups are also important for people at high risk of bone cancer or other types of cancer. […] Although there are no definitive preventive measures, a healthy lifestyle can help lower the risk: Stay active by exercising regularly and avoiding smoking and excessive alcohol consumption. Adopt a healthy diet by increasing consumption of fruit, vegetables, whole grains, fish and low-fat dairy products, and avoiding processed foods high in saturated fat. Maintain an ideal body weight through a combination of a healthy diet and physical activity, because obesity can increase the risk of cancer. If exposed to radiation in work or daily activities, be sure to use appropriate protection. Be aware of personal risk factors such as a family history of cancer or certain genetic conditions, and take appropriate preventative steps. Ensure adequate vitamin D intake for bone health. Avoid contact with dangerous chemicals or heavy metals that can increase the risk of bone cancer. Avoid activities that have a risk of causing bone injury. If injury occurs, seek appropriate medical treatment immediately.

• #24 Osteosarcoma – What You Need to Know

  https://www.drugs.com/cg/osteosarcoma.html

  Do not smoke. Smoking increases your risk for new or returning cancer. Smoking can also delay healing after treatment. Ask your healthcare provider for information if you currently smoke and need help quitting. […] Limit or do not drink alcohol as directed. Limit alcohol to 2 drinks per day if you are a man. Limit alcohol to 1 drink per day if you are a woman. A drink of alcohol is 12 ounces of beer, 5 ounces of wine, or 1½ ounces of liquor. […] Eat a variety of healthy foods. Healthy foods include fruits, vegetables, whole-grain breads, low-fat dairy products, beans, lean meats, and fish. Ask if you need to be on a special diet. […] Drink liquids as directed. You may need to drink more liquid during cancer treatment. Ask your healthcare provider how much liquid to drink each day and which liquids are best for you.

• #25 Osteosarcoma – What You Need to Know

  https://www.drugs.com/cg/osteosarcoma.html

  Do not smoke. Smoking increases your risk for new or returning cancer. Smoking can also delay healing after treatment. Ask your healthcare provider for information if you currently smoke and need help quitting. […] Limit or do not drink alcohol as directed. Limit alcohol to 2 drinks per day if you are a man. Limit alcohol to 1 drink per day if you are a woman. A drink of alcohol is 12 ounces of beer, 5 ounces of wine, or 1½ ounces of liquor. […] Eat a variety of healthy foods. Healthy foods include fruits, vegetables, whole-grain breads, low-fat dairy products, beans, lean meats, and fish. Ask if you need to be on a special diet. […] Drink liquids as directed. You may need to drink more liquid during cancer treatment. Ask your healthcare provider how much liquid to drink each day and which liquids are best for you.

• #26 Bone Cancer Symptoms and How to Prevent It – EMC Healthcare – SAME

  https://www.emc.id/en/care-plus/bone-cancer-full-review-of-symptoms-and-early-prevention

  Unfortunately, there are no concrete steps that can be taken to prevent bone cancer because this disease is related to certain bone abnormalities, age, and genetic or hereditary factors. […] Nevertheless, having regular health check-ups can help in early detection of this disease, allowing prompt treatment. The sooner bone cancer is detected, the greater the chance of cure. Regular check-ups are also important for people at high risk of bone cancer or other types of cancer. […] Although there are no definitive preventive measures, a healthy lifestyle can help lower the risk: Stay active by exercising regularly and avoiding smoking and excessive alcohol consumption. Adopt a healthy diet by increasing consumption of fruit, vegetables, whole grains, fish and low-fat dairy products, and avoiding processed foods high in saturated fat. Maintain an ideal body weight through a combination of a healthy diet and physical activity, because obesity can increase the risk of cancer. If exposed to radiation in work or daily activities, be sure to use appropriate protection. Be aware of personal risk factors such as a family history of cancer or certain genetic conditions, and take appropriate preventative steps. Ensure adequate vitamin D intake for bone health. Avoid contact with dangerous chemicals or heavy metals that can increase the risk of bone cancer. Avoid activities that have a risk of causing bone injury. If injury occurs, seek appropriate medical treatment immediately.

• #27 Bone Cancer Symptoms and How to Prevent It – EMC Healthcare – SAME

  https://www.emc.id/en/care-plus/bone-cancer-full-review-of-symptoms-and-early-prevention

  Unfortunately, there are no concrete steps that can be taken to prevent bone cancer because this disease is related to certain bone abnormalities, age, and genetic or hereditary factors. […] Nevertheless, having regular health check-ups can help in early detection of this disease, allowing prompt treatment. The sooner bone cancer is detected, the greater the chance of cure. Regular check-ups are also important for people at high risk of bone cancer or other types of cancer. […] Although there are no definitive preventive measures, a healthy lifestyle can help lower the risk: Stay active by exercising regularly and avoiding smoking and excessive alcohol consumption. Adopt a healthy diet by increasing consumption of fruit, vegetables, whole grains, fish and low-fat dairy products, and avoiding processed foods high in saturated fat. Maintain an ideal body weight through a combination of a healthy diet and physical activity, because obesity can increase the risk of cancer. If exposed to radiation in work or daily activities, be sure to use appropriate protection. Be aware of personal risk factors such as a family history of cancer or certain genetic conditions, and take appropriate preventative steps. Ensure adequate vitamin D intake for bone health. Avoid contact with dangerous chemicals or heavy metals that can increase the risk of bone cancer. Avoid activities that have a risk of causing bone injury. If injury occurs, seek appropriate medical treatment immediately.

• #28 OS Therapies Announces Phase 2b Clinical Trial of OST-HER2 Achieves Primary Endpoint with Statistical Significance in the Prevention of Recurrent, Fully Resected, Lung Metastatic Osteosarcoma

  https://www.businesswire.com/news/home/20250115320117/en/OS-Therapies-Announces-Phase-2b-Clinical-Trial-of-OST-HER2-Achieves-Primary-Endpoint-with-Statistical-Significance-in-the-Prevention-of-Recurrent-Fully-Resected-Lung-Metastatic-Osteosarcoma

  OS Therapies Announces Phase 2b Clinical Trial of OST-HER2 Achieves Primary Endpoint with Statistical Significance in the Prevention of Recurrent, Fully Resected, Lung Metastatic Osteosarcoma […] The data demonstrate statistically significant results in the primary endpoint of the study, 12-month event free survival (‘EFS’), where an event is defined as the recurrence of metastatic osteosarcoma, in OST-HER2-treated patients when compared with the leading published historical comparable control group. […] The strong safety profile shown in this study also supports the use of OST-HER2 in this incredibly difficult-to-treat population that has no currently approved therapies. […] The achievement of the primary endpoint in the OST-HER2 phase 2b is a tremendous success that opens the possibility, for the first time, of meaningful therapy for patients suffering from osteosarcoma with lung metastases after resection.

• #29 OS Therapies Announces Phase 2b Clinical Trial of OST-HER2 Achieves Primary Endpoint with Statistical Significance in the Prevention of Recurrent, Fully Resected, Lung Metastatic Osteosarcoma

  https://www.businesswire.com/news/home/20250115320117/en/OS-Therapies-Announces-Phase-2b-Clinical-Trial-of-OST-HER2-Achieves-Primary-Endpoint-with-Statistical-Significance-in-the-Prevention-of-Recurrent-Fully-Resected-Lung-Metastatic-Osteosarcoma

  OST-HER2 is an innovative immunotherapy using a HER2 bioengineered form of the bacteria Listeria monocytogenes (Lm) to trigger a strong immune response against cancer cells expressing HER2. This off-the-shelf immunotherapy treatment is designed to prevent metastasis, delay recurrence, kill primary tumors expressing HER2 alone and potentially in combination with existing approved therapies, and increase overall survival. […] The US FDA granted OST-HER2 rare pediatric disease designation for osteosarcoma in 2021. […] The Company believes the market opportunity for OST-HER2 in the prevention of lung metastases is over $500 million. […] OS Therapies remains eligible to receive the PRV upon approval of OST-HER2 in recurrent, resected metastatic osteosarcoma. […] OS Therapies (NYSE-A: OSTX) (the “Company”), a clinical-stage immunotherapy and Antibody Drug Conjugate (ADC) biopharmaceutical company, today announced that the US Food & Drug Administration (“FDA”) granted the Company’s meeting request to gain alignment on the surrogate endpoint to support Breakthrough Therapy Designation & Accelerated Approval of OST-HER2 in the Prevention of Recurrence of Fully Resected, Lung Metastatic Osteosarcoma.

• #30 Pharmacological prevention of surgery-accelerated metastasis in an animal model of osteosarcoma – PubMed

  https://pubmed.ncbi.nlm.nih.gov/32354335/

  Surgery-accelerated metastasis is mediated in part through tumor supportive alterations in macrophage phenotype. […] Targeted pharmacologic therapies that prevent pro-tumor changes in macrophage phenotype could be utilized perioperatively to mitigate surgery-accelerated metastasis and improve the therapeutic benefits of surgery.

• #31 Pharmacological prevention of surgery-accelerated metastasis in an animal model of osteosarcoma | Journal of Translational Medicine | Full Text

  https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-020-02348-2

  Surgery-accelerated metastasis is mediated in part through tumor supportive alterations in macrophage phenotype. […] Targeted pharmacologic therapies that prevent pro-tumor changes in macrophage phenotype could be utilized perioperatively to mitigate surgery-accelerated metastasis and improve the therapeutic benefits of surgery. […] Treatment with gefitinib prevented tumor-supportive alterations in macrophage phenotype and resulted in reduced metastasis. […] Peri-operative treatment with gefitinib resulted in reversal of the pro-tumor macrophage phenotype to a more anti-tumor state, which was associated with a significant reduction in metastases after surgery. […] Thus, gefitinib clearly has therapeutic value as a pharmacological adjunct to surgery in this model of osteosarcoma.

• #32 Pharmacological prevention of surgery-accelerated metastasis in an animal model of osteosarcoma

  https://pmc.ncbi.nlm.nih.gov/articles/PMC7193344/

  Surgery-accelerated metastasis is mediated in part through tumor supportive alterations in macrophage phenotype. […] Targeted pharmacologic therapies that prevent pro-tumor changes in macrophage phenotype could be utilized perioperatively to mitigate surgery-accelerated metastasis and improve the therapeutic benefits of surgery. […] Peri-operative treatment with gefitinib resulted in reversal of the pro-tumor macrophage phenotype to a more anti-tumor state, which was associated with a significant reduction in metastases after surgery. […] This study provides novel insights into the mechanisms of surgery-accelerated metastasis in OS. […] Understanding these mechanisms will allow for the development of novel treatment approaches that will serve to further enhance the benefits of surgery. […] This study identifies gefitinib, an already FDA-approved medication, as a potential surgical adjunct to mitigate the unwanted consequences of surgery, thereby enhancing its benefits.

• #33 Prevention of multidrug resistance (MDR) in osteosarcoma by NSC23925 | British Journal of Cancer

  https://www.nature.com/articles/bjc2014254

  The major limitation to the success of chemotherapy in osteosarcoma is the development of multidrug resistance (MDR). […] Preventing the emergence of MDR during chemotherapy treatment has been a high priority of clinical and investigational oncology, but it remains an elusive goal. […] Therefore, this study aims to evaluate the effects of NSC23925 on prevention of the development of MDR in osteosarcoma. […] Our findings suggest that NSC23925 may prevent the development of MDR by specifically preventing the overexpression of Pgp. […] Given the significant incidence of MDR in osteosarcoma and the lack of effective agents for prevention of MDR, NSC23925 and derivatives hold the potential to improve the outcome of cancer patients with poor prognosis due to drug resistance. […] However, preventing the development of MDR during the course of chemotherapy and exploring the underlying molecular machinery rather than reversing MDR once it has arisen may fundamentally aid in the design of strategies for overcoming MDR in cancer.

• #34 Prevention of multidrug resistance (MDR) in osteosarcoma by NSC23925 | British Journal of Cancer

  https://www.nature.com/articles/bjc2014254

  A number of drugs, such as verapamil, cyclosporin A (CsA), VX710, XR9576, P85 (Pluronic 85) and LGD1069 (bexarotene) have been tested as the preventers that avert the development of MDR. […] Therefore, development of more potent and selective MDR preventers is needed. […] The NSC23925 is a small molecular compound that was identified as an effective and selective inhibitor of Pgp in previous studies. […] Importantly, the combination of paclitaxel and NSC23925 produced a significant inhibitory effect on the growth of xenograft ovarian cancer MDR tumour models as compared with animals treated with paclitaxel alone. […] Therefore, in this study, we evaluated the effects of NSC23925 on the prevention of the development of MDR in the osteosarcoma cell lines U-2OS and Saos. […] NSC23925 has the ability to prevent the development of MDR in human osteosarcoma U-2OS and Saos cells.

• #35 Prevention of multidrug resistance (MDR) in osteosarcoma by NSC23925 | British Journal of Cancer

  https://www.nature.com/articles/bjc2014254

  Our findings indicate that NSC23925 can prevent the emergence of MDR in osteosarcoma by specifically preventing the expression of Pgp during chemotherapeutic drug treatment. […] NSC23925 prevents the increased expression of Pgp and therefore prevents increased efflux and/or decreased influx of drugs during chemotherapy treatment. […] These findings provide an indication of the mechanism by which NSC23925 prevents the emergence of MDR in osteosarcoma. […] The inclusion of drugs or agents that can prevent the development of MDR may enable patients who initially responded to therapy to continue responding without the development of MDR, and therefore provide significant clinical benefits. […] Preventing the overexpression of Pgp has been identified as an efficient approach to inhibit the development of MDR during chemotherapeutic drug treatment. […] In summary, our findings indicate that NSC23925 can prevent the development of MDR in osteosarcoma by specifically preventing the overexpression of Pgp during chemotherapeutic drug treatment.

• #36 Europium-doped hybrid nano-complexes: a potential strategy for metastasis prevention in osteosarcoma – Materials Advances (RSC Publishing)

  https://pubs.rsc.org/en/content/articlelanding/2024/ma/d3ma00939d

  Metastasis is a major issue in cancer therapy, resulting in poor prognosis and death. However, there is currently no widely established prophylactic strategy for early metastasis in the clinical setting. […] Taken together, our results provide evidences that the Eu:SPIO@BSA nano-complex, with precise delivery, higher hemocompatibility and low liver toxicity, is a potential candidate for improving the therapeutic efficacy of metastasis prevention in osteosarcoma.

• #37 Pediatric Osteosarcoma Medication: Antineoplastic agents, Antiemetic agents, Colony-stimulating factors, Antidotes

  https://emedicine.medscape.com/article/988516-medication

  Trimethoprim-sulfamethoxazole: At some treatment centers, clinicians routinely prescribe prophylaxis against pneumocystic pneumonia; others do not. […] Clotrimazole: Prophylactic therapy for thrush may be discontinued when chemotherapy has been completed. […] Chlorhexidine mouth rinse: Prophylaxis against gingivitis and other mouth infections may be discontinued when chemotherapy is completed.

• #38 Tackling new strategies for canine bone cancer at MCC | Masonic Cancer Center

  https://cancer.umn.edu/news/tackling-new-strategies-canine-bone-cancer-mcc

  Osteosarcoma, the most common form of bone cancer in dogs, is a tumor that usually affects the limbs of middle-aged to older, large breed dogs and carries a dire prognosis. […] Our projects are addressing the impact of this disease by developing strategies for prevention with the intent of reducing overall incidence and by improving our understanding of how we can use the immune system to improve treatment outcomes. […] The interplay between cancer research and care for animals and cancer research and care for humans is critical to uncovering new knowledge and strategies for writing cancer’s last chapter.

• #39 AKC Canine Health Foundation | New Researchers Tackle New Strategies for Canine Bone Cancer

  https://www.akcchf.org/educational-resources/library/articles/new-researchers-tackle-new.html

  We need new strategies to treat and even prevent bone cancer in dogs! […] One CHF-funded study is examining why dogs and children with immune cells inside their bone tumors survive longer than those whose immune cells remain outside of the tumors. […] Understanding the immune landscape that leads to improved clinical responses is a deliberate step toward a brighter future for dogs facing this devastating disease. […] Our projects are addressing the impact of this disease by developing strategies for prevention, with the intent of reducing its overall incidence, and by improving our understanding for how we can use the immune system to improve treatment outcomes.

• #40 AKC Canine Health Foundation | Canine Osteosarcoma Early Detection: Preliminary Results from the COED Study

  https://www.akcchf.org/educational-resources/Webinars/canine-osteosarcoma-early.html

  Primary bone cancers (called osteosarcomas) affect more than 8,000 dogs, and possibly as many as 50,000 dogs per year in the United States. […] Thus, better strategies to manage this cancer are needed. To meet this need, investigators are developing tests that allow the detection of osteosarcoma at or near its origin. Early detection, in turn, will enable the deployment of strategic prevention in dogs at high risk. […] investigators will review their progress in developing a blood test for early detection of osteosarcoma as the initial step in their long-term strategy of early detection and targeted prevention for this deadly cancer.

• #41 Osteosarcoma in Dogs – DogCancer.com

  https://www.dogcancer.com/articles/types-of-dog-cancer/osteosarcoma-in-dogs/

  There is no absolute way to prevent osteosarcoma, although there may be ways to lower the risk. In high-risk breeds, consider delaying spay or neuter surgery until at least one year of age and allow females to go through at least one heat cycle. Early evidence suggests this may reduce risk, although it is not a guaranteed prevention strategy.

• #42 Can Osteosarcoma Be Prevented? | American Cancer Society

  https://www.cancer.org/cancer/types/osteosarcoma/causes-risks-prevention/prevention.html

  The risk of many adult cancers can be reduced with certain lifestyle changes (such as staying at a healthy weight or quitting smoking), but at this time there are no known ways to prevent osteosarcoma. […] Other than exposure to radiation (usually during radiation therapy), there are no known lifestyle-related or environmental causes of osteosarcoma, so at this time there is no known way to protect against or prevent most of these cancers.

• #43 Osteosarcoma Risk Factors and Prevention Measures | HCG

  https://www.hcgoncology.com/types-of-cancers/osteosarcoma-prevention/

  Osteosarcoma prevention primarily involves understanding and addressing risk factors. While it may not be entirely preventable, avoiding therapeutic radiation when possible, managing pre-existing bone conditions, and staying vigilant for hereditary factors can contribute to osteosarcoma prevention. Regular medical check-ups and awareness of potential symptoms enhance early detection and intervention. […] While specific osteosarcoma prevention methods may be limited, proactive measures such as understanding risk factors and seeking timely medical attention can significantly impact outcomes. A comprehensive approach involving risk reduction and early detection is crucial for managing osteosarcoma.

• #44 Tackling new strategies for canine bone cancer at MCC | Masonic Cancer Center

  https://cancer.umn.edu/news/tackling-new-strategies-canine-bone-cancer-mcc

  Osteosarcoma, the most common form of bone cancer in dogs, is a tumor that usually affects the limbs of middle-aged to older, large breed dogs and carries a dire prognosis. […] Our projects are addressing the impact of this disease by developing strategies for prevention with the intent of reducing overall incidence and by improving our understanding of how we can use the immune system to improve treatment outcomes. […] The interplay between cancer research and care for animals and cancer research and care for humans is critical to uncovering new knowledge and strategies for writing cancer’s last chapter.

Zobacz więcej