Materiały źródłowe

• #1 Gilbert syndrome – Diagnosis & treatment – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/gilberts-syndrome/diagnosis-treatment/drc-20372816

  Gilbert syndrome doesn’t require treatment. The bilirubin levels in your blood may fluctuate over time. You may occasionally have jaundice, which usually resolves on its on with no ill effects. […] Taking steps to manage those situations can help keep bilirubin levels under control. […] Make sure your health care providers know you have Gilbert syndrome. Because Gilbert syndrome affects the way your body processes certain medications, every provider you visit needs to know that you have the condition. […] Is there anything I can do to maintain a low bilirubin level?

• #2 Gilbert’s Syndrome: Symptoms, Causes, Tests & Treatment

  https://my.clevelandclinic.org/health/diseases/17661-gilberts-syndrome

  Because this liver disease doesnt cause serious problems, treatment isnt necessary. […] Jaundice can cause a yellowish appearance that may be unsettling. However, jaundice and Gilbert’s syndrome dont require treatment. […] Gilbert’s syndrome is a mild disorder that doesnt require treatment. While occasional yellowish eyes and skin may be unsettling, jaundice doesnt pose any health risks. This skin and eye coloration will go away on its own. Your healthcare provider can suggest ways to reduce episodes of jaundice associated with Gilbert’s syndrome.

• #3 Patient education: Gilbert syndrome (Beyond the Basics) – UpToDate

  https://www.uptodate.com/contents/gilbert-syndrome-beyond-the-basics/print

  Gilbert syndrome is not dangerous and does not cause long-term problems, so it is not necessary to treat Gilbert syndrome. […] No specific treatment is required for people with Gilbert syndrome. However, there is an increased risk of side effects from certain drugs that are broken down by the liver (such as acetaminophen and the chemotherapy drug, irinotecan). Check with a health care provider before taking any new medications. Do not take more than the recommended amount of acetaminophen (Tylenol).

• #4 Gilbert Syndrome – StatPearls – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK470200/

  Patients with Gilbert syndrome do not require treatment. […] Therefore, management primarily consists of reassuring patients and their families that this is a benign condition that does not require further testing. […] However, patients, family members, and clinicians should be counseled that individuals with Gilbert syndrome may be at an increased risk of drug toxicity when exposed to medications that suppress or affect UGT1A1 activity. […] The prognosis of patients with Gilbert syndrome is excellent. […] Patients with Gilbert syndrome have an excellent prognosis. […] Outcomes of patients with Gilbert syndrome are similar to that of the general population. […] Patients and their families should be informed of the disease’s inherited and benign nature, and unnecessary testing should be avoided.

• #5 Gilbert syndrome: Symptoms, diet, and treatment

  https://www.medicalnewstoday.com/articles/166971

  Gilbert syndrome is considered harmless, because it does not usually cause any health problems. As a result, no treatment is required. […] Gilbert syndrome does not need treatment, but, again, it is important to make sure that the person does not have another, more serious, condition.

• #6 Gilbert’s syndrome

  https://www.rch.org.au/kidsinfo/fact_sheets/gilberts_syndrome/

  Gilbert’s syndrome does not require treatment, and it will not interfere with a normal lifestyle. […] Gilbert’s syndrome does not require treatment and will not interfere with a normal lifestyle.

• #7 Unconjugated Hyperbilirubinemia Treatment & Management: Approach Considerations, Nonsurgical Correction of Bilirubin Levels, Liver and Hepatocyte Transplantation

  https://emedicine.medscape.com/article/178841-treatment

  Once the diagnosis of Gilbert syndrome is established, the most important aspect of treatment is reassurance. The clinician must make it perfectly clear to the patient that the syndrome is essentially benign, is not associated with increased morbidity (except for an increased incidence of side effects from certain drugs, such as the antitumor agent irinotecan), has an excellent prognosis, and is associated with normal life expectancy. In light of the benign and inconsequential nature of Gilbert syndrome, the use of medications to treat patients with this condition is unjustified in clinical practice. […] No therapy is necessary for patients with Gilbert syndrome. However, many therapeutic approaches have been used. As with Crigler-Najjar type II syndrome, phenobarbital has been shown to decrease bilirubin production. The most important aspect in the care of patients with Gilbert syndrome, however, is recognition of the disorder and its inconsequential nature.

• #8 Patient education: Gilbert syndrome (Beyond the Basics) – UpToDate

  https://www.uptodate.com/contents/gilbert-syndrome-beyond-the-basics

  No specific treatment is required for people with Gilbert syndrome. […] However, there is an increased risk of side effects from certain drugs that are broken down by the liver (such as acetaminophen and the chemotherapy drug, irinotecan). Check with a health care provider before taking any new medications. Do not take more than the recommended amount of acetaminophen (Tylenol).

• #9 Gilbert’s syndrome | Better Health Channel

  https://www.betterhealth.vic.gov.au/health/conditionsandtreatments/gilberts-syndrome

  Gilberts syndrome is considered harmless and typically doesn’t need medical treatment. […] Gilberts syndrome is a mild disorder that typically doesn’t need medical treatment. People with the disorder lead normal, healthy lives. There is no evidence to suggest that the condition is harmful or leads to more serious diseases. […] Occasionally, the presence of Gilberts syndrome may increase the toxicity of certain drugs used for therapy of severe disorders. These drugs include irinotecan (used in the treatment of cancer) and indinavir (used in the treatment of HIV/AIDS). There is no evidence that Gilberts syndrome has any effect on most commonly used medicines. […] However, a patient with Gilberts syndrome would be wise to seek further advice from their medical practitioner before starting a new medication.

• #10 Gilbert’s syndrome

  https://www.eviq.org.au/clinical-resources/side-effect-and-toxicity-management/prophylaxis-and-treatment/1736-gilbert-s-syndrome

  Patients with Gilbert’s syndrome should have their dose of irinotecan reduced. There is no clear dosing strategy; however, based on the area under the concentration-time curve of SN-38, Innocenti et al (2006) recommend a 20% dose reduction of irinotecan. […] Consider starting sacituzumab govitecan at a lower dose in patients with Gilberts syndrome, and dose escalation depending on toxicity with cycle 1. […] Patients should be advised that the precise dose reduction is not known, and subsequent dose modifications may be required on the basis of individual tolerance to treatment.

• #11 Gilbert’s Syndrome | Doctor

  https://patient.info/doctor/gilberts-syndrome-pro

  Gilbert’s syndrome is characterised by a mild and intermittent unconjugated hyperbilirubinaemia, with no evidence of haemolysis or liver disease, and with normal liver function tests. […] As it is a benign condition and is not associated with liver disease or reduced life expectancy, genetic counselling is not necessary. […] This is excellent. No treatment is required, it cannot progress to chronic liver disease, and life expectancy is normal. […] The following drugs should be avoided or used with caution in people who have Gilbert’s syndrome; testing for UGT1A1 gene variants may be indicated: Atazanavir and indinavir (used for the treatment of HIV infection). […] Bilirubin may have protective effects. It is an endogenous antioxidant. […] Having Gilbert’s syndrome appears to reduce the risk of various age-related diseases, particularly cancer.

• #12 Gilbert’s Syndrome – Reduce Symptoms & Support Liver Health

  https://advancedfunctionalmedicine.com.au/gilbert-syndrome/

  Its important to note that Gilbert syndrome can interact with some medications, including cancer therapy drugs. […] If you know that you have Gilberts syndrome, you may find that you are sensitive to alcohol and its best to avoid consuming it. In Functional Medicine, however, we can treat symptoms with lifestyle and diet changes and supplements to reduce symptoms of jaundice and associated symptoms, as well as boost the function of the liver. […] Generally, our advice is to stay healthy eat well, sleep well, avoid restrictive diets, avoid alcohol, exercise regularly and stay hydrated. […] You may also like to try some supplements and teas to detoxify and keep your liver healthy. […] It is also important to try to avoid drugs that require detoxification by the liver, including acetaminophen which is an active ingredient in Panadol.

• #13 Common genetic disorder linked to increased death rate from cancer drug | Fred Hutchinson Cancer Center

  https://www.fredhutch.org/en/news/center-news/2016/10/gilbert-syndrome-chemotherapy-risk.html

  Researchers recommend caution when using the chemotherapy busulfan in patients with Gilberts syndrome. […] Until the finding is replicated by other bone marrow transplantation groups around the world, the research team recommends that transplant physicians carefully consider the use of busulfan in patients with Gilberts syndrome. […] If I have a patient with Gilberts and I have a choice of similarly effective drugs, with [a recommendation for] caution, I might use the other regimen, McDonald said. […] Patients being treated with busulfan through the Fred Hutch/UW Cancer Consortium already have a system in place to lower the risk of getting dangerously overdosed or underdosed with this drug a clinical lab established by Fred Hutch researchers years ago that tests patient blood samples early in treatment to learn how the medication is being metabolized, allowing the physician to lower or raise subsequent doses.

• #14 Gilbert’s Syndrome: Symptoms, Causes, Diagnosis, and Treatment

  https://www.healthline.com/health/gilberts-syndrome

  Most cases of Gilberts syndrome dont require treatment. However, if you start to have significant symptoms, including fatigue or nausea, your doctor might prescribe daily phenobarbital (Luminal) to help reduce the total amount of bilirubin in your body. […] There are also several lifestyle changes you can make to help prevent symptoms, including: […] Get plenty of sleep. Try to sleep seven to eight hours a night. Follow a consistent routine as closely as you can. […] Avoid long periods of intense exercise. Keep strenuous workouts short (under 10 minutes). Try to get at least 30 minutes of light to moderate exercise each day. […] Stay well hydrated. This is especially important during exercise, hot weather, and illness. […] Try relaxation techniques to cope with stress. Listen to music, meditate, do yoga, or try other activities that help you relax.

• #14 Gilbert’s Syndrome: Symptoms, Causes, Diagnosis, and Treatment

  https://www.healthline.com/health/gilberts-syndrome

  Eat a balanced diet. Eat regularly, dont skip any meals, and dont follow any diet plans that recommend fasting or eating only small amounts of calories. […] Limit alcohol intake. If you have any liver condition, its best to avoid alcohol. However, if you do drink, consider limiting yourself to only a few drinks per month. […] Learn how your medications interact with Gilberts syndrome. Some medications, including some used to treat cancer, may work differently if you have Gilberts syndrome.

• #15 Gilbert’s Syndrome – Reduce Symptoms & Support Liver Health

  https://advancedfunctionalmedicine.com.au/gilbert-syndrome/

  Gilbert syndrome, pronounced jeel-bears, is a common, harmless liver condition in which the liver doesn’t properly process bilirubin. […] Although Gilberts syndrome does not usually cause serious problems and does not need treatment, you can avoid triggers that raise your bilirubin levels to keep jaundice, (the yellowing of the skin and whites of the eyes), at bay. […] Generally, eating a healthy diet, staying hydrated, avoiding alcohol, avoiding dieting, fasting and skipping meals, and managing your stress levels will keep your symptoms under control. […] As Gilbert syndrome is generally harmless, conventional medicine does not usually treat the condition. It will not damage the liver and apart from jaundice, there are no known complications. […] It can, however, complicate other conditions. Specifically, people with the syndrome who also have another condition that increases bilirubin levels, such as sickle cell anaemia, run a higher risk of getting gallstones.

• #15 Gilbert’s Syndrome – Reduce Symptoms & Support Liver Health

  https://advancedfunctionalmedicine.com.au/gilbert-syndrome/

  Going too long without eating can bring on the symptoms of Gilberts syndrome, as can extremely low-calorie diets. […] Stick to a routine eating schedule and avoid fasting or skipping meals. […] Exercise reduces inflammation in the liver and many studies have shown a correlation between increased exercising and improvement in liver function. […] Stress can cause an inflammatory response in the liver so if you have Gilbert syndrome, it can exacerbate symptoms. […] The liver is responsible for processing and removing toxins from the body, so its important to reduce its workload if you have been diagnosed with Gilbert syndrome. […] At Advanced Functional Medicine, our team of experts can assist you in restoring your liver to its optimal health. If you have had a diagnosis of Gilberts syndrome, we will take a holistic view of your overall health to reduce any symptoms you may be experiencing and ensure you are as well as you can be.

• #16 All about Gilbert Syndrome – Mun Kombucha

  https://munkombucha.com/en/blogs/all/all-about-gilbert-syndrome?srsltid=AfmBOoqNfF85ic5oZ7bFI3b0FNC-0vaBFJoaRqDernboiyLu5MeuC6QS

  Quercetin (a flavonoid supplement) and curcumin (from turmeric) increase the activity of the UGT enzyme, according to an animal study. […] Star foods for the liver include: broccoli, garlic, turmeric, avocado, beets, apples, lemons and walnuts. […] In general there is no food to avoid. On the other hand, it is advisable to eat healthy and consume enough vegetables and fruits. It is also important not to skip any meals, that is, to find a routine, controlling that you eat enough calories each day and not fasting. […] It is important to include foods rich in fiber to keep the liver healthy. Include fruits, vegetables, whole grains and legumes in your daily life. […] The only food to reduce or eliminate would be alcohol. […] If you suffer from Gilbert’s Syndrome, it may be a good idea to start drinking kombucha on a recurring basis. Keep in mind that kombucha may contain small amounts of alcohol. Some Gilberts cannot even tolerate these low amounts of alcohol. Start with small amounts of kombucha and see how your body reacts. If you see that it has no negative effects on your body, progressively increase the amount of kombucha you drink daily, and look for a balance point.

• #16 All about Gilbert Syndrome – Mun Kombucha

  https://munkombucha.com/en/blogs/all/all-about-gilbert-syndrome?srsltid=AfmBOoqNfF85ic5oZ7bFI3b0FNC-0vaBFJoaRqDernboiyLu5MeuC6QS

  In general, Gilbert’s Syndrome does not require treatment, but if the symptoms cause discomfort, ways can be sought to alleviate them or keep them under control. You have to act on 4 pillars: […] Treatment for Gilbert’s Syndrome should be focused on reducing the toxins to be eliminated through glucuronidation or improving the performance of glucuronidation and UGT enzymes. […] Reduce carbohydrate intake, especially those that come from refined foods, such as flour or sugars. Increase protein and fat consumption. Not enough studies have been done yet, but a paleo or keto diet could improve bilirubin levels. […] Cruciferous vegetables cause the body to increase the production of UGT1A1. Cruciferous vegetables include broccoli, kale, Brussels sprouts, cauliflower, and cabbage. […] If you don’t eat enough cruciferous vegetables, I3C and DIM (diindolylmethane) supplements are available. These are produced from the part of cruciferous vegetables that induce UGT1A1.

• #17 Gilbert syndrome | Altru Health System

  https://www.altru.org/health-library/conditions/gilbert-syndrome

  Gilbert syndrome requires no treatment. […] Gilbert syndrome doesn’t require treatment. The bilirubin levels in your blood may fluctuate over time. You may occasionally have jaundice, which usually resolves on its on with no ill effects. […] Make sure your health care providers know you have Gilbert syndrome. Because Gilbert syndrome affects the way your body processes certain medications, every provider you visit needs to know that you have the condition. […] Eat a healthy diet. Avoid extremely low-calorie diets. Stick to a routine eating schedule, and avoid fasting or skipping meals. […] Manage stress. Find ways to deal with the stresses in your life. Exercise, meditation and listening to music may be helpful.

• #18 Gilbert’s syndrome | The London Clinic

  https://www.thelondonclinic.co.uk/services/conditions/gilberts-syndrome

  At The London Clinic we offer advanced genetic testing and diagnosis for Gilberts syndrome. […] There is no cure for Gilberts syndrome as it is caused by a specific gene in DNA, and this makes it a lifelong condition. […] Its not a threat to your health and wont increase your risk of liver disease, however there are ways to improve and manage your symptoms. […] For example, you need to avoid medication or drugs that inhibit the UGT enzyme or impair the breakdown of red blood cells, such as: […] Speak to your specialist about any medications youre taking to ensure they dont require the UGT enzyme to help clear them from your body, and that they dont impair the breakdown of red blood cells. […] Reducing how much alcohol you drink may be something you want to consider, as people who have Gilberts syndrome tend to experience hangovers that are more severe than people who dont. […] Jaundice and Gilberts syndrome do not damage the liver or cause complications so theres no specific treatment for it. […] Most people manage the condition by taking extra care of themselves when they are ill or under stress so their body can recover more quickly.

• #19 Got High Bilirubin? Get A Load Of Gilberts Syndrome – A Gut-Brain Phenomenon – Sydney Naturopath & Nutritionist

  https://stevenjudge.com.au/got-high-bilirubin-get-a-load-of-gilberts-syndrome-a-gut-brain-phenomenon/

  Supplements To Support Glucuronidation – Discuss With Your Practitioner: Calcium-D-Glucurate, Broccoli Sprout (Sulforaphane), Zinc, SAMe, Magnesium + B-Vitamins, Herbal medicines – bile-stimulating & bitter herbal medicines help increase bile flow, reduce gallbladder stagnation and increase overall bilirubin output. […] Fibre & Prebiotics – help to reduce bacterial species in the gut that produce beta-glucuronidase, speed up transit time and stimulate the growth of beneficial gut bacteria that reduce bilirubin. […] Intestinal Permeability support -Probiotics, Quercetin, Glutamine, Vitamin D, Anti-inflammatory herbal medicines, EPA/DHA (Omega-3), Zinc Carnosine can all be helpful here.

• #19 Got High Bilirubin? Get A Load Of Gilberts Syndrome – A Gut-Brain Phenomenon – Sydney Naturopath & Nutritionist

  https://stevenjudge.com.au/got-high-bilirubin-get-a-load-of-gilberts-syndrome-a-gut-brain-phenomenon/

  Gilbert’s Syndrome treatment should be multi-layered and focused around supporting the glucuronidation detoxification pathway, digestive function, gut microbiome, leaky gut and dietary & lifestyle strategies. Please consult with your doctor before ceasing any medications. […] The following compounds & dietary factors directly slow down UGT enzyme function & increase bilirubin levels: Alcohol, Oestrogen – Oral Contraceptive Pill (OCP), Hormone Replacement Therapy (HRT), Retinoids (Vitamin A) – Vitamin A supplements inhibit the UGT enzyme, so high-doses are not recommended. Interestingly, the medication acne Roaccutane reduces liver toxicity and normalises bilirubin levels in Gilbert’s Syndrome patients. […] Stress management, HPA Axis support & balancing out physical exercise with restorative practices (breathwork, yoga etc.) are all highly beneficial for Gilbert’s Syndrome.

• #20 Gilbert’s Syndrome + 10 Natural Ways to Boost Liver Health – Dr. Axe

  https://draxe.com/health/gilberts-syndrome/

  Combining Gilberts syndrome with alcohol consumption isnt recommended. […] If you drink, consider quitting. At the very least, with a liver condition, limit your alcohol to one drink a day for women and two drinks a day for men. […] Take 150 milligrams of milk thistle twice a day to help detox the liver and protect against chronic liver disease. […] Take 1,000 milligrams of a high-quality fish oil supplement daily to improve liver function. […] Eat probiotic-rich foods and take a high-quality probiotic supplement with at least 50 billion CFUs daily. […] Researchers urge further study to determine the ideal dosage for specific liver conditions.

• #21

  https://npistanbul.com/en/what-is-gilbert-syndrome

  While there is no specific treatment, patients should generally try to maintain a healthy lifestyle by avoiding certain triggers. […] Treatment for Gilbert syndrome is usually focused on managing symptoms and improving the patient’s quality of life. While there is no specific drug treatment, lifestyle changes are aimed at alleviating symptoms. […] When medication is required, drugs such as phenobarbital can be used in certain cases. However, it is important to discuss any treatment decisions with a health professional.

• #22

  https://journals.lww.com/hemasphere/abstract/2019/06001/pb2283_treatment_of_gilbert_syndrome_complicated.2147.aspx

  Gilbert syndrome is a mild, hereditary unconjugated hyperbilirubinemia without liver dysfunction or hemolytic anemia. […] Therefore, it is crucial to diagnose Gilbert syndrome and treat the high bilirubin levels, especially for patients who require chemotherapy or targeted drugs. […] Patients were then treated for their primary disease and given ursodeoxycholic acid (UDCA) either with or without phenobarbitone. […] After UDCA treatment was initiated, the total bilirubin and unconjugated bilirubin concentrations were approximately 43.8 mol/l and 37.6 mol/l, respectively. […] Imatinib was used to control his CML, and UDCA (250 mg p.o. qd or bid) was used to control his bilirubin levels. […] After 1 month of treatment, his total bilirubin level decreased to 71.6 mol/l. […] Furthermore, our results suggest that UDCA can reduce the bilirubin concentration in these patients with lower levels of bilirubin. But for patients with higher levels of bilirubin (higher than 100 mol/l), however, UDCA is not as effective, and phenobarbitone should be added to the treatment, especially in patients requiring urgent treatment.

• #23 Gilbert’s Syndrome | Symptoms, Diagnosis & Treatment

  https://www.cincinnatichildrens.org/health/g/gilberts-syndrome

  There is no special treatment for Gilbert’s Syndrome. Most of the time, the jaundice doesn’t make people sick. However, it is important to tell all your child’s doctors they have it. Some medicines might have worse side effects in people with Gilbert’s Syndrome, so it is important to tell your doctor about all medicines they take including supplements. […] It is safe to breastfeed a child with Gilbert’s Syndrome, even if it makes their jaundice last longer. There are no food restrictions with this condition.

• #24 Gilbert’s syndrome and antiviral therapy of hepatitis C | Annals of Hepatology

  https://www.elsevier.es/en-revista-annals-hepatology-16-articulo-gilberts-syndrome-antiviral-therapy-hepatitis-S1665268119317740

  Treatment of chronic hepatitis C with type I interferons and ribavirin can be associated with exacerbation of hepatitis and sometimes liver decompensation. […] A genetic disposition for Gilberts syndrome explained the adverse events and permitted a continuation of therapy leading to a sustained clearance of chronic hepatitis C infection. […] Based on the hypothesis of Gilberts associated unconjugated hyperbilirubinemia in the absence of inflammatory exacerbation or a deterioration of hepatic function antiviral treatment was continued. […] In conclusion, IFN-alfa and ribavirin therapy can induce severe unconjugated hyperbilirubinaemia in patients with Gilberts syndrome, which is linked to ribavirin. Continuation of therapy is possible, safe and effective in these individuals. Hyperbilirubinemia was observed to improve during the course of continued therapy. In unexpected hyperbilirubinemia during the initial phase of antiviral therapy determination of unconjugated bilirubin and genotyping for UGT1A1*28 is suggested for the decision to continue therapy.

• #25 Gastroenterologist for Gilbert syndrome, Symptoms, Treatment | mfine

  https://www.mfine.co/gastroenterologists/conditions/gilbert-syndrome/

  Gilberts syndrome does not require treatment usually. The bilirubin levels may fluctuate over time and occasionally leads to jaundice. Self-care: Certain life events like stress can trigger episodes of high bilirubin levels leading to jaundice. These lifestyle modifications can help you keep bilirubin levels under control: Eat a healthy diet Drink plenty of liquids Manage stress Limit your alcoholic intake Take blood tests to keep a check on your bilirubin levels […] Medications: Gilberts syndrome does not require treatment. The bilirubin levels may fluctuate over time and occasionally leads to jaundice. The symptoms can resolve on its own within a few days. […] Specialists: A primary care physician can help manage Gilbert’s syndrome. mfine provides you access to the best medical specialists for an integrated treatment plan to resolve all your health issues effectively.

• #26 Gilberts Syndrome – Liver Foundation

  https://liver.org.au/your-liver/liver-diseases/gilberts-syndrome/

  No treatment is needed for Gilbert’s syndrome. You may have jaundice now and then, but it will normally clear up by itself. […] If the jaundice is worse than normal, it’s worth checking in with your doctor. They may want to make sure there are no other liver conditions causing the jaundice.

• #27 Gilbert’s syndrome – British Liver Trust

  https://britishlivertrust.org.uk/information-and-support/liver-conditions/gilberts-syndrome/

  Most people will not need any treatment. […] If you have more serious symptoms, it is important to have more tests. It is possible to have another condition at the same time as Gilberts syndrome.

• #28 Gilbert’s Syndrome: Causes, Symptoms, and Treatment

  https://patient.info/digestive-health/abnormal-liver-function-tests-leaflet/gilberts-syndrome

  Gilbert’s syndrome is harmless and does not require treatment. […] No treatment is needed. People with Gilbert’s syndrome can lead normal, healthy lives. Life expectancy is not affected and life insurance is not affected. There is even some evidence that people with Gilbert’s syndrome live longer and are healthier than people who don’t have it. Mild yellowing of skin and the whites of the eyes (jaundice) may come back from time to time for short periods but usually causes no health problems. […] The take home message is – Gilbert’s syndrome is really a mild abnormality of how the liver processes a chemical (enzyme) called bilirubin. It is not really a 'disease’ and does not normally cause problems.

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