Materiały źródłowe

• #1 Gilbert Syndrome – StatPearls – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK470200/

  Gilbert syndrome is a common genetic disorder affecting bilirubin metabolism in the liver. This autosomal recessive condition leads to mild to moderate unconjugated hyperbilirubinemia, often presenting as recurrent episodes of jaundice. […] The prognosis for individuals with Gilbert syndrome is excellent, and the condition does not lead to significant liver disease. However, patients with Gilbert syndrome may have an increased risk of drug toxicity when exposed to medications that affect bilirubin metabolism. […] Patients with Gilbert syndrome typically have normal liver function tests aside from elevated unconjugated bilirubin levels. The condition is generally asymptomatic and does not require treatment, but several factors, including fasting, illness, menstruation, and dehydration, may trigger symptoms.

• #2 Gilbert Syndrome – StatPearls – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK470200/

  The prognosis of patients with Gilbert syndrome is excellent. […] Patients with Gilbert syndrome do not require treatment. Therefore, management primarily consists of reassuring patients and their families that this is a benign condition that does not require further testing. […] Gilbert syndrome is a benign, autosomal recessive inherited disorder of bilirubin metabolism. […] Patients are at an increased risk for more severe drug interactions, the development of pigmented gallstones, and more severe jaundice during the neonatal age, as well as in individuals with coexisting hemolytic diseases. […] Patients with this disease are not at risk for progressive liver disease, hepatic decompensation, or liver-related mortality. […] Patients and their families should be informed of the disease’s inherited and benign nature, and unnecessary testing should be avoided.

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• #4 Gilbert syndrome – Symptoms & causes – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/gilberts-syndrome/symptoms-causes/syc-20372811

  The most frequent sign of Gilbert syndrome is an occasional yellowish tinge of the skin and the whites of the eyes as a result of slightly higher levels of bilirubin in the blood. […] In people with Gilbert syndrome, bilirubin levels may increase due to: […] Illness, such as a cold or the flu […] Fasting or eating a very low-calorie diet […] Dehydration […] Menstruation […] Strenuous exercise […] Stress.

• #5 Gilbert’s Syndrome: Symptoms, Causes, Tests & Treatment

  https://my.clevelandclinic.org/health/diseases/17661-gilberts-syndrome

  People with Gilbert’s syndrome inherit a mutated gene that affects the livers ability to process bilirubin, a waste product that forms during the breakdown of old red blood cells. Jaundice (yellowish skin and eyes) occurs when too much bilirubin builds up in blood. Because this liver disease doesnt cause serious problems, treatment isnt necessary. […] Approximately 1 in 3 people with Gilbert’s syndrome dont have symptoms. They learn that they have the disease after getting blood tests to check for a different problem. […] Among those with symptoms, the most common sign is jaundice, brought on by elevated levels of bilirubin in blood. Jaundice can turn your skin and whites of the eyes yellow, but it isnt harmful. […] Occasionally, people who have jaundice or Gilbert’s syndrome also experience: Dark-colored urine or clay-colored stool. Difficulty concentrating. Dizziness. Gastrointestinal problems, such as abdominal pain, diarrhea and nausea. Fatigue. Flu-like symptoms, including fever and chills. Loss of appetite.

• #6 Gilbert’s Syndrome: Symptoms, Causes, Tests & Treatment

  https://my.clevelandclinic.org/health/diseases/17661-gilberts-syndrome

  People with Gilbert’s syndrome inherit a mutated gene that affects the livers ability to process bilirubin, a waste product that forms during the breakdown of old red blood cells. Jaundice (yellowish skin and eyes) occurs when too much bilirubin builds up in blood. Because this liver disease doesnt cause serious problems, treatment isnt necessary. […] Approximately 1 in 3 people with Gilbert’s syndrome dont have symptoms. They learn that they have the disease after getting blood tests to check for a different problem. […] Among those with symptoms, the most common sign is jaundice, brought on by elevated levels of bilirubin in blood. Jaundice can turn your skin and whites of the eyes yellow, but it isnt harmful. […] Occasionally, people who have jaundice or Gilbert’s syndrome also experience: Dark-colored urine or clay-colored stool. Difficulty concentrating. Dizziness. Gastrointestinal problems, such as abdominal pain, diarrhea and nausea. Fatigue. Flu-like symptoms, including fever and chills. Loss of appetite.

• #7 Gilbert’s syndrome | nidirect

  https://www.nidirect.gov.uk/conditions/gilberts-syndrome

  Most people with Gilbert’s syndrome experience occasional and short-lived episodes of jaundice (yellowing of the skin and whites of the eyes) due to the build-up of bilirubin in the blood. […] As Gilbert’s syndrome usually only causes a slight increase in bilirubin levels, the yellowing of jaundice is often mild. The eyes are usually affected most. […] Some people also report other problems during episodes of jaundice, including: abdominal (tummy) pain, feeling very tired (fatigue), loss of appetite, feeling sick, dizziness, irritable bowel syndrome (IBS), problems concentrating and thinking clearly (brain fog), and a general sense of feeling unwell. […] Around one in three people with Gilberts syndrome don’t experience any symptoms at all. […] Episodes of jaundice and any associated symptoms are usually short-lived and eventually pass.

• #8 Azthena logo with the word Azthena

  https://www.news-medical.net/health/Symptoms-of-Gilberts-Syndrome.aspx

  Gilberts syndrome occurs in 1 in 20 individuals. This syndrome is characterized by jaundice. However, there is a large population of sufferers who are not aware of their condition. […] The symptoms of Gilberts syndrome include jaundice, tiredness and sometimes no symptoms at all. […] Patients with Gilberts syndrome are prone to develop jaundice from time to time. The risk increases with other problems like starvation, dehydration, repeated and profuse vomiting, infections, exertion and stress and after a surgery. […] Other symptoms of Gilberts syndrome include: tiredness, mild weakness and fatigue, mild abdominal pains especially in the upper abdomen, mild nausea and sometimes vomiting, severe loss of appetite, intolerance to fat, dizziness, irritable bowel syndrome, difficulty in concentrating or focussing on tasks at hand etc. […] Most patients present without any symptom of the condition. These patients may or may not have intermittent rise of bilirubin leading to symptoms of jaundice. At least 30% of patients with Gilberts syndrome have this silent condition with no symptom whatsoever.

• #9 Gilbert’s syndrome — Symptoms, causes and management | healthdirect

  https://www.healthdirect.gov.au/gilberts-syndrome

  Gilbert’s syndrome is a mild liver disorder. […] If bilirubin is not broken down, it can build up in your blood and can cause your eyes and skin to yellow (jaundice). […] Jaundice caused by Gilbert’s syndrome usually clears by itself without treatment. […] Most people with Gilbert’s syndrome do not have any symptoms. […] In some people, it causes yellowing of the eyes and skin (jaundice), due to higher levels of bilirubin in the blood. […] It’s normal for your bilirubin levels to vary over time. If you have Gilbert’s syndrome, they may go up or down when you are: sick or have an infection, fasting, during menstruation (your period). […] Newborns are sometimes born with jaundice. Babies with Gilbert’s syndrome may have higher levels of bilirubin and take longer to recover from jaundice.

• #10 Gilbert syndrome: Symptoms, diet, and treatment

  https://www.medicalnewstoday.com/articles/166971

  Mild jaundice is the only sign that a person has Gilbert syndrome. […] Many people with Gilbert syndrome have no symptoms. Around 30 percent find out they have it by chance through routine tests. […] If a person has too much bilirubin, they will have jaundice, a yellow tinge to the whites of the eyes. The skin, too, can take on a yellowish tinge, if levels rise further. […] A person with Gilberts syndrome is unlikely to have specific symptoms, beyond some yellowing of the eyes. […] Some people may experience fatigue and abdominal discomfort, but experts have made no connection between higher bilirubin levels and these symptoms. […] Bilirubin levels do not reach very high levels with Gilberts syndrome, but the jaundice can be disturbing.

• #11 Gilbert’s Syndrome: Symptoms, Causes, Tests & Treatment

  https://my.clevelandclinic.org/health/diseases/17661-gilberts-syndrome

  People with Gilbert’s syndrome inherit a mutated gene that affects the livers ability to process bilirubin, a waste product that forms during the breakdown of old red blood cells. Jaundice (yellowish skin and eyes) occurs when too much bilirubin builds up in blood. Because this liver disease doesnt cause serious problems, treatment isnt necessary. […] Approximately 1 in 3 people with Gilbert’s syndrome dont have symptoms. They learn that they have the disease after getting blood tests to check for a different problem. […] Among those with symptoms, the most common sign is jaundice, brought on by elevated levels of bilirubin in blood. Jaundice can turn your skin and whites of the eyes yellow, but it isnt harmful. […] Occasionally, people who have jaundice or Gilbert’s syndrome also experience: Dark-colored urine or clay-colored stool. Difficulty concentrating. Dizziness. Gastrointestinal problems, such as abdominal pain, diarrhea and nausea. Fatigue. Flu-like symptoms, including fever and chills. Loss of appetite.

• #12 Gilbert’s syndrome | nidirect

  https://www.nidirect.gov.uk/conditions/gilberts-syndrome

  Most people with Gilbert’s syndrome experience occasional and short-lived episodes of jaundice (yellowing of the skin and whites of the eyes) due to the build-up of bilirubin in the blood. […] As Gilbert’s syndrome usually only causes a slight increase in bilirubin levels, the yellowing of jaundice is often mild. The eyes are usually affected most. […] Some people also report other problems during episodes of jaundice, including: abdominal (tummy) pain, feeling very tired (fatigue), loss of appetite, feeling sick, dizziness, irritable bowel syndrome (IBS), problems concentrating and thinking clearly (brain fog), and a general sense of feeling unwell. […] Around one in three people with Gilberts syndrome don’t experience any symptoms at all. […] Episodes of jaundice and any associated symptoms are usually short-lived and eventually pass.

• #13 Gilbert’s syndrome | Better Health Channel

  https://www.betterhealth.vic.gov.au/health/conditionsandtreatments/gilberts-syndrome

  Gilberts syndrome is characterised by the livers inability to process the yellowish-brown pigment in bile (bilirubin). […] Too much bilirubin can cause yellowing of the skin and eyes (jaundice). […] Gilberts syndrome typically has no obvious symptoms, other than yellowing of the skin or eyes (jaundice). Other symptoms are sometimes reported, including: gastrointestinal complaints, fatigue, weakness, abdominal pain. […] However, it is not clear that these symptoms are directly related to higher levels of bilirubin. […] In a person with Gilberts syndrome, the bilirubin levels typically fluctuate and only sometimes hover within the normal range. […] Gilberts syndrome is a mild disorder that typically doesnt need medical treatment. People with the disorder lead normal, healthy lives. There is no evidence to suggest that the condition is harmful or leads to more serious diseases.

• #14 Gilbert’s syndrome | Better Health Channel

  https://www.betterhealth.vic.gov.au/health/conditionsandtreatments/gilberts-syndrome

  Gilberts syndrome is characterised by the livers inability to process the yellowish-brown pigment in bile (bilirubin). […] Too much bilirubin can cause yellowing of the skin and eyes (jaundice). […] Gilberts syndrome typically has no obvious symptoms, other than yellowing of the skin or eyes (jaundice). Other symptoms are sometimes reported, including: gastrointestinal complaints, fatigue, weakness, abdominal pain. […] However, it is not clear that these symptoms are directly related to higher levels of bilirubin. […] In a person with Gilberts syndrome, the bilirubin levels typically fluctuate and only sometimes hover within the normal range. […] Gilberts syndrome is a mild disorder that typically doesnt need medical treatment. People with the disorder lead normal, healthy lives. There is no evidence to suggest that the condition is harmful or leads to more serious diseases.

• #15 Gilbert’s Syndrome | Symptoms, Diagnosis & Treatment

  https://www.cincinnatichildrens.org/health/g/gilberts-syndrome

  Most people do not have symptoms. Sometimes people will have jaundice. Jaundice is when the skin or the whites of the eyes turn yellow. Jaundice most often occurs when the body is stressed, like when you have a fever, hard exercise, or not eating/drinking enough. […] Newborn babies are at risk for jaundice already. Gilbert’s Syndrome can cause newborn babies to have jaundice for longer than other babies. […] This is a safe condition that does not cause any significant harm throughout ones life.

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• #17 Gilbert’s Syndrome: Causes, Symptoms, and Treatment

  https://patient.info/digestive-health/abnormal-liver-function-tests-leaflet/gilberts-syndrome

  Gilbert’s syndrome is due to an inherited defect in processing bilirubin in the liver. This can cause mild jaundice from time to time and can also be seen as slightly raised bilirubin levels on a blood test. Gilbert’s syndrome symptoms […] The level of bilirubin in the blood goes up and down. However, this does not usually cause any problems as the level does not go very high. […] If the level of bilirubin goes above a certain level you can develop yellowing of skin and the whites of your eyes. This is because bilirubin is an orangy-yellow colour. This condition is called jaundice. Some people with Gilbert’s syndrome experience mild episodes of jaundice from time to time. […] The jaundice itself does not usually cause any problems. However, some people with Gilbert’s syndrome report other symptoms – most commonly: Tiredness, Mild weakness, Mild tummy (abdominal) pains, A mild feeling of sickness (nausea). […] It is not clear whether these symptoms are actually related to Gilbert’s syndrome. There does not seem to be any relationship between these symptoms and the level of bilirubin in the blood.

• #18 Gilbert Syndrome: Causes, Symptoms, and More

  https://www.webmd.com/children/what-is-gilbert-syndrome

  Most people with Gilberts syndrome don’t have symptoms. They have enough of the liver enzyme to control their bilirubin levels. […] When bilirubin does build up in the blood, it causes the skin and whites of the eyes to turn yellow. This is called jaundice. See your doctor if you notice a yellow color to your skin and eyes because another condition could be causing it. […] Jaundice can cause other symptoms such as: Nausea and diarrhea, Abdominal discomfort, Fatigue, Dark urine. […] Jaundice is a common problem in babies. But its worse in babies born with Gilberts syndrome. Certain things can make your bilirubin levels rise, but you might only notice jaundice when you: Are stressed, Are dehydrated, Exercise too much, Have an infection like the flu, Skip meals, Drink alcohol, Take medicines that affect your liver, Are outside in cold weather, Have your period, Are recovering from surgery.

• #19 Gilbert Syndrome – Causes, Symptoms, Diagnosis, and Treatment PACE Hospitals – Best Hospitals in Hitech City, Hyderabad, India | Near Madhapur, Kukatpally, KPHB, Kondapur, Gachibowli, Jubilee Hills, Banjara HillsPACE Hospitals Contact Num

  https://www.pacehospital.com/gilbert-syndrome-causes-symptoms-diagnosis-treatment

  Many patients with Gilbert syndrome may experience occasional or short-lived episodes of jaundice (yellowing of the whites of eyes and skin) due to the buildup of high levels of bilirubin. The yellowing due to jaundice is mild, as Gilbert syndrome causes a slight increase in bilirubin. Some people may experience other symptoms during episodes of jaundice such as: […] Pain in abdomen […] Fatigue (tiredness) […] Loss of appetite […] Dizziness […] Feeling sick […] Symptoms of Irritable bowel syndrome (IBS) […] Individuals with Gilbert syndrome often find that there are few triggers or risk factors that can bring jaundice episodes. Risk factors or triggers that can increase the risk of hyperbilirubinemia (increased levels of bilirubin in blood) include: […] Fasting: Intermittent fasting causes a 2-3-fold increase in unconjugated bilirubin in individuals with Gilbert syndrome.

• #20 Gilbert’s syndrome | nidirect

  https://www.nidirect.gov.uk/conditions/gilberts-syndrome

  Most people with Gilbert’s syndrome experience occasional and short-lived episodes of jaundice (yellowing of the skin and whites of the eyes) due to the build-up of bilirubin in the blood. […] As Gilbert’s syndrome usually only causes a slight increase in bilirubin levels, the yellowing of jaundice is often mild. The eyes are usually affected most. […] Some people also report other problems during episodes of jaundice, including: abdominal (tummy) pain, feeling very tired (fatigue), loss of appetite, feeling sick, dizziness, irritable bowel syndrome (IBS), problems concentrating and thinking clearly (brain fog), and a general sense of feeling unwell. […] Around one in three people with Gilberts syndrome don’t experience any symptoms at all. […] Episodes of jaundice and any associated symptoms are usually short-lived and eventually pass.

• #21

• #22 Azthena logo with the word Azthena

  https://www.news-medical.net/health/Symptoms-of-Gilberts-Syndrome.aspx

  Gilberts syndrome occurs in 1 in 20 individuals. This syndrome is characterized by jaundice. However, there is a large population of sufferers who are not aware of their condition. […] The symptoms of Gilberts syndrome include jaundice, tiredness and sometimes no symptoms at all. […] Patients with Gilberts syndrome are prone to develop jaundice from time to time. The risk increases with other problems like starvation, dehydration, repeated and profuse vomiting, infections, exertion and stress and after a surgery. […] Other symptoms of Gilberts syndrome include: tiredness, mild weakness and fatigue, mild abdominal pains especially in the upper abdomen, mild nausea and sometimes vomiting, severe loss of appetite, intolerance to fat, dizziness, irritable bowel syndrome, difficulty in concentrating or focussing on tasks at hand etc. […] Most patients present without any symptom of the condition. These patients may or may not have intermittent rise of bilirubin leading to symptoms of jaundice. At least 30% of patients with Gilberts syndrome have this silent condition with no symptom whatsoever.

• #23 Gilbert’s Syndrome: Symptoms, Causes, Tests & Treatment

  https://my.clevelandclinic.org/health/diseases/17661-gilberts-syndrome

  People with Gilbert’s syndrome inherit a mutated gene that affects the livers ability to process bilirubin, a waste product that forms during the breakdown of old red blood cells. Jaundice (yellowish skin and eyes) occurs when too much bilirubin builds up in blood. Because this liver disease doesnt cause serious problems, treatment isnt necessary. […] Approximately 1 in 3 people with Gilbert’s syndrome dont have symptoms. They learn that they have the disease after getting blood tests to check for a different problem. […] Among those with symptoms, the most common sign is jaundice, brought on by elevated levels of bilirubin in blood. Jaundice can turn your skin and whites of the eyes yellow, but it isnt harmful. […] Occasionally, people who have jaundice or Gilbert’s syndrome also experience: Dark-colored urine or clay-colored stool. Difficulty concentrating. Dizziness. Gastrointestinal problems, such as abdominal pain, diarrhea and nausea. Fatigue. Flu-like symptoms, including fever and chills. Loss of appetite.

• #24 Gilbert’s syndrome | nidirect

  https://www.nidirect.gov.uk/conditions/gilberts-syndrome

  Most people with Gilbert’s syndrome experience occasional and short-lived episodes of jaundice (yellowing of the skin and whites of the eyes) due to the build-up of bilirubin in the blood. […] As Gilbert’s syndrome usually only causes a slight increase in bilirubin levels, the yellowing of jaundice is often mild. The eyes are usually affected most. […] Some people also report other problems during episodes of jaundice, including: abdominal (tummy) pain, feeling very tired (fatigue), loss of appetite, feeling sick, dizziness, irritable bowel syndrome (IBS), problems concentrating and thinking clearly (brain fog), and a general sense of feeling unwell. […] Around one in three people with Gilberts syndrome don’t experience any symptoms at all. […] Episodes of jaundice and any associated symptoms are usually short-lived and eventually pass.

• #25 Gilbert Syndrome: Symptoms & Complications

  https://liverfoundation.org/liver-diseases/rare-disease/gilbert-syndrome/

  Gilbert Syndrome is a mild genetic disorder in which the liver does not properly process a substance called bilirubin. Bilirubin is made by the break down of red blood cells. […] Gilbert Syndrome affects three to seven percent of people in the United States. Gilbert Syndrome is more common in men than women. […] Individuals with Gilbert Syndrome have elevated levels of bilirubin (hyperbilirubinemia), because they have a reduced level of a specific liver enzyme required for elimination of bilirubin. […] People with Gilbert Syndrome usually do not have symptoms. Gilbert Syndrome sometimes causes the liver to make too much bilirubin that the person becomes jaundiced (yellowing of eyes and skin). […] Certain things can further increase the level of bilirubin in the bodies of those with Gilbert Syndrome: Being ill, Menstruating, Fasting or skipping meals, Exercising too much. […] Complications of Gilbert Syndrome may include certain medications causing side effects in people who have Gilbert Syndrome. Talk to a doctor before taking any new medications. […] Since Gilbert Syndrome is a mild and manageable condition, it does not need treatment.

• #26 Gilbert’s Syndrome: Symptoms, Causes, Tests & Treatment

  https://my.clevelandclinic.org/health/diseases/17661-gilberts-syndrome

  People with Gilbert’s syndrome inherit a mutated gene that affects the livers ability to process bilirubin, a waste product that forms during the breakdown of old red blood cells. Jaundice (yellowish skin and eyes) occurs when too much bilirubin builds up in blood. Because this liver disease doesnt cause serious problems, treatment isnt necessary. […] Approximately 1 in 3 people with Gilbert’s syndrome dont have symptoms. They learn that they have the disease after getting blood tests to check for a different problem. […] Among those with symptoms, the most common sign is jaundice, brought on by elevated levels of bilirubin in blood. Jaundice can turn your skin and whites of the eyes yellow, but it isnt harmful. […] Occasionally, people who have jaundice or Gilbert’s syndrome also experience: Dark-colored urine or clay-colored stool. Difficulty concentrating. Dizziness. Gastrointestinal problems, such as abdominal pain, diarrhea and nausea. Fatigue. Flu-like symptoms, including fever and chills. Loss of appetite.

• #27

  https://www.cbsnews.com/news/gilbert-syndrome-symptoms-treatment-bachelor-star-joey-graziadei/

  After receiving comments and questions about his „yellow eyes,” „Bachelor” star Joey Graziadei took to social media Thursday to reveal he has Gilbert syndrome, a liver condition that can affect the color of your skin and eyes. […] Gilbert syndrome is an inherited disorder that „affects the liver’s ability to process bilirubin, a waste product that forms during the breakdown of old red blood cells,” the Cleveland Clinic explains. When too much bilirubin builds up in the blood, jaundice or yellowish skin and eyes can occur. […] In addition to yellowing of the skin or eyes, the Cleveland Clinic says people who have jaundice or Gilbert’s syndrome also may experience: Dark-colored urine or clay-colored stool, Difficulty concentrating, Dizziness, Gastrointestinal problems, Fatigue, Flu-like symptoms, Loss of appetite.

• #28 Gilbert’s syndrome | nidirect

  https://www.nidirect.gov.uk/conditions/gilberts-syndrome

  Most people with Gilbert’s syndrome experience occasional and short-lived episodes of jaundice (yellowing of the skin and whites of the eyes) due to the build-up of bilirubin in the blood. […] As Gilbert’s syndrome usually only causes a slight increase in bilirubin levels, the yellowing of jaundice is often mild. The eyes are usually affected most. […] Some people also report other problems during episodes of jaundice, including: abdominal (tummy) pain, feeling very tired (fatigue), loss of appetite, feeling sick, dizziness, irritable bowel syndrome (IBS), problems concentrating and thinking clearly (brain fog), and a general sense of feeling unwell. […] Around one in three people with Gilberts syndrome don’t experience any symptoms at all. […] Episodes of jaundice and any associated symptoms are usually short-lived and eventually pass.

• #29 Gilbert Syndrome – Causes, Symptoms, Diagnosis, and Treatment PACE Hospitals – Best Hospitals in Hitech City, Hyderabad, India | Near Madhapur, Kukatpally, KPHB, Kondapur, Gachibowli, Jubilee Hills, Banjara HillsPACE Hospitals Contact Num

  https://www.pacehospital.com/gilbert-syndrome-causes-symptoms-diagnosis-treatment

  Many patients with Gilbert syndrome may experience occasional or short-lived episodes of jaundice (yellowing of the whites of eyes and skin) due to the buildup of high levels of bilirubin. The yellowing due to jaundice is mild, as Gilbert syndrome causes a slight increase in bilirubin. Some people may experience other symptoms during episodes of jaundice such as: […] Pain in abdomen […] Fatigue (tiredness) […] Loss of appetite […] Dizziness […] Feeling sick […] Symptoms of Irritable bowel syndrome (IBS) […] Individuals with Gilbert syndrome often find that there are few triggers or risk factors that can bring jaundice episodes. Risk factors or triggers that can increase the risk of hyperbilirubinemia (increased levels of bilirubin in blood) include: […] Fasting: Intermittent fasting causes a 2-3-fold increase in unconjugated bilirubin in individuals with Gilbert syndrome.

• #30 Gilbert’s Syndrome: Symptoms, Causes, Tests & Treatment

  https://my.clevelandclinic.org/health/diseases/17661-gilberts-syndrome

  People with Gilbert’s syndrome inherit a mutated gene that affects the livers ability to process bilirubin, a waste product that forms during the breakdown of old red blood cells. Jaundice (yellowish skin and eyes) occurs when too much bilirubin builds up in blood. Because this liver disease doesnt cause serious problems, treatment isnt necessary. […] Approximately 1 in 3 people with Gilbert’s syndrome dont have symptoms. They learn that they have the disease after getting blood tests to check for a different problem. […] Among those with symptoms, the most common sign is jaundice, brought on by elevated levels of bilirubin in blood. Jaundice can turn your skin and whites of the eyes yellow, but it isnt harmful. […] Occasionally, people who have jaundice or Gilbert’s syndrome also experience: Dark-colored urine or clay-colored stool. Difficulty concentrating. Dizziness. Gastrointestinal problems, such as abdominal pain, diarrhea and nausea. Fatigue. Flu-like symptoms, including fever and chills. Loss of appetite.

• #31

  https://www.cbsnews.com/news/gilbert-syndrome-symptoms-treatment-bachelor-star-joey-graziadei/

  After receiving comments and questions about his „yellow eyes,” „Bachelor” star Joey Graziadei took to social media Thursday to reveal he has Gilbert syndrome, a liver condition that can affect the color of your skin and eyes. […] Gilbert syndrome is an inherited disorder that „affects the liver’s ability to process bilirubin, a waste product that forms during the breakdown of old red blood cells,” the Cleveland Clinic explains. When too much bilirubin builds up in the blood, jaundice or yellowish skin and eyes can occur. […] In addition to yellowing of the skin or eyes, the Cleveland Clinic says people who have jaundice or Gilbert’s syndrome also may experience: Dark-colored urine or clay-colored stool, Difficulty concentrating, Dizziness, Gastrointestinal problems, Fatigue, Flu-like symptoms, Loss of appetite.

• #32 Gilbert syndrome – Symptoms & causes – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/gilberts-syndrome/symptoms-causes/syc-20372811

  The most frequent sign of Gilbert syndrome is an occasional yellowish tinge of the skin and the whites of the eyes as a result of slightly higher levels of bilirubin in the blood. […] In people with Gilbert syndrome, bilirubin levels may increase due to: […] Illness, such as a cold or the flu […] Fasting or eating a very low-calorie diet […] Dehydration […] Menstruation […] Strenuous exercise […] Stress.

• #33 Patient education: Gilbert syndrome (Beyond the Basics) – UpToDate

  https://www.uptodate.com/contents/gilbert-syndrome-beyond-the-basics/print

  Levels of bilirubin can fluctuate in people with Gilbert syndrome. They may be highest during an infection (such as the flu), following periods of fasting, and during menstrual periods in some women. In addition, newborns with Gilbert syndrome may have higher levels of bilirubin and more persistent jaundice than newborns without. […] Gilbert syndrome may also become apparent when an affected person takes certain drugs that require the enzyme involved in bilirubin processing in the liver. A cancer drug called irinotecan is one example.

• #34 Gilbert Syndrome – Causes, Symptoms, Diagnosis, and Treatment PACE Hospitals – Best Hospitals in Hitech City, Hyderabad, India | Near Madhapur, Kukatpally, KPHB, Kondapur, Gachibowli, Jubilee Hills, Banjara HillsPACE Hospitals Contact Num

  https://www.pacehospital.com/gilbert-syndrome-causes-symptoms-diagnosis-treatment

  Many patients with Gilbert syndrome may experience occasional or short-lived episodes of jaundice (yellowing of the whites of eyes and skin) due to the buildup of high levels of bilirubin. The yellowing due to jaundice is mild, as Gilbert syndrome causes a slight increase in bilirubin. Some people may experience other symptoms during episodes of jaundice such as: […] Pain in abdomen […] Fatigue (tiredness) […] Loss of appetite […] Dizziness […] Feeling sick […] Symptoms of Irritable bowel syndrome (IBS) […] Individuals with Gilbert syndrome often find that there are few triggers or risk factors that can bring jaundice episodes. Risk factors or triggers that can increase the risk of hyperbilirubinemia (increased levels of bilirubin in blood) include: […] Fasting: Intermittent fasting causes a 2-3-fold increase in unconjugated bilirubin in individuals with Gilbert syndrome.

• #35 Gilbert syndrome – Symptoms & causes – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/gilberts-syndrome/symptoms-causes/syc-20372811

  The most frequent sign of Gilbert syndrome is an occasional yellowish tinge of the skin and the whites of the eyes as a result of slightly higher levels of bilirubin in the blood. […] In people with Gilbert syndrome, bilirubin levels may increase due to: […] Illness, such as a cold or the flu […] Fasting or eating a very low-calorie diet […] Dehydration […] Menstruation […] Strenuous exercise […] Stress.

• #36 Gilbert Syndrome – Causes, Symptoms, Diagnosis, and Treatment PACE Hospitals – Best Hospitals in Hitech City, Hyderabad, India | Near Madhapur, Kukatpally, KPHB, Kondapur, Gachibowli, Jubilee Hills, Banjara HillsPACE Hospitals Contact Num

  https://www.pacehospital.com/gilbert-syndrome-causes-symptoms-diagnosis-treatment

  Being dehydrated: Bilirubin levels increase following dehydration. […] Excessive alcohol consumption: Excessive consumption of alcohol increases bilirubin levels. […] Being ill due to an infection: Bilirubin levels increase following any illness […] Heavy physical exercise: Extreme physical activity and stress trigger hyperbilirubinemia […] Menstruation: Menstruation causes fluctuation in bilirubin levels […] Surgery: In patients who have undergone surgery, bilirubin levels may raise temporarily […] Inadequate sleep: Lack of sleep is considered a form of stress that can increase bilirubin production. […] It is a benign, autosomal recessive inherited disorder that affects the metabolism of bilirubin. Individuals with Gilbert syndrome are at increased risk for the following: […] Severe drug interactions […] Pigmented gallstones development […] Severe jaundice during neonatal age as well as in patients with coexisting hemolytic disease. […] There are no proven complications of Gilbert syndrome. It is not a risk for progressive liver disease or liver related mortality.

• #37 Gilbert syndrome – Symptoms & causes – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/gilberts-syndrome/symptoms-causes/syc-20372811

  The most frequent sign of Gilbert syndrome is an occasional yellowish tinge of the skin and the whites of the eyes as a result of slightly higher levels of bilirubin in the blood. […] In people with Gilbert syndrome, bilirubin levels may increase due to: […] Illness, such as a cold or the flu […] Fasting or eating a very low-calorie diet […] Dehydration […] Menstruation […] Strenuous exercise […] Stress.

• #38 Gilbert Syndrome – Causes, Symptoms, Diagnosis, and Treatment PACE Hospitals – Best Hospitals in Hitech City, Hyderabad, India | Near Madhapur, Kukatpally, KPHB, Kondapur, Gachibowli, Jubilee Hills, Banjara HillsPACE Hospitals Contact Num

  https://www.pacehospital.com/gilbert-syndrome-causes-symptoms-diagnosis-treatment

  Many patients with Gilbert syndrome may experience occasional or short-lived episodes of jaundice (yellowing of the whites of eyes and skin) due to the buildup of high levels of bilirubin. The yellowing due to jaundice is mild, as Gilbert syndrome causes a slight increase in bilirubin. Some people may experience other symptoms during episodes of jaundice such as: […] Pain in abdomen […] Fatigue (tiredness) […] Loss of appetite […] Dizziness […] Feeling sick […] Symptoms of Irritable bowel syndrome (IBS) […] Individuals with Gilbert syndrome often find that there are few triggers or risk factors that can bring jaundice episodes. Risk factors or triggers that can increase the risk of hyperbilirubinemia (increased levels of bilirubin in blood) include: […] Fasting: Intermittent fasting causes a 2-3-fold increase in unconjugated bilirubin in individuals with Gilbert syndrome.

• #39 Gilbert syndrome – Symptoms & causes – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/gilberts-syndrome/symptoms-causes/syc-20372811

  The most frequent sign of Gilbert syndrome is an occasional yellowish tinge of the skin and the whites of the eyes as a result of slightly higher levels of bilirubin in the blood. […] In people with Gilbert syndrome, bilirubin levels may increase due to: […] Illness, such as a cold or the flu […] Fasting or eating a very low-calorie diet […] Dehydration […] Menstruation […] Strenuous exercise […] Stress.

• #40 Gilbert Syndrome – Causes, Symptoms, Diagnosis, and Treatment PACE Hospitals – Best Hospitals in Hitech City, Hyderabad, India | Near Madhapur, Kukatpally, KPHB, Kondapur, Gachibowli, Jubilee Hills, Banjara HillsPACE Hospitals Contact Num

  https://www.pacehospital.com/gilbert-syndrome-causes-symptoms-diagnosis-treatment

  Being dehydrated: Bilirubin levels increase following dehydration. […] Excessive alcohol consumption: Excessive consumption of alcohol increases bilirubin levels. […] Being ill due to an infection: Bilirubin levels increase following any illness […] Heavy physical exercise: Extreme physical activity and stress trigger hyperbilirubinemia […] Menstruation: Menstruation causes fluctuation in bilirubin levels […] Surgery: In patients who have undergone surgery, bilirubin levels may raise temporarily […] Inadequate sleep: Lack of sleep is considered a form of stress that can increase bilirubin production. […] It is a benign, autosomal recessive inherited disorder that affects the metabolism of bilirubin. Individuals with Gilbert syndrome are at increased risk for the following: […] Severe drug interactions […] Pigmented gallstones development […] Severe jaundice during neonatal age as well as in patients with coexisting hemolytic disease. […] There are no proven complications of Gilbert syndrome. It is not a risk for progressive liver disease or liver related mortality.

• #41 Gilbert syndrome – Symptoms & causes – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/gilberts-syndrome/symptoms-causes/syc-20372811

  The most frequent sign of Gilbert syndrome is an occasional yellowish tinge of the skin and the whites of the eyes as a result of slightly higher levels of bilirubin in the blood. […] In people with Gilbert syndrome, bilirubin levels may increase due to: […] Illness, such as a cold or the flu […] Fasting or eating a very low-calorie diet […] Dehydration […] Menstruation […] Strenuous exercise […] Stress.

• #42 Patient education: Gilbert syndrome (Beyond the Basics) – UpToDate

  https://www.uptodate.com/contents/gilbert-syndrome-beyond-the-basics/print

  Levels of bilirubin can fluctuate in people with Gilbert syndrome. They may be highest during an infection (such as the flu), following periods of fasting, and during menstrual periods in some women. In addition, newborns with Gilbert syndrome may have higher levels of bilirubin and more persistent jaundice than newborns without. […] Gilbert syndrome may also become apparent when an affected person takes certain drugs that require the enzyme involved in bilirubin processing in the liver. A cancer drug called irinotecan is one example.

• #43 Gilbert syndrome – Symptoms & causes – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/gilberts-syndrome/symptoms-causes/syc-20372811

  The most frequent sign of Gilbert syndrome is an occasional yellowish tinge of the skin and the whites of the eyes as a result of slightly higher levels of bilirubin in the blood. […] In people with Gilbert syndrome, bilirubin levels may increase due to: […] Illness, such as a cold or the flu […] Fasting or eating a very low-calorie diet […] Dehydration […] Menstruation […] Strenuous exercise […] Stress.

• #44 Gilbert Syndrome – Causes, Symptoms, Diagnosis, and Treatment PACE Hospitals – Best Hospitals in Hitech City, Hyderabad, India | Near Madhapur, Kukatpally, KPHB, Kondapur, Gachibowli, Jubilee Hills, Banjara HillsPACE Hospitals Contact Num

  https://www.pacehospital.com/gilbert-syndrome-causes-symptoms-diagnosis-treatment

  Being dehydrated: Bilirubin levels increase following dehydration. […] Excessive alcohol consumption: Excessive consumption of alcohol increases bilirubin levels. […] Being ill due to an infection: Bilirubin levels increase following any illness […] Heavy physical exercise: Extreme physical activity and stress trigger hyperbilirubinemia […] Menstruation: Menstruation causes fluctuation in bilirubin levels […] Surgery: In patients who have undergone surgery, bilirubin levels may raise temporarily […] Inadequate sleep: Lack of sleep is considered a form of stress that can increase bilirubin production. […] It is a benign, autosomal recessive inherited disorder that affects the metabolism of bilirubin. Individuals with Gilbert syndrome are at increased risk for the following: […] Severe drug interactions […] Pigmented gallstones development […] Severe jaundice during neonatal age as well as in patients with coexisting hemolytic disease. […] There are no proven complications of Gilbert syndrome. It is not a risk for progressive liver disease or liver related mortality.

• #45 Gilbert syndrome – Symptoms & causes – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/gilberts-syndrome/symptoms-causes/syc-20372811

  The most frequent sign of Gilbert syndrome is an occasional yellowish tinge of the skin and the whites of the eyes as a result of slightly higher levels of bilirubin in the blood. […] In people with Gilbert syndrome, bilirubin levels may increase due to: […] Illness, such as a cold or the flu […] Fasting or eating a very low-calorie diet […] Dehydration […] Menstruation […] Strenuous exercise […] Stress.

• #46 Gilbert’s syndrome | The London Clinic

  https://www.thelondonclinic.co.uk/services/conditions/gilberts-syndrome

  Physical and emotional stress can trigger Gilberts syndrome symptoms or make them worse. […] If you have Gilberts syndrome you may find it harder to recover from stress. You may find symptoms of tiredness and yellowing of the skin become more noticeable. […] Most people dont know they have Gilberts syndrome unless they develop jaundice where their skin or eyes start to yellow. […] If the test results show you have high levels of bilirubin in your blood, but your liver is working well, it confirms a positive diagnosis of Gilberts syndrome. […] There is no cure for Gilberts syndrome as it is caused by a specific gene in DNA, and this makes it a lifelong condition. […] Jaundice and Gilberts syndrome do not damage the liver or cause complications so theres no specific treatment for it. […] Episodes of jaundice are usually short lived and dont increase the risk of other serious conditions.

• #47 Gilbert Syndrome – Causes, Symptoms, Diagnosis, and Treatment PACE Hospitals – Best Hospitals in Hitech City, Hyderabad, India | Near Madhapur, Kukatpally, KPHB, Kondapur, Gachibowli, Jubilee Hills, Banjara HillsPACE Hospitals Contact Num

  https://www.pacehospital.com/gilbert-syndrome-causes-symptoms-diagnosis-treatment

  Being dehydrated: Bilirubin levels increase following dehydration. […] Excessive alcohol consumption: Excessive consumption of alcohol increases bilirubin levels. […] Being ill due to an infection: Bilirubin levels increase following any illness […] Heavy physical exercise: Extreme physical activity and stress trigger hyperbilirubinemia […] Menstruation: Menstruation causes fluctuation in bilirubin levels […] Surgery: In patients who have undergone surgery, bilirubin levels may raise temporarily […] Inadequate sleep: Lack of sleep is considered a form of stress that can increase bilirubin production. […] It is a benign, autosomal recessive inherited disorder that affects the metabolism of bilirubin. Individuals with Gilbert syndrome are at increased risk for the following: […] Severe drug interactions […] Pigmented gallstones development […] Severe jaundice during neonatal age as well as in patients with coexisting hemolytic disease. […] There are no proven complications of Gilbert syndrome. It is not a risk for progressive liver disease or liver related mortality.

• #48 Gilbert’s Syndrome Serum, Plasma Samples – Bay Biosciences

  https://baybiosciences.com/gilberts-syndrome-serum-plasma-samples/

  Gilberts syndrome can cause the following signs and symptoms: Abdominal Pain and discomfort, Clay colored stool, Cold and flu like symptoms, Dark colored urine, Diarrhea, Difficulty concentrating, Dizziness, Fatigue, Jaundice Loss of appetite, Nausea. […] The signs and symptoms get more exacerbate in patients with Gilberts syndrome due to some of the following conditions, that can further increase the bilirubin levels, such as: Being sick, Drinking alcohol (Alcohol can raise bilirubin levels in patients with Gilberts syndrome), Exposure to cold, Having emotional or physical stress, Having an infection, Fasting and not eating for a long period, Lack of sleep, Having periods, Not having enough water, Over exertion, Recovering from surgery, Skipping meals, Stress, Vigorous exercise.

• #49 Gilbert Syndrome – Causes, Symptoms, Diagnosis, and Treatment PACE Hospitals – Best Hospitals in Hitech City, Hyderabad, India | Near Madhapur, Kukatpally, KPHB, Kondapur, Gachibowli, Jubilee Hills, Banjara HillsPACE Hospitals Contact Num

  https://www.pacehospital.com/gilbert-syndrome-causes-symptoms-diagnosis-treatment

  Being dehydrated: Bilirubin levels increase following dehydration. […] Excessive alcohol consumption: Excessive consumption of alcohol increases bilirubin levels. […] Being ill due to an infection: Bilirubin levels increase following any illness […] Heavy physical exercise: Extreme physical activity and stress trigger hyperbilirubinemia […] Menstruation: Menstruation causes fluctuation in bilirubin levels […] Surgery: In patients who have undergone surgery, bilirubin levels may raise temporarily […] Inadequate sleep: Lack of sleep is considered a form of stress that can increase bilirubin production. […] It is a benign, autosomal recessive inherited disorder that affects the metabolism of bilirubin. Individuals with Gilbert syndrome are at increased risk for the following: […] Severe drug interactions […] Pigmented gallstones development […] Severe jaundice during neonatal age as well as in patients with coexisting hemolytic disease. […] There are no proven complications of Gilbert syndrome. It is not a risk for progressive liver disease or liver related mortality.

• #50 Gilbert’s Syndrome Serum, Plasma Samples – Bay Biosciences

  https://baybiosciences.com/gilberts-syndrome-serum-plasma-samples/

  Gilberts syndrome can cause the following signs and symptoms: Abdominal Pain and discomfort, Clay colored stool, Cold and flu like symptoms, Dark colored urine, Diarrhea, Difficulty concentrating, Dizziness, Fatigue, Jaundice Loss of appetite, Nausea. […] The signs and symptoms get more exacerbate in patients with Gilberts syndrome due to some of the following conditions, that can further increase the bilirubin levels, such as: Being sick, Drinking alcohol (Alcohol can raise bilirubin levels in patients with Gilberts syndrome), Exposure to cold, Having emotional or physical stress, Having an infection, Fasting and not eating for a long period, Lack of sleep, Having periods, Not having enough water, Over exertion, Recovering from surgery, Skipping meals, Stress, Vigorous exercise.

• #51 Gilbert’s Syndrome: Symptoms, Causes, Diagnosis, and Treatment

  https://www.healthline.com/health/gilberts-syndrome

  Some people with Gilberts syndrome also find that drinking alcohol makes their symptoms worse. For some people, even one or two drinks can make them feel sick shortly after. You might also have what feels like a hangover for several days. Alcohol can temporarily raise bilirubin levels in people with Gilberts syndrome. […] Most cases of Gilberts syndrome dont require treatment. However, if you start to have significant symptoms, including fatigue or nausea, your doctor might prescribe daily phenobarbital (Luminal) to help reduce the total amount of bilirubin in your body. […] Gilberts syndrome is a harmless condition that doesnt need to be treated. There is no change in life expectancy due to Gilberts syndrome. However, if you start to notice symptoms, you may need to make some lifestyle changes.

• #52 Gilbert Syndrome – Causes, Symptoms, Diagnosis, and Treatment PACE Hospitals – Best Hospitals in Hitech City, Hyderabad, India | Near Madhapur, Kukatpally, KPHB, Kondapur, Gachibowli, Jubilee Hills, Banjara HillsPACE Hospitals Contact Num

  https://www.pacehospital.com/gilbert-syndrome-causes-symptoms-diagnosis-treatment

  Being dehydrated: Bilirubin levels increase following dehydration. […] Excessive alcohol consumption: Excessive consumption of alcohol increases bilirubin levels. […] Being ill due to an infection: Bilirubin levels increase following any illness […] Heavy physical exercise: Extreme physical activity and stress trigger hyperbilirubinemia […] Menstruation: Menstruation causes fluctuation in bilirubin levels […] Surgery: In patients who have undergone surgery, bilirubin levels may raise temporarily […] Inadequate sleep: Lack of sleep is considered a form of stress that can increase bilirubin production. […] It is a benign, autosomal recessive inherited disorder that affects the metabolism of bilirubin. Individuals with Gilbert syndrome are at increased risk for the following: […] Severe drug interactions […] Pigmented gallstones development […] Severe jaundice during neonatal age as well as in patients with coexisting hemolytic disease. […] There are no proven complications of Gilbert syndrome. It is not a risk for progressive liver disease or liver related mortality.

• #53 Gilbert’s syndrome | The London Clinic

  https://www.thelondonclinic.co.uk/services/conditions/gilberts-syndrome

  Physical and emotional stress can trigger Gilberts syndrome symptoms or make them worse. […] If you have Gilberts syndrome you may find it harder to recover from stress. You may find symptoms of tiredness and yellowing of the skin become more noticeable. […] Most people dont know they have Gilberts syndrome unless they develop jaundice where their skin or eyes start to yellow. […] If the test results show you have high levels of bilirubin in your blood, but your liver is working well, it confirms a positive diagnosis of Gilberts syndrome. […] There is no cure for Gilberts syndrome as it is caused by a specific gene in DNA, and this makes it a lifelong condition. […] Jaundice and Gilberts syndrome do not damage the liver or cause complications so theres no specific treatment for it. […] Episodes of jaundice are usually short lived and dont increase the risk of other serious conditions.

• #54

  https://www.cbsnews.com/news/gilbert-syndrome-symptoms-treatment-bachelor-star-joey-graziadei/

  Symptoms can worsen under certain circumstances. For example, bilirubin levels may increase due to dehydration, getting sick, fasting or not eating enough, stress, or menstruation. […] „It’s worse when I have stress or lack of sleep, which happens on a TV show,” Graziadei says of his own experience. „It’s just something that I have to pay attention to in drinking more fluids.” […] „Gilbert’s syndrome is a mild condition. It doesn’t cause long-term complications or serious health problems,” the Cleveland Clinic notes.

• #55 Gilbert’s syndrome | The London Clinic

  https://www.thelondonclinic.co.uk/services/conditions/gilberts-syndrome

  Physical and emotional stress can trigger Gilberts syndrome symptoms or make them worse. […] If you have Gilberts syndrome you may find it harder to recover from stress. You may find symptoms of tiredness and yellowing of the skin become more noticeable. […] Most people dont know they have Gilberts syndrome unless they develop jaundice where their skin or eyes start to yellow. […] If the test results show you have high levels of bilirubin in your blood, but your liver is working well, it confirms a positive diagnosis of Gilberts syndrome. […] There is no cure for Gilberts syndrome as it is caused by a specific gene in DNA, and this makes it a lifelong condition. […] Jaundice and Gilberts syndrome do not damage the liver or cause complications so theres no specific treatment for it. […] Episodes of jaundice are usually short lived and dont increase the risk of other serious conditions.

• #56 Gilbert’s syndrome

  https://www.nhs.uk/conditions/gilberts-syndrome/

  Most people with Gilbert’s syndrome have occasional and short-lived episodes of yellowing of the skin and whites of the eyes (jaundice). It’s caused by the build-up of bilirubin in the blood. […] Around 1 in 3 people with Gilbert’s syndrome do not experience any symptoms at all. […] The jaundice of Gilbert’s syndrome is usually mild, but jaundice can be associated with more serious liver problems, such as cirrhosis or hepatitis C. […] Episodes of jaundice and any associated symptoms are usually short-lived and eventually pass.

• #57 Gilbert’s syndrome | nidirect

  https://www.nidirect.gov.uk/conditions/gilberts-syndrome

  Most people with Gilbert’s syndrome experience occasional and short-lived episodes of jaundice (yellowing of the skin and whites of the eyes) due to the build-up of bilirubin in the blood. […] As Gilbert’s syndrome usually only causes a slight increase in bilirubin levels, the yellowing of jaundice is often mild. The eyes are usually affected most. […] Some people also report other problems during episodes of jaundice, including: abdominal (tummy) pain, feeling very tired (fatigue), loss of appetite, feeling sick, dizziness, irritable bowel syndrome (IBS), problems concentrating and thinking clearly (brain fog), and a general sense of feeling unwell. […] Around one in three people with Gilberts syndrome don’t experience any symptoms at all. […] Episodes of jaundice and any associated symptoms are usually short-lived and eventually pass.

• #58 Gilbert disease Information | Mount Sinai – New York

  https://www.mountsinai.org/health-library/diseases-conditions/gilbert-disease

  Gilbert syndrome is a common disorder passed down through families. It affects the way bilirubin is processed by the liver, and may cause the skin to take on a yellow color (jaundice) at times. […] Symptoms may include: Fatigue, Yellowing of the skin and whites of the eyes (mild jaundice). In people with Gilbert syndrome, jaundice most often appears during times of exertion, stress, and infection, or when they do not eat. […] Jaundice may come and go throughout life. It is more likely to appear during illnesses such as colds. It does not cause health problems. However, it can confuse the results of tests for jaundice.

• #59 Gilbert’s syndrome | Better Health Channel

  https://www.betterhealth.vic.gov.au/health/conditionsandtreatments/gilberts-syndrome

  Gilberts syndrome is characterised by the livers inability to process the yellowish-brown pigment in bile (bilirubin). […] Too much bilirubin can cause yellowing of the skin and eyes (jaundice). […] Gilberts syndrome typically has no obvious symptoms, other than yellowing of the skin or eyes (jaundice). Other symptoms are sometimes reported, including: gastrointestinal complaints, fatigue, weakness, abdominal pain. […] However, it is not clear that these symptoms are directly related to higher levels of bilirubin. […] In a person with Gilberts syndrome, the bilirubin levels typically fluctuate and only sometimes hover within the normal range. […] Gilberts syndrome is a mild disorder that typically doesnt need medical treatment. People with the disorder lead normal, healthy lives. There is no evidence to suggest that the condition is harmful or leads to more serious diseases.

• #60 Gilbert’s syndrome | The London Clinic

  https://www.thelondonclinic.co.uk/services/conditions/gilberts-syndrome

  Gilberts syndrome is a common liver condition where having a specific gene means you cant get rid of a substance called bilirubin as well as you should. […] With Gilberts syndrome the bilirubin isnt properly excreted from your body and stays in your bloodstream which can cause your skin to turn slightly yellow. […] Its estimated around one in twenty people have Gilberts syndrome but many dont know it because symptoms can be very mild and difficult to diagnose. […] Although its present from birth, Gilberts syndrome isnt normally noticed until puberty. […] The symptoms of Gilberts syndrome can be mild and go unnoticed, but often it can come up as: Yellowing of the skin and whites of the eyes (jaundice), Tiredness (fatigue), Feeling sick (nausea), Vomiting, Upset stomach, Headaches, Anxiety, Insomnia.

• #61 Gilbert’s syndrome | Clear Chemist

  https://www.clearchemist.co.uk/az-health/gilbert-s-syndrome

  Most people with Gilbert’s syndrome will experience occasional and short-lived episodes of jaundice. This is when the skin and whites of the eyes turn slightly yellow. […] Some people also report other problems during episodes of jaundice, including: abdominal (tummy) pain, feeling very tired (fatigue), loss of appetite, feeling sick, dizziness, irritable bowel syndrome (IBS), problems concentrating and thinking clearly (brain fog), a general sense of feeling unwell. […] Around one in three people with Gilberts syndrome experience no noticeable symptoms, and you may not realise you have it until tests for an unrelated condition are carried out. […] Gilbert’s syndrome is more common in men than women and the symptoms usually first become apparent around puberty, possibly as a result of hormonal changes. […] Episodes of jaundice and any associated symptoms are only short-lived and will eventually pass.

• #62 Gilbert Syndrome (High Bilirubin): Causes, Symptoms, Treatment

  https://www.medicinenet.com/gilbert_syndrome/article.htm

  Gilbert syndrome is a harmless genetic condition that causes abnormal breakdown of bilirubin, a compound that is formed when hemoglobin from red blood cells degrades. High bilirubin can cause jaundice (yellowing of the eyes). Gilbert syndrome causes an abnormal breakdown of bilirubin. […] The elevated bilirubin pigment can sometimes cause mild yellowing (jaundice) of the eyes. People with Gilbert syndrome are otherwise entirely normal with no other signs or symptoms. Their liver enzyme levels in blood serum are also entirely normal. […] Gilbert syndrome is most commonly diagnosed after puberty when alterations in sex hormone levels cause the blood bilirubin levels to rise. Situations that aggravate elevated blood bilirubin levels (such as fasting, destruction of red blood cells, or illnesses) may be the initial factors that cause the patient to seek medical attention. […] There is no need for treatment, and the prognosis (outlook) is excellent.

• #63 Patient education: Gilbert syndrome (Beyond the Basics) – UpToDate

  https://www.uptodate.com/contents/gilbert-syndrome-beyond-the-basics/print

  Levels of bilirubin can fluctuate in people with Gilbert syndrome. They may be highest during an infection (such as the flu), following periods of fasting, and during menstrual periods in some women. In addition, newborns with Gilbert syndrome may have higher levels of bilirubin and more persistent jaundice than newborns without. […] Gilbert syndrome may also become apparent when an affected person takes certain drugs that require the enzyme involved in bilirubin processing in the liver. A cancer drug called irinotecan is one example.

• #64 Gilbert’s syndrome — Symptoms, causes and management | healthdirect

  https://www.healthdirect.gov.au/gilberts-syndrome

  Gilbert’s syndrome is a mild liver disorder. […] If bilirubin is not broken down, it can build up in your blood and can cause your eyes and skin to yellow (jaundice). […] Jaundice caused by Gilbert’s syndrome usually clears by itself without treatment. […] Most people with Gilbert’s syndrome do not have any symptoms. […] In some people, it causes yellowing of the eyes and skin (jaundice), due to higher levels of bilirubin in the blood. […] It’s normal for your bilirubin levels to vary over time. If you have Gilbert’s syndrome, they may go up or down when you are: sick or have an infection, fasting, during menstruation (your period). […] Newborns are sometimes born with jaundice. Babies with Gilbert’s syndrome may have higher levels of bilirubin and take longer to recover from jaundice.

• #65 Gilbert Syndrome: Symptoms & Complications

  https://liverfoundation.org/liver-diseases/rare-disease/gilbert-syndrome/

  Gilbert Syndrome is a mild genetic disorder in which the liver does not properly process a substance called bilirubin. Bilirubin is made by the break down of red blood cells. […] Gilbert Syndrome affects three to seven percent of people in the United States. Gilbert Syndrome is more common in men than women. […] Individuals with Gilbert Syndrome have elevated levels of bilirubin (hyperbilirubinemia), because they have a reduced level of a specific liver enzyme required for elimination of bilirubin. […] People with Gilbert Syndrome usually do not have symptoms. Gilbert Syndrome sometimes causes the liver to make too much bilirubin that the person becomes jaundiced (yellowing of eyes and skin). […] Certain things can further increase the level of bilirubin in the bodies of those with Gilbert Syndrome: Being ill, Menstruating, Fasting or skipping meals, Exercising too much. […] Complications of Gilbert Syndrome may include certain medications causing side effects in people who have Gilbert Syndrome. Talk to a doctor before taking any new medications. […] Since Gilbert Syndrome is a mild and manageable condition, it does not need treatment.

• #66

  https://www.nuhs.edu.sg/patient-care/find-a-condition/gilberts-syndrome

  Gilbert’s Syndrome is an inherited disorder of the liver that results in an excess of bilirubin. […] People with Gilbert’s Syndrome have an inherited abnormality that causes reduced production of an enzyme involved in processing bilirubin. As a result, a form of bilirubin (known as unconjugated bilirubin) accumulates in the blood, sometimes causing the yellowing of the skin or eyes. […] Most patients with Gilbert’s Syndrome have no symptoms. The disorder is frequently diagnosed by coincidence when a lab test done for another reason such as a life insurance examination, shows an abnormally high amount of unconjugated bilirubin. […] The level of bilirubin can fluctuate in people with Gilbert’s Syndrome. They may be highest after an infection (such as flu), following periods of fasting, and after menstrual periods in some women. […] Because males tend to produce higher levels of bilirubin, the disorder is more likely to be detected in men. Similarly, it is rarely diagnosed before puberty because production of bilirubin increases at this point.

• #67 Gilbert Syndrome – StatPearls – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK470200/

  Gilbert syndrome is a common genetic disorder affecting bilirubin metabolism in the liver. This autosomal recessive condition leads to mild to moderate unconjugated hyperbilirubinemia, often presenting as recurrent episodes of jaundice. […] The prognosis for individuals with Gilbert syndrome is excellent, and the condition does not lead to significant liver disease. However, patients with Gilbert syndrome may have an increased risk of drug toxicity when exposed to medications that affect bilirubin metabolism. […] Patients with Gilbert syndrome typically have normal liver function tests aside from elevated unconjugated bilirubin levels. The condition is generally asymptomatic and does not require treatment, but several factors, including fasting, illness, menstruation, and dehydration, may trigger symptoms.

• #68 Gilbert Syndrome – StatPearls – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK470200/

  The prognosis of patients with Gilbert syndrome is excellent. […] Patients with Gilbert syndrome do not require treatment. Therefore, management primarily consists of reassuring patients and their families that this is a benign condition that does not require further testing. […] Gilbert syndrome is a benign, autosomal recessive inherited disorder of bilirubin metabolism. […] Patients are at an increased risk for more severe drug interactions, the development of pigmented gallstones, and more severe jaundice during the neonatal age, as well as in individuals with coexisting hemolytic diseases. […] Patients with this disease are not at risk for progressive liver disease, hepatic decompensation, or liver-related mortality. […] Patients and their families should be informed of the disease’s inherited and benign nature, and unnecessary testing should be avoided.

• #69 Gilbert’s Syndrome: Symptoms, Causes, Tests & Treatment

  https://my.clevelandclinic.org/health/diseases/17661-gilberts-syndrome

  Gilbert’s syndrome is a mild condition. It doesnt cause long-term complications or serious health problems. […] People with Gilbert’s syndrome can lead long, healthy lives. They dont experience long-term health problems from the disease. […] Gilbert’s syndrome is a mild disorder that doesnt require treatment. While occasional yellowish eyes and skin may be unsettling, jaundice doesnt pose any health risks. This skin and eye coloration will go away on its own. Your healthcare provider can suggest ways to reduce episodes of jaundice associated with Gilbert’s syndrome.

• #70 Gilbert’s syndrome | Better Health Channel

  https://www.betterhealth.vic.gov.au/health/conditionsandtreatments/gilberts-syndrome

  Gilberts syndrome is characterised by the livers inability to process the yellowish-brown pigment in bile (bilirubin). […] Too much bilirubin can cause yellowing of the skin and eyes (jaundice). […] Gilberts syndrome typically has no obvious symptoms, other than yellowing of the skin or eyes (jaundice). Other symptoms are sometimes reported, including: gastrointestinal complaints, fatigue, weakness, abdominal pain. […] However, it is not clear that these symptoms are directly related to higher levels of bilirubin. […] In a person with Gilberts syndrome, the bilirubin levels typically fluctuate and only sometimes hover within the normal range. […] Gilberts syndrome is a mild disorder that typically doesnt need medical treatment. People with the disorder lead normal, healthy lives. There is no evidence to suggest that the condition is harmful or leads to more serious diseases.

• #71 The frequency, clinical course, and health related quality of life in adults with Gilbert’s syndrome: a longitudinal study | BMC Gastroenterology | Full Text

  https://bmcgastroenterol.biomedcentral.com/articles/10.1186/s12876-019-0931-2

  Gilbert syndrome (GS) is an autosomal recessive inherited disorder of bilirubin glucuronidation which has not been investigated in Egypt. This longitudinal study investigated the frequency, clinical course, genetic profile and health related quality of life in Egyptian adults. […] Recurrent jaundice was the only presentation in 47 (56.627%) GS subjects and jaundice was associated with abdominal pain, dyspepsia or loss of appetite in 54 (53.465%) subjects. […] In a substantial percentage of subjects with GS, episodes of jaundice are associated with other symptoms and nutritional deficiencies which result in impairment of HRQOL. […] During jaundice attacks, subjects with GS had significant differences in vitality, role emotional, social functioning, worry and general health domains of the SF-36v2 and CLDQ compared to controls.

• #72 The frequency, clinical course, and health related quality of life in adults with Gilbert’s syndrome: a longitudinal study | BMC Gastroenterology | Full Text

  https://bmcgastroenterol.biomedcentral.com/articles/10.1186/s12876-019-0931-2

  The study showed that women were exposed to additional risk factors for hyperbilirubinemia particularly menstrual abnormalities, pregnancy and deliveries. […] The current study showed that the quality of life in GS subjects is affected particularly during the jaundice episodes. Subjects with GS had significant differences in SF-6D preference, vitality, role emotional, social functioning, worry and general health.

• #73 Gilbert Syndrome – StatPearls – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK470200/

  The prognosis of patients with Gilbert syndrome is excellent. […] Patients with Gilbert syndrome do not require treatment. Therefore, management primarily consists of reassuring patients and their families that this is a benign condition that does not require further testing. […] Gilbert syndrome is a benign, autosomal recessive inherited disorder of bilirubin metabolism. […] Patients are at an increased risk for more severe drug interactions, the development of pigmented gallstones, and more severe jaundice during the neonatal age, as well as in individuals with coexisting hemolytic diseases. […] Patients with this disease are not at risk for progressive liver disease, hepatic decompensation, or liver-related mortality. […] Patients and their families should be informed of the disease’s inherited and benign nature, and unnecessary testing should be avoided.

• #74 Gilbert Syndrome – Causes, Symptoms, Diagnosis, and Treatment PACE Hospitals – Best Hospitals in Hitech City, Hyderabad, India | Near Madhapur, Kukatpally, KPHB, Kondapur, Gachibowli, Jubilee Hills, Banjara HillsPACE Hospitals Contact Num

  https://www.pacehospital.com/gilbert-syndrome-causes-symptoms-diagnosis-treatment

  Being dehydrated: Bilirubin levels increase following dehydration. […] Excessive alcohol consumption: Excessive consumption of alcohol increases bilirubin levels. […] Being ill due to an infection: Bilirubin levels increase following any illness […] Heavy physical exercise: Extreme physical activity and stress trigger hyperbilirubinemia […] Menstruation: Menstruation causes fluctuation in bilirubin levels […] Surgery: In patients who have undergone surgery, bilirubin levels may raise temporarily […] Inadequate sleep: Lack of sleep is considered a form of stress that can increase bilirubin production. […] It is a benign, autosomal recessive inherited disorder that affects the metabolism of bilirubin. Individuals with Gilbert syndrome are at increased risk for the following: […] Severe drug interactions […] Pigmented gallstones development […] Severe jaundice during neonatal age as well as in patients with coexisting hemolytic disease. […] There are no proven complications of Gilbert syndrome. It is not a risk for progressive liver disease or liver related mortality.

• #75 Patient education: Gilbert syndrome (Beyond the Basics) – UpToDate

  https://www.uptodate.com/contents/gilbert-syndrome-beyond-the-basics/print

  Levels of bilirubin can fluctuate in people with Gilbert syndrome. They may be highest during an infection (such as the flu), following periods of fasting, and during menstrual periods in some women. In addition, newborns with Gilbert syndrome may have higher levels of bilirubin and more persistent jaundice than newborns without. […] Gilbert syndrome may also become apparent when an affected person takes certain drugs that require the enzyme involved in bilirubin processing in the liver. A cancer drug called irinotecan is one example.

• #76 Gilbert’s syndrome history and symptoms – wikidoc

  https://www.wikidoc.org/index.php/Gilbert%27s_syndrome_history_and_symptoms

  Jaundice: Gilbert’s syndrome produces an elevated level of unconjugated bilirubin in the bloodstream but normally this has no serious consequence. Mild jaundice may appear under conditions of exertion, stress, fasting, and infections, but the condition is otherwise usually asymptomatic. […] Some patients report experiencing unpleasant physical symptoms during episodes of high bilirubin levels. They may report meal-related fatigue, tremors, nausea, and abdominal pain, with jaundice. […] Detoxification of certain drugs: The enzymes that are defective in GS (UGT1A1) are also responsible for some of the liver’s ability to detoxify certain drugs. For example, Gilbert’s syndrome is associated with severe diarrhea and neutropenia in patients who are treated with irinotecan, which is metabolized by UGT1A1.

• #77 Gilbert Syndrome – StatPearls – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK470200/

  The prognosis of patients with Gilbert syndrome is excellent. […] Patients with Gilbert syndrome do not require treatment. Therefore, management primarily consists of reassuring patients and their families that this is a benign condition that does not require further testing. […] Gilbert syndrome is a benign, autosomal recessive inherited disorder of bilirubin metabolism. […] Patients are at an increased risk for more severe drug interactions, the development of pigmented gallstones, and more severe jaundice during the neonatal age, as well as in individuals with coexisting hemolytic diseases. […] Patients with this disease are not at risk for progressive liver disease, hepatic decompensation, or liver-related mortality. […] Patients and their families should be informed of the disease’s inherited and benign nature, and unnecessary testing should be avoided.

• #78 Gilbert’s Disease: Causes, Symptoms, Diagnosis, and Treatment • Yesil Health

  https://yesilhealth.com/your-health/gilberts-disease-causes-symptoms-diagnosis-and-treatment/

  Its essential to note that these symptoms can be mild and may not always be present. In some cases, people with Gilberts disease may not experience any symptoms at all. […] Jaundice is often the most noticeable symptom of Gilberts disease. Other symptoms may include: Fatigue, Abdominal pain, Nausea and vomiting, Dark urine, Pale stools. […] While Gilberts disease is generally a mild condition, it can lead to complications if left unmanaged or if underlying liver function is severely impaired. […] Chronic liver damage can occur if Gilberts disease is left untreated or if underlying liver function is severely impaired. This can lead to: Liver cirrhosis: Scarring of the liver tissue, which can lead to liver failure. Liver cancer: Increased risk of developing liver cancer, particularly if underlying liver function is severely impaired.

• #79 Gilbert Syndrome – StatPearls – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK470200/

  The prognosis of patients with Gilbert syndrome is excellent. […] Patients with Gilbert syndrome do not require treatment. Therefore, management primarily consists of reassuring patients and their families that this is a benign condition that does not require further testing. […] Gilbert syndrome is a benign, autosomal recessive inherited disorder of bilirubin metabolism. […] Patients are at an increased risk for more severe drug interactions, the development of pigmented gallstones, and more severe jaundice during the neonatal age, as well as in individuals with coexisting hemolytic diseases. […] Patients with this disease are not at risk for progressive liver disease, hepatic decompensation, or liver-related mortality. […] Patients and their families should be informed of the disease’s inherited and benign nature, and unnecessary testing should be avoided.

• #80 Gilbert’s syndrome — Symptoms, causes and management | healthdirect

  https://www.healthdirect.gov.au/gilberts-syndrome

  Gilbert’s syndrome is a mild liver disorder. […] If bilirubin is not broken down, it can build up in your blood and can cause your eyes and skin to yellow (jaundice). […] Jaundice caused by Gilbert’s syndrome usually clears by itself without treatment. […] Most people with Gilbert’s syndrome do not have any symptoms. […] In some people, it causes yellowing of the eyes and skin (jaundice), due to higher levels of bilirubin in the blood. […] It’s normal for your bilirubin levels to vary over time. If you have Gilbert’s syndrome, they may go up or down when you are: sick or have an infection, fasting, during menstruation (your period). […] Newborns are sometimes born with jaundice. Babies with Gilbert’s syndrome may have higher levels of bilirubin and take longer to recover from jaundice.

• #81 Gilbert’s Syndrome: Symptoms, Causes, Diagnosis, and Treatment

  https://www.healthline.com/health/gilberts-syndrome

  Some people with Gilberts syndrome also find that drinking alcohol makes their symptoms worse. For some people, even one or two drinks can make them feel sick shortly after. You might also have what feels like a hangover for several days. Alcohol can temporarily raise bilirubin levels in people with Gilberts syndrome. […] Most cases of Gilberts syndrome dont require treatment. However, if you start to have significant symptoms, including fatigue or nausea, your doctor might prescribe daily phenobarbital (Luminal) to help reduce the total amount of bilirubin in your body. […] Gilberts syndrome is a harmless condition that doesnt need to be treated. There is no change in life expectancy due to Gilberts syndrome. However, if you start to notice symptoms, you may need to make some lifestyle changes.

• #82 Gilbert’s Syndrome – Reduce Symptoms & Support Liver Health

  https://advancedfunctionalmedicine.com.au/gilbert-syndrome/

  If you do have Gilbert syndrome, you may find certain things make an episode of jaundice more likely. Some of these triggers include the following: dieting or not eating for a long time, not drinking enough (being dehydrated can trigger Gilbert syndrome), being under a lot of stress, anxiety, exerting yourself physically, not getting enough sleep, having an infection, having surgery, having your period, drinking alcohol, taking certain medicines (these include some cancer treatments, a cholesterol medicine called gemfibrozil and some antiretroviral drugs used to treat HIV), illness such as influenza, taking large amounts of Vitamin B3 (niacin). […] As Gilbert syndrome is generally harmless, conventional medicine does not usually treat the condition. It will not damage the liver and apart from jaundice, there are no known complications.

• #83 Gilbert’s Syndrome: Symptoms, Causes, Tests & Treatment

  https://my.clevelandclinic.org/health/diseases/17661-gilberts-syndrome

  People with Gilbert’s syndrome inherit a mutated gene that affects the livers ability to process bilirubin, a waste product that forms during the breakdown of old red blood cells. Jaundice (yellowish skin and eyes) occurs when too much bilirubin builds up in blood. Because this liver disease doesnt cause serious problems, treatment isnt necessary. […] Approximately 1 in 3 people with Gilbert’s syndrome dont have symptoms. They learn that they have the disease after getting blood tests to check for a different problem. […] Among those with symptoms, the most common sign is jaundice, brought on by elevated levels of bilirubin in blood. Jaundice can turn your skin and whites of the eyes yellow, but it isnt harmful. […] Occasionally, people who have jaundice or Gilbert’s syndrome also experience: Dark-colored urine or clay-colored stool. Difficulty concentrating. Dizziness. Gastrointestinal problems, such as abdominal pain, diarrhea and nausea. Fatigue. Flu-like symptoms, including fever and chills. Loss of appetite.

• #84 Gilbert syndrome – Diagnosis & treatment – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/gilberts-syndrome/diagnosis-treatment/drc-20372816

  Your health care provider may suspect Gilbert syndrome if you have unexplained jaundice or if the level of bilirubin is elevated in your blood. Other symptoms that suggest Gilbert syndrome as well as a number of other liver conditions include dark urine and abdominal pain. […] Gilbert syndrome doesn’t require treatment. The bilirubin levels in your blood may fluctuate over time. You may occasionally have jaundice, which usually resolves on its on with no ill effects. […] Certain life events, such as stress, can trigger episodes of higher bilirubin levels in Gilbert syndrome, leading to jaundice. Taking steps to manage those situations can help keep bilirubin levels under control.

• #85 Gilbert’s syndrome — Symptoms, causes and management | healthdirect

  https://www.healthdirect.gov.au/gilberts-syndrome

  There is no need to treat Gilbert’s syndrome, as most people with Gilbert’s syndrome do not have any symptoms. […] Jaundice caused by Gilbert’s syndrome will usually resolve by itself without treatment. […] You should seek medical attention if you have Gilbert’s syndrome and: your jaundice doesn’t resolve on its own, the jaundice is severe, you have changes to the colour of your stool (poo) or urine (wee).

• #86 Gilbert’s syndrome

  https://www.nhs.uk/conditions/gilberts-syndrome/

  Most people with Gilbert’s syndrome have occasional and short-lived episodes of yellowing of the skin and whites of the eyes (jaundice). It’s caused by the build-up of bilirubin in the blood. […] Around 1 in 3 people with Gilbert’s syndrome do not experience any symptoms at all. […] The jaundice of Gilbert’s syndrome is usually mild, but jaundice can be associated with more serious liver problems, such as cirrhosis or hepatitis C. […] Episodes of jaundice and any associated symptoms are usually short-lived and eventually pass.

• #87 Gilbert’s syndrome | Better Health Channel

  https://www.betterhealth.vic.gov.au/health/conditionsandtreatments/gilberts-syndrome

  Gilberts syndrome is characterised by the livers inability to process the yellowish-brown pigment in bile (bilirubin). […] Too much bilirubin can cause yellowing of the skin and eyes (jaundice). […] Gilberts syndrome typically has no obvious symptoms, other than yellowing of the skin or eyes (jaundice). Other symptoms are sometimes reported, including: gastrointestinal complaints, fatigue, weakness, abdominal pain. […] However, it is not clear that these symptoms are directly related to higher levels of bilirubin. […] In a person with Gilberts syndrome, the bilirubin levels typically fluctuate and only sometimes hover within the normal range. […] Gilberts syndrome is a mild disorder that typically doesnt need medical treatment. People with the disorder lead normal, healthy lives. There is no evidence to suggest that the condition is harmful or leads to more serious diseases.

• #88 Gilbert syndrome: Symptoms, diet, and treatment

  https://www.medicalnewstoday.com/articles/166971

  Mild jaundice is the only sign that a person has Gilbert syndrome. […] Many people with Gilbert syndrome have no symptoms. Around 30 percent find out they have it by chance through routine tests. […] If a person has too much bilirubin, they will have jaundice, a yellow tinge to the whites of the eyes. The skin, too, can take on a yellowish tinge, if levels rise further. […] A person with Gilberts syndrome is unlikely to have specific symptoms, beyond some yellowing of the eyes. […] Some people may experience fatigue and abdominal discomfort, but experts have made no connection between higher bilirubin levels and these symptoms. […] Bilirubin levels do not reach very high levels with Gilberts syndrome, but the jaundice can be disturbing.

• #89 Gilbert’s Syndrome: Symptoms, Causes, Tests & Treatment

  https://my.clevelandclinic.org/health/diseases/17661-gilberts-syndrome

  Gilbert’s syndrome is a mild condition. It doesnt cause long-term complications or serious health problems. […] People with Gilbert’s syndrome can lead long, healthy lives. They dont experience long-term health problems from the disease. […] Gilbert’s syndrome is a mild disorder that doesnt require treatment. While occasional yellowish eyes and skin may be unsettling, jaundice doesnt pose any health risks. This skin and eye coloration will go away on its own. Your healthcare provider can suggest ways to reduce episodes of jaundice associated with Gilbert’s syndrome.

• #90 Gilbert Syndrome – StatPearls – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK470200/

  The prognosis of patients with Gilbert syndrome is excellent. […] Patients with Gilbert syndrome do not require treatment. Therefore, management primarily consists of reassuring patients and their families that this is a benign condition that does not require further testing. […] Gilbert syndrome is a benign, autosomal recessive inherited disorder of bilirubin metabolism. […] Patients are at an increased risk for more severe drug interactions, the development of pigmented gallstones, and more severe jaundice during the neonatal age, as well as in individuals with coexisting hemolytic diseases. […] Patients with this disease are not at risk for progressive liver disease, hepatic decompensation, or liver-related mortality. […] Patients and their families should be informed of the disease’s inherited and benign nature, and unnecessary testing should be avoided.

• #91 Gilbert Syndrome: Symptoms & Complications

  https://liverfoundation.org/liver-diseases/rare-disease/gilbert-syndrome/

  Gilbert Syndrome is a mild genetic disorder in which the liver does not properly process a substance called bilirubin. Bilirubin is made by the break down of red blood cells. […] Gilbert Syndrome affects three to seven percent of people in the United States. Gilbert Syndrome is more common in men than women. […] Individuals with Gilbert Syndrome have elevated levels of bilirubin (hyperbilirubinemia), because they have a reduced level of a specific liver enzyme required for elimination of bilirubin. […] People with Gilbert Syndrome usually do not have symptoms. Gilbert Syndrome sometimes causes the liver to make too much bilirubin that the person becomes jaundiced (yellowing of eyes and skin). […] Certain things can further increase the level of bilirubin in the bodies of those with Gilbert Syndrome: Being ill, Menstruating, Fasting or skipping meals, Exercising too much. […] Complications of Gilbert Syndrome may include certain medications causing side effects in people who have Gilbert Syndrome. Talk to a doctor before taking any new medications. […] Since Gilbert Syndrome is a mild and manageable condition, it does not need treatment.

• #92 Gilbert’s Syndrome + 10 Natural Ways to Boost Liver Health – Dr. Axe

  https://draxe.com/health/gilberts-syndrome/

  It is important, however, if youve received a Gilberts syndrome diagnosis that you inform all of your doctors as it can affect the way your body processes and releases certain medications, including cancer therapy drugs. Additionally, Gilberts syndrome and alcohol intolerance are a concern. If you drink to excess with Gilberts syndrome, you may experience an exceptionally severe hangover. […] Jaundice, a yellowing of the skin or the whites of your eyes, may be the only Gilberts syndrome symptom you experience. […] Diagnosis may not occur until you present with jaundice or have a routine blood test that indicates elevated levels of bilirubin. […] It generally does not require treatment; however, it is important to inform your doctors as Gilberts syndrome may cause your body to improperly process some medications.

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