Zespół porezekcyjny
Epidemiologia
Zespół porezekcyjny (dumping syndrome) jest istotnym powikłaniem pooperacyjnym górnego odcinka przewodu pokarmowego, występującym u 20-50% pacjentów po operacjach żołądka, z ciężkimi objawami u 1-5%. Częstość występowania zależy od rodzaju zabiegu: wagotomia pniowa z drenażem (6-14%), częściowa gastrektomia (14-20%), operacje bariatryczne typu Roux-en-Y i rękawowa resekcja żołądka (do 40%), a także ezofagektomia (do 50%). Wczesny zespół porezekcyjny dotyczy około 75% przypadków, a późny 25%. Czynniki ryzyka obejmują płeć żeńską, wiek 45-74 lata, rasę białą oraz specyficzne nawyki żywieniowe, takie jak spożywanie więcej niż jednego dużego posiłku dziennie i picie płynów podczas posiłków. Diagnostyka opiera się na historii klinicznej, modyfikowanym doustnym teście tolerancji glukozy (wzrost hematokrytu o 3% lub tętna o 10 uderzeń/min po 30 minutach, hipoglikemia <50 mg/dl), systemie punktacji Sigstad (>3,26), testach oddechowych z wodorem oraz scyntygrafii opróżniania żołądka.
Epidemiologia zespołu porezekcyjnego
Zespół porezekcyjny (dumping syndrome) jest częstym powikłaniem operacji górnego odcinka przewodu pokarmowego, dotykającym znaczący odsetek pacjentów. Według dostępnych danych, częstość występowania tego zespołu waha się w przedziale od 20% do 50% wszystkich pacjentów po operacjach żołądka 123. Należy jednak podkreślić, że tylko około 1-5% pacjentów doświadcza ciężkich, upośledzających funkcjonowanie objawów 4. Częstość występowania zespołu porezekcyjnego jest bezpośrednio związana z typem i zakresem przeprowadzonej operacji żołądka 56.
Występowanie w zależności od typu zabiegu
Częstość występowania zespołu porezekcyjnego różni się znacząco w zależności od rodzaju przeprowadzonego zabiegu chirurgicznego:
- Wagotomia pniowa z drenażem: 6-14% pacjentów 78
- Częściowa gastrektomia: 14-20% pacjentów 910
- Proksymalna wagotomia żołądkowa bez procedury drenażu: poniżej 2% pacjentów 1112
- Operacje bariatryczne typu Roux-en-Y (bypass żołądkowy): do 40% pacjentów 1314
- Rękawowa resekcja żołądka: do 40% pacjentów 1516
- Ezofagektomia: do 50% pacjentów 171819
Badania wykazały, że około 70% pacjentów po operacji bypass żołądkowego doświadcza różnego stopnia objawów zespołu porezekcyjnego 20, a do 40% pacjentów ma objawy 6-12 miesięcy po rękawowej resekcji żołądka 21.
Trendy epidemiologiczne
W ostatnich dekadach zaobserwowano istotne zmiany w epidemiologii zespołu porezekcyjnego. Początkowo, w drugiej połowie XX wieku, zanotowano spadek częstości występowania zespołów pogastrektomijnych. Wynikało to z 10-krotnego zmniejszenia liczby planowych operacji w chorobie wrzodowej trawiennej w ciągu ostatnich 20-30 lat 22. Ten trend rozpoczął się jeszcze przed wprowadzeniem antagonistów receptora histaminowego H2, ale leki te wraz z inhibitorami pompy protonowej przyspieszyły ten spadek 23. Dodatkowo, odkrycie roli Helicobacter pylori w patogenezie choroby wrzodowej i wprowadzenie skutecznej eradykacji jeszcze bardziej zmniejszyło potrzebę interwencji chirurgicznych 2425.
Jednak w ostatnich latach obserwuje się ponowny wzrost częstości występowania zespołu porezekcyjnego, co jest związane głównie z rosnącą liczbą operacji bariatrycznych przeprowadzanych w leczeniu otyłości oraz operacji żołądka i przełyku w leczeniu nowotworów 262728. Zgodnie z danymi Brazylijskiego Towarzystwa Chirurgii Bariatrycznej i Metabolicznej, zapotrzebowanie na zabiegi chirurgiczne w walce z otyłością rośnie o około 20% rocznie w Brazylii 29.
Wczesny i późny zespół porezekcyjny
Wczesny zespół porezekcyjny występuje częściej niż późny zespół porezekcyjny 3031. Według danych Narodowego Instytutu Cukrzycy i Chorób Układu Trawiennego i Nerek, około 75% osób z zespołem porezekcyjnym doświadcza wczesnego zespołu porezekcyjnego, a około 25% doświadcza późnego zespołu porezekcyjnego 3233.
Czynniki ryzyka i determinanty zespołu porezekcyjnego
Czynniki demograficzne
Istniejące badania wskazują na kilka czynników demograficznych związanych ze zwiększonym ryzykiem wystąpienia zespołu porezekcyjnego:
- Płeć: Kobiety mają większą szansę na zdiagnozowanie zespołu porezekcyjnego w porównaniu z mężczyznami 3435. W jednym z badań zidentyfikowano płeć jako jeden z głównych czynników związanych ze zwiększoną częstością występowania zespołu porezekcyjnego 36.
- Wiek: Osoby w wieku 45-74 lat są 2 razy bardziej narażone na zdiagnozowanie zespołu porezekcyjnego 37.
- Pochodzenie etniczne: Osoby rasy białej częściej są diagnozowane z zespołem porezekcyjnym 38. Częstość występowania zespołu porezekcyjnego jest wyższa w populacjach zachodnich niż we wschodniej Azji 39.
- Wykształcenie i dochód: Badania wykazały związek między poziomem wykształcenia i miesięcznym dochodem a częstością występowania zespołu porezekcyjnego 40.
Nawyki żywieniowe i czynniki behawioralne
Nawyki żywieniowe po operacji bariatrycznej mają znaczący wpływ na rozwój zespołu porezekcyjnego. Badania wykazały, że następujące czynniki są związane ze zwiększonym ryzykiem:
- Spożywanie więcej niż jednego dużego posiłku dziennie 4142
- Picie płynów podczas posiłków – częstość występowania zespołu porezekcyjnego była znacząco wyższa u pacjentów, którzy pili płyny podczas posiłków w porównaniu do tych, którzy pili między posiłkami 43
- Spożywanie określonych rodzajów pokarmów, takich jak rafinowane cukry, produkty mleczne i niektóre smażone potrawy 44
Czynniki medyczne i chirurgiczne
Zespół porezekcyjny może wystąpić również u pacjentów, którzy nie przeszli operacji bariatrycznej. Osoby z cukrzycą, wagotomią, zewnątrzwydzielniczą niewydolnością trzustki, wrzodem dwunastnicy, zespołem Zollingera-Ellisona lub rozległą naprawą górnego odcinka przewodu pokarmowego mogą czasami rozwinąć zespół porezekcyjny 45.
Badania przeprowadzone na pacjentach bez historii operacji żołądka wykazały, że cukrzyca była najczęstszym czynnikiem etiologicznym zespołu porezekcyjnego 46. Wśród innych czynników ryzyka dla idiopatycznego zespołu porezekcyjnego wymienia się zaburzenia motoryki żołądka, słabe testy sytości po obciążeniu wodą oraz dysrytmie żołądkowe 47.
Nadzór i diagnostyka zespołu porezekcyjnego
Metody diagnostyczne
Diagnostyka zespołu porezekcyjnego jest złożona ze względu na nakładające się objawy z innymi schorzeniami medycznymi 48. Obecnie stosuje się kilka metod diagnostycznych:
- Ocena na podstawie historii medycznej pacjenta i obserwowanych objawów 4950
- Modyfikowany doustny test tolerancji glukozy – jest użyteczny do diagnostyki, a wzrost hematokrytu o 3% lub częstości tętna o 10 uderzeń/min 30 minut po rozpoczęciu spożycia glukozy jest diagnostyczny dla wczesnego zespołu porezekcyjnego, a poziom hipoglikemii nadir 50 mg/dl jest diagnostyczny dla późnego zespołu porezekcyjnego 5152
- Diagnostyka oparta na zmodyfikowanym systemie punktacji Sigstad dla zespołu porezekcyjnego (wartość progowa 3,26) 53
- Testy oddechowe z wodorem – mają 100% czułości i 92% swoistości w przypadkach wątpliwej diagnozy zespołu porezekcyjnego 54
- Scyntygraficzne (z wykorzystaniem znaczników radioaktywnych) badania opróżniania żołądka – są pomocne, szczególnie jeśli stan jest związany z problemem niezwiązanym z operacją (np. cukrzycą) 5556
- Ocena górnego odcinka przewodu pokarmowego – jest niezbędna do potwierdzenia późnego zespołu porezekcyjnego, ponieważ istnieją inne schorzenia, które mogą wywoływać podobne objawy 57
Badania kliniczne i nadzór
Obecnie prowadzone są badania kliniczne dotyczące zespołu porezekcyjnego. Według danych z ClinicalTrials.gov, istnieje co najmniej 15 badań klinicznych, w tym 2 aktywne, 8 zakończonych i 1 rekrutujące pacjentów 58. Regularne monitorowanie i kontrola są kluczowe dla skutecznego zarządzania zespołem porezekcyjnym 59.
Wyniki badań sugerują, że częstość występowania zespołu porezekcyjnego była wyższa w badaniach opublikowanych w 2000 roku lub później niż we wcześniejszych badaniach 60. Częstość występowania była również wyższa w badaniach wykorzystujących specjalistyczne kwestionariusze do pomiaru zespołu porezekcyjnego, co zmniejszało heterogeniczność między badaniami 61.
Potrzebne są dalsze, dobrze zaprojektowane badania, aby zidentyfikować czynniki ryzyka zespołu porezekcyjnego po operacji raka przełyku, zbadać fizyczne i funkcjonalne przyczyny zespołu porezekcyjnego oraz ocenić strategie zapobiegania jego występowaniu i poprawy zarządzania zespołem porezekcyjnym 62.
Wpływ zespołu porezekcyjnego na jakość życia
Zespół porezekcyjny może mieć znaczący wpływ na jakość życia pacjentów. Objawy zespołu porezekcyjnego są często wyniszczające i emocjonalnie stresujące, wiążą się ze znacznym obniżeniem jakości życia i mogą prowadzić do znacznej utraty wagi w wyniku unikania spożywania pokarmu przez pacjenta 63. Symptomy mogą powodować znaczną chorobowość 64.
Konsekwencje zespołu porezekcyjnego są istotne w kontekście zdrowotnym i społecznym. Zwiększająca się liczba pacjentów poddawanych operacjom bariatrycznym prowadzi do rosnącej liczby pacjentów z powikłaniami żołądkowo-jelitowymi 65. Ważne jest zatem, aby kierować działania mające na celu uświadomienie populacji o trudnościach, na które są narażeni, w tym o zespole porezekcyjnym 66.
Podsumowanie epidemiologii zespołu porezekcyjnego
Zespół porezekcyjny jest częstym powikłaniem występującym po operacjach żołądka, przełyku i bariatrycznych, dotykającym 20-50% pacjentów po operacjach żołądka 6768. Częstość występowania i nasilenie objawów zależą od rodzaju i zakresu operacji, a także od zastosowanych kryteriów diagnostycznych 6970.
Chociaż w przeszłości zaobserwowano spadek częstości występowania zespołu porezekcyjnego dzięki postępom w farmakoterapii chorób wrzodowych, obecnie obserwuje się ponowny wzrost, głównie z powodu rosnącej liczby operacji bariatrycznych i operacji związanych z leczeniem nowotworów żołądka i przełyku 7172.
Szereg czynników demograficznych, żywieniowych i medycznych wpływa na ryzyko rozwoju zespołu porezekcyjnego. Diagnostyka tego zespołu wymaga kompleksowego podejścia, uwzględniającego historię medyczną pacjenta, objawy kliniczne oraz specjalistyczne testy diagnostyczne 7374.
Skuteczne monitorowanie i nadzór nad pacjentami z grup ryzyka, a także wczesna diagnostyka i interwencja, są kluczowe dla minimalizacji wpływu zespołu porezekcyjnego na jakość życia pacjentów 7576.
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Materiały źródłowe
- #1 Dumping Syndrome – StatPearls – NCBI Bookshelfhttps://www.ncbi.nlm.nih.gov/books/NBK470542/
In patients who have undergone gastric surgery, an estimated 20% to 50% of patients have symptoms of Dumping syndrome. Patients develop severe symptoms approximately at a rate of 1 to 5%. Early Dumping syndrome appears to have a higher incidence compared to late Dumping syndrome. […] Most cases of dumping syndrome are successfully treated with dietary adjustments.
- #2 Dumping Syndrome: Background, Pathophysiology, Etiologyhttps://emedicine.medscape.com/article/173594-overview
The global incidence and severity of symptoms in dumping syndrome are related directly to the extent of gastric surgery. […] An estimated 20-50% of all patients who have undergone gastric surgery have some symptoms of dumping. […] However, only 1-5% are reported to have severe disabling symptoms. […] The incidence of significant dumping has been reported to be 6-14% in patients after truncal vagotomy and drainage and from 14-20% after partial gastrectomy. […] The incidence of dumping syndrome after proximal gastric vagotomy without any drainage procedure is less than 2%. […] Newer gastric operations, such as proximal gastric vagotomy (which produces minimal disturbance of gastric emptying mechanisms), are associated with a much lower incidence of postgastrectomy syndromes. […] In the pediatric population, dumping syndrome is described almost exclusively in children who have undergone Nissen fundoplication.
- #3 Dumping Syndrome: Diagnosis, Treatment, Symptoms & Causeshttps://my.clevelandclinic.org/health/diseases/17835-dumping-syndrome
Dumping syndrome most commonly happens as a complication of surgery on your stomach, or on your esophagus where it connects to your stomach. An estimated 20% to 50% of people who have had stomach surgery develop some symptoms of dumping syndrome. It’s most common in people who have had surgeries that remove or bypass large portions of the stomach, such as gastrectomy or gastric bypass surgery. […] Dumping syndrome is one of the most common post-gastrectomy syndromes that affect people recovering from surgery. There’s a good chance you may experience some symptoms immediately following your procedure. Fortunately, most cases are mild and go away on their own in a few weeks to months.
- #4 Dumping Syndrome: Background, Pathophysiology, Etiologyhttps://emedicine.medscape.com/article/173594-overview
The global incidence and severity of symptoms in dumping syndrome are related directly to the extent of gastric surgery. […] An estimated 20-50% of all patients who have undergone gastric surgery have some symptoms of dumping. […] However, only 1-5% are reported to have severe disabling symptoms. […] The incidence of significant dumping has been reported to be 6-14% in patients after truncal vagotomy and drainage and from 14-20% after partial gastrectomy. […] The incidence of dumping syndrome after proximal gastric vagotomy without any drainage procedure is less than 2%. […] Newer gastric operations, such as proximal gastric vagotomy (which produces minimal disturbance of gastric emptying mechanisms), are associated with a much lower incidence of postgastrectomy syndromes. […] In the pediatric population, dumping syndrome is described almost exclusively in children who have undergone Nissen fundoplication.
- #5 Dumping Syndrome: Background, Pathophysiology, Etiologyhttps://emedicine.medscape.com/article/173594-overview
The global incidence and severity of symptoms in dumping syndrome are related directly to the extent of gastric surgery. […] An estimated 20-50% of all patients who have undergone gastric surgery have some symptoms of dumping. […] However, only 1-5% are reported to have severe disabling symptoms. […] The incidence of significant dumping has been reported to be 6-14% in patients after truncal vagotomy and drainage and from 14-20% after partial gastrectomy. […] The incidence of dumping syndrome after proximal gastric vagotomy without any drainage procedure is less than 2%. […] Newer gastric operations, such as proximal gastric vagotomy (which produces minimal disturbance of gastric emptying mechanisms), are associated with a much lower incidence of postgastrectomy syndromes. […] In the pediatric population, dumping syndrome is described almost exclusively in children who have undergone Nissen fundoplication.
- #6 Dumping Syndrome | Treatment & Management | Point of Carehttps://www.statpearls.com/point-of-care/20752
In patients who have undergone gastric surgery, an estimated 20% to 50% of patients have symptoms of Dumping syndrome. Patients develop severe symptoms approximately at a rate of 1 to 5%. Early Dumping syndrome appears to have a higher incidence compared to late Dumping syndrome. […] The severity of dumping syndrome is correlated to the extent of gastric surgery.
- #7 Dumping Syndrome: Background, Pathophysiology, Etiologyhttps://emedicine.medscape.com/article/173594-overview
The global incidence and severity of symptoms in dumping syndrome are related directly to the extent of gastric surgery. […] An estimated 20-50% of all patients who have undergone gastric surgery have some symptoms of dumping. […] However, only 1-5% are reported to have severe disabling symptoms. […] The incidence of significant dumping has been reported to be 6-14% in patients after truncal vagotomy and drainage and from 14-20% after partial gastrectomy. […] The incidence of dumping syndrome after proximal gastric vagotomy without any drainage procedure is less than 2%. […] Newer gastric operations, such as proximal gastric vagotomy (which produces minimal disturbance of gastric emptying mechanisms), are associated with a much lower incidence of postgastrectomy syndromes. […] In the pediatric population, dumping syndrome is described almost exclusively in children who have undergone Nissen fundoplication.
- #8 Dumping Syndrome | 5-Minute Clinical Consulthttps://www.unboundmedicine.com/5minute/view/5-Minute-Clinical-Consult/816042/all/Dumping_Syndrome
Overall, ~10% of patients following gastric surgery and up to 50% of patients who undergo esophagectomy develop dumping symptoms. […] In the United States, ~1% of patients undergoing proximal gastric vagotomy without any drainage procedure; 10-22% truncal vagotomy and drainage experience dumping syndrome. […] After partial gastrectomy, 14-20% of patients develop symptoms of dumping. […] 70% of gastric bypass patients experience varying degrees of dumping symptoms. […] Up to 40% of patients have dumping symptoms 6 to 12 months after sleeve gastrectomy.
- #9 Dumping Syndrome: Background, Pathophysiology, Etiologyhttps://emedicine.medscape.com/article/173594-overview
The global incidence and severity of symptoms in dumping syndrome are related directly to the extent of gastric surgery. […] An estimated 20-50% of all patients who have undergone gastric surgery have some symptoms of dumping. […] However, only 1-5% are reported to have severe disabling symptoms. […] The incidence of significant dumping has been reported to be 6-14% in patients after truncal vagotomy and drainage and from 14-20% after partial gastrectomy. […] The incidence of dumping syndrome after proximal gastric vagotomy without any drainage procedure is less than 2%. […] Newer gastric operations, such as proximal gastric vagotomy (which produces minimal disturbance of gastric emptying mechanisms), are associated with a much lower incidence of postgastrectomy syndromes. […] In the pediatric population, dumping syndrome is described almost exclusively in children who have undergone Nissen fundoplication.
- #10 Dumping Syndrome | 5-Minute Clinical Consulthttps://www.unboundmedicine.com/5minute/view/5-Minute-Clinical-Consult/816042/all/Dumping_Syndrome
Overall, ~10% of patients following gastric surgery and up to 50% of patients who undergo esophagectomy develop dumping symptoms. […] In the United States, ~1% of patients undergoing proximal gastric vagotomy without any drainage procedure; 10-22% truncal vagotomy and drainage experience dumping syndrome. […] After partial gastrectomy, 14-20% of patients develop symptoms of dumping. […] 70% of gastric bypass patients experience varying degrees of dumping symptoms. […] Up to 40% of patients have dumping symptoms 6 to 12 months after sleeve gastrectomy.
- #11 Dumping Syndrome: Background, Pathophysiology, Etiologyhttps://emedicine.medscape.com/article/173594-overview
The global incidence and severity of symptoms in dumping syndrome are related directly to the extent of gastric surgery. […] An estimated 20-50% of all patients who have undergone gastric surgery have some symptoms of dumping. […] However, only 1-5% are reported to have severe disabling symptoms. […] The incidence of significant dumping has been reported to be 6-14% in patients after truncal vagotomy and drainage and from 14-20% after partial gastrectomy. […] The incidence of dumping syndrome after proximal gastric vagotomy without any drainage procedure is less than 2%. […] Newer gastric operations, such as proximal gastric vagotomy (which produces minimal disturbance of gastric emptying mechanisms), are associated with a much lower incidence of postgastrectomy syndromes. […] In the pediatric population, dumping syndrome is described almost exclusively in children who have undergone Nissen fundoplication.
- #12 Dumping Syndrome | 5-Minute Clinical Consulthttps://www.unboundmedicine.com/5minute/view/5-Minute-Clinical-Consult/816042/all/Dumping_Syndrome
Overall, ~10% of patients following gastric surgery and up to 50% of patients who undergo esophagectomy develop dumping symptoms. […] In the United States, ~1% of patients undergoing proximal gastric vagotomy without any drainage procedure; 10-22% truncal vagotomy and drainage experience dumping syndrome. […] After partial gastrectomy, 14-20% of patients develop symptoms of dumping. […] 70% of gastric bypass patients experience varying degrees of dumping symptoms. […] Up to 40% of patients have dumping symptoms 6 to 12 months after sleeve gastrectomy.
- #13 International consensus on the diagnosis and management of dumping syndrome | Nature Reviews Endocrinologyhttps://www.nature.com/articles/s41574-020-0357-5
Dumping syndrome is a common but underdiagnosed complication of gastric and oesophageal surgery. […] The prevalence of dumping syndrome depends on the type and extent of surgery, and on the criteria used to diagnose dumping syndrome. Dumping syndrome occurs in approximately 20% of patients undergoing vagotomy with pyloroplasty, in up to 40% of patients after Roux-en-Y gastric bypass (RYGB) or sleeve gastrectomy and in up to 50% of patients undergoing oesophagectomy. […] According to reports published in the past 15 years, bariatric surgery has become the main cause of postoperative dumping syndrome. […] Symptoms of dumping syndrome are often debilitating and emotionally distressing, they are associated with a substantial reduction in quality of life and might lead to considerable weight loss as a result of the patient avoiding food intake.
- #14 Dumping syndrome | Radiology Reference Article | Radiopaedia.orghttps://radiopaedia.org/articles/dumping-syndrome?embed_domain=hackmd.io%2F%40yIPUAFeCSL2JsU8smR5nJQ%2Fbnjhjgjghjghjgh&lang=us
Dumping syndrome occurs in approximately 12-40% of patients following Roux-en-Y gastric bypass, and up to 50% of patients following esophagectomy 1,2. […] Most cases of dumping syndrome are the early dumping syndrome type 1,2.
- #15 International consensus on the diagnosis and management of dumping syndrome | Nature Reviews Endocrinologyhttps://www.nature.com/articles/s41574-020-0357-5
Dumping syndrome is a common but underdiagnosed complication of gastric and oesophageal surgery. […] The prevalence of dumping syndrome depends on the type and extent of surgery, and on the criteria used to diagnose dumping syndrome. Dumping syndrome occurs in approximately 20% of patients undergoing vagotomy with pyloroplasty, in up to 40% of patients after Roux-en-Y gastric bypass (RYGB) or sleeve gastrectomy and in up to 50% of patients undergoing oesophagectomy. […] According to reports published in the past 15 years, bariatric surgery has become the main cause of postoperative dumping syndrome. […] Symptoms of dumping syndrome are often debilitating and emotionally distressing, they are associated with a substantial reduction in quality of life and might lead to considerable weight loss as a result of the patient avoiding food intake.
- #16 Dumping Syndrome | 5-Minute Clinical Consulthttps://www.unboundmedicine.com/5minute/view/5-Minute-Clinical-Consult/816042/all/Dumping_Syndrome
Overall, ~10% of patients following gastric surgery and up to 50% of patients who undergo esophagectomy develop dumping symptoms. […] In the United States, ~1% of patients undergoing proximal gastric vagotomy without any drainage procedure; 10-22% truncal vagotomy and drainage experience dumping syndrome. […] After partial gastrectomy, 14-20% of patients develop symptoms of dumping. […] 70% of gastric bypass patients experience varying degrees of dumping symptoms. […] Up to 40% of patients have dumping symptoms 6 to 12 months after sleeve gastrectomy.
- #17 International consensus on the diagnosis and management of dumping syndrome | Nature Reviews Endocrinologyhttps://www.nature.com/articles/s41574-020-0357-5
Dumping syndrome is a common but underdiagnosed complication of gastric and oesophageal surgery. […] The prevalence of dumping syndrome depends on the type and extent of surgery, and on the criteria used to diagnose dumping syndrome. Dumping syndrome occurs in approximately 20% of patients undergoing vagotomy with pyloroplasty, in up to 40% of patients after Roux-en-Y gastric bypass (RYGB) or sleeve gastrectomy and in up to 50% of patients undergoing oesophagectomy. […] According to reports published in the past 15 years, bariatric surgery has become the main cause of postoperative dumping syndrome. […] Symptoms of dumping syndrome are often debilitating and emotionally distressing, they are associated with a substantial reduction in quality of life and might lead to considerable weight loss as a result of the patient avoiding food intake.
- #18 Dumping syndrome | Radiology Reference Article | Radiopaedia.orghttps://radiopaedia.org/articles/dumping-syndrome?embed_domain=hackmd.io%2F%40yIPUAFeCSL2JsU8smR5nJQ%2Fbnjhjgjghjghjgh&lang=us
Dumping syndrome occurs in approximately 12-40% of patients following Roux-en-Y gastric bypass, and up to 50% of patients following esophagectomy 1,2. […] Most cases of dumping syndrome are the early dumping syndrome type 1,2.
- #19 Dumping Syndrome | CEGhttps://www.dovepress.com/dumping-syndrome-pragmatic-treatment-options-and-experimental-approach-peer-reviewed-fulltext-article-CEG
The reported incidence and prevalence of dumping syndrome varies widely and depends on (1) which definition and diagnostic criteria are used, and (2) the type and extent of surgery performed. It is estimated that dumping symptoms are present in around 20% of patients with vagotomy with pyloroplasty, up to 40% of patients after RYGB or sleeve gastrectomy, and have been reported in up to 50% of patients after esophagectomy. […] As a larger number of patients are undergoing sleeve gastrectomy or RYGB for bariatric purposes, it is important for clinicians to recognize and treat dumping syndrome as it results in a reduced health-related quality of life for patients. […] In general, the prevalence of dumping symptoms is increasing over time as more upper gastrointestinal (GI) and bariatric surgical procedures are being performed. One should consider that patients have often changed eating patterns to reduce dumping symptoms prior to seeking medical advice. This hampers interpretation of the above-mentioned studies and estimates, as provocative testing is not uniformly or routinely performed.
- #20 Dumping Syndrome | 5-Minute Clinical Consulthttps://www.unboundmedicine.com/5minute/view/5-Minute-Clinical-Consult/816042/all/Dumping_Syndrome
Overall, ~10% of patients following gastric surgery and up to 50% of patients who undergo esophagectomy develop dumping symptoms. […] In the United States, ~1% of patients undergoing proximal gastric vagotomy without any drainage procedure; 10-22% truncal vagotomy and drainage experience dumping syndrome. […] After partial gastrectomy, 14-20% of patients develop symptoms of dumping. […] 70% of gastric bypass patients experience varying degrees of dumping symptoms. […] Up to 40% of patients have dumping symptoms 6 to 12 months after sleeve gastrectomy.
- #21 Dumping Syndrome | 5-Minute Clinical Consulthttps://www.unboundmedicine.com/5minute/view/5-Minute-Clinical-Consult/816042/all/Dumping_Syndrome
Overall, ~10% of patients following gastric surgery and up to 50% of patients who undergo esophagectomy develop dumping symptoms. […] In the United States, ~1% of patients undergoing proximal gastric vagotomy without any drainage procedure; 10-22% truncal vagotomy and drainage experience dumping syndrome. […] After partial gastrectomy, 14-20% of patients develop symptoms of dumping. […] 70% of gastric bypass patients experience varying degrees of dumping symptoms. […] Up to 40% of patients have dumping symptoms 6 to 12 months after sleeve gastrectomy.
- #22 Dumping Syndrome: Background, Pathophysiology, Etiologyhttps://emedicine.medscape.com/article/173594-overview
Reductions in the need for elective gastric surgery have led to a decline in the frequency of postgastrectomy syndromes. […] A 10-fold reduction has occurred in elective operations for peptic ulcer disease in the last 20-30 years. […] Although this trend preceded the advent of histamine-2 receptor antagonists, these drugs and proton pump inhibitors have accelerated the decline. […] Helicobacter pylori treatment and eradication in patients with peptic ulcer disease have further decreased the need for surgery. […] Although the need for elective surgery for peptic ulcer disease has declined, the need for emergency surgery has remained the same over the last 20 years. […] Emergency surgery tends to be more mutilating to the stomach. […] This increases the incidence of more severe symptoms.
- #23 Dumping Syndrome: Background, Pathophysiology, Etiologyhttps://emedicine.medscape.com/article/173594-overview
Reductions in the need for elective gastric surgery have led to a decline in the frequency of postgastrectomy syndromes. […] A 10-fold reduction has occurred in elective operations for peptic ulcer disease in the last 20-30 years. […] Although this trend preceded the advent of histamine-2 receptor antagonists, these drugs and proton pump inhibitors have accelerated the decline. […] Helicobacter pylori treatment and eradication in patients with peptic ulcer disease have further decreased the need for surgery. […] Although the need for elective surgery for peptic ulcer disease has declined, the need for emergency surgery has remained the same over the last 20 years. […] Emergency surgery tends to be more mutilating to the stomach. […] This increases the incidence of more severe symptoms.
- #24 Dumping Syndrome: Background, Pathophysiology, Etiologyhttps://emedicine.medscape.com/article/173594-overview
Reductions in the need for elective gastric surgery have led to a decline in the frequency of postgastrectomy syndromes. […] A 10-fold reduction has occurred in elective operations for peptic ulcer disease in the last 20-30 years. […] Although this trend preceded the advent of histamine-2 receptor antagonists, these drugs and proton pump inhibitors have accelerated the decline. […] Helicobacter pylori treatment and eradication in patients with peptic ulcer disease have further decreased the need for surgery. […] Although the need for elective surgery for peptic ulcer disease has declined, the need for emergency surgery has remained the same over the last 20 years. […] Emergency surgery tends to be more mutilating to the stomach. […] This increases the incidence of more severe symptoms.
- #25 Dumping syndrome: Causes, management, and patient educationhttps://www.myamericannurse.com/dumping-syndrome/
Dumping syndrome (DS), a well-established yet under-recognized side effect of upper GI surgery, occurs when the body reacts to food moving too rapidly from the stomach into the intestine, resulting in unpleasant symptoms such as a pounding pulse, sweating, dizziness, and nausea. […] DS occurs after 20% to 75% of all esophageal and gastric surgeries. Its incidence decreased during the 20th century when the discovery of Helicobacter pylori made most gastric surgical interventions to treat chronic gastritis and peptic ulcer disease unnecessary and treatment shifted to medication. But the recent increase in bariatric surgery and gastric or esophageal surgery to treat cancer has led to an increase in the incidence of DS. […] Many people who have undergone upper GI surgery aren’t aware of DS and haven’t been adequately educated about it. In addition, DS symptoms frequently are misdiagnosed. Nurses and other healthcare providers should understand the etiology, symptoms, and management of DS to educate patients and to improve their health outcomes and quality of life.
- #26 International consensus on the diagnosis and management of dumping syndrome | Nature Reviews Endocrinologyhttps://www.nature.com/articles/s41574-020-0357-5
Dumping syndrome is a common but underdiagnosed complication of gastric and oesophageal surgery. […] The prevalence of dumping syndrome depends on the type and extent of surgery, and on the criteria used to diagnose dumping syndrome. Dumping syndrome occurs in approximately 20% of patients undergoing vagotomy with pyloroplasty, in up to 40% of patients after Roux-en-Y gastric bypass (RYGB) or sleeve gastrectomy and in up to 50% of patients undergoing oesophagectomy. […] According to reports published in the past 15 years, bariatric surgery has become the main cause of postoperative dumping syndrome. […] Symptoms of dumping syndrome are often debilitating and emotionally distressing, they are associated with a substantial reduction in quality of life and might lead to considerable weight loss as a result of the patient avoiding food intake.
- #27 Gastroparesis and Dumping Syndrome: Current Concepts and Managementhttps://www.mdpi.com/2077-0383/8/8/1127
Gastroparesis and dumping syndrome are frequent, but their prevalence and incidence vary depending on definitions and studied populations. Therefore, heterogenous results have been reported in the literature. […] The prevalence of gastroparesis in the general population is uncertain. A wide range in different at-risk populations has been reported. In addition, gastroparesis is likely significantly under diagnosed. […] Reliable population-based prevalence data for dumping syndrome are still lacking. As of yet, the frequency of postsurgical dumping syndrome is estimated at 25%â50% with 5 to 10% of patients experiencing a severe disabling form. […] The incidence and prevalence of dumping syndrome has been increasing due to the current obesity epidemics and the consecutive climb in gastric bypass surgeries.
- #28 Dumping syndrome: Causes, management, and patient educationhttps://www.myamericannurse.com/dumping-syndrome/
Dumping syndrome (DS), a well-established yet under-recognized side effect of upper GI surgery, occurs when the body reacts to food moving too rapidly from the stomach into the intestine, resulting in unpleasant symptoms such as a pounding pulse, sweating, dizziness, and nausea. […] DS occurs after 20% to 75% of all esophageal and gastric surgeries. Its incidence decreased during the 20th century when the discovery of Helicobacter pylori made most gastric surgical interventions to treat chronic gastritis and peptic ulcer disease unnecessary and treatment shifted to medication. But the recent increase in bariatric surgery and gastric or esophageal surgery to treat cancer has led to an increase in the incidence of DS. […] Many people who have undergone upper GI surgery aren’t aware of DS and haven’t been adequately educated about it. In addition, DS symptoms frequently are misdiagnosed. Nurses and other healthcare providers should understand the etiology, symptoms, and management of DS to educate patients and to improve their health outcomes and quality of life.
- #29 SciELO Brazil – PATHOPHYSIOLOGY, DIAGNOSIS AND TREATMENTOF DUMPING SYNDROME AND ITS RELATION TO BARIATRIC SURGERY PATHOPHYSIOLOGY, DIAGNOSIS AND TREATMENTOF DUMPING SYNDROME AND ITS RELATION TO BARIATRIC SURGERYhttps://www.scielo.br/j/abcd/a/c85MgtFzcsLqhYTrrWNpHvM/
The Brazilian Society of Bariatric and Metabolic Surgery claims that the demand for surgical procedures to combat obesity is growing about 20% per year in Brazil; so, it is important to direct actions aiming to aware the population about the hardships to which they are exposed, where dumping syndrome is included.
- #30 Dumping Syndrome | Treatment & Management | Point of Carehttps://www.statpearls.com/point-of-care/20752
In patients who have undergone gastric surgery, an estimated 20% to 50% of patients have symptoms of Dumping syndrome. Patients develop severe symptoms approximately at a rate of 1 to 5%. Early Dumping syndrome appears to have a higher incidence compared to late Dumping syndrome. […] The severity of dumping syndrome is correlated to the extent of gastric surgery.
- #31 Dumping Syndrome – StatPearls – NCBI Bookshelfhttps://www.ncbi.nlm.nih.gov/books/NBK470542/
In patients who have undergone gastric surgery, an estimated 20% to 50% of patients have symptoms of Dumping syndrome. Patients develop severe symptoms approximately at a rate of 1 to 5%. Early Dumping syndrome appears to have a higher incidence compared to late Dumping syndrome. […] Most cases of dumping syndrome are successfully treated with dietary adjustments.
- #32 Dumping syndrome: Symptoms, causes, and phaseshttps://www.medicalnewstoday.com/articles/320479
Dumping syndrome, also called rapid gastric emptying, occurs when food moves too quickly from the stomach into the first section of the small intestine, known as the duodenum. […] The condition most commonly occurs in people who have undergone gastric surgery. […] According to the National Institute of Diabetes and Digestive and Kidney Diseases, approximately 75 percent of people with dumping syndrome experience early dumping syndrome, and around 25 percent experience late dumping syndrome. […] The most common cause of dumping syndrome is surgery, with the condition arising in at least 15 percent of people who have part of their stomach removed. […] Some people may not develop dumping syndrome until years after surgery. […] Dumping syndrome is a common complication of gastric surgeries.
- #33 Dumping Syndrome: Symptoms, Causes, and Treatmenthttps://www.verywellhealth.com/what-to-do-for-dumping-syndrome-1945209
Dumping syndrome is most often seen in people who have had bariatric (weight loss), esophageal, or gastric surgery. […] Estimates of the number of people who experience dumping syndrome following gastric surgery range from 20% to 50%. […] The type of surgery you have also influences your risk of developing dumping syndrome. […] Most people with dumping syndrome experience the early form, while only about a quarter experiences the late-type. […] Late dumping syndrome results more exclusively from changes in blood glucose and insulin levels. […] In late dumping syndrome, symptoms are triggered because too much sugar is released into the small intestine too quickly. […] Dumping syndrome is diagnosed based on your medical history and symptoms. […] Your practitioner will evaluate you and advise you as to the best course of action.
- #34 Gastric dumping syndrome epidemiology and demographics – wikidochttps://www.wikidoc.org/index.php/Gastric_dumping_syndrome_epidemiology_and_demographics
In esophagectomy 1 out of 2 people developed symptoms of dumping syndrome. […] Prevalence has not been well studied in gastric dumping syndrome. […] In 2012, the mortality rate of bariatric surgery leading to dumping syndrome was approximately 1,000 per 100,000 individuals. […] People aged 45-74 are 2 times more likely to be diagnosed with dumping syndrome. […] Females have a higher chance of being diagnosed with dumping syndrome in comparison to men. […] People who are of white ethnicity tend to be more likely diagnosed with dumping syndrome.
- #35 Dumping Syndrome: Background, Pathophysiology, Etiologyhttps://emedicine.medscape.com/article/173594-overview
Gastric surgery is also performed as part of the care of persons with a gastric malignancy, or as an approach to weight loss (bariatric surgery). […] Bariatric surgery is the only satisfactory long-term treatment for severe obesity (body mass index [BMI] 40 kg/m or greater, or 35 kg/m or greater with severe obesity-associated comorbidities, such as diabetes, obstructive sleep apnea, or debilitating degenerative arthritis). […] Even in specialized units, the mortality rate of bariatric surgery may be 1%, and serious complications may occur in about 10% of cases. […] Some 80% of the deaths that occur within a month of bariatric surgery arise from anastomotic leaks, pulmonary emboli, and respiratory failure. […] A female preponderance exists in the incidence of postgastrectomy syndromes.
- #36 Prevalence of Dumping Syndrome and Its Determinants Among Post-Bariatric Surgery Adult Patients at King Fahad General Hospital, Jeddah, 2019â2020https://pmc.ncbi.nlm.nih.gov/articles/PMC9841919/
In this single institutional study, we report a 31.4% prevalence of DS among our cohort. The predictors of the syndrome include gender, education level, monthly income, eating more than one large meal per day, and drinking liquids with meals. […] The current study revealed five main factors associated with the increased prevalence of DS; three factors related to the demographic characteristics of patients and two factors related to dietary habits after bariatric surgery and the degree of compliance of the patients with the instructions and recommendations related to dietary adjustment. […] The fifth factor associated with DS identified in the current study was drinking liquids with meals; the prevalence of DS was found significantly higher in patients who drank liquids with meals compared to those who drank between meals.
- #37 Gastric dumping syndrome epidemiology and demographics – wikidochttps://www.wikidoc.org/index.php/Gastric_dumping_syndrome_epidemiology_and_demographics
In esophagectomy 1 out of 2 people developed symptoms of dumping syndrome. […] Prevalence has not been well studied in gastric dumping syndrome. […] In 2012, the mortality rate of bariatric surgery leading to dumping syndrome was approximately 1,000 per 100,000 individuals. […] People aged 45-74 are 2 times more likely to be diagnosed with dumping syndrome. […] Females have a higher chance of being diagnosed with dumping syndrome in comparison to men. […] People who are of white ethnicity tend to be more likely diagnosed with dumping syndrome.
- #38 Gastric dumping syndrome epidemiology and demographics – wikidochttps://www.wikidoc.org/index.php/Gastric_dumping_syndrome_epidemiology_and_demographics
In esophagectomy 1 out of 2 people developed symptoms of dumping syndrome. […] Prevalence has not been well studied in gastric dumping syndrome. […] In 2012, the mortality rate of bariatric surgery leading to dumping syndrome was approximately 1,000 per 100,000 individuals. […] People aged 45-74 are 2 times more likely to be diagnosed with dumping syndrome. […] Females have a higher chance of being diagnosed with dumping syndrome in comparison to men. […] People who are of white ethnicity tend to be more likely diagnosed with dumping syndrome.
- #39https://link.springer.com/article/10.1245/s10434-024-15881-x
Dumping syndrome occurs frequently after esophageal cancer surgery, but the reported prevalence varied across previous studies. […] The prevalence of dumping syndrome ranged 0-74% in these studies, showing high heterogeneity (I2 = 99%, P 0.01), with the pooled prevalence of 27% (95% confidence interval [CI] 14-39%). […] Our findings revealed that dumping syndrome is common after esophageal cancer surgery. […] Previous studies have reported varying prevalence of dumping syndrome after esophageal cancer surgery. […] The pooled prevalence was higher in studies using specialized questionnaires for measuring dumping syndrome with reduced heterogeneity across studies. […] The prevalence of dumping syndrome also was higher in studies published in 2000 or later than in earlier studies, was higher in Western populations than in Eastern Asian populations, and varied by length and completeness of follow-up.
- #40 Prevalence of Dumping Syndrome and Its Determinants Among Post-Bariatric Surgery Adult Patients at King Fahad General Hospital, Jeddah, 2019â2020https://pmc.ncbi.nlm.nih.gov/articles/PMC9841919/
In this single institutional study, we report a 31.4% prevalence of DS among our cohort. The predictors of the syndrome include gender, education level, monthly income, eating more than one large meal per day, and drinking liquids with meals. […] The current study revealed five main factors associated with the increased prevalence of DS; three factors related to the demographic characteristics of patients and two factors related to dietary habits after bariatric surgery and the degree of compliance of the patients with the instructions and recommendations related to dietary adjustment. […] The fifth factor associated with DS identified in the current study was drinking liquids with meals; the prevalence of DS was found significantly higher in patients who drank liquids with meals compared to those who drank between meals.
- #41 Prevalence of Dumping Syndrome and Its Determinants Among Post-Bariatric Surgery Adult Patients at King Fahad General Hospital, Jeddah, 2019â2020https://pmc.ncbi.nlm.nih.gov/articles/PMC9841919/
In this single institutional study, we report a 31.4% prevalence of DS among our cohort. The predictors of the syndrome include gender, education level, monthly income, eating more than one large meal per day, and drinking liquids with meals. […] The current study revealed five main factors associated with the increased prevalence of DS; three factors related to the demographic characteristics of patients and two factors related to dietary habits after bariatric surgery and the degree of compliance of the patients with the instructions and recommendations related to dietary adjustment. […] The fifth factor associated with DS identified in the current study was drinking liquids with meals; the prevalence of DS was found significantly higher in patients who drank liquids with meals compared to those who drank between meals.
- #42 Prevalence of Dumping Syndrome and Its – ProQuesthttps://www.proquest.com/scholarly-journals/prevalence-dumping-syndrome-determinants-among/docview/2771235288/se-2
Obesity has been recognized by the World Health Organization (WHO) as one of the most significant health problems worldwide; its prevalence has been increasing over the past decades despite extensive preventative efforts. […] Dumping syndrome (DS) has been reported as a common consequence of bariatric surgery; a reviewed study pointed to prevalence rates ranging from 19% to 32% due to variations in the type of surgery, definition, and diagnostic test used. […] Based on the modified Sigstad diagnostic scoring system for DS, 75 participants (31.4%) met the criteria (threshold value of 3.26) to be categorized as DS patients. […] The current study aimed at exploring the prevalence of DS and associated factors in patients who have undergone bariatric surgery in one of the main general hospitals in Jeddah, Saudi Arabia. […] The predictors include eating more than one large meal per day and drinking liquids with meals.
- #43 Prevalence of Dumping Syndrome and Its Determinants Among Post-Bariatric Surgery Adult Patients at King Fahad General Hospital, Jeddah, 2019â2020https://pmc.ncbi.nlm.nih.gov/articles/PMC9841919/
In this single institutional study, we report a 31.4% prevalence of DS among our cohort. The predictors of the syndrome include gender, education level, monthly income, eating more than one large meal per day, and drinking liquids with meals. […] The current study revealed five main factors associated with the increased prevalence of DS; three factors related to the demographic characteristics of patients and two factors related to dietary habits after bariatric surgery and the degree of compliance of the patients with the instructions and recommendations related to dietary adjustment. […] The fifth factor associated with DS identified in the current study was drinking liquids with meals; the prevalence of DS was found significantly higher in patients who drank liquids with meals compared to those who drank between meals.
- #44 Dumping syndrome | Laparoscopic.MDhttps://www.laparoscopic.md/glossary/dumping-syndrome
Dumping syndrome usually occurs in individuals who had a gastric bypass surgery (Roux-en-Y surgery). […] Dumping syndrome is more likely to occur with ingestion of certain types of foods such as refined sugars, dairy products and certain fried foods.
- #45 Complications of Bariatric Surgery: Dumping Syndrome and Drug Dispositionhttps://www.pharmacytimes.com/view/complications-of-bariatric-surgery-dumping-syndrome-and-drug-disposition
Dumping syndrome is a side effect of malabsorptive bariatric procedures such as RYGB and biliopancreatic diversion. Approximately 40% of people who undergo bariatric surgery develop dumping syndrome, and most studies report that it does not increase or decrease weight loss. […] Dumping syndrome can also occur in patients who have not had bariatric surgery. People with diabetes, vagotomy, pancreatic exocrine insufficiency, duodenal ulcer, Zollinger-Ellison syndrome or extensive upper gastrointestinal repair sometimes develop dumping syndrome. […] Bariatric surgeons diagnose dumping syndrome based on the patientâs report of symptoms and observation of the patient after a carbohydrate-rich meal. Additionally, surgeons record postprandial serial pulse rate and hematocrit to screen for cardiovascular effects, and perform prolonged postprandial glucose testing to confirm reactive hypoglycemia. Scintigraphic (radioactive tracing) gastric emptying tests are also helpful, especially if the condition is related to a nonsurgical problem (eg, diabetes mellitus).
- #46 Dumping Syndrome: Updated Perspectives on Etiologies and Diagnosis – Practical Gastrohttps://practicalgastro.com/2014/10/18/dumping-syndrome-updated-perspectives-on-etiologies-and-diagnosis/
Among etiologic factors of DS in our patient group, DM was the most common. […] These findings emphasize a crucial role for scintigraphic GET in patients who have the symptoms of DS, even in the absence of a recent gastric surgery. This is essential to make the diagnosis of DS and effectively treat patients with this condition.
- #47https://journals.lww.com/ajg/fulltext/2018/10001/idiopathic_dumping_syndrome_in_patients_presenting.1185.aspx
Dumping syndrome is a wellknown complication after gastric surgery. However, limited literature exists on idiopathic dumping syndrome. […] Patients with severe idiopathic rapid gastric emptying may present with nausea and gastroparesislike symptoms rather than vasomotor symptoms and diarrhea typically seen in postsurgical dumping syndrome; […] Over half of the patients had risk factors for abnormal gastric motility, such as diabetes, poor water load satiety tests, and gastric dysrhythmias, which may contribute to altered emptying rates; […] Rapid gastric emptying should be considered in patients who present with chronic unexplained nausea without previous gastric surgeries.
- #48 Dumping Syndrome: Symptoms & Treatment | Baptist Healthhttps://www.baptisthealth.com/care-services/conditions-treatments/dumping-syndrome
Dumping syndrome is generally the unwanted result of bariatric or weight-reduction surgery. […] Dumping syndrome is one of the most common complications of bariatric surgery. Up to 50% of those who have had a gastrectomy may experience it. It also occurs in around 10% of those who have had any type of gastric surgery. […] You may be at risk for dumping syndrome if you undergo bariatric or esophageal surgery. Dumping syndrome is otherwise uncommon. […] Diagnosis of dumping syndrome is complicated by the fact that symptoms overlap with those of other medical conditions. The symptoms of early dumping syndrome are often similar to those of ulcers, internal hernias, and cases of fistula, ischemia, and stenosis. Late dumping syndrome shares symptoms with hypoglycemia and related medical concerns. Medical researchers have developed a variety of diagnostic tools for correctly differentiating dumping syndrome from these other conditions.
- #49 Dumping Syndrome: Symptoms, Causes, and Treatmenthttps://www.verywellhealth.com/what-to-do-for-dumping-syndrome-1945209
Dumping syndrome is most often seen in people who have had bariatric (weight loss), esophageal, or gastric surgery. […] Estimates of the number of people who experience dumping syndrome following gastric surgery range from 20% to 50%. […] The type of surgery you have also influences your risk of developing dumping syndrome. […] Most people with dumping syndrome experience the early form, while only about a quarter experiences the late-type. […] Late dumping syndrome results more exclusively from changes in blood glucose and insulin levels. […] In late dumping syndrome, symptoms are triggered because too much sugar is released into the small intestine too quickly. […] Dumping syndrome is diagnosed based on your medical history and symptoms. […] Your practitioner will evaluate you and advise you as to the best course of action.
- #50 Pathophysiology, diagnosis and management of postoperative dumping syndrome | Nature Reviews Gastroenterology & Hepatologyhttps://www.nature.com/articles/nrgastro.2009.148
Dumping syndrome is a frequent complication of esophageal, gastric or bariatric surgery. […] Diagnosis is based on a suggestive symptom pattern in patients with the appropriate surgical history; a modified oral glucose tolerance test might help to establish the diagnosis. […] In patients with treatment-refractory dumping syndrome, surgical reinterventions or continuous enteral feeding can be considered, but the outcomes of such approaches are variable.
- #51 International consensus on the diagnosis and management of dumping syndrome | Nature Reviews Endocrinologyhttps://www.nature.com/articles/s41574-020-0357-5
In spite of its effects, guidance is lacking on how to diagnose this condition, which is probably under-recognized. […] The literature has referred to late dumping syndrome as reactive hypoglycaemia or, after bariatric surgery, as postbariatric hypoglycaemia. […] The rapid expansion in the use of bariatric interventions has therefore led to an increasing number of patients with dumping syndrome. […] The panel agreed on the pathophysiological relevance of rapid passage of nutrients to the small bowel, on the role of decreased gastric volume capacity and release of glucagon-like peptide 1. […] An increase in haematocrit 3% or in pulse rate 10bpm 30min after the start of the glucose intake are diagnostic of early dumping syndrome, and a nadir hypoglycaemia level 50mg/dl is diagnostic of late dumping syndrome. […] The modified oral glucose tolerance test, but not gastric emptying testing, is useful for diagnosis.
- #52 Pathophysiology, diagnosis and management of postoperative dumping syndrome | Nature Reviews Gastroenterology & Hepatologyhttps://www.nature.com/articles/nrgastro.2009.148
Dumping syndrome is a frequent complication of esophageal, gastric or bariatric surgery. […] Diagnosis is based on a suggestive symptom pattern in patients with the appropriate surgical history; a modified oral glucose tolerance test might help to establish the diagnosis. […] In patients with treatment-refractory dumping syndrome, surgical reinterventions or continuous enteral feeding can be considered, but the outcomes of such approaches are variable.
- #53 Prevalence of Dumping Syndrome and Its – ProQuesthttps://www.proquest.com/scholarly-journals/prevalence-dumping-syndrome-determinants-among/docview/2771235288/se-2
Obesity has been recognized by the World Health Organization (WHO) as one of the most significant health problems worldwide; its prevalence has been increasing over the past decades despite extensive preventative efforts. […] Dumping syndrome (DS) has been reported as a common consequence of bariatric surgery; a reviewed study pointed to prevalence rates ranging from 19% to 32% due to variations in the type of surgery, definition, and diagnostic test used. […] Based on the modified Sigstad diagnostic scoring system for DS, 75 participants (31.4%) met the criteria (threshold value of 3.26) to be categorized as DS patients. […] The current study aimed at exploring the prevalence of DS and associated factors in patients who have undergone bariatric surgery in one of the main general hospitals in Jeddah, Saudi Arabia. […] The predictors include eating more than one large meal per day and drinking liquids with meals.
- #54 Azthena logo with the word Azthenahttps://www.news-medical.net/health/Dumping-Syndrome-Diagnosis.aspx
Dumping syndrome (DS) can be classified as early dumping syndrome (EDS) or late dumping syndrome (LDS) based on the timing of the symptoms after eating. It is a condition that is seen in up to 20% of individuals who undergo gastric, bariatric or esophageal surgeries. […] If the diagnosis of DS is dubious then oral glucose and hydrogen breath tests come in very handy as they have 100% sensitivity and 92% specificity. […] The evaluation of the upper GI tract is imperative to confirm LDS because there are other conditions that may produce similar symptoms.
- #55 Complications of Bariatric Surgery: Dumping Syndrome and Drug Dispositionhttps://www.pharmacytimes.com/view/complications-of-bariatric-surgery-dumping-syndrome-and-drug-disposition
Dumping syndrome is a side effect of malabsorptive bariatric procedures such as RYGB and biliopancreatic diversion. Approximately 40% of people who undergo bariatric surgery develop dumping syndrome, and most studies report that it does not increase or decrease weight loss. […] Dumping syndrome can also occur in patients who have not had bariatric surgery. People with diabetes, vagotomy, pancreatic exocrine insufficiency, duodenal ulcer, Zollinger-Ellison syndrome or extensive upper gastrointestinal repair sometimes develop dumping syndrome. […] Bariatric surgeons diagnose dumping syndrome based on the patientâs report of symptoms and observation of the patient after a carbohydrate-rich meal. Additionally, surgeons record postprandial serial pulse rate and hematocrit to screen for cardiovascular effects, and perform prolonged postprandial glucose testing to confirm reactive hypoglycemia. Scintigraphic (radioactive tracing) gastric emptying tests are also helpful, especially if the condition is related to a nonsurgical problem (eg, diabetes mellitus).
- #56 Dumping Syndrome: Updated Perspectives on Etiologies and Diagnosis – Practical Gastrohttps://practicalgastro.com/2014/10/18/dumping-syndrome-updated-perspectives-on-etiologies-and-diagnosis/
Among etiologic factors of DS in our patient group, DM was the most common. […] These findings emphasize a crucial role for scintigraphic GET in patients who have the symptoms of DS, even in the absence of a recent gastric surgery. This is essential to make the diagnosis of DS and effectively treat patients with this condition.
- #57 Azthena logo with the word Azthenahttps://www.news-medical.net/health/Dumping-Syndrome-Diagnosis.aspx
Dumping syndrome (DS) can be classified as early dumping syndrome (EDS) or late dumping syndrome (LDS) based on the timing of the symptoms after eating. It is a condition that is seen in up to 20% of individuals who undergo gastric, bariatric or esophageal surgeries. […] If the diagnosis of DS is dubious then oral glucose and hydrogen breath tests come in very handy as they have 100% sensitivity and 92% specificity. […] The evaluation of the upper GI tract is imperative to confirm LDS because there are other conditions that may produce similar symptoms.
- #58 Top Published Expert Doctors for Dumping Syndromehttps://findexpertmd.com/d/Dumping_Syndrome
216 top medical experts on Dumping Syndrome across 24 countries and 18 U.S. states, including 52 MDs (Physicians). This is based on an objective analysis of their Scientific Publications, Clinical Trials, Medicare, and NIH Grants. […] Clinical Trials ClinicalTrials.gov: at least 15 including 2 Active, 8 Completed, 1 Recruiting.
- #59 Dumping Syndrome Gastric Sleeve: How to Prevent & Managehttps://www.nycbariatrics.com/blog/how-to-prevent-and-manage-dumping-syndrome-gastric-sleeve/
These lifestyle modifications are particularly beneficial for individuals who have undergone weight loss surgery to manage symptoms of dumping syndrome. […] Preventive measures are crucial for individuals who have undergone weight loss surgery to avoid the onset of dumping syndrome. […] Effective management of dumping syndrome necessitates regular monitoring and follow-up. […] By staying vigilant and proactive, individuals can significantly reduce the risk of complications and improve their overall health and well-being.
- #60https://link.springer.com/article/10.1245/s10434-024-15881-x
Dumping syndrome occurs frequently after esophageal cancer surgery, but the reported prevalence varied across previous studies. […] The prevalence of dumping syndrome ranged 0-74% in these studies, showing high heterogeneity (I2 = 99%, P 0.01), with the pooled prevalence of 27% (95% confidence interval [CI] 14-39%). […] Our findings revealed that dumping syndrome is common after esophageal cancer surgery. […] Previous studies have reported varying prevalence of dumping syndrome after esophageal cancer surgery. […] The pooled prevalence was higher in studies using specialized questionnaires for measuring dumping syndrome with reduced heterogeneity across studies. […] The prevalence of dumping syndrome also was higher in studies published in 2000 or later than in earlier studies, was higher in Western populations than in Eastern Asian populations, and varied by length and completeness of follow-up.
- #61https://link.springer.com/article/10.1245/s10434-024-15881-x
Dumping syndrome occurs frequently after esophageal cancer surgery, but the reported prevalence varied across previous studies. […] The prevalence of dumping syndrome ranged 0-74% in these studies, showing high heterogeneity (I2 = 99%, P 0.01), with the pooled prevalence of 27% (95% confidence interval [CI] 14-39%). […] Our findings revealed that dumping syndrome is common after esophageal cancer surgery. […] Previous studies have reported varying prevalence of dumping syndrome after esophageal cancer surgery. […] The pooled prevalence was higher in studies using specialized questionnaires for measuring dumping syndrome with reduced heterogeneity across studies. […] The prevalence of dumping syndrome also was higher in studies published in 2000 or later than in earlier studies, was higher in Western populations than in Eastern Asian populations, and varied by length and completeness of follow-up.
- #62https://link.springer.com/article/10.1245/s10434-024-15881-x
The considerably high prevalence of dumping syndrome after esophageal cancer surgery, particularly as reported in studies using specific symptom-based questionnaires, should draw attention from medical personnel and caregivers. […] Therefore, more well-designed studies are needed to identify the risk factors for dumping syndrome after esophageal cancer surgery, explore the physical and functional reasons behind dumping syndrome, and assess strategies preventing its occurrence and improving management of dumping syndrome. […] This systematic review and meta-analysis comprehensively synthesizing the existing evidence suggests considerably high prevalence of postoperative dumping syndrome in esophageal cancer patients.
- #63 International consensus on the diagnosis and management of dumping syndrome | Nature Reviews Endocrinologyhttps://www.nature.com/articles/s41574-020-0357-5
Dumping syndrome is a common but underdiagnosed complication of gastric and oesophageal surgery. […] The prevalence of dumping syndrome depends on the type and extent of surgery, and on the criteria used to diagnose dumping syndrome. Dumping syndrome occurs in approximately 20% of patients undergoing vagotomy with pyloroplasty, in up to 40% of patients after Roux-en-Y gastric bypass (RYGB) or sleeve gastrectomy and in up to 50% of patients undergoing oesophagectomy. […] According to reports published in the past 15 years, bariatric surgery has become the main cause of postoperative dumping syndrome. […] Symptoms of dumping syndrome are often debilitating and emotionally distressing, they are associated with a substantial reduction in quality of life and might lead to considerable weight loss as a result of the patient avoiding food intake.
- #64 What is dumping, and why am I experiencing it? – Obesity Action Coalitionhttps://www.obesityaction.org/resources/what-is-dumping-and-why-am-i-experiencing-it/
Dumping syndrome is a common post-surgical complication after gastric surgery. […] The symptoms of dumping may cause considerable morbidity. […] If medical management fails to provide adequate symptom relief, remedial surgery should be offered with the understanding that even surgical intervention may not be successful. […] Normally most patients have a spontaneous recovery as the digestive system adapts after surgery. […] Early dumping syndrome usually occurs for three to four months after surgery. […] Late dumping syndrome can occur for an entire year, but may persist for many years.
- #65 SciELO Brazil – PATHOPHYSIOLOGY, DIAGNOSIS AND TREATMENTOF DUMPING SYNDROME AND ITS RELATION TO BARIATRIC SURGERY PATHOPHYSIOLOGY, DIAGNOSIS AND TREATMENTOF DUMPING SYNDROME AND ITS RELATION TO BARIATRIC SURGERYhttps://www.scielo.br/j/abcd/a/c85MgtFzcsLqhYTrrWNpHvM/
The dumping syndrome is frequent in bariatric surgery. It is probably the most common syndrome following partial or complete gastrectomy. Its prevalence in partial gastrectomy can reach up to 50%, thus it can be a significant complication arising from some types of bariatric surgeries. […] The dumping syndrome may be present on bariatric surgical procedures; its prevalence may reach up to 50% in partial gastrectomy. It is probably the most common syndrome that follow gastrectomy. […] It occurs after complete or partial gastrectomy, thereby becoming a significant complication arising from certain types of bariatric procedures involving gastrectomy; it also can happens as a consequence of damage to the vagus nerve. […] The increasing number of patients undergoing bariatric surgery will result in increasing numbers of patients with gastrointestinal complications.
- #66 SciELO Brazil – PATHOPHYSIOLOGY, DIAGNOSIS AND TREATMENTOF DUMPING SYNDROME AND ITS RELATION TO BARIATRIC SURGERY PATHOPHYSIOLOGY, DIAGNOSIS AND TREATMENTOF DUMPING SYNDROME AND ITS RELATION TO BARIATRIC SURGERYhttps://www.scielo.br/j/abcd/a/c85MgtFzcsLqhYTrrWNpHvM/
The Brazilian Society of Bariatric and Metabolic Surgery claims that the demand for surgical procedures to combat obesity is growing about 20% per year in Brazil; so, it is important to direct actions aiming to aware the population about the hardships to which they are exposed, where dumping syndrome is included.
- #67 Content – Health Encyclopedia – University of Rochester Medical Centerhttps://www.urmc.rochester.edu/encyclopedia/content.aspx?ContentTypeID=134&ContentID=107
Dumping syndrome occurs in approximately 20% to 50% of those who have had gastric surgery. […] The main treatment for dumping syndrome is changes in your diet. […] Talk with your healthcare provider if you have symptoms of dumping syndrome. […] If the dietary changes don’t help, you may need to take slow-release prescription medicine.
- #68 Dumping Syndrome: Diagnosis, Treatment, Symptoms & Causeshttps://my.clevelandclinic.org/health/diseases/17835-dumping-syndrome
Dumping syndrome most commonly happens as a complication of surgery on your stomach, or on your esophagus where it connects to your stomach. An estimated 20% to 50% of people who have had stomach surgery develop some symptoms of dumping syndrome. It’s most common in people who have had surgeries that remove or bypass large portions of the stomach, such as gastrectomy or gastric bypass surgery. […] Dumping syndrome is one of the most common post-gastrectomy syndromes that affect people recovering from surgery. There’s a good chance you may experience some symptoms immediately following your procedure. Fortunately, most cases are mild and go away on their own in a few weeks to months.
- #69 Gastric dumping syndrome epidemiology and demographics – wikidochttps://www.wikidoc.org/index.php/Gastric_dumping_syndrome_epidemiology_and_demographics
Incidence and prevalence varies depending on the procedure or disease leading to dumping syndrome. […] The incidence of patients who have undergone gastric surgery ranges from approximately 20,000 to 50,000 per 100,000. […] After truncal vagotomy with drainage the incidence of dumping syndrome has been reported to be 6,000 to 14,000 per 100,000. […] After proximal vagotomy without drainage the incidence of dumping syndrome has been reported to be is less than 2,000 per 100,000. […] After partial gastrectomy the incidence of dumping syndrome has been reported to be 14,000 to 20,000 per 100,000. […] Since the advent of proton pump inhibitors, the need for surgery has decreased and so has the incidence of dumping syndrome. […] In gastric surgery 1 out of 10 people develop dumping symptoms.
- #70 Gastroparesis and Dumping Syndrome: Current Concepts and Managementhttps://www.mdpi.com/2077-0383/8/8/1127
Gastroparesis and dumping syndrome are frequent, but their prevalence and incidence vary depending on definitions and studied populations. Therefore, heterogenous results have been reported in the literature. […] The prevalence of gastroparesis in the general population is uncertain. A wide range in different at-risk populations has been reported. In addition, gastroparesis is likely significantly under diagnosed. […] Reliable population-based prevalence data for dumping syndrome are still lacking. As of yet, the frequency of postsurgical dumping syndrome is estimated at 25%â50% with 5 to 10% of patients experiencing a severe disabling form. […] The incidence and prevalence of dumping syndrome has been increasing due to the current obesity epidemics and the consecutive climb in gastric bypass surgeries.
- #71 International consensus on the diagnosis and management of dumping syndrome | Nature Reviews Endocrinologyhttps://www.nature.com/articles/s41574-020-0357-5
Dumping syndrome is a common but underdiagnosed complication of gastric and oesophageal surgery. […] The prevalence of dumping syndrome depends on the type and extent of surgery, and on the criteria used to diagnose dumping syndrome. Dumping syndrome occurs in approximately 20% of patients undergoing vagotomy with pyloroplasty, in up to 40% of patients after Roux-en-Y gastric bypass (RYGB) or sleeve gastrectomy and in up to 50% of patients undergoing oesophagectomy. […] According to reports published in the past 15 years, bariatric surgery has become the main cause of postoperative dumping syndrome. […] Symptoms of dumping syndrome are often debilitating and emotionally distressing, they are associated with a substantial reduction in quality of life and might lead to considerable weight loss as a result of the patient avoiding food intake.
- #72 Dumping Syndrome: Background, Pathophysiology, Etiologyhttps://emedicine.medscape.com/article/173594-overview
Reductions in the need for elective gastric surgery have led to a decline in the frequency of postgastrectomy syndromes. […] A 10-fold reduction has occurred in elective operations for peptic ulcer disease in the last 20-30 years. […] Although this trend preceded the advent of histamine-2 receptor antagonists, these drugs and proton pump inhibitors have accelerated the decline. […] Helicobacter pylori treatment and eradication in patients with peptic ulcer disease have further decreased the need for surgery. […] Although the need for elective surgery for peptic ulcer disease has declined, the need for emergency surgery has remained the same over the last 20 years. […] Emergency surgery tends to be more mutilating to the stomach. […] This increases the incidence of more severe symptoms.
- #73 International consensus on the diagnosis and management of dumping syndrome | Nature Reviews Endocrinologyhttps://www.nature.com/articles/s41574-020-0357-5
In spite of its effects, guidance is lacking on how to diagnose this condition, which is probably under-recognized. […] The literature has referred to late dumping syndrome as reactive hypoglycaemia or, after bariatric surgery, as postbariatric hypoglycaemia. […] The rapid expansion in the use of bariatric interventions has therefore led to an increasing number of patients with dumping syndrome. […] The panel agreed on the pathophysiological relevance of rapid passage of nutrients to the small bowel, on the role of decreased gastric volume capacity and release of glucagon-like peptide 1. […] An increase in haematocrit 3% or in pulse rate 10bpm 30min after the start of the glucose intake are diagnostic of early dumping syndrome, and a nadir hypoglycaemia level 50mg/dl is diagnostic of late dumping syndrome. […] The modified oral glucose tolerance test, but not gastric emptying testing, is useful for diagnosis.
- #74 Complications of Bariatric Surgery: Dumping Syndrome and Drug Dispositionhttps://www.pharmacytimes.com/view/complications-of-bariatric-surgery-dumping-syndrome-and-drug-disposition
Dumping syndrome is a side effect of malabsorptive bariatric procedures such as RYGB and biliopancreatic diversion. Approximately 40% of people who undergo bariatric surgery develop dumping syndrome, and most studies report that it does not increase or decrease weight loss. […] Dumping syndrome can also occur in patients who have not had bariatric surgery. People with diabetes, vagotomy, pancreatic exocrine insufficiency, duodenal ulcer, Zollinger-Ellison syndrome or extensive upper gastrointestinal repair sometimes develop dumping syndrome. […] Bariatric surgeons diagnose dumping syndrome based on the patientâs report of symptoms and observation of the patient after a carbohydrate-rich meal. Additionally, surgeons record postprandial serial pulse rate and hematocrit to screen for cardiovascular effects, and perform prolonged postprandial glucose testing to confirm reactive hypoglycemia. Scintigraphic (radioactive tracing) gastric emptying tests are also helpful, especially if the condition is related to a nonsurgical problem (eg, diabetes mellitus).
- #75 Dumping Syndrome Gastric Sleeve: How to Prevent & Managehttps://www.nycbariatrics.com/blog/how-to-prevent-and-manage-dumping-syndrome-gastric-sleeve/
These lifestyle modifications are particularly beneficial for individuals who have undergone weight loss surgery to manage symptoms of dumping syndrome. […] Preventive measures are crucial for individuals who have undergone weight loss surgery to avoid the onset of dumping syndrome. […] Effective management of dumping syndrome necessitates regular monitoring and follow-up. […] By staying vigilant and proactive, individuals can significantly reduce the risk of complications and improve their overall health and well-being.
- #76 Dumping syndrome: Causes, management, and patient educationhttps://www.myamericannurse.com/dumping-syndrome/
Dumping syndrome (DS), a well-established yet under-recognized side effect of upper GI surgery, occurs when the body reacts to food moving too rapidly from the stomach into the intestine, resulting in unpleasant symptoms such as a pounding pulse, sweating, dizziness, and nausea. […] DS occurs after 20% to 75% of all esophageal and gastric surgeries. Its incidence decreased during the 20th century when the discovery of Helicobacter pylori made most gastric surgical interventions to treat chronic gastritis and peptic ulcer disease unnecessary and treatment shifted to medication. But the recent increase in bariatric surgery and gastric or esophageal surgery to treat cancer has led to an increase in the incidence of DS. […] Many people who have undergone upper GI surgery aren’t aware of DS and haven’t been adequately educated about it. In addition, DS symptoms frequently are misdiagnosed. Nurses and other healthcare providers should understand the etiology, symptoms, and management of DS to educate patients and to improve their health outcomes and quality of life.