Materiały źródłowe

• #1 Pineoblastoma – Symptoms, Diagnosis, and TreatmentSecond Opinion IconGroup 9Second Opinion IconGroup 9Group 49

  https://www.barrowneuro.org/condition/pineoblastoma/

  Pineoblastoma Symptoms depend on the tumor’s size, spread, and impact on crucial structures surrounding the lesion. Because the pineal gland is near areas that control vision, eye movement, and the flow of cerebrospinal fluid (CSF) flow, symptoms often impair these structures. […] If you or someone you know have a pineoblastoma, you may experience one or more of the following symptoms: […] Headaches: A pineoblastoma often causes increased pressure inside the skull, leading to persistent headaches that worsen over time and are more severe in the morning or when lying down. […] Nausea and vomiting: Due to the same intracranial pressure, nausea and vomiting are common and can be more acute in the mornings. […] Hydrocephalus: Pineoblastomas can also block the flow of cerebrospinal fluid (CSF) and cause hydrocephalus, or a fluid buildup in the brain, which leads to vomiting and lethargy.

• #2 Pineoblastoma Overview | Expert Surgeon | Aaron Cohen-Gadol, MD | Aaron Cohen-Gadol, MD

  https://www.aaroncohen-gadol.com/en/patients/pineoblastoma/types/overview

  Pineoblastoma Symptoms […] The symptoms of pineoblastoma are generally related to its location in the brain and the way it affects surrounding structures. Because the pineal gland is positioned near the fluid pathways of the brain, symptoms often result from the tumor obstructing the flow of CSF, leading to increased pressure in the brain. Common symptoms of pineoblastoma include: […] Persistent headaches, which may worsen in the morning or when lying down […] Nausea and vomiting, especially in the morning […] Difficulty with eye movements, double vision, or blurred vision […] Problems with balance and coordination, such as unsteadiness while walking […] Fatigue and weakness, leading to general lethargy […] Sleep disturbances, including difficulty sleeping or excessive sleepiness.

• #3 Pineoblastoma: Causes, Symptoms, Treatment & Prognosis

  https://my.clevelandclinic.org/health/diseases/24950-pineoblastoma

  Symptoms of pineoblastoma include: A headache. Fatigue. Difficulty moving your eyes. Problems with balance and coordination. Changes to your behavior. Nausea. […] The symptoms of pineoblastoma occur due to hydrocephalus, or a buildup of cerebrospinal fluid around your brain. The cancer spreads through cerebrospinal fluid to other parts of your brain and central nervous system (CNS). Pineoblastoma rarely spreads beyond your CNS. […] While there isn’t a cure available for pineoblastoma, there are several treatment options. Your healthcare provider can surgically remove the tumor if it hasn’t spread. Pineoblastoma can be challenging to treat, which increases the risk of complications from this type of cancer. It may lead to symptoms that get worse over time and cause a shortened life expectancy. There’s a chance that it may come back after treatment.

• #4 Pineoblastoma in Children and Teens – Together by St. Jude™

  https://together.stjude.org/en-us/conditions/cancers/pineoblastoma.html

  Signs and symptoms of pineoblastoma depend on the tumor size and if it has spread to other parts of the brain. Often, the growing tumor causes cerebrospinal fluid to build up in the brain, adding pressure. This is known as hydrocephalus. The increased pressure may cause some symptoms that occur with pineal tumors. […] Pineoblastoma symptoms may include: Eye pupils that are larger than normal or are differing sizes, Changes in eye movements, especially problems looking up, Headache, Dehydration, Thirsty more than normal, Bed-wetting that starts suddenly, Frequent urination (peeing) at night, Nausea and vomiting, Changes in energy level, Tiredness, Problems with coordination, balance, or movement, Weakness on 1 side of the body, Seizures, Changes in behavior, Slow rate of growth. […] The prognosis for pineoblastoma depends on many factors. The 5-year survival rate for childhood pineoblastoma ranges from 6785% in the United States, depending on the type, your child’s age, and the treatments received. […] Successful removal of the tumor and treatment with radiation therapy are linked to better outcomes for children with pineoblastoma.

• #5 SSA – POMS: DI 23022.273 – Pineoblastoma – Childhood – 08/09/2023

  https://secure.ssa.gov/apps10/poms.nsf/lnx/0423022273

  Pineoblastoma is an aggressive cancerous (malignant) tumor that grows in a part of the brain known as the pineal gland. It occurs mainly in children. These tumors are primary central nervous system tumors that start in the brain and can spread to the spinal cord and beyond. […] Pineoblastomas fast growth usually causes cerebrospinal fluid (CSF) to build up in and around the brain (hydrocephalus), increasing intracranial pressure. […] Some general symptoms are: Headaches; Nausea; Vomiting; Difficulty with eye movements (nystagmus); Difficulty with balance; and Difficulty walking. […] The relative five-year survival rate for children is 50-60%. Many factors can affect prognosis, including tumor grade and type, traits of the cancer, the persons age and health when diagnosed, and response to treatment. […] Patients who receive radiation therapy are at risk for long-term endocrine system changes that may lead to problems such as delayed growth, fatigue, and fertility problems. Problems with hydrocephalus can persist in patients who have been successfully treated.

• #6 Pineoblastoma Symptoms | Expert Surgeon | Aaron Cohen-Gadol, MD | Aaron Cohen-Gadol, MD

  https://www.aaroncohen-gadol.com/en/patients/pineoblastoma/types/symptoms

  Pineoblastoma is a rare and aggressive type of brain tumor that starts in the pineal gland, a tiny gland located deep in the brain that helps regulate sleep by producing a hormone called melatonin. Though uncommon, pineoblastoma primarily affects children and can grow rapidly, leading to a variety of challenging symptoms. […] The symptoms of pineoblastoma can vary widely based on the tumor’s size, location, and growth rate. Because the pineal gland is close to areas of the brain that control vision, movement, and other vital functions, a tumor in this region can lead to a range of challenging symptoms. Some common signs of pineoblastoma include: […] Persistent and worsening headaches are a frequent symptom, often caused by increased intracranial pressure as the tumor grows and obstructs normal fluid flow in the brain.

• #7 Pineoblastoma Symptoms | Expert Surgeon | Aaron Cohen-Gadol, MD | Aaron Cohen-Gadol, MD

  https://www.aaroncohen-gadol.com/en/patients/pineoblastoma/types/symptoms

  The increased pressure can lead to nausea and vomiting, particularly in the morning. These symptoms are typically more pronounced when lying down. […] Pineoblastoma can press on parts of the brain involved in vision, leading to blurred or double vision, difficulty focusing, or trouble moving the eyes. […] Tumors near the brainstem or cerebellum may cause difficulties with walking, balance, and coordination. […] Because the pineal gland regulates sleep by making melatonin, pineoblastomas can disrupt sleep patterns, causing excessive drowsiness or trouble sleeping. […] Patients may experience changes in mood, behavior, or personality, as well as difficulties with memory, focus, or speech. […] These symptoms may develop slowly over time or appear suddenly, and they can be mistaken for other conditions, which can delay diagnosis. If these symptoms continue or worsen, it is essential to seek medical evaluation as early detection can make a difference in patient outcomes.

• #8 Mayo Clinic Health Library – Pineoblastoma | Swiss Medical Network

  https://www.swissmedical.net/en/healtcare-library/con-20310674

  Pineoblastoma may cause headaches, sleepiness and changes in the way the eyes move. […] Pineoblastoma signs and symptoms include: Behavior changes. Headaches. Lack of energy. Nausea. Problems with memory and thinking. […] Pineoblastoma sometimes causes eye symptoms. This can happen when the cancer causes pressure on parts of the brain that help with vision. The eye symptoms that pineoblastoma causes are sometimes called Parinaud syndrome. Eye symptoms caused by pineoblastoma include: Blurred vision. Double vision. Problems focusing on objects that are up close. Problems looking upward.

• #9 Pineoblastoma – Symptoms, Diagnosis, and TreatmentSecond Opinion IconGroup 9Second Opinion IconGroup 9Group 49

  https://www.barrowneuro.org/condition/pineoblastoma/

  Fatigue: Fatigue or changes in energy levels are common symptoms of brain tumors. This is due to the body’s response to the tumor and the energy needed to cope with the symptoms. As a pineoblastoma progresses, it’s common to feel increasingly tired or weak. […] If you or a loved one is experiencing any of these symptoms, it’s essential to consult a trusted healthcare professional. While these symptoms overlap with other neurological conditions, an early diagnosis can lead to better outcomes.

• #10 Pineoblastoma | About the Disease | GARD

  https://rarediseases.info.nih.gov/diseases/9369/pineoblastoma

  Pineoblastoma is a type of cancerous (malignant) tumor that grows in a part of the brain known as the pineal gland. It occurs mainly in children. Symptoms of Pineoblastoma include a buildup of fluid around the brain (hydrocephalus), headaches, nausea, and difficulty with eye movement. […] Symptoms of this disease may start to appear at a variety of ages. The types of symptoms experienced, and their intensity, may vary among people with this disease. […] Common symptoms of problems in the nervous system include trouble moving, speaking, swallowing, breathing, or learning. Problems with memory, senses, or mood may also occur. […] The following describes the symptom(s) associated with this disease along with the corresponding body system(s), description, synonyms, and frequency: Headache, Increased Intracranial Pressure, Lethargy, Memory Impairment, Paralysis, Progressive Neurologic Deterioration, Reduced Consciousness, Seizure.

• #11 Pineoblastoma – Symptoms and causes – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/pineoblastoma/symptoms-causes/syc-20577723

  Pineoblastoma may cause headaches, sleepiness and changes in the way the eyes move. […] Pineoblastoma signs and symptoms include: Behavior changes. Headaches. Lack of energy. Nausea. Problems with memory and thinking. […] Pineoblastoma sometimes causes eye symptoms. This can happen when the cancer causes pressure on parts of the brain that help with vision. The eye symptoms that pineoblastoma causes are sometimes called Parinaud syndrome. Eye symptoms caused by pineoblastoma include: Blurred vision. Double vision. Problems focusing on objects that are up close. Problems looking upward. […] Pineoblastoma can be very difficult to treat. It can spread within the brain and into the fluid around the brain. This fluid is called cerebrospinal fluid. Pineoblastoma almost never spreads beyond the central nervous system.

• #12 Pineal Tumors: Symptoms, Diagnoses, and Treatment

  https://www.webmd.com/brain/what-to-know-about-pineal-tumors

  Pineal tumor symptoms are often associated with the feeling of pressure inside the skull. […] One of the most common symptoms is a condition called hydrocephalus. Hydrocephalus is a buildup of cerebrospinal fluid (CSF) in the brain, which leads to increased compression and can result in several symptoms: Early signs of puberty, Double vision, or diplopia, Headaches, Memory issues, Nausea, Poor balance and coordination, known as ataxia, Seizures, Trouble sleeping, Unusual eye movements, Vomiting. […] Pineal tumors can also impact the endocrine system, which helps the body regulate hormone levels and production. […] Pineoblastoma is classified as WHO grade 4, a fast-growing, malignant tumor likely to invade and spread to nearby tissue in the brain and spine. Pineoblastomas are aggressive and the most difficult to treat. They occur slightly more frequently in women and are most often diagnosed in people under 20.

• #13 What Is Pineoblastoma? | St. Baldrick’s Blog

  https://blog.stbaldricks.org/what-is-pineoblastoma/

  Pineoblastoma is more aggressive than other types of pineal gland tumors. Its fast growth usually causes cerebrospinal fluid to build up in the brain. In 10% to 20% of cases, the tumors spread to other parts of the body. […] Often, the growing tumor causes cerebrospinal fluid to build up in the brain, adding pressure. The increased pressure may cause some symptoms including: Nausea and vomiting, Headaches, Double vision, Eye movement problems, such as trouble looking up.

• #14 Pineoblastoma | The Brain Tumour Charity

  https://www.thebraintumourcharity.org/brain-tumour-diagnosis-treatment/types-brain-tumour-children/pineoblastoma/

  Pineoblastomas are more common in children than adults, mostly affecting people under 20. Symptoms include pressure in the skull, headaches, nausea, and abnormal eye movements. […] Here are some of the possible pineoblastoma symptoms: […] Due to their position, pineoblastomas often cause hydrocephalus. This is a build-up of pressure within the skull. […] The build-up in pressure (hydrocephalus) can also lead to headaches and feeling, or being, sick. […] Pineoblastoma symptoms often also include abnormal eye movements. […] Pineoblastomas are rare brain tumours. But, unfortunately, they are difficult to treat in the people who do develop them. Sadly, less than 10% of the children under the age of four with these brain tumours live for five years or more. However, over 60% of people aged over four years live for five years or more.

• #15 Pineal Region Tumors: Diagnosis and Treatment – NCI

  https://www.cancer.gov/rare-brain-spine-tumor/tumors/pineal-region-tumors

  Symptoms related to pineal region tumors depend on the tumors location. Pineal region tumors may cause increased pressure inside the skull due to too much production of CSF or blockage of its normal flow. This problem is known as hydrocephalus […] Signs and symptoms of hydrocephalus may include: […] Headaches […] Nausea […] Vomiting […] Difficulty with eye movements […] Difficulty with balance […] Difficulty walking.

• #16 Pineoblastoma – Symptoms, Diagnosis, and TreatmentSecond Opinion IconGroup 9Second Opinion IconGroup 9Group 49

  https://www.barrowneuro.org/condition/pineoblastoma/

  Vision problems: These tumors can also compress nearby structures, like the optic nerve, and lead to double vision, blurred vision, or difficulty moving the eyes up or down. This difficulty with up or down eye movement is often identified as Parinaud’s syndrome. […] Balance and coordination issues: If a pineoblastoma compresses parts of your brain that control motor skills, difficulties with balance and coordination can occur and show up as unusual clumsiness or unsteadiness. […] Memory and cognitive changes: The same pressure on nearby brain structures from a tumor can cause concentration, memory, and information processing and recall issues. […] Sleep disturbances: Because the pineal gland regulates sleep-wake cycles, pineoblastomas generally interfere with this cycle and can lead to insomnia or irregular sleep patterns.

• #17 Childhood Primitive Neuroectodermal Tumors (PNETs) and Pineoblastoma | Dana-Farber Cancer Institute

  https://www.dana-farber.org/cancer-care/types/childhood-primitive-neuroectodermal-tumors-pineoblastoma

  PNETs and pineoblastomas are aggressive tumors that tend to attach to parts of the brain that control movement, thought, and sensation. […] Symptoms depend on the location of the tumor, and each child may experience symptoms differently. […] Common symptoms include: Headache, Nausea and vomiting, Fatigue, Lethargy, Seizures, Behavior or personality changes, Unexplained weight loss or gain, Difficulty looking upward and weakness on one side of the body. […] The five-year survival of patients with PNETs or pineoblastoma is 50 to 60 percent. The outcomes are less favorable in infants and children who have partial surgical removal and an inadequate response to radiation therapy.

• #18 Pineoblastoma

  https://www.mymlc.com/health-information/diseases-and-conditions/p/pineoblastoma/

  Pineoblastoma can occur at any age, but it tends to occur most often in young children. Pineoblastoma may cause headaches, sleepiness and subtle changes in the way the eyes move. […] The signs and symptoms of a brain tumor vary greatly and depend on the brain tumor’s size, location and rate of growth. General signs and symptoms caused by brain tumors may include: New onset or change in pattern of headaches, Headaches that gradually become more frequent and more severe, Unexplained nausea or vomiting, Vision problems, such as blurred vision, double vision or loss of peripheral vision, Gradual loss of sensation or movement in an arm or a leg, Difficulty with balance, Speech difficulties, Confusion in everyday matters, Personality or behavior changes, Seizures, especially in someone who doesn’t have a history of seizures, Hearing problems.

• #19 Clinical Trials for Pineal-Region Tumors | Ivy Brain Tumor Center

  https://www.ivybraintumorcenter.org/brain-tumor-care/brain-tumor-types/pineal-region-tumors/

  Pineal- Region brain tumor symptoms, including pineocytoma and pineoblastoma, vary widely depending on the type, location, size and growth rate of the tumor. […] General symptoms of brain tumors include: New onset or change in pattern of headaches, Headaches that gradually become more frequent and more severe, New onset of seizures, Gradual loss of sensation or movement in an arm or a leg, Difficulty with balance, Difficulty speaking, Personality or behavior changes, Confusion, Unexplained nausea or vomiting, Blurred vision, double vision, or loss of peripheral vision, Hearing problems. […] Contact your physician if you are experiencing any of these symptoms.

• #20 Pineal Tumor | Cedars-Sinai

  https://www.cedars-sinai.org/health-library/diseases-and-conditions/p/pineal-tumor.html

  Fast-growing tumors may cause symptoms that worsen quickly. Some of the common symptoms of a pineal tumor include: Headaches (common). Nausea and vomiting. Vision changes. Trouble with eye movements. Feeling tired. Memory problems. Trouble walking. Balance or coordination problems. Growth and development delays in infants and children. […] Many of the symptoms of a pineal tumor can be caused by other health problems. Still, it’s important to see a health care provider for a diagnosis.

• #21 Pineoblastoma Overview | Expert Surgeon | Aaron Cohen-Gadol, MD | Aaron Cohen-Gadol, MD

  https://www.aaroncohen-gadol.com/en/patients/pineoblastoma/types/overview

  In children, pineoblastoma can sometimes affect hormonal balance, leading to early or delayed puberty. These symptoms can vary depending on tumor size and the extent of its spread, and because many of these can mimic other, less serious conditions, early diagnosis is often challenging. The gradual development of symptoms can sometimes lead to delays in seeking medical attention, further complicating timely diagnosis. […] Progression […] Prognosis varies widely based on factors such as the patients age, the extent of the tumor, and how well it responds to treatment. Generally, pineoblastomas are known to be aggressive tumors making outcomes difficult to predict. Survival rates tend to be lower for younger children, particularly under four years old, compared to adults due to differences in treatment response and the sensitivity of developing brains to aggressive therapies.

• #22 Pineoblastoma – Wikipedia

  https://en.wikipedia.org/wiki/Pineoblastoma

  Symptoms Nausea, vomiting, headache, double vision, problems with eye movement. […] The most common symptoms to occur with pineoblastoma are headache, behavior changes, and cognitive disturbances. These masses also often cause obstructive hydrocephalus, leading to increased intracranial pressure. This can result in vision changes and Parinaud’s syndrome. […] Due to the aggressive nature of the disease, tumor spread at the time of diagnosis is common. Pineoblastomas often invades locally, with spread to the head and spine seen in 25-41% of patients. While CNS spread is relatively common, these tumors rarely cause distant metastases.

• #23 Recent Advances in Pineoblastoma Research: Molecular Classification, Modelling and Targetable Vulnerabilities

  https://www.mdpi.com/2072-6694/17/5/720

  Metastatic PB characterize the RB1- and MYC- subtypes. Metastases are often observed in the spinal cord and brain, but rare metastases also occur outside of the central nervous system. […] Univariate analysis has established a correlation between children diagnosed at a young age (≤5 years) and an exceedingly poor prognosis. This relationship is amplified if the patient has metastatic disease at diagnosis, rendering treatment of these groups particularly challenging.

• #24 Pineoblastoma | Radiology Reference Article | Radiopaedia.org

  https://radiopaedia.org/articles/pineoblastoma?lang=us

  Pineoblastomas are typically large and almost always associated with obstructive hydrocephalus, due to compression of the cerebral aqueduct. […] They are highly malignant tumors prone to CSF seeding, which is present in 15% of patients at the time of diagnosis. […] Despite treatment, the prognosis has historically been poor, with a 5-year survival as low as 10%. In contrast, in 2021 a 5-year survival of 58-81% has been reported with median overall survival times of 4-8 years. […] The most important factors predicting a favorable outcome are early detection and treatment with at least chemotherapy, preferably a high dose regimen with stem cell rescue.

• #25 Pineoblastomas | EBSCO Research Starters

  https://www.ebsco.com/research-starters/health-and-medicine/pineoblastomas

  The prognosis for pineoblastomas varies with the child’s age and risk group, but it is typically poor, with an estimated survival time of sixteen to twenty-five months. Although some children do survive five years or more, the tumors commonly recur or develop in other parts of the body. When they do, they are almost always fatal. The five-year survival rate is between 60 and 70 percent, but it is much less when the child is younger than five years old. The survival rate is also dependent on the age of the patient, the severity of the tumor, and the treatment used.

• #26 Recent Advances in Pineoblastoma Research: Molecular Classification, Modelling and Targetable Vulnerabilities

  https://www.mdpi.com/2072-6694/17/5/720

  Pineoblastoma (PB) is a rare yet lethal pediatric brain cancer of the pineal gland, a small endocrine organ that secretes melatonin to regulate the circadian rhythm. For PB patients ≤5 years of age, the overall survival rate is approximately 15%; metastatic PB is incurable. Standard treatment, including surgical resection, radiation, and systemic chemotherapy, improves survival but compromises neurocognitive function. […] Common symptoms of PB include nausea, vomiting, ocular disturbances, headaches, fatigue, problems with coordination; weakness on one side of the body; seizures; diminished growth rate; and abnormal pupils, all of which are related to hydrocephalus, the buildup of cerebrospinal fluid in the brain. […] The overall survival (OS) rate of patients with PB is approximately 54–60%, but this varies dramatically in specific subtypes. Of 299 patients analyzed in one study, children older than 5 years showed better OS (5-year survival rate = 57%) compared to children ≤5 years old (5-year survival rate = 15%).

• #27

  https://braintumourresearch.org/blogs/types-of-brain-tumour/pineal-parenchymal-tumour-with-intermediate-differentiation-pptid?srsltid=AfmBOoqrRmIMJHXcS6EwA-w7k3hCyceT4ox9pEg-6c9ayDowX4Rd-GG5

  Signs and symptoms of pineal region tumours may include: Headaches, Nausea and vomiting, Unusual eye movements or difficulty controlling the eyes: in particular, a characteristic upward gaze palsy, known as Parinaud syndrome, Poor balance, for example whilst walking, Poor co-ordination (ataxia), Disruption of sleep patterns, Seizures, Memory issues, Early puberty in children. […] Unfortunately, progression to a grade 4 pineoblastoma occurs in almost 75% of papillary tumours of the pineal region (PTPRs) that are originally diagnosed as grade 2 or 3, so the prognosis for these tumour types is very dependent upon how the tumour responds to treatment and whether or not it progresses. […] Grade 4 pineoblastomas are rare but unfortunately they are very challenging to treat. For children under 4 years old, the 5 years overall survival rate is as low as 8.3%. For children over 4 years old, the 5 years overall survival rate rises to 66.7%. They are so rare in adults that no separate prognosis for adults has been clarified.

• #28 Prognostic factors and outcome of pineoblastoma: 10 years single-center experience | Journal of the Egyptian National Cancer Institute | Full Text

  https://jenci.springeropen.com/articles/10.1186/s43046-021-00083-3

  The survival of pineoblastoma patients is low, particularly in infants and those with metastatic disease. […] Symptoms result mainly from compression of the nearby structures, such as the tectum, resulting in ophthalmoplegia and obstructive hydrocephalus. […] The survival of patients with metastatic disease did not differ between age groups. However, age had a significant impact on the outcome of M0 disease, with 3-year EFS and OS of 65.3% and 74%, respectively, in the older group compared to 0% for both rates in younger patients. […] The presence of the metastatic disease did not affect survival in our study. […] However, it was apparent that young patients with metastatic disease showed a much lower cure rate, where 85% of the younger patients died from progressive disease compared to 56% in the older age group.

• #29 Pineoblastoma: Causes, Symptoms, Treatment & Prognosis

  https://my.clevelandclinic.org/health/diseases/24950-pineoblastoma

  Yes, some people may survive pineoblastoma. The five-year survival rate for pineoblastoma is 60% to 69.5%. This means that between 60% to nearly 70% of people with the condition are still alive five years later. While pineoblastoma can lead to a shortened life expectancy, treatment is available to help you feel better and help you live longer. […] A person’s life expectancy varies based on many factors, like your overall health, how you respond to treatment and the speed of tumor growth.

• #30 Pineoblastoma Overview | Expert Surgeon | Aaron Cohen-Gadol, MD | Aaron Cohen-Gadol, MD

  https://www.aaroncohen-gadol.com/en/patients/pineoblastoma/types/overview

  The overall survival rate depends on how early the tumor is detected, the success of surgical removal, and whether it has spread. Patients who receive a complete tumor removal followed by radiation and chemotherapy often have a better chance of long-term survival. […] Emerging therapies and improved surgical techniques have led to more favorable outcomes for many patients, and ongoing research continues to test new ways to improve survival rates and life expectancy. Advances in our understanding of cell biology have allowed for the development of personalized treatment approaches, helping clinicians tailor therapies to the specific characteristics of a patients tumor.

• #31 Treatment outcomes for pediatric pineoblastoma: a single institute experience in Taiwan – Kang – Therapeutic Radiology and Oncology

  https://tro.amegroups.org/article/view/4422/html

  Nausea and vomiting (81.8%) were the most common initial presenting symptoms, and headache (36.4%), unstable gait (18.2%), eye movement disturbance (18.2%), seizures (18.2%), limbs weakness (9.1%), and consciousness disturbance (9.1%) were also reported. […] Eight patients (72.7%) died after serial treatments, and extensive seeding with multi-organ failure was the most common failure pattern. […] The median overall survival time for the entire cohort was 2.3 years, with 2- and 5-year survival rates of 63.6%, and 36.4%, respectively. […] At the final follow-up, 3 patients (27.2%) were alive without disease recurrence. Among the living patients, one developed hypogonadotropic syndrome with short status at the age of 7, one experienced high pitch hearing lost at the age of 22, and the other patient did not develop any obvious complications during follow-up. […] Our results showed survival was associated with age at diagnosis. Long-term survival can be achieved for patients who receive radiotherapy plus chemotherapy.

• #32 Case Report of Symmetric Parkinsonism Secondary to a Pineoblastoma

  https://www.gavinpublishers.com/article/view/case-report-of-symmetric-parkinsonism-secondary-to-a-pineoblastoma

  Objectives: In order to identify and classify the types of a secondary Parkinsonism related to intra-axial tumors, a unique case involving a 17-year-old patient diagnosed with pineoblastoma is presented. This case highlights the rare secondary Parkinsonism symptoms associated with intra-axial tumors and emphasizes the need for comprehensive assessment and early intervention in uncommon brain tumor cases. […] We found the case of an adolescent with headaches, hydrocephalus and parkinsonian symptoms due to a pineal germ cell tumor who was treated with chemotherapy and levodopa/carbidopa resulting in clinical improvement. […] The symptoms of secondary parkinsonism in this case were unusually peculiar and included bradykinesia, rigidity and resting tremor. […] Upon clinical assessment by the Neurology service, the patient was awake, alert, oriented to person and circumstance, amimia; hyporeflective pupils, on primary gaze left palpebral ptosis was observed with right endotropia; ocular movements with limitation towards supra and infraversion of the gaze; as well as bilateral abduction, decreased bilateral corneal reflex, normal masseter reflex, facial diparesis, bilateral hearing loss, nerves IX, X, XI, XII without alterations. Extremities with symmetrical mobilization. Muscle stretch reflexes ++/++ in all extremities, absent Hoffman and Tromner signs, left extensor plantar response. Non-assessable gait. He presented global rigidity of all four extremities with the presence of symmetric upper extremities bradykinesia, with rest tremor ++, postural tremor +, without kinetic tremor which meets the symptom of parkinsonism in addition to a total score of 43 pts in Unified Parkinson Disease Rating Scale.

• #33 Pineoblastoma: Causes, Symptoms, & Treatment

  https://www.medicoverhospitals.in/diseases/pineoblastoma/

  Pineoblastoma presents differently in children compared to adults. In children, the tumor tends to grow more aggressively and is often associated with genetic syndromes like bilateral retinoblastoma. Adults, on the other hand, may experience slower tumor progression and slightly different symptoms. Understanding these distinctions is crucial for tailoring treatment approaches. […] The prognosis for pineoblastoma patients depends on several factors, including the patient’s age, the extent of tumor resection and the tumor’s response to treatment. Generally, younger patients and those who achieve complete tumor resection have a more favorable prognosis. However, due to the aggressive nature of the disease, long-term survival rates remain relatively low.

• #34 Childhood Medulloblastoma & Other CNS Embryonal Tumors Treatment – NCI

  https://www.cancer.gov/types/brain/patient/child-cns-embryonal-treatment-pdq

  Pineoblastoma forms in cells of the pineal gland. […] Symptoms of medulloblastoma, other CNS embryonal tumors, and pineoblastoma depend on the child’s age and where the tumor is. […] Children may not have symptoms of medulloblastoma, other CNS embryonal tumors, or pineoblastoma until the tumor has grown bigger. It’s important to check with your child’s doctor if your child has: loss of balance, trouble walking, lack of coordination, or slow speech; a headache, especially in the morning, or headache that goes away after vomiting; general weakness; weakness on one side of the face; unusual sleepiness or change in energy level; seizures; double vision or other eye problems; nausea and vomiting. […] Infants and young children with these tumors may be irritable or grow slowly. Also they may not eat well or meet developmental milestones such as sitting, walking, and talking in sentences. These tumors may also cause an increase in the size of an infant’s head. […] These symptoms may be caused by problems other than medulloblastoma, other CNS embryonal tumors, or pineoblastoma. The only way to know is to see your child’s doctor.

• #35 Pinealoma or Pineal Tumors: Symptoms, Causes, Diagnosis, Treatment

  https://www.healthline.com/health/pinealoma

  Pinealomas can disrupt childrens endocrine systems, which control hormones. When this happens, children can go through precocious puberty. This is when girls begin puberty before the age of 8 and boys before the age of 9. […] Symptoms of a larger pinealoma include: headaches, nausea, vomiting, vision problems, feeling tired, irritability, trouble with eye movements, balance issues, difficulty walking, tremors. […] Symptoms of precocious puberty include: breast growth in girls, testes growth in boys, rapid increase in height, changes in body size and shape, pubic or underarm hair, changes in body odor.

• #36 Final Diagnosis — Case 212

  https://path.upmc.edu/cases/case212/dx.html

  Pineoblastomas are quite rare in adults. These neoplasms usually occur before age 20, are slightly more common in males, and account for approximately 45% of pineal region tumors. Patients such as the one in this case commonly present with the signs and symptoms of obstructive hydrocephalus and/or Parinaud’s syndrome which is characterized by the following: upward gaze paralysis, normal vertical eye movement with doll’s head maneuver, nystagmus with downward gaze associated with bilateral eye retraction, paralysis of accommodation, midposition of pupils, and light-near dissociation. […] Therapeutic management of adults with pineoblastomas is controversial since such few cases exist in the literature. A combination of radiotherapy and chemotherapy is usually attempted. Prognosis is dismal regardless of therapy regimen. One series of adults with pineoblastoma had a median survival of 30 months (Chang et al., 1995). Another series showed a 49% five-year survival following various treatment modalities (Schild et al., 1997).

• #37 Adult Pineoblastoma: A Rare Case Report

  https://www.neurologyletters.com/article_200592.html

  Pineoblastoma (PB) is a rare brain tumor considered as a variant of supra-tentorial primitive neuroectodermal tumor. […] A 33-year-old male patient presented with headache vomiting. […] Though rare, Pineoblastoma needs to be considered a differential diagnosis of pineal region tumors in adults. […] Nearly all patients present with radiographic and clinical signs of hydrocephalus, including headache, double vision, blurry vision, and obtundation. […] One of the most striking clinical differences that we observed between adult patients and the reported pediatric patients is that progression-free survival and overall survival for adult patients are much higher than for children. […] Due to rarity optimal treatment strategies and prognosis of adult pineoblastoma are yet to be determined.

• #38 Pineoblastoma – Causes, Symptoms, Diagnosis, and Treatment

  https://www.apollohospitals.com/diseases-and-conditions/pineoblastoma

  Pineoblastoma can present with a variety of symptoms, which may vary depending on the tumor’s size and location. Common symptoms include: […] – Headaches: Persistent or worsening headaches, often due to increased intracranial pressure. – Vision Problems: Blurred vision, double vision, or difficulty focusing, which may occur if the tumor affects the optic pathways. – Nausea and Vomiting: These symptoms can result from increased pressure in the brain. – Balance and Coordination Issues: Difficulty walking or maintaining balance may occur if the tumor affects areas of the brain responsible for motor control. – Changes in Behavior or Personality: Cognitive changes, irritability, or mood swings may be observed, particularly in children. […] Certain symptoms may indicate the need for immediate medical attention, including: […] – Sudden onset of severe headaches – Rapid changes in vision – Loss of consciousness or seizures – Severe nausea and vomiting that does not improve […] Overall, early diagnosis and prompt treatment are critical for improving the prognosis of pineoblastoma.

• #39 Pineoblastoma – Brief information

  https://www.gpoh.de/kinderkrebsinfo/content/diseases/brain_tumours/pohpatinfomedullo120080109/literatur/index_eng.html

  Not all patients presenting with one or more of the symptoms mentioned above do have a pineoblastoma or another type of brain tumour. Many of these symptoms may also occur with other, harmless diseases that are not associated with a brain tumour at all. However, if certain symptoms persist or get worse (for example repetitive headaches or rapid increase of head circumference in a young child), a doctor should be seen to find the underlying reason. In case it is a brain tumour, treatment should be started as soon as possible.

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