Materiały źródłowe

• #1 Hodgkin Lymphoma — Cancer Stat Facts

  https://seer.cancer.gov/statfacts/html/hodg.html

  Estimated New Cases in 2025 8,720. […] % of All New Cancer Cases 0.4%. […] Estimated Deaths in 2025 1,150. […] % of All Cancer Deaths 0.2%. […] The rate of new cases of Hodgkin lymphoma was 2.5 per 100,000 men and women per year. The death rate was 0.3 per 100,000 men and women per year. These rates are age-adjusted and based on 2018-2022 cases and 2019-2023 deaths. […] Approximately 0.2 percent of men and women will be diagnosed with Hodgkin lymphoma at some point during their lifetime, based on 2018-2021 data, excluding 2020 due to COVID. […] In 2022, there were an estimated 233,860 people living with Hodgkin lymphoma in the United States. […] Hodgkin lymphoma represents 0.4% of all new cancer cases in the U.S. […] In 2025, it is estimated that there will be 8,720 new cases of Hodgkin lymphoma and an estimated 1,150 people will die of this disease.

• #1 Hodgkin Lymphoma Statistics | How Common Is Hodgkin Disease? | American Cancer Society

  https://www.cancer.org/cancer/types/hodgkin-lymphoma/about/key-statistics.html

  The American Cancer Societys estimates for Hodgkin lymphoma in the United States for 2025 are: […] About 8,720 new cases (4,840 in males and 3,880 in females) […] About 1,150 deaths (720 males and 430 females) […] Children and adults can develop Hodgkin lymphoma, but it’s most common in early adulthood (especially in a persons 20s). The risk of Hodgkin lymphoma rises again in late adulthood (after age 55). Overall, the average age of people when they are diagnosed is 39. […] Hodgkin lymphoma is rare in children younger than 5 years old. But it’s the most common cancer diagnosed in adolescents ages 15 to 19 years. […] Incidence rates have declined by about 1% each year for Hodgkin lymphoma since the mid-2000s.

• #2 Hodgkin lymphoma – Wikipedia

  https://en.wikipedia.org/wiki/Hodgkin_lymphoma

  Hodgkin lymphoma is a type of lymphoma in which cancer originates from a specific type of white blood cell called lymphocytes, where multinucleated Reed-Sternberg cells (RS cells) are present in the lymph nodes. […] About half of cases of Hodgkin lymphoma are due to Epstein-Barr virus (EBV) and these are generally the classic form. […] In 2015, about 574,000 people globally had Hodgkin lymphoma, and 23,900 (4.2%) died. […] Hodgkin lymphoma accounts for slightly less than 1% of all cancers worldwide. […] The number of cases of Hodgkin lymphoma is increased in people with infected with HIV. […] Hodgkin lymphoma accounts for 0.6% of all male cancer cases, and 0.4% of all female cancer cases in Canada. […] Hodgkin lymphoma accounts for less than 1% of all cancer cases and deaths in the United Kingdom. […] In 2016, there were 8,389 new cases and 1,000 mortalities attributed to Hodgkin lymphoma in the United States.

• #2 Hodgkin Lymphoma — Cancer Stat Facts

  https://seer.cancer.gov/statfacts/html/hodg.html

  Estimated New Cases in 2025 8,720. […] % of All New Cancer Cases 0.4%. […] Estimated Deaths in 2025 1,150. […] % of All Cancer Deaths 0.2%. […] The rate of new cases of Hodgkin lymphoma was 2.5 per 100,000 men and women per year. The death rate was 0.3 per 100,000 men and women per year. These rates are age-adjusted and based on 2018-2022 cases and 2019-2023 deaths. […] Approximately 0.2 percent of men and women will be diagnosed with Hodgkin lymphoma at some point during their lifetime, based on 2018-2021 data, excluding 2020 due to COVID. […] In 2022, there were an estimated 233,860 people living with Hodgkin lymphoma in the United States. […] Hodgkin lymphoma represents 0.4% of all new cancer cases in the U.S. […] In 2025, it is estimated that there will be 8,720 new cases of Hodgkin lymphoma and an estimated 1,150 people will die of this disease.

• #3 Hodgkin Lymphoma — Cancer Stat Facts

  https://seer.cancer.gov/statfacts/html/hodg.html

  Estimated New Cases in 2025 8,720. […] % of All New Cancer Cases 0.4%. […] Estimated Deaths in 2025 1,150. […] % of All Cancer Deaths 0.2%. […] The rate of new cases of Hodgkin lymphoma was 2.5 per 100,000 men and women per year. The death rate was 0.3 per 100,000 men and women per year. These rates are age-adjusted and based on 2018-2022 cases and 2019-2023 deaths. […] Approximately 0.2 percent of men and women will be diagnosed with Hodgkin lymphoma at some point during their lifetime, based on 2018-2021 data, excluding 2020 due to COVID. […] In 2022, there were an estimated 233,860 people living with Hodgkin lymphoma in the United States. […] Hodgkin lymphoma represents 0.4% of all new cancer cases in the U.S. […] In 2025, it is estimated that there will be 8,720 new cases of Hodgkin lymphoma and an estimated 1,150 people will die of this disease.

• #4 Incidence, mortality, risk factors, and trends for Hodgkin lymphoma: a global data analysis

  https://pmc.ncbi.nlm.nih.gov/articles/PMC9097358/

  Hodgkin lymphoma is a lymphatic malignancy commonly found in cervical lymph nodes. This study evaluated the worldwide incidence, mortality, associated risk factors, and temporal trends of Hodgkin lymphoma by sex, age, and country. […] The Hodgkin lymphoma incidence and mortality were 0.98 and 0.26 per 100,000 in 2020. A higher incidence was observed in high-income countries, while higher mortality was found in low-income countries. Incidence and mortality were associated with GDP per capita, prevalence of smoking, obesity, and hypertension at the population level. Despite the decreasing mortality trend, there was an increasing incidence, especially among females, younger population, and subjects from Asian countries. […] There was an increasing trend in Hodgkin lymphoma incidence, especially among subjects who were female, younger population, and from Asian countries. Further studies are needed to investigate the reasons for these epidemiologic trends.

• #5 Global patterns of Hodgkin lymphoma incidence and mortality in 2020 and a prediction of the future burden in 2040 – PubMed

  https://pubmed.ncbi.nlm.nih.gov/35080783/

  Our study examines global patterns of Hodgkin lymphoma (HL) in 2020 and predicts the future incidence and mortality burden in 2040 using IARC’s GLOBOCAN estimates of the number of new cases and deaths of HL in 185 countries. A total of 83 000 new cases of HL and 23 000 deaths from HL were estimated in 2020. […] Incidence rates varied markedly by world region, at least 10-fold in both sexes, with the highest incidence rates observed in Southern Europe. Mortality exhibited an inverse pattern compared to incidence, with rates elevated in Western Asia and Northern Africa. […] The number of HL incident cases is predicted to rise to around 107 000 cases (a 30% increase) by 2040 due to demographic changes, assuming global rates in 2020 remains unchanged. The findings provide a baseline and impetus for developing strategies that aim to reduce the burden of HL in future decades.

• #6 Hodgkin lymphoma – Wikipedia

  https://en.wikipedia.org/wiki/Hodgkin_lymphoma

  Hodgkin lymphoma is a type of lymphoma in which cancer originates from a specific type of white blood cell called lymphocytes, where multinucleated Reed-Sternberg cells (RS cells) are present in the lymph nodes. […] About half of cases of Hodgkin lymphoma are due to Epstein-Barr virus (EBV) and these are generally the classic form. […] In 2015, about 574,000 people globally had Hodgkin lymphoma, and 23,900 (4.2%) died. […] Hodgkin lymphoma accounts for slightly less than 1% of all cancers worldwide. […] The number of cases of Hodgkin lymphoma is increased in people with infected with HIV. […] Hodgkin lymphoma accounts for 0.6% of all male cancer cases, and 0.4% of all female cancer cases in Canada. […] Hodgkin lymphoma accounts for less than 1% of all cancer cases and deaths in the United Kingdom. […] In 2016, there were 8,389 new cases and 1,000 mortalities attributed to Hodgkin lymphoma in the United States.

• #7 Hodgkin Lymphoma Statistics | How Common Is Hodgkin Disease? | American Cancer Society

  https://www.cancer.org/cancer/types/hodgkin-lymphoma/about/key-statistics.html

  The American Cancer Societys estimates for Hodgkin lymphoma in the United States for 2025 are: […] About 8,720 new cases (4,840 in males and 3,880 in females) […] About 1,150 deaths (720 males and 430 females) […] Children and adults can develop Hodgkin lymphoma, but it’s most common in early adulthood (especially in a persons 20s). The risk of Hodgkin lymphoma rises again in late adulthood (after age 55). Overall, the average age of people when they are diagnosed is 39. […] Hodgkin lymphoma is rare in children younger than 5 years old. But it’s the most common cancer diagnosed in adolescents ages 15 to 19 years. […] Incidence rates have declined by about 1% each year for Hodgkin lymphoma since the mid-2000s.

• #8 Hodgkin Lymphoma — Cancer Stat Facts

  https://seer.cancer.gov/statfacts/html/hodg.html

  Hodgkin lymphoma is more common among young adults and among men than women. […] The rate of new cases of Hodgkin lymphoma was 2.5 per 100,000 men and women per year based on 2018-2022 cases, age-adjusted. […] The death rate was 0.3 per 100,000 men and women per year based on 2019-2023 deaths, age-adjusted. […] The percent of Hodgkin lymphoma deaths is highest among people aged 75-84. […] Keeping track of new cases, deaths, and survival over time (trends) can help scientists understand whether progress is being made and where additional research is needed to address challenges, such as improving screening or finding better treatments. […] Using statistical models for analysis, age-adjusted rates for new Hodgkin lymphoma cases have been falling on average 1.4% each year over 2013-2022. Age-adjusted death rates have been falling on average 2.3% each year over 2014-2023.

• #9 Hodgkin Lymphoma — Cancer Stat Facts

  https://seer.cancer.gov/statfacts/html/hodg.html

  Hodgkin lymphoma is more common among young adults and among men than women. […] The rate of new cases of Hodgkin lymphoma was 2.5 per 100,000 men and women per year based on 2018-2022 cases, age-adjusted. […] The death rate was 0.3 per 100,000 men and women per year based on 2019-2023 deaths, age-adjusted. […] The percent of Hodgkin lymphoma deaths is highest among people aged 75-84. […] Keeping track of new cases, deaths, and survival over time (trends) can help scientists understand whether progress is being made and where additional research is needed to address challenges, such as improving screening or finding better treatments. […] Using statistical models for analysis, age-adjusted rates for new Hodgkin lymphoma cases have been falling on average 1.4% each year over 2013-2022. Age-adjusted death rates have been falling on average 2.3% each year over 2014-2023.

• #10 Incidence, mortality, risk factors, and trends for Hodgkin lymphoma: a global data analysis

  https://pmc.ncbi.nlm.nih.gov/articles/PMC9097358/

  Hodgkin lymphoma is a lymphatic malignancy commonly found in cervical lymph nodes. This study evaluated the worldwide incidence, mortality, associated risk factors, and temporal trends of Hodgkin lymphoma by sex, age, and country. […] The Hodgkin lymphoma incidence and mortality were 0.98 and 0.26 per 100,000 in 2020. A higher incidence was observed in high-income countries, while higher mortality was found in low-income countries. Incidence and mortality were associated with GDP per capita, prevalence of smoking, obesity, and hypertension at the population level. Despite the decreasing mortality trend, there was an increasing incidence, especially among females, younger population, and subjects from Asian countries. […] There was an increasing trend in Hodgkin lymphoma incidence, especially among subjects who were female, younger population, and from Asian countries. Further studies are needed to investigate the reasons for these epidemiologic trends.

• #11 Incidence, mortality, risk factors, and trends for Hodgkin lymphoma: a global data analysis | Journal of Hematology & Oncology | Full Text

  https://jhoonline.biomedcentral.com/articles/10.1186/s13045-022-01281-9

  For the past decade, the overall Hodgkin lymphoma incidence rate has been increasing, especially among subjects who were female, younger population, and from Asian countries. The drivers for this trend remain unknown, but might be attributable to the increasing prevalence of lifestyle and metabolic risk factors as well as improvements in early diagnosis. The Hodgkin lymphoma mortality has been decreasing probably due to the early cancer diagnosis and advances in treatment. However, increasing Hodgkin lymphoma mortality rates were noted in Chile and Ireland. Further studies are needed to investigate the reasons for these epidemiologic trends and have a better understanding of the particular aetiology and prognosis of Hodgkin lymphoma.

• #12 Global patterns of Hodgkin lymphoma incidence and mortality in 2020 and a prediction of the future burden in 2040 – PubMed

  https://pubmed.ncbi.nlm.nih.gov/35080783/

  Our study examines global patterns of Hodgkin lymphoma (HL) in 2020 and predicts the future incidence and mortality burden in 2040 using IARC’s GLOBOCAN estimates of the number of new cases and deaths of HL in 185 countries. A total of 83 000 new cases of HL and 23 000 deaths from HL were estimated in 2020. […] Incidence rates varied markedly by world region, at least 10-fold in both sexes, with the highest incidence rates observed in Southern Europe. Mortality exhibited an inverse pattern compared to incidence, with rates elevated in Western Asia and Northern Africa. […] The number of HL incident cases is predicted to rise to around 107 000 cases (a 30% increase) by 2040 due to demographic changes, assuming global rates in 2020 remains unchanged. The findings provide a baseline and impetus for developing strategies that aim to reduce the burden of HL in future decades.

• #13 Hodgkin lymphoma incidence statistics | Cancer Research UK

  https://www.cancerresearchuk.org/health-professional/cancer-statistics/statistics-by-cancer-type/hodgkin-lymphoma/incidence

  Hodgkin lymphoma European age-standardised (AS) incidence rates for females and males combined increased by 38% in the UK between 1993-1995 and 2017-2019. […] For females, Hodgkin lymphoma AS incidence rates in the UK increased by 41% between 1993-1995 and 2017-2019. For males, Hodgkin lymphoma AS incidence rates in the UK increased by 36% between 1993-1995 and 2017-2019. […] Hodgkin lymphoma incidence rates have increased overall in most broad age groups in females and males combined in the UK since the early 1990s, but have remained stable in some. […] The number of new Hodgkin lymphoma cases on average each year in the UK is projected to rise from around 2,400 cases in 2023-2025 to around 2,900 cases in 2038-2040. […] Hodgkin lymphoma incidence rates are projected to rise by 13% in the UK between 2023-2025 and 2038-2040, to 4 cases per 100,000 people on average each year by 2038-2040.

• #14 Hodgkin lymphoma statistics | Cancer Research UK

  https://www.cancerresearchuk.org/health-professional/cancer-statistics/statistics-by-cancer-type/hodgkin-lymphoma

  Hodgkin lymphoma incidence rates are projected to rise by 13% in the UK between 2023-2025 and 2038-2040. […] There could be around 2,900 new cases of Hodgkin lymphoma every year in the UK by 2038-2040, projections suggest. […] Hodgkin lymphoma is not among the 20 most common causes of cancer death in the UK, accounting for less than 1% of all cancer deaths (2017-2019). […] Mortality rates for Hodgkin lymphoma in the UK are highest in people aged 85 to 89 (2017-2019). […] Since the early 1970s, Hodgkin lymphoma mortality rates have decreased by around three-quarters (74%) in the UK. Rates in females have decreased by more than seven-tenths (72%), and rates in males have decreased by around three-quarters (74%) (2017-2019). […] Hodgkin lymphoma mortality rates are projected to fall by 9% in the UK between 2023-2025 and 2038-2040.

• #15 Hodgkin Lymphoma: Practice Essentials, Background, Pathophysiology

  https://emedicine.medscape.com/article/201886-overview

  The incidence of Hodgkin lymphoma varies with age, with a clear bimodal distribution that is consistent across most countries and studies. The initial peak is in young adults (15-34 years); Hodgkin lymphoma is the most commonly diagnosed cancer in teens ages 15 to 19 years. The second peak is in older adults (55 years). There is also a difference in subtype based on age, with young adults having nodular sclerosing Hodgkin lymphoma (NSHL) and older adults tending to have mixed cellularity Hodgkin lymphoma (MCHL).

• #16 Hodgkin lymphoma | Radiology Reference Article | Radiopaedia.org

  https://radiopaedia.org/articles/hodgkin-lymphoma?lang=us

  Hodgkin lymphoma or Hodgkin disease (HD) is a type of lymphoma and accounts for ~1% of all cancers. Hodgkin disease spreads contiguously and predictably along lymphatic pathways and is curable in ~90% of cases, depending on its stage and subtype. […] There is a bimodal distribution in the age of affected patients, with peaks in young adults (15-34 years) and older patients (55 years). […] In contrast to other types of lymphoma, Hodgkin disease is usually characterized by a systematic nodal spread pattern making accurate staging important.

• #17 Hodgkin Lymphoma Statistics | How Common Is Hodgkin Disease? | American Cancer Society

  https://www.cancer.org/cancer/types/hodgkin-lymphoma/about/key-statistics.html

  The American Cancer Societys estimates for Hodgkin lymphoma in the United States for 2025 are: […] About 8,720 new cases (4,840 in males and 3,880 in females) […] About 1,150 deaths (720 males and 430 females) […] Children and adults can develop Hodgkin lymphoma, but it’s most common in early adulthood (especially in a persons 20s). The risk of Hodgkin lymphoma rises again in late adulthood (after age 55). Overall, the average age of people when they are diagnosed is 39. […] Hodgkin lymphoma is rare in children younger than 5 years old. But it’s the most common cancer diagnosed in adolescents ages 15 to 19 years. […] Incidence rates have declined by about 1% each year for Hodgkin lymphoma since the mid-2000s.

• #18 Hodgkin Lymphoma: Practice Essentials, Background, Pathophysiology

  https://emedicine.medscape.com/article/201886-overview

  The incidence of Hodgkin lymphoma varies with age, with a clear bimodal distribution that is consistent across most countries and studies. The initial peak is in young adults (15-34 years); Hodgkin lymphoma is the most commonly diagnosed cancer in teens ages 15 to 19 years. The second peak is in older adults (55 years). There is also a difference in subtype based on age, with young adults having nodular sclerosing Hodgkin lymphoma (NSHL) and older adults tending to have mixed cellularity Hodgkin lymphoma (MCHL).

• #19 Hodgkin Lymphoma Statistics | How Common Is Hodgkin Disease? | American Cancer Society

  https://www.cancer.org/cancer/types/hodgkin-lymphoma/about/key-statistics.html

  The American Cancer Societys estimates for Hodgkin lymphoma in the United States for 2025 are: […] About 8,720 new cases (4,840 in males and 3,880 in females) […] About 1,150 deaths (720 males and 430 females) […] Children and adults can develop Hodgkin lymphoma, but it’s most common in early adulthood (especially in a persons 20s). The risk of Hodgkin lymphoma rises again in late adulthood (after age 55). Overall, the average age of people when they are diagnosed is 39. […] Hodgkin lymphoma is rare in children younger than 5 years old. But it’s the most common cancer diagnosed in adolescents ages 15 to 19 years. […] Incidence rates have declined by about 1% each year for Hodgkin lymphoma since the mid-2000s.

• #20 Hodgkin Lymphoma: Practice Essentials, Background, Pathophysiology

  https://emedicine.medscape.com/article/201886-overview

  Data are also collected by the American Cancer Society (ACS). The ACS estimates that 8570 new cases of Hodgkin lymphoma will be diagnosed in 2024, and 910 deaths will occur. […] In Europe and other developed countries, the incidence parallels US data. United Kingdom data from 2016-2018 show a crude incidence rate of 3.2 cases per 100,000 population (3.8 cases per 100,000 males and 2.7 cases per 100,000 females). Since the early 1990s, incidence rates of Hodgkin lymphoma in the UK have risen 37%. […] Hodgkin lymphoma incidence rates in the United States vary by race and sex. The highest incidence is in non-Hispanic Whites; the lowest incidence is in American Indians/Alaska Natives and Asians/Pacific Islanders. In general, incidence is higher in males than in females. The sex predilection is most pronounced in children, with 85% of cases affecting boys.

• #21 Epidemiology – Primary Care Notebook

  https://primarycarenotebook.com/pages/haematology/hodgkins-disease/epidemiology

  Hodgkin lymphoma accounts for less than 1% of all cancers in the UK (2010) […] The annual incidence of Hodgkin lymphoma (HL) in the UK is 2.7/100,000 […] in 2010, there were 1,866 new cases of Hodgkin lymphoma in the UK […] 1,072 (57%) in males and 794 (43%) in females, giving a male:female ratio of more than 13:10 […] there is a peak in incidence in young adults ages 20-34 years with a further peak observed 70 years […] over half (55%) of men and women diagnosed with Hodgkin lymphoma present at stage I or II. For around a sixth (17%) of patients, the stage is not known […] There is wide international variation in the incidence of Hodgkin lymphoma […] the variation is similar for males and females […] the highest rates are in Southern Europe and Northern America […] in many parts of Asia and Africa, incidence rates for Hodgkin lymphoma are 1 per 100,000 population, with the world average being around 1.2 per 100,000 for males and 0.8 per 100,000 for females.

• #22 Azthena logo with the word Azthena

  https://www.news-medical.net/health/Hodgkins-Lymphoma-Epidemiology.aspx

  Hodgkins lymphoma is a rare cancer of the lymphatic system that affects the B-lymphocytes and leaves a patient susceptible to infection. […] Estimates suggest that around 1 in 25,000 people are affected by this cancer every year and the condition accounts for just under 1% of all cancers that occur worldwide. […] Although Hodgkins lymphoma can affect people of any age, it generally develops among two age groups in particular, which are those aged between 15 and 35 years and those aged over 55 years. […] The nodular sclerosis subtype is more common among females than males but otherwise, Hodgkins lymphoma is more common among males. […] Hodgkins lymphoma is more common among people with HIV infection, compared with the general population. […] According to the American Cancer Society, estimates for the United States suggest that in 2014, around 9,190 new cases of Hodgkins lymphoma will be diagnosed, involving 4,120 females and 5,070 males. […] Despite being an aggressive form of cancer, Hodgkins lymphoma is one of the most curable cancers, with the 1-year survival rate in the range of 90% to 95%. The 5- and 10-year respective survival rates are estimated to be around 85% and 80%.

• #23 Hodgkin Lymphoma: Practice Essentials, Background, Pathophysiology

  https://emedicine.medscape.com/article/201886-overview

  Data are also collected by the American Cancer Society (ACS). The ACS estimates that 8570 new cases of Hodgkin lymphoma will be diagnosed in 2024, and 910 deaths will occur. […] In Europe and other developed countries, the incidence parallels US data. United Kingdom data from 2016-2018 show a crude incidence rate of 3.2 cases per 100,000 population (3.8 cases per 100,000 males and 2.7 cases per 100,000 females). Since the early 1990s, incidence rates of Hodgkin lymphoma in the UK have risen 37%. […] Hodgkin lymphoma incidence rates in the United States vary by race and sex. The highest incidence is in non-Hispanic Whites; the lowest incidence is in American Indians/Alaska Natives and Asians/Pacific Islanders. In general, incidence is higher in males than in females. The sex predilection is most pronounced in children, with 85% of cases affecting boys.

• #24 Hodgkin Lymphoma Statistics | How Common Is Hodgkin Disease? | American Cancer Society

  https://www.cancer.org/cancer/types/hodgkin-lymphoma/about/key-statistics.html

  The American Cancer Societys estimates for Hodgkin lymphoma in the United States for 2025 are: […] About 8,720 new cases (4,840 in males and 3,880 in females) […] About 1,150 deaths (720 males and 430 females) […] Children and adults can develop Hodgkin lymphoma, but it’s most common in early adulthood (especially in a persons 20s). The risk of Hodgkin lymphoma rises again in late adulthood (after age 55). Overall, the average age of people when they are diagnosed is 39. […] Hodgkin lymphoma is rare in children younger than 5 years old. But it’s the most common cancer diagnosed in adolescents ages 15 to 19 years. […] Incidence rates have declined by about 1% each year for Hodgkin lymphoma since the mid-2000s.

• #25 Hodgkin lymphoma incidence statistics | Cancer Research UK

  https://www.cancerresearchuk.org/health-professional/cancer-statistics/statistics-by-cancer-type/hodgkin-lymphoma/incidence

  Hodgkin lymphoma is not among the 20 most common cancers in the UK, accounting for less than 1% of all new cancer cases (2017-2019). […] In females in the UK, Hodgkin lymphoma is not among the 20 most common cancers (less than 1% of all new female cancer cases). In males in the UK, it is the 19th most common cancer (less than 1% of all new male cancer cases). […] 42% of Hodgkin lymphoma cases in the UK are in females, and 58% are in males. […] Hodgkin lymphoma incidence rates (European age-standardised (AS) rate) for persons are similar to the UK average in all the UK constituent countries. […] In the UK in 2017-2019, on average each year almost 3 in 20 new cases (13%) were in people aged 75 and over. […] Age-specific incidence rates rise sharply during childhood and peak around age 20-29.

• #26 Global patterns of Hodgkin lymphoma incidence and mortality in 2020 and a prediction of the future burden in 2040 – PubMed

  https://pubmed.ncbi.nlm.nih.gov/35080783/

  Our study examines global patterns of Hodgkin lymphoma (HL) in 2020 and predicts the future incidence and mortality burden in 2040 using IARC’s GLOBOCAN estimates of the number of new cases and deaths of HL in 185 countries. A total of 83 000 new cases of HL and 23 000 deaths from HL were estimated in 2020. […] Incidence rates varied markedly by world region, at least 10-fold in both sexes, with the highest incidence rates observed in Southern Europe. Mortality exhibited an inverse pattern compared to incidence, with rates elevated in Western Asia and Northern Africa. […] The number of HL incident cases is predicted to rise to around 107 000 cases (a 30% increase) by 2040 due to demographic changes, assuming global rates in 2020 remains unchanged. The findings provide a baseline and impetus for developing strategies that aim to reduce the burden of HL in future decades.

• #27 Incidence, mortality, risk factors, and trends for Hodgkin lymphoma: a global data analysis | Journal of Hematology & Oncology | Full Text

  https://jhoonline.biomedcentral.com/articles/10.1186/s13045-022-01281-9

  The burden of Hodgkin lymphoma varies with gender sex, age, and geographical location. People with a higher risk of Hodgkin lymphoma include males, adolescents and young adults, those with past history of Epstein-Barr virus infection, HIV/AIDS, autoimmune diseases, exposure to pollution, cigarette smoking, and family history. […] The results are generally in line with previous research that found that the Hodgkin lymphoma incidence was higher in North America and Europe and lower in Africa, while its mortality was higher in Africa and lower in East Asia and Australia. […] We found that higher Hodgkin lymphoma burden was associated with prevalence of smoking, obesity, and hypertension at the population level, but not alcohol drinking. […] The increasing Hodgkin lymphoma incidence could be attributable to a better diagnostic capacity as well as an increasing rate of relevant risk factors.

• #28 Epidemiology – Primary Care Notebook

  https://primarycarenotebook.com/pages/haematology/hodgkins-disease/epidemiology

  Hodgkin lymphoma accounts for less than 1% of all cancers in the UK (2010) […] The annual incidence of Hodgkin lymphoma (HL) in the UK is 2.7/100,000 […] in 2010, there were 1,866 new cases of Hodgkin lymphoma in the UK […] 1,072 (57%) in males and 794 (43%) in females, giving a male:female ratio of more than 13:10 […] there is a peak in incidence in young adults ages 20-34 years with a further peak observed 70 years […] over half (55%) of men and women diagnosed with Hodgkin lymphoma present at stage I or II. For around a sixth (17%) of patients, the stage is not known […] There is wide international variation in the incidence of Hodgkin lymphoma […] the variation is similar for males and females […] the highest rates are in Southern Europe and Northern America […] in many parts of Asia and Africa, incidence rates for Hodgkin lymphoma are 1 per 100,000 population, with the world average being around 1.2 per 100,000 for males and 0.8 per 100,000 for females.

• #29 Epidemiology of hodgkin’s lymphoma

  https://www.scirp.org/html/3-8202086_31994.htm

  Epidemiology of Hodgkin’s Lymphoma (HL) varies with age at clinical onset. In developing countries, the disorder appears predominantly during childhood and its incidence decreases with age, while in industrialized countries, the incidence rate increases with age. There has long been a view that the differences in descriptive epidemiology of Hodgkin’s Lymphoma around the world, and also between children, young adults and older adults may reflect differences in etiology between them. Hodgkin’s Lymphoma has long been suspected to have an infectious precursor, and indirect evidence has implicated Epstein-Barr virus (EBV), as a causal agent. The etiology of EBV-negative cases remains obscure. Epidemiological investigation of the etiology of Hodgkin’s Lymphoma is making steady progress, and it leads to a better understanding and hence prevention. This review considers in detail the descriptive and the etiological epidemiology of Hodgkin’s Lymphoma.

• #30 Pediatric Hodgkin Lymphoma: Practice Essentials, Background, Pathophysiology

  https://emedicine.medscape.com/article/987101-overview

  A different age pattern is evident among economically disadvantaged populations in which there is an initial peak in childhood, particularly for boys. […] In the United States and in Western Europe, the childhood rate is lower than the young-adult rate. In Eastern Europe, the young-adult rate is similar to that observed in the United States and Western Europe, but the childhood rate is higher. Latin American countries have patterns of incidence approaching those of the United States. […] The incidence is relatively low in Asia, with the exception of South Asia, where the incidence is relatively high. […] In the United States, the incidence of Hodgkin lymphoma among Whites and Blacks is essentially the same. However, the ratio is 1.4:1 in children older than 10 years. A significant male-to-female ratio of 3:1 is observed in children younger than 10 years. Data from the National Cancer Institute show that 85% of cases occur in boys. In older children and adults, the male-to-female ratio is about 1:1.

• #31 Socioeconomic deprivation and regional variation in Hodgkin’s lymphoma incidence in the UK: a population-based cohort study of 10 million individuals | BMJ Open

  https://bmjopen.bmj.com/content/9/9/e029228

  Hodgkins lymphoma (HL) is the most common cancer in teenagers and young adults. This nationwide study conducted over a 25-year period in the UK investigates variation in HL incidence by age, sex, region and deprivation to identify trends and high-risk populations for HL development. […] A total of 2402 new cases of HL were identified over 78569436 person-years. There was significant variation in HL incidence by deprivation group. Individuals living in the most affluent areas had HL incidence 60% higher than those living in the most deprived (incidence rate ratios (IRR) 1.60, 95% CI 1.40 to 1.83), with strong evidence of a marked linear trend towards increasing HL incidence with decreasing deprivation (p=0.001). There was significant regional variation in HL incidence across the UK, which persisted after adjusting for age, sex and deprivation (IRR 0.801.42, p=0.001).

• #32 Socioeconomic deprivation and regional variation in Hodgkin’s lymphoma incidence in the UK: a population-based cohort study of 10 million individuals | BMJ Open

  https://bmjopen.bmj.com/content/9/9/e029228

  This study identified high-risk regions for HL development in the UK and observed a trend towards higher incidence of HL in individuals living in less deprived areas. Consistent with findings from other immune-mediated diseases, this study supports the hypothesis that an affluent childhood environment may predispose to development of immune-related neoplasms, potentially through fewer immune challenges interfering with immune maturation in early life. Understanding the mechanisms behind this immune dysfunction could inform prevention, detection and treatment of HL and other immune diseases. […] In the UK, 2100 new cases of HL are diagnosed each year, but little is known about the distribution of these cases in the UK population or if there are any high-risk groups. […] Understanding how HL incidence varies between different geographical regions in the UK and identifying high-risk populations may provide clues to the underlying aetiology of the disease and inform future research directions.

• #33 Hodgkin lymphoma – Wikipedia

  https://en.wikipedia.org/wiki/Hodgkin_lymphoma

  Hodgkin lymphoma is a type of lymphoma in which cancer originates from a specific type of white blood cell called lymphocytes, where multinucleated Reed-Sternberg cells (RS cells) are present in the lymph nodes. […] About half of cases of Hodgkin lymphoma are due to Epstein-Barr virus (EBV) and these are generally the classic form. […] In 2015, about 574,000 people globally had Hodgkin lymphoma, and 23,900 (4.2%) died. […] Hodgkin lymphoma accounts for slightly less than 1% of all cancers worldwide. […] The number of cases of Hodgkin lymphoma is increased in people with infected with HIV. […] Hodgkin lymphoma accounts for 0.6% of all male cancer cases, and 0.4% of all female cancer cases in Canada. […] Hodgkin lymphoma accounts for less than 1% of all cancer cases and deaths in the United Kingdom. […] In 2016, there were 8,389 new cases and 1,000 mortalities attributed to Hodgkin lymphoma in the United States.

• #34 Hodgkin’s Lymphoma | Doctor

  https://patient.info/doctor/hodgkins-lymphoma-pro

  Hodgkin’s lymphoma is a malignant tumour of the lymphatic system that is characterised histologically by the presence of multinucleated giant cells (Reed-Sternberg cells) and associated abnormal and smaller mononuclear cells originating from B lymphocytes in the germinal centres of lymphoid tissue. […] The annual incidence of Hodgkin’s lymphoma in the UK is 2.7/100,000 with a slight male predominance. […] There is a peak in incidence in young adults aged 20-34 years, with a further peak observed over 70 years. […] EBV has been found in the Reed-Sternberg cells of about 50% of patients with Hodgkin’s lymphoma. […] Patients who have previously developed mononucleosis have an increased risk of developing Hodgkin’s lymphoma. […] Other risk factors include human immunodeficiency virus (HIV), immunosuppression and cigarette smoking.

• #35 Hodgkin lymphoma (Hodgkin disease) – Symptoms and causes – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/hodgkins-lymphoma/symptoms-causes/syc-20352646

  Factors that can increase the risk of Hodgkin lymphoma include: Your age. Hodgkin lymphoma is most often diagnosed in people in their 20s and 30s and those over age 65. A family history of Hodgkin lymphoma. Having a blood relative with Hodgkin lymphoma increases the risk of Hodgkin lymphoma. Being male. People who are assigned male at birth are slightly more likely to develop Hodgkin lymphoma than are those who are assigned female at birth. Past Epstein-Barr infection. People who have had illnesses caused by the Epstein-Barr virus are at higher risk of Hodgkin lymphoma than are those who haven’t. One example is infectious mononucleosis. HIV infection. People who are infected with HIV have an increased risk of Hodgkin lymphoma. […] There’s no way to prevent Hodgkin lymphoma.

• #36 Role of the Primary Care Physician in Hodgkin Lymphoma | AAFP

  https://www.aafp.org/pubs/afp/issues/2008/0901/p615.html

  Approximately 8,200 new cases of Hodgkin lymphoma are diagnosed annually in the United States. […] Hodgkin lymphoma accounts for about one seventh of all lymphomas, with approximately 8,200 cases expected to be diagnosed in the United States in 2008. Hodgkin lymphoma has a bimodal incidence pattern, with one peak in persons 15 to 34 years of age, and the other in persons older than 60 years. […] Patients with immunosuppressive conditions have an increased risk of Hodgkin lymphoma. Those with human immunodeficiency virus (HIV) infection and acquired immunodeficiency syndrome are approximately 10 times more likely than the general population to develop Hodgkin lymphoma. […] Familial factors may also play a role in the etiology of Hodgkin lymphoma. Same-sex siblings of patients have been found to have a 10-fold higher risk of developing the disease.

• #37 Role of the Primary Care Physician in Hodgkin Lymphoma | AAFP

  https://www.aafp.org/pubs/afp/issues/2008/0901/p615.html

  Approximately 8,200 new cases of Hodgkin lymphoma are diagnosed annually in the United States. […] Hodgkin lymphoma accounts for about one seventh of all lymphomas, with approximately 8,200 cases expected to be diagnosed in the United States in 2008. Hodgkin lymphoma has a bimodal incidence pattern, with one peak in persons 15 to 34 years of age, and the other in persons older than 60 years. […] Patients with immunosuppressive conditions have an increased risk of Hodgkin lymphoma. Those with human immunodeficiency virus (HIV) infection and acquired immunodeficiency syndrome are approximately 10 times more likely than the general population to develop Hodgkin lymphoma. […] Familial factors may also play a role in the etiology of Hodgkin lymphoma. Same-sex siblings of patients have been found to have a 10-fold higher risk of developing the disease.

• #38 Incidence, mortality, risk factors, and trends for Hodgkin lymphoma: a global data analysis | Journal of Hematology & Oncology | Full Text

  https://jhoonline.biomedcentral.com/articles/10.1186/s13045-022-01281-9

  The burden of Hodgkin lymphoma varies with gender sex, age, and geographical location. People with a higher risk of Hodgkin lymphoma include males, adolescents and young adults, those with past history of Epstein-Barr virus infection, HIV/AIDS, autoimmune diseases, exposure to pollution, cigarette smoking, and family history. […] The results are generally in line with previous research that found that the Hodgkin lymphoma incidence was higher in North America and Europe and lower in Africa, while its mortality was higher in Africa and lower in East Asia and Australia. […] We found that higher Hodgkin lymphoma burden was associated with prevalence of smoking, obesity, and hypertension at the population level, but not alcohol drinking. […] The increasing Hodgkin lymphoma incidence could be attributable to a better diagnostic capacity as well as an increasing rate of relevant risk factors.

• #39 Incidence, mortality, risk factors, and trends for Hodgkin lymphoma: a global data analysis | Journal of Hematology & Oncology | Full Text

  https://jhoonline.biomedcentral.com/articles/10.1186/s13045-022-01281-9

  The burden of Hodgkin lymphoma varies with gender sex, age, and geographical location. People with a higher risk of Hodgkin lymphoma include males, adolescents and young adults, those with past history of Epstein-Barr virus infection, HIV/AIDS, autoimmune diseases, exposure to pollution, cigarette smoking, and family history. […] The results are generally in line with previous research that found that the Hodgkin lymphoma incidence was higher in North America and Europe and lower in Africa, while its mortality was higher in Africa and lower in East Asia and Australia. […] We found that higher Hodgkin lymphoma burden was associated with prevalence of smoking, obesity, and hypertension at the population level, but not alcohol drinking. […] The increasing Hodgkin lymphoma incidence could be attributable to a better diagnostic capacity as well as an increasing rate of relevant risk factors.

• #40 Hodgkin lymphoma (Hodgkin disease) – Symptoms and causes – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/hodgkins-lymphoma/symptoms-causes/syc-20352646

  Factors that can increase the risk of Hodgkin lymphoma include: Your age. Hodgkin lymphoma is most often diagnosed in people in their 20s and 30s and those over age 65. A family history of Hodgkin lymphoma. Having a blood relative with Hodgkin lymphoma increases the risk of Hodgkin lymphoma. Being male. People who are assigned male at birth are slightly more likely to develop Hodgkin lymphoma than are those who are assigned female at birth. Past Epstein-Barr infection. People who have had illnesses caused by the Epstein-Barr virus are at higher risk of Hodgkin lymphoma than are those who haven’t. One example is infectious mononucleosis. HIV infection. People who are infected with HIV have an increased risk of Hodgkin lymphoma. […] There’s no way to prevent Hodgkin lymphoma.

• #41 Hodgkin Lymphoma: Practice Essentials, Background, Pathophysiology

  https://emedicine.medscape.com/article/201886-overview

  Hodgkin lymphoma is a potentially curable lymphoma. The World Health Organization categorizes Hodgkin lymphoma as classic or nodular lymphocyte-predominant and divides classic Hodgkin lymphoma into four types, as follows: Nodular sclerosis, Mixed cellularity, Lymphocyte depleted, Lymphocyte rich. […] Information regarding the incidence and mortality of Hodgkin lymphoma in the United States can be found at the National Cancer Institute (NCI) Surveillance Epidemiology and End Results (SEER) database Website. The NCI reports that age-adjusted rates for new Hodgkin lymphoma cases have been falling on average 2.3% each year over the last 10 years. As of 2017-2021, the age-adjusted annual incidence was 2.5 cases per 100,000 population. Death rates have decreased slowly but steadily in recent decades, but were stable at 0.3 per 100,000 population per year over 2017-2021.

• #42 Pathology Outlines – Classic Hodgkin lymphoma

  https://www.pathologyoutlines.com/topic/lymphomanonBclassic.html

  Classic Hodgkin lymphoma (CHL): B cell derived lymphoma characterized by distinctive immunophenotype and relatively few malignant cells in a nonneoplastic inflammatory background. […] 4 subgroups (nodular sclerosis, mixed cellularity, lymphocyte rich, lymphocyte depleted) with distinct clinical, morphologic and epidemiologic characteristics. […] CHL: ~90 – 95% of Hodgkin lymphomas. […] Epidemiology varies by subgroup (Br J Haematol 2019;184:45). […] Nodular sclerosis (~70% of CHL in Western countries) […] Mixed cellularity (~20% of CHL) […] Lymphocyte rich (~5% of CHL) […] Lymphocyte depleted (< 1% of CHL in Western countries).

• #43 Pathology Outlines – Classic Hodgkin lymphoma

  https://www.pathologyoutlines.com/topic/lymphomanonBclassic.html

  Classic Hodgkin lymphoma (CHL): B cell derived lymphoma characterized by distinctive immunophenotype and relatively few malignant cells in a nonneoplastic inflammatory background. […] 4 subgroups (nodular sclerosis, mixed cellularity, lymphocyte rich, lymphocyte depleted) with distinct clinical, morphologic and epidemiologic characteristics. […] CHL: ~90 – 95% of Hodgkin lymphomas. […] Epidemiology varies by subgroup (Br J Haematol 2019;184:45). […] Nodular sclerosis (~70% of CHL in Western countries) […] Mixed cellularity (~20% of CHL) […] Lymphocyte rich (~5% of CHL) […] Lymphocyte depleted (< 1% of CHL in Western countries).

• #44 Azthena logo with the word Azthena

  https://www.news-medical.net/health/Hodgkins-Lymphoma-Epidemiology.aspx

  Hodgkins lymphoma is a rare cancer of the lymphatic system that affects the B-lymphocytes and leaves a patient susceptible to infection. […] Estimates suggest that around 1 in 25,000 people are affected by this cancer every year and the condition accounts for just under 1% of all cancers that occur worldwide. […] Although Hodgkins lymphoma can affect people of any age, it generally develops among two age groups in particular, which are those aged between 15 and 35 years and those aged over 55 years. […] The nodular sclerosis subtype is more common among females than males but otherwise, Hodgkins lymphoma is more common among males. […] Hodgkins lymphoma is more common among people with HIV infection, compared with the general population. […] According to the American Cancer Society, estimates for the United States suggest that in 2014, around 9,190 new cases of Hodgkins lymphoma will be diagnosed, involving 4,120 females and 5,070 males. […] Despite being an aggressive form of cancer, Hodgkins lymphoma is one of the most curable cancers, with the 1-year survival rate in the range of 90% to 95%. The 5- and 10-year respective survival rates are estimated to be around 85% and 80%.

• #45 Pathology Outlines – Classic Hodgkin lymphoma

  https://www.pathologyoutlines.com/topic/lymphomanonBclassic.html

  Classic Hodgkin lymphoma (CHL): B cell derived lymphoma characterized by distinctive immunophenotype and relatively few malignant cells in a nonneoplastic inflammatory background. […] 4 subgroups (nodular sclerosis, mixed cellularity, lymphocyte rich, lymphocyte depleted) with distinct clinical, morphologic and epidemiologic characteristics. […] CHL: ~90 – 95% of Hodgkin lymphomas. […] Epidemiology varies by subgroup (Br J Haematol 2019;184:45). […] Nodular sclerosis (~70% of CHL in Western countries) […] Mixed cellularity (~20% of CHL) […] Lymphocyte rich (~5% of CHL) […] Lymphocyte depleted (< 1% of CHL in Western countries).

• #46 Pathology Outlines – Classic Hodgkin lymphoma

  https://www.pathologyoutlines.com/topic/lymphomanonBclassic.html

  Classic Hodgkin lymphoma (CHL): B cell derived lymphoma characterized by distinctive immunophenotype and relatively few malignant cells in a nonneoplastic inflammatory background. […] 4 subgroups (nodular sclerosis, mixed cellularity, lymphocyte rich, lymphocyte depleted) with distinct clinical, morphologic and epidemiologic characteristics. […] CHL: ~90 – 95% of Hodgkin lymphomas. […] Epidemiology varies by subgroup (Br J Haematol 2019;184:45). […] Nodular sclerosis (~70% of CHL in Western countries) […] Mixed cellularity (~20% of CHL) […] Lymphocyte rich (~5% of CHL) […] Lymphocyte depleted (< 1% of CHL in Western countries).

• #47 Pathology Outlines – Classic Hodgkin lymphoma

  https://www.pathologyoutlines.com/topic/lymphomanonBclassic.html

  Classic Hodgkin lymphoma (CHL): B cell derived lymphoma characterized by distinctive immunophenotype and relatively few malignant cells in a nonneoplastic inflammatory background. […] 4 subgroups (nodular sclerosis, mixed cellularity, lymphocyte rich, lymphocyte depleted) with distinct clinical, morphologic and epidemiologic characteristics. […] CHL: ~90 – 95% of Hodgkin lymphomas. […] Epidemiology varies by subgroup (Br J Haematol 2019;184:45). […] Nodular sclerosis (~70% of CHL in Western countries) […] Mixed cellularity (~20% of CHL) […] Lymphocyte rich (~5% of CHL) […] Lymphocyte depleted (< 1% of CHL in Western countries).

• #48

  https://esmed.org/MRA/index.php/mra/article/view/658

  Hodgkin lymphoma shows a well-known geographic pattern. Incidence also varies significantly by age, sex, ethnicity and socioeconomic status. These clinical pathological features of the disease are changing. […] 715 Hodgkin lymphoma patients clinicopathological and treatment data were assessed in a maximum of ten-year periods. The patients were treated at the University of Debrecen, Department of Hematology from 1980 until the end of 2014. […] The incidence of classical mixed cellularity (cMC) histological subtype is decreasing (38%, 49%, 48% and 26%; p 0.01) while classical nodular sclerosis (cNS) shows an increasing tendency (21%, 28%, 30% and 50%; p 0.01). […] The changing patterns can be explained by the altered nature of the disease, changes in immunological features, environmental factors, socioeconomic status and development of diagnostic and therapy methods.

• #49

  https://esmed.org/MRA/mra/article/view/658

  Hodgkin lymphoma shows a well-known geographic pattern. Incidence also varies significantly by age, sex, ethnicity and socioeconomic status. These clinical pathological features of the disease are changing. […] The incidence of classical mixed cellularity (cMC) histological subtype is decreasing (38%, 49%, 48% and 26%; p 0.01) while classical nodular sclerosis (cNS) shows an increasing tendency (21%, 28%, 30% and 50%; p 0.01). […] The changing patterns can be explained by the altered nature of the disease, changes in immunological features, environmental factors, socioeconomic status and development of diagnostic and therapy methods.

• #50 Hodgkin Lymphoma has a seasonal pattern of incidence and mortality that depends on latitude | Scientific Reports

  https://www.nature.com/articles/s41598-017-14805-y

  Seasonal variations in incidence and mortality after a Hodgkin lymphoma (HL) diagnosis have been previously described with partly conflicting results. The goal of this analysis is to provide a comprehensive analysis of these seasonal variations. In total, 41,405 HL cases diagnosed between 1973 and 2012 in the 18 Surveillance, Epidemiology, and End Results registries were included. HL shows a sinusoid seasonal incidence pattern (p0.001). Estimated incidence in March is 15.4% [95%-CI: 10.8-20.0] higher than in September. This sinusoid pattern is more pronounced at higher latitudes (p=0.023). The risk of dying within the first three years after a HL diagnosis in winter is significantly increased compared to a HL diagnosis in summer at higher latitudes (HR=1.082 [95%-CI: 1.009-1.161], p=0.027). Furthermore, increasing northern latitude increases the additional mortality risk conferred by a diagnosis in winter (pinteraction0.033). The seasonality patterns presented here provide epidemiological evidence that Vitamin D might play a protective role in HL.

• #51 Hodgkin Lymphoma has a seasonal pattern of incidence and mortality that depends on latitude | Scientific Reports

  https://www.nature.com/articles/s41598-017-14805-y

  Seasonal variations in incidence and mortality after a Hodgkin lymphoma (HL) diagnosis have been previously described with partly conflicting results. The goal of this analysis is to provide a comprehensive analysis of these seasonal variations. In total, 41,405 HL cases diagnosed between 1973 and 2012 in the 18 Surveillance, Epidemiology, and End Results registries were included. HL shows a sinusoid seasonal incidence pattern (p0.001). Estimated incidence in March is 15.4% [95%-CI: 10.8-20.0] higher than in September. This sinusoid pattern is more pronounced at higher latitudes (p=0.023). The risk of dying within the first three years after a HL diagnosis in winter is significantly increased compared to a HL diagnosis in summer at higher latitudes (HR=1.082 [95%-CI: 1.009-1.161], p=0.027). Furthermore, increasing northern latitude increases the additional mortality risk conferred by a diagnosis in winter (pinteraction0.033). The seasonality patterns presented here provide epidemiological evidence that Vitamin D might play a protective role in HL.

• #52 Hodgkin Lymphoma has a seasonal pattern of incidence and mortality that depends on latitude | Scientific Reports

  https://www.nature.com/articles/s41598-017-14805-y

  Seasonal variations in incidence and mortality after a Hodgkin lymphoma (HL) diagnosis have been previously described with partly conflicting results. The goal of this analysis is to provide a comprehensive analysis of these seasonal variations. In total, 41,405 HL cases diagnosed between 1973 and 2012 in the 18 Surveillance, Epidemiology, and End Results registries were included. HL shows a sinusoid seasonal incidence pattern (p0.001). Estimated incidence in March is 15.4% [95%-CI: 10.8-20.0] higher than in September. This sinusoid pattern is more pronounced at higher latitudes (p=0.023). The risk of dying within the first three years after a HL diagnosis in winter is significantly increased compared to a HL diagnosis in summer at higher latitudes (HR=1.082 [95%-CI: 1.009-1.161], p=0.027). Furthermore, increasing northern latitude increases the additional mortality risk conferred by a diagnosis in winter (pinteraction0.033). The seasonality patterns presented here provide epidemiological evidence that Vitamin D might play a protective role in HL.

• #53 Hodgkin Lymphoma has a seasonal pattern of incidence and mortality that depends on latitude | Scientific Reports

  https://www.nature.com/articles/s41598-017-14805-y

  We hypothesize that seasonal differences in vitamin D levels mediated by ultraviolet radiation (UVR) are at least in part responsible for the seasonal patterns described here. The seasonal pattern of vitamin D levels in humans is also more pronounced at higher latitudes. Strikingly, the seasonal incidence pattern observed in HL cases almost exactly resembles the seasonal pattern of vitamin D levels in humans. […] In conclusion, we found a striking seasonal pattern of incidence and mortality in HL. Further studies are needed in order to better understand the reasons for the seasonal patterns described here.

• #54 Azthena logo with the word Azthena

  https://www.news-medical.net/health/Hodgkins-Lymphoma-Epidemiology.aspx

  Hodgkins lymphoma is a rare cancer of the lymphatic system that affects the B-lymphocytes and leaves a patient susceptible to infection. […] Estimates suggest that around 1 in 25,000 people are affected by this cancer every year and the condition accounts for just under 1% of all cancers that occur worldwide. […] Although Hodgkins lymphoma can affect people of any age, it generally develops among two age groups in particular, which are those aged between 15 and 35 years and those aged over 55 years. […] The nodular sclerosis subtype is more common among females than males but otherwise, Hodgkins lymphoma is more common among males. […] Hodgkins lymphoma is more common among people with HIV infection, compared with the general population. […] According to the American Cancer Society, estimates for the United States suggest that in 2014, around 9,190 new cases of Hodgkins lymphoma will be diagnosed, involving 4,120 females and 5,070 males. […] Despite being an aggressive form of cancer, Hodgkins lymphoma is one of the most curable cancers, with the 1-year survival rate in the range of 90% to 95%. The 5- and 10-year respective survival rates are estimated to be around 85% and 80%.

• #55 Hodgkin lymphoma statistics | Cancer Research UK

  https://www.cancerresearchuk.org/health-professional/cancer-statistics/statistics-by-cancer-type/hodgkin-lymphoma

  3 in 4 (75.0%) people diagnosed with Hodgkin lymphoma in England survive their disease for ten years or more, it is predicted (2013-2017). […] Hodgkin lymphoma ten-year survival in England is similar in females and males (2013-2017). […] More than 9 in 10 (94.2%) of people in England diagnosed with Hodgkin lymphoma aged 15-44 survive their disease for ten years or more, compared with almost 4 in 10 (36.7%) people diagnosed aged 65-99 (2013-2017). […] Hodgkin lymphoma survival has increased in the last 50 years in the UK. […] 40% of Hodgkin lymphoma cases in the UK are preventable. […] 40% of Hodgkin lymphoma cases in the UK are caused by infections.

• #56 Hodgkin lymphoma statistics | Cancer Research UK

  https://www.cancerresearchuk.org/health-professional/cancer-statistics/statistics-by-cancer-type/hodgkin-lymphoma

  3 in 4 (75.0%) people diagnosed with Hodgkin lymphoma in England survive their disease for ten years or more, it is predicted (2013-2017). […] Hodgkin lymphoma ten-year survival in England is similar in females and males (2013-2017). […] More than 9 in 10 (94.2%) of people in England diagnosed with Hodgkin lymphoma aged 15-44 survive their disease for ten years or more, compared with almost 4 in 10 (36.7%) people diagnosed aged 65-99 (2013-2017). […] Hodgkin lymphoma survival has increased in the last 50 years in the UK. […] 40% of Hodgkin lymphoma cases in the UK are preventable. […] 40% of Hodgkin lymphoma cases in the UK are caused by infections.

• #57 Hodgkin lymphoma statistics | Cancer Research UK

  https://www.cancerresearchuk.org/health-professional/cancer-statistics/statistics-by-cancer-type/hodgkin-lymphoma

  3 in 4 (75.0%) people diagnosed with Hodgkin lymphoma in England survive their disease for ten years or more, it is predicted (2013-2017). […] Hodgkin lymphoma ten-year survival in England is similar in females and males (2013-2017). […] More than 9 in 10 (94.2%) of people in England diagnosed with Hodgkin lymphoma aged 15-44 survive their disease for ten years or more, compared with almost 4 in 10 (36.7%) people diagnosed aged 65-99 (2013-2017). […] Hodgkin lymphoma survival has increased in the last 50 years in the UK. […] 40% of Hodgkin lymphoma cases in the UK are preventable. […] 40% of Hodgkin lymphoma cases in the UK are caused by infections.

• #58 Factors Linked to Improved Survival in Hodgkin Lymphoma

  https://consultqd.clevelandclinic.org/outcomes-in-hodgkin-lymphoma-are-improving-but-disparities-persist

  Improvements in survival from Hodgkin lymphoma (HL) are one of the greatest medical accomplishments of the past half-century with event-free and overall survival rates now exceeding 85% and 90%, respectively. […] Despite these achievements, racial, ethnic and age-related disparities in outcomes have persisted over time. […] Inferior HL outcomes are reported in non-Hispanic Black and Hispanic populations as compared to white populations and in AYAs as compared to children. […] Intermediaries associated with this outcome disparity include stage at presentation, receiving care at specialized cancer centers, receipt of multimodal therapy, and enrollment in a clinical treatment trial. […] Racial and ethnic disparities in relapse are mitigated by enrollment on clinical trial. However, survival disparities in post-relapse mortality persist in the trial setting.

• #59

  https://www.haematologica.org/article/view/6335

  The value of performing post-therapy routine surveillance imaging in patients with Hodgkin lymphoma is controversial. This study evaluates the utility of positron emission tomography/computed tomography using 2-[18F]fluoro-2-deoxyglucose for this purpose and in situations with suspected lymphoma relapse. […] The overall positive predictive value and negative predictive value of positron emission tomography/computed tomography were 28% and 100%, respectively. […] With no proven survival benefit for patients with a pre-clinically diagnosed relapse, the high costs and low positive predictive value make positron emission tomography/computed tomography unsuitable for routine surveillance of patients with Hodgkin lymphoma. […] The estimated cost per routine imaging diagnosed relapse was US$ 50,778.

• #60

  https://haematologica.org/article/view/6335

  The value of performing post-therapy routine surveillance imaging in patients with Hodgkin lymphoma is controversial. […] This study evaluates the utility of positron emission tomography/computed tomography using 2-[18F]fluoro-2-deoxyglucose for this purpose and in situations with suspected lymphoma relapse. […] The overall positive predictive value and negative predictive value of positron emission tomography/computed tomography were 28% and 100%, respectively. […] With no proven survival benefit for patients with a pre-clinically diagnosed relapse, the high costs and low positive predictive value make positron emission tomography/computed tomography unsuitable for routine surveillance of patients with Hodgkin lymphoma. […] The extensive use of routine surveillance imaging for HL patients remains controversial, with no international consensus.

• #61

  https://www.haematologica.org/article/view/6335

  The value of performing post-therapy routine surveillance imaging in patients with Hodgkin lymphoma is controversial. This study evaluates the utility of positron emission tomography/computed tomography using 2-[18F]fluoro-2-deoxyglucose for this purpose and in situations with suspected lymphoma relapse. […] The overall positive predictive value and negative predictive value of positron emission tomography/computed tomography were 28% and 100%, respectively. […] With no proven survival benefit for patients with a pre-clinically diagnosed relapse, the high costs and low positive predictive value make positron emission tomography/computed tomography unsuitable for routine surveillance of patients with Hodgkin lymphoma. […] The estimated cost per routine imaging diagnosed relapse was US$ 50,778.

• #62

  https://haematologica.org/article/view/6335

  The estimated price per routine PET/CT-diagnosed relapse was US$ 50,778 (21 PET/CT per relapse), but the price was reduced to US$ 21,762 if routine PET/CT surveillance had been restricted to patients with extranodal disease at presentation, PET-positive interim/mid-treatment scan and/or residual PET activity after completing treatment (9 PET/CT per relapse). […] The total costs of PET/CT surveillance are probably even higher because of the numerous supplementary investigations performed due to false positive PET/CT results. […] This study adds to the existing evidence in showing that PET/CT surveillance, both routine and clinically indicated, is associated with low PPV and that routine PET/CT surveillance has unacceptably high costs.

• #63 Factors Linked to Improved Survival in Hodgkin Lymphoma

  https://consultqd.clevelandclinic.org/outcomes-in-hodgkin-lymphoma-are-improving-but-disparities-persist

  Improvements in survival from Hodgkin lymphoma (HL) are one of the greatest medical accomplishments of the past half-century with event-free and overall survival rates now exceeding 85% and 90%, respectively. […] Despite these achievements, racial, ethnic and age-related disparities in outcomes have persisted over time. […] Inferior HL outcomes are reported in non-Hispanic Black and Hispanic populations as compared to white populations and in AYAs as compared to children. […] Intermediaries associated with this outcome disparity include stage at presentation, receiving care at specialized cancer centers, receipt of multimodal therapy, and enrollment in a clinical treatment trial. […] Racial and ethnic disparities in relapse are mitigated by enrollment on clinical trial. However, survival disparities in post-relapse mortality persist in the trial setting.

• #64 Incidence, mortality, risk factors, and trends for Hodgkin lymphoma: a global data analysis

  https://pmc.ncbi.nlm.nih.gov/articles/PMC9097358/

  Hodgkin lymphoma is a lymphatic malignancy commonly found in cervical lymph nodes. This study evaluated the worldwide incidence, mortality, associated risk factors, and temporal trends of Hodgkin lymphoma by sex, age, and country. […] The Hodgkin lymphoma incidence and mortality were 0.98 and 0.26 per 100,000 in 2020. A higher incidence was observed in high-income countries, while higher mortality was found in low-income countries. Incidence and mortality were associated with GDP per capita, prevalence of smoking, obesity, and hypertension at the population level. Despite the decreasing mortality trend, there was an increasing incidence, especially among females, younger population, and subjects from Asian countries. […] There was an increasing trend in Hodgkin lymphoma incidence, especially among subjects who were female, younger population, and from Asian countries. Further studies are needed to investigate the reasons for these epidemiologic trends.

• #65 Incidence, mortality, risk factors, and trends for Hodgkin lymphoma: a global data analysis | Journal of Hematology & Oncology | Full Text

  https://jhoonline.biomedcentral.com/articles/10.1186/s13045-022-01281-9

  For the past decade, the overall Hodgkin lymphoma incidence rate has been increasing, especially among subjects who were female, younger population, and from Asian countries. The drivers for this trend remain unknown, but might be attributable to the increasing prevalence of lifestyle and metabolic risk factors as well as improvements in early diagnosis. The Hodgkin lymphoma mortality has been decreasing probably due to the early cancer diagnosis and advances in treatment. However, increasing Hodgkin lymphoma mortality rates were noted in Chile and Ireland. Further studies are needed to investigate the reasons for these epidemiologic trends and have a better understanding of the particular aetiology and prognosis of Hodgkin lymphoma.

• #66 Incidence, mortality, risk factors, and trends for Hodgkin lymphoma: a global data analysis

  https://pmc.ncbi.nlm.nih.gov/articles/PMC9097358/

  For the past decade, the overall Hodgkin lymphoma incidence rate has been increasing, especially among subjects who were female, younger population, and from Asian countries. The drivers for this trend remain unknown, but might be attributable to the increasing prevalence of lifestyle and metabolic risk factors as well as improvements in early diagnosis. The Hodgkin lymphoma mortality has been decreasing probably due to the early cancer diagnosis and advances in treatment. However, increasing Hodgkin lymphoma mortality rates were noted in Chile and Ireland. Further studies are needed to investigate the reasons for these epidemiologic trends and have a better understanding of the particular aetiology and prognosis of Hodgkin lymphoma.

• #67 Global patterns of Hodgkin lymphoma incidence and mortality in 2020 and a prediction of the future burden in 2040 – PubMed

  https://pubmed.ncbi.nlm.nih.gov/35080783/

  Our study examines global patterns of Hodgkin lymphoma (HL) in 2020 and predicts the future incidence and mortality burden in 2040 using IARC’s GLOBOCAN estimates of the number of new cases and deaths of HL in 185 countries. A total of 83 000 new cases of HL and 23 000 deaths from HL were estimated in 2020. […] Incidence rates varied markedly by world region, at least 10-fold in both sexes, with the highest incidence rates observed in Southern Europe. Mortality exhibited an inverse pattern compared to incidence, with rates elevated in Western Asia and Northern Africa. […] The number of HL incident cases is predicted to rise to around 107 000 cases (a 30% increase) by 2040 due to demographic changes, assuming global rates in 2020 remains unchanged. The findings provide a baseline and impetus for developing strategies that aim to reduce the burden of HL in future decades.

• #68 Hodgkin lymphoma statistics | Cancer Research UK

  https://www.cancerresearchuk.org/health-professional/cancer-statistics/statistics-by-cancer-type/hodgkin-lymphoma

  Hodgkin lymphoma incidence rates are projected to rise by 13% in the UK between 2023-2025 and 2038-2040. […] There could be around 2,900 new cases of Hodgkin lymphoma every year in the UK by 2038-2040, projections suggest. […] Hodgkin lymphoma is not among the 20 most common causes of cancer death in the UK, accounting for less than 1% of all cancer deaths (2017-2019). […] Mortality rates for Hodgkin lymphoma in the UK are highest in people aged 85 to 89 (2017-2019). […] Since the early 1970s, Hodgkin lymphoma mortality rates have decreased by around three-quarters (74%) in the UK. Rates in females have decreased by more than seven-tenths (72%), and rates in males have decreased by around three-quarters (74%) (2017-2019). […] Hodgkin lymphoma mortality rates are projected to fall by 9% in the UK between 2023-2025 and 2038-2040.

• #69 Incidence, mortality, risk factors, and trends for Hodgkin lymphoma: a global data analysis

  https://pmc.ncbi.nlm.nih.gov/articles/PMC9097358/

  For the past decade, the overall Hodgkin lymphoma incidence rate has been increasing, especially among subjects who were female, younger population, and from Asian countries. The drivers for this trend remain unknown, but might be attributable to the increasing prevalence of lifestyle and metabolic risk factors as well as improvements in early diagnosis. The Hodgkin lymphoma mortality has been decreasing probably due to the early cancer diagnosis and advances in treatment. However, increasing Hodgkin lymphoma mortality rates were noted in Chile and Ireland. Further studies are needed to investigate the reasons for these epidemiologic trends and have a better understanding of the particular aetiology and prognosis of Hodgkin lymphoma.

• #70 Incidence, mortality, risk factors, and trends for Hodgkin lymphoma: a global data analysis | Journal of Hematology & Oncology | Full Text

  https://jhoonline.biomedcentral.com/articles/10.1186/s13045-022-01281-9

  For the past decade, the overall Hodgkin lymphoma incidence rate has been increasing, especially among subjects who were female, younger population, and from Asian countries. The drivers for this trend remain unknown, but might be attributable to the increasing prevalence of lifestyle and metabolic risk factors as well as improvements in early diagnosis. The Hodgkin lymphoma mortality has been decreasing probably due to the early cancer diagnosis and advances in treatment. However, increasing Hodgkin lymphoma mortality rates were noted in Chile and Ireland. Further studies are needed to investigate the reasons for these epidemiologic trends and have a better understanding of the particular aetiology and prognosis of Hodgkin lymphoma.

• #71 Incidence, mortality, risk factors, and trends for Hodgkin lymphoma: a global data analysis

  https://pmc.ncbi.nlm.nih.gov/articles/PMC9097358/

  For the past decade, the overall Hodgkin lymphoma incidence rate has been increasing, especially among subjects who were female, younger population, and from Asian countries. The drivers for this trend remain unknown, but might be attributable to the increasing prevalence of lifestyle and metabolic risk factors as well as improvements in early diagnosis. The Hodgkin lymphoma mortality has been decreasing probably due to the early cancer diagnosis and advances in treatment. However, increasing Hodgkin lymphoma mortality rates were noted in Chile and Ireland. Further studies are needed to investigate the reasons for these epidemiologic trends and have a better understanding of the particular aetiology and prognosis of Hodgkin lymphoma.

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