Materiały źródłowe

• #1 Liver cancer – Symptoms and causes – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/liver-cancer/symptoms-causes/syc-20353659

  Most people don’t have signs and symptoms in the early stages of primary liver cancer. When signs and symptoms do appear, they may include unintentional weight loss, loss of appetite, upper abdominal pain, nausea and vomiting, general weakness and fatigue, abdominal swelling, jaundice where your eyes and skin turn yellow, and white, chalky stools. […] Most people don’t have signs and symptoms in the early stages of primary liver cancer. When signs and symptoms do appear, they may include: Losing weight without trying, Loss of appetite, Upper abdominal pain, Nausea and vomiting, General weakness and fatigue, Abdominal swelling, Yellow discoloration of your skin and the whites of your eyes (jaundice), White, chalky stools.

• #2 18 Top Liver Cancer Symptoms & Signs | MD Anderson Cancer Center

  https://www.mdanderson.org/cancer-types/liver-cancer/liver-cancer-symptoms.html

  Primary liver cancer usually does not cause symptoms in the early stages. When it does have symptoms, they vary from person to person. As the tumor grows, it may cause: […] Unintended weight loss […] Pain in the right side of the upper abdomen or around the right shoulder blade […] Loss of appetite […] Swelling or bloating in the abdomen […] Feeling of fullness after a small meal […] Hard lump below the ribs on the right side […] Tiredness or weakness […] Nausea or vomiting […] Jaundice: Yellowing of the skin and whites of the eyes. Jaundice is caused by high levels of bilirubin, a yellow pigment that results from the breakdown of red blood cells. It is usually processed by the liver and passes through the bile ducts before being excreted. Excess bilirubin can be a sign of liver or bile duct malfunction.

• #3 End stage liver cancer: Symptoms timeline and life expectancy

  https://www.medicalnewstoday.com/articles/end-stage-liver-cancer-timeline

  Symptoms that may indicate end stage liver cancer include increased fatigue, abdominal pain, and jaundice, which is the yellowing of the skin and mucus membranes. […] The following symptoms may indicate end stage liver cancer. Certain symptoms may also indicate that a person is nearing the end of life. […] Some of the most common symptoms of late-stage liver cancer are: unintended weight loss, appetite loss, a feeling of fullness even after a small meal, vomiting, nausea, enlarged liver, enlarged spleen, abdominal pain, pain near the right shoulder blade, itching, jaundice. […] People with cancer who are nearing the end of life may have the following symptoms: fatigue and extreme tiredness, shortness of breath or irregular breathing, pain, coughing, constipation, difficulty swallowing, delirium and hallucinations, decreased urine, which may also be darker than usual, changes in heart rate, decreased blood pressure, cold hands and feet, which may look blotchy or blue, a rattling sound when breathing, which is due to saliva or fluids collecting in the throat and airways, muscle jerking, fever, heavy bleeding.

• #4 Signs and Symptoms of Liver Cancer | American Cancer Society

  https://www.cancer.org/cancer/types/liver-cancer/detection-diagnosis-staging/signs-symptoms.html

  Signs and symptoms of liver cancer often do not show up until the later stages of the disease, but sometimes they may show up sooner. If you go to your doctor when you first notice symptoms, your cancer might be diagnosed earlier, when treatment is most likely to be successful. […] Some of the most common symptoms of liver cancer are: Weight loss (without trying), Loss of appetite, Feeling very full after a small meal, Nausea or vomiting, An enlarged liver, felt as fullness under the ribs on the right side, An enlarged spleen, felt as fullness under the ribs on the left side, Pain in the abdomen (belly) or near the right shoulder blade, Swelling or fluid buildup in the abdomen (belly), Itching, Yellowing of the skin and whites of the eyes (jaundice), Fever, Enlarged veins on the belly that can be seen through the skin, Abnormal bruising or bleeding.

• #5 Symptoms of liver cancer – NHS

  https://www.nhs.uk/conditions/liver-cancer/symptoms/

  Liver cancer may not have any symptoms, or they might be hard to spot. […] The symptoms are the same if the liver cancer starts in the liver (primary liver cancer) or spreads from another part of the body (secondary liver cancer). […] Symptoms of liver cancer can include: the whites of your eyes turning yellow or your skin turning yellow, which may be less obvious on brown or black skin (jaundice) you may also have itchy skin, darker pee and paler poo than usual. […] loss of appetite or losing weight without trying to. […] feeling tired or having no energy. […] feeling generally unwell or having symptoms like flu. […] a lump in the right side of your tummy. […] Other symptoms can affect your digestion, such as: feeling or being sick. […] pain at the top right side of your tummy or in your right shoulder.

• #6 Metastatic Stage 4 Liver Cancer: Symptoms and What to Expect

  https://www.cancercenter.com/cancer-types/liver-cancer/types/metastatic-liver-cancer

  Liver cancer symptoms often do not appear in the early stages. As a result, liver cancer tends to be diagnosed at a more advanced stage. […] The symptoms of metastatic liver cancer vary depending on where new tumors form. For example, if the liver cancer spreads to the bones, it may cause bone fractures. […] Common symptoms of stage 4 liver cancer include: abdominal pain, pain occurring near the right shoulder blade or in the upper abdomen, loss of appetite, weight loss or nausea, abdominal swelling or bloating in the abdomen, yellowing of the skin and eyes (jaundice), ongoing fatigue or weakness, unexplained fever. […] Patients with stage 4 liver cancer may experience worsening symptoms such as increasing jaundice, pain, difficulty eating and strong fatigue.

• #7 Liver Cancer: Symptoms, Signs, Causes & Treatment

  https://my.clevelandclinic.org/health/diseases/9418-liver-cancer

  The three types of liver cancer cause similar symptoms. Liver cancer symptoms may include: Dark-colored pee or grey or pale poop […] Unexplained bruising […] Fatigue […] Fever […] Hard bump or lump on the right side of your body just below your rib cage […] Itchy skin […] Loss of appetite or unexplained weight loss […] Nausea and vomiting […] Upper abdominal pain on the right side of your body or swollen abdomen […] Yellowing of your skin and the whites of your eyes from jaundice. […] Unfortunately, you can have very early liver cancer without any symptoms. If you’re concerned, ask a healthcare provider to assess your risk. They may recommend you have tests that check on liver health and function. […] Cancer staging is how healthcare providers diagnose disease and plan treatment. Providers use the Barcelona Clinic Liver Cancer system (BCLC) to stage liver cancer. This system considers factors like your symptoms, liver function and tumor size.

• #8

  https://www.mountelizabeth.com.sg/conditions-diseases/liver-cancer/symptoms-causes

  It can be confusing to distinguish the symptoms of liver cancer as most of them are similar to symptoms of other health conditions. […] In addition, liver cancer often does not present symptoms in its early stage. It is best to consult a doctor if you experience any of the following liver cancer symptoms: […] Upper abdominal pain The pain of liver cancer is typically felt on the upper right portion of the abdomen. It sometimes extends to the back or can be felt in the lower right part of the rib cage. […] Abdominal swelling The growing cancer causes the liver to get bigger, causing the right side of the abdomen to swell. The cancer can also increase the pressure in the liver, causing blood to back up in the veins. This can cause ascites (fluid collecting in spaces within the abdomen), leading to abdominal swelling.

• #9 What are the Symptoms and Signs of Liver Cancer?

  https://www.cancercenter.com/cancer-types/liver-cancer/symptoms

  Other signs and symptoms include: Fever, Dark urine, Pale/chalky stools, Easy bruising or bleeding, Fatigue, Weakness, Unexplained and unintentional weight loss, Poor appetite, Enlarged spleen felt as a mass under the ribs on the left side, Feeling of fullness after eating a small amount of food, Nausea, Vomiting. […] Many of these symptoms may be caused by other types of benign liver infections or diseases. In the case of liver cancer, the symptoms may continue to evolve and worsen as the tumor grows and the disease advances. If the patient notices potential symptoms, its important to see a doctor for an accurate diagnosis. Pain is especially common in patients with advanced-stage liver cancer. Because the cancer has likely spread by that point, the patient may be experiencing pain in both the primary liver cancer site and in areas the cancer has spread.

• #9 What are the Symptoms and Signs of Liver Cancer?

  https://www.cancercenter.com/cancer-types/liver-cancer/symptoms

  In its early stages, liver cancer may not show any apparent signs and symptoms. Over time, though, as a tumor in the liver grows, a patient may see or feel it. Or a doctor may see or feel it during a checkup. At this point, the cancer may be advanced and more difficult to treat. […] The symptoms of liver cancer may differ for each person, and any one of these symptoms may be caused by other conditions. Also, while its true that liver cancer symptoms are more common in the later stages, some patients develop them earlier. […] Some common early warning signs include: Pain in the upper abdomen on the right side or near the right shoulder blade that tends to remain consistent and does not come and go, Abdominal swelling (ascites) or bloating in the abdomen that develops as a mass, Enlarged liver (hepatomegaly) felt as a mass under the ribs on the right side, Jaundice (yellowing of the skin and eyes).

• #10 Bile Duct and Liver Cancer Symptoms | Banner Health

  https://www.bannerhealth.com/services/cancer/cancer-type/liver-cancer/symptoms-and-types

  Liver and bile duct cancers can be hard to treat in more advanced stages because early symptoms often go unnoticed. Many patients are diagnosed at a later stage when treatment options are more limited. […] Liver and bile duct cancer symptoms often do not appear in early stages of the disease and may only become noticeable as the disease progresses. Additionally, small tumors can be difficult to detect because the liver and bile ducts are protected by the ribs. When symptoms do appear, they may include: Upper abdominal pain or pain on the right side below the ribs, Back pain or pain near the right shoulder blade, Abdominal swelling or fluid buildup, Visible swollen veins under the abdominal skin, Enlarged liver and/or spleen, Yellowing of the skin and eyes (jaundice), White, chalky stools, Dark urine, Fever, Night sweats, Itching, Unexplained weight loss, Feeling full after eating a small meal, Low blood sugar levels, Nausea and vomiting.

• #11

  https://www.mountelizabeth.com.sg/conditions-diseases/liver-cancer/symptoms-causes

  Nausea and vomiting Liver tumours are more likely to cause nausea and vomiting. […] Jaundice When cancer blocks the bile duct or when the liver is no longer functioning properly, bilirubin can build up in the blood and lead to jaundice. […] White, chalky stools Liver cancer can cause white, chalky stools caused by lack of a liver enzyme called bile. […] Weight loss If you dont know why you are losing more than 10% of your body weight, consult a doctor.

• #12 HCC symptoms – Liver Cancer UK

  https://livercanceruk.org/liver-cancer-information/types-of-liver-cancer/hcc/signs-and-symptoms/

  Swelling may be caused by an enlarged liver or by fluid collecting in the tummy (abdomen). The liver is responsible for making proteins that keep fluid in the bloodstream. Without these, fluid tends to seep out and can pool around the abdominal organs. Doctors call this ascites (say: a-site-eez). You may also notice other swelling, such as puffy ankles. […] Jaundice (say: jawn-diss) is caused by the cancer blocking one or more of the bile ducts. Bile then gets backed up in the liver, so you can’t get rid of bilirubin. This waste product from recycling red blood cells is normally processed by the liver. The bilirubin collects in the bloodstream and other body tissues, causing yellowing. […] Other symptoms related to jaundice are: […] itching, caused by a build up of bile salts in the skin […] very dark wee from bilirubin in the urine […] pale, putty-coloured poo (bowel movements) because bile salts are not passing through and colouring the poo brown.

• #13 Liver Cancer: Signs and Symptoms

  https://www.health.com/liver-cancer-symptoms-8606521

  Liver cancer occurs when cancer cells begin to grow abnormally and form tumors in the liver. […] Most people dont experience symptoms in the early stages of liver cancer, but as the condition progresses, symptoms may include an abdominal lump, loss of appetite, and pain. […] Liver cancer may not show any signs in the early stages. As your cancer progresses, common symptoms may include: Abdominal lump: A lump or mass on the right side of your abdomen under your rib cage or on the left side of your body if your spleen enlarges. […] Pain: Discomfort or aching in the right upper quadrant of the abdomen or near the right shoulder blade. The pain comes from the invasion of the liver tumor into nearby structures. […] Loss of appetite: You might have less interest in eating or feel full after a small meal.

• #14 What is The Last Stage Of Liver Cancer? – Dr Praveen Kammar

  https://drpraveenkammar.com/blogs/what-is-the-last-stage-of-liver-cancer/

  Liver cancer can occur when the liver cells grow abnormally, out of control. […] The last stage cancer or stage 4 liver cancer is the one that has spread to the nearby lymph nodes and/or distant sites within the body. […] This end-stage liver cancer is complicated because most patients have significant liver damage that ultimately limits the organs function. […] Reduced liver function may cause severe, even life-threatening conditions and have implications when choosing treatment options. […] Symptoms of last-stage liver cancer include: Jaundice, Bleeding from trivial injuries, The buildup of fluid in the abdomen and legs, Reduced brain function (problems with memory and concentration), Muscle cramps, Trouble sleeping at night, Extreme fatigue, Intense itching, Decreased appetite. […] When the liver function declines in end-stage liver cancer, certain medications further harm the liver or build up in the bloodstream, causing severe side effects. This requires immediate medical attention.

• #15 What Are the Symptoms of Last Stage Liver Cancer? – Dr. Vijay Karan Reddy

  https://drvijaykaranreddy.com/blog/what-are-the-symptoms-of-last-stage-liver-cancer

  Liver cancer, particularly in its final stages, presents a range of severe symptoms that significantly impact a patient’s quality of life. […] Last stage, liver cancer, also known as Stage IV liver cancer, is when the cancer has spread beyond the liver to other parts of the body. This stage is characterized by more severe symptoms and typically requires palliative care to manage pain and improve the patients quality of life. […] One of the most common and distressing symptoms is severe pain in the upper abdomen. This pain can radiate to the back and shoulder. […] The skin and whites of the eyes turn yellow due to the livers inability to process bilirubin. […] Significant, unexplained weight loss is a common symptom as the body uses more energy to fight the disease. […] Patients often experience a marked decrease in appetite, leading to further weight loss and weakness.

• #16 What Are the Symptoms of Last Stage Liver Cancer? – Dr. Vijay Karan Reddy

  https://drvijaykaranreddy.com/blog/what-are-the-symptoms-of-last-stage-liver-cancer

  Fluid accumulation in the abdomen causes swelling and discomfort. […] Extreme tiredness and lack of energy are frequent as the bodys resources are depleted. […] These symptoms can result from the liver’s impaired function. […] Accumulation of toxins in the blood can affect brain function, leading to confusion or encephalopathy. […] Recognizing the symptoms of last stage liver cancer and understanding the available treatment options is essential for managing this challenging condition.

• #17 Bile Duct and Liver Cancer Symptoms | Banner Health

  https://www.bannerhealth.com/services/cancer/cancer-type/liver-cancer/symptoms-and-types

  Symptoms of end-stage liver disease may include: Easy bleeding or bruising, Intense itching, Loss of appetite, Nausea, Problems with concentration and memory, Recurrent jaundice (yellowing of skin and eyes), Abdominal and leg swelling. […] Experiencing these symptoms doesn’t necessarily mean you have liver cancer, but if you’re concerned, it’s important to speak with your doctor.

• #18 HCC symptoms – Liver Cancer UK

  https://livercanceruk.org/liver-cancer-information/types-of-liver-cancer/hcc/signs-and-symptoms/

  This isn’t really a symptom of HCC, but rather a complication of advanced liver disease. Doctors call it hepatic encephalopathy (say: en-keff-al-op-ath-ee). Toxins build up in the blood because the liver is not working well enough to remove them. They can cause mental changes, such as confusion, forgetfulness and poor concentration. If not treated people can become drowsy and confused.

• #19 Liver cancer (Primary)

  https://www.cancervic.org.au/cancer-information/types-of-cancer/liver_cancer/managing-symptoms.html

  Primary liver cancer can cause various symptoms, but there are ways to manage them. With advanced cancer, the palliative care team may be involved in managing symptoms. […] Jaundice can cause yellowing of the skin and whites of the eyes, pale faeces, dark urine and itchy skin (often worse at night). […] In some people, liver cancer can cause pain, particularly in the upper right area of the abdomen (belly) and, sometimes, in the right shoulder. […] Because the liver plays a key role in the digestive system, cirrhosis and cancer in the liver can affect how much you eat, and you may lose weight. […] Ascites is when fluid builds up in the abdomen. […] Many people with primary liver cancer experience fatigue. This is different to normal tiredness as it doesnt always go away with rest or sleep. […] Chronic liver disease may cause toxic substances to build up in the blood, which can affect how your brain functions. Called hepatic encephalopathy, it can lead to confusion or disorientation and, in severe cases, coma.

• #20 Metastatic Liver Cancer – Liver and Gallbladder Disorders – Merck Manual Consumer Version

  https://www.merckmanuals.com/home/liver-and-gallbladder-disorders/tumors-of-the-liver/metastatic-liver-cancer

  Weight loss and a poor appetite may be the first symptoms. […] Often, the first symptoms are vague. They include weight loss, poor appetite, and sometimes fever. Typically, the liver is enlarged and hard. It may feel tender and often lumpy. Occasionally, the spleen is enlarged. At first, unless the cancer is blocking the bile ducts, the person has mild or no jaundice (a yellowish discoloration of the skin and the whites of the eyes). If the itself grows or spreads so much that it replaces most of the liver tissue (infiltrative disease), the abdomen may become swollen (distended) with fluid (a condition called ascites). […] In patients with infiltrative disease, in the weeks before death, jaundice progressively worsens. People may become confused and drowsy as toxins accumulate in the brain because the liver is too damaged to remove them from the blood. This condition is called hepatic encephalopathy.

• #21 18 Top Liver Cancer Symptoms & Signs | MD Anderson Cancer Center

  https://www.mdanderson.org/cancer-types/liver-cancer/liver-cancer-symptoms.html

  Itching: Itchy skin can be caused when excess levels of bilirubin reach the skin. […] Pale stools […] Dark urine […] Swollen veins on the abdomen […] Becoming sicker if you have hepatitis or cirrhosis. […] Certain types of liver cancer produce hormones that may cause: […] High blood-calcium levels that may cause constipation, nausea or confusion […] Low blood-sugar levels that may cause tiredness or feeling faint […] Enlarged breasts or shrinking of testicles in men […] High red-blood cell count that may cause redness in the face. […] These symptoms do not always mean you have liver cancer. However, it is important to discuss any symptoms with your doctor since they may signal other health problems.

• #22 HCC symptoms – Liver Cancer UK

  https://livercanceruk.org/liver-cancer-information/types-of-liver-cancer/hcc/signs-and-symptoms/

  Early on, you may have few other symptoms from jaundice. Later, it can cause flu-like symptoms, including fever, aching muscles and feeling weak and tired. You may also feel sick. […] Around 1 in 5 people (20%) have odd symptoms caused by the liver tumours making hormones. Doctors call this paraneoplastic syndrome. One in 10 people (10%) have this when they first go to the doctor. The commonest are: […] high blood calcium, causing sickness, weakness and constipation. If not treated, patients become confused and increasingly drowsy […] low blood sugar causing tiredness, weakness and fainting. […] Sadly, in up to 4 out of 10 people (40%) the cancer has already spread before it’s diagnosed. If it has spread to the bones, you may have bone pain or sudden bone fractures for little or no reason. If it spreads to the lungs, it can cause cough and shortness of breath.

• #23 Liver Cancer Symptoms & Diagnosis | UPMC Hillman Cancer Center

  https://hillman.upmc.com/cancer-care/liver/symptoms-diagnosis

  In the early stages of liver cancer, symptoms aren’t usually acute or intense. When symptoms do occur, they vary from person to person. […] Liver cancer symptoms may include: Fatigue or weakness. Jaundice. Loss of appetite. Hard lump on the right side, below the rib cage. Nausea or vomiting. Pain or swelling in the upper abdomen. Pain around the right shoulder blade. […] Unexplained weight loss. Fever. Jaundice, which causes dark urine and yellow skin and eyes. Feeling of fullness after a small meal. Itching. Swollen veins on the belly. Becoming sicker if you have hepatitis or cirrhosis. […] Certain types of liver cancer also produce hormones that may cause: High blood calcium levels may cause constipation, nausea, or confusion. Low blood sugar levels may cause tiredness or a faint feeling. Enlarged breasts or shrinking of testicles in men. A high red blood cell count may cause redness in the face. […] These symptoms do not mean you have liver cancer. But it’s vital to talk to your doctor about your symptoms to rule out other health problems.

• #24 Signs and Symptoms of Liver Cancer | American Cancer Society

  https://www.cancer.org/cancer/types/liver-cancer/detection-diagnosis-staging/signs-symptoms.html

  People who have chronic hepatitis or cirrhosis might feel worse than usual or just have changes on lab test results, such as liver function tests or alpha-fetoprotein (AFP) levels. […] Having one or more of the signs or symptoms above does not mean you have liver cancer. In fact, many of these signs and symptoms are more likely to be caused by other conditions. Still, if you have any of them, its important to have them checked by a doctor so that the cause can be found and treated, if needed.

• #25 Stages of liver cancer | Canadian Cancer Society

  https://cancer.ca/en/cancer-information/cancer-types/liver/staging

  There is 1 tumour that is 2 cm or smaller. It isnt causing any symptoms. The tumour has not grown into the large blood vessels in the liver. […] There are up to 3 tumours. All of the tumours are smaller than 3 cm. They arent causing any symptoms. The tumours have not grown into the large blood vessels in the liver. […] There are more than 3 tumours in the liver or 1 to 3 tumours with at least 1 that is larger than 3 cm. They arent causing any symptoms. The tumours have not grown into the large blood vessels in the liver. […] The cancer has grown into the large blood vessels in the liver or it has spread outside the liver to other parts of the body. It is causing symptoms. […] The cancer may have grown into the large blood vessels or spread to other parts of the body. It is causing symptoms.

• #26 Stage 1 liver cancer | Cancer Research UK

  https://www.cancerresearchuk.org/about-cancer/liver-cancer/stages/stage-1

  Stage 1 liver cancer has not spread to the lymph nodes or anywhere else in the body. […] Stage 1A means there is a single tumour in the liver that is 2cm or less, and it has not grown into the blood vessels. […] Stage 1B means there is a single tumour that is more than 2cm, and it has not grown into the blood vessels. […] The stage of your cancer helps your doctor to decide which treatment you need. […] The treatments for stage 1 include: […] You might have an operation to remove part of your liver (liver resection). […] Your doctor may recommend a liver transplant if you have scarring of the liver (cirrhosis) and you are well enough. […] Embolisation is a treatment that blocks or reduces the blood supply to the cancer. […] You usually have this treatment if you can’t have surgery, or to help control the cancer while you are waiting for a liver transplant. […] These treatments use heat or radiation to destroy cancer cells. […] This treatment uses alcohol to destroy cancer cells.

• #27 Stage 2 Liver Cancer, Symptoms, Staging and Treatments

  https://drpraveenkammar.com/blogs/second-stage-liver-cancer/

  Stage 2 liver cancer is a serious condition, but it is treatable. It is defined as a single tumor that is more than 2 cm in size or multiple tumors that are all less than 5 cm in size. […] The tumor has not spread to the lymph nodes or other areas of the body. […] The second stage, or stage 2 liver cancer, shows a single tumour over 2 cm, and it has grown into blood vessels of the liver. […] Stage 2 liver cancer symptoms include: Persistent pain in the lower right side of the belly, Feeling of fullness, Loss of appetite, Nausea or vomiting, Unexplained weight loss, Swelling in the belly, Fever, Abnormal bleeding or bruising, Yellowish discolouration of skin and eyes. […] If you experience any symptoms and are concerned about your risk of liver cancer, you must visit a Liver Cancer Specialist in Mumbai Dr. Praveen Kammar about liver cancer screening.

• #28 Liver Cancer: Symptoms, Signs, Causes & Treatment

  https://my.clevelandclinic.org/health/diseases/9418-liver-cancer

  Further, researchers break down survival rates by cancer stage. The five-year survival rate for early-stage (stage I or stage II) liver cancer is 37%. That survival rate drops to 13% for stage III liver cancer and 3% for stage IV liver cancer. […] Primary liver cancer is a life-threatening illness. You may not know you have liver cancer until it’s in an advanced stage. That limits your treatment options. Your healthcare team will do treatments to keep cancer from growing. They’ll also offer treatments to ease your symptoms and maintain your quality of life. Ask your doctor to explain advanced cancer treatment options. They’ll explain the benefits and side effects of each option. That way, you can feel more confident about your choices going forward.

• #29 Understanding Stage 3 Liver Cancer and Life Expectancy – Mandaya Hospital Group

  https://mandayahospitalgroup.com/stage-3-liver-cancer/

  Stage 3 liver cancer occurs when cancerous cells grow significantly, typically exceeding 5 cm in size, and begin to spread to surrounding organs, though they have not yet reached the lymph nodes. The treatment for stage 3 liver cancer generally aims to prevent further tumor growth and manage symptoms. […] Symptoms of stage 3 liver cancer may include: Abdominal pain, Pain near the right shoulder blade or upper abdomen, Loss of appetite, weight loss, or nausea, Abdominal swelling or bloating, Yellowing of the skin and eyes (jaundice), Persistent fatigue or weakness, Unexplained fever. […] The goal of stage 3 liver cancer treatment is to prolong life expectancy and control symptoms. […] According to Cancer Research UK, only 10% of liver cancer patients survive for four years or more after diagnosis. […] However, this statistic is not absolute. Life expectancy varies based on the patients overall health, response to treatment, and support received.

• #30 Stage 4 Liver Cancer: Treatment and Outlook

  https://www.healthline.com/health/stage-4-liver-cancer

  Stage 4 liver cancer is when cancer spreads from your liver into lymph nodes or to distant organs and tissues. It cant be cured, but treatments may help slow progression and manage symptoms. […] Many liver cancers arent diagnosed until theyve reached a later stage. Stage 4 is the most advanced stage of liver cancer. It happens when liver cancer has spread farther beyond your liver. […] When it has metastasized, liver cancer is more likely to spread to certain areas. These include your lungs, bones, brain, and adrenal glands. […] While stage 4 liver cancer is often terminal, it can still be treated. Treatments for terminal liver cancer are aimed at prolonging your survival, managing your symptoms, and improving your quality of life. […] The outlook for someone with stage 4 liver cancer is generally poor. The SEER database notes that the 5-year relative survival rates for liver cancer that has spread regionally or distantly are 14.3% and 3.5%, respectively. […] Stage 4 liver cancer cant be cured. Instead, treatment aims to slow the cancers progression, prolong your survival, manage your symptoms, and improve your quality of life.

• #31 The Different Stages of Liver Cancer | USA Oncology Centers

  https://www.usaoncologycenters.com/the-different-stages-of-liver-cancer/

  People with liver cancer often experience no symptoms, especially when the tumor is detected early through a screening program. However, when symptoms or signs of liver cancer do occur, they may include the following: […] Many of the signs and symptoms above may be caused by conditions other than liver cancer. However, if you notice any of these symptoms, it is important to consult with your doctor for an accurate diagnosis. […] Stage C (advanced stage): The cancer has spread into the blood vessels, lymph nodes, or other distant organs. Patients do not feel well and are less active, but their liver is still functioning relatively normally. […] Stage D (terminal stage): Patients have severe liver damage, are not feeling well, and need help to look after themselves. This stage carries the worst prognosis and only supportive measures are recommended.

• #32 Liver Cancer: Symptoms & Prevention | Franciscan Health

  https://www.franciscanhealth.org/community/blog/liver-cancer-symptoms-prevention

  Symptoms of liver cancer can often seem like signs of other conditions. These signs may include: […] Jaundice (yellowing of your skin or eyes) […] Discomfort in the upper right abdomen […] A hard lump on the right side below the rib cage […] A swollen abdomen […] Pain near the right shoulder blade or in the back […] Easy bruising or bleeding […] Unexplained tiredness […] Unexplained nausea, vomiting, loss of appetite or weight loss. […] Up to 60% of liver cancers are only diagnosed in advanced stages, resulting in a survival rate of just 20%.

• #33 Hepatocellular Carcinoma (HCC): Symptoms & Treatment

  https://my.clevelandclinic.org/health/diseases/21709-hepatocellular-carcinoma-hcc

  Many conditions cause similar symptoms, and most arent as serious as hepatocellular cancer. So, try not to panic if you experience one or more of them. But if symptoms last longer than two weeks, its best to see a healthcare provider. […] Most people diagnosed with HCC have cirrhosis of the liver (approximately 80%) although some have a a condition that can lead to cirrhosis of the liver. In some instances, the condition never progresses to cirrhosis, but people still develop HCC. […] With these conditions, unmanaged long-term liver inflammation can lead to severe scarring and, eventually, HCC. […] Surgery to remove the tumor or a liver transplant are the best options for a cure. If surgery isnt an option, there are other treatments to ease your symptoms, slow the tumors growth and help you live longer.

• #34 Hepatocellular Carcinoma: Risks, Symptoms & Treatments

  https://liverfoundation.org/liver-diseases/cancer/hepatocellular-carcinoma/

  Long-term (chronic) hepatitis B and hepatitis C infections are linked to hepatocellular carcinoma or liver cancer because they often lead to cirrhosis if they are undiagnosed and/or untreated. […] People with fatty liver may over time develop complications including cirrhosis, thereby putting them at risk for hepatocellular carcinoma or liver cancer. […] Remember people with cirrhosis should speak to their doctors about recommendations for regular surveillance and screenings for liver cancer. This can help detect cancer before symptoms start and the cancer becomes advanced.

• #34 Hepatocellular Carcinoma: Risks, Symptoms & Treatments

  https://liverfoundation.org/liver-diseases/cancer/hepatocellular-carcinoma/

  Know the risks and understand the symptoms of Hepatocellular Carcinoma. […] People may not feel ill in the earliest stages of liver cancer, which is why it is very important to understand your risks and to talk to your doctor about liver cancer before you experience symptoms. […] Once symptoms occur, they can include: Fatigue, Bloating or feelings of fullness, Pain on the right side of the upper abdomen or back and shoulder, Nausea, Loss of appetite, Weight loss, Weakness, Fever, Jaundice (yellowing of the skin and the whites of the eyes). […] Liver disease is a progression that follows stages of illness. Some people with liver disease progress to cirrhosis (scarring) of the liver, which puts them at increased risk for liver cancer. […] Having cirrhosis is a risk factor for developing hepatocellular carcinoma (primary liver cancer).

• #35 Liver Cancer Symptoms, Prognosis, Treatment, Causes, Screening

  https://www.medicinenet.com/liver_cancer_hepatocellular_carcinoma/article.htm

  The survival rate can also be affected by the available treatments. Liver cancers that can be surgically removed have an improved survival rate. When caught in the earliest stages, and the liver is transplanted, the 5-year survival rate can be as high as 70%. […] Primary liver cancer deaths are usually from liver failure, bleeding, or advanced cancer. […] Liver cancer is difficult to cure, as it is most often not caught in the early stage. When successfully treated, Liver cancer may never go away completely, so follow-up is very important.

• #36 Symptoms of liver cancer – NHS

  https://www.nhs.uk/conditions/liver-cancer/symptoms/

  symptoms of indigestion, such as feeling full very quickly when eating. […] a very swollen tummy that is not related to when you eat. […] See a GP if you have: a lump in your tummy. […] lost a lot of weight without trying. […] symptoms of liver cancer that get worse or do not get better after 2 weeks.

• #37 Symptoms of liver cancer – weight loss, nausea, tiredness | Macmillan Cancer Support

  https://www.macmillan.org.uk/cancer-information-and-support/liver-cancer/signs-and-symptoms-of-liver-cancer

  In the early stages of primary liver cancer, there are often no symptoms. […] In the early stages of liver cancer (also called Hepatocellular carcinoma or HCC), there are often no symptoms. […] Possible symptoms of liver cancer include: loss of appetite and feeling full soon after starting to eat, weight loss, feeling sick (nausea) and being sick (vomiting), tiredness (fatigue), aching or pain on the right side of the tummy (abdomen) near the ribs, and sometimes in the right shoulder, a high temperature and flu-like symptoms, such as aching all over, a swollen tummy, which may be caused by fluid build-up (ascites), the skin and whites of the eyes looking yellow (jaundice), bruising or bleeding easily. […] These symptoms can be caused by other conditions. But it is important to get them checked by your doctor or nurse. It is especially important to get them checked if you have risk factors for liver cancer.

• #38 Hepatocellular Carcinoma (HCC): Symptoms & Treatment

  https://my.clevelandclinic.org/health/diseases/21709-hepatocellular-carcinoma-hcc

  Researchers continue to search for new ways to cure hepatocellular carcinoma that cant be removed with surgery. In the meantime, new treatments, like immunotherapy and targeted therapy, continue to improve the life expectancy of people diagnosed with advanced HCC. […] The five-year relative survival rate (people alive five years after their diagnosis) for people with HCC is 21%. […] Catching HCC early, when surgery can treat it, delivers the best possible outcomes.

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