Materiały źródłowe

• #1 von Willebrand disease – Wikipedia

  https://en.wikipedia.org/wiki/Von_Willebrand_disease

  Von Willebrand disease (VWD) is the most common hereditary blood-clotting disorder in humans. […] VWD type 1 is the most common type of the disorder, with mild bleeding symptoms such as nosebleeds, though occasionally more severe symptoms can occur. […] The various types of VWD present with varying degrees of bleeding tendency, usually in the form of easy bruising, nosebleeds, and bleeding gums. Women may experience heavy menstrual periods and blood loss during childbirth. […] Severe internal bleeding and bleeding into joints are uncommon in all but the most severe type, VWD type 3. […] Many patients are asymptomatic or may have mild symptoms and not have clearly impaired clotting, which might suggest a bleeding disorder. Often, the discovery of low VWF occurs incidentally to other medical procedures requiring a blood work-up. Most cases of low VWF are never diagnosed due to its asymptomatic or mild presentation, and most people with type I VWD end up leading a normal life free of complications, with many being unaware that they have the disorder.

• #2 Von Willebrand Disease in Women | ACOG

  https://www.acog.org/clinical/clinical-guidance/committee-opinion/articles/2013/12/von-willebrand-disease-in-women

  Von Willebrand disease, the most common inherited bleeding disorder among American women, is a common cause of heavy menstrual bleeding and other bleeding problems in women and adolescent girls. […] Abnormal uterine bleeding is a commonly reported symptom among women with a diagnosis of von Willebrand disease, with 74-92% experiencing heavy menstrual bleeding. Additional symptoms or signs that may be present include epistaxis (38-63%), gingival bleeding (26-35%), bleeding after dental extraction (29-52%), bleeding from minor cuts or abrasions (36%), postoperative bleeding (20-28%), gastrointestinal bleeding (14%), and joint bleeding (6-8%). […] Once a diagnosis of von Willebrand disease has been established, a multidisciplinary approach to management, which involves obstetrician-gynecologists and hematologists, results in optimal treatment outcomes.

• #3 Sign up for our newsletter

  https://www.pbi.org.au/vwd-von-willebrand-disease

  VWD is one of the most common bleeding disorders worldwide and affects approximately 1% of the population, both male and female. However, women are more likely to experience symptoms associated with VWD due to the bleeding which occurs during menstruation, pregnancy, and post-partum. […] Excess gynaecological bleeding is increased in women with VWD, with post-partum haemorrhage increasing 1.5 times. There is also a 5-fold risk of blood transfusion and a higher risk of death by 10-fold. Women with VWD also have an increased risk of post-partum bleeding up to 6-weeks following delivery; 30% compared to 2% among women without the condition. […] If you have VWD, you may have the following general symptoms: Excessive bleeding from an injury or after dental work or surgery. Frequent nosebleeds which do not stop after about 10 minutes. Blood in the urine or stool. Easy bruising or lumpy bruises.

• #4 Von Willebrand disease // Middlesex Health

  https://middlesexhealth.org/learning-center/diseases-and-conditions/von-willebrand-disease

  Many people with von Willebrand disease don’t know it because the signs are mild or absent. The most common sign of the condition is abnormal bleeding. […] If you have von Willebrand disease, you might have: Excessive bleeding from an injury or after surgery or dental work, Frequent nosebleeds that don’t stop within 10 minutes, Heavy or long menstrual bleeding, Heavy bleeding during labor and delivery, Blood in your urine or stool, Easy bruising or lumpy bruises. […] Menstrual signs and symptoms might include: Blood clots greater than 1 inch (2.5 centimeters) in diameter in your menstrual flow, The need to change your menstrual pad or tampon more than once an hour, The need to use double sanitary protection for menstrual flow, Symptoms of anemia, including tiredness, fatigue or shortness of breath.

• #5 Signs, Symptoms, and Complications of Von Willebrand Disease | Hematology-Oncology Associates of CNY

  https://www.hoacny.com/patient-resources/blood-disorders/what-von-willebrand-disease/signs-symptoms-and-complications-von

  The signs and symptoms of von Willebrand disease (VWD) depend on which type of the disorder you have. They also depend on how serious the disorder is. Many people have such mild symptoms that they don’t know they have VWD. […] If you have type 1 or type 2 VWD, you may have the following mild-to-moderate bleeding symptoms: Frequent, large bruises from minor bumps or injuries. Frequent or hard-to-stop nosebleeds. Prolonged bleeding from the gums after a dental procedure. Heavy or prolonged menstrual bleeding in women. Blood in your stools from bleeding in your intestines or stomach. Blood in your urine from bleeding in your kidneys or bladder. Heavy bleeding after a cut or other accident. Heavy bleeding after surgery. […] People who have type 3 VWD may have all of the symptoms listed above and severe bleeding episodes for no reason. These bleeding episodes can be fatal if not treated right away. People who have type 3 VWD also may have bleeding into soft tissues or joints, causing severe pain and swelling.

• #6 Von Willebrand disease | Great Ormond Street Hospital

  https://www.gosh.nhs.uk/conditions-and-treatments/conditions-we-treat/von-willebrand-disease/

  In many cases, the condition is so mild that there are no noticeable symptoms. […] The severity of symptoms depends greatly on the level of Von Willebrand Factor (and therefore Factor VIII) in the blood. […] When the level of Von Willebrand Factor is low or absent or it does not work properly symptoms will be present, often early in life. […] People with moderate to severe Von Willebrand Disease may bruise more easily than usual and may bleed for longer after injury or more severely following surgery or dental work. […] Generally only people with Type 3 Von Willebrand disease have spontaneous bleeds often from the nose or mouth and sometimes internally, for instance in the digestive system. […] Women with Von Willebrand disease often have heavy periods.

• #7 Haemophilia and Von Willebrand Disease | Ausmed

  https://www.ausmed.com/learn/articles/bleeding-disorders

  Von Willebrand disease (VWD) is the most common bleeding disorder around the world, affecting people of all genders and racial backgrounds (Better Health Channel 2022a). The disorder is caused by an absent or dysfunctional von Willebrand factor (VWF), which slows or impairs the blood clotting process. Consequently, bleeding takes longer to stop than in the average person (Better Health Channel 2022a). […] In VWD, bleeding generally affects the mucous membranes (nose, mouth, uterus, vagina, stomach, and intestines) (Better Health Channel 2022a). Some people with mild illness have no noticeable symptoms and may not even be aware that they have the disorder (Healthdirect 2020). Symptomatic people might experience: […] Frequent or long-lasting nosebleeds that may occur without injury, last for more than 10 minutes and/or require packing or cautery […] Frequent and easy bruising […] Heavy or prolonged menstrual bleeding – this is often the most significant indicator of the disorder in women […] Excessive bleeding after injury, surgery, childbirth, or dental procedures […] Bleeding from the gum […] Blood in urine or stools […] Spontaneous bleeding episodes, in severe cases […] Bleeding into joints or internal organs, in severe cases (CDC 2023; Healthdirect 2020; Doherty Kelley 2023). […] Milder cases of VWD may not be recognised until a major bleeding problem occurs and indicates that something is abnormal (e.g. after surgery or an injury) (Better Health Channel 2022a).

• #8 Von Willebrand disease: MedlinePlus GeneticsLock

  https://medlineplus.gov/genetics/condition/von-willebrand-disease/

  Von Willebrand disease is a bleeding disorder that slows the blood clotting process, causing prolonged bleeding after an injury. People with this condition often experience easy bruising, long-lasting nosebleeds, and excessive bleeding or oozing following an injury, surgery, or dental work. […] In severe cases of von Willebrand disease, heavy bleeding occurs after minor trauma or even in the absence of injury (spontaneous bleeding). Symptoms of von Willebrand disease may change over time. Increased age, pregnancy, exercise, and stress may cause bleeding symptoms to become less frequent. […] People with this condition who have menstrual periods typically have heavy or prolonged bleeding during menstruation (menorrhagia), and some may also experience reproductive tract bleeding during pregnancy and childbirth.

• #9 Von Willebrand disease | Better Health Channel

  https://www.betterhealth.vic.gov.au/health/conditionsandtreatments/von-willebrand-disease

  The types of symptoms a person with VWD experiences can change over their lifetime. For example, they may have nosebleeds and easy bruising as a child and find this occurs less often as they grow older. However, their type of VWD will not change. […] Women are more likely to show symptoms of VWD than men. Without treatment, women with VWD often bleed more or for longer than normal with menstruation (their period). […] Some women with VWD also have heavy bleeding a few days or weeks after giving birth, or pregnancy loss. Some women also have a lot of period pain or irregular periods. However, these symptoms are not always related to VWD and may have other causes. An assessment by a gynaecologist is an important part of understanding and treating these symptoms effectively.

• #10 Von Willebrand disease // Middlesex Health

  https://middlesexhealth.org/learning-center/diseases-and-conditions/von-willebrand-disease

  Many people with von Willebrand disease don’t know it because the signs are mild or absent. The most common sign of the condition is abnormal bleeding. […] If you have von Willebrand disease, you might have: Excessive bleeding from an injury or after surgery or dental work, Frequent nosebleeds that don’t stop within 10 minutes, Heavy or long menstrual bleeding, Heavy bleeding during labor and delivery, Blood in your urine or stool, Easy bruising or lumpy bruises. […] Menstrual signs and symptoms might include: Blood clots greater than 1 inch (2.5 centimeters) in diameter in your menstrual flow, The need to change your menstrual pad or tampon more than once an hour, The need to use double sanitary protection for menstrual flow, Symptoms of anemia, including tiredness, fatigue or shortness of breath.

• #11 About von Willebrand Disease | Von Willebrand Disease (VWD) | CDC

  https://www.cdc.gov/von-willebrand/about/index.html

  Von Willebrand disease (VWD) is a blood disorder in which the blood does not clot properly. […] Signs of VWD include nosebleeds, easy bruising, heavy menstrual bleeding, and longer than normal bleeding after injury, surgery, dental work, or childbirth. […] People with VWD might have nosebleeds that start without injury (spontaneous), occur often, usually five times or more in a year, last more than 10 minutes, and need packing or cautery to stop the bleeding. […] People with VWD might experience easy bruising that occurs with very little or no trauma or injury, occurs often (one to four times per month), is larger than the size of a quarter, and is not flat and has a raised lump. […] Women with VWD might have heavy menstrual periods during which they experience soaking through a pad or tampon every 12 hours (or more often) on the heaviest day(s), menstrual bleeding that lasts longer than 7 days from the time bleeding starts until the time it ends, flooding or gushing of blood, passing blood clots larger than the size of grapes or strawberries, and a diagnosis of anemia as a result of bleeding from heavy periods.

• #12 Von Willebrand disease

  https://www.nhs.uk/conditions/von-willebrand-disease/

  Von Willebrand disease does not always cause symptoms unless you have an injury. Sometimes it’s found when you have more bleeding than usual after surgery or giving birth. […] Symptoms of von Willebrand disease can include: bruising easily, frequent nosebleeds, bleeding gums, bleeding more than usual after an injury or cut, heavy periods. […] Some people also have more severe symptoms, such as: heavy bleeding that’s difficult to stop, for example after an injury or procedure, blood in your poo, blood in your pee (urine), pain, swelling and stiffness in a joint. […] If tests show you have von Willebrand disease, the specialist will tell you which type you have. Types 1 and 2 are the most common and usually cause mild symptoms. Type 3 is rare and causes more severe symptoms. […] If you have type 1 or type 2 and mild symptoms you’ll only need treatment when you get more serious bleeding, or to help prevent bleeding, for example before surgery or dental treatment. […] If you have type 3 or more severe symptoms you may also need regular treatment to help prevent bleeding.

• #13 von Willebrand Disease: What It Is, Types, Symptoms & Treatment

  https://my.clevelandclinic.org/health/diseases/17709-von-willebrand-disease

  People with von Willebrand disease may bleed more than usual. For example, they may have frequent nosebleeds or bleed for a long time after getting a minor cut. […] Women may have heavy menstrual periods or heavy bleeding after giving birth. People who have the most serious form of von Willebrand disease may have bleeding into their joints or soft tissues that cause severe pain and swelling. Some people develop anemia. […] Many people with von Willebrand disease have the condition, but dont have symptoms or have mild symptoms. People who have a more severe form of the condition may have the following symptoms: […] Nosebleeds: These are nosebleeds that last longer than 10 minutes and happen five or more times a year. […] Bleeding from a cut or other injury that lasts longer than 10 minutes.

• #14 von Willebrand disease – Wikipedia

  https://en.wikipedia.org/wiki/Von_Willebrand_disease

  Trouble may, however, arise in some patients in the form of bleeding following surgery (including dental procedures), noticeable easy bruising, or menorrhagia (heavy menstrual periods). The minority of cases of type 1 may present with severe hemorrhagic symptoms. […] VWD type 3 is a rare but the most severe form of VWD. It occurs in individuals who are homozygous for the defective gene, resulting in a severe quantitative deficiency or complete absence of von Willebrand factor (VWF) production. In VWD type 3, VWF is undetectable in the VWF antigen assay. Since VWF normally protects coagulation factor VIII from proteolytic degradation, the total absence of VWF leads to extremely low factor VIII levels (typically 1-10%). These low levels are equivalent to those seen in severe hemophilia A, with clinical manifestations of life-threatening external and internal hemorrhages.

• #15 Von Willebrand disease

  https://www.nhs.uk/conditions/von-willebrand-disease/

  Von Willebrand disease does not always cause symptoms unless you have an injury. Sometimes it’s found when you have more bleeding than usual after surgery or giving birth. […] Symptoms of von Willebrand disease can include: bruising easily, frequent nosebleeds, bleeding gums, bleeding more than usual after an injury or cut, heavy periods. […] Some people also have more severe symptoms, such as: heavy bleeding that’s difficult to stop, for example after an injury or procedure, blood in your poo, blood in your pee (urine), pain, swelling and stiffness in a joint. […] If tests show you have von Willebrand disease, the specialist will tell you which type you have. Types 1 and 2 are the most common and usually cause mild symptoms. Type 3 is rare and causes more severe symptoms. […] If you have type 1 or type 2 and mild symptoms you’ll only need treatment when you get more serious bleeding, or to help prevent bleeding, for example before surgery or dental treatment. […] If you have type 3 or more severe symptoms you may also need regular treatment to help prevent bleeding.

• #16 Von Willebrand Disease (for Parents) | Nemours KidsHealth

  https://kidshealth.org/en/parents/vwd.html

  Many kids with VWD have such mild symptoms that they never know they have it. […] Symptoms of Von Willebrand disease can include: having a lot of nosebleeds, easy bruising that happens a lot, in girls, heavy, long-lasting periods, long-lasting or a lot of bleeding during and after procedures (a tooth extraction, tonsillectomy, etc.), cuts that ooze blood for longer than usual, bleeding in the mucous membranes, such as the gums, nose, and lining of the gastrointestinal system. […] In Type 1, the level of Von Willebrand factor in the blood is reduced and the level of factor VIII also might be reduced. This is the most common and mildest form of the disease. The symptoms might be so minor that the person isn’t ever diagnosed. People with type I VWD usually do not bleed spontaneously but can have a lot of bleeding with menstrual periods, trauma, or surgery, or when they have a tooth pulled. […] In Type 3, Von Willebrand factor and factor VIII levels are very low or missing. Symptoms are severe and may include bleeding into joints and muscles.

• #17 Von Willebrand Disease | Conditions | UCSF Benioff Children’s Hospitals

  https://www.ucsfbenioffchildrens.org/conditions/von-willebrand-disease

  Von Willebrand Disease (vWD) is a bleeding disorder that slows down the blood clotting process, which can lead to excessive bleeding after injury, surgery or dental work along with nosebleeds, easy bruising and heavy menstrual periods. […] Symptoms include frequent bruising, excessive bleeding after a pulled tooth and bleeding in the muscous membranes, such as nose and gums. […] There are three forms of vWD type 1, 2 and 3 and the symptoms vary depending on the type and severity of the disease. […] Type 1: This is the most common and mildest form of the disease, where levels of von Willebrand factor (vWF) are slightly lower than normal. […] Type 2: This type, which is divided into several subtypes, is where the vWF is not working properly. […] Type 3: This is the most severe form, where the body produces very little, if any, vWF and there are very low levels of clotting factor VIII. This form can cause severe bleeding problems and is very rare.

• #18 Von Willebrand disease – types, symptoms, diagnosis and treatment | healthdirect

  https://www.healthdirect.gov.au/von-willebrand-disease

  Von Willebrand disease is the most common genetic bleeding disorder you can inherit from your parents. […] If you have von Willebrand disease your blood may take longer to clot and stop bleeding. […] Symptoms of von Willebrand disease can include bruising easily, very heavy or long menstrual periods, prolonged and excessive bleeding after a cut, injury, medical procedure or childbirth. […] The most common VWD symptoms are: bruising easily, very heavy or long menstrual periods, prolonged and excessive bleeding after a cut, injury, surgery, childbirth or dental work, frequent or long-lasting nosebleeds, gum bleeds. […] Older people might have rarer symptoms of blood in their urine or stools. […] If you have severe VWD you may have: bleeding into your joints and muscles causing swelling and pain, spontaneous bleeding episodes for no obvious reason. […] If you have VWD, your symptoms may change throughout your life. […] Many people who have VWD do not have symptoms.

• #19 Von Willebrand Disease | Haemophilia New Zealand

  https://www.haemophilia.org.nz/about-bleeding-disorders/von-willebrand-disease

  Symptoms are usually very mild and many people with vWD will lead normal active lives, with no need for treatment. Symptoms can include regular nosebleeds, bruising, and in women, heavy periods. […] Symptoms are usually moderate and can include regular nosebleeds, bruising and, in women, heavy periods. […] Symptoms are more severe. In addition to symptoms associated with milder forms of vWD, people with Type 3 vWD can have bleeding into muscles and joints, sometimes without obvious injury as they also have low levels of factor VIII, like people with haemophilia A. […] The first indications of vWD may be noticed after a minor surgical procedure (such as a tooth extraction), where prolonged bleeding might be observed. Other symptoms may include frequent nosebleeds, heavy menstruation, and bleeding after invasive surgery.

• #20 Signs, Symptoms, and Complications of Von Willebrand Disease | Hematology-Oncology Associates of CNY

  https://www.hoacny.com/patient-resources/blood-disorders/what-von-willebrand-disease/signs-symptoms-and-complications-von

  The signs and symptoms of von Willebrand disease (VWD) depend on which type of the disorder you have. They also depend on how serious the disorder is. Many people have such mild symptoms that they don’t know they have VWD. […] If you have type 1 or type 2 VWD, you may have the following mild-to-moderate bleeding symptoms: Frequent, large bruises from minor bumps or injuries. Frequent or hard-to-stop nosebleeds. Prolonged bleeding from the gums after a dental procedure. Heavy or prolonged menstrual bleeding in women. Blood in your stools from bleeding in your intestines or stomach. Blood in your urine from bleeding in your kidneys or bladder. Heavy bleeding after a cut or other accident. Heavy bleeding after surgery. […] People who have type 3 VWD may have all of the symptoms listed above and severe bleeding episodes for no reason. These bleeding episodes can be fatal if not treated right away. People who have type 3 VWD also may have bleeding into soft tissues or joints, causing severe pain and swelling.

• #21 Von Willebrand Disease: Symptoms, Causes, Diagnosis, Treatment

  https://www.webmd.com/a-to-z-guides/von-willebrand-disease-vwd

  With Type 1 and Type 2, your symptoms can range from mild to moderate. They include: […] If you’re a woman with VWD, you’ll have periods with clots larger than an inch in diameter. This means you may need to change your pad or tampon more than every hour. You’ll also likely develop anemia (low iron in the blood). These are symptoms of von Willebrand disease, but by themselves, they don’t prove you have VWD. […] With Type 3, you may have all the symptoms of Type 1 and Type 2, plus episodes of severe bleeding for no reason. You also might experience severe pain and swelling in your soft tissues and joints because of bleeding.

• #22 Von Willebrand Disease – Together by St. Jude™

  https://together.stjude.org/en-us/conditions/blood-disorders/von-willebrand-disease.html

  Von Willebrand disease (VWD) is a genetic bleeding disorder that affects the bloods ability to form clots. A person with von Willebrand disease may have increased bruising, prolonged nosebleeds, mouth bleeds, heavy menstrual periods, or heavy bleeding thats hard to stop after an injury or procedure. […] The signs and symptoms depend on the type of von Willebrand disease a person has and how severe the disorder is. […] With type 1 or type 2 von Willebrand disease, a person may have signs and symptoms of mild-to-moderate bleeding: Frequent bruising from minor bumps or injuries, Large bruises or bruises you can feel, Heavy bleeding after a cut or other injury, Heavy bleeding after surgery, Frequent nosebleeds that are hard to stop, Prolonged gum bleeding after teeth brushing or a dental procedure, Prolonged menstrual bleeding (periods), Blood in the stools from bleeding in the stomach or intestines, Blood in the urine from bleeding in the bladder or kidneys.

• #23 Von Willebrand Disease (for Parents) | Nemours KidsHealth

  https://kidshealth.org/en/parents/vwd.html

  Many kids with VWD have such mild symptoms that they never know they have it. […] Symptoms of Von Willebrand disease can include: having a lot of nosebleeds, easy bruising that happens a lot, in girls, heavy, long-lasting periods, long-lasting or a lot of bleeding during and after procedures (a tooth extraction, tonsillectomy, etc.), cuts that ooze blood for longer than usual, bleeding in the mucous membranes, such as the gums, nose, and lining of the gastrointestinal system. […] In Type 1, the level of Von Willebrand factor in the blood is reduced and the level of factor VIII also might be reduced. This is the most common and mildest form of the disease. The symptoms might be so minor that the person isn’t ever diagnosed. People with type I VWD usually do not bleed spontaneously but can have a lot of bleeding with menstrual periods, trauma, or surgery, or when they have a tooth pulled. […] In Type 3, Von Willebrand factor and factor VIII levels are very low or missing. Symptoms are severe and may include bleeding into joints and muscles.

• #24 von Willebrand disease – Wikipedia

  https://en.wikipedia.org/wiki/Von_Willebrand_disease

  Trouble may, however, arise in some patients in the form of bleeding following surgery (including dental procedures), noticeable easy bruising, or menorrhagia (heavy menstrual periods). The minority of cases of type 1 may present with severe hemorrhagic symptoms. […] VWD type 3 is a rare but the most severe form of VWD. It occurs in individuals who are homozygous for the defective gene, resulting in a severe quantitative deficiency or complete absence of von Willebrand factor (VWF) production. In VWD type 3, VWF is undetectable in the VWF antigen assay. Since VWF normally protects coagulation factor VIII from proteolytic degradation, the total absence of VWF leads to extremely low factor VIII levels (typically 1-10%). These low levels are equivalent to those seen in severe hemophilia A, with clinical manifestations of life-threatening external and internal hemorrhages.

• #25 Von Willebrand Disease: Symptoms, Causes, Diagnosis, Treatment

  https://www.webmd.com/a-to-z-guides/von-willebrand-disease-vwd

  With Type 1 and Type 2, your symptoms can range from mild to moderate. They include: […] If you’re a woman with VWD, you’ll have periods with clots larger than an inch in diameter. This means you may need to change your pad or tampon more than every hour. You’ll also likely develop anemia (low iron in the blood). These are symptoms of von Willebrand disease, but by themselves, they don’t prove you have VWD. […] With Type 3, you may have all the symptoms of Type 1 and Type 2, plus episodes of severe bleeding for no reason. You also might experience severe pain and swelling in your soft tissues and joints because of bleeding.

• #26 Von Willebrand Disease | Condition | UT Southwestern Medical Center

  https://utswmed.org/conditions-treatments/von-willebrand-disease/

  Von Willebrand disease, a bleeding disorder that slows down the blood clotting process, affects up to 1% of people in the United States. Many people with this condition bleed for a long time due to injury, surgery, dental care, menstruation, or childbirth. […] Symptoms, which vary depending on the type and severity of the condition, include: Frequent, long-lasting nosebleeds; Bleeding for more than 10 minutes after sustaining a cut or injury; Frequent, easy bruising (bruises are often lumpy); Bleeding heavily after surgery or dental work; Heavy menstrual bleeding; Bleeding heavily following childbirth or miscarriage; Bloody urine or stool. […] People with severe von Willebrand disease may also have spontaneous bleeding episodes (bleeding for no apparent reason) and bleeding in the muscles and joints, resulting in pain and swelling. […] People with mild cases of von Willebrand disease may have no symptoms. Some people don’t realize they have it until they bleed at length following a surgical or dental procedure. […] It’s important to tell a doctor about any symptoms and to seek care if the bleeding does not stop.

• #27 Von Willebrand disease | Better Health Channel

  https://www.betterhealth.vic.gov.au/health/conditionsandtreatments/von-willebrand-disease

  Most people with VWD have few or no symptoms. The symptoms of VWD vary greatly from person to person. Even members of the same family may have different symptoms. […] The more common symptoms are: having nose bleeds often or that are difficult to stop, easy bruising, very heavy or long menstrual periods, bleeding for a long time with minor cuts, bleeding from the gums, bleeding after injury, surgery or dental work that continues for a long time, heavy or prolonged bleeding after giving birth. […] Less common symptoms that older people might experience are: blood in faeces (poo) from bleeding in the intestines or stomach, blood in urine from bleeding in the kidneys or bladder. […] People with severe forms of VWD, particularly type 3 VWD, may also have other bleeding problems similar to haemophilia, such as: bleeding episodes that are spontaneous or happen for no obvious reason, bleeding into joints and muscles which can cause swelling and pain.

• #28 Signs, Symptoms, and Complications of Von Willebrand Disease | Hematology-Oncology Associates of CNY

  https://www.hoacny.com/patient-resources/blood-disorders/what-von-willebrand-disease/signs-symptoms-and-complications-von

  The signs and symptoms of von Willebrand disease (VWD) depend on which type of the disorder you have. They also depend on how serious the disorder is. Many people have such mild symptoms that they don’t know they have VWD. […] If you have type 1 or type 2 VWD, you may have the following mild-to-moderate bleeding symptoms: Frequent, large bruises from minor bumps or injuries. Frequent or hard-to-stop nosebleeds. Prolonged bleeding from the gums after a dental procedure. Heavy or prolonged menstrual bleeding in women. Blood in your stools from bleeding in your intestines or stomach. Blood in your urine from bleeding in your kidneys or bladder. Heavy bleeding after a cut or other accident. Heavy bleeding after surgery. […] People who have type 3 VWD may have all of the symptoms listed above and severe bleeding episodes for no reason. These bleeding episodes can be fatal if not treated right away. People who have type 3 VWD also may have bleeding into soft tissues or joints, causing severe pain and swelling.

• #29 Von Willebrand Disease in Women | ACOG

  https://www.acog.org/clinical/clinical-guidance/committee-opinion/articles/2013/12/von-willebrand-disease-in-women

  Many treatment options are available for women with von Willebrand disease and heavy menstrual bleeding, including hormonal and nonhormonal therapies. […] The onset of heavy menses at menarche is often the first sign of von Willebrand disease. Among a cohort of 38 women with type 1 von Willebrand disease, retrospective analysis of bleeding symptoms revealed that heavy menstrual bleeding at menarche was the most common initial bleeding symptom, which occurred in 53% of women. […] Von Willebrand disease is a common cause of heavy menstrual bleeding and other bleeding problems in women and adolescent girls.

• #30 Sign up for our newsletter

  https://www.pbi.org.au/vwd-von-willebrand-disease

  VWD is one of the most common bleeding disorders worldwide and affects approximately 1% of the population, both male and female. However, women are more likely to experience symptoms associated with VWD due to the bleeding which occurs during menstruation, pregnancy, and post-partum. […] Excess gynaecological bleeding is increased in women with VWD, with post-partum haemorrhage increasing 1.5 times. There is also a 5-fold risk of blood transfusion and a higher risk of death by 10-fold. Women with VWD also have an increased risk of post-partum bleeding up to 6-weeks following delivery; 30% compared to 2% among women without the condition. […] If you have VWD, you may have the following general symptoms: Excessive bleeding from an injury or after dental work or surgery. Frequent nosebleeds which do not stop after about 10 minutes. Blood in the urine or stool. Easy bruising or lumpy bruises.

• #31 Von Willebrand disease // Middlesex Health

  https://middlesexhealth.org/learning-center/diseases-and-conditions/von-willebrand-disease

  Many people with von Willebrand disease don’t know it because the signs are mild or absent. The most common sign of the condition is abnormal bleeding. […] If you have von Willebrand disease, you might have: Excessive bleeding from an injury or after surgery or dental work, Frequent nosebleeds that don’t stop within 10 minutes, Heavy or long menstrual bleeding, Heavy bleeding during labor and delivery, Blood in your urine or stool, Easy bruising or lumpy bruises. […] Menstrual signs and symptoms might include: Blood clots greater than 1 inch (2.5 centimeters) in diameter in your menstrual flow, The need to change your menstrual pad or tampon more than once an hour, The need to use double sanitary protection for menstrual flow, Symptoms of anemia, including tiredness, fatigue or shortness of breath.

• #32 Signs, Symptoms, and Complications of Von Willebrand Disease | Hematology-Oncology Associates of CNY

  https://www.hoacny.com/patient-resources/blood-disorders/what-von-willebrand-disease/signs-symptoms-and-complications-von

  Heavy menstrual bleeding often is the main symptom of VWD in women. Doctors call this menorrhagia (men-o-RA-je-ah). They define it as: Bleeding with clots larger than about 1-inch in diameter. Anemia (low red blood cell count) or low blood iron. The need to change pads or tampons more than every hour. […] However, just because a woman has heavy menstrual bleeding doesn’t mean she has VWD.

• #33 About von Willebrand Disease | Von Willebrand Disease (VWD) | CDC

  https://www.cdc.gov/von-willebrand/about/index.html

  Von Willebrand disease (VWD) is a blood disorder in which the blood does not clot properly. […] Signs of VWD include nosebleeds, easy bruising, heavy menstrual bleeding, and longer than normal bleeding after injury, surgery, dental work, or childbirth. […] People with VWD might have nosebleeds that start without injury (spontaneous), occur often, usually five times or more in a year, last more than 10 minutes, and need packing or cautery to stop the bleeding. […] People with VWD might experience easy bruising that occurs with very little or no trauma or injury, occurs often (one to four times per month), is larger than the size of a quarter, and is not flat and has a raised lump. […] Women with VWD might have heavy menstrual periods during which they experience soaking through a pad or tampon every 12 hours (or more often) on the heaviest day(s), menstrual bleeding that lasts longer than 7 days from the time bleeding starts until the time it ends, flooding or gushing of blood, passing blood clots larger than the size of grapes or strawberries, and a diagnosis of anemia as a result of bleeding from heavy periods.

• #34 What is von Willebrand Disease?Learn about the most common bleeding disorder

  https://www.siemens-healthineers.com/hemostasis/what-is-von-willebrand-disease

  Frequent nosebleeds may be a symptom of VWD. […] Excessive bleeding from an injury or after surgery or dental work […] Frequent nosebleeds that do not stop within 10 minutes […] Heavy or long menstrual bleeding […] Heavy bleeding during labor and delivery […] Blood in urine or stool […] Easy bruising or lumpy bruises […] Menstrual signs and symptoms of VWD might include: Blood clots greater than 1 inch in diameter in your menstrual flow […] The need to change your menstrual pad or tampon more than once an hour […] The need to use double sanitary protection for menstrual flow […] Symptoms of anemia, including tiredness, fatigue, or shortness of breath. […] A doctor should be consulted when you experience bleeding that lasts a long time or is difficult to stop.

• #35 Sign up for our newsletter

  https://www.pbi.org.au/vwd-von-willebrand-disease

  VWD is one of the most common bleeding disorders worldwide and affects approximately 1% of the population, both male and female. However, women are more likely to experience symptoms associated with VWD due to the bleeding which occurs during menstruation, pregnancy, and post-partum. […] Excess gynaecological bleeding is increased in women with VWD, with post-partum haemorrhage increasing 1.5 times. There is also a 5-fold risk of blood transfusion and a higher risk of death by 10-fold. Women with VWD also have an increased risk of post-partum bleeding up to 6-weeks following delivery; 30% compared to 2% among women without the condition. […] If you have VWD, you may have the following general symptoms: Excessive bleeding from an injury or after dental work or surgery. Frequent nosebleeds which do not stop after about 10 minutes. Blood in the urine or stool. Easy bruising or lumpy bruises.

• #36 von Willebrand disease – eLearning Platform

  https://elearning.wfh.org/elearning-centres/von-willebrand-disease/

  People with VWD can have few or no symptoms. People with more serious VWD may have more bleeding problems. Symptoms can also change over time or with age. […] More women than men show symptoms of VWD. Women with VWD often bleed more or longer than normal with menstruation (periods) and following childbirth. […] Women with VWD tend to have more symptoms than men because of menstruation (periods) and childbirth. Girls with VWD may have especially heavy bleeding when they begin to menstruate. Women with VWD often have heavier and/or longer periods. […] After the baby is born, it is normal to experience period-type bleeding that will improve over a number of weeks as the womb heals and returns to normal. It is not normal to bleed longer than 6 weeks or to experience the heavy bleeding signs above (such as changing pads/tampons more frequently than 2 hourly or passing clots larger than a pecan). […] Women with VWD entering menopause (end of menstruation, usually between the ages of 45 and 50) are at increased risk of unpredictable and heavy bleeding, even if their periods were previously normal.

• #37 Symptoms of von Willebrand disease | Hemophilia

  https://www.hemophilia.ca/symptoms-of-von-willebrand-disease/

  Heavy, prolonged menstrual bleeding is the most common symptom for women with VWD. Some women have heavy bleeding throughout the normal menstrual period. This is called menorrhagia. […] If women lose enough blood over a long period, they suffer from iron deficiency anemia. […] Menstrual bleeding can be especially heavy at the time of a girl’s first periods. […] After many years of battling heavy periods, one might expect women with VWD to look forward to menopause. In fact, hormone regulation becomes more chaotic as a woman gets closer to menopause and this increases her risk of unpredictable and heavy bleeding. […] Menorrhagia seriously affects a woman’s quality of life. Here are some examples. Women with menorrhagia caused by VWD may limit the amount of time they work, change careers as a result of bleeding problems, be unable to work normally during their menstrual periods, suffer constant fatigue from iron deficiency anemia, suffer from depression as a result of the strain of their bleeding disorder.

• #38 von Willebrand disease – eLearning Platform

  https://elearning.wfh.org/elearning-centres/von-willebrand-disease/

  People with VWD can have few or no symptoms. People with more serious VWD may have more bleeding problems. Symptoms can also change over time or with age. […] More women than men show symptoms of VWD. Women with VWD often bleed more or longer than normal with menstruation (periods) and following childbirth. […] Women with VWD tend to have more symptoms than men because of menstruation (periods) and childbirth. Girls with VWD may have especially heavy bleeding when they begin to menstruate. Women with VWD often have heavier and/or longer periods. […] After the baby is born, it is normal to experience period-type bleeding that will improve over a number of weeks as the womb heals and returns to normal. It is not normal to bleed longer than 6 weeks or to experience the heavy bleeding signs above (such as changing pads/tampons more frequently than 2 hourly or passing clots larger than a pecan). […] Women with VWD entering menopause (end of menstruation, usually between the ages of 45 and 50) are at increased risk of unpredictable and heavy bleeding, even if their periods were previously normal.

• #39 von Willebrand Disease Clinical Presentation: History, Physical Examination

  https://emedicine.medscape.com/article/206996-clinical

  Pediatric-specific bleeding that may occur in children with vWD include the following: […] Umbilical stump bleeding […] Cephalohematoma […] Cheek hematoma […] Conjunctival bleeding […] Post-circumcision bleeding […] Post-venipuncture bleeding. […] Physical examination findings are usually normal. However, patients may show physical sequelae, such as bleeding or bruises. The examiner should note the size, location, and distribution of any ecchymoses, hematomas, or petechiae, and should assess for evidence of risks of increased bleeding, such as the following: […] Jaundice or spider angiomata […] Splenomegaly […] Arthropathy […] Joint and skin laxity […] Telangiectasia.

• #40 von Willebrand Disease Clinical Presentation: History, Physical Examination

  https://emedicine.medscape.com/article/206996-clinical

  Pediatric-specific bleeding that may occur in children with vWD include the following: […] Umbilical stump bleeding […] Cephalohematoma […] Cheek hematoma […] Conjunctival bleeding […] Post-circumcision bleeding […] Post-venipuncture bleeding. […] Physical examination findings are usually normal. However, patients may show physical sequelae, such as bleeding or bruises. The examiner should note the size, location, and distribution of any ecchymoses, hematomas, or petechiae, and should assess for evidence of risks of increased bleeding, such as the following: […] Jaundice or spider angiomata […] Splenomegaly […] Arthropathy […] Joint and skin laxity […] Telangiectasia.

• #41 Von Willebrand Disease – Seattle Children’s

  https://www.seattlechildrens.org/conditions/von-willebrand-disease/

  Signs and symptoms of von Willebrand disease can be mild or serious. It depends on which type of the disease your child has. […] If your child’s disease is mild, you may not notice any sign of bleeding problems until a serious injury or surgery. Most children have a mild type. […] If your child’s disease is severe, you will likely notice symptoms of bleeding problems early, even as a baby. […] Symptoms may include: […] Nosebleeds that happen often and last longer than normal […] Easy bruising […] Bleeding that lasts longer than normal, for example, after a cut, a tooth is pulled or surgery […] For girls, heavy menstrual periods. […] Too much bleeding can be dangerous. But even if your child has a severe type of von Willebrand disease, treatment can help prevent serious problems.

• #42 von Willebrand Disease | Hemophilia Treatment Center | ECU

  https://ecuphysicians.ecu.edu/hemophilia-treatment-center/von-willebrand-disease/

  Many children with mild cases of vWD have no visible symptoms. Others can experience symptoms such as: Frequent large bruises from minor bumps or injuries […] Frequent or prolonged nose bleeds […] Heavy or prolonged menstrual bleeding in females […] Unusually prolonged or heavy bleeding from the gums during teeth cleaning or other dental procedures […] Unusually heavy bleeding after surgery […] Blood in the urine or stool […] Excessive bleeding from minor cuts.

• #43 Von Willebrand disease

  https://www.nhs.uk/conditions/von-willebrand-disease/

  Von Willebrand disease does not always cause symptoms unless you have an injury. Sometimes it’s found when you have more bleeding than usual after surgery or giving birth. […] Symptoms of von Willebrand disease can include: bruising easily, frequent nosebleeds, bleeding gums, bleeding more than usual after an injury or cut, heavy periods. […] Some people also have more severe symptoms, such as: heavy bleeding that’s difficult to stop, for example after an injury or procedure, blood in your poo, blood in your pee (urine), pain, swelling and stiffness in a joint. […] If tests show you have von Willebrand disease, the specialist will tell you which type you have. Types 1 and 2 are the most common and usually cause mild symptoms. Type 3 is rare and causes more severe symptoms. […] If you have type 1 or type 2 and mild symptoms you’ll only need treatment when you get more serious bleeding, or to help prevent bleeding, for example before surgery or dental treatment. […] If you have type 3 or more severe symptoms you may also need regular treatment to help prevent bleeding.

• #44 Von Willebrand disease | Better Health Channel

  https://www.betterhealth.vic.gov.au/health/conditionsandtreatments/von-willebrand-disease

  Most people with VWD have few or no symptoms. The symptoms of VWD vary greatly from person to person. Even members of the same family may have different symptoms. […] The more common symptoms are: having nose bleeds often or that are difficult to stop, easy bruising, very heavy or long menstrual periods, bleeding for a long time with minor cuts, bleeding from the gums, bleeding after injury, surgery or dental work that continues for a long time, heavy or prolonged bleeding after giving birth. […] Less common symptoms that older people might experience are: blood in faeces (poo) from bleeding in the intestines or stomach, blood in urine from bleeding in the kidneys or bladder. […] People with severe forms of VWD, particularly type 3 VWD, may also have other bleeding problems similar to haemophilia, such as: bleeding episodes that are spontaneous or happen for no obvious reason, bleeding into joints and muscles which can cause swelling and pain.

• #45 Von Willebrand Disease | Condition | UT Southwestern Medical Center

  https://utswmed.org/conditions-treatments/von-willebrand-disease/

  Von Willebrand disease, a bleeding disorder that slows down the blood clotting process, affects up to 1% of people in the United States. Many people with this condition bleed for a long time due to injury, surgery, dental care, menstruation, or childbirth. […] Symptoms, which vary depending on the type and severity of the condition, include: Frequent, long-lasting nosebleeds; Bleeding for more than 10 minutes after sustaining a cut or injury; Frequent, easy bruising (bruises are often lumpy); Bleeding heavily after surgery or dental work; Heavy menstrual bleeding; Bleeding heavily following childbirth or miscarriage; Bloody urine or stool. […] People with severe von Willebrand disease may also have spontaneous bleeding episodes (bleeding for no apparent reason) and bleeding in the muscles and joints, resulting in pain and swelling. […] People with mild cases of von Willebrand disease may have no symptoms. Some people don’t realize they have it until they bleed at length following a surgical or dental procedure. […] It’s important to tell a doctor about any symptoms and to seek care if the bleeding does not stop.

• #46 Von Willebrand Disease: Types, Symptoms, Treatments

  https://resources.healthgrades.com/right-care/blood-conditions/von-willebrand-disease

  The main symptom of VWD is bleeding that occurs more easily or is difficult to stop. This can include frequent nosebleeds, easy bruising, or heavy menstrual periods. […] If you have VWD, you may experience prolonged bleeding after an injury. Even a small cut or scrape could lead to bleeding that lasts for more than 10 minutes. […] VWD causes the skin to bruise more easily. These bruises may occur even from a light tap. […] While nosebleeds are generally common, people with VWD experience more frequent and more severe nosebleeds. […] VWD can cause heavy bleeding during menstrual periods, according to the Office on Women’s Health. If you have VWD and you menstruate, you may experience symptoms such as heavy flow that soaks through one tampon or pad every 1–2 hours, passing of blood clots larger in size than a strawberry or grape, and bleeding that lasts more than 7 days. […] People with type 3 VWD may experience internal organ and joint bleeding. […] Type 1 VWD is the most common version of this condition and the least severe. Uncontrollable bleeding associated with more severe forms of VWD can be life threatening.

• #47 Von Willebrand’s disease: Types, symptoms, risk factors, and causes

  https://www.medicalnewstoday.com/articles/188979

  People with the condition will have difficulty forming blood clots. For example, if they cut themselves, it will take longer to stop bleeding. […] Signs and symptoms may be mild and difficult to observe, or they may occur in a range of ways. It is difficult for doctors to diagnose milder forms of von Willebrands disease. […] When symptoms do appear, they tend to include bruising and extended or excessive bleeding. Bleeding might occur around the mucous membranes, including the gastrointestinal tract. […] Symptoms of bleeding include: nosebleeds, which may be prolonged, recurring, or both; bleeding from the gums; longer, heavier menstrual bleeding; excessive bleeding from a cut; excessive bleeding after a tooth extraction or other dental work; bruising, sometimes with lumps forming under the skin. […] In rare and severe cases, the bleeding can damage internal organs. When internal organ damage occurs as a result of this condition, it can be fatal. […] Symptoms may be mild or severe, and they may include nosebleeds, excessive bleeding from a cut, and bruising more easily.

• #48 Von Willebrand Disease: Symptoms, Treatment & Medications | CVS Specialty

  https://www.cvsspecialty.com/resource-center/bleeding-disorders/von-willebrand-disease-vwd-and-hemophilia.html

  Von Willebrand disease (vWD) is the most common inherited bleeding disorder. The signs and symptoms of vWD depend on which type of vWD the person has and how serious it is. Many people who have type 1 vWD have such mild symptoms that they dont know they have it. People who have type 3 vWD may have all of the symptoms listed below, and severe bleeding episodes with no obvious cause. These bleeding episodes can be fatal if not treated right away. The most common symptoms of vWD are: Bruising easily, Increased or prolonged menstrual bleeding, Frequent and prolonged nose bleeds, Blood in stool or urine, Prolonged bleeding after dental work, childbirth, surgery or injury. Early diagnosis of vWD is important to make sure that the patient is treated effectively and can live an active life. […] Early diagnosis of vWD is important to make sure that the patient is treated effectively and can live an active life.

• #49 Symptoms of von Willebrand disease | Hemophilia

  https://www.hemophilia.ca/symptoms-of-von-willebrand-disease/

  Heavy, prolonged menstrual bleeding is the most common symptom for women with VWD. Some women have heavy bleeding throughout the normal menstrual period. This is called menorrhagia. […] If women lose enough blood over a long period, they suffer from iron deficiency anemia. […] Menstrual bleeding can be especially heavy at the time of a girl’s first periods. […] After many years of battling heavy periods, one might expect women with VWD to look forward to menopause. In fact, hormone regulation becomes more chaotic as a woman gets closer to menopause and this increases her risk of unpredictable and heavy bleeding. […] Menorrhagia seriously affects a woman’s quality of life. Here are some examples. Women with menorrhagia caused by VWD may limit the amount of time they work, change careers as a result of bleeding problems, be unable to work normally during their menstrual periods, suffer constant fatigue from iron deficiency anemia, suffer from depression as a result of the strain of their bleeding disorder.

• #50 Von Willebrand Disease – Together by St. Jude™

  https://together.stjude.org/en-us/conditions/blood-disorders/von-willebrand-disease.html

  In addition to mild-to-moderate bleeding, a person with type 3 von Willebrand disease may also have the following: Unexplained episodes of severe bleeding that can be life threatening if not treated right away, Bleeding into joints and muscles, which can cause severe pain and swelling. […] In women, heavy menstrual bleeding is often the main sign of von Willebrand disease. However, a woman with heavy periods does not always have the disorder. […] Von Willebrand disease is most often a mild disorder. Children with milder forms of Von Willebrand disease generally have fewer bleeding symptoms and need less intensive treatment. Those with severe disease may be at higher risk for spontaneous or severe bleeding episodes. […] Complications of von Willebrand disease can include joint bleeds, iron deficiency anemia, or serious bleeding events. It is important to work with your care team to make a treatment and monitoring plan that is right for your child. […] Symptoms of von Willebrand disease include nosebleeds, easy bruising, heavy or abnormal menstrual periods, and longer than normal bleeding after an injury or medical procedure. […] Von Willebrand disease is usually mild, but some people have more severe forms of the disorder.

• #51 Does von Willebrand Disease Make You Tired? | MyHemophiliaTeam

  https://www.myhemophiliateam.com/resources/does-von-willebrand-disease-make-you-tired

  When you live with a bleeding disorder or a clotting disorder like von Willebrand disease (VWD), it can be hard to know if your symptoms are tied to that condition. If youre experiencing fatigue, for example, you may wonder if the disease is behind it. […] Fatigue is one of the most common symptoms of anemia, a condition that can be caused by VWD. Being anemic means that you dont have enough healthy red blood cells in your body. […] When you bleed a lot, your body loses red blood cells, hemoglobin, and iron quickly. If it cant replace what it has lost fast enough, your body wont be able to get oxygen to all your tissues. This can lead to many symptoms, including: Significant tiredness or fatigue. […] Anemia occurs with VWD if you bleed a lot over an extended period of time or regularly lose a lot of blood due to frequent bleeding episodes.

• #52 VWD symptoms

  https://www.haemophilia.org.au/bleeding-disorders/von-willebrand-disease/vwd-symptoms/

  People with severe forms of VWD, particularly type 3 VWD, may also have other bleeding problems similar to haemophilia, such as: Bleeding episodes that are spontaneous or happen for no obvious reason, Bleeding into joints and muscles which can cause swelling and pain, Over time repeated bleeding can damage joints and muscles, causing arthritis and chronic pain. […] The types of symptoms a person with VWD experiences can change over their lifetime. For example, they may have nosebleeds and easy bruising as a child and find this occurs less often as they grow older. However, their type of VWD will not change. […] Women are more likely to show symptoms of VWD than men. Without treatment, women with VWD often bleed more or for longer than normal with menstruation (their period). Some women with VWD also have heavy bleeding a few days or weeks after giving birth and some have a lot of period pain or irregular periods. However, these symptoms are not always related to VWD and may have other causes. An assessment by a gynaecologist is an important part of understanding and treating these symptoms effectively.

• #53 Does von Willebrand Disease Make You Tired? | MyHemophiliaTeam

  https://www.myhemophiliateam.com/resources/does-von-willebrand-disease-make-you-tired

  When you live with a bleeding disorder or a clotting disorder like von Willebrand disease (VWD), it can be hard to know if your symptoms are tied to that condition. If youre experiencing fatigue, for example, you may wonder if the disease is behind it. […] Fatigue is one of the most common symptoms of anemia, a condition that can be caused by VWD. Being anemic means that you dont have enough healthy red blood cells in your body. […] When you bleed a lot, your body loses red blood cells, hemoglobin, and iron quickly. If it cant replace what it has lost fast enough, your body wont be able to get oxygen to all your tissues. This can lead to many symptoms, including: Significant tiredness or fatigue. […] Anemia occurs with VWD if you bleed a lot over an extended period of time or regularly lose a lot of blood due to frequent bleeding episodes.

• #54 Symptoms of von Willebrand disease | Hemophilia

  https://www.hemophilia.ca/symptoms-of-von-willebrand-disease/

  Heavy, prolonged menstrual bleeding is the most common symptom for women with VWD. Some women have heavy bleeding throughout the normal menstrual period. This is called menorrhagia. […] If women lose enough blood over a long period, they suffer from iron deficiency anemia. […] Menstrual bleeding can be especially heavy at the time of a girl’s first periods. […] After many years of battling heavy periods, one might expect women with VWD to look forward to menopause. In fact, hormone regulation becomes more chaotic as a woman gets closer to menopause and this increases her risk of unpredictable and heavy bleeding. […] Menorrhagia seriously affects a woman’s quality of life. Here are some examples. Women with menorrhagia caused by VWD may limit the amount of time they work, change careers as a result of bleeding problems, be unable to work normally during their menstrual periods, suffer constant fatigue from iron deficiency anemia, suffer from depression as a result of the strain of their bleeding disorder.

• #55 Von Willebrand disease // Middlesex Health

  https://middlesexhealth.org/learning-center/diseases-and-conditions/von-willebrand-disease

  Many people with von Willebrand disease don’t know it because the signs are mild or absent. The most common sign of the condition is abnormal bleeding. […] If you have von Willebrand disease, you might have: Excessive bleeding from an injury or after surgery or dental work, Frequent nosebleeds that don’t stop within 10 minutes, Heavy or long menstrual bleeding, Heavy bleeding during labor and delivery, Blood in your urine or stool, Easy bruising or lumpy bruises. […] Menstrual signs and symptoms might include: Blood clots greater than 1 inch (2.5 centimeters) in diameter in your menstrual flow, The need to change your menstrual pad or tampon more than once an hour, The need to use double sanitary protection for menstrual flow, Symptoms of anemia, including tiredness, fatigue or shortness of breath.

• #56 Von Willebrand Disease: Causes, Diagnosis & Treatment | Banner

  https://www.bannerhealth.com/services/pediatrics/diseases-disorders/blood-disease/von-willebrand

  The symptoms of VWD can vary depending on the type and severity. Common signs include: […] In severe cases, bleeding can happen in joints or muscles, which is more serious and painful. […] Females and people assigned female at birth (AFAB) may have: Heavy or long menstrual periods, the need to change a pad or tampon frequently, heavy bleeding during labor and delivery, bleeding between periods (metrorrhagia), symptoms of anemia (iron deficiency), like tiredness, fatigue and shortness of breath.

• #57 Sign up for our newsletter

  https://www.pbi.org.au/vwd-von-willebrand-disease

  The bleeding phenotype (or observable characteristics or traits) in adolescents results in a significant decline in quality of life due to iron deficiency anaemia causing fatigue. Iron deficiency also is associated with reduced cognition in adolescents and girls. A retrospective study found that adolescents presenting with heavy menstrual bleeding (HMB), 50.9% noted to have depression, compared to 24.2% of patients without HMB.

• #58 Von Willebrand disease: MedlinePlus GeneticsLock

  https://medlineplus.gov/genetics/condition/von-willebrand-disease/

  Von Willebrand disease is a bleeding disorder that slows the blood clotting process, causing prolonged bleeding after an injury. People with this condition often experience easy bruising, long-lasting nosebleeds, and excessive bleeding or oozing following an injury, surgery, or dental work. […] In severe cases of von Willebrand disease, heavy bleeding occurs after minor trauma or even in the absence of injury (spontaneous bleeding). Symptoms of von Willebrand disease may change over time. Increased age, pregnancy, exercise, and stress may cause bleeding symptoms to become less frequent. […] People with this condition who have menstrual periods typically have heavy or prolonged bleeding during menstruation (menorrhagia), and some may also experience reproductive tract bleeding during pregnancy and childbirth.

• #59 Von Willebrand disease | Better Health Channel

  https://www.betterhealth.vic.gov.au/health/conditionsandtreatments/von-willebrand-disease

  The types of symptoms a person with VWD experiences can change over their lifetime. For example, they may have nosebleeds and easy bruising as a child and find this occurs less often as they grow older. However, their type of VWD will not change. […] Women are more likely to show symptoms of VWD than men. Without treatment, women with VWD often bleed more or for longer than normal with menstruation (their period). […] Some women with VWD also have heavy bleeding a few days or weeks after giving birth, or pregnancy loss. Some women also have a lot of period pain or irregular periods. However, these symptoms are not always related to VWD and may have other causes. An assessment by a gynaecologist is an important part of understanding and treating these symptoms effectively.

• #60 Von Willebrand Disease | Cigna

  https://www.cigna.com/knowledge-center/hw/medical-topics/von-willebrand-disease-hw183231

  Bleeding a lot is the main symptom of von Willebrand disease. How severe the bleeding is will be different for each person. […] When the disease is mild, symptoms include: Frequent nosebleeds. Some bleeding from the gums. Heavy menstrual periods in women. Bruises that appear for no reason. Heavy bleeding after an injury or surgery. […] When the disease is more severe, you may also have: Blood in the urine. Bruising easily. Black, tarry, or bloody stools. Bleeding into the joints, which causes stiffness, pain, and swelling. This symptom is rare. […] The disease can range from mild to severe. It is mild in most people. It can stay the same or get better or worse as you get older.

• #61 Von Willebrand disease | Better Health Channel

  https://www.betterhealth.vic.gov.au/health/conditionsandtreatments/von-willebrand-disease

  The types of symptoms a person with VWD experiences can change over their lifetime. For example, they may have nosebleeds and easy bruising as a child and find this occurs less often as they grow older. However, their type of VWD will not change. […] Women are more likely to show symptoms of VWD than men. Without treatment, women with VWD often bleed more or for longer than normal with menstruation (their period). […] Some women with VWD also have heavy bleeding a few days or weeks after giving birth, or pregnancy loss. Some women also have a lot of period pain or irregular periods. However, these symptoms are not always related to VWD and may have other causes. An assessment by a gynaecologist is an important part of understanding and treating these symptoms effectively.

• #62 What is von Willebrand Disease?Learn about the most common bleeding disorder

  https://www.siemens-healthineers.com/hemostasis/what-is-von-willebrand-disease

  Frequent nosebleeds may be a symptom of VWD. […] Excessive bleeding from an injury or after surgery or dental work […] Frequent nosebleeds that do not stop within 10 minutes […] Heavy or long menstrual bleeding […] Heavy bleeding during labor and delivery […] Blood in urine or stool […] Easy bruising or lumpy bruises […] Menstrual signs and symptoms of VWD might include: Blood clots greater than 1 inch in diameter in your menstrual flow […] The need to change your menstrual pad or tampon more than once an hour […] The need to use double sanitary protection for menstrual flow […] Symptoms of anemia, including tiredness, fatigue, or shortness of breath. […] A doctor should be consulted when you experience bleeding that lasts a long time or is difficult to stop.

• #63 Von Willebrand Disease | Nationwide Children’s Hospital

  https://www.nationwidechildrens.org/conditions/von-willebrand-disease

  Von Willebrand disease (VWD) is a lifelong bleeding disorder passed down from parents (inherited) through genes. With VWD, bleeding lasts longer than normal because its harder for blood to clot. […] There is no cure for VWD, but there are treatments for some symptoms. […] Nosebleeds that happen often and may be hard to stop. […] Bleeding gums from brushing teeth or flossing. […] Bleeding from injuries, shots (injections), or invasive procedures. […] Heavy menstrual periods. […] Blood in pee (urine) or poop (stool). This is rare. […] Treatment depends on your childs symptoms and the type of VWD they have. […] Call your childs doctor, health care provider, or hematologist if they have: […] Nosebleeds that last more than 15 minutes or happen more often. […] Menstrual periods that are heavier than normal or last more than 7 days, or if theyre passing clots bigger than a quarter. […] Blood in their pee (urine) or poop (stool).

• #64 Von Willebrand Disease | Condition | UT Southwestern Medical Center

  https://utswmed.org/conditions-treatments/von-willebrand-disease/

  Von Willebrand disease, a bleeding disorder that slows down the blood clotting process, affects up to 1% of people in the United States. Many people with this condition bleed for a long time due to injury, surgery, dental care, menstruation, or childbirth. […] Symptoms, which vary depending on the type and severity of the condition, include: Frequent, long-lasting nosebleeds; Bleeding for more than 10 minutes after sustaining a cut or injury; Frequent, easy bruising (bruises are often lumpy); Bleeding heavily after surgery or dental work; Heavy menstrual bleeding; Bleeding heavily following childbirth or miscarriage; Bloody urine or stool. […] People with severe von Willebrand disease may also have spontaneous bleeding episodes (bleeding for no apparent reason) and bleeding in the muscles and joints, resulting in pain and swelling. […] People with mild cases of von Willebrand disease may have no symptoms. Some people don’t realize they have it until they bleed at length following a surgical or dental procedure. […] It’s important to tell a doctor about any symptoms and to seek care if the bleeding does not stop.

• #65 Von Willebrand disease – Diagnosis & treatment – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/von-willebrand-disease/diagnosis-treatment/drc-20354984

  Mild forms of von Willebrand disease can be difficult to diagnose because bleeding is common, and, for most people, doesn’t indicate a disease. […] Your doctor will likely ask you detailed questions about your medical history and check for bruises or other signs of recent bleeding. […] Signs or symptoms that involve bleeding, including how often, how severe and for how long. Include unusual bruising. Your doctor will want to know if you have a history of nosebleeds or easy bruising since childhood. If you menstruate, are your periods extended and heavy? […] Have you had unexpected bruising? Have you ever felt a lump under the bruise? […] If your condition is mild, your doctor might recommend treatment only when you’re having surgery or dental work or when you’ve had a trauma, such as a car accident.

• #66 Von Willebrand Disease | Boston Children’s Hospital

  https://www.childrenshospital.org/conditions/von-willebrand-disease

  Von Willebrand Disease (VWD) symptoms vary depending on the type and severity of the disease and are different for each individual. Many children with VWD have no or minimal symptoms. Others can experience symptoms such as: […] Frequent large bruises from minor bumps or injuries […] Frequent or prolonged nosebleeds […] Heavy or prolonged menstrual bleeding in girls […] Heavy or prolonged bleeding from the gums during teeth cleaning or other dental procedures […] Heavy or prolonged bleeding during or shortly after surgery […] Excessive bleeding from minor cuts. […] It is important to understand that some symptoms of VWD may resemble those of other more common medical problems. Because some of these symptoms can also point to other conditions, it’s important to have your child evaluated by a qualified medical professional for an accurate diagnosis and prompt development of a treatment plan. […] Von Willebrand Disease is a lifelong condition with no cure. The long-term outlook for children with VWD is generally good and most have a normal lifespan. Throughout their lifetime, many patients require periodic treatment for bleeding symptoms or treatment before surgery or dental procedures.

• #67 Von Willebrand Disease | Nationwide Children’s Hospital

  https://www.nationwidechildrens.org/conditions/von-willebrand-disease

  Von Willebrand disease (VWD) is a lifelong bleeding disorder passed down from parents (inherited) through genes. With VWD, bleeding lasts longer than normal because its harder for blood to clot. […] There is no cure for VWD, but there are treatments for some symptoms. […] Nosebleeds that happen often and may be hard to stop. […] Bleeding gums from brushing teeth or flossing. […] Bleeding from injuries, shots (injections), or invasive procedures. […] Heavy menstrual periods. […] Blood in pee (urine) or poop (stool). This is rare. […] Treatment depends on your childs symptoms and the type of VWD they have. […] Call your childs doctor, health care provider, or hematologist if they have: […] Nosebleeds that last more than 15 minutes or happen more often. […] Menstrual periods that are heavier than normal or last more than 7 days, or if theyre passing clots bigger than a quarter. […] Blood in their pee (urine) or poop (stool).

• #68 Von Willebrand Disease: Types, Causes, and Symptoms

  https://www.healthline.com/health/von-willebrand-disease

  If you have von Willebrand disease, your symptoms will vary depending on which type of the disease you have. The most common symptoms that occur in all three types include: […] Type 3 is the most severe form of the condition. If you have this type, you have no VWF in your body. This makes episodes of bleeding difficult to control. It also raises your risk of internal bleeding, including bleeding in your joints and gastrointestinal system. […] Men and women develop von Willebrand disease at the same rate. But women are more likely to experience symptoms and complications due to the increased risk of bleeding during menstruation, pregnancy, and childbirth. […] Most people who have type 1 von Willebrand disease are able to live normal lives with only mild bleeding issues. If you have type 2, you’re at an increased risk of experiencing mild to moderate bleeding and complications. You may experience worse bleeding in the case of infection, surgery, or pregnancy. If you have type 3, you’re at risk of severe bleeding, as well as internal bleeding.

• #69 Orphanet: Von Willebrand disease

  https://www.orpha.net/en/disease/detail/903

  A rare, inherited bleeding disorder characterized by defective platelet adhesion and secondary coagulation defect that manifests as abnormal bleeding of variable severity occurring either spontaneously or in association with an invasive procedure. […] The disease manifests as abnormal bleeding of variable severity occurring either spontaneously or in association with an invasive procedure. The bleeding anomalies are generally characterized by mucocutaneous hemorrhage (epistaxis, menorrhagia, bleeding from minor wounds, etc.) but hematomas and hemarthrosis may occur in more severe forms. […] Age of onset varies, with earlier onset being associated with more severe VWF deficiency. […] For patients managed within specialized hemostasis hospital centers, the prognosis is favorable, even for those with the most severe forms of the disease.

• #70 Von Willebrand Disease – Together by St. Jude™

  https://together.stjude.org/en-us/conditions/blood-disorders/von-willebrand-disease.html

  In addition to mild-to-moderate bleeding, a person with type 3 von Willebrand disease may also have the following: Unexplained episodes of severe bleeding that can be life threatening if not treated right away, Bleeding into joints and muscles, which can cause severe pain and swelling. […] In women, heavy menstrual bleeding is often the main sign of von Willebrand disease. However, a woman with heavy periods does not always have the disorder. […] Von Willebrand disease is most often a mild disorder. Children with milder forms of Von Willebrand disease generally have fewer bleeding symptoms and need less intensive treatment. Those with severe disease may be at higher risk for spontaneous or severe bleeding episodes. […] Complications of von Willebrand disease can include joint bleeds, iron deficiency anemia, or serious bleeding events. It is important to work with your care team to make a treatment and monitoring plan that is right for your child. […] Symptoms of von Willebrand disease include nosebleeds, easy bruising, heavy or abnormal menstrual periods, and longer than normal bleeding after an injury or medical procedure. […] Von Willebrand disease is usually mild, but some people have more severe forms of the disorder.

• #71 Von Willebrand Disease | lahemo

  https://www.lahemo.org/von-willibrands-disease

  Typically, a child bruises easily or has prolonged bleeds excessively after a skin cut, tooth extraction, tonsillectomy, or other surgery. A woman may have increased menstrual bleeding. Bleeding may worsen at times. […] Diagnosis can be difficult. […] The life span of patients is usually normal length. […] Von Willebrand disease can be more complicated for women because of obstetric and gynecological issues.

• #72 Orphanet: Von Willebrand disease

  https://www.orpha.net/en/disease/detail/903

  A rare, inherited bleeding disorder characterized by defective platelet adhesion and secondary coagulation defect that manifests as abnormal bleeding of variable severity occurring either spontaneously or in association with an invasive procedure. […] The disease manifests as abnormal bleeding of variable severity occurring either spontaneously or in association with an invasive procedure. The bleeding anomalies are generally characterized by mucocutaneous hemorrhage (epistaxis, menorrhagia, bleeding from minor wounds, etc.) but hematomas and hemarthrosis may occur in more severe forms. […] Age of onset varies, with earlier onset being associated with more severe VWF deficiency. […] For patients managed within specialized hemostasis hospital centers, the prognosis is favorable, even for those with the most severe forms of the disease.

• #73 Von Willebrand Disease: Symptoms, Treatment & Medications | CVS Specialty

  https://www.cvsspecialty.com/resource-center/bleeding-disorders/von-willebrand-disease-vwd-and-hemophilia.html

  Von Willebrand disease (vWD) is the most common inherited bleeding disorder. The signs and symptoms of vWD depend on which type of vWD the person has and how serious it is. Many people who have type 1 vWD have such mild symptoms that they dont know they have it. People who have type 3 vWD may have all of the symptoms listed below, and severe bleeding episodes with no obvious cause. These bleeding episodes can be fatal if not treated right away. The most common symptoms of vWD are: Bruising easily, Increased or prolonged menstrual bleeding, Frequent and prolonged nose bleeds, Blood in stool or urine, Prolonged bleeding after dental work, childbirth, surgery or injury. Early diagnosis of vWD is important to make sure that the patient is treated effectively and can live an active life. […] Early diagnosis of vWD is important to make sure that the patient is treated effectively and can live an active life.

• #74 Dateline: Ask the CDC – What’s von Willebrand Disease? – Hemophilia Federation of America

  https://www.hemophiliafed.org/dateline-ask-the-cdc-whats-von-willebrand-disease/

  Erik von Willebrand, a Finnish physician, noticed several young girls in one family shared symptoms of a bleeding disorder. […] Von Willebrand disease, or vWD, is a genetic bleeding disorder affecting the blood’s ability to clot. […] Symptoms of vWD often appear first in childhood but the disorder is not always diagnosed until later in life. Bleeding in the nose and mouth, excessive bruising, and bleeding that is difficult to stop after an injury or surgery are all early signs that someone may have vWD. […] Most women and girls with vWD experience heavy periods that can include bleeding for more than seven days, flooding or gushing blood, passing clots larger than a quarter, or having the need to change a pad or tampon every few hours. […] With early diagnosis of vWD, treatment can be given to prevent bleeding and allow any surgical or dental procedure to be done with minimal adverse effects. […] The weakening, fatigue and other disruptive effects of vWD can be stopped. Even childbirth can be made safe for a mother and baby. If you have unexplained bleeding symptoms, remember to ask your doctor, “Could I have von Willebrand disease?”

Zobacz więcej