Afazja
Etiologia i przyczyny

Afazja jest nabytym zaburzeniem językowym wynikającym z uszkodzenia obszarów mózgu odpowiedzialnych za produkcję i rozumienie języka, najczęściej w lewej półkuli dominującej. Najczęstszą przyczyną jest udar mózgu, występujący u 25-40% pacjentów po incydencie, zwłaszcza w obszarze unaczynionym przez lewą tętnicę środkową mózgu. Inne istotne etiologie to urazy czaszkowo-mózgowe, guzy mózgu, infekcje OUN oraz choroby neurodegeneracyjne, w tym pierwotna afazja postępująca (PPA). Lokalizacja uszkodzenia determinuje typ afazji: uszkodzenie okolicy Broki powoduje afazję ekspresyjną, Wernickego – receptywną, a rozległe uszkodzenia obu tych obszarów – afazję globalną. W PPA obserwuje się stopniową atrofiię płatów czołowych, skroniowych lub ciemieniowych po lewej stronie, z podtypami związanymi z różnymi patologiami białkowymi (tau, TDP-43, beta-amyloid). Afazja poudarowa wykazuje tendencję do poprawy w ciągu 3-6 miesięcy, natomiast afazja neurodegeneracyjna ma charakter postępujący.

Etiologia afazji

Afazja to zaburzenie językowe spowodowane uszkodzeniem określonych obszarów mózgu odpowiedzialnych za produkcję i rozumienie języka. Może wpływać na zdolność mówienia, pisania, czytania i rozumienia języka mówionego. W przeciwieństwie do innych zaburzeń rozwojowych, afazja jest zawsze nabyta i nie występuje od urodzenia. Najczęściej dotyka obszarów półkuli dominującej, zazwyczaj lewej, która kontroluje funkcje językowe.123

Udar mózgu jako główna przyczyna afazji

Udar mózgu stanowi najczęstszą przyczynę afazji, występując u około 25-40% osób, które przeżyły udar.123 Afazja może wystąpić nagle jako skutek udaru niedokrwiennego lub krwotocznego. W przypadku udaru niedokrwiennego dochodzi do zablokowania naczynia krwionośnego, co powoduje ograniczenie dopływu krwi do mózgu, a w konsekwencji brak tlenu i składników odżywczych niezbędnych do podtrzymania funkcji komórek nerwowych w obszarach odpowiedzialnych za język.12

Uszkodzenie najczęściej dotyczy obszarów unaczynionych przez lewą tętnicę środkową mózgu. Przy rozległym uszkodzeniu tych rejonów może rozwinąć się afazja globalna, będąca najcięższą formą tego zaburzenia.12 W przypadku udaru krwotocznego, pęknięcie naczynia powoduje wylew krwi, która działa toksycznie na tkankę mózgową, prowadząc do obumierania neuronów.12

Urazy mózgu i ich wpływ na rozwój afazji

Urazy czaszkowo-mózgowe (TBI) są drugą najczęstszą przyczyną afazji.12 Mogą one powstać w wyniku wypadków komunikacyjnych, upadków, obrażeń sportowych czy ran postrzałowych.1 Uszkodzenie tkanki mózgowej w obszarach odpowiedzialnych za język, zwłaszcza w lewej półkuli, może prowadzić do zaburzeń językowych o różnym stopniu nasilenia.1

W przypadku urazów mózgu afazja rzadko występuje jako izolowane zaburzenie – najczęściej towarzyszą jej inne deficyty poznawcze, takie jak problemy z pamięcią czy zaburzenia świadomości.1 Nasilenie objawów afazji po urazie zależy od lokalizacji i rozległości uszkodzenia mózgu.12

Guzy mózgu jako przyczyna afazji

Guzy mózgu, zarówno pierwotne jak i przerzutowe, mogą prowadzić do rozwoju afazji, gdy rosną w obszarach kontrolujących funkcje językowe lub uciskają te rejony.12 W przeciwieństwie do nagłego początku afazji po udarze czy urazie, w przypadku guzów mózgu zaburzenia językowe często rozwijają się stopniowo, w miarę powiększania się guza.12

W przypadku wolno rosnących guzów mózg może wykazywać zdolność do adaptacji poprzez przeniesienie funkcji językowych do innych obszarów, co może częściowo łagodzić objawy afazji.1 Rokowanie w afazji spowodowanej guzem mózgu zależy od skuteczności leczenia onkologicznego, jednak nawet po usunięciu guza niektóre osoby mogą doświadczać długotrwałych problemów z komunikacją.1

Infekcje mózgu prowadzące do afazji

Infekcje ośrodkowego układu nerwowego, takie jak zapalenie opon mózgowo-rdzeniowych czy zapalenie mózgu, mogą również prowadzić do afazji.12 Przykładem jest zapalenie mózgu wywołane wirusem opryszczki, które może powodować uszkodzenie płatów skroniowych i czołowych, prowadząc do zaburzeń językowych.1

Afazja spowodowana infekcją mózgu często ma charakter przejściowy i ustępuje wraz z leczeniem zakażenia. Jednak w przypadku ciężkich infekcji powodujących trwałe uszkodzenie obszarów językowych mózgu, afazja może utrzymywać się długoterminowo.1 Na rozwój infekcji mózgu szczególnie narażone są osoby z obniżoną odpornością.1

Choroby neurodegeneracyjne a afazja

Choroby neurodegeneracyjne stanowią istotną przyczynę afazji, szczególnie afazji postępującej.1 Do najczęstszych schorzeń neurodegeneracyjnych powodujących afazję należą:

  • Pierwotna afazja postępująca (PPA) – stan, w którym zdolności językowe ulegają stopniowemu pogorszeniu, prowadząc do utraty umożność czytania, pisania, mówienia i rozumienia mowy12
  • Zwyrodnienie płatów czołowo-skroniowych (FTLD) – najczęstsza przyczyna PPA (60-70% przypadków)1
  • Choroba Alzheimera – odpowiada za około 30-40% przypadków PPA12
  • Inne choroby neurodegeneracyjne, w tym otępienie z ciałami Lewy’ego i otępienie naczyniowe1

W przypadku pierwotnej afazji postępującej (PPA) dochodzi do zaniku (atrofii) określonych obszarów mózgu, głównie płatów czołowych, skroniowych lub ciemieniowych po lewej stronie. Objawy rozwijają się powoli, przez okres kilku lat.12 Wyróżnia się trzy główne podtypy PPA:

  • Wariant niepłynny/agramatyczny – zazwyczaj powodowany przez FTLD z patologią białka tau12
  • Wariant semantyczny – najczęściej związany z FTLD i akumulacją białka TDP-4312
  • Wariant logopeniczny – zwykle powodowany przez chorobę Alzheimera12

W przeciwieństwie do afazji spowodowanej udarem czy urazem, która często ulega poprawie z czasem, afazja w przebiegu chorób neurodegeneracyjnych ma charakter postępujący.1

Rzadsze przyczyny afazji

Istnieje również szereg mniej typowych przyczyn afazji:

  • Przemijający atak niedokrwienny (TIA) – tzw. mini-udar, może powodować przejściową afazję trwającą od kilku minut do kilku godzin. Osoby, które doświadczyły TIA, są w grupie zwiększonego ryzyka wystąpienia pełnoobjawowego udaru mózgu w przyszłości.12
  • Migrena – niektóre rodzaje migreny mogą powodować przemijające epizody afazji, które ustępują po zakończeniu ataku.12
  • Napady padaczkowe – mogą powodować przejściową afazję zarówno jako objaw prodromalny, jak i podczas samego napadu.12
  • Ropień zewnątrztwardówkowy – zakażenie powodujące ucisk na obszary mózgu odpowiedzialne za mowę.1
  • Operacje neurochirurgiczne – mogą powodować afazję jako powikłanie zabiegu.1
  • Niedotlenienie mózgu – różne stany prowadzące do hipoksji mózgu mogą powodować uszkodzenie obszarów językowych.1
  • Zespół Landaua-Kleffnera – rzadka przyczyna afazji u dzieci, określana jako napadowa afazja nabyta, związana z nieprawidłową aktywnością w zapisie EEG.1
  • Ekspozycja na toksyny i zatrucia – w tym zatrucie tlenkiem węgla czy zatrucie metalami ciężkimi.1
  • Choroby autoimmunologiczne – zarówno pierwotne, jak i wtórne do nowotworów (jako zespół paraneoplastyczny).1
  • Radioterapia i chemioterapia – mogą powodować uszkodzenie tkanki mózgowej.1

Czynniki ryzyka i genetyczne uwarunkowania afazji

Czynniki ryzyka afazji są ściśle powiązane z przyczynami tego zaburzenia. W przypadku afazji po udarze, czynniki ryzyka obejmują wszystkie czynniki predysponujące do udaru mózgu: nadciśnienie tętnicze, cukrzycę, hipercholesterolemię, palenie tytoniu, migotanie przedsionków, otyłość oraz brak aktywności fizycznej.1

Pierwotna afazja postępująca w większości przypadków nie ma podłoża genetycznego. Jednak w niewielkiej liczbie rodzin PPA może być spowodowana dziedzicznymi formami zwyrodnienia płatów czołowo-skroniowych. Najczęstszym genem związanym z rodzinnym występowaniem PPA jest gen progranulin (GRN). Inne, rzadziej występujące geny obejmują gen białka tau związanego z mikrotubulami (MAPT) oraz gen C9ORF72.12

Co ciekawe, badania wskazują, że czynniki ryzyka dla PPA różnią się od tych dla choroby Alzheimera. Największym genetycznym czynnikiem ryzyka dla choroby Alzheimera jest allel ApoE4, jednak badania sugerują, że nie jest on czynnikiem ryzyka dla PPA spowodowanej chorobą Alzheimera.1

Mechanizmy patofizjologiczne afazji

Afazja wynika z uszkodzenia specyficznych obszarów mózgu odpowiedzialnych za przetwarzanie i produkcję języka. Lokalizacja i rozległość uszkodzenia determinuje rodzaj i nasilenie objawów afazji.12

Lokalizacja uszkodzeń mróżgowych prowadzących do afazji

Obszary mózgu, których uszkodzenie najczęściej prowadzi do afazji, obejmują:12

  • Okolica Broki – zlokalizowana w dolnej części płata czołowego; uszkodzenie prowadzi do afazji Broki (ekspresyjnej/niepłynnej), charakteryzującej się trudnościami w produkcji mowy przy zachowanym względnie dobrym rozumieniu12
  • Okolica Wernickego – w górnej części płata skroniowego; uszkodzenie powoduje afazję Wernickego (receptywną/płynną), z zaburzonym rozumieniem mowy przy względnie zachowanej płynności wypowiedzi12
  • Pęczek łukowaty – wiązka włókien łącząca okolice Broki i Wernickego; uszkodzenie prowadzi do afazji przewodzeniowej, z charakterystycznymi trudnościami w powtarzaniu1
  • Inne struktury – uszkodzenie podkorowych struktur, takich jak wzgórze, torebka wewnętrzna i zewnętrzna oraz jądro ogoniaste prążkowia, również może powodować afazję1

W większości przypadków afazja wynika z uszkodzenia lewej półkuli mózgu, która u około 95% osób praworęcznych i 70% leworęcznych jest dominująca dla funkcji językowych. Jednak u około 30% osób leworęcznych dominacja językowa może znajdować się w prawej półkuli lub być obustronna.12

Patofizjologia pierwotnej afazji postępującej

W przypadku pierwotnej afazji postępującej (PPA), mechanizm patofizjologiczny związany jest z degeneracją komórek nerwowych spowodowaną gromadzeniem się nieprawidłowych białek w obszarach mózgu odpowiedzialnych za język.1 Główne mechanizmy patologiczne obejmują:

  • Gromadzenie się nieprawidłowego białka tau (FTLD-tau)1
  • Akumulację nieprawidłowego białka TDP-43 (FTLD-TDP-43)1
  • Zmiany patologiczne charakterystyczne dla choroby Alzheimera (złogi beta-amyloidu i splątki neurofibrylarne)1

W PPA dochodzi do zaniku (atrofii) określonych obszarów mózgu, głównie po lewej stronie – w płatach czołowych, skroniowych lub ciemieniowych. Ta atrofia prowadzi do stopniowego pogarszania się zdolności językowych.1

Mechanizmy kompensacyjne i plastyczność mózgu

Mózg posiada zdolność do reorganizacji po uszkodzeniu, co może prowadzić do częściowej poprawy funkcji językowych u osób z afazją. Ten proces, znany jako neuroplastyczność, polega na przejmowaniu funkcji uszkodzonych obszarów przez nieuszkodzone części mózgu.12

Badania wykazują, że po uszkodzeniu lewej półkuli mózgu, homologiczne obszary w prawej półkuli mogą przejąć część funkcji językowych. Dodatkowo, obszary otaczające uszkodzoną tkankę w lewej półkuli również mogą uczestniczyć w reorganizacji sieci językowej.1

Ta zdolność do neuroplastyczności jest podstawą dla terapii afazji, w tym terapii mowy, która ma na celu stymulowanie reorganizacji mózgu i poprawę funkcji językowych. Nowsze podejścia terapeutyczne, takie jak stymulacja przezczaszkowa prądem stałym czy stymulacja magnetyczna, mają wspierać te naturalne mechanizmy kompensacyjne mózgu.12

Czynniki wpływające na rokowanie w afazji

Rokowanie i potencjał poprawy w afazji zależy od wielu czynników, w tym przyczyny, rozległości uszkodzenia mózgu, wieku pacjenta oraz dostępności i intensywności terapii.12

Wpływ etiologii na rokowanie

Różne przyczyny afazji wiążą się z odmiennym rokowaniem:1

  • Afazja poudarowa – większość pacjentów doświadcza pewnej poprawy, szczególnie w pierwszych 3-6 miesiącach po udarze, choć poprawa może postępować nawet przez kilka lat1
  • Afazja po urazie mózgu – rokowanie zależy od rozległości i lokalizacji uszkodzenia; w lżejszych przypadkach możliwa jest znacząca poprawa1
  • Afazja spowodowana guzem mózgu – rokowanie zależy od skuteczności leczenia guza; w przypadku całkowitego usunięcia guza możliwa jest poprawa funkcji językowych1
  • Afazja w przebiegu infekcji mózgu – często ustępuje po skutecznym leczeniu infekcji, o ile nie doszło do rozległego uszkodzenia obszarów językowych1
  • Pierwotna afazja postępująca – ma charakter postępujący i nie ulega poprawie, choć tempo progresji może być różne; obecnie nie ma skutecznego leczenia powstrzymującego postęp choroby12
  • Przemijająca afazja – w przypadku TIA, migreny czy napadów padaczkowych afazja ma zwykle charakter całkowicie odwracalny i ustępuje po zakończeniu epizodu1

Rola farmakoterapii w leczeniu afazji

Badania nad farmakoterapią w leczeniu afazji wciąż trwają. Niektóre grupy leków wykazują potencjał w poprawie funkcji językowych u pacjentów z afazją:12

  • Agoniści dopaminy
  • Piracetam
  • Amfetaminy
  • Inhibitory cholinoesterazy (stosowane głównie w chorobie Alzheimera)
  • Memantyna
  • Donepezil

Skuteczność tych leków wykazano jednak głównie w małych badaniach, a ich rzeczywista rola w leczeniu afazji wymaga potwierdzenia w większych badaniach klinicznych.12

Nowe metody terapeutyczne

Oprócz konwencjonalnej terapii mowy, badane są nowe metody wspierające terapię afazji:1

  • Przezczaszkowa stymulacja magnetyczna – wykorzystuje pole magnetyczne do modyfikacji aktywności neuronów w określonych obszarach mózgu
  • Przezczaszkowa stymulacja elektryczna – stosuje słaby prąd elektryczny do stymulacji obszarów mózgu zaangażowanych w funkcje językowe

Te metody stosowane są zwykle w połączeniu z terapią mowy, aby wzmocnić mechanizmy neuroplastyczności i przyspieszyć proces zdrowienia.1 Jednak konieczne są większe badania kliniczne, aby potwierdzić ich skuteczność w porównaniu do samej terapii mowy.1

Podsumowanie etiologii afazji

Afazja jest zaburzeniem nabytym, zawsze wynikającym z uszkodzenia mózgu w obszarach odpowiedzialnych za funkcje językowe. Najczęstszą przyczyną jest udar mózgu, odpowiadający za około 25-40% przypadków afazji.12 Inne istotne przyczyny obejmują urazy czaszkowo-mózgowe, guzy mózgu, infekcje OUN oraz choroby neurodegeneracyjne, zwłaszcza pierwotną afazję postępującą.12

Lokalizacja i rozległość uszkodzenia mózgu determinują typ afazji i nasilenie objawów. Uszkodzenie okolicy Broki prowadzi do afazji niepłynnej, uszkodzenie okolicy Wernickego do afazji płynnej, a rozległe uszkodzenie obu tych obszarów do afazji globalnej.1

Rokowanie w afazji zależy głównie od jej przyczyny. Afazja poudarowa ma tendencję do stopniowej poprawy, zwłaszcza w pierwszych miesiącach po incydencie. Afazja w przebiegu chorób neurodegeneracyjnych ma natomiast charakter postępujący.12

Zrozumienie etiologii afazji ma kluczowe znaczenie dla właściwej diagnozy, planowania terapii oraz prognozowania przebiegu choroby. Współczesne badania koncentrują się na lepszym zrozumieniu mechanizmów neuroplastyczności oraz opracowaniu nowych metod terapeutycznych, które mogłyby poprawić rokowanie u pacjentów z afazją.1

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  1. 10.04.2026
  2. www.leksykon.com.pl

Materiały źródłowe

  • #1 Aphasia – StatPearls – NCBI Bookshelf
    https://www.ncbi.nlm.nih.gov/books/NBK559315/
    Aphasia is an acquired language disorder resulting from damage to the brain’s language centers located in the dominant hemisphere (usually the left). […] Although the primary cause of aphasia is stroke, particularly ischemic stroke, it can also result from traumatic brain injury, brain tumors, and neurodegenerative diseases. […] Stroke, particularly ischemic stroke affecting the dominant hemisphere within the vascular territory of the left middle cerebral artery (MCA), is the most common cause of aphasia. […] Other causes of aphasia include neurodegenerative diseases such as frontotemporal dementia or Alzheimer disease, TBI, or mass lesions in the brain, including primary or secondary brain tumors. […] Aphasia is always the result of an acquired brain lesion, and it differs from dysarthria, which refers to impairment in articulation.
  • #1 Aphasia | NIDCD
    https://www.nidcd.nih.gov/health/aphasia
    Aphasia is a disorder that results from damage (usually from a stroke or traumatic brain injury) to areas of the brain that are responsible for language. […] Stroke is the leading cause of aphasia. According to the National Aphasia Association, approximately one third of stroke survivors have aphasia. […] Aphasia can appear suddenly, following brain surgery or after a head injury, or it can develop gradually from the effects of a brain tumor (and associated treatments). Other causes of aphasia include brain infections. […] Different terminology is used to describe progressive causes of aphasia. When people have dementia (e.g., Alzheimers disease, frontotemporal dementia, or other types of dementia) that includes significant cognitive or behavioral changes, they may also develop aphasia as their disease progresses and begins to affect the language areas of the brain. […] PPA can be caused by different types of dementia, such as Alzheimers disease, vascular dementia, Lewy Body dementia, and frontotemporal dementia. Some subtypes of PPA are associated more commonly with particular types of dementia, but there is still much to learn about these relationships.
  • #1 What Are the Causes and Different Types of Aphasia?​
    https://www.aarp.org/health/conditions-treatments/info-2022/aphasia.html
    Aphasia is a condition that affects peoples ability to communicate. There are several different types of aphasia, which is usually caused by damage to an area on the left side of the brain that controls language and comprehension. […] Stroke is the most common cause of aphasia in the United States, Botha says. A transient ischemic attack (TIA), which happens when blood flow to the brain is temporarily blocked, can also cause short-term aphasia that goes away within a few hours or days. A severe head injury from, say, an accident can cause aphasia, as can a tumor. Aphasia can also develop slowly, usually caused by a progressive brain disease such as Alzheimers or another neurological disorder. […] Treatment almost always includes speech therapy, but the best treatment for aphasia depends on the underlying cause of the condition.
  • #1 What Causes Aphasia? Here’s What You Need to Know
    https://constanttherapyhealth.com/brainwire/aphasia-awareness-month-what-causes-aphasia/
    Just as there are many types of aphasia, there are many ways in which aphasia can be acquired. […] Aphasia is caused when the brain is damaged in areas that affect language comprehension and production. […] Aphasia can be caused by a number of different types of damage to the brain: […] Stroke – this is when a clot lodges somewhere in the brain and prevents blood-flow to other parts of the brain; this clot can come from other parts of the body, like the heart, or can develop in the brain itself […] Hemorrhagic Stroke – this occurs when a vessel bursts in the brain; blood is actually poisonous to the brain, so any area of the brain that is touched by blood will be damaged and the neurons (the cells in our brain) may die […] Aneurysm – an aneurysm is a ballooning of a vessel – if that balloon bursts, it will cause a hemorrhagic stroke
  • #1 What Is Expressive Aphasia And What Causes It?
    https://husbandandwifelawteam.com/blog/what-is-expressive-aphasia-and-what-causes-it
    Expressive aphasia, also known as Brocas aphasia, is a language disorder caused by damage to parts of the brain that control speaking and language comprehension. It can be triggered by certain medical conditions or brain injuries. […] Aphasia may occur as the result of strokes, dementia, or brain tumors. But it can also be caused by blunt force trauma to the head that results in a traumatic brain injury (TBI). […] According to the CDC, over 220,000 people are hospitalized for brain injuries every year. Events that may cause aphasia include: Slip and fall injuries, Automobile crashes, Motorcycle accidents, Truck accidents, Bicycle accidents, Sports injuries, Gunshot wounds and violent attacks.
  • #1 What Is Aphasia? Causes, Types and Treatments – PAM Health
    https://pamhealth.com/resources/what-is-aphasia-causes-types-and-treatments/
    Aphasia is almost always due to a brain injury, but the causes of that injury can vary. Anything that affects language production or comprehension areas of the brain can lead to aphasia. Possible causes include: […] Stroke: Strokes are the most common cause of aphasia. Strokes are also the fifth leading cause of death in the United States and often result in long-term disability. Each year, 750,000 strokes occur in the United States about a third of those cause aphasia. The connection between aphasia and stroke is more widespread than many realize. […] Head trauma: Injury-related trauma can damage areas of the brain important for speech and language. Traumatic brain injuries can be short- or long-term, depending on their severity. If a traumatic brain injury causes aphasia, it will likely cause other cognitive problems, as well. Though trauma is a less common cause than stroke, aphasia and head injury often go hand-in-hand.
  • #1 Aphasia – Symptoms & causes – Mayo Clinic
    https://www.mayoclinic.org/diseases-conditions/aphasia/symptoms-causes/syc-20369518
    Aphasia usually happens suddenly after a stroke or a head injury. But it can also come on gradually from a slow-growing brain tumor or a disease that causes progressive, permanent damage (degenerative). The severity of aphasia depends on a number of things, including the cause and the extent of the brain damage. […] The most common cause of aphasia is brain damage resulting from a stroke the blockage or rupture of a blood vessel in the brain. Loss of blood to the brain leads to brain cell death or damage in areas that control language. […] Brain damage caused by a severe head injury, a tumor, an infection or a degenerative process also can cause aphasia. In these cases, the aphasia usually occurs with other types of cognitive problems, such as memory problems or confusion. […] Primary progressive aphasia is the term used for language difficulty that develops gradually. This is due to the gradual degeneration of brain cells located in the language networks. Sometimes this type of aphasia will progress to a more generalized dementia.
  • #1 Aphasia – StatPearls – NCBI Bookshelf
    https://www.ncbi.nlm.nih.gov/books/NBK559315/
    Aphasia cannot be caused by diseases affecting the peripheral nervous system, neuromuscular junction, or muscles. […] Aphasia can also result from TBI and neurodegenerative disorders such as Alzheimer disease and frontotemporal dementia. […] Additional causes of injury to language areas include infections and mass effects from brain tumors.
  • #1 What Is Aphasia? Causes, Types and Treatments – PAM Health
    https://pamhealth.com/resources/what-is-aphasia-causes-types-and-treatments/
    Brain tumors: Because tumors are masses of growing cells, a brain tumor can harm the brains language centers. Resolving aphasia will depend on the cancer treatments success, though some people may experience long-term communication issues. With slow-growing tumors, the brain may be able to shift language processing to another area the brain has remarkable adaptability. […] Infections: In some cases, an infection may cause aphasia, though this is less common. Those with compromised immune systems are much likelier to have brain infections. An infection can lead to additional cognitive issues. […] Degenerative disorders: Degenerative disorders including Alzheimers disease may cause aphasia-like symptoms in language processing and communication. […] Migraines or seizures: Aphasia brought on by a migraine or seizure is temporary, lasting only during the episode.
  • #1 Aphasia – Wikipedia
    https://en.wikipedia.org/wiki/Aphasia
    Aphasia, also known as dysphasia, is an impairment in a person’s ability to comprehend or formulate language because of damage to specific brain regions. The major causes are stroke and head trauma; prevalence is hard to determine, but aphasia due to stroke is estimated to be 0.10.4% in developed countries. Aphasia can also be the result of brain tumors, epilepsy, autoimmune neurological diseases, brain infections, or neurodegenerative diseases (such as dementias). […] Aphasia is most often caused by stroke, where about a quarter of patients who experience an acute stroke develop aphasia. However, any disease or damage to the parts of the brain that control language can cause aphasia. Some of these can include brain tumors, traumatic brain injury, epilepsy and progressive neurological disorders. In rare cases, aphasia may also result from herpesviral encephalitis. The herpes simplex virus affects the frontal and temporal lobes, subcortical structures, and the hippocampal tissue, which can trigger aphasia.
  • #1 Aphasia Triggered by Brain Infection | The Aphasia Library
    https://www.aphasia.com/aphasia-library/what-causes-aphasia/brain-infection/
    Although less common than strokes and brain injuries, aphasia can also be caused by an infection in the brain. Any infection that damages or impacts the brains language centers can cause aphasia and language impairments. […] Brain infections can cause aphasia if the infection or swelling impacts the brains language centers. Aphasia due to brain infection is often short-term and gets better when the infection is cleared. However, if the infection is severe, long-term aphasia can result. […] Aphasia is likely to resolve if the brain infection is addressed quickly and treated.
  • #1 Types of aphasia | Stroke Association
    https://www.stroke.org.uk/stroke/effects/aphasia/types-of-aphasia
    There are different types of aphasia, and someone can have more than one type. […] Another type of aphasia is primary progressive aphasia (PPA), which unlike the other types of aphasia is degenerative, meaning it gets worse over time. […] Expressive aphasia, also called non-fluent aphasia or Brocas aphasia, is due to damage in the Brocas area of the brain. […] Receptive aphasia, also called Wernickes or fluent aphasia, is due to damage to the Wernickes area in the brain. […] Anomia, or anomic aphasia, is a milder form of aphasia. […] Global aphasia is the most severe form of aphasia, and its due to damage in several language areas of the brain including Brocas and Wernickes. […] Primary progressive aphasia (PPA) is a condition where language capabilities become slowly and progressively worse, leading to a gradual loss of the ability to: Read. Write. Speak. Understand what other people are saying. […] Deterioration can happen slowly, over a period of years. […] It’s important to get an accurate diagnosis for PPA. […] There is no cure for PPA.
  • #1
    https://www.brain.northwestern.edu/dementia/primary-progressive-aphasia/symptoms-causes.html
    The symptoms of PPA occur when brain cells malfunction in language-related parts of the brain due to the accumulation of abnormal proteins. […] The underlying diseases causing PPA are called „neurodegenerative” because they cause gradually progressive brain cell death that cannot be attributed to other causes, such as head trauma, infection, stroke or cancer. […] There are several types of neurodegeneration that can cause PPA. The three most commonly encountered types are: Frontotemporal lobar degeneration with abnormal tau protein accumulation (FTLD-tau), Frontotemporal lobar degeneration with abnormal TDP-43 accumulation (FTLD-TDP-43), and Alzheimers disease (AD). […] When abnormal proteins from AD or one of the forms of FTLD attack the language areas of the brain, PPA results. PPA is caused by AD in approximately 30 to 40 percent of cases and by one of the forms of FTLD in approximately 60 to 70 percent of cases.
  • #1 Primary Progressive Aphasia Causes and Diagnoses | Northwestern Medicine
    https://www.nm.org/conditions-and-care-areas/neurosciences/primary-progressive-aphasia/causes-and-diagnoses
    PPA arises when nerve cells in language-related parts of the brain malfunction. The underlying diseases are called degenerative because they cause gradually progressive nerve cell death that cannot be attributed to other causes such as head trauma, infection, stroke or cancer. There are several types of neurodegeneration that can cause PPA. […] PPA is caused by AD in approximately 30-40 percent of cases and by FTLD in approximately 60-70 percent of cases. In contrast, PPA is a very rare manifestation of AD. […] PPA is therefore said to be an atypical consequence of AD. […] Sometimes these abnormalities become concentrated in language areas (instead of memory areas) of the brain and become the cause of PPA. […] In the vast majority of individuals, PPA is not genetic. However, in a small number of families, PPA can be caused by hereditary forms of FTLD.
  • #1 Primary progressive aphasia – Symptoms and causes – Mayo Clinic
    https://www.mayoclinic.org/diseases-conditions/primary-progressive-aphasia/symptoms-causes/syc-20350499
    Primary progressive aphasia is caused by a shrinking of certain areas of the brain, known as lobes. In primary progressive aphasia, the frontal, temporal or parietal lobes are affected. When areas of the brain shrink, it’s called atrophy. The atrophy caused by primary progressive aphasia mainly happens on the left side of the brain. The areas affected are responsible for speech and language. […] Atrophy is linked to the presence of certain proteins in the brain. The proteins may reduce brain activity or function.
  • #1 Primary progressive aphasia involves many losses: Here’s what you need to know – Harvard Health
    https://www.health.harvard.edu/blog/progressive-aphasia-involves-many-losses-heres-what-you-need-to-know-202204132723
    Aphasia is a disorder of language because of injury to the brain. Strokes (when a blood clot blocks off an artery and a part of the brain dies) are the most common cause, although aphasia may also be caused by traumatic brain injuries, brain tumors, encephalitis, and almost anything else that damages the brain, including neurodegenerative diseases. […] Neurodegenerative diseases are disorders that slowly and relentlessly damage the brain. […] Different neurodegenerative diseases damage different parts of the brain and cause different symptoms. When a neurodegenerative disease causes problems with language first and foremost, it is called primary progressive aphasia. […] The logopenic variant of primary progressive aphasia is usually caused by Alzheimer’s disease. […] The semantic variant of primary progressive aphasia is usually caused by frontotemporal lobar degeneration, and specifically by accumulation of TDP-43. […] The nonfluent/agrammatic variant of primary progressive is also usually caused by frontotemporal lobar degeneration, but this time it is most often due to tau pathology.
  • #1 Aphasia Causes, Symptoms,Treatment | Froedtert & MCW
    https://www.froedtert.com/aphasia
    Aphasia can be a sign of a significant and serious problem, such as a stroke. […] The most common cause of aphasia is a stroke or brain injury to the left side of the brain. Aphasia can also occur from damage to other parts of the brain, but that is less common. The causes of brain damage can vary and include: Ischemic and hemorrhagic stroke, Burst aneurysms, Infection, Traumatic brain injury. […] Aphasia caused by one of these conditions typically does not get worse over time, but rather, you can make a continued recovery over the years following the injury or occurrence. Aphasia can also come on gradually from a slow-growing brain tumor or from progressive damage related to dementia such as language-variant frontal-temporal dementias or primary progressive aphasias. […] In cases where aphasia is related to progressive dementia, the aphasia symptoms tend to worsen over time.
  • #1 Aphasia – Symptoms & causes – Mayo Clinic
    https://www.mayoclinic.org/diseases-conditions/aphasia/symptoms-causes/syc-20369518
    Sometimes temporary episodes of aphasia can occur. These can be due to migraines, seizures or a transient ischemic attack (TIA). A transient ischemic attack (TIA) occurs when blood flow is temporarily blocked to an area of the brain. People who’ve had a TIA are at an increased risk of having a stroke in the near future.
  • #1 Aphasia – Wikipedia
    https://en.wikipedia.org/wiki/Aphasia
    Substantial damage to tissue anywhere within the region shown in blue (on the figure in the infobox above) can potentially result in aphasia. Aphasia can also sometimes be caused by damage to subcortical structures deep within the left hemisphere, including the thalamus, the internal and external capsules, and the caudate nucleus of the basal ganglia. […] Primary progressive aphasia (PPA), while its name can be misleading, is actually a form of dementia that has some symptoms closely related to several forms of aphasia. It is characterized by a gradual loss in language functioning while other cognitive domains are mostly preserved, such as memory and personality. PPA usually initiates with sudden word-finding difficulties in an individual and progresses to a reduced ability to formulate grammatically correct sentences (syntax) and impaired comprehension. The etiology of PPA is not due to a stroke, traumatic brain injury (TBI), or infectious disease; it is still uncertain what initiates the onset of PPA in those affected by it. […] Epilepsy can also include transient aphasia as a prodromal or episodic symptom. However, the repeated seizure activity within language regions may also lead to chronic, and progressive aphasia.
  • #1 Transient Aphasia: Causes of Temporary Aphasia
    https://www.griswoldcare.com/blog/transient-aphasia-causes-of-temporary-aphasia/
    Aphasia can occur anytime the speech center of your brain is obstructed in some way. […] Permanent aphasia is the result of brain damage, while transient aphasia can be caused by any number of fleeting environmental conditions. […] Although most cases of temporary aphasia are the result of migraines, aphasia can be caused by any number of things that create electrical interference in the brain. […] Sometimes called a mini-stroke, TIA describes when blood becomes blocked to a part of the brain for several minutes. […] Suffering from a transient ischemic attack means you’re at much greater risk of stroke, which is the most common preventable cause of permanent aphasia. […] Temporary aphasia can also be caused by an extradural abscess, which is an infection causing pressure on the speech center of the brain. […] Even seizures produce electrical interference, causing temporary aphasia. […] Transient expressive aphasia is a special form of aphasia that can occur when someone travels to a high altitude.
  • #1 Broca’s aphasia: Symptoms, causes, and treatment
    https://www.medicalnewstoday.com/articles/brocas-aphasia
    Brocas aphasia is a subtype that causes difficulty with fluent, spontaneous speech. […] The most common cause of Brocas aphasia is a stroke in the inferior frontal lobe or the Broca area. […] Other potential causes include traumatic brain injuries, brain infections, or tumors. […] If there is an injury to the Broca area, communication breaks down between a person’s thoughts and language abilities. […] Less commonly, brain surgery can cause Brocas aphasia as a complication. […] The most common cause of Brocas aphasia is a stroke. Some people develop the condition due to a brain injury, tumor, or infection.
  • #1 Aphasia: Understanding Its Symptoms, Types, Causes, and Treatments | IBS Hospital
    https://www.ibshospitals.com/blog/aphasia-understanding-its-symptoms-types-causes-and-treatments
    Damage to the language centres of the brain causes a condition called aphasia, an acquired language disease marked by difficulties with understanding, verbal or written communication, or both. […] While stroke, especially ischaemic stroke (when the cause of brain tissue damage is impaired blood supply), is the leading cause of aphasia, other causes include brain tumours, neurodegenerative conditions, and traumatic brain injury (TBI). […] Aphasia is brought on by damage to the language centre of the brain, involving the parts of the brain that regulate language. The following are the most typical causes of aphasia: Stroke, Traumatic brain injury (TBI), Brain tumor, Brain inflammation, Brain infection, Progressive neurological conditions like dementia and Alzheimers disease. […] Any disorder that damages the brain can cause aphasia. It can also occur when you have issues that interfere with your brain’s normal functioning. Other potential reasons are as follows: Aneurysms, Cerebral hypoxia, Brain surgery, Concussion, Epilepsy, Congenital (present at birth) conditions, Genetic conditions like Wilsons disease, Radiation therapy, Chemotherapy, Migraines, Toxins and poisons (such as carbon monoxide poisoning or heavy metal poisoning), Transient ischemic attacks (TIAs).
  • #1 Aphasia Clinical Presentation: History, Physical, Causes
    https://emedicine.medscape.com/article/1135944-clinical
    A rare cause of aphasia in children is the Landau-Kleffner syndrome, a syndrome of acquired epileptic aphasia. Symptoms begin in childhood and progress; electroencephalographic (EEG) findings confirm the diagnosis. The syndrome is treatable; however, in some patients, the seizures are controlled more than the aphasia is. […] A rare but important condition not to overlook is herpes simplex encephalitis. The aphasia in herpes simplex encephalitis may mimic Wernicke aphasia mimicking a stroke deficit, but often with associated confusion. The disease usually presents with confusion, fever, headache, and seizures. Over time, the MRI usually shows a classic insula-sparing lesion, involving one or both temporal lobes. Early treatment with antiviral agents is crucial to prevent further injury until the diagnosis can be confirmed, usually by PCR testing of spinal fluid.
  • #1 Expressive aphasia – Wikipedia
    https://en.wikipedia.org/wiki/Expressive_aphasia
    Expressive aphasia is caused by acquired damage to the frontal regions of the brain, such as Broca’s area. […] The most common cause of expressive aphasia is stroke. A stroke is caused by hypoperfusion (lack of oxygen) to an area of the brain, which is commonly caused by thrombosis or embolism. […] Expressive aphasia can also be caused by trauma to the brain, tumor, cerebral hemorrhage and by extradural abscess. […] Less common causes of expressive aphasia include primary autoimmune phenomenon and autoimmune phenomenon that are secondary to cancer (as a paraneoplastic syndrome) have been listed as the primary hypothesis for several cases of aphasia, especially when presenting with other psychiatric disturbances and focal neurological deficits. […] Neurodegenerative disorders may present with aphasia. Alzheimer’s disease may present with either fluent aphasia or expressive aphasia. There are case reports of Creutzfeldt-Jakob disease presenting with expressive aphasia.
  • #1 Aphasia Symptoms, Causes & Treatment | Baptist Health
    https://www.baptisthealth.com/care-services/conditions-treatments/aphasia
    Aphasia results from damage to the brains centers of communication. This damage can occur abruptly, by means of a stroke or head injury, or more gradually, by means of a tumor or a degenerative disease, such as dementia. Stroke is the most common cause. The National Aphasia Association estimates that between one-quarter to four-tenths of all stroke survivors develop a form of aphasia. […] Risk factors for aphasia vary by individual and also depend on unforeseen circumstances, such as the likelihood of a serious accident. However, steps taken to avoid a stroke, including healthy diet, regular exercise, adequate sleep, stress control, and tobacco cessation, also reduce the possibility of stroke-related aphasia.
  • #1
    https://www.brain.northwestern.edu/dementia/primary-progressive-aphasia/symptoms-causes.html
    There is no one-to-one relationship between PPA subtype and underlying pathology. However, PPA-S (semantic variant) is most commonly associated with FTLD-TDP; PPA-G (agrammatic/nonfluent variant) is most commonly FTLD-tau; and PPA-L (logopenic variant) is most commonly associated with AD. […] In the vast majority of individuals, PPA is not genetic. However, in a small number of families, PPA can be caused by hereditary forms of FTLD. The most common gene implicated in these families is the progranulin gene (GRN). Other, less-common genes implicated in FTLD include the microtubule associated protein tau (MAPT) and chromosome 9 open reading frame 72 (C9ORF72). […] The risk factors for PPA seem to be different than that of Alzheimer’s disease dementia. The biggest genetic risk factor for Alzheimer’s disease dementia is ApoE4. However, research evidence indicates that ApoE4 is not a risk factor for PPA caused by AD.
  • #1 Aphasia
    https://www.asha.org/practice-portal/clinical-topics/aphasia/?srsltid=AfmBOoqq8dHxPjupOIZgJ0CdSxIZpRvgD0VS_kNpTzQtnIOGBBrne4hn
    Aphasia is an acquired neurogenic language disorder resulting from an injury to the brain, typically the left hemisphere, that affects the functioning of core elements of the language network. […] Aphasia may also result from neurodegenerative disease. For example, primary progressive aphasia is a subtype of frontotemporal dementia in which language capabilities become progressively impaired. […] Aphasia is caused by damage to the language network of the brain. Aphasia typically results from left-hemisphere damage. However, in rare instances, aphasia can occur with a right-hemisphere lesion. This happens most often in people who are left-handed because left-handed individuals are more likely to have language networks that are bilateral or that are located in the right hemisphere. […] Common causes of aphasia include the following: stroke, traumatic brain injury, brain tumors, brain surgery, brain infections.
  • #1 Wernicke’s Aphasia: Symptoms, Causes, and Treatment
    https://www.healthline.com/health/wernickes-aphasia
    Wernickes aphasia is the loss of the ability to speak and understand language. It occurs when a small area the the left middle side of the brain called the Wernickes area is damaged. […] Wernickes aphasia causes difficulty speaking in coherent sentences or understanding others speech. […] Wernickes aphasia is the most common type of fluent aphasia. It occurs when the left middle side of the brain becomes damaged or altered. This part of the brain is known as Wernickes area, named after Carl Wernicke, a neurologist. Wernickes area of the brain controls human language. […] Lesions or damage in the middle of the left side of the brain causes Wernickes aphasia. […] Stroke is one potential cause of this condition because it impairs blood flow to the brain. If blood does not reach Wernickes area of the brain, it can kill brain cells, resulting in this type of aphasia. Aphasia affects 25 to 40 percent of people who experience strokes. […] Other conditions that may affect this area of the brain include head trauma, tumors, infections, and neurological disorders. […] Its also possible to have aphasia that comes and goes. This may be caused by migraines, seizures, or other medical conditions.
  • #1 Conduction Aphasia: Symptoms, Examples, & Treatment
    https://www.flintrehab.com/conduction-aphasia/?srsltid=AfmBOopfSTGhzumGWrxshxj8PQFHZksuB_UVdS3DiJ2QyNKTMqwKPyXw
    Conduction aphasia is traditionally understood to be caused by damage to a particular area of the brain, like after a stroke or brain injury. […] In this case, damage to the area of the brain related to conduction aphasia is usually damage to the arcuate fasciculus, a white matter tract that runs between Brocas and Wernickes area. […] Damage to the arcuate fasciculus limits communication between those two areas. […] These two main language centers of the brain usually reside in the left hemisphere. As a result, aphasia is more common after a left hemisphere stroke or left hemisphere brain injury. […] Symptoms of conduction aphasia are mostly transient, lasting anywhere from a few hours or days. […] However, in more severe cases, conduction aphasia can last much longer, and some patients might display prolonged, profound deficits. […] Conduction aphasia is a mild form of aphasia that causes difficulties with repeating words or phrases. It occurs due to a disconnect in the language-processing and language-producing areas of the brain.
  • #1 What is Aphasia? Neurologist Explains Types, Causes, Symptoms and Treatment Back ButtonFilter Button
    https://mydoctor.kaiserpermanente.org/mas/news/what-is-aphasia-neurologist-explains-types-causes-symptoms-and-treatment-2017415
    Aphasia is caused by damage to the side of the brain that controls language. For most people this is the left hemisphere of the brain – but it is the right hemisphere in the almost 30 percent of people who are left-handed. The most common cause of aphasia is stroke. Other causes include traumatic brain injury, brain tumor and encephalitis, which is inflammation of the brain caused by infection. […] Dementia can also cause aphasia. In Alzheimer’s disease, the most common type of dementia, aphasia usually occurs later in the disease course. However, for patients with frontotemporal dementia, which constitutes about 15 percent of all dementias, language function may be the first one to deteriorate and slowly worsen over time. […] Though there is no cure for aphasia caused by loss of brain tissue, aphasia can be reversed in cases where infection or brain inflammation caused aphasia. Also, aphasia caused by brain tissue damage as the result of a stroke or trauma, for example, can eventually improve in patients.
  • #1 Evaluation of aphasia – Differential diagnosis of symptoms | BMJ Best Practice US
    https://bestpractice.bmj.com/topics/en-us/973
    Aphasia is an acquired impairment of language that affects comprehension and production of words, sentences, and/or discourse. […] It is typically characterized by errors in word retrieval or selection, including: […] An important variable that complicates these deficit associations is the remarkable reorganization of structure-function relationships that often occurs after brain lesions, such that undamaged parts of the brain assume the functions of the damaged part over time, resulting in recovery from even the most severe aphasias (usually only after appropriate language therapy). […] After identifying and treating the underlying cause of aphasia, such as acute stroke or herpes encephalitis, patients may have a residual aphasia. […] Therapy might be augmented with medications, such as memantine or donepezil, or with transcranial direct current stimulation. […] Larger randomized controlled trials are needed to determine whether these interventions have a significant benefit over speech and language therapy alone.
  • #1 Aphasia Causes, Symptoms,Treatment | Froedtert & MCW
    https://www.froedtert.com/aphasia
    Aphasia may develop slowly over time due to a form of dementia. This is different from when aphasia happens after a brain injury like a stroke or TBI. […] Research is studying the use of different medications for treatment of aphasia. Dopamine agonists, piracetam, amphetamines and anticholinesterase inhibitors have shown varying effectiveness in small studies for the treatment of aphasia. […] Brain stimulation is currently being studied as a treatment method when paired with speech therapy. Transcranial magnetic stimulation uses magnetic fields, and transcranial electrical stimulation uses a weak electrical current to the scalp. Both try to alter the way neurons fire in a specific region of the brain.
  • #1 Aphasia: Practice Essentials, Background, Pathophysiology
    https://emedicine.medscape.com/article/1135944-overview
    Aphasia is an acquired disorder of language due to brain damage. It may occur secondary to brain injury or degeneration and involves the left cerebral hemisphere to a greater extent than the right. […] Most aphasias and related disorders are due to stroke, head injury, cerebral tumors, or degenerative diseases. […] Stroke is likely the most common cause of aphasia, and it has been estimated that about 20-30% of stroke patients develop aphasia. […] The prognosis for life in a patient with aphasia depends on the cause of the aphasia. […] The prognosis for language recovery varies depending on the size and nature of the lesion and the age and overall health of the patient.
  • #1 Aphasia: Prognosis and treatment – UpToDate
    https://www.uptodate.com/contents/aphasia-prognosis-and-treatment
    Aphasia is a loss of ability to produce or understand language. The most common cause of aphasia is cerebrovascular disease, particularly cerebral infarction. Aphasia complicates 15 to 38 percent of ischemic strokes. Other structural pathologies (infection, trauma, neoplasm) and certain neurodegenerative diseases (primary progressive aphasia) can also cause aphasia. […] The prognosis for aphasia recovery depends in large part upon the underlying etiology. This has been best studied in cerebrovascular disease. Most patients with poststroke aphasia improve to some extent.
  • #1 Aphasia: What to Know
    https://www.webmd.com/brain/aphasia-causes-symptoms-types-treatments
    Aphasia is usually caused by a stroke or brain injury with damage to one or more parts of the brain that deal with language. According to the National Aphasia Association, about one-third of people who survive a stroke get aphasia. A stroke happens when a blood clot or a leaking or burst vessel cuts off blood flow to part of your brain, causing brain cells to die. […] Besides a stroke, other causes include: Head injury, Brain tumor, Infection, Dementia. […] In some cases, aphasia is a symptom of epilepsy or another neurological disorder. As of today, experts aren’t sure if aphasia can cause you to completely lose language structure, or if it only affects your ability to access language and use it. […] Sometimes aphasia happens in temporary episodes because of: Migraine, Transient ischemic attack (TIA), when blood flow is temporarily blocked to an area of the brain.
  • #1 What is Aphasia? – The National Aphasia Association
    https://aphasia.org/what-is-aphasia/
    APHASIA is a result of a STROKE or BRAIN INJURY, and affects a persons ability to communicate. […] Aphasia is always due to injury to the brain-most commonly from a stroke, particularly in older individuals. […] But brain injuries resulting in aphasia may also arise from head trauma, from brain tumors, or from infections. […] The most common cause of aphasia is stroke (about 25-40% of stroke survivors acquire aphasia). It can also result from head injury, brain tumor or other neurological causes. […] Primary Progressive Aphasia (PPA) is caused by neurodegenerative diseases, such as Alzheimer’s Disease or Frontotemporal Lobar Degeneration. […] When a person acquires aphasia it is usually due to damage on the left side of the brain, which controls movements on the right side of the body.
  • #2 Aphasia
    https://www.asha.org/practice-portal/clinical-topics/aphasia/?srsltid=AfmBOoqq8dHxPjupOIZgJ0CdSxIZpRvgD0VS_kNpTzQtnIOGBBrne4hn
    Aphasia is an acquired neurogenic language disorder resulting from an injury to the brain, typically the left hemisphere, that affects the functioning of core elements of the language network. […] Aphasia may also result from neurodegenerative disease. For example, primary progressive aphasia is a subtype of frontotemporal dementia in which language capabilities become progressively impaired. […] Aphasia is caused by damage to the language network of the brain. Aphasia typically results from left-hemisphere damage. However, in rare instances, aphasia can occur with a right-hemisphere lesion. This happens most often in people who are left-handed because left-handed individuals are more likely to have language networks that are bilateral or that are located in the right hemisphere. […] Common causes of aphasia include the following: stroke, traumatic brain injury, brain tumors, brain surgery, brain infections.
  • #2 What is Aphasia? – The National Aphasia Association
    https://aphasia.org/what-is-aphasia/
    APHASIA is a result of a STROKE or BRAIN INJURY, and affects a persons ability to communicate. […] Aphasia is always due to injury to the brain-most commonly from a stroke, particularly in older individuals. […] But brain injuries resulting in aphasia may also arise from head trauma, from brain tumors, or from infections. […] The most common cause of aphasia is stroke (about 25-40% of stroke survivors acquire aphasia). It can also result from head injury, brain tumor or other neurological causes. […] Primary Progressive Aphasia (PPA) is caused by neurodegenerative diseases, such as Alzheimer’s Disease or Frontotemporal Lobar Degeneration. […] When a person acquires aphasia it is usually due to damage on the left side of the brain, which controls movements on the right side of the body.
  • #2 Understanding aphasia and its cause – Mayo Clinic Health System
    https://www.mayoclinichealthsystem.org/hometown-health/speaking-of-health/aphasia-putting-the-disorder-into-words
    A stroke and its subsequent brain damage is the most common cause of aphasia. A stroke results from the bursting or blockage of blood vessels supplying the brain. This reduces blood flow to the brain, depriving the brain of essential nutrients and oxygen needed to support brain cell life. When a stroke occurs, the brain’s language centers can be affected if they don’t receive essential components like blood and oxygen. […] Aphasia also can develop due to a brain tumor, infection or degenerative disease. There always is an underlying cause of aphasia, which determines the severity of the person’s language difficulties. […] Temporary aphasia can appear during a migraine. It can occur from a seizure or transient ischemic attack, or TIA, sometimes called a mini-stroke. Anyone who experiences a TIA is at an elevated risk for a full-blown stroke in the future.
  • #2 Types of Aphasia | American Stroke Association
    https://www.stroke.org/en/about-stroke/effects-of-stroke/communication-and-aphasia/stroke-and-aphasia/types-of-aphasia
    A stroke that occurs in areas of the brain that control speech and language can result in aphasia, a disorder that affects your ability to speak, read, write and listen. […] Different aspects of language are in different parts of the left side of the brain. The type of aphasia you might experience depends on which part of your brain was affected by the stroke. […] A stroke that affects an extensive portion of your front and back regions of the left hemisphere may result in Global Aphasia.
  • #2 What Causes Aphasia? Here’s What You Need to Know
    https://constanttherapyhealth.com/brainwire/aphasia-awareness-month-what-causes-aphasia/
    Traumatic Brain Injury (TBI) – a TBI can cause aphasia, depending on what part of the head was hit and then what part of the brain was damaged […] Tumor – a tumor in the brain can cause aphasia if it grows in or presses upon a language region of the brain […] Disease – some neurological diseases can damage the brain and can result in aphasia, depending upon where that damage happens.
  • #2 Aphasia Causes, Symptoms,Treatment | Froedtert & MCW
    https://www.froedtert.com/aphasia
    Aphasia can be a sign of a significant and serious problem, such as a stroke. […] The most common cause of aphasia is a stroke or brain injury to the left side of the brain. Aphasia can also occur from damage to other parts of the brain, but that is less common. The causes of brain damage can vary and include: Ischemic and hemorrhagic stroke, Burst aneurysms, Infection, Traumatic brain injury. […] Aphasia caused by one of these conditions typically does not get worse over time, but rather, you can make a continued recovery over the years following the injury or occurrence. Aphasia can also come on gradually from a slow-growing brain tumor or from progressive damage related to dementia such as language-variant frontal-temporal dementias or primary progressive aphasias. […] In cases where aphasia is related to progressive dementia, the aphasia symptoms tend to worsen over time.
  • #2 Aphasia Clinical Presentation: History, Physical, Causes
    https://emedicine.medscape.com/article/1135944-clinical
    Aphasia is a symptom and not a disease; it can occur in a variety of types of brain injury and pathology. […] In stroke, the deficit is usually sudden and obvious. […] In substantial head trauma, the deficits may be unrecognized. Exceptions involve hemorrhages or traumatic contusions directly disrupting the left hemisphere language cortex, which may then resemble stroke syndromes. […] Language disorders in dementia take a variety of forms. In dementia, the language problem may be insidious and may require elicitation with the assistance of an experienced physician, speech/language pathologist, or neuropsychologist. Some dementias present with aphasic syndromes that closely resemble the aphasic stroke syndromes described above, except that they begin gradually and progressively worsen. If aphasia is the sole deficit over a 2-year period, the term primary progressive aphasia can be used, though many of these patients develop other cognitive deficits over time.
  • #2 Aphasia – StatPearls – NCBI Bookshelf
    https://www.ncbi.nlm.nih.gov/books/NBK559315/
    Aphasia is an acquired language disorder resulting from damage to the brain’s language centers located in the dominant hemisphere (usually the left). […] Although the primary cause of aphasia is stroke, particularly ischemic stroke, it can also result from traumatic brain injury, brain tumors, and neurodegenerative diseases. […] Stroke, particularly ischemic stroke affecting the dominant hemisphere within the vascular territory of the left middle cerebral artery (MCA), is the most common cause of aphasia. […] Other causes of aphasia include neurodegenerative diseases such as frontotemporal dementia or Alzheimer disease, TBI, or mass lesions in the brain, including primary or secondary brain tumors. […] Aphasia is always the result of an acquired brain lesion, and it differs from dysarthria, which refers to impairment in articulation.
  • #2
    https://www.nbcnews.com/health/health-news/aphasia-causes-symptoms-treatment-bruce-willis-rcna22261
    „A lot of people have sort of a very slow and insidious onset of aphasia,” Boxer said. […] If the person has primary progressive aphasia, or PPA, loss of speech is due to the „deterioration of brain tissue” caused by Alzheimer’s or dementia, and in that case, „other problems associated with the underlying disease, such as memory loss, often occur later,” the National Aphasia Association said.
  • #2 Aphasia – StatPearls – NCBI Bookshelf
    https://www.ncbi.nlm.nih.gov/books/NBK559315/
    Aphasia cannot be caused by diseases affecting the peripheral nervous system, neuromuscular junction, or muscles. […] Aphasia can also result from TBI and neurodegenerative disorders such as Alzheimer disease and frontotemporal dementia. […] Additional causes of injury to language areas include infections and mass effects from brain tumors.
  • #2 Primary Progressive Aphasia Causes and Diagnoses | Northwestern Medicine
    https://www.nm.org/conditions-and-care-areas/neurosciences/primary-progressive-aphasia/causes-and-diagnoses
    PPA arises when nerve cells in language-related parts of the brain malfunction. The underlying diseases are called degenerative because they cause gradually progressive nerve cell death that cannot be attributed to other causes such as head trauma, infection, stroke or cancer. There are several types of neurodegeneration that can cause PPA. […] PPA is caused by AD in approximately 30-40 percent of cases and by FTLD in approximately 60-70 percent of cases. In contrast, PPA is a very rare manifestation of AD. […] PPA is therefore said to be an atypical consequence of AD. […] Sometimes these abnormalities become concentrated in language areas (instead of memory areas) of the brain and become the cause of PPA. […] In the vast majority of individuals, PPA is not genetic. However, in a small number of families, PPA can be caused by hereditary forms of FTLD.
  • #2
    https://www.brain.northwestern.edu/dementia/primary-progressive-aphasia/symptoms-causes.html
    The symptoms of PPA occur when brain cells malfunction in language-related parts of the brain due to the accumulation of abnormal proteins. […] The underlying diseases causing PPA are called „neurodegenerative” because they cause gradually progressive brain cell death that cannot be attributed to other causes, such as head trauma, infection, stroke or cancer. […] There are several types of neurodegeneration that can cause PPA. The three most commonly encountered types are: Frontotemporal lobar degeneration with abnormal tau protein accumulation (FTLD-tau), Frontotemporal lobar degeneration with abnormal TDP-43 accumulation (FTLD-TDP-43), and Alzheimers disease (AD). […] When abnormal proteins from AD or one of the forms of FTLD attack the language areas of the brain, PPA results. PPA is caused by AD in approximately 30 to 40 percent of cases and by one of the forms of FTLD in approximately 60 to 70 percent of cases.
  • #2 Types of aphasia | Stroke Association
    https://www.stroke.org.uk/stroke/effects/aphasia/types-of-aphasia
    There are different types of aphasia, and someone can have more than one type. […] Another type of aphasia is primary progressive aphasia (PPA), which unlike the other types of aphasia is degenerative, meaning it gets worse over time. […] Expressive aphasia, also called non-fluent aphasia or Brocas aphasia, is due to damage in the Brocas area of the brain. […] Receptive aphasia, also called Wernickes or fluent aphasia, is due to damage to the Wernickes area in the brain. […] Anomia, or anomic aphasia, is a milder form of aphasia. […] Global aphasia is the most severe form of aphasia, and its due to damage in several language areas of the brain including Brocas and Wernickes. […] Primary progressive aphasia (PPA) is a condition where language capabilities become slowly and progressively worse, leading to a gradual loss of the ability to: Read. Write. Speak. Understand what other people are saying. […] Deterioration can happen slowly, over a period of years. […] It’s important to get an accurate diagnosis for PPA. […] There is no cure for PPA.
  • #2
    https://www.brain.northwestern.edu/dementia/primary-progressive-aphasia/symptoms-causes.html
    There is no one-to-one relationship between PPA subtype and underlying pathology. However, PPA-S (semantic variant) is most commonly associated with FTLD-TDP; PPA-G (agrammatic/nonfluent variant) is most commonly FTLD-tau; and PPA-L (logopenic variant) is most commonly associated with AD. […] In the vast majority of individuals, PPA is not genetic. However, in a small number of families, PPA can be caused by hereditary forms of FTLD. The most common gene implicated in these families is the progranulin gene (GRN). Other, less-common genes implicated in FTLD include the microtubule associated protein tau (MAPT) and chromosome 9 open reading frame 72 (C9ORF72). […] The risk factors for PPA seem to be different than that of Alzheimer’s disease dementia. The biggest genetic risk factor for Alzheimer’s disease dementia is ApoE4. However, research evidence indicates that ApoE4 is not a risk factor for PPA caused by AD.
  • #2 What Are the Causes and Different Types of Aphasia?​
    https://www.aarp.org/health/conditions-treatments/info-2022/aphasia.html
    Aphasia is a condition that affects peoples ability to communicate. There are several different types of aphasia, which is usually caused by damage to an area on the left side of the brain that controls language and comprehension. […] Stroke is the most common cause of aphasia in the United States, Botha says. A transient ischemic attack (TIA), which happens when blood flow to the brain is temporarily blocked, can also cause short-term aphasia that goes away within a few hours or days. A severe head injury from, say, an accident can cause aphasia, as can a tumor. Aphasia can also develop slowly, usually caused by a progressive brain disease such as Alzheimers or another neurological disorder. […] Treatment almost always includes speech therapy, but the best treatment for aphasia depends on the underlying cause of the condition.
  • #2 Wernicke’s Aphasia: Symptoms, Causes, and Treatment
    https://www.healthline.com/health/wernickes-aphasia
    Wernickes aphasia is the loss of the ability to speak and understand language. It occurs when a small area the the left middle side of the brain called the Wernickes area is damaged. […] Wernickes aphasia causes difficulty speaking in coherent sentences or understanding others speech. […] Wernickes aphasia is the most common type of fluent aphasia. It occurs when the left middle side of the brain becomes damaged or altered. This part of the brain is known as Wernickes area, named after Carl Wernicke, a neurologist. Wernickes area of the brain controls human language. […] Lesions or damage in the middle of the left side of the brain causes Wernickes aphasia. […] Stroke is one potential cause of this condition because it impairs blood flow to the brain. If blood does not reach Wernickes area of the brain, it can kill brain cells, resulting in this type of aphasia. Aphasia affects 25 to 40 percent of people who experience strokes. […] Other conditions that may affect this area of the brain include head trauma, tumors, infections, and neurological disorders. […] Its also possible to have aphasia that comes and goes. This may be caused by migraines, seizures, or other medical conditions.
  • #2 Transient Aphasia: Causes of Temporary Aphasia
    https://www.griswoldcare.com/blog/transient-aphasia-causes-of-temporary-aphasia/
    Aphasia can occur anytime the speech center of your brain is obstructed in some way. […] Permanent aphasia is the result of brain damage, while transient aphasia can be caused by any number of fleeting environmental conditions. […] Although most cases of temporary aphasia are the result of migraines, aphasia can be caused by any number of things that create electrical interference in the brain. […] Sometimes called a mini-stroke, TIA describes when blood becomes blocked to a part of the brain for several minutes. […] Suffering from a transient ischemic attack means you’re at much greater risk of stroke, which is the most common preventable cause of permanent aphasia. […] Temporary aphasia can also be caused by an extradural abscess, which is an infection causing pressure on the speech center of the brain. […] Even seizures produce electrical interference, causing temporary aphasia. […] Transient expressive aphasia is a special form of aphasia that can occur when someone travels to a high altitude.
  • #2 Primary progressive aphasia risk factors – Alzheimer’s Research UK
    https://www.alzheimersresearchuk.org/dementia-information/types-of-dementia/primary-progressive-aphasia/risk-factors/
    Primary progressive aphasia (PPA) is caused by damage and loss to brain cells in the front and sides of the brain, called the frontal and temporal lobes. However, the causes for this loss in PPA are not yet clear. […] Most cases of dementia are caused by a mixture of factors including: age, genes, lifestyle, environment. […] In rare cases, semantic dementia or progressive non-fluent aphasia can be caused by a faulty gene that is passed down in families. The main genes involved are called: MAPT, progranulin (or GRN), C9ORF72. […] These genes are also associated with other forms of dementia. […] In these cases there is a strong history of family members being affected at a similar age. These genes are also associated with other forms of frontotemporal dementia.
  • #2 Aphasia – Wikipedia
    https://en.wikipedia.org/wiki/Aphasia
    Substantial damage to tissue anywhere within the region shown in blue (on the figure in the infobox above) can potentially result in aphasia. Aphasia can also sometimes be caused by damage to subcortical structures deep within the left hemisphere, including the thalamus, the internal and external capsules, and the caudate nucleus of the basal ganglia. […] Primary progressive aphasia (PPA), while its name can be misleading, is actually a form of dementia that has some symptoms closely related to several forms of aphasia. It is characterized by a gradual loss in language functioning while other cognitive domains are mostly preserved, such as memory and personality. PPA usually initiates with sudden word-finding difficulties in an individual and progresses to a reduced ability to formulate grammatically correct sentences (syntax) and impaired comprehension. The etiology of PPA is not due to a stroke, traumatic brain injury (TBI), or infectious disease; it is still uncertain what initiates the onset of PPA in those affected by it. […] Epilepsy can also include transient aphasia as a prodromal or episodic symptom. However, the repeated seizure activity within language regions may also lead to chronic, and progressive aphasia.
  • #2 Causes and symptoms of aphasia | Britannica
    https://www.britannica.com/summary/aphasia-pathology
    aphasia, or dysphasia, Defect in the expression and comprehension of words, caused by damage to the frontal and temporal lobes of the brain. It can result from head trauma, tumour, stroke, or infection. […] Symptoms vary with the brain area involved, and the ability to put words in a meaningful order may be lost. […] In some cases, improvement may be due to assumption of some language functions by other areas of the brain.
  • #2 Evaluation of aphasia – Differential diagnosis of symptoms | BMJ Best Practice US
    https://bestpractice.bmj.com/topics/en-us/973
    Aphasia is an acquired impairment of language that affects comprehension and production of words, sentences, and/or discourse. […] It is typically characterized by errors in word retrieval or selection, including: […] An important variable that complicates these deficit associations is the remarkable reorganization of structure-function relationships that often occurs after brain lesions, such that undamaged parts of the brain assume the functions of the damaged part over time, resulting in recovery from even the most severe aphasias (usually only after appropriate language therapy). […] After identifying and treating the underlying cause of aphasia, such as acute stroke or herpes encephalitis, patients may have a residual aphasia. […] Therapy might be augmented with medications, such as memantine or donepezil, or with transcranial direct current stimulation. […] Larger randomized controlled trials are needed to determine whether these interventions have a significant benefit over speech and language therapy alone.
  • #2 Aphasia: Comprehensive Guide to Causes, Symptoms, and Effective Treatments | Medanta
    https://www.medanta.org/patient-education-blog/understanding-aphasia-causes-symptoms-and-treatments
    Aphasia can arise suddenly as a consequence of a stroke or brain injury, or gradually due to progressive brain damage from illnesses or degenerative brain tumors. […] Damage to the left side of the brain, which is often the side that controls language, can result in aphasia and might even be brought on by: Stroke, Head trauma, Brain cancer, Infection, Dementia. […] At this time, it is unclear whether aphasia results in a massive loss of linguistic structure or problems with language access and usage. […] The root of brain damage, the extent of the harm, area of harm, age, and general health might affect the outlook of an aphasia patient. […] If aphasia is brought on by a neurological disease like dementia, you can gradually lose your ability to speak.
  • #2 search-icon
    https://news.christianacare.org/2023/07/frontotemporal-dementia-and-aphasia-what-to-know/
    While communication disorders have a number of neurological causes, the language disorder aphasia can be caused by a specific type of dementia. […] Aphasia is a language disorder caused by damage to the brain from an isolated event, such as a stroke, or a progressive illness, such as frontotemporal dementia. […] When aphasia is caused by frontotemporal dementia or another progressive illness, it is referred to as primary progressive aphasia. […] In some people with frontotemporal dementia, the damage to the brain is more prevalent in the frontal lobe, which controls executive function. […] There is no cure for primary progressive aphasia, but treatment can help people to cope with the loss of language.
  • #2 Aphasia | NIDCD
    https://www.nidcd.nih.gov/health/aphasia
    Aphasia is a disorder that results from damage (usually from a stroke or traumatic brain injury) to areas of the brain that are responsible for language. […] Stroke is the leading cause of aphasia. According to the National Aphasia Association, approximately one third of stroke survivors have aphasia. […] Aphasia can appear suddenly, following brain surgery or after a head injury, or it can develop gradually from the effects of a brain tumor (and associated treatments). Other causes of aphasia include brain infections. […] Different terminology is used to describe progressive causes of aphasia. When people have dementia (e.g., Alzheimers disease, frontotemporal dementia, or other types of dementia) that includes significant cognitive or behavioral changes, they may also develop aphasia as their disease progresses and begins to affect the language areas of the brain. […] PPA can be caused by different types of dementia, such as Alzheimers disease, vascular dementia, Lewy Body dementia, and frontotemporal dementia. Some subtypes of PPA are associated more commonly with particular types of dementia, but there is still much to learn about these relationships.
  • #2 Aphasia – Symptoms & causes – Mayo Clinic
    https://www.mayoclinic.org/diseases-conditions/aphasia/symptoms-causes/syc-20369518
    Aphasia usually happens suddenly after a stroke or a head injury. But it can also come on gradually from a slow-growing brain tumor or a disease that causes progressive, permanent damage (degenerative). The severity of aphasia depends on a number of things, including the cause and the extent of the brain damage. […] The most common cause of aphasia is brain damage resulting from a stroke the blockage or rupture of a blood vessel in the brain. Loss of blood to the brain leads to brain cell death or damage in areas that control language. […] Brain damage caused by a severe head injury, a tumor, an infection or a degenerative process also can cause aphasia. In these cases, the aphasia usually occurs with other types of cognitive problems, such as memory problems or confusion. […] Primary progressive aphasia is the term used for language difficulty that develops gradually. This is due to the gradual degeneration of brain cells located in the language networks. Sometimes this type of aphasia will progress to a more generalized dementia.
  • #2 Aphasia: Prognosis and treatment – UpToDate
    https://www.uptodate.com/contents/aphasia-prognosis-and-treatment
    Aphasia is a loss of ability to produce or understand language. The most common cause of aphasia is cerebrovascular disease, particularly cerebral infarction. Aphasia complicates 15 to 38 percent of ischemic strokes. Other structural pathologies (infection, trauma, neoplasm) and certain neurodegenerative diseases (primary progressive aphasia) can also cause aphasia. […] The prognosis for aphasia recovery depends in large part upon the underlying etiology. This has been best studied in cerebrovascular disease. Most patients with poststroke aphasia improve to some extent.
  • #3 Aphasia – Symptoms & causes – Mayo Clinic
    https://www.mayoclinic.org/diseases-conditions/aphasia/symptoms-causes/syc-20369518
    Aphasia usually happens suddenly after a stroke or a head injury. But it can also come on gradually from a slow-growing brain tumor or a disease that causes progressive, permanent damage (degenerative). The severity of aphasia depends on a number of things, including the cause and the extent of the brain damage. […] The most common cause of aphasia is brain damage resulting from a stroke the blockage or rupture of a blood vessel in the brain. Loss of blood to the brain leads to brain cell death or damage in areas that control language. […] Brain damage caused by a severe head injury, a tumor, an infection or a degenerative process also can cause aphasia. In these cases, the aphasia usually occurs with other types of cognitive problems, such as memory problems or confusion. […] Primary progressive aphasia is the term used for language difficulty that develops gradually. This is due to the gradual degeneration of brain cells located in the language networks. Sometimes this type of aphasia will progress to a more generalized dementia.
  • #3 Aphasia Symptoms, Causes & Treatment | Baptist Health
    https://www.baptisthealth.com/care-services/conditions-treatments/aphasia
    Aphasia results from damage to the brains centers of communication. This damage can occur abruptly, by means of a stroke or head injury, or more gradually, by means of a tumor or a degenerative disease, such as dementia. Stroke is the most common cause. The National Aphasia Association estimates that between one-quarter to four-tenths of all stroke survivors develop a form of aphasia. […] Risk factors for aphasia vary by individual and also depend on unforeseen circumstances, such as the likelihood of a serious accident. However, steps taken to avoid a stroke, including healthy diet, regular exercise, adequate sleep, stress control, and tobacco cessation, also reduce the possibility of stroke-related aphasia.