Materiały źródłowe

• #1 Cerebral Aneurysm – StatPearls – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK507902/

  Cerebral aneurysms are defined as dilations that occur at weak points along the arterial circulation within the brain. The majority of cerebral aneurysms are silent and may be found incidentally on neuroimaging or upon autopsy. Approximately 85% of aneurysms are located in the anterior circulation, predominately at junctions or bifurcations along the circle of Willis. Subarachnoid hemorrhage (SAH) usually occurs with rupture and is associated with a high rate of morbidity and mortality. […] The worldwide prevalence of cerebral aneurysms is approximately 3.2%, with a mean age of 50 and an overall 1:1 gender ratio. This ratio changes significantly after age 50, with an increasing female predominance approaching 2:1, thought to be due to decreased circulating estrogen causing a reduction in the collagen content of the vascular tissue. The rate of rupture causing SAH is about 10 per 100,000. This is higher in certain populations such as the Finnish and Japanese. However, this is not due to a higher prevalence of aneurysms in these populations. The overall mortality due to aneurysmal SAH is considered to be 0.4 to 0.6% of all-cause deaths, with an approximate 20% mortality and an additional 30 to 40% morbidity in patients with known rupture.

• #2 Brain aneurysms: Prevalence and more

  https://www.medicalnewstoday.com/articles/how-common-are-brain-aneurysms

  Unruptured aneurysms affect about 3.2% of people worldwide. Ruptured aneurysms are less common, occurring in approximately 10 per 100,000 cases. […] In the United States, about 6.7 million individuals have the unruptured type, and rupture happens in an estimated 30,000 annually. Hispanic and African American people have twice the risk. […] Worldwide, the condition causes 500,000 deaths annually half of which are people younger than 50 years. […] In the U.S., about 6.7 million people have an unruptured brain aneurysm, and about 30,000 per year have the ruptured type. […] Various factors such as genetics, smoking, and untreated high blood pressure can increase a persons risk of the condition.

• #3 Epidemiology, risk factors, pathogenesis, and natural history of abdominal aortic aneurysm – UpToDate

  https://www.uptodate.com/contents/epidemiology-risk-factors-pathogenesis-and-natural-history-of-abdominal-aortic-aneurysm

  Epidemiology, risk factors, pathogenesis, and natural history of abdominal aortic aneurysm […] The epidemiology, risk factors, pathogenesis, and natural history of AAA are reviewed here. […] The prevalence of abdominal aortic aneurysm (AAA) is 3 to 8 percent in screening studies, affecting predominantly males. […] The annual incidence of new AAA diagnoses is approximately 0.4 to 0.67 percent in Western populations. […] Age significantly impacts the incidence. […] The incidence of AAA discovery may be decreasing, however. […] Natural history of AAA under surveillance.

• #4 Time-of-Flight MRA of Intracranial Aneurysms with Interval Surveillance, Clinical Segmentation and Annotations | Scientific Data

  https://www.nature.com/articles/s41597-024-03397-8

  Intracranial aneurysms (IAs) are present in 26% of the global population and can be catastrophic upon rupture with a mortality rate of 3050%. IAs are commonly detected through time-of-flight magnetic resonance angiography (TOF-MRA), however, this data is rarely available for research and training purposes. […] To support efforts in addressing data availability bottlenecks, we provide an open-access TOF-MRA dataset comprising 63 patients, of which 24 underwent interval surveillance imaging by TOF-MRA. […] This dataset is the first to provide interval surveillance imaging for supporting the understanding of IA growth and stability. […] Importantly, this work differs to the existing databases by providing interval surveillance imaging on 24 subjects, ranging from 112 years of surveillance. This data is useful for investigating changes in size and morphology of IAs over time, which may help validate the predictive risk of IA geometry and fluid dynamics in rupture.

• #5 Statistics and Facts – Brain Aneurysm Foundation

  https://www.bafound.org/statistics-and-facts/

  An estimated 6.8 million people in the United States have an unruptured brain aneurysm, or 1 in 50 people. […] The annual rate of rupture is approximately 8 – 10 per 100,000 people. […] About 30,000 people in the United States suffer a brain aneurysm rupture each year. A brain aneurysm ruptures every 18 minutes. […] There are almost 500,000 deaths worldwide each year caused by brain aneurysms, and half the victims are younger than 50. […] Brain aneurysms are most prevalent in people ages 35 to 60, but can occur in children as well. Most aneurysms develop after the age of 40. […] Women are more likely than men to have a brain aneurysm (3:2 ratio). […] Women, particularly those over the age of 55, have a higher risk of brain aneurysm rupture than men (about 1.5 times the risk). […] African-Americans and Hispanics are about twice as likely to have a brain aneurysm rupture compared to caucasians.

• #6 Intracranial aneurysm – Wikipedia

  https://en.wikipedia.org/wiki/Intracranial_aneurysm

  The prevalence of intracranial aneurysm is about 15% (10 million to 12 million persons in the United States) and the incidence is 1 per 10,000 persons per year in the United States (approximately 27,000), with 30- to 60-year-olds being the age group most affected. […] Intracranial aneurysms occur more in women, by a ratio of 3 to 2, and are rarely seen in pediatric populations.

• #7 < ?php wp_title( '|', true, 'right' ); ?>

  https://surgicalneurologyint.com/surgicalint-articles/epidemiological-analysis-of-1404-patients-with-intracranial-aneurysm-followed-in-a-single-brazilian-institution/

  Conclusion: In this population, the occurrence of intracranial aneurysm is related to several factors, including gender, age, smoking, and hypertension. Our study brought to light important characteristics of a large number of Brazilian patients regarding epidemiology, location, size, and multiplicity of intracranial aneurysms. […] INTRODUCTION […] Intracranial aneurysms are the leading cause of spontaneous subarachnoid hemorrhage (SAH) accounting for up to 85% of cases. It is estimated that half a million people every year suffer from aneurysmal SAH. The mortality rate in SAH is 25-50% and half of the survivors become dependent on activities of daily living. Several risk factors appear to be associated with the development of intracranial aneurysms, including age, female gender, genetic factors, smoking, and hypertension.

• #8 Intracranial Aneurysms: Current Evidence and Clinical Practice | AAFP

  https://www.aafp.org/pubs/afp/issues/2002/0815/p601.html

  Unruptured intracranial aneurysms occur in up to 6 percent of the general population. […] A recent systematic review of studies involving more than 56,000 patients found that unruptured intracranial aneurysms occur in 3.6 to 6 percent of the general population. […] The incidence of intracranial aneurysms is between 8 and 9 percent in persons with two or more relatives who have had a subarachnoid hemorrhage or an aneurysm. […] Recent data have shown that age over 50 years, female gender, and current cigarette smoking are risk factors for intracranial aneurysm. […] Since 1984, cocaine use has been linked to the formation and rupture of aneurysms. […] The findings of the International Study of Unruptured Intracranial Aneurysms (ISUIA) were published in 1998. […] The ISUIA data suggest that aneurysms with a diameter of 10 mm or more are at critical risk for rupture.

• #9 Cerebral Aneurysm: Practice Essentials, Background, Pathophysiology

  https://emedicine.medscape.com/article/1161518-overview

  The frequency of cerebral aneurysms is difficult to ascertain because of variation in the definitions of the size of aneurysm and modes of detection. Autopsy series cite a prevalence range of 1%5%. Prevalence ranges from 5-10%, with unruptured aneurysms accounting for 50% of all aneurysms. Pediatric aneurysms account for only 2% of all cerebral aneurysms. In the United States, the incidence of ruptured aneurysms is approximately 12 per 100,000 individuals or 30,000 annual cases of aneurysmal SAH. The frequency of cerebral aneurysms has not declined in recent years. […] Incidence of aneurysmal SAH varies widely depending on geographic location, with Finland and Japan having the highest reported rates. Overall, the incidence has been estimated at 10.5 per 100,000 individuals. […] The racial predilection of cerebral aneurysms is largely unknown, although a higher incidence has been noted in African Americans, with an odds ratio of 2:1. Cerebral aneurysms affect equal numbers of women and men younger than 40 years, although women are affected more frequently in older age groups. Overall, the female-to-male ratio has been estimated at 1.6:1. Saccular aneurysms are most common in the anterior communicating artery (ACoA) or anterior cerebral artery (ACA) in men, whereas the junction of the ICA with the posterior communicating artery (PCoA) is the most common site for saccular aneurysms in women. Giant aneurysms are three times more common in women than men. The prognosis of aneurysmal SAH is worse for women than men. […] Cerebral aneurysms are rarely apparent in infants and children. Clinical manifestations increase with age, reaching a peak in people aged 5560 years. Carotid artery is affected most commonly in individuals younger than 18 years. The prognosis of aneurysmal SAH worsens with increasing age.

• #10 < ?php wp_title( '|', true, 'right' ); ?>

  https://surgicalneurologyint.com/surgicalint-articles/epidemiological-analysis-of-1404-patients-with-intracranial-aneurysm-followed-in-a-single-brazilian-institution/

  In our study, we found a higher rate of female patients with cerebral aneurysms (77.6%). This trending was also true in other studies performed worldwide. When analyzing studies that stratify the gender percentage in a series of patients with intracranial aneurysms, the female rates were 54% in Finnish studies, 62% in a Chinese study, 68% in a Japanese study, and about 72% for the populations of North America and Europe. Therefore, even though our data are consistent with those studies, it seems that the Brazilian percentage of female patients with cerebral aneurysm is much higher than in other countries. […] The mean age of the patients studied was 54.9 years, consistent with other studies that show an average age of 50 years for the world population diagnosed with intracranial aneurysm. Another interesting finding was that the average age of female was greater than that of male (55.6 and 52.4 years, respectively). This finding may result from the hypothesized protective vascular effects of estrogen until menopause.

• #11 Epidemiology of abdominal aortic aneurysms – PubMed

  https://pubmed.ncbi.nlm.nih.gov/33757632/

  Abdominal aortic aneurysm (AAA) disease remains a major source of morbidity in developed countries and can progress to life-threatening rupture if left untreated, with exceedingly high mortality. The goal of AAA management is to identify and electively repair AAAs before rupture. AAA disease burden and outcomes have improved over time with declining tobacco use and advancements in care across patients’ disease course. […] However, these improved outcomes are not universally experienced, and disparities continue to exist in the detection, treatment, and outcomes of AAA by sex, race, and ethnicity. Mitigating these disparities requires enhanced, focused efforts at preventing disease, promoting health, and delivering appropriate care among an increasingly diverse patient population.

• #12 Abdominal aortic aneurysm surveillance program saving lives

  https://health.ucdavis.edu/news/headlines/abdominal-aortic-aneurysm-surveillance-program-saving-lives/2022/11

  UC Davis Health and AI (artificial intelligence) software company Illuminate have developed a centralized abdominal aortic aneurysm surveillance program that is saving lives. […] The goal is to identify existing patients in the UC Davis electronic health record who may have an abdominal aortic aneurysm and who need follow-up care. […] The goal of this program is to support primary care physicians to manage our AAA patients with small aneurysms before they become a problem, and streamline the process of vascular surgery referrals, said Mell. […] According to the Society for Vascular Surgery, each year 200,000 people in the United States are diagnosed with an AAA. A ruptured AAA is the 15th leading cause of death in the country and the 10th leading cause of death in men older than 55.

• #13 Abdominal Aortic Aneurysms: Surveillance & Early Repair

  https://www.illuminate.ai/disease-pages/abdominal-aortic-aneurysms

  Patients whose abdominal aortic aneurysms are repaired prior to rupture have at least a 90% survival rate. But too many identified aneurysms go untreated […] Patients whose aneurysms are repaired prior to rupture have at least a 90% survival rate. The survival rate drops to 20% at rupture. […] Illuminate Discovery360 AAA analyzed our entire EMR allowing us to identify and contact at-risk patients who had no idea they needed additional care.

• #14 Abdominal Aortic Aneurysm Market Predicted to See Upsurge

  https://www.openpr.com/news/4004363/abdominal-aortic-aneurysm-market-predicted-to-see-upsurge

  DelveInsight’s „Abdominal Aortic Aneurysm Market Insights, Epidemiology, and Market Forecast-2034 report offers an in-depth understanding of the Abdominal Aortic Aneurysm, historical and forecasted epidemiology as well as the Abdominal Aortic Aneurysm market trends in the United States, EU4 (Germany, Spain, Italy, France) the United Kingdom and Japan. […] The total diagnosed prevalence of Abdominal Aortic Aneurysm in the 7MM was estimated at 1,641,380 cases in 2021, with expectations for an increase over the study period from 2020 to 2034. […] The Abdominal Aortic Aneurysm epidemiology based on gender analyzed that Abdominal aortic aneurysms are more common in men. […] The Abdominal Aortic Aneurysm market is expected to surge due to the disease’s increasing prevalence and awareness during the forecast period.

• #15

  https://link.springer.com/article/10.1007/s44197-025-00369-y

  Aortic aneurysm has a subtle onset, high rupture mortality, rapid progression in younger individuals, and increasing annual mortality rates. Our study aimed to estimate the global burden and trends of early-onset aortic aneurysm from 1990 to 2021. […] From 1990 to 2021, the ASDR for aortic aneurysm in adolescents and young adults increased from 0.12 (95% confidence interval [CI] 0.11, 0.14) to 0.13 (0.11, 0.14) per 100,000 population, with an AAPC of 0.08% (-0.08%, 0.25%). The ASDALYR rose from 7.25 (6.52, 8.30) to 7.35 (6.51, 8.37), with an AAPC of 0.07% (-0.09%, 0.23%). Both ASDR and ASDALYR are higher in males than females, with a declining trend in females. Higher Socio-Demographic Index (SDI) countries exhibit higher ASDR and ASDALYR compared to lower SDI countries, with a continuous decline observed in high SDI nations.

• #16

  https://link.springer.com/article/10.1007/s44197-025-00369-y

  In 2021, the ASDR and ASDALYR were 0.13 (95% confidence interval 0.11, 0.14) and 7.35 (6.51, 8.37) per 100,000 population, respectively. […] Both the global ASDR and ASDALYR have shown an upward trend in 2021 compared to 1990. […] The ASDR for females shows a declining trend, with an AAPC of -0.31 (95% confidence interval 0.46, -0.16). This decline is more pronounced in High SDI countries, whereas Low-middle SDI countries exhibit an increasing trend in ASDR, with an AAPC of 0.72 (0.57, 0.86). […] Globally, the ASDR and ASDALYR for early-onset aortic aneurysm can be attributed to seven risk factors, categorized into four main groups: tobacco risks (smoking), dietary risks (low vegetable intake, low fruit intake, and high sodium intake), metabolic risks (high systolic blood pressure and high body-mass index), and environmental risks (lead exposure). Overall, smoking is the primary attributable risk factor for aortic aneurysm across all regions, time periods, and genders.

• #17 Thoracic aortic aneurysm: Optimal surveillance and treatment | Cleveland Clinic Journal of Medicine

  https://www.ccjm.org/content/87/9/557

  Aneurysm of the thoracic aorta is less common than in the abdominal aorta, but it is clinically important because of the risk of rupture and death. […] Surveillance with various imaging tests is critical before and after intervention to guide treatment. […] Guidelines from several professional societies are available regarding surveillance and indications for intervention. […] Regular imaging surveillance is critical after diagnosis and after aneurysm interventions. […] There are no effective preventive strategies for TAA to date; thus, early detection, surveillance, and treatment are critical to improving outcomes. Guidelines are available. […] Patients with TAA should be referred to a cardiologist (and a surgeon, if approaching or exceeding surgical criteria) for optimal decision-making in surveillance and management.

• #18 E-077 Surveillance imaging of unruptured, untreated intracranial aneurysms: a review of the literature | Journal of NeuroInterventional Surgery

  https://jnis.bmj.com/content/10/Suppl_2/A87

  Intracranial aneurysms affect approximately 2% to 4% of the population, with aneurysmal rupture causing potentially devastating subarachnoid hemorrhage. […] Improved imaging technologies and more frequent intracranial screening has led to incidental findings of asymptomatic unruptured intracranial aneurysms (UIAs). […] These untreated UIAs are routinely followed with intracranial vascular imaging to monitor signs of growth or change in morphology, which may suggest an impending rupture. […] Current evidence is clear that different aneurysms carry differing risks of growth/rupture. […] The role of conservative management of UIAs is well established, particularly in the setting of increasing frequency of incidental UIA findings. […] It is generally agreed upon that the UIAs left untreated be monitored for signs of growth or morphologic change over time, but the specific frequency and duration of imaging has not been clearly defined.

• #19 Surveillance of Unruptured Intracranial Saccular Aneurysms Using Noncontrast 3D-Black-Blood MRI: Comparison of 3D-TOF and Contrast-Enhanced MRA with 3D-DSA | American Journal of Neuroradiology

  http://www.ajnr.org/content/early/2019/05/23/ajnr.A6080

  Patients with unruptured intracranial aneurysms routinely undergo surveillance imaging to monitor growth. […] This study aimed to evaluate the accuracy and reproducibility of a 3D noncontrast black-blood MR imaging technique for unruptured intracranial aneurysm measurement in comparison with 3D-TOF and contrast-enhanced MRA, using 3D rotational angiography as a reference standard. […] Clinical management of UIAs is based largely on aneurysm size and other features such as location, shape, and sac-to-neck ratio, with saccular aneurysms being the most common type. […] Most of those small aneurysms are followed with surveillance instead of immediate treatment. […] This study aimed to compare black-blood MR imaging with 3D-TOF/CE-MRA for aneurysm size measurements using 3DRA as a reference standard.

• #20 Should Surveillance of Unruptured Brain Aneurysms Be Selective?logo-32logo-40logo-60NEJM Journal WatchnejmJW_1L_RGB-b

  https://www.jwatch.org/na55077/2022/07/05/should-surveillance-unruptured-brain-aneurysms-be

  Unruptured brain aneurysms are present in about 3% of the general population. […] For small aneurysms, the optimal strategy for surveillance of aneurysm growth is uncertain. […] The authors found that to prevent one case of subarachnoid hemorrhage (SAH), the number needed to screen was as follows: U.S., 2222; U.K., 1910; Netherlands, 2040. […] In general, for the U.S. and U.K., no surveillance was the most cost-effective strategy, but in the Netherlands, annual surveillance until age 70 was considered reasonable. […] For individuals in the U.S. and U.K. at increased risk for aneurysm growth, annual surveillance or imaging in the first and fifth year was cost effective in individuals younger than 60 years. […] But in younger patients and especially those at increased risk for aneurysm growth, different imaging strategies could be reasonable.

• #21 Surveillance of Unruptured Intracranial Saccular Aneurysms Using Noncontrast 3D-Black-Blood MRI: Comparison of 3D-TOF and Contrast-Enhanced MRA with 3D-DSA | American Journal of Neuroradiology

  http://www.ajnr.org/content/early/2019/05/23/ajnr.A6080

  Our results support the use of noncontrast 3D-BB MR imaging for intracranial aneurysm surveillance. […] 3D-BB MR imaging achieves superior accuracy for intracranial aneurysm size measurements over 3D-TOF using 3DRA as the criterion standard, though all MR imaging measurements did not significantly differ from those with 3DRA. This noncontrast technique is promising for clinical surveillance of patients with unruptured intracranial aneurysms.

• #22 Updates on AAA screening and surveillance

  https://www1.racgp.org.au/ajgp/2018/may/aaa-screening-and-surveillance

  Screening and diagnostic surveillance of latent conditions have a profound impact on public healthcare expenditure and clinical outcomes. Abdominal aortic aneurysm (AAA) remains one of the hallmark pathologies in vascular surgery and an area of intense research interest. […] Screening and surveillance of AAA should be evidence-based and follow clinical guidelines; however, advances in treatment technology and epidemiological data have influenced results. Goals of care and cost-effectiveness should play central parts in screening and surveillance strategies. […] There are no official AAA screening programs in Australia, despite population screening programs in the UK and Sweden, where there is an 80% uptake, and numerous other European countries. Australian Medicare rules prohibit reimbursement for population screening studies; however, targeted screening of individual patients, on the basis of age, smoking history and family history of AAA, can be requested by any medical practitioner and is funded through the Medicare Benefits Schedule in Australia as part of clinically justified investigations.

• #23 Updates on AAA screening and surveillance

  https://www1.racgp.org.au/ajgp/2018/may/aaa-screening-and-surveillance

  On the basis of evidence showing substantial benefit, the US Preventive Services Task Force (USPSTF) recommends one-time ultrasonography screening for men aged 65-75 years who have ever smoked. […] The justification for screening programs has been further revisited by the publication of a 2017 meta-analysis of all reported trials, which concluded that screening reduces AAA-related deaths (odds ratio [OR] 0.66, 95% CI: 0.47, 0.93, P 0.02). […] Targeted population screening has been welcomed in some countries as there is evidence for a reduction in AAA-related deaths and improvement in cardiovascular outcomes in patients on surveillance, particularly men.

• #24 Guidance for Surveillance of Isolated Common Iliac Artery and Small Abdominal Aortic Aneurysms

  https://consultqd.clevelandclinic.org/guidance-for-surveillance-of-isolated-common-iliac-artery-and-small-abdominal-aortic-aneurysms

  Most small abdominal aortic aneurysms (AAAs) and isolated common iliac artery aneurysms (CIAAs) can safely be monitored every three years with duplex ultrasound, with larger ones needing more frequent surveillance. […] The current recommendations from professional societies are based on a large amount of low-quality data and information from older databases, says Cleveland Clinic vascular surgeon Jarrad Rowse, MD, lead author of the study on small AAAs and a co-author of the study on CIAAs. […] Isolated CIAAs i.e., those not associated with a concomitant AAA are rare, constituting only about 7% of all aortoiliac aneurysms. […] The European Society for Vascular Surgery recommends monitoring every three years for CIAAs 2.0 to 2.9 cm in diameter, and annually for larger ones. […] Current Society for Vascular Surgery guidelines for monitoring small AAAs every three years for aneurysm diameters of 3.0 to 3.9 cm, and annually for diameters of 4.0 to 4.9 cm are based on low-quality evidence and provide no patient-specific guidance.

• #25 Guidance for Surveillance of Isolated Common Iliac Artery and Small Abdominal Aortic Aneurysms

  https://consultqd.clevelandclinic.org/guidance-for-surveillance-of-isolated-common-iliac-artery-and-small-abdominal-aortic-aneurysms

  The authors write that their findings support the following surveillance schedule: For diameters 3.0 to 3.9 cm, every three years; For diameters 4.0 to 4.9 cm, annually for men; For women approaching the 5.0 cm threshold for intervention (threshold is 5.5 cm for men), closer surveillance is recommended.

• #26

  https://www.gov.uk/government/publications/aaa-screening-programmes-in-the-uk-10-year-effectiveness-review/uk-aaa-screening-programmes-10-year-effectiveness-review

  The aim of this report was to assess the effectiveness of population screening for AAA in men aged 65, by reviewing the AAA screening programmes across the UK between 2013 and 2023. […] The aim was to review the data collected by the 4 UK programmes in England, Scotland, Wales and Northern Ireland. […] The AAA screening programmes in the UK aim to reduce AAA-related deaths in men by identifying aneurysms at a stage before rupture is likely to have occurred. Surveillance and treatment can then be offered at the appropriate stage to reduce the risk of AAA rupture, emergency hospital treatment, and death. […] It can be concluded that the AAA screening programmes in the UK are effective and contribute substantially to ongoing reductions in AAA-related mortality (deaths). […] The main finding of this review is the steady decline in deaths in men from rAAA during the decade of study.

• #27

  https://www.gov.uk/government/publications/aaa-screening-programmes-in-the-uk-10-year-effectiveness-review/supplementary-data-tables

  Men with small (3.0cm to 4.4cm) aneurysms are offered annual surveillance scans and men with medium aneurysms (4.5cm to 5.4cm) are offered quarterly scans. […] The graphs in Figure A5 shows how uptake of the annual surveillance scan remained consistently high at above 80% in England, Wales and Northern Ireland between 2013 to 2023, apart from in 2020 to 2021 during the COVID19 pandemic when a dip in uptake can be seen in all 3 nations. There is a greater decrease in uptake seen in Wales during this time. […] The graph in Figure A7 shows how the coverage of the annual surveillance scan remained consistently high above 80% in England, Wales and Northern Ireland between 2013 to 2023, apart from in 2020 to 2021 during the COVID19 pandemic when a dip in coverage can be seen in all 3 nations. There is a greater decrease in coverage seen in Wales during this time. […] The graph in Figure A8 shows how the coverage of the quarterly surveillance scan remained consistently high above 80% in England, Scotland and Northern Ireland between 2013 to 2023, apart from in 2020 to 2021 during the COVID19 pandemic when a dip in coverage can be seen in all 3 nations.

• #28 New abdominal aortic aneurysm surveillance program saves patient’s life

  https://health.ucdavis.edu/news/headlines/new-abdominal-aortic-aneurysm-surveillance-program-saves-patients-life/2023/01

  In its first eight months, the program has identified over 11,600 patients with some mention of AAA who could benefit from monitoring. Over 10,600 patients were reviewed and 950 patients who were lost to care are now under active surveillance and management by nurse navigators. […] Leveraging the Illuminate software, our nurse navigators have been able to efficiently review patients with aortic aneurysms and identify patients overdue for follow up, added Hickerson. This program greatly illustrates the high quality of care delivered at UC Davis Health, as we have invested in technology and services that provide follow up and thus been able to save lives.

• #29 Biostatistics Grant for UCSF Aims to Catch Aneurysms Before They Rupture | Epidemiology & Biostatistics

  https://epibiostat.ucsf.edu/news/biostatistics-grant-ucsf-aims-catch-aneurysms-they-rupture

  A new UCSF study will take data gathered from a new machine and crunch it using modern machine learning to help predict which cerebral aneurysms are likely to rupture. […] Only about 6 percent of people develop cerebral aneurysms, which, in most cases, rarely cause symptoms and do not require invasive treatment. […] Successfully predicting which aneurysms are likely to rupture and then removing those could prevent serious injury and death. […] The risk of rupture also depends on the pressure around the aneurysm, Jiang said. […] Recent evaluations of UIAs using 4D Flow suggest certain hemodynamic variables may greatly impact aneurysm growth or rupture. […] We propose 4D Flow as a non-invasive method to measure the blood flow around aneurysms so that we can extract some features from the blood flow to say whether these features are associated with the growth trajectory of the aneurysms, Jiang said. […] Plugging that large volume of data from 4D Flow into a machine-learning model may yield enough information to decide whether the aneurysm poses a risk of rupture. […] The ability to use machine learning models to help predict what an aneurysm might do is exciting, Jiang said.

• #30 Postoperative Abdominal Aortic Aneurysm (AAA) Surveillance < Yale School of Medicine

  https://medicine.yale.edu/news-article/publication-and-the-pi-postoperative-abdominal-aortic-aneurysm-surveillance/

  Yale Department of Surgerys Edouard Aboian, MD, evaluated abdominal aortic aneurysm surveillance in postoperative settings. […] We compared the standard for postoperative abdominal aortic aneurysm surveillance, maximum aortic diameter, to volumetric analysis of abdominal aortic aneurysm. […] The change of volume was more sensitive compared to diameter change, especially after endovascular abdominal aortic aneurysm repair. […] Our volumetric aneurysm analysis confers that you can detect that and potentially intervene early on. […] Volumetric evaluation has less interobserver variability compared to maximum diameter because diameter can be measured in different planes, oftentimes not orthogonal to the centerline of flow, and that may introduce some false findings in aortic aneurysm behavior. […] We are developing predictive clinical tools for a more sensitive analysis of aneurysm post intervention.

• #31 Integrated Aortic Program | Thoracic Aneurysm Program

  https://www.valleyhealth.com/services/integrated-aortic-program

  Living with an aortic aneurysm can be stressful, but when managed properly, patients can enjoy an excellent quality of life. […] Our well-established diagnostic, surgical and surveillance program offers comprehensive care for patients with aortic aneurysm. […] Valleys Integrated Aortic Program offers regular follow-up and careful management to ensure you receive high quality care based on the latest evidence. […] Valley currently has over 1,700 patients under surveillance in the program, ranging from 17 to 90 years of age. […] The First-Degree Relative program provides screening, imaging and long-term surveillance for those individuals who have a relative diagnosed with a thoracic aneurysm. […] For most patients, regular surveillance combined with risk factor management is enough treatment to safely manage their aneurysm.

• #32 Integrated Aortic Program | Thoracic Aneurysm Program

  https://www.valleyhealth.com/services/integrated-aortic-program

  Each patient is seen regularly to monitor their aorta. […] Education is an important aspect of care, and we offer education on nutrition, stress management, and safe exercise with a thoracic aneurysm. […] Valleys Integrated Aortic Program has patient support groups that meet regularly online and in person. […] Through our First Degree Relative program, we also monitor family clusters of aortic aneurysms.

• #33 < ?php wp_title( '|', true, 'right' ); ?>

  https://surgicalneurologyint.com/surgicalint-articles/epidemiological-analysis-of-1404-patients-with-intracranial-aneurysm-followed-in-a-single-brazilian-institution/

  Several epidemiological studies evaluated the prevalence of aneurysms and the risk of rupture. Among the observed factors, aneurysm location, age, female gender, hypertension, history of SAH, aneurysm size, and symptomatic aneurysms have an increased risk of rupture. Geographic location, probably due to genetics specific environmental factors, is another important risk factor. Finnish or Japanese patients have a greater risk of aneurysm rupture than the European or North American population. Although geographic location is an important risk factor for the development and rupture of intracranial aneurysm, few studies on this subject are performed in Brazil or in Latin America. […] In this study, we sought to analyze the epidemiology of intracranial aneurysms regarding location, gender, age, presence of multiple aneurysms, and comorbidities in the Brazilian population. These data might bring to light singular epidemiologic characteristics regarding intracranial aneurysm in the Brazilian and Latin American population.

• #34 < ?php wp_title( '|', true, 'right' ); ?>

  https://surgicalneurologyint.com/surgicalint-articles/epidemiological-analysis-of-1404-patients-with-intracranial-aneurysm-followed-in-a-single-brazilian-institution/

  Our results showed that most of the aneurysms found were between 5 mm and 10 mm in size. The previous studies have shown a higher rupture rate between aneurysms larger than 5 mm in size. However, when we analyzed the relationship between the size of the aneurysm and hypertension, smoking status, or gender, we did not find a significant correlation. […] Multiple aneurysms were found in 36.4% of patients, a slightly higher prevalence than the previous studies have shown. Multiplicity was associated with female gender and smoking. Data like these provide relevant data on the distribution of aneurysms prevalence worldwide, help to understand specific features of a given population, and delineate public health policies. Significant limitations of our study include being conducted in a single institution, although a referral center for cerebrovascular diseases. However, we encompass a large number of individuals and have provided important insights into cerebral aneurysm epidemiological characteristics for Brazilian and Latin American population.

• #35

  https://scispace.com/papers/problematique-des-hemorragies-meningees-dans-les-pays-en-17yvma0f6h

  Cerebral aneurysms in Africa: A scoping review. The authors aimed to describe the landscape of cerebral aneurysms in Africa based on published literature to help understand the epidemiology, management, and prognosis of cerebral aneurysm care in Africa. […] Surgical aneurysm repair of aneurysmal subarachnoid hemorrhage in Sub-Saharan Africa: The state of training and management. The most common challenges with lack of training for neurosurgical aneurysm clipping were scarce scholarship and collaboration with training centers from high-income countries. […] Global Disparities in the Presentation and Management of Aneurysmal Subarachnoid Hemorrhage (aSAH): A Review and Analysis. This systematic review and meta-analysis of 10,553 aSAH patients reveals significant global disparities in demographics, treatment methods, and outcomes, with high-income countries exhibiting higher rates of endovascular coil embolization and lower rates of surgical clipping.

• #36 < ?php wp_title( '|', true, 'right' ); ?>

  https://surgicalneurologyint.com/surgicalint-articles/epidemiological-analysis-of-1404-patients-with-intracranial-aneurysm-followed-in-a-single-brazilian-institution/

  Epidemiological analysis of 1404 patients with intracranial aneurysm followed in a single Brazilian institution […] Background: We sought to evaluate the epidemiology of intracranial aneurysms in relation to location, gender, age, presence of multiple aneurysms, and comorbidities in the Brazilian population. […] Methods: We performed a prospective analysis of a cohort of 1404 patients diagnosed with intracranial aneurysm admitted to the Hospital das Clinicas of the University of Sao Paulo, a referral hospital for the treatment of cerebrovascular diseases in Brazil. Patients admitted between September 2009 and September 2018 with radiological diagnosis of intracranial aneurysm were included in the study. […] Results: A total of 2251 aneurysms were diagnosed. Females accounted for 1090 aneurysms (77.6%) and the mean age at diagnosis was 54.9 years (ranging 15-88). The most common location was middle cerebral artery (MCA) with 593 aneurysms (26.3%) followed by anterior cerebral artery (ACA) with 417 aneurysms (18.5%) and internal carotid artery in the posterior communicating segment with 405 aneurysms (18.0%). Males had higher rates of ACA aneurysms (29.7%) while females had higher rates of MCA aneurysms (26.1%). The occurrence of multiple aneurysms was associated with female gender.

• #37 Giant cerebral aneurysm | Radiology Reference Article | Radiopaedia.org

  https://radiopaedia.org/articles/giant-cerebral-aneurysm?lang=us

  Giant cerebral aneurysms account for ~5% of all intracranial aneurysms. They occur in the 5th-7th decades and are more common in females. […] Compared to non-giant cerebral aneurysms there is an increased incidence in the posterior circulation (~35%).

• #38 Aneurysm – Wikipedia

  https://en.wikipedia.org/wiki/Aneurysm

  Incidence rates of cranial aneurysms are estimated at between 0.4% and 3.6%. Those without risk factors have expected prevalence of 23%. In adults, females are more likely to have aneurysms. They are most prevalent in people ages 35 60 but can occur in children as well. Aneurysms are rare in children with a reported prevalence of .5% to 4.6%. The most common incidence is among 50-year-olds, and there are typically no warning signs. Most aneurysms develop after the age of 40. […] Incidence rates are two to three times higher in males, while there are more large and giant aneurysms and fewer multiple aneurysms. Intracranial hemorrhages are 1.6 times more likely to be due to aneurysms than cerebral arteriovenous malformations in whites, but four times less in certain Asian populations. Most patients, particularly infants, present with subarachnoid hemorrhage and corresponding headaches or neurological deficits. The mortality rate for pediatric aneurysms is lower than in adults.

• #39 Epidemiology and outcomes of pediatric intracranial aneurysms: comparison with an adult population in a 30-year, prospective database in: Journal of Neurosurgery: Pediatrics Volume 28 Issue 6 (2021) Journals

  https://thejns.org/pediatrics/view/journals/j-neurosurg-pediatr/28/6/article-p685.xml

  Pediatric intracranial aneurysms are significantly different from adult aneurysms in terms of sex, presentation, location, size, and outcomes. Future prospective studies will better characterize long-term aneurysm recurrence, rebleeds, and de novo aneurysm occurrences. The authors currently favor microsurgical over endovascular treatment for pediatric aneurysms.

• #40 Epidemiology and outcomes of pediatric intracranial aneurysms: comparison with an adult population in a 30-year, prospective database in: Journal of Neurosurgery: Pediatrics Volume 28 Issue 6 (2021) Journals

  https://thejns.org/pediatrics/view/journals/j-neurosurg-pediatr/28/6/article-p685.xml

  Pediatric intracranial aneurysms are rare. Most large series in the last 15 years reported on an average of only 39 patients. The authors sought to report their institutional experience with pediatric intracranial aneurysms from 1991 to 2021 and to compare pediatric patient and aneurysm characteristics with those of a contemporaneous adult cohort. […] Pediatric ( 18 years of age) and adult patients with one or more intracranial aneurysms were identified in a prospective database. Standard epidemiological features and outcomes of each pediatric patient were retrospectively recorded. These results were compared with those of adult aneurysm patients managed at a single institution over the same time period. […] From a total of 4500 patients with 5150 intracranial aneurysms admitted over 30 years, there were 47 children with 53 aneurysms and 4453 adults with 5097 aneurysms; 53.2% of children and 36.4% of adults presented with a subarachnoid hemorrhage (SAH). Pediatric aneurysms were significantly more common in males, more likely giant ( 25 mm), and most frequently located in the middle cerebral artery. Overall, 85.1% of the pediatric patients had a modified Rankin Scale score 2 at the last follow-up (with a mean follow-up of 65.9 months), and the pediatric mortality rate was 10.6%; all 5 patients who died had an SAH. The recurrence rate of treated aneurysms was 6.7% (1/15) in the endovascular group but 0% (0/31) in the microsurgical group. No de novo aneurysms occurred in children (mean follow-up 5.5 years).

• #41

  https://link.springer.com/article/10.1007/s00701-019-03812-9

  The treatment of ruptured posterior circulation aneurysms remains challenging despite progresses in the endovascular and neurosurgical techniques. […] To provide epidemiological characterization of subjects presenting with ruptured posterior circulation aneurysms in Switzerland and thereby assessing the treatment patterns and neurological outcomes. […] From 2009 to 2014, we included 264 patients with ruptured posterior circulation aneurysms. Endovascular occlusion was the most common treatment in all 3 groups (72% in the upper third, 68% in the middle third, and 58.8% in the lower third). […] In this study, endovascular occlusion was the principal treatment, with a favorable outcome for two-thirds of patients at discharge and at long term. These results are similar to high volume neurovascular centers worldwide, reflecting the importance of centralized care at specialized neurovascular centers.

• #42 Microsurgical Management of Posterior Circulation Aneurysms: A Retrospective Study on Epidemiology, Outcomes, and Surgical Approaches

  https://www.mdpi.com/2076-3425/12/8/1066

  Posterior circulation aneurysms have been regarded as the most challenging for endovascular coiling and microsurgical occlusion. […] Although posterior circulation aneurysms account for, at most, 15% of all intracranial aneurysms, posterior circulation aneurysms have a higher risk of rupture and a worse clinical outcome than anterior circulation aneurysms. […] With advances in endovascular techniques and increased clinician experience for intracranial aneurysms, the rate of endovascular coiling has been gradually increasing. […] However, the microsurgical treatment appears superior for lower rates of rebleeding, lower rates of recurrence, and higher rates of aneurysm obliteration. […] Hence, due to the rarity of microsurgical occlusion for posterior circulation aneurysms, we summarized 50 patients with posterior circulation aneurysms who underwent microsurgical treatment at our hospital between 2016 and 2021 to assess this therapeutic option and corresponding surgical approaches.

• #43 Microsurgical Management of Posterior Circulation Aneurysms: A Retrospective Study on Epidemiology, Outcomes, and Surgical Approaches

  https://www.mdpi.com/2076-3425/12/8/1066

  The most common presentation was headache. […] Our results indicated that the mortality was 8%, falling within the above range. […] The risk of poor clinical outcomes and death (mRS 4–6) at discharge was 32%, dropping to 29% at six months. […] Our cases were admitted with higher Hunt and Hess grades and percentage of ruptured aneurysms. […] The percentage of good clinical outcomes increased to 72.34% at six months, with three patients lost to follow-up. […] With the mean follow-up period of 3.57 ± 1.72 years, none of the patients had a recurrence of aneurysm. […] In conclusion, direct clipping and bypass should complement each other as safe and effective treatment approaches in common or complex aneurysms.

• #44 Hepatic hemangioma | Radiology Reference Article | Radiopaedia.org

  https://radiopaedia.org/articles/hepatic-haemangioma-3?lang=us

  Hepatic hemangiomas are much more common in females, with an F:M of up to 5:1. They are rarely seen in young children, but infantile hepatic hemangioma is the most common, benign hepatic vascular tumor in infants. […] Hepatic hemangiomas are thought to be congenital in origin, non-neoplastic, and are almost always of the cavernous subtype. Blood supply is predominantly hepatic arterial, similar to other liver tumors. A peripheral location within the liver is most common.

• #45 Pathology Outlines – Dermatofibroma (cutaneous fibrous histiocytoma)

  https://www.pathologyoutlines.com/topic/softtissuebfh.html

  Common […] All races […] All ages; most common in third and fourth decades […] F > M […] Aneurysmal and hemosiderotic variants are both characterized by numerous multinucleate cells and prominent hemosiderin deposition due to red blood cell extravasation; distinction between these two is the pseudovascular spaces with blood in aneurysmal type.

• #46 Optimal surveillance and treatment of renal and splenic artery aneurysms | Cleveland Clinic Journal of Medicine

  https://www.ccjm.org/content/87/12/755

  Aneurysms of the renal artery and splenic artery are uncommon but clinically important, as they pose a risk of rupture with a high fatality rate. Indications for surgical or endovascular repair are based on aneurysm location and risk factors for rupture, such as aneurysm size, growth, and associated conditions, while medical management is also important. Regular surveillance with imaging is critical before and after intervention to guide treatment. […] Regular imaging surveillance is critical after both diagnosis and interventions. […] If a renal artery aneurysm is found but does not meet the criteria for intervention, repeat imaging at 1, 6, and 12 months and then annually has been recommended by some experts, although guidelines are lacking. […] If intervention is not planned, surveillance is recommended at 6 months after diagnosis and then annually.

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