Materiały źródłowe

• #1 Basal Cell Carcinoma Treatment

  https://www.skincancer.org/skin-cancer-information/basal-cell-carcinoma/bcc-treatment-options/

  When detected early, most basal cell carcinomas (BCCs) can be treated and cured. Prompt treatment is vital, because as the tumor grows, it becomes more dangerous and potentially disfiguring, requiring more extensive treatment. Certain rare, aggressive forms can be fatal if not treated promptly. […] If you’ve been diagnosed with a small or early BCC, a number of effective treatments can usually be performed on an outpatient basis, using a local anesthetic with minimal pain. Afterwards, most wounds can heal naturally, leaving minimal scarring. […] Options include: Curettage and electrodesiccation (electrosurgery), Mohs surgery, Excisional surgery, Radiation therapy, Photodynamic therapy, Cryosurgery, Laser surgery, Topical medications, Medications for advanced BCC. […] Mohs surgery is the gold standard, the most effective technique for removing BCCs, harming minimal healthy tissue while achieving the highest possible cure rate — up to 99 percent on tumors treated for the first time.

• #1 Basal cell carcinoma – Diagnosis & treatment – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/basal-cell-carcinoma/diagnosis-treatment/drc-20354193

  The goal of treatment for basal cell carcinoma is to remove the cancer completely. Which treatment is best for you depends on the type, location and size of your cancer, as well as your preferences and ability to do follow-up visits. Treatment selection can also depend on whether this is a first-time or a recurring basal cell carcinoma. […] Basal cell carcinoma is most often treated with surgery to remove all of the cancer and some of the healthy tissue around it. […] Options might include: […] Surgical excision. In this procedure, your doctor cuts out the cancerous lesion and a surrounding margin of healthy skin. The margin is examined under a microscope to be sure there are no cancer cells. […] Mohs surgery. During Mohs surgery, your doctor removes the cancer layer by layer, examining each layer under the microscope until no abnormal cells remain. This allows the surgeon to be certain the entire growth is removed and avoid taking an excessive amount of surrounding healthy skin.

• #1 Basal Cell Carcinoma Treatment

  https://www.skincancer.org/skin-cancer-information/basal-cell-carcinoma/bcc-treatment-options/

  For small, early BCCs that have not spread, excisional surgery is frequently the only treatment required. Cure rates are above 95 percent in most body areas, similar to those of curettage and electrodesiccation. […] With radiation therapy, there is no way of knowing that all of the tumor was destroyed. […] Cryosurgery is effective for smaller, superficial BCCs. […] Laser surgery is not yet FDA-approved for superficial BCCs but is sometimes used as a secondary therapy, especially when other techniques have been unsuccessful. […] PDT can be used for some superficial BCCs on the face and scalp but is not recommended for invasive BCC. […] 5-FU, a chemotherapy approved to treat certain internal cancers, has also been FDA-approved in topical form for superficial BCCs, with cure rates between 80 and 90 percent.

• #1 Basal Cell and Cutaneous Squamous Cell Carcinomas: Diagnosis and Treatment | AAFP

  https://www.aafp.org/pubs/afp/issues/2020/0915/p339.html

  Treatment of BCC with Mohs micrographic surgery has the lowest recurrence rate. However, because of cost and limited availability, it is best considered for larger tumors (i.e., greater than 2 cm on the trunk or extremities), more invasive histologic subtypes (i.e., micronodular, infiltrative, and morpheaform), or tumors at sites with a higher risk of recurrence. The recurrence rate for tumors treated with Mohs surgery is 4.4% at 10 years, whereas standard surgical excision has a 12.2% recurrence rate at 10 years. BCC and CSCC are characterized by asymmetric subclinical extension of the tumor beyond the clinically visible lesion. National Cancer Care Network guidelines recommend the excision of low-risk primary BCC with a 4-mm margin of uninvolved skin around the tumor. Incomplete excision of the primary tumor (i.e., pathology demonstrating tumor at the surgical margin) should be followed by immediate reexcision or Mohs micrographic surgery because it is difficult to control recurrent BCC. Electrodesiccation and curettage is an appropriate choice for low-risk primary, nonfibrosing tumors. Tumor recurrence rates at five years range from less than 2% to more than 20%, depending on lesion characteristics and practitioner skill. Consider cryotherapy for low-risk BCC when more effective therapies are contraindicated or impractical. Biopsy should be performed before the procedure to determine tumor depth because cryotherapy is not indicated for tumors that are more than 3-mm deep. Reported recurrence rates for cryosurgery range from less than 2% to up to 20%, depending on lesion characteristics and duration of follow-up. If surgical excision of BCC is not feasible, contraindicated, or not preferred by the patient, radiotherapy is an additional treatment option. Radiotherapy requires multiple sessions, and postradiation changes can include dyspigmentation and radiodystrophy. Tumor recurrence postradiation may be more difficult to treat. Topical imiquimod (Aldara), an immunomodulator, is approved by the U.S. Food and Drug Administration (FDA) for treatment of superficial BCC, but not for other BCC subtypes. Rates of clinical and histologic cure at one year range from 60% to 80%. Monotherapy with topical fluorouracil, an antimetabolite, is also FDA-approved for the treatment of superficial BCC. These treatments are optimal for patients with small tumors in low-risk locations who are unable to tolerate more definitive therapies.

• #1 Basal Cell Carcinoma: Symptoms, Causes, and Treatment — DermNet

  https://dermnetnz.org/topics/basal-cell-carcinoma

  What is the treatment for primary basal cell carcinoma? The treatment for a BCC depends on its type, size and location, the number to be treated, patient factors, and the preference or expertise of the doctor. Most BCCs are treated surgically. Long-term follow-up is recommended to check for new lesions and recurrence; the latter may be unnecessary if histology has reported wide clear margins. […] Excision means the lesion is cut out and the skin stitched up. Most appropriate treatment for nodular, infiltrative and morphoeic BCCs. Should include 3 to 5 mm margin of normal skin around the tumour. Very large lesions may require flap or skin graft to repair the defect. Pathologist will report deep and lateral margins. Further surgery is recommended for lesions that are incompletely excised. […] Mohs micrographically controlled surgery involves examining carefully marked excised tissue under the microscope, layer by layer, to ensure complete excision. Very high cure rates achieved by trained Mohs surgeons. Used in high-risk areas of the face around eyes, lips and nose. Suitable for ill-defined, morphoeic, infiltrative and recurrent subtypes. Large defects are repaired by flap or skin graft.

• #1 Basal Cell Carcinoma: What it is, Symptoms & Treatment

  https://my.clevelandclinic.org/health/diseases/4581-basal-cell-carcinoma

  Basal cell carcinoma is a type of skin cancer that causes a lump, bump or lesion to form on the outside layer of your skin (epidermis). Treatment to remove cancer from your skin leads to a positive outlook. […] Your provider will treat basal cell carcinoma by removing cancer from your body. To remove cancer, your treatment options could include: Electrodessication and curettage: Scraping off the cancerous lump with a curette and then burning with a special electric needle. Surgery: Removing the cancerous lump or lesion with a scalpel (excision or Mohs surgery). Cryotherapy or cryosurgery: Freezing the cancerous lump to remove it. Chemotherapy: Using powerful medicines to kill cancerous cells in your body. Photodynamic therapy (PDT): Applying blue light and a light-sensitive agent to your skin. Laser therapy: Using lasers (high-energy beams) to remove cancer instead of using a scalpel.

• #1 Basal Cell Carcinoma: Symptoms, Causes, and Treatment — DermNet

  https://dermnetnz.org/topics/basal-cell-carcinoma

  Superficial skin surgery comprises shave, curettage, and electrocautery. It is a rapid technique using local anaesthesia and does not require sutures. Suitable for small, well-defined nodular or superficial BCCs. Lesions are usually located on trunk or limbs. Wound is left open to heal by secondary intention. Moist wound dressings lead to healing within a few weeks. Eventual scar quality variable. […] Cryotherapy is the treatment of a superficial skin lesion by freezing it, usually with liquid nitrogen. Suitable for small superficial BCCs on covered areas of trunk and limbs. Best avoided for BCCs on head and neck, and distal to knees. Double freeze-thaw technique. Results in a blister that crusts over and heals within several weeks. Leaves permanent white mark. […] Photodynamic therapy (PDT) refers to a technique in which BCC is treated with a photosensitising chemical, and exposed to light several hours later. Topical photosensitisers include aminolevulinic acid lotion and methyl aminolevulinate cream. Suitable for low-risk small, superficial BCCs. Best avoided if tumour in site at high risk of recurrence. Results in inflammatory reaction, maximal 34 days after procedure. Treatment repeated 7 days after initial treatment. Excellent cosmetic results.

• #1 Basal Cell Carcinoma – StatPearls – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK482439/

  Treatment of BCC is usually surgical, but some forms of BCC are amenable to medical treatment or radiation therapy. The various types of therapy include Mohs micrographic surgery (MMS), standard surgical excision, EDC, radiation, photodynamic therapy, cryosurgery, topical therapies, and systemic medications such as Vismodegib. […] Mohs surgery provides the best long-term cure rate of any treatment modality for BCC. […] Postoperative pathologic analysis with permanent sections follows standard surgical excision. […] EDC is frequently used to treat low-risk BCCs. […] Radiation therapy is a primary option for treating BCC or SCC if surgery is contraindicated. […] Cryosurgery is another treatment option for low-risk BCCs. […] Topical therapy is another treatment for basal cell carcinoma.

• #1 Basal cell carcinoma – Diagnosis & treatment – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/basal-cell-carcinoma/diagnosis-treatment/drc-20354193

  Sometimes other treatments might be recommended in certain situations, such as if you’re unable to undergo surgery or if you don’t want to have surgery. […] Other treatments include: […] Curettage and electrodessication (C and E). C and E treatment involves removing the surface of the skin cancer with a scraping instrument (curet) and then searing the base of the cancer with an electric needle. […] Radiation therapy. Radiation therapy uses high-energy beams, such as X-rays and protons, to kill cancer cells. […] Freezing. This treatment involves freezing cancer cells with liquid nitrogen (cryosurgery). It may be an option for treating superficial skin lesions. […] Topical treatments. Prescription creams or ointments might be considered for treating small and thin basal cell carcinomas when surgery isn’t an option.

• #1 Treatments for basal cell carcinoma | Canadian Cancer Society

  https://cancer.ca/en/cancer-information/cancer-types/skin-non-melanoma/treatment/basal-cell-carcinoma

  Cryosurgery uses extreme cold to freeze and destroy tissue. It is mainly used to treat low-risk BCC on the trunk of the body, arms or legs. […] A skin graft or a skin flap may be done to repair the skin and nearby area after BCC is removed. Skin from another area of the body is removed and placed over the surgical area to cover the open wound and repair the skin. It may be done if a large area of skin is removed to make sure the cancer is completely gone. […] Radiation therapy uses high-energy rays or particles to destroy cancer cells. It is used instead of surgery when the cancer is in an area that is hard to treat, such as an eyelid or ear. […] Drug therapy uses drugs to treat BCC. The type of drug therapy used depends on where the cancer is located. […] Topical therapy is given as a cream, or ointment that contains a drug and is applied on the skin. It may be used to treat small, superficial or low-risk BCC on the neck, trunk of the body, arms or legs.

• #1 Treatment for non-melanoma skin cancer – NHS

  https://www.nhs.uk/conditions/non-melanoma-skin-cancer/treatment/

  Non-melanoma skin cancer can usually be effectively treated. […] Surgery is the main treatment for non-melanoma skin cancer. Radiotherapy, targeted medicines, photodynamic therapy and chemotherapy are also sometimes used. […] Surgery is the main treatment for non-melanoma skin cancer, especially if it’s found early. […] Several types of surgery can be used to treat non-melanoma skin cancer, including: cutting out the cancer and some surrounding healthy skin (excisional biopsy) and freezing the affected skin, which forms a scab that drops off a few weeks later (cryosurgery). […] Radiotherapy uses high-energy rays of radiation to kill cancer cells. […] Sometimes radiotherapy is used after surgery to help reduce the chance of the cancer coming back. […] Targeted medicines aim to stop the cancer growing.

• #1 Basal Cell Carcinoma Treatment & Management: Approach Considerations, Surgical Modalities and Guidelines, Topical Treatments

  https://emedicine.medscape.com/article/276624-treatment

  The efficacy of PDT is low, and this treatment is frequently palliative. […] Vismodegib (Erivedge) is the first FDA-approved drug for advanced forms of BCC. […] A second hedgehog pathway inhibitor (HHI), sonidegib (Odomzo), was approved by the FDA in 2015. […] Cemiplimab, a programmed death 1 (PD-1) inhibitor, was the first immunotherapy approved by the FDA for advanced BCC after hedgehog pathway inhibition. […] The following is a list of treatments and their 5-year recurrence rates for primary BCCs: Surgical excision – 10.1%, Radiation therapy – 8.7%, Curettage and electrodesiccation – 7.7%, Cryotherapy – 7.5%, All non-Mohs modalities – 8.7%, Mohs micrographic surgery – 1.0%. […] The NCCN guideline supports RT for patients whose condition is appropriate, with the reservation that in order to achieve its benefits (high cure rates and good comesis), it must be administered carefully and with attention to algorithm details by well-trained specialists.

• #1 Basal cell carcinoma – Diagnosis & treatment – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/basal-cell-carcinoma/diagnosis-treatment/drc-20354193

  Photodynamic therapy. Photodynamic therapy combines photosensitizing drugs and light to treat superficial skin cancers. […] Very rarely, basal cell carcinoma may spread (metastasize) to nearby lymph nodes and other areas of the body. Additional treatment options in this situation include: […] Targeted drug therapy. Targeted drug treatments focus on specific weaknesses present within cancer cells. […] Chemotherapy. Chemotherapy uses powerful drugs to kill cancer cells. It might be an option when other treatments haven’t helped.

• #1 Basal Cell Carcinoma Treatment & Management: Approach Considerations, Surgical Modalities and Guidelines, Topical Treatments

  https://emedicine.medscape.com/article/276624-treatment

  Topical 5% imiquimod is approved by the US Food and Drug Administration (FDA) for the treatment of nonfacial superficial BCCs that are less than 2 cm in diameter. Lesions are generally treated once daily, 5 days per week, for a duration of 6-12 weeks. […] Likewise, topical fluorouracil 5% is approved by the FDA for the treatment of superficial BCC, administered twice daily for 3-6 weeks. […] For tumors that are more difficult to treat (ie, infiltrative BCC, morpheaform [sclerosing] BCC, micronodular BCC, and recurrent BCC) or those in which sparing normal (noncancerous) tissue is paramount, Mohs micrographic surgery should be considered and discussed with the patient. […] Radiation therapy is a primary treatment option in patients who are not surgical candidates. […] A Hedgehog pathway inhibitor (HHI) can be used to treat patients with locally advanced BCC who are not candidates for surgery or radiation therapy, or whose disease has recurred after surgery or radiation therapy, and those with metastatic BCC.

• #1 Basal Cell and Squamous Cell Carcinoma | Conditions | UCSF Health

  https://www.ucsfhealth.org/conditions/basal-cell-and-squamous-cell-carcinoma

  UCSF provides superior, proven care to prevent, detect and manage basal cell and squamous cell carcinomas, and will tailor cutting-edge treatment plans to the individual patient. […] Numerous treatment options are available for basal cell and squamous cell carcinoma. Your therapy will depend upon the type of skin cancer you have and its stage. […] Surgery. Many skin cancers can be cut from the skin quickly and easily. In fact, the cancer is sometimes completely removed at the time of the biopsy, and no further treatment is needed. […] Curettage and Electrodesiccation. Doctors commonly use a type of surgery called curettage. After a local anesthetic numbs the area, the cancer is scooped out with a curette, an instrument with a sharp, spoon-shaped end. The area is also treated by electrodesiccation. An electric current from a special machine is used to control bleeding and kill any cancer cells remaining around the edge of the wound. Most patients develop a flat, white scar.

• #1 Skin Cancer Treatment – NCI

  https://www.cancer.gov/types/skin/patient/skin-treatment-pdq

  Treatment of basal cell carcinoma that is localized may include the following: […] Simple excision. […] Mohs micrographic surgery. […] Radiation therapy. […] Curettage and electrodesiccation. […] Cryosurgery. […] Photodynamic therapy. […] Topical chemotherapy. […] Topical immunotherapy (imiquimod). […] Laser surgery (rarely used). […] Treatment of basal cell carcinoma that is metastatic or cannot be treated with local therapy may include the following: […] Targeted therapy with a signal transduction inhibitor (vismodegib or sonidegib). […] A clinical trial of a new treatment. […] Treatment of recurrent basal cell carcinoma that is not metastatic may include the following: […] Simple excision. […] Mohs micrographic surgery. […] There are different types of treatment for patients with basal cell carcinoma, squamous cell carcinoma of the skin, and actinic keratosis.

• #1 Basal Cell Carcinoma: Symptoms, Causes, and Treatment — DermNet

  https://dermnetnz.org/topics/basal-cell-carcinoma

  What is the treatment for advanced or metastatic basal cell carcinoma? Locally advanced primary, recurrent or metastatic BCC requires multidisciplinary consultation. Often a combination of treatments is used. Surgery, Radiotherapy, Targeted therapy. Targeted therapy refers to the hedgehog signalling pathway inhibitors, vismodegib and sonidegib. These drugs have some important risks and side effects.

• #1 Basal Cell Carcinoma Treatment

  https://www.skincancer.org/skin-cancer-information/basal-cell-carcinoma/bcc-treatment-options/

  Vismodegib is used for the extraordinarily rare cases of metastatic BCC or locally advanced BCC (tumors that have penetrated the skin deeply or frequently recurred) that either recur after surgery or radiation, or cannot be treated with surgery or radiation and have become dangerous or life-threatening. […] Cemiplimab is used to treat patients with advanced basal cell carcinoma (BCC) previously treated with a hedgehog pathway inhibitor (HHI) or for whom an HHI is not appropriate.

• #1 Basal Cell Carcinoma Treatment & Management: Approach Considerations, Surgical Modalities and Guidelines, Topical Treatments

  https://emedicine.medscape.com/article/276624-treatment

  In 2021, the first immunotherapy, cemiplimab (Libtayo), was fully approved for locally advanced BCC and granted accelerated approval for patients with metastatic BCC previously treated with an HHI or for whom an HHI is not appropriate. […] The goal of therapy for patients with BCC is removal of the tumor with the best possible cosmetic result. By far, surgical modalities are the most studied, most effective, and most used BCC treatments. […] National Comprehensive Cancer Network (NCCN) guidelines recommend treating low-risk BCC in nonhair-bearing areas with curettage and electrodessication. […] If fat is reached, surgical excision should generally be performed. […] Standard excision is an alternative, if the lesion can be excised with 4-mm clinical margins and second-intention healing, linear repair, or skin graft.

• #1 Skin Cancer Treatment – NCI

  https://www.cancer.gov/types/skin/patient/skin-treatment-pdq

  The following types of treatment are used: […] Surgery […] Radiation therapy […] Chemotherapy […] Photodynamic therapy […] Immunotherapy […] Targeted therapy […] Chemical peel […] Other drug therapy. […] Simple excision, Mohs micrographic surgery, curettage and electrodesiccation, and cryosurgery are used to treat basal cell carcinoma and squamous cell carcinoma of the skin. […] Topical fluorouracil (5-FU) is used to treat basal cell carcinoma. […] Photodynamic therapy is also used to treat actinic keratoses. […] Topical imiquimod therapy is an immune response modifier that may be used to treat some basal cell carcinomas and is applied to the skin as a cream. […] Signal transduction inhibitor therapy: This treatment block signals that are passed from one molecule to another inside a cell. […] Vismodegib and sonidegib are signal transduction inhibitors used to treat basal cell carcinoma.

• #1 Basal cell carcinoma

  https://www.aad.org/member/clinical-quality/guidelines/bcc

  Stratification of BCC in accordance with the National Comprehensive Cancer Network Guidelines is recommended, with the goal of providing the most clinically relevant stratification to guide management of BCC. […] Optimal biopsy techniques are considered, with the aim of obtaining a biopsy permitting accurate diagnosis and management of BCC. […] Surgical treatment modalities are reviewed, as surgery remains the cornerstone of BCC treatment. […] Nonsurgical approaches (topicals, radiation therapy, photodynamic therapy) have lower cure rates than surgical treatment and should only be considered for low-risk BCC or if surgery is contraindicated. […] As there are limited treatment options for metastatic disease, early and complete treatment is important. […] Patients diagnosed with BCC should have annual checks for recurrence or other new primary skin cancer(s).

• #1 Treated for Basal Cell Carcinoma? Here Is What to Expect During Recovery

  https://www.miamidermcenter.com/2024/08/23/treated-for-basal-cell-carcinoma-here-is-what-to-expect-during-recovery/

  Basal cell carcinoma is the most prevalent skin cancer. While it can be a scary diagnosis, it is treatable. […] Mohs surgery is a unique treatment for basal cell skin cancer. […] After Mohs surgery, it is essential to rest. […] Your doctor will give you specific instructions on how to care for your wound. […] ED & C is a basal cell carcinoma treatment where the doctor scrapes off the cancerous skin cells with a special tool. […] Surgical excision involves cutting out the skin cancer along with some surrounding healthy skin. […] It is important to know when you need to see your skin cancer surgeon during recovery after basal cell carcinoma treatment. […] Always keep your scheduled follow-up appointments. […] The Dermatology and Skin Cancer Center provides a variety of dermatologic services, such as skin cancer screenings, prevention, and treatments. Our clinic specializes in providing Mohs micrographic surgery for treating high-risk skin cancers, such as basal cell carcinoma.

• #1 Skin cancer types: Basal cell carcinoma diagnosis and treatment

  https://www.aad.org/public/diseases/skin-cancer/types/common/bcc/treatment

  Two such medications have been approved by the U.S. Food and Drug Administration (FDA). […] Cemplimab is a type of medication called immunotherapy. […] Newer treatments for deep basal cell skin cancers and ones that have spread are being studied in clinical trials. […] When found early and treated, this skin cancer can often be removed. However, this skin cancer can return.

• #1 Azthena logo with the word Azthena

  https://www.news-medical.net/news/20250127/New-therapy-shows-promise-in-treating-basal-cell-carcinoma.aspx

  Basal cell carcinomas, the most common form of skin cancer, occur in chronically sun-exposed areas such as the face. […] A research team from MedUni Vienna and University Hospital Vienna has now investigated the effectiveness of a new type of therapy and achieved promising results: The active substance TVEC led to a reduction in the size of the basal cell carcinoma in all study participants, which not only improved surgical removal, but also led to a complete regression of the tumor in some of the patients. […] In the study Talimogene Laherparepvec (TVEC) was used, which has so far only been approved for the treatment of superficial melanoma metastases. […] The aim of the study was to reduce the size of the tumor before a planned operation so that patients would not suffer any functional or cosmetic restrictions after the procedure.

• #1 Therapeutic Approaches for Advanced Basal Cell Carcinoma: A Comprehensive Review

  https://www.mdpi.com/2072-6694/17/1/68

  Over the last decade, novel therapeutic approaches for patients with laBCC and mBCC not suitable for surgery or radiotherapy have emerged. While earlier treatment regimens mainly involved platinum-based cytotoxic chemotherapy, targeted strategies such as hedgehog inhibitor and immunotherapy, meanwhile, proved to be superior, in terms of both treatment response and tolerability. […] The SMO inhibitor vismodegib (Erivedge) was the first hedgehog pathway inhibitor approved for advanced BCC by the FDA and EMA in 2012 and 2013, respectively, and is indicated for patients with laBCC and mBCC not eligible for surgery or radiotherapy. […] Sonidegib (Odomzo) is the second hedgehog inhibitor available for patients with laBCC unsuitable for surgery or radiotherapy, and received regulatory approval in 2015 based on the results of the BOLT trial.

• #1 New Directions in the Treatment of Basal Cell Carcinoma

  https://www.dermatologytimes.com/view/new-directions-in-the-treatment-of-basal-cell-carcinoma

  In the treatment of basal cell carcinoma (BCC), The name of the game is identifying the lesions early on and then treating them accordingly, right? […] Ibrahim then mentions an alternative BCC treatmentone thats seen an increased use in dermatologyimmune checkpoint inhibitors. Immune checkpoint inhibitors block checkpoint proteins from binding with their partner proteins. This prevents the off signal from being communicated so that the bodys T cells can kill cancer cells. For patients who are unable to tolerate the AEs of Hedgehog inhibitors, cemiplimab-rwlc (Libtayo), a PD-1 immune checkpoint inhibitor, offers hope for an alternative and more tolerable treatment. […] Immune checkpoint inhibitors are game changers. They really are the holy grail to oncology, Patel said. […] Patel and Ibrahim agreed that immune checkpoint inhibitors will change the way dermatologists treat BCC. For example, in patients who have a suppressed immune system or have received organ transplants, cancer can wreak havoc on their bodies. Now with immune checkpoint inhibitors like cemiplimab, more options are available for these patients who would, oftentimes, be debilitated by cancer. Immune checkpoint inhibitors will put control back in the hands of dermatologists to effectively and safely treat BCC.

• #2 Treatments for basal cell carcinoma | Canadian Cancer Society

  https://cancer.ca/en/cancer-information/cancer-types/skin-non-melanoma/treatment/basal-cell-carcinoma

  The following are treatment options for basal cell carcinoma (BCC) of the skin. Your healthcare team will suggest treatments based on the risk group. They will work with you to develop a treatment plan. […] BCC is most often treated with local therapy. This means that only the cancer on the skin and the area around it are treated. Surgery is the main local therapy used for BCC. […] If BCC has spread to other parts of the body, systemic therapy may be used. Systemic therapy travels through the bloodstream to reach and destroy cancer cells all over the body. Targeted therapy and immunotherapy are some systemic therapies that may be used for BCC. […] Surgery is usually offered for BCC. The type of surgery done depends on the risk group, where the cancer is located and the size of the cancer.

• #2 Treatment of Facial Basal Cell Carcinoma: A Review

  https://pmc.ncbi.nlm.nih.gov/articles/PMC3135095/

  Basal cell carcinomas (BCCs) are locally destructive malignancies of the skin. They are the most common type of cancer in the western world. […] A good understanding of the options available is important. Management decisions may be influenced by various factors including the patient’s age and comorbidities and the lesion subtype and location. […] Although traditionally standard excision has been the treatment of choice various other options are available including: Mohs micrographic surgery, curettage and cautery, cryosurgery, radiotherapy, topical imiquimod, photodynamic therapy and topical 5-fluorouracil. […] Standard surgical excision is a highly effective treatment for primary BCC and historically has been the mostly common treatment option. […] Generally standard surgical excision is considered a good treatment option for all BCCs arising on the face with 5-year recurrence rates of anything up to 10% providing adequate margins are taken.

• #2 Basal Cell Carcinoma – StatPearls – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK482439/

  Basal cell carcinoma is the most common cutaneous malignancy, affecting close to one in five Americans. […] This activity describes the risk factors, evaluation, and management of basal cell carcinoma and highlights the role of the interprofessional team in enhancing care delivery for affected patients. […] Summarize the treatment strategies for basal cell carcinoma. […] The current mainstay of BCC treatment involves surgical modalities such as excision, electrodesiccation and curettage (EDC), cryosurgery, and Mohs micrographic surgery. Such methods are typically reserved for localized BCC and offer high 5-year cure rates, generally over 95%. […] Therapy selection depends on the patient’s age and gender as well as the site, size, and type of lesion. No single treatment method is ideal for all lesions or all patients. A biopsy should be performed in all patients with suspected BCC to confirm the diagnosis and determine the histologic subtype. The main goals of BCC treatment are (1) to completely remove the tumor to prevent recurrence at a later date, (2) to correct any functional impairment resulting from the tumor, and (3) to give the best cosmetic result to the patient, especially because most BCCs are on the face.

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