Materiały źródłowe

• #1 Treatment of Breast Cancer in Men, by Stage | American Cancer Society

  https://www.cancer.org/cancer/types/breast-cancer-in-men/treating/by-stage.html

  This information is based on AJCC Staging systems prior to 2018 which were primarily based on tumor size and lymph node status. […] Because there have been few clinical trials on treatment of male breast cancer, most doctors base their treatment recommendations on their experience with the disease and on the results of studies of breast cancer in women. With some minor variations, breast cancer in men is treated the same way as breast cancer in women. […] The stage (extent) of your breast cancer is an important factor in making decisions about your treatment options. In general, the more the breast cancer has spread, the more treatment you will likely need. […] It is treated with surgery to remove the cancer. Most often in males, a mastectomy is done. If breast-conserving surgery is done, it is followed by radiation therapy to the remaining breast tissue.

• #2 Male Breast Cancer Treatment (PDQ®) – NCI

  https://www.cancer.gov/types/breast/hp/male-breast-treatment-pdq

  Treatment options for men with breast cancer are described in Table 1. […] The approach to the treatment of men with breast cancer is similar to that for women. […] As in women, treatment options for men with early-stage breast cancer include: Surgery with or without radiation therapy (locoregional therapy). […] Adjuvant therapy (systemic therapy). […] Primary treatment is a mastectomy with axillary lymph node dissection. […] Responses in men are generally similar to those seen in women with breast cancer. […] The optimal systemic treatment in men with breast cancer has not been studied in randomized clinical trials. […] Adjuvant therapy should be administered according to the same criteria used for women. […] Treatment options for men with locally advanced breast cancer include: Neoadjuvant chemotherapy.

• #3 Male Breast Cancer Treatment – NCI

  https://www.cancer.gov/types/breast/patient/male-breast-treatment-pdq

  Male breast cancer is a disease in which malignant (cancer) cells form in the tissues of the breast. […] The treatment of male breast cancer depends partly on the stage of the disease. […] Five types of standard treatment are used to treat men with breast cancer: Surgery, Chemotherapy, Hormone therapy, Radiation therapy, Targeted therapy. […] Treatment for male breast cancer may cause side effects. […] Surgery for men with breast cancer is usually a modified radical mastectomy, surgery to remove the whole breast that has cancer. […] Hormone therapy is a cancer treatment that removes hormones or blocks their action and stops cancer cells from growing. […] Hormone therapy with tamoxifen is often given to patients with estrogen-receptor and progesterone-receptor positive breast cancer and to patients with metastatic breast cancer (cancer that has spread to other parts of the body).

• #4 Male Breast Cancer: Symptoms, Causes & Treatment

  https://my.clevelandclinic.org/health/diseases/9011-male-breast-cancer

  Male breast cancer develops in breast tissue. Treatment includes surgery, chemotherapy, radiation, hormone therapy and targeted therapy. […] Your treatment depends on the cancer type and stage. You’ll likely need a combination of treatments that follow a timeline that your provider will explain to you. […] Breast cancer surgery is the most common treatment for early-stage male breast cancer. Surgery to remove your entire breast (mastectomy) is more common than surgery to remove the lump only (lumpectomy). […] Radiation for breast cancer uses X-rays or other energy sources to kill cancer cells. […] Chemotherapy uses drugs to kill cancer cells throughout your body. […] Providers use hormone therapy to lower estrogen levels or block their effects. […] Targeted therapy treatments interfere with processes that allow cancer cells to grow.

• #5 Treatment for breast cancer in men – NHS

  https://www.nhs.uk/conditions/breast-cancer-in-men/treatment-for-breast-cancer-in-men/

  The main treatment for breast cancer is usually surgery. You may also have chemotherapy, radiotherapy, treatment with hormones (hormone therapy), and targeted medicines. […] Surgery is usually the main treatment for breast cancer. […] You may have radiotherapy for breast cancer: after surgery to lower the chance of the cancer coming back, if you have secondary breast cancer. […] You may have chemotherapy for breast cancer: before surgery to help make the cancer smaller, after surgery to lower the chance of the cancer coming back, if you have secondary breast cancer. […] Hormone therapy may be used: before surgery to help make the cancer smaller, after surgery to lower the chance of the cancer coming back, if you have secondary breast cancer. […] Targeted medicines may be used: to lower the chance of the cancer coming back, if you have secondary breast cancer. […] The aim of treatment will be to slow down the spread of the cancer, to help with the symptoms, help you feel better and help you live longer.

• #6 Treatment for breast cancer in men | Breast Cancer Now

  https://breastcancernow.org/about-breast-cancer/treatment/treatment-for-breast-cancer-in-men

  Learn about treatment for breast cancer in men, including chemotherapy, radiotherapy and hormone therapy, and understand the possible side effects. […] Treatment for breast cancer in men may include: Surgery, Chemotherapy, Radiotherapy, Hormone (endocrine) therapy, Targeted therapy. […] If the cancer has not spread beyond the breast tissue or the lymph nodes under the arm (primary breast cancer), treatment aims to remove the cancer and reduce the risk of it coming back or spreading to other parts of the body. […] If the cancer has spread to another part of the body, known as secondary breast cancer, treatment can be given to control and slow the spread of the cancer, relieve symptoms and give you the best quality of life for as long as possible. […] Surgery to remove the cancer is the first treatment for most men.

• #7 Male Breast Cancer Treatment – NCI

  https://www.cancer.gov/types/breast/patient/male-breast-treatment-pdq

  Male breast cancer is a disease in which malignant (cancer) cells form in the tissues of the breast. […] The treatment of male breast cancer depends partly on the stage of the disease. […] Five types of standard treatment are used to treat men with breast cancer: Surgery, Chemotherapy, Hormone therapy, Radiation therapy, Targeted therapy. […] Treatment for male breast cancer may cause side effects. […] Surgery for men with breast cancer is usually a modified radical mastectomy, surgery to remove the whole breast that has cancer. […] Hormone therapy is a cancer treatment that removes hormones or blocks their action and stops cancer cells from growing. […] Hormone therapy with tamoxifen is often given to patients with estrogen-receptor and progesterone-receptor positive breast cancer and to patients with metastatic breast cancer (cancer that has spread to other parts of the body).

• #8 Male breast cancer – Diagnosis and treatment – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/male-breast-cancer/diagnosis-treatment/drc-20374745

  Male breast cancer treatment usually starts with surgery. Other common treatments include chemotherapy, hormone therapy and radiation therapy. To create a treatment plan, your health care team looks at your cancer’s stage, your overall health and what you prefer. […] The goal of surgery is to remove the cancer and some of the healthy tissue around it. Operations used to treat male breast cancer include: […] A mastectomy involves removing all the breast tissue from one side of your chest. This includes removing the nipple and the skin around it, called the areola. This is the most common type of surgery for male breast cancer. […] A lumpectomy involves removing the cancer and some of the healthy tissue around it. The rest of the breast tissue isn’t removed. Sometimes doctors call this breast-conserving surgery. Often, radiation therapy is recommended after lumpectomy.

• #9 Male Breast Cancer Treatment (PDQ®) – PDQ Cancer Information Summaries – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK65980/

  Male breast cancer is a disease in which malignant (cancer) cells form in the tissues of the breast. […] This PDQ cancer information summary has current information about the treatment of male breast cancer. […] The treatment of male breast cancer depends partly on the stage of the disease. […] There are different types of treatment for men with breast cancer. […] Five types of standard treatment are used to treat men with breast cancer: Surgery, Chemotherapy, Hormone therapy, Radiation therapy, Targeted therapy. […] Treatment for male breast cancer may cause side effects. […] Surgery for men with breast cancer is usually a modified radical mastectomy, surgery to remove the whole breast that has cancer. […] Hormone therapy with tamoxifen is often given to patients with estrogen-receptor and progesterone-receptor positive breast cancer and to patients with metastatic breast cancer.

• #10 Breast cancer in men | Causes, Symptoms & Treatments | Cancer Council

  https://www.cancer.org.au/cancer-information/types-of-cancer/breast-cancer-in-men

  Treatment for breast cancer in men depends on the extent of the cancer. […] The main treatment for breast cancer in men is surgical removal of the breast (mastectomy). The whole breast is removed, including the nipple. Usually the pectoralis muscles under the breast do not need to be removed. Partial mastectomy is usually not a suitable option for men. […] Radiation therapy is sometimes recommended after surgery with the aim of eradicating any cancer cells that may remain. […] Chemotherapy uses drugs to kill cancer cells or slow their growth. It may be recommended after surgery, especially if cancer is seen in the lymph nodes. […] Hormone therapy may be used in addition to other treatments. Hormone therapy aims to block the effect of oestrogen or reduce the amount of oestrogen in the body. They are effective treatment for breast cancer that has oestrogen (ER) receptors. These are taken as tablets, usually for a five or ten year course.

• #11 Treatment of Breast Cancer in Men, by Stage | American Cancer Society

  https://www.cancer.org/cancer/types/breast-cancer-in-men/treating/by-stage.html

  The main treatment for stage I breast cancer is to remove it with surgery. This is usually done by mastectomy, but breast-conserving surgery (BCS) might occasionally be an option. If breast-conserving surgery is done, it is usually followed by radiation therapy. […] Hormone therapy, chemotherapy (chemo) and/or targeted therapy may be recommended as adjuvant (after surgery) therapy, based on the tumor size and results of lab tests. Hormone therapy with tamoxifen is usually recommended for hormone receptor-positive tumors. […] Systemic (drug) therapy is often recommended for men with stage II breast cancer. […] Radiation therapy may be given after surgery if the tumor is large or if it is found to have spread to several lymph nodes. […] Most often, these cancers are treated with chemo before surgery (neoadjuvant chemo).

• #12 Male breast cancer – Diagnosis and treatment – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/male-breast-cancer/diagnosis-treatment/drc-20374745

  Male breast cancer treatment usually starts with surgery. Other common treatments include chemotherapy, hormone therapy and radiation therapy. To create a treatment plan, your health care team looks at your cancer’s stage, your overall health and what you prefer. […] The goal of surgery is to remove the cancer and some of the healthy tissue around it. Operations used to treat male breast cancer include: […] A mastectomy involves removing all the breast tissue from one side of your chest. This includes removing the nipple and the skin around it, called the areola. This is the most common type of surgery for male breast cancer. […] A lumpectomy involves removing the cancer and some of the healthy tissue around it. The rest of the breast tissue isn’t removed. Sometimes doctors call this breast-conserving surgery. Often, radiation therapy is recommended after lumpectomy.

• #13 Male Breast Cancer Treatment

  https://www.komen.org/breast-cancer/treatment/by-diagnosis/male-breast-cancer/

  Breast cancer can occur in men. This may be called male breast cancer. […] Treatment for breast cancer in men is similar to treatment for women. Treatment for early and locally advanced breast cancers includes some combination of: Surgery, Radiation therapy, Chemotherapy, Hormone therapy, HER2-targeted therapy, CDK4/6 inhibitor therapy, Immunotherapy, PARP inhibitor therapy. […] Breast cancer surgery in men is usually a mastectomy because of the small size of the male breast. Some men may choose to have breast reconstruction. Some men who have a mastectomy may also have radiation therapy after surgery, depending on the stage of the breast cancer. […] For men with hormone receptor-positive breast cancers, the hormone therapy drug tamoxifen, with or without the CDK4/6 inhibitor abemaciclib (Verzenio), is usually the first drug therapy used. Tamoxifen is a pill taken every day for 5-10 years.

• #14 Male Breast Cancer Treatment – NCI

  https://www.cancer.gov/types/breast/patient/male-breast-treatment-pdq

  Radiation therapy is a cancer treatment that uses high-energy x-rays or other types of radiation to kill cancer cells or keep them from growing. […] Targeted therapy is a type of treatment that uses drugs or other substances to identify and attack specific cancer cells. […] The treatment options for metastatic breast cancer (cancer that has spread to distant parts of the body) may include hormone therapy, targeted therapy, chemotherapy, surgery, and radiation therapy.

• #15 Radiation Therapy for Male Breast Cancer | NYU Langone Health

  https://nyulangone.org/conditions/male-breast-cancer/treatments/radiation-therapy-for-male-breast-cancer

  Radiation therapy is used after a lumpectomy to destroy any remaining cancer cells and to prevent breast cancer from returning. […] Doctors may also recommend radiation therapy after a mastectomy if cancer is found in the lymph nodes small glands that make and store lymphocytes, white blood cells that help fight infection located under the arm. […] NYU Langone doctors use external beam radiation therapy to manage breast cancer in men. During this therapy, a machine called a linear accelerator rotates around you, delivering beams of different strengths that are customized to the size and shape of the tumor. Treatment sessions usually occur once a day, five days a week, and take several weeks to complete. […] After a lumpectomy, radiation therapy is delivered to the entire breast. In addition, the area where the tumor was located may receive an additional dose called a radiation boost.

• #16 Male breast cancer – Diagnosis and treatment – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/male-breast-cancer/diagnosis-treatment/drc-20374745

  Radiation therapy uses powerful energy beams to kill cancer cells. The energy can come from X-rays, protons or other sources. During radiation therapy, you lie on a table while a machine moves around you. The machine directs radiation to precise points on your body. […] In male breast cancer, radiation therapy may be used after surgery to kill any cancer cells that might be left behind. The radiation is often aimed at the chest and armpit. […] Most male breast cancers have cells that rely on hormones to grow, called hormone sensitive. If your cancer is hormone sensitive, hormone therapy might be an option. Hormone therapy can keep cancer from coming back after surgery. If the cancer spreads to other parts of the body, hormone therapy may help slow its growth. […] Chemotherapy uses strong medicines to kill cancer cells. These medicines are often given through a vein. Some chemotherapy medicines are available in pill form.

• #17 Radiation Therapy for Male Breast Cancer | NYU Langone Health

  https://nyulangone.org/conditions/male-breast-cancer/treatments/radiation-therapy-for-male-breast-cancer

  Radiation therapy is used after a lumpectomy to destroy any remaining cancer cells and to prevent breast cancer from returning. […] Doctors may also recommend radiation therapy after a mastectomy if cancer is found in the lymph nodes small glands that make and store lymphocytes, white blood cells that help fight infection located under the arm. […] NYU Langone doctors use external beam radiation therapy to manage breast cancer in men. During this therapy, a machine called a linear accelerator rotates around you, delivering beams of different strengths that are customized to the size and shape of the tumor. Treatment sessions usually occur once a day, five days a week, and take several weeks to complete. […] After a lumpectomy, radiation therapy is delivered to the entire breast. In addition, the area where the tumor was located may receive an additional dose called a radiation boost.

• #18 Male breast cancer – Diagnosis and treatment – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/male-breast-cancer/diagnosis-treatment/drc-20374745

  Radiation therapy uses powerful energy beams to kill cancer cells. The energy can come from X-rays, protons or other sources. During radiation therapy, you lie on a table while a machine moves around you. The machine directs radiation to precise points on your body. […] In male breast cancer, radiation therapy may be used after surgery to kill any cancer cells that might be left behind. The radiation is often aimed at the chest and armpit. […] Most male breast cancers have cells that rely on hormones to grow, called hormone sensitive. If your cancer is hormone sensitive, hormone therapy might be an option. Hormone therapy can keep cancer from coming back after surgery. If the cancer spreads to other parts of the body, hormone therapy may help slow its growth. […] Chemotherapy uses strong medicines to kill cancer cells. These medicines are often given through a vein. Some chemotherapy medicines are available in pill form.

• #19 Radiation Therapy for Male Breast Cancer | NYU Langone Health

  https://nyulangone.org/conditions/male-breast-cancer/treatments/radiation-therapy-for-male-breast-cancer

  After a mastectomy, radiation therapy is delivered to the chest wall, which is the muscle behind the removed breast tissue, and the draining lymph node basins, which are the areas where axillary lymph nodes were removed. […] NYU Langone doctors are able to avoid serious side effects of radiation therapy, such as heart or lung damage, with these highly targeted treatments. Men who have radiation therapy may experience breast swelling and skin irritation similar to a sunburn. Doctors can prescribe topical skin creams to help manage these side effects. They also can recommend our support services and NYU Langone’s integrative health services.

• #20 Hormone Therapy for Breast Cancer in Men | American Cancer Society

  https://www.cancer.org/cancer/types/breast-cancer-in-men/treating/hormone-therapy.html

  Hormone therapy (sometimes called endocrine therapy) is a way to treat cancer by using hormones or drugs or other treatments that affect hormones. Hormone therapy is a form of systemic therapy, meaning it can reach nearly all parts of the body. […] Hormone therapy can be used after surgery (adjuvant therapy) to help lower the risk of cancer coming back, or before surgery (neoadjuvant treatment). It can also be used to treat cancer that has spread, or cancer that has come back after treatment (recurred). […] About 9 of 10 breast cancers in men are hormone receptor-positive, meaning they are estrogen receptor (ER)-positive, progesterone receptor (PR)-positive, or both. This makes them more likely to respond to hormone treatments. Hormone therapy does not help people whose tumors are both ER- and PR-negative.

• #21 Male Breast Cancer Treatment – NCI

  https://www.cancer.gov/types/breast/patient/male-breast-treatment-pdq

  Male breast cancer is a disease in which malignant (cancer) cells form in the tissues of the breast. […] The treatment of male breast cancer depends partly on the stage of the disease. […] Five types of standard treatment are used to treat men with breast cancer: Surgery, Chemotherapy, Hormone therapy, Radiation therapy, Targeted therapy. […] Treatment for male breast cancer may cause side effects. […] Surgery for men with breast cancer is usually a modified radical mastectomy, surgery to remove the whole breast that has cancer. […] Hormone therapy is a cancer treatment that removes hormones or blocks their action and stops cancer cells from growing. […] Hormone therapy with tamoxifen is often given to patients with estrogen-receptor and progesterone-receptor positive breast cancer and to patients with metastatic breast cancer (cancer that has spread to other parts of the body).

• #22 Hormone Therapy for Breast Cancer in Men | American Cancer Society

  https://www.cancer.org/cancer/types/breast-cancer-in-men/treating/hormone-therapy.html

  Hormone therapy (sometimes called endocrine therapy) is a way to treat cancer by using hormones or drugs or other treatments that affect hormones. Hormone therapy is a form of systemic therapy, meaning it can reach nearly all parts of the body. […] Hormone therapy can be used after surgery (adjuvant therapy) to help lower the risk of cancer coming back, or before surgery (neoadjuvant treatment). It can also be used to treat cancer that has spread, or cancer that has come back after treatment (recurred). […] About 9 of 10 breast cancers in men are hormone receptor-positive, meaning they are estrogen receptor (ER)-positive, progesterone receptor (PR)-positive, or both. This makes them more likely to respond to hormone treatments. Hormone therapy does not help people whose tumors are both ER- and PR-negative.

• #23 Hormonal therapy for breast cancer in men explained | Macmillan Cancer Support

  https://www.macmillan.org.uk/cancer-information-and-support/treatments-and-drugs/hormonal-therapy-for-breast-cancer-in-men

  Hormonal therapy is one of the main treatments for breast cancer in men. […] Hormonal therapy reduces the amount of oestrogen in the body or stops oestrogen attaching to cancer cells. It only works for breast cancer that is oestrogen receptor positive (ER positive). […] Your cancer doctor will advise you to have hormonal therapy to reduce the risk of breast cancer coming back. It also helps reduce the risk of getting a new breast cancer in your other breast. […] You usually have hormonal therapy drugs for a number of years. This may be for up to 10 years. You usually start taking them after surgery or chemotherapy. […] Hormonal therapy is also used if breast cancer comes back in the same area or spreads to another part of the body (secondary breast cancer). […] Tamoxifen is an anti-oestrogen drug. It stops oestrogen attaching to breast cancer cells and making them grow. This is the most common type of hormonal therapy used for breast cancer in men.

• #24 Hormone Therapy for Breast Cancer in Men | American Cancer Society

  https://www.cancer.org/cancer/types/breast-cancer-in-men/treating/hormone-therapy.html

  Tamoxifen is the best studied hormone drug for breast cancer in men and is most often used first. If tamoxifen doesn’t work (or stops working), other hormone drugs may be tried, but this is largely based on how well they work in women with breast cancer. […] Large studies of women with early-stage, hormone receptor-positive cancers have shown that taking tamoxifen after surgery for 5 years reduces the chances of the cancer coming back by about half. Taking it for 10 years may help even more. Studies in men with breast cancer have been smaller, but they have also found that taking tamoxifen after surgery for early-stage breast cancer can lower the chance of the cancer coming back and improve survival. […] Tamoxifen can also be used to treat metastatic breast cancer. […] Orchiectomy shrinks most male breast cancers, and it may help make other treatments like tamoxifen more likely to work. […] Although some of these drugs have unique side effects, in general they can cause loss of sexual desire, trouble getting erections, weight gain, hot flashes, and mood swings. Be sure to discuss any such side effects with your cancer care team because there may be ways to treat them.

• #25 Survival benefit of tamoxifen in male breast cancer: prospective cohort analysis | British Journal of Cancer

  https://www.nature.com/articles/s41416-020-0857-z

  Due to the lack of prospective data, current treatment of male breast cancer (MBC) is based on information obtained from retrospective analysis or by extrapolation from studies on female patients. […] Notably, DFS among men who did not receive tamoxifen was significantly reduced as compared with those who underwent tamoxifen therapy (P=0.002). […] Tamoxifen treatment was associated with improved DFS for MBC patients. […] Our prospective cohort study showed that tamoxifen treatment improved DFS of patients with MBC. […] Tamoxifen treatment significantly reduces the recurrence rate in our cohort.

• #26 Hormonal therapy for breast cancer in men explained | Macmillan Cancer Support

  https://www.macmillan.org.uk/cancer-information-and-support/treatments-and-drugs/hormonal-therapy-for-breast-cancer-in-men

  Aromatase inhibitors (AIs) also reduce oestrogen levels. These drugs reduce oestrogen levels in men by stopping male hormones (androgens) being made into oestrogen. […] Your cancer doctor may prescribe an AI such as anastrozole, letrozole or exemestane. […] Goserelin blocks these signals and stops the testicles making the hormones. […] Hormonal therapy reduces the risk of breast cancer coming back. […] Most people cope well with the side effects of hormonal therapy. […] If the side effects do not improve or are difficult to cope with, talk to your breast cancer nurse or cancer doctor. […] Different hormonal therapy drugs have different side effects. Some of the main side effects include: hot flushes and sweats, weight gain, joint and muscle pain, tiredness, sexual effects, including erection problems. […] Some types of hormonal therapy can slightly increase the risk of developing a blood clot.

• #27 Men With Breast Cancer Need More Treatment Options and Access to Genetic Counseling | FDA

  https://www.fda.gov/consumers/consumer-updates/men-breast-cancer-need-more-treatment-options-and-access-genetic-counseling

  When used in men, aromatase inhibitors are often given in combination with another drug luteinizing hormone-releasing hormone agonist (LHRH) to adequately suppress estrogen levels. […] For men with larger tumors or tumors that have spread outside of the breast, chemotherapy is often recommended in addition to hormone treatment, just as it is for women. […] All men with breast cancer should be referred for genetic counseling, Prowell advises. […] People should tell their health care provider if any man in their family has had breast cancer, Prowell says.

• #28 Hormonal therapy for breast cancer in men explained | Macmillan Cancer Support

  https://www.macmillan.org.uk/cancer-information-and-support/treatments-and-drugs/hormonal-therapy-for-breast-cancer-in-men

  Aromatase inhibitors (AIs) also reduce oestrogen levels. These drugs reduce oestrogen levels in men by stopping male hormones (androgens) being made into oestrogen. […] Your cancer doctor may prescribe an AI such as anastrozole, letrozole or exemestane. […] Goserelin blocks these signals and stops the testicles making the hormones. […] Hormonal therapy reduces the risk of breast cancer coming back. […] Most people cope well with the side effects of hormonal therapy. […] If the side effects do not improve or are difficult to cope with, talk to your breast cancer nurse or cancer doctor. […] Different hormonal therapy drugs have different side effects. Some of the main side effects include: hot flushes and sweats, weight gain, joint and muscle pain, tiredness, sexual effects, including erection problems. […] Some types of hormonal therapy can slightly increase the risk of developing a blood clot.

• #29 Hormone Therapy for Breast Cancer in Men | American Cancer Society

  https://www.cancer.org/cancer/types/breast-cancer-in-men/treating/hormone-therapy.html

  Tamoxifen is the best studied hormone drug for breast cancer in men and is most often used first. If tamoxifen doesn’t work (or stops working), other hormone drugs may be tried, but this is largely based on how well they work in women with breast cancer. […] Large studies of women with early-stage, hormone receptor-positive cancers have shown that taking tamoxifen after surgery for 5 years reduces the chances of the cancer coming back by about half. Taking it for 10 years may help even more. Studies in men with breast cancer have been smaller, but they have also found that taking tamoxifen after surgery for early-stage breast cancer can lower the chance of the cancer coming back and improve survival. […] Tamoxifen can also be used to treat metastatic breast cancer. […] Orchiectomy shrinks most male breast cancers, and it may help make other treatments like tamoxifen more likely to work. […] Although some of these drugs have unique side effects, in general they can cause loss of sexual desire, trouble getting erections, weight gain, hot flashes, and mood swings. Be sure to discuss any such side effects with your cancer care team because there may be ways to treat them.

• #30 Hormone Therapy for Breast Cancer in Men | American Cancer Society

  https://www.cancer.org/cancer/types/breast-cancer-in-men/treating/hormone-therapy.html

  Tamoxifen is the best studied hormone drug for breast cancer in men and is most often used first. If tamoxifen doesn’t work (or stops working), other hormone drugs may be tried, but this is largely based on how well they work in women with breast cancer. […] Large studies of women with early-stage, hormone receptor-positive cancers have shown that taking tamoxifen after surgery for 5 years reduces the chances of the cancer coming back by about half. Taking it for 10 years may help even more. Studies in men with breast cancer have been smaller, but they have also found that taking tamoxifen after surgery for early-stage breast cancer can lower the chance of the cancer coming back and improve survival. […] Tamoxifen can also be used to treat metastatic breast cancer. […] Orchiectomy shrinks most male breast cancers, and it may help make other treatments like tamoxifen more likely to work. […] Although some of these drugs have unique side effects, in general they can cause loss of sexual desire, trouble getting erections, weight gain, hot flashes, and mood swings. Be sure to discuss any such side effects with your cancer care team because there may be ways to treat them.

• #31 Treatment for breast cancer in men | Breast Cancer Now

  https://breastcancernow.org/about-breast-cancer/treatment/treatment-for-breast-cancer-in-men

  Side effects of tamoxifen include: Hot flushes, Problems getting an erection, Other common side effects include: Indigestion, Headaches, Change in mood. […] Targeted therapy is the name given to a group of drugs that block the growth and spread of cancer. […] Breast cancer in men is less likely to be HER2-positive. However, if your cancer is found to be HER2-positive you may be offered drugs such as trastuzumab and pertuzumab. […] People with breast cancer have a higher risk of blood clots such as a DVT (deep vein thrombosis). […] At the end of your hospital-based treatment, you will continue to be monitored. This is called follow-up. […] Most people worry about breast cancer coming back. These worries are normal, and the fear and anxiety usually lessen with time.

• #32 Male breast cancer – Diagnosis and treatment – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/male-breast-cancer/diagnosis-treatment/drc-20374745

  Radiation therapy uses powerful energy beams to kill cancer cells. The energy can come from X-rays, protons or other sources. During radiation therapy, you lie on a table while a machine moves around you. The machine directs radiation to precise points on your body. […] In male breast cancer, radiation therapy may be used after surgery to kill any cancer cells that might be left behind. The radiation is often aimed at the chest and armpit. […] Most male breast cancers have cells that rely on hormones to grow, called hormone sensitive. If your cancer is hormone sensitive, hormone therapy might be an option. Hormone therapy can keep cancer from coming back after surgery. If the cancer spreads to other parts of the body, hormone therapy may help slow its growth. […] Chemotherapy uses strong medicines to kill cancer cells. These medicines are often given through a vein. Some chemotherapy medicines are available in pill form.

• #33 Male breast cancer – Diagnosis and treatment – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/male-breast-cancer/diagnosis-treatment/drc-20374745

  Chemotherapy might be used after surgery to kill any cancer cells that might be left in the body. Chemotherapy also may be an option for treating cancer that spreads to other parts of the body. […] Targeted therapy uses medicines that attack specific chemicals in the cancer cells. By blocking these chemicals, targeted treatments can cause cancer cells to die. Targeted therapy might be used after surgery to kill any cancer cells that might be left in the body. It also might be an option if the cancer spreads to other parts of the body.

• #34 Treatment of Breast Cancer in Men, by Stage | American Cancer Society

  https://www.cancer.org/cancer/types/breast-cancer-in-men/treating/by-stage.html

  The main treatment for stage I breast cancer is to remove it with surgery. This is usually done by mastectomy, but breast-conserving surgery (BCS) might occasionally be an option. If breast-conserving surgery is done, it is usually followed by radiation therapy. […] Hormone therapy, chemotherapy (chemo) and/or targeted therapy may be recommended as adjuvant (after surgery) therapy, based on the tumor size and results of lab tests. Hormone therapy with tamoxifen is usually recommended for hormone receptor-positive tumors. […] Systemic (drug) therapy is often recommended for men with stage II breast cancer. […] Radiation therapy may be given after surgery if the tumor is large or if it is found to have spread to several lymph nodes. […] Most often, these cancers are treated with chemo before surgery (neoadjuvant chemo).

• #35 Treatment for breast cancer in men | Breast Cancer Now

  https://breastcancernow.org/about-breast-cancer/treatment/treatment-for-breast-cancer-in-men

  The amount of breast tissue removed depends on the area affected and the size of the cancer. […] Most men do not have much breast tissue, so a mastectomy is the most common surgery for men with breast cancer. […] Chemotherapy destroys cancer cells by affecting their ability to divide and grow. […] If you have secondary breast cancer, chemotherapy aims to slow down and control the growth of the cancer and to relieve symptoms. […] Side effects of chemotherapy include: Increased risk of infections, Hair loss, Nausea and vomiting, Fatigue. […] Hormone therapies block or stop the effect of oestrogen on breast cancer cells. […] The most common hormone therapy drug used to treat breast cancer in men is tamoxifen. […] Hormone therapy will only be prescribed if your breast cancer is ER-positive.

• #36 Systemic Therapy for Male Breast Cancer | Memorial Sloan Kettering Cancer Center

  https://www.mskcc.org/cancer-care/types/breast-male/treatment/systemic-therapy

  Chemotherapy drugs work by interrupting the cells growth. In treating breast cancer, doctors often use a combination of two or three drugs at one time. […] About nine in ten men with breast cancer have tumors that are estrogen receptor positive (ER positive), which means that the tumors grow in response to estrogen. These men can be treated with tamoxifen, a drug that targets the estrogen receptor and is also common for treatment of female breast cancer. […] Researchers are developing drugs that work by targeting specific molecules involved in breast cancer development. For example, some breast cancer cells overproduce the protein HER2/neu, leading to more-aggressive tumors. Trastuzumab (Herceptin), lapatinib (Tykerb), pertuzumab (Perjeta), and ado-trastuzumab emtansine (Kadcyla) are drugs that target and inactivate the HER2/neu protein. They are usually given in combination with other systemic therapies.

• #37 Treatment for breast cancer in men | Breast Cancer Now

  https://breastcancernow.org/about-breast-cancer/treatment/treatment-for-breast-cancer-in-men

  The amount of breast tissue removed depends on the area affected and the size of the cancer. […] Most men do not have much breast tissue, so a mastectomy is the most common surgery for men with breast cancer. […] Chemotherapy destroys cancer cells by affecting their ability to divide and grow. […] If you have secondary breast cancer, chemotherapy aims to slow down and control the growth of the cancer and to relieve symptoms. […] Side effects of chemotherapy include: Increased risk of infections, Hair loss, Nausea and vomiting, Fatigue. […] Hormone therapies block or stop the effect of oestrogen on breast cancer cells. […] The most common hormone therapy drug used to treat breast cancer in men is tamoxifen. […] Hormone therapy will only be prescribed if your breast cancer is ER-positive.

• #38 Male Breast Cancer Treatment – NCI

  https://www.cancer.gov/types/breast/patient/male-breast-treatment-pdq

  Radiation therapy is a cancer treatment that uses high-energy x-rays or other types of radiation to kill cancer cells or keep them from growing. […] Targeted therapy is a type of treatment that uses drugs or other substances to identify and attack specific cancer cells. […] The treatment options for metastatic breast cancer (cancer that has spread to distant parts of the body) may include hormone therapy, targeted therapy, chemotherapy, surgery, and radiation therapy.

• #39 Male breast cancer – Diagnosis and treatment – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/male-breast-cancer/diagnosis-treatment/drc-20374745

  Chemotherapy might be used after surgery to kill any cancer cells that might be left in the body. Chemotherapy also may be an option for treating cancer that spreads to other parts of the body. […] Targeted therapy uses medicines that attack specific chemicals in the cancer cells. By blocking these chemicals, targeted treatments can cause cancer cells to die. Targeted therapy might be used after surgery to kill any cancer cells that might be left in the body. It also might be an option if the cancer spreads to other parts of the body.

• #40 Male Breast Cancer Treatment

  https://www.komen.org/breast-cancer/treatment/by-diagnosis/male-breast-cancer/

  For men with hormone receptor-negative breast cancer, chemotherapy is usually the first drug therapy used. […] Men who have HER2-positive breast cancers may be treated with HER2-targeted therapy. For example, treatment may include trastuzumab (Herceptin) plus chemotherapy. […] Some men who have a BRCA1 or BRCA2 inherited gene mutation and have HER2-negative breast cancer may get the PARP inhibitor olaparib (Lynparza). […] Although the exact treatment for breast cancer varies from person to person, evidence-based guidelines help make sure high-quality care is given.

• #41 Systemic Therapy for Male Breast Cancer | Memorial Sloan Kettering Cancer Center

  https://www.mskcc.org/cancer-care/types/breast-male/treatment/systemic-therapy

  Chemotherapy drugs work by interrupting the cells growth. In treating breast cancer, doctors often use a combination of two or three drugs at one time. […] About nine in ten men with breast cancer have tumors that are estrogen receptor positive (ER positive), which means that the tumors grow in response to estrogen. These men can be treated with tamoxifen, a drug that targets the estrogen receptor and is also common for treatment of female breast cancer. […] Researchers are developing drugs that work by targeting specific molecules involved in breast cancer development. For example, some breast cancer cells overproduce the protein HER2/neu, leading to more-aggressive tumors. Trastuzumab (Herceptin), lapatinib (Tykerb), pertuzumab (Perjeta), and ado-trastuzumab emtansine (Kadcyla) are drugs that target and inactivate the HER2/neu protein. They are usually given in combination with other systemic therapies.

• #42 Systemic Therapy for Male Breast Cancer | Memorial Sloan Kettering Cancer Center

  https://www.mskcc.org/cancer-care/types/breast-male/treatment/systemic-therapy

  A current focus of breast cancer research is finding other drugs that work by targeting specific molecules involved in breast cancer development, growth, and spread. These drugs include everolimus (Afinitor) and palbociclib (Ibrance), both of which are being evaluated in conjunction with hormonal therapy.

• #43 Shining a Spotlight on Expanding Treatment Options for Male Breast Cancer  – Susan G. Komen®

  https://www.komen.org/blog/spotlight-on-ethan-clinical-trial/

  Breast cancer is often thought of as a disease that primarily affects women, but men also have a small amount of breast tissue, which means they can get breast cancer too. […] With these numbers, new research is emerging, aiming to expand treatment options for male breast cancer. […] Komen grantee Jose Pablo Leone, M.D., believes this is because most of these men receive a mastectomy and tamoxifen a hormone therapy that has remained the standard of care for male breast cancer for three decades. […] In this study, Dr. Leone and his team are comparing the effectiveness of different hormone therapies (also called endocrine therapies) in men with stage 1-3 estrogen receptor-positive (ER+), human epidermal growth factor receptor 2 negative (HER2-) breast cancer, with the hope of finding better treatment options beyond tamoxifen, which is the current standard of care for these patients.

• #44 Male Breast Cancer Treatment

  https://www.komen.org/breast-cancer/treatment/by-diagnosis/male-breast-cancer/

  For men with hormone receptor-negative breast cancer, chemotherapy is usually the first drug therapy used. […] Men who have HER2-positive breast cancers may be treated with HER2-targeted therapy. For example, treatment may include trastuzumab (Herceptin) plus chemotherapy. […] Some men who have a BRCA1 or BRCA2 inherited gene mutation and have HER2-negative breast cancer may get the PARP inhibitor olaparib (Lynparza). […] Although the exact treatment for breast cancer varies from person to person, evidence-based guidelines help make sure high-quality care is given.

• #45 Male Breast Cancer Treatment (PDQ®) – PDQ Cancer Information Summaries – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK65980/

  Hormone therapy with an aromatase inhibitor is given to some men who have metastatic breast cancer. […] Targeted therapy is a type of treatment that uses drugs or other substances to identify and attack specific cancer cells. […] In men with metastatic breast cancer that is hormone receptor positive and has not responded to other treatments, options may include targeted therapy such as trastuzumab, lapatinib, pertuzumab, or mTOR inhibitors. […] In men with metastatic breast cancer that is hormone receptor negative, has not responded to hormone therapy, has spread to other organs or has caused symptoms, treatment may include chemotherapy with one or more drugs. […] Total mastectomy for men with open or painful breast lesions. […] Radiation therapy to the bones, brain, spinal cord, breast, or chest wall to relieve symptoms and improve quality of life.

• #46 Medication for Male Breast Cancer | NYU Langone Health

  https://nyulangone.org/conditions/male-breast-cancer/treatments/medication-for-male-breast-cancer

  If you have triple negative breast cancer meaning the tumor is estrogen-receptor negative, progesterone-receptor negative, and HER2 negative NYU Langone doctors may prescribe chemotherapy, a group of drugs that destroy cancer cells throughout the body. […] Breast cancer medications have many side effects. Chemotherapy can cause nausea, diarrhea, mouth sores, and fatigue. Hormone therapies can cause hot flashes and night sweats. Some targeted drugs can result in nausea, fatigue, fever, and skin rash. […] Men with breast cancer are encouraged to enroll in a clinical trial at NYU Langone, in which promising new therapies are studied. Men with estrogen-receptor positive breast cancer that has spread throughout the body may be eligible for a study of a targeted drug that blocks enzymes that contribute to breast cancer growth.

• #47 Treatment of Breast Cancer in Men, by Stage | American Cancer Society

  https://www.cancer.org/cancer/types/breast-cancer-in-men/treating/by-stage.html

  This information is based on AJCC Staging systems prior to 2018 which were primarily based on tumor size and lymph node status. […] Because there have been few clinical trials on treatment of male breast cancer, most doctors base their treatment recommendations on their experience with the disease and on the results of studies of breast cancer in women. With some minor variations, breast cancer in men is treated the same way as breast cancer in women. […] The stage (extent) of your breast cancer is an important factor in making decisions about your treatment options. In general, the more the breast cancer has spread, the more treatment you will likely need. […] It is treated with surgery to remove the cancer. Most often in males, a mastectomy is done. If breast-conserving surgery is done, it is followed by radiation therapy to the remaining breast tissue.

• #48 Treatment of Breast Cancer in Men, by Stage | American Cancer Society

  https://www.cancer.org/cancer/types/breast-cancer-in-men/treating/by-stage.html

  The main treatment for stage I breast cancer is to remove it with surgery. This is usually done by mastectomy, but breast-conserving surgery (BCS) might occasionally be an option. If breast-conserving surgery is done, it is usually followed by radiation therapy. […] Hormone therapy, chemotherapy (chemo) and/or targeted therapy may be recommended as adjuvant (after surgery) therapy, based on the tumor size and results of lab tests. Hormone therapy with tamoxifen is usually recommended for hormone receptor-positive tumors. […] Systemic (drug) therapy is often recommended for men with stage II breast cancer. […] Radiation therapy may be given after surgery if the tumor is large or if it is found to have spread to several lymph nodes. […] Most often, these cancers are treated with chemo before surgery (neoadjuvant chemo).

• #49 Male Breast Cancer Treatment

  https://www.komen.org/breast-cancer/treatment/by-diagnosis/male-breast-cancer/

  Breast cancer can occur in men. This may be called male breast cancer. […] Treatment for breast cancer in men is similar to treatment for women. Treatment for early and locally advanced breast cancers includes some combination of: Surgery, Radiation therapy, Chemotherapy, Hormone therapy, HER2-targeted therapy, CDK4/6 inhibitor therapy, Immunotherapy, PARP inhibitor therapy. […] Breast cancer surgery in men is usually a mastectomy because of the small size of the male breast. Some men may choose to have breast reconstruction. Some men who have a mastectomy may also have radiation therapy after surgery, depending on the stage of the breast cancer. […] For men with hormone receptor-positive breast cancers, the hormone therapy drug tamoxifen, with or without the CDK4/6 inhibitor abemaciclib (Verzenio), is usually the first drug therapy used. Tamoxifen is a pill taken every day for 5-10 years.

• #50 Treatment of Breast Cancer in Men, by Stage | American Cancer Society

  https://www.cancer.org/cancer/types/breast-cancer-in-men/treating/by-stage.html

  The main treatment for stage I breast cancer is to remove it with surgery. This is usually done by mastectomy, but breast-conserving surgery (BCS) might occasionally be an option. If breast-conserving surgery is done, it is usually followed by radiation therapy. […] Hormone therapy, chemotherapy (chemo) and/or targeted therapy may be recommended as adjuvant (after surgery) therapy, based on the tumor size and results of lab tests. Hormone therapy with tamoxifen is usually recommended for hormone receptor-positive tumors. […] Systemic (drug) therapy is often recommended for men with stage II breast cancer. […] Radiation therapy may be given after surgery if the tumor is large or if it is found to have spread to several lymph nodes. […] Most often, these cancers are treated with chemo before surgery (neoadjuvant chemo).

• #51 Treatment of Breast Cancer in Men, by Stage | American Cancer Society

  https://www.cancer.org/cancer/types/breast-cancer-in-men/treating/by-stage.html

  The main treatment for stage I breast cancer is to remove it with surgery. This is usually done by mastectomy, but breast-conserving surgery (BCS) might occasionally be an option. If breast-conserving surgery is done, it is usually followed by radiation therapy. […] Hormone therapy, chemotherapy (chemo) and/or targeted therapy may be recommended as adjuvant (after surgery) therapy, based on the tumor size and results of lab tests. Hormone therapy with tamoxifen is usually recommended for hormone receptor-positive tumors. […] Systemic (drug) therapy is often recommended for men with stage II breast cancer. […] Radiation therapy may be given after surgery if the tumor is large or if it is found to have spread to several lymph nodes. […] Most often, these cancers are treated with chemo before surgery (neoadjuvant chemo).

• #52 Male Breast Cancer Treatment (PDQ®) – NCI

  https://www.cancer.gov/types/breast/hp/male-breast-treatment-pdq

  Surgical excision. […] Radiation therapy and endocrine therapy. […] Treatment options for men with metastatic breast cancer include: Aromatase inhibitor (AI) therapy in conjunction with a gonadotropin-releasing hormone (GnRH) agonist. […] The management of metastatic hormone receptor-positive male breast cancer relies on the same treatment options used in women. […] The use of chemotherapy, human epidermal growth factor receptor 2 (HER2)-targeted therapy, immunotherapy, and poly (ADP-ribose) polymerase (PARP) inhibitors in men with metastatic breast cancer is guided by similar treatment principles as in women.

• #53 Treating Male Breast Cancer: Understanding Your Options

  https://www.premiersurgicalnetwork.com/blog/treatment-options-for-male-breast-cancer?utm_source=loclisting&utm_medium=Organic&utm_campaign=directory-appt&utm_content=PSNUN&rsiCampaignId=43316

  Preoperative therapy: For larger tumors or certain subtypes of cancer, doctors may recommend systemic therapy before surgery. These therapies can include chemotherapy, targeted therapies, immunotherapy, and more. Having other therapies before surgery may make surgery easier to perform or could provide access to new options through clinical trials. […] Adjuvant therapy: This is treatment given after surgery. The goal is to reduce the risk of recurrence and eliminate any remaining cancer cells in the body. Therapy may include chemotherapy, radiation, immunotherapy, and more. […] Our compassionate reconstructive surgeons work with your cancer team to craft personalized multi-modal plans to eradicate the cancer while retaining as much healthy tissue as possible.

• #54 Treatment of Breast Cancer in Men, by Stage | American Cancer Society

  https://www.cancer.org/cancer/types/breast-cancer-in-men/treating/by-stage.html

  Systemic (drug) therapy is the main treatment for stage IV breast cancer in men. Depending on many factors, this may be hormone therapy, chemo, targeted therapy, immunotherapy, or some combination of these treatments. […] Treatment for advanced breast cancer can often shrink or slow the growth of the cancer (sometimes for many years), but after a time it may stop working. […] For some men, breast cancer may come back after treatment sometimes years later. This is called a recurrence. […] Treatment depends on what other treatments have been given already. The treatment for local recurrence may be additional surgery followed by radiation therapy. […] Systemic treatment (such as hormone therapy, chemo, targeted therapy, or some combination of these) may be used after surgery and/or radiation therapy. […] Men who have a recurrence in places such as the bones, lungs, brain, etc., are often treated the same way as those found to have stage IV breast cancer with spread to these organs when they were first diagnosed.

• #55 Male Breast Cancer Treatment (PDQ®) – PDQ Cancer Information Summaries – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK65980/

  Hormone therapy with an aromatase inhibitor is given to some men who have metastatic breast cancer. […] Targeted therapy is a type of treatment that uses drugs or other substances to identify and attack specific cancer cells. […] In men with metastatic breast cancer that is hormone receptor positive and has not responded to other treatments, options may include targeted therapy such as trastuzumab, lapatinib, pertuzumab, or mTOR inhibitors. […] In men with metastatic breast cancer that is hormone receptor negative, has not responded to hormone therapy, has spread to other organs or has caused symptoms, treatment may include chemotherapy with one or more drugs. […] Total mastectomy for men with open or painful breast lesions. […] Radiation therapy to the bones, brain, spinal cord, breast, or chest wall to relieve symptoms and improve quality of life.

• #56 Male Breast Cancer Treatment (PDQ®) – NCI

  https://www.cancer.gov/types/breast/hp/male-breast-treatment-pdq

  Surgical excision. […] Radiation therapy and endocrine therapy. […] Treatment options for men with metastatic breast cancer include: Aromatase inhibitor (AI) therapy in conjunction with a gonadotropin-releasing hormone (GnRH) agonist. […] The management of metastatic hormone receptor-positive male breast cancer relies on the same treatment options used in women. […] The use of chemotherapy, human epidermal growth factor receptor 2 (HER2)-targeted therapy, immunotherapy, and poly (ADP-ribose) polymerase (PARP) inhibitors in men with metastatic breast cancer is guided by similar treatment principles as in women.

• #57 Treatment for breast cancer in men | Breast Cancer Now

  https://breastcancernow.org/about-breast-cancer/treatment/treatment-for-breast-cancer-in-men

  Learn about treatment for breast cancer in men, including chemotherapy, radiotherapy and hormone therapy, and understand the possible side effects. […] Treatment for breast cancer in men may include: Surgery, Chemotherapy, Radiotherapy, Hormone (endocrine) therapy, Targeted therapy. […] If the cancer has not spread beyond the breast tissue or the lymph nodes under the arm (primary breast cancer), treatment aims to remove the cancer and reduce the risk of it coming back or spreading to other parts of the body. […] If the cancer has spread to another part of the body, known as secondary breast cancer, treatment can be given to control and slow the spread of the cancer, relieve symptoms and give you the best quality of life for as long as possible. […] Surgery to remove the cancer is the first treatment for most men.

• #58 Treatment of Breast Cancer in Men, by Stage | American Cancer Society

  https://www.cancer.org/cancer/types/breast-cancer-in-men/treating/by-stage.html

  Systemic (drug) therapy is the main treatment for stage IV breast cancer in men. Depending on many factors, this may be hormone therapy, chemo, targeted therapy, immunotherapy, or some combination of these treatments. […] Treatment for advanced breast cancer can often shrink or slow the growth of the cancer (sometimes for many years), but after a time it may stop working. […] For some men, breast cancer may come back after treatment sometimes years later. This is called a recurrence. […] Treatment depends on what other treatments have been given already. The treatment for local recurrence may be additional surgery followed by radiation therapy. […] Systemic treatment (such as hormone therapy, chemo, targeted therapy, or some combination of these) may be used after surgery and/or radiation therapy. […] Men who have a recurrence in places such as the bones, lungs, brain, etc., are often treated the same way as those found to have stage IV breast cancer with spread to these organs when they were first diagnosed.

• #59 Male Breast Cancer | UCSF Department of Surgery

  https://surgery.ucsf.edu/condition/male-breast-cancer

  Treatment for male breast cancer may cause side effects. […] Treatment of early, localized, or operable breast cancer may include the following: Initial surgery, Adjuvant therapy. […] For men with locally recurrent disease (cancer that has come back in a limited area after treatment), treatment options include: Surgery, Radiation therapy combined with chemotherapy. […] Treatment options for metastatic breast cancer (cancer that has spread to distant parts of the body) may include the following: Hormone therapy, Targeted therapy, Chemotherapy, Surgery, Radiation therapy, Other treatment options.

• #60 Treatment of Breast Cancer in Men, by Stage | American Cancer Society

  https://www.cancer.org/cancer/types/breast-cancer-in-men/treating/by-stage.html

  Systemic (drug) therapy is the main treatment for stage IV breast cancer in men. Depending on many factors, this may be hormone therapy, chemo, targeted therapy, immunotherapy, or some combination of these treatments. […] Treatment for advanced breast cancer can often shrink or slow the growth of the cancer (sometimes for many years), but after a time it may stop working. […] For some men, breast cancer may come back after treatment sometimes years later. This is called a recurrence. […] Treatment depends on what other treatments have been given already. The treatment for local recurrence may be additional surgery followed by radiation therapy. […] Systemic treatment (such as hormone therapy, chemo, targeted therapy, or some combination of these) may be used after surgery and/or radiation therapy. […] Men who have a recurrence in places such as the bones, lungs, brain, etc., are often treated the same way as those found to have stage IV breast cancer with spread to these organs when they were first diagnosed.

• #61 Program for Breast Cancer in Men | Dana-Farber Cancer Institute

  https://www.dana-farber.org/cancer-care/treatment/breast-oncology/programs/breast-cancer-in-men

  For the roughly 2,600 men who are diagnosed with breast cancer in the United States annually, the news can be very surprising. […] We offer cutting-edge oncologic care, as well as emotional and psychosocial support services and coordination of care with other providers. […] Our ongoing research will be key to advancing our understanding of this disease, and to developing the best therapies. […] Treatment can include chemotherapy, endocrine therapy, radiation, and surgery. However, there are some important differences with regard to surgery, radiation therapy, and endocrine therapy. […] Because most breast cancers in men are hormonally sensitive (in other words, the estrogen and/or progesterone receptor are expressed on the tumor cells), drugs like tamoxifen (a blocker of the estrogen receptor) are very commonly prescribed to men. […] The outcomes for men with breast cancer are generally similar to those of women diagnosed at a similar stage. […] Current treatments are highly effective for most men, and new breast cancer therapies are being developed all the time.

• #62 Shining a Spotlight on Expanding Treatment Options for Male Breast Cancer  – Susan G. Komen®

  https://www.komen.org/blog/spotlight-on-ethan-clinical-trial/

  Breast cancer is often thought of as a disease that primarily affects women, but men also have a small amount of breast tissue, which means they can get breast cancer too. […] With these numbers, new research is emerging, aiming to expand treatment options for male breast cancer. […] Komen grantee Jose Pablo Leone, M.D., believes this is because most of these men receive a mastectomy and tamoxifen a hormone therapy that has remained the standard of care for male breast cancer for three decades. […] In this study, Dr. Leone and his team are comparing the effectiveness of different hormone therapies (also called endocrine therapies) in men with stage 1-3 estrogen receptor-positive (ER+), human epidermal growth factor receptor 2 negative (HER2-) breast cancer, with the hope of finding better treatment options beyond tamoxifen, which is the current standard of care for these patients.

• #63 Shining a Spotlight on Expanding Treatment Options for Male Breast Cancer  – Susan G. Komen®

  https://www.komen.org/blog/spotlight-on-ethan-clinical-trial/

  The ETHAN study will evaluate additional hormone treatments that have worked well in women with breast cancer to see if they can also provide more improved treatment options for men and with better outcomes. […] The main reason for doing the ETHAN trial is because we need to understand whether other treatment options are effective in men or not, Dr. Leone says. […] The ETHAN clinical trial is a multicenter, phase 2 randomized study for men with stage 1-3 ER+, HER2- breast cancer. […] Hopefully, with the results of ETHAN, we can find out whether tamoxifen should remain the standard of care or whether one of the other options is better, and also, what would be the best combination for endocrine therapy with CDK4/6 inhibitors in men, Dr. Leone says. […] One of the greatest potential benefits of the ETHAN study is giving men with breast cancer the opportunity to avoid side effects that come from tamoxifen, including blood clots, erectile dysfunction and muscular fatigue.

• #64 Can men get breast cancer? 10 things to know | MD Anderson Cancer Center

  https://www.mdanderson.org/cancerwise/male-breast-cancer-what-men-should-know.h00-158826489.html

  Breast cancer treatment is similar for men and women. It may include: surgery, chemotherapy, radiation therapy, hormone therapy, targeted therapy. […] Most men have breast cancers that are estrogen receptor positive. So, we often use tamoxifen to block estrogen as part of their treatment. […] Doctors and researchers are looking into using multi-cancer early detection tests to help catch cancer in its early stages when its easier to treat. […] In the last few years, I’ve seen a lot more interest concerning cosmetic results for male breast cancer patients. […] But results can be noticeable. Some men have a surgical scar across their chest or have a nipple removed. […] I think doctors have recognized that more. So now, when possible, we may consider a lumpectomy and radiation instead of a mastectomy.

• #65 Treating Breast Cancer in Men

  https://malebc.org/?page_id=1314

  Patients who have no detectable cancer after surgery are often given treatment to help keep the cancer from coming back. This is known as adjuvant therapy. […] Some patients are given treatment before surgery to shrink the tumor in the hope it will allow a less extensive operation to be done. This is called neoadjuvant therapy. […] Clinical trials are carefully controlled research studies that are done to get a closer look at promising new treatments or procedures. […] Complementary methods refer to treatments that are used along with your regular medical care. Alternative treatments are used instead of a doctors medical treatment. […] Your cancer care team will be your first source of information and support, but there are other resources for help when you need it.

• #66

  https://www.advocatehealth.com/health-services/cancer-institute/cancers-we-treat/breast-cancer/men

  Many details about treatment for breast cancer are similar for women and men. The mainstays of surgery, chemo, radiation therapy and hormone therapy are used. Different kinds of surgery may be recommended and nearby lymph nodes may also be tested to see if cancer has spread to them. […] One of the differences is the availability of clinical trials for breast cancer that focus on men. There are far fewer men diagnosed with breast cancer than women. Its hard to get a big enough group to study to provide meaningful results. Your participation in research about breast cancer in men could give you access to the latest treatments and help add to the understanding of this disease.

• #67 Management of Male Breast Cancer: ASCO Guideline – PubMed

  https://pubmed.ncbi.nlm.nih.gov/32058842/

  Many of the management approaches used for men with breast cancer are like those used for women. […] Men with hormone receptor-positive breast cancer who are candidates for adjuvant endocrine therapy should be offered tamoxifen for an initial duration of five years; those with a contraindication to tamoxifen may be offered a gonadotropin-releasing hormone agonist/antagonist plus aromatase inhibitor. […] Men with advanced or metastatic disease should be offered endocrine therapy as first-line therapy, except in cases of visceral crisis or rapidly progressive disease. […] Targeted systemic therapy may be used to treat advanced or metastatic cancer using the same indications and combinations offered to women. […] Genetic counseling and germline genetic testing of cancer predisposition genes should be offered to all men with breast cancer.

• #68 Men With Breast Cancer Need More Treatment Options and Access to Genetic Counseling | FDA

  https://www.fda.gov/consumers/consumer-updates/men-breast-cancer-need-more-treatment-options-and-access-genetic-counseling

  Although breast cancer is a disease usually associated with women, men can get it too. […] Because male breast cancer is rare, there is very limited information on how to treat men diagnosed with the disease. […] In the absence of better information to guide us, we tend to treat men with breast cancer the same way we treat women, says Tatiana M. Prowell, M.D., a breast cancer scientific liaison at the U.S. Food and Drug Administration. […] The FDA finalized a guidance, Male Breast Cancer: Developing Drugs for Treatment, to help facilitate drug development for men with breast cancer. The guidance recommends the inclusion of men in clinical trials of breast cancer drugs unless there is a scientific reason for their exclusion. […] Treatment options for men are similar to womens: mastectomy, which is surgery to remove the breast, or in some cases lumpectomy, radiation, chemotherapy, targeted therapies, and hormone therapy. Hormone drug treatments include aromatase inhibitors or tamoxifen, which lower estrogen levels in the bloodstream or prevent estrogen in the bloodstream from interacting with estrogen receptors on breast cancer cells.

• #69 Male Breast Cancer | Diagnosis and Treatment | University of Michigan Rogel Cancer Center

  https://www.rogelcancercenter.org/breast-cancer/male-breast-cancer

  Male breast cancer is usually treated with surgery to remove the breast (mastectomy) and some lymph nodes. In some cases, breast-conserving therapy (lumpectomy + radiation) is possible. […] Male breast cancer is similar to female breast cancer so many of the same treatments are used. These include radiation therapy, chemotherapy, anti-estrogen therapy, and targeted therapy.

• #70 Male Breast Cancer Treatment – NCI

  https://www.cancer.gov/types/breast/patient/male-breast-treatment-pdq

  Male breast cancer is a disease in which malignant (cancer) cells form in the tissues of the breast. […] The treatment of male breast cancer depends partly on the stage of the disease. […] Five types of standard treatment are used to treat men with breast cancer: Surgery, Chemotherapy, Hormone therapy, Radiation therapy, Targeted therapy. […] Treatment for male breast cancer may cause side effects. […] Surgery for men with breast cancer is usually a modified radical mastectomy, surgery to remove the whole breast that has cancer. […] Hormone therapy is a cancer treatment that removes hormones or blocks their action and stops cancer cells from growing. […] Hormone therapy with tamoxifen is often given to patients with estrogen-receptor and progesterone-receptor positive breast cancer and to patients with metastatic breast cancer (cancer that has spread to other parts of the body).

• #71 Program for Breast Cancer in Men | Dana-Farber Cancer Institute

  https://www.dana-farber.org/cancer-care/treatment/breast-oncology/programs/breast-cancer-in-men

  For the roughly 2,600 men who are diagnosed with breast cancer in the United States annually, the news can be very surprising. […] We offer cutting-edge oncologic care, as well as emotional and psychosocial support services and coordination of care with other providers. […] Our ongoing research will be key to advancing our understanding of this disease, and to developing the best therapies. […] Treatment can include chemotherapy, endocrine therapy, radiation, and surgery. However, there are some important differences with regard to surgery, radiation therapy, and endocrine therapy. […] Because most breast cancers in men are hormonally sensitive (in other words, the estrogen and/or progesterone receptor are expressed on the tumor cells), drugs like tamoxifen (a blocker of the estrogen receptor) are very commonly prescribed to men. […] The outcomes for men with breast cancer are generally similar to those of women diagnosed at a similar stage. […] Current treatments are highly effective for most men, and new breast cancer therapies are being developed all the time.

• #72 Can men get breast cancer? 10 things to know | MD Anderson Cancer Center

  https://www.mdanderson.org/cancerwise/male-breast-cancer-what-men-should-know.h00-158826489.html

  Male breast cancer is curable in most cases. Curability depends on the cancers stage at diagnosis. […] In general, the survival rate for men diagnosed with breast cancer is slightly lower than it is for women. […] Remember every situation is unique, so its important to speak to your doctor about your prognosis. […] We are working to better understand this rare disease and improve patients treatment options and quality of life.

• #73 Male Breast Cancer | Memorial Sloan Kettering Cancer Center

  https://www.mskcc.org/cancer-care/types/breast-male

  Treatment of Male Breast Cancer […] The treatments for male breast cancer are very similar to the ones for female breast cancer. They may include chemotherapy, radiation therapy, and/or surgery, such a lumpectomy (removal of the tumor) or mastectomy (removal of the full breast). Sometimes, a combination of these approaches offers the best chance of successful treatment. Learn more about breast cancer treatments. […] Because there are so few cases of male breast cancer, it is important to choose a care team that is trained in treating the disease. […] The Rare Breast Cancer Program at MSK has that experience. We evaluate and treat about 200 people with early- or advanced-stage rare breast cancer, including male breast cancer, every year. […] When men with breast cancer come to MSK, they have access to streamlined, comprehensive care. We offer molecular testing to determine the genetic makeup of each persons tumor. We also provide genetic counseling so we can learn about any cancer predispositions that may affect them or members of their family. Our clinic for men with the BRCA gene ensures that men get the most information they can about their specific disease in an effort to determine which treatments may be best for them.

• #74 Male Breast Cancer | Memorial Sloan Kettering Cancer Center

  https://www.mskcc.org/cancer-care/types/breast-male

  We work with other MSK experts to ensure that you get the care you need beyond medical treatment. Experts in male sexual health, social work, integrative medicine, and other subspecialities can help you manage the stress of breast cancer treatment, as well as its potential side effects, such as chemotherapy-induced nausea, fatigue, loss of appetite, or lymphedema (buildup of fluid in the arm and hand). […] We know it is overwhelming to be diagnosed with male breast cancer, but we have the expertise and experience needed to give you the highest quality of care.

Zobacz więcej