Materiały źródłowe

• #1

  https://link.springer.com/article/10.1007/s11940-005-0003-5

  Charcot-Marie-Tooth (CMT), or heritable peripheral neuropathies, is among the most frequent genetic neuromuscular disorders, with a prevalence of approximately 1:2500. […] However, these advances have not yet resulted in cures for CMT. Recently, potential treatments for the most common form of CMT, CMT-1A, have been shown in rodent models of the disorder. Treatment with onapristone, a progesterone antagonist, has improved the neuropathy of the CMT-1A rat. Treatment with large doses of ascorbic acid (vitamin C) has improved the neuropathy of the CMT-1A mouse. Multicentric trials with ascorbic acid are likely to start in the near future to assess if vitamin C supplementation is effective and what is the dosage required in humans to improve neurologic disability. […] Although no cures are available for CMT, there are many important treatments available for patients with CMT that can improve their quality of life and help them maintain their independence. Some of these therapies involve physiatry and orthopedic surgery. Others involve pain management. Lastly, there are potential concerns about medications or lifestyle issues that may exacerbate CMT. All of these issues will be discussed.

• #2 Charcot-Marie-Tooth disease | Beacon Health System

  https://www.beaconhealthsystem.org/library/diseases-and-conditions/charcot-marie-tooth-disease?content_id=CON-20155112

  There’s no cure for Charcot-Marie-Tooth disease. But the disease generally progresses slowly, and it doesn’t affect expected life span. […] There are some treatments to help you manage Charcot-Marie-Tooth disease. […] Charcot-Marie-Tooth disease may sometimes cause pain due to muscle cramps or nerve damage. If pain is an issue for you, prescription pain medication may help control your pain. […] Physical therapy can help strengthen and stretch your muscles to prevent muscle tightening and loss. A program usually includes low-impact exercises and stretching techniques guided by a trained physical therapist and approved by your doctor. Started early and followed regularly, physical therapy can help prevent disability. […] Occupational therapy can help through the use of assistive devices, such as special rubber grips on doorknobs, or clothing with snaps instead of buttons.

• #3 Medications and Charcot-Marie-Tooth Disease | Charcot–Marie–Tooth Association

  https://www.cmtausa.org/living-with-cmt/managing-cmt/medications/

  There currently are no available treatments that act to slow the progression of Charcot-Marie-Tooth disease. […] However, there are medications that doctors may prescribe to you to help treat the symptoms of CMT rather than the disease itself. […] Medications can play a crucial role in helping you cope with the symptoms and improve your quality of life. […] On this page, you will find information about a variety of medication types that a person with CMT may be prescribed for managing symptoms or comorbid diseases. […] CMT often causes chronic, neuropathic pain that makes day-to-day life with Charcot-Marie-Tooth disease more difficult. If neuropathy is causing pain that diminishes quality of life, then this symptom should be treated. […] The risk is minimal if the drugs are indicated. Some of these agents have been studied as treatments for neuropathic pain and showed no signs of making patients worse.

• #4 Charcot-Marie-Tooth disease | Beacon Health System

  https://www.beaconhealthsystem.org/library/diseases-and-conditions/charcot-marie-tooth-disease?content_id=CON-20155112

  There’s no cure for Charcot-Marie-Tooth disease. But the disease generally progresses slowly, and it doesn’t affect expected life span. […] There are some treatments to help you manage Charcot-Marie-Tooth disease. […] Charcot-Marie-Tooth disease may sometimes cause pain due to muscle cramps or nerve damage. If pain is an issue for you, prescription pain medication may help control your pain. […] Physical therapy can help strengthen and stretch your muscles to prevent muscle tightening and loss. A program usually includes low-impact exercises and stretching techniques guided by a trained physical therapist and approved by your doctor. Started early and followed regularly, physical therapy can help prevent disability. […] Occupational therapy can help through the use of assistive devices, such as special rubber grips on doorknobs, or clothing with snaps instead of buttons.

• #5 Current Treatment Methods for Charcot–Marie–Tooth Diseases

  https://pmc.ncbi.nlm.nih.gov/articles/PMC11430469/

  CharcotMarieTooth (CMT) disease, the most common inherited neuromuscular disorder, exhibits a wide phenotypic range, genetic heterogeneity, and a variable disease course. Currently, there are no approved disease management methods that can fully cure patients with CMT, and rehabilitation, orthotics, and surgery are the only available treatments to ameliorate symptoms. Considerable research attention has been given to disease-modifying therapies, including gene silencing, gene addition, and gene editing, but most treatments that reach clinical trials are drug treatments, while currently, only gene therapies for CMT2S have reached the clinical trial stage. […] Exercise has been identified as an effective treatment strategy for people in the early stages of CMT. To prevent disease progression, rehabilitation interventions including muscle strengthening, stretching, aerobic conditioning, and proprioceptive exercises are recommended.

• #6 Charcot-Marie-Tooth Disease | National Institute of Neurological Disorders and Stroke

  https://www.ninds.nih.gov/health-information/disorders/charcot-marie-tooth-disease

  There is no cure for CMT. Treatments such as physical therapy, orthopedic devices (such as braces), surgery, and medication prescribed by a doctor can help manage symptoms […] It is important to maintain mobility, flexibility, and muscle strength as much as possible. Starting a treatment program soon after symptoms begin can help people maintain quality of life. Physical and occupational therapy, braces and other orthopedic devices, and orthopedic surgery may help with symptoms of CMT. In addition, doctors may prescribe medication for severe nerve pain. […] High-top shoes or boots can support weak ankles, while thumb splints can help with hand weakness and fine motor skills (using small hand muscles to do things). Using assistive devices like these early on (before disability sets in) may prevent muscle strain and reduce muscle weakening.

• #7 Medical Management – Charcot-Marie-Tooth Disease (CMT) – Diseases | Muscular Dystrophy AssociationMapHeartMapSearchSearchFacebookLinkedInTwitterYouTubeInstagramFacebookLinkedInTwitterYouTubeInstagram

  https://www.mda.org/disease/charcot-marie-tooth/medical-management

  Management of CMT is currently supportive; however, such supportive therapy can dramatically improve a patient’s quality of life. Although there is no cure for CMT, there are treatments that can be used to effectively manage its symptoms. These treatments have allowed many people with the disease to lead active, productive lives. The main treatment for CMT involves working with an occupational or physical therapist. Optimal management is multidisciplinary, with care provided by neurologists, genetic counselors, nurses, physical and occupational therapists, physiatrists, and orthopedic surgeons. […] Late in the course of CMT, many people experience weakness in the hands and forearms and have difficulty with gripping and fine finger movements, such as turning doorknobs and buttoning and zippering clothes. Often, these problems can be overcome with occupational therapy, which helps people accomplish tasks of daily living with the use of assistive devices.

• #8 Charcot-Marie-Tooth disease: Management and prognosis – UpToDate

  https://www.uptodate.com/contents/charcot-marie-tooth-disease-management-and-prognosis

  Charcot-Marie-Tooth disease (CMT) is a group of hereditary neuropathies characterized by progressive motor and sensory nerve dysfunction, including a characteristic atrophy of calf muscles in several subtypes. CMT is the most common hereditary peripheral neuropathy. It is caused by one of several pathogenic variants in genes whose protein products are expressed in myelin, gap junctions, and/or axonal structures within peripheral nerves. […] Management of CMT is currently supportive; however, such supportive therapy can dramatically improve a patient’s quality of life. Specific disease-modifying therapies are not available. Several agents are under active investigation in clinical trials. Optimal management is multidisciplinary, with care provided by neurologists, genetic counselors, nurses, physical and occupational therapists, physiatrists, and orthopedic surgeons.

• #9 Charcot-Marie-Tooth Disease | National Institute of Neurological Disorders and Stroke

  https://www.ninds.nih.gov/health-information/disorders/charcot-marie-tooth-disease

  There is no cure for CMT. Treatments such as physical therapy, orthopedic devices (such as braces), surgery, and medication prescribed by a doctor can help manage symptoms […] It is important to maintain mobility, flexibility, and muscle strength as much as possible. Starting a treatment program soon after symptoms begin can help people maintain quality of life. Physical and occupational therapy, braces and other orthopedic devices, and orthopedic surgery may help with symptoms of CMT. In addition, doctors may prescribe medication for severe nerve pain. […] High-top shoes or boots can support weak ankles, while thumb splints can help with hand weakness and fine motor skills (using small hand muscles to do things). Using assistive devices like these early on (before disability sets in) may prevent muscle strain and reduce muscle weakening.

• #10 Medical Management – Charcot-Marie-Tooth Disease (CMT) – Diseases | Muscular Dystrophy AssociationMapHeartMapSearchSearchFacebookLinkedInTwitterYouTubeInstagramFacebookLinkedInTwitterYouTubeInstagram

  https://www.mda.org/disease/charcot-marie-tooth/medical-management

  Many people with CMT make their first visit to a neurologist after they notice frequent trips and falls, ankle sprains, or ankle fractures, all caused by foot drop. When these problems occur, some people find they can overcome them by wearing boots or high-top shoes to support the ankles. Others might require leg braces, such as an ankle-foot orthosis (AFO), a removable frame that fits snugly around the foot and ankle. […] One of the most effective ways to keep muscles from tightening up and forming contractures is to begin a regular program of physical therapy, which usually consists of low-impact exercises and stretching. […] Your MDA Care Center can help get you started on an individualized physical therapy program.

• #11 Charcot-Marie-Tooth disease | Beacon Health System

  https://www.beaconhealthsystem.org/library/diseases-and-conditions/charcot-marie-tooth-disease?content_id=CON-20155112

  There’s no cure for Charcot-Marie-Tooth disease. But the disease generally progresses slowly, and it doesn’t affect expected life span. […] There are some treatments to help you manage Charcot-Marie-Tooth disease. […] Charcot-Marie-Tooth disease may sometimes cause pain due to muscle cramps or nerve damage. If pain is an issue for you, prescription pain medication may help control your pain. […] Physical therapy can help strengthen and stretch your muscles to prevent muscle tightening and loss. A program usually includes low-impact exercises and stretching techniques guided by a trained physical therapist and approved by your doctor. Started early and followed regularly, physical therapy can help prevent disability. […] Occupational therapy can help through the use of assistive devices, such as special rubber grips on doorknobs, or clothing with snaps instead of buttons.

• #12 Charcot-Marie-Tooth Disease | National Institute of Neurological Disorders and Stroke

  https://www.ninds.nih.gov/health-information/disorders/charcot-marie-tooth-disease

  There is no cure for CMT. Treatments such as physical therapy, orthopedic devices (such as braces), surgery, and medication prescribed by a doctor can help manage symptoms […] It is important to maintain mobility, flexibility, and muscle strength as much as possible. Starting a treatment program soon after symptoms begin can help people maintain quality of life. Physical and occupational therapy, braces and other orthopedic devices, and orthopedic surgery may help with symptoms of CMT. In addition, doctors may prescribe medication for severe nerve pain. […] High-top shoes or boots can support weak ankles, while thumb splints can help with hand weakness and fine motor skills (using small hand muscles to do things). Using assistive devices like these early on (before disability sets in) may prevent muscle strain and reduce muscle weakening.

• #13 Current Treatment Methods for Charcot–Marie–Tooth Diseases

  https://pmc.ncbi.nlm.nih.gov/articles/PMC11430469/

  CharcotMarieTooth (CMT) disease, the most common inherited neuromuscular disorder, exhibits a wide phenotypic range, genetic heterogeneity, and a variable disease course. Currently, there are no approved disease management methods that can fully cure patients with CMT, and rehabilitation, orthotics, and surgery are the only available treatments to ameliorate symptoms. Considerable research attention has been given to disease-modifying therapies, including gene silencing, gene addition, and gene editing, but most treatments that reach clinical trials are drug treatments, while currently, only gene therapies for CMT2S have reached the clinical trial stage. […] Exercise has been identified as an effective treatment strategy for people in the early stages of CMT. To prevent disease progression, rehabilitation interventions including muscle strengthening, stretching, aerobic conditioning, and proprioceptive exercises are recommended.

• #14 Current Treatment Methods for Charcot–Marie–Tooth Diseases

  https://pmc.ncbi.nlm.nih.gov/articles/PMC11430469/

  CharcotMarieTooth (CMT) disease, the most common inherited neuromuscular disorder, exhibits a wide phenotypic range, genetic heterogeneity, and a variable disease course. Currently, there are no approved disease management methods that can fully cure patients with CMT, and rehabilitation, orthotics, and surgery are the only available treatments to ameliorate symptoms. Considerable research attention has been given to disease-modifying therapies, including gene silencing, gene addition, and gene editing, but most treatments that reach clinical trials are drug treatments, while currently, only gene therapies for CMT2S have reached the clinical trial stage. […] Exercise has been identified as an effective treatment strategy for people in the early stages of CMT. To prevent disease progression, rehabilitation interventions including muscle strengthening, stretching, aerobic conditioning, and proprioceptive exercises are recommended.

• #15 Current Treatment Methods for Charcot–Marie–Tooth Diseases

  https://www.mdpi.com/2218-273X/14/9/1138

  Charcot–Marie–Tooth (CMT) disease, the most common inherited neuromuscular disorder, exhibits a wide phenotypic range, genetic heterogeneity, and a variable disease course. […] Currently, there are no approved disease management methods that can fully cure patients with CMT, and rehabilitation, orthotics, and surgery are the only available treatments to ameliorate symptoms. […] Considerable research attention has been given to disease-modifying therapies, including gene silencing, gene addition, and gene editing, but most treatments that reach clinical trials are drug treatments, while currently, only gene therapies for CMT2S have reached the clinical trial stage. […] Exercise has been identified as an effective treatment strategy for people in the early stages of CMT. […] To prevent disease progression, rehabilitation interventions including muscle strengthening, stretching, aerobic conditioning, and proprioceptive exercises are recommended.

• #16 Charcot-Marie-Tooth disease: Management and prognosis – UpToDate

  https://www.uptodate.com/contents/charcot-marie-tooth-disease-management-and-prognosis

  A comprehensive rehabilitation program plays a crucial role in the management of individuals affected by CMT. All patients should be evaluated for weakness (both distal and proximal), joint contractures, physical conditioning, ambulation, balance, coordination, and manual dexterity. A major goal is the prevention of complications such as joint deformity and falls. Daily stretching exercises early in the course of the disease may help delay ankle contractures. Moderate quality evidence suggests progressive resistance exercise programs may improve functional outcomes. Occupational therapy can help to improve function with activities of daily living. An intensive rehabilitation regimen demonstrated benefit in one study, but the therapeutic effects attenuated after cessation of the program. […] Orthotics, including ankle-foot orthoses, are often used to help stabilize the ankles and enhance gait function. Tolerability and response to orthotics should be monitored to optimize compliance. Orthopedic foot surgery may be beneficial for severe manifestations of contractures, pes cavus deformity, and hammer toes, typically during adolescence or early adulthood.

• #17 Charcot-Marie-Tooth disease: Management and prognosis – UpToDate

  https://www.uptodate.com/contents/charcot-marie-tooth-disease-management-and-prognosis

  A comprehensive rehabilitation program plays a crucial role in the management of individuals affected by CMT. All patients should be evaluated for weakness (both distal and proximal), joint contractures, physical conditioning, ambulation, balance, coordination, and manual dexterity. A major goal is the prevention of complications such as joint deformity and falls. Daily stretching exercises early in the course of the disease may help delay ankle contractures. Moderate quality evidence suggests progressive resistance exercise programs may improve functional outcomes. Occupational therapy can help to improve function with activities of daily living. An intensive rehabilitation regimen demonstrated benefit in one study, but the therapeutic effects attenuated after cessation of the program. […] Orthotics, including ankle-foot orthoses, are often used to help stabilize the ankles and enhance gait function. Tolerability and response to orthotics should be monitored to optimize compliance. Orthopedic foot surgery may be beneficial for severe manifestations of contractures, pes cavus deformity, and hammer toes, typically during adolescence or early adulthood.

• #18 First effective treatment of children with Charcot-Marie-Tooth disease – The University of Sydney

  https://www.sydney.edu.au/news-opinion/news/2017/07/17/first-effective-treatment-of-children-with-charcot-marie-tooth-d.html

  Exercise is the best medicine for Charcot-Marie-Tooth disease. […] A new research study from the University of Sydney has found that for children with Charcot-Marie-Tooth disease, the most effective way to treat their condition is with exercise. […] The study found that progressive resistance exercise could help to significantly reduce the muscle weakness experienced by patients with the genetic disease. […] Published in The Lancet Child Adolescent Health, the study showed that six months of moderate-intensity progressive resistance exercise could help not only slow the progression of muscle weakness by up to 30 per cent compared to CMT patients who did not exercise, but also strengthened their muscles over a two-year period. […] For patients with CMT, the results of this trial are life-changing, helping to not only improve their chronic pain and reduce the degree of disability, but also greatly helping to improve their quality of life. […] Exercise is an important bridging therapy for children and adults in the meantime. […] However, given the trials success, similar targeted exercises can now also be applied to other affected muscles in the body in a safe and effective way.

• #19 Charcot-Marie-Tooth disease (CMT) – Muscular Dystrophy UK

  https://www.musculardystrophyuk.org/conditions/a-z/charcot-marie-tooth-disease-cmt/

  A multi-disciplinary approach, which involves different healthcare professionals working together, is important in not only managing the condition and symptoms but in improving wellbeing too. […] People with CMT should have access to a multi-disciplinary healthcare team, usually led by a neurologist. If you’re not in contact with a neurologist, speak to your GP about getting access to one. […] Mild exercise can help improve balance and maintain strength, and stretching can improve flexibility. A physiotherapist, a healthcare professional who helps manage symptoms through movement, exercise, and manual therapy, can put together a suitable exercise plan. Regular heel-stretching exercises are recommended to prevent muscle tightening and shortening. Low-impact aerobic exercises, such as swimming and walking, are recommended for all neuromuscular conditions.

• #20 Charcot-Marie-Tooth disease | Beacon Health System

  https://www.beaconhealthsystem.org/library/diseases-and-conditions/charcot-marie-tooth-disease?content_id=CON-20155112

  There’s no cure for Charcot-Marie-Tooth disease. But the disease generally progresses slowly, and it doesn’t affect expected life span. […] There are some treatments to help you manage Charcot-Marie-Tooth disease. […] Charcot-Marie-Tooth disease may sometimes cause pain due to muscle cramps or nerve damage. If pain is an issue for you, prescription pain medication may help control your pain. […] Physical therapy can help strengthen and stretch your muscles to prevent muscle tightening and loss. A program usually includes low-impact exercises and stretching techniques guided by a trained physical therapist and approved by your doctor. Started early and followed regularly, physical therapy can help prevent disability. […] Occupational therapy can help through the use of assistive devices, such as special rubber grips on doorknobs, or clothing with snaps instead of buttons.

• #21 Charcot-Marie-Tooth disease | Beacon Health System

  https://www.beaconhealthsystem.org/library/diseases-and-conditions/charcot-marie-tooth-disease?content_id=CON-20155112

  There’s no cure for Charcot-Marie-Tooth disease. But the disease generally progresses slowly, and it doesn’t affect expected life span. […] There are some treatments to help you manage Charcot-Marie-Tooth disease. […] Charcot-Marie-Tooth disease may sometimes cause pain due to muscle cramps or nerve damage. If pain is an issue for you, prescription pain medication may help control your pain. […] Physical therapy can help strengthen and stretch your muscles to prevent muscle tightening and loss. A program usually includes low-impact exercises and stretching techniques guided by a trained physical therapist and approved by your doctor. Started early and followed regularly, physical therapy can help prevent disability. […] Occupational therapy can help through the use of assistive devices, such as special rubber grips on doorknobs, or clothing with snaps instead of buttons.

• #22 Medical Management – Charcot-Marie-Tooth Disease (CMT) – Diseases | Muscular Dystrophy AssociationMapHeartMapSearchSearchFacebookLinkedInTwitterYouTubeInstagramFacebookLinkedInTwitterYouTubeInstagram

  https://www.mda.org/disease/charcot-marie-tooth/medical-management

  Management of CMT is currently supportive; however, such supportive therapy can dramatically improve a patient’s quality of life. Although there is no cure for CMT, there are treatments that can be used to effectively manage its symptoms. These treatments have allowed many people with the disease to lead active, productive lives. The main treatment for CMT involves working with an occupational or physical therapist. Optimal management is multidisciplinary, with care provided by neurologists, genetic counselors, nurses, physical and occupational therapists, physiatrists, and orthopedic surgeons. […] Late in the course of CMT, many people experience weakness in the hands and forearms and have difficulty with gripping and fine finger movements, such as turning doorknobs and buttoning and zippering clothes. Often, these problems can be overcome with occupational therapy, which helps people accomplish tasks of daily living with the use of assistive devices.

• #23 Charcot-Marie-Tooth disease | Beacon Health System

  https://www.beaconhealthsystem.org/library/diseases-and-conditions/charcot-marie-tooth-disease?content_id=CON-20155112

  There’s no cure for Charcot-Marie-Tooth disease. But the disease generally progresses slowly, and it doesn’t affect expected life span. […] There are some treatments to help you manage Charcot-Marie-Tooth disease. […] Charcot-Marie-Tooth disease may sometimes cause pain due to muscle cramps or nerve damage. If pain is an issue for you, prescription pain medication may help control your pain. […] Physical therapy can help strengthen and stretch your muscles to prevent muscle tightening and loss. A program usually includes low-impact exercises and stretching techniques guided by a trained physical therapist and approved by your doctor. Started early and followed regularly, physical therapy can help prevent disability. […] Occupational therapy can help through the use of assistive devices, such as special rubber grips on doorknobs, or clothing with snaps instead of buttons.

• #24 Charcot-Marie-Tooth disease | Beacon Health System

  https://www.beaconhealthsystem.org/library/diseases-and-conditions/charcot-marie-tooth-disease?content_id=CON-20155112

  There’s no cure for Charcot-Marie-Tooth disease. But the disease generally progresses slowly, and it doesn’t affect expected life span. […] There are some treatments to help you manage Charcot-Marie-Tooth disease. […] Charcot-Marie-Tooth disease may sometimes cause pain due to muscle cramps or nerve damage. If pain is an issue for you, prescription pain medication may help control your pain. […] Physical therapy can help strengthen and stretch your muscles to prevent muscle tightening and loss. A program usually includes low-impact exercises and stretching techniques guided by a trained physical therapist and approved by your doctor. Started early and followed regularly, physical therapy can help prevent disability. […] Occupational therapy can help through the use of assistive devices, such as special rubber grips on doorknobs, or clothing with snaps instead of buttons.

• #25 Charcot-Marie-Tooth Disease | Saint Luke’s Health System

  https://www.saintlukeskc.org/health-library/charcot-marie-tooth-disease

  How is Charcot-Marie-Tooth disease treated? There is no cure for CMT. But these treatments can help: […] Physical therapy to strengthen and stretch your muscles. This may help prevent or delay disability caused by weakness and deformity. […] Occupational therapy to help with your daily activities. This includes using special devices like rubber grips, or changing from buttons and zippers to Velcro. […] Orthopedic devices, such as ankle braces, high-top boots, and thumb splints. […] Pain medicines if needed. […] Surgery for severe deformities of the feet, spine, or other joints. […] Charcot-Marie-Tooth can’t be cured at this time. But treatments, such as physical and occupational therapy, can often be very helpful. Most people with this condition live to a normal age and remain active.

• #26 Effective Charcot Marie Tooth Disease Treatment

  https://drchandrilchugh.com/charcot-marie-tooth-disease/effective-charcot-marie-tooth-disease-treatments/

  Physical and occupational therapy play a crucial role in the comprehensive treatment plan for individuals with Charcot Marie Tooth Disease. These therapies focus on improving mobility, preventing disability, and enhancing overall quality of life. Through targeted exercises, muscle strengthening, and adaptive techniques, physical and occupational therapy can help individuals with CMT manage their symptoms effectively. […] Occupational therapy focuses on helping individuals overcome challenges with everyday tasks and activities. It aims to improve independence and quality of life by teaching adaptive techniques and providing assistive devices if necessary. […] In addition to current therapy options, ongoing research offers hope for potential future treatments for Charcot Marie Tooth Disease.

• #27

  https://journals.lww.com/md-journal/fulltext/2016/04260/rehabilitation_management_of_the.5.aspx

  The evidence provided concerned 2 aspects of CMT rehabilitation: physiotherapy and orthotic treatment. […] The results show that splinting significantly increases functionality in daily activities as well as occupational performance. […] Orthosis role in CMT management has to be further studied: isolated data showed it as associated with a significant improvement of the ROM in the ankle dorsiflexion, thus allowing a better walking kinematic. These conclusions, however, cannot be considered evidence based. Also hand orthosis must be studied and tested more in depth, as just 1 RCT showed its benefits.

• #28 Charcot-Marie-Tooth Disease – OrthoInfo – AAOS

  https://orthoinfo.aaos.org/en/diseases–conditions/charcot-marie-tooth-disease/

  Assistive devices. Braces, such as ankle-foot orthoses (AFOs), can support the feet in proper position and address gait problems, such as foot drop. Custom-made shoes and shoe inserts can help to fit high arches or hammertoes. […] Occupational therapy. Over time, people with CMT may develop hand and arm weakness. Typical daily activities, such as fastening buttons or writing, can become difficult. An occupational therapist can: Provide a program to help you or your child maintain fine finger movements, Offer assistive tools to help you or your child accomplish daily activities. […] Foot care. Sensory loss in the feet can allow small blisters or sores to progress to a serious infection in a short time. Inspect your or your child’s feet daily for any problems. Choose well-fitting shoes. See a podiatrist to remove calluses that may develop due to foot deformities.

• #29 Charcot-Marie-Tooth Disease | Conditions | UCSF Benioff Children’s Hospitals

  https://www.ucsfbenioffchildrens.org/conditions/charcot-marie-tooth-disease

  Although there is currently no cure for CMT, there are treatments available to help manage its complications and improve patients’ quality of life. Therapies may include physical therapy, occupational therapy, braces and other mobility devices, as well as orthopedic surgery. […] Physical and occupational therapy is an essential part of CMT therapy. This may involve muscle strength and stamina training, muscle and ligament stretching and moderate aerobic exercise. The goal is to preserve function and maintain comfort. […] Mobility devices may increase a person’s ability to move, provide support and decrease the risk of injuries. Many people with CMT develop foot deformities that may be corrected with braces. […] If a foot deformity prevents the foot from being manipulated into proper alignment with a brace, surgery may help. The goal of surgery is to help the foot and leg function as normally as possible, so the patient can walk with minimal difficulty.

• #30 Charcot-Marie-Tooth disease | Beacon Health System

  https://www.beaconhealthsystem.org/library/diseases-and-conditions/charcot-marie-tooth-disease?content_id=CON-20155112

  Many people with Charcot-Marie-Tooth disease require the help of certain orthopedic devices to maintain everyday mobility and to prevent injury. Leg and ankle braces or splints can provide stability while walking and climbing stairs. […] If foot deformities are severe, corrective foot surgery may help alleviate pain and improve your ability to walk. Surgery can’t improve weakness or loss of sensation. […] Researchers are investigating a number of potential therapies that may one day treat Charcot-Marie-Tooth disease. Potential therapies include medications, gene therapy and in vitro procedures that may help prevent passing the disease to future generations.

• #31 Charcot-Marie-Tooth Disease | National Institute of Neurological Disorders and Stroke

  https://www.ninds.nih.gov/health-information/disorders/charcot-marie-tooth-disease

  There is no cure for CMT. Treatments such as physical therapy, orthopedic devices (such as braces), surgery, and medication prescribed by a doctor can help manage symptoms […] It is important to maintain mobility, flexibility, and muscle strength as much as possible. Starting a treatment program soon after symptoms begin can help people maintain quality of life. Physical and occupational therapy, braces and other orthopedic devices, and orthopedic surgery may help with symptoms of CMT. In addition, doctors may prescribe medication for severe nerve pain. […] High-top shoes or boots can support weak ankles, while thumb splints can help with hand weakness and fine motor skills (using small hand muscles to do things). Using assistive devices like these early on (before disability sets in) may prevent muscle strain and reduce muscle weakening.

• #32 Charcot-Marie-Tooth Disease | National Institute of Neurological Disorders and Stroke

  https://www.ninds.nih.gov/health-information/disorders/charcot-marie-tooth-disease

  There is no cure for CMT. Treatments such as physical therapy, orthopedic devices (such as braces), surgery, and medication prescribed by a doctor can help manage symptoms […] It is important to maintain mobility, flexibility, and muscle strength as much as possible. Starting a treatment program soon after symptoms begin can help people maintain quality of life. Physical and occupational therapy, braces and other orthopedic devices, and orthopedic surgery may help with symptoms of CMT. In addition, doctors may prescribe medication for severe nerve pain. […] High-top shoes or boots can support weak ankles, while thumb splints can help with hand weakness and fine motor skills (using small hand muscles to do things). Using assistive devices like these early on (before disability sets in) may prevent muscle strain and reduce muscle weakening.

• #33 Current Treatment Methods for Charcot–Marie–Tooth Diseases

  https://pmc.ncbi.nlm.nih.gov/articles/PMC11430469/

  Orthoses is another CMT management method that complements rehabilitative approaches and plays an important role in improving balance, gait, and the ability to perform the activities of daily life. […] As physiotherapy, proper foot care, and surgery are not enough to ameliorate CMT-related symptoms, additional symptomatological drugs are used. […] Drug treatment for CMT primarily focuses on symptom relief, whereas gene therapy aims to ameliorate or potentially cure symptoms of CMT with minimal adverse events by transferring genetic material into the cells of the patients. […] Gene therapy is the treatment of a disease through transferring genetic material into cells of the patients. Gene addition and gene replacement are important methods for gene therapies. […] Current gene editing technology is laying the foundation for the formulation of future disease therapies.

• #34 Current Treatment Methods for Charcot–Marie–Tooth Diseases

  https://www.mdpi.com/2218-273X/14/9/1138

  Orthoses is another CMT management method that complements rehabilitative approaches and plays an important role in improving balance, gait, and the ability to perform the activities of daily life. […] As the disease progresses, orthotic foot wear may be required to slow down the development of deformities, supporting against foot drop, stabilizing gait, and reducing pain or sores. […] Over time, the deformities of CMT patients tend to progress in severity. […] In the early stages of the condition, flexible deformities including equines, cavus, or forefoot valgus and hindfoot varus can be corrected by joint-sparing osteotomies, soft-tissue release, and tendon transfers, with elaborate preoperative evaluation and individualized plans. […] As physiotherapy, proper foot care, and surgery are not enough to ameliorate CMT-related symptoms, additional symptomatological drugs are used.

• #35 Current Treatment Methods for Charcot–Marie–Tooth Diseases

  https://www.mdpi.com/2218-273X/14/9/1138

  Orthoses is another CMT management method that complements rehabilitative approaches and plays an important role in improving balance, gait, and the ability to perform the activities of daily life. […] As the disease progresses, orthotic foot wear may be required to slow down the development of deformities, supporting against foot drop, stabilizing gait, and reducing pain or sores. […] Over time, the deformities of CMT patients tend to progress in severity. […] In the early stages of the condition, flexible deformities including equines, cavus, or forefoot valgus and hindfoot varus can be corrected by joint-sparing osteotomies, soft-tissue release, and tendon transfers, with elaborate preoperative evaluation and individualized plans. […] As physiotherapy, proper foot care, and surgery are not enough to ameliorate CMT-related symptoms, additional symptomatological drugs are used.

• #36 Charcot-Marie-Tooth disease | Beacon Health System

  https://www.beaconhealthsystem.org/library/diseases-and-conditions/charcot-marie-tooth-disease?content_id=CON-20155112

  Many people with Charcot-Marie-Tooth disease require the help of certain orthopedic devices to maintain everyday mobility and to prevent injury. Leg and ankle braces or splints can provide stability while walking and climbing stairs. […] If foot deformities are severe, corrective foot surgery may help alleviate pain and improve your ability to walk. Surgery can’t improve weakness or loss of sensation. […] Researchers are investigating a number of potential therapies that may one day treat Charcot-Marie-Tooth disease. Potential therapies include medications, gene therapy and in vitro procedures that may help prevent passing the disease to future generations.

• #37 Medical Management – Charcot-Marie-Tooth Disease (CMT) – Diseases | Muscular Dystrophy AssociationMapHeartMapSearchSearchFacebookLinkedInTwitterYouTubeInstagramFacebookLinkedInTwitterYouTubeInstagram

  https://www.mda.org/disease/charcot-marie-tooth/medical-management

  Many people with CMT make their first visit to a neurologist after they notice frequent trips and falls, ankle sprains, or ankle fractures, all caused by foot drop. When these problems occur, some people find they can overcome them by wearing boots or high-top shoes to support the ankles. Others might require leg braces, such as an ankle-foot orthosis (AFO), a removable frame that fits snugly around the foot and ankle. […] One of the most effective ways to keep muscles from tightening up and forming contractures is to begin a regular program of physical therapy, which usually consists of low-impact exercises and stretching. […] Your MDA Care Center can help get you started on an individualized physical therapy program.

• #38 Medical Management – Charcot-Marie-Tooth Disease (CMT) – Diseases | Muscular Dystrophy AssociationMapHeartMapSearchSearchFacebookLinkedInTwitterYouTubeInstagramFacebookLinkedInTwitterYouTubeInstagram

  https://www.mda.org/disease/charcot-marie-tooth/medical-management

  Many people with CMT make their first visit to a neurologist after they notice frequent trips and falls, ankle sprains, or ankle fractures, all caused by foot drop. When these problems occur, some people find they can overcome them by wearing boots or high-top shoes to support the ankles. Others might require leg braces, such as an ankle-foot orthosis (AFO), a removable frame that fits snugly around the foot and ankle. […] One of the most effective ways to keep muscles from tightening up and forming contractures is to begin a regular program of physical therapy, which usually consists of low-impact exercises and stretching. […] Your MDA Care Center can help get you started on an individualized physical therapy program.

• #39

  https://journals.lww.com/md-journal/fulltext/2016/04260/rehabilitation_management_of_the.5.aspx

  The evidence provided concerned 2 aspects of CMT rehabilitation: physiotherapy and orthotic treatment. […] The results show that splinting significantly increases functionality in daily activities as well as occupational performance. […] Orthosis role in CMT management has to be further studied: isolated data showed it as associated with a significant improvement of the ROM in the ankle dorsiflexion, thus allowing a better walking kinematic. These conclusions, however, cannot be considered evidence based. Also hand orthosis must be studied and tested more in depth, as just 1 RCT showed its benefits.

• #40

  https://journals.lww.com/md-journal/fulltext/2016/04260/rehabilitation_management_of_the.5.aspx

  The evidence provided concerned 2 aspects of CMT rehabilitation: physiotherapy and orthotic treatment. […] The results show that splinting significantly increases functionality in daily activities as well as occupational performance. […] Orthosis role in CMT management has to be further studied: isolated data showed it as associated with a significant improvement of the ROM in the ankle dorsiflexion, thus allowing a better walking kinematic. These conclusions, however, cannot be considered evidence based. Also hand orthosis must be studied and tested more in depth, as just 1 RCT showed its benefits.

• #41 Charcot-Marie-Tooth disease | healthdirect

  https://www.healthdirect.gov.au/charcot-marie-tooth-disease

  Both bracing and orthopaedic surgery on your feet can improve your mobility and independence. […] People of all ages with CMT should be assessed for appropriate bracing. Bracing can improve your quality of life. Good bracing can also delay or remove the need for orthopaedic surgery. […] You may need orthopaedic (bone) surgery at some point. This may be: to correct foot difference associated with CMT for complications, such as a knee or hip replacement due to osteoarthritis.

• #42 Medications and Charcot-Marie-Tooth Disease | Charcot–Marie–Tooth Association

  https://www.cmtausa.org/living-with-cmt/managing-cmt/medications/

  There currently are no available treatments that act to slow the progression of Charcot-Marie-Tooth disease. […] However, there are medications that doctors may prescribe to you to help treat the symptoms of CMT rather than the disease itself. […] Medications can play a crucial role in helping you cope with the symptoms and improve your quality of life. […] On this page, you will find information about a variety of medication types that a person with CMT may be prescribed for managing symptoms or comorbid diseases. […] CMT often causes chronic, neuropathic pain that makes day-to-day life with Charcot-Marie-Tooth disease more difficult. If neuropathy is causing pain that diminishes quality of life, then this symptom should be treated. […] The risk is minimal if the drugs are indicated. Some of these agents have been studied as treatments for neuropathic pain and showed no signs of making patients worse.

• #43 Medications and Charcot-Marie-Tooth Disease | Charcot–Marie–Tooth Association

  https://www.cmtausa.org/living-with-cmt/managing-cmt/medications/

  There currently are no available treatments that act to slow the progression of Charcot-Marie-Tooth disease. […] However, there are medications that doctors may prescribe to you to help treat the symptoms of CMT rather than the disease itself. […] Medications can play a crucial role in helping you cope with the symptoms and improve your quality of life. […] On this page, you will find information about a variety of medication types that a person with CMT may be prescribed for managing symptoms or comorbid diseases. […] CMT often causes chronic, neuropathic pain that makes day-to-day life with Charcot-Marie-Tooth disease more difficult. If neuropathy is causing pain that diminishes quality of life, then this symptom should be treated. […] The risk is minimal if the drugs are indicated. Some of these agents have been studied as treatments for neuropathic pain and showed no signs of making patients worse.

• #44 Medications and Charcot-Marie-Tooth Disease | Charcot–Marie–Tooth Association

  https://www.cmtausa.org/living-with-cmt/managing-cmt/medications/

  There currently are no available treatments that act to slow the progression of Charcot-Marie-Tooth disease. […] However, there are medications that doctors may prescribe to you to help treat the symptoms of CMT rather than the disease itself. […] Medications can play a crucial role in helping you cope with the symptoms and improve your quality of life. […] On this page, you will find information about a variety of medication types that a person with CMT may be prescribed for managing symptoms or comorbid diseases. […] CMT often causes chronic, neuropathic pain that makes day-to-day life with Charcot-Marie-Tooth disease more difficult. If neuropathy is causing pain that diminishes quality of life, then this symptom should be treated. […] The risk is minimal if the drugs are indicated. Some of these agents have been studied as treatments for neuropathic pain and showed no signs of making patients worse.

• #45 Medications and Charcot-Marie-Tooth Disease | Charcot–Marie–Tooth Association

  https://www.cmtausa.org/living-with-cmt/managing-cmt/medications/

  There currently are no available treatments that act to slow the progression of Charcot-Marie-Tooth disease. […] However, there are medications that doctors may prescribe to you to help treat the symptoms of CMT rather than the disease itself. […] Medications can play a crucial role in helping you cope with the symptoms and improve your quality of life. […] On this page, you will find information about a variety of medication types that a person with CMT may be prescribed for managing symptoms or comorbid diseases. […] CMT often causes chronic, neuropathic pain that makes day-to-day life with Charcot-Marie-Tooth disease more difficult. If neuropathy is causing pain that diminishes quality of life, then this symptom should be treated. […] The risk is minimal if the drugs are indicated. Some of these agents have been studied as treatments for neuropathic pain and showed no signs of making patients worse.

• #46 Charcot-Marie-Tooth disease | Beacon Health System

  https://www.beaconhealthsystem.org/library/diseases-and-conditions/charcot-marie-tooth-disease?content_id=CON-20155112

  There’s no cure for Charcot-Marie-Tooth disease. But the disease generally progresses slowly, and it doesn’t affect expected life span. […] There are some treatments to help you manage Charcot-Marie-Tooth disease. […] Charcot-Marie-Tooth disease may sometimes cause pain due to muscle cramps or nerve damage. If pain is an issue for you, prescription pain medication may help control your pain. […] Physical therapy can help strengthen and stretch your muscles to prevent muscle tightening and loss. A program usually includes low-impact exercises and stretching techniques guided by a trained physical therapist and approved by your doctor. Started early and followed regularly, physical therapy can help prevent disability. […] Occupational therapy can help through the use of assistive devices, such as special rubber grips on doorknobs, or clothing with snaps instead of buttons.

• #47 Medications and Charcot-Marie-Tooth Disease | Charcot–Marie–Tooth Association

  https://www.cmtausa.org/living-with-cmt/managing-cmt/medications/

  Cymbalta (duloxetine) is one of the few medications that went through the lengthy process to receive FDA approval for neuropathic pain, specifically for diabetic neuropathy, but is generally used for any type of neuropathy-associated pain. […] Venlafaxine (Effexor) is a popular and widely used antidepressant that is also used to treat neuropathic pain, especially well studied in patients with diabetic neuropathy, although the drug has no current specific FDA indication for this use. […] According to our CMT experts, Botox is not recommended for individuals with CMT but can be used in areas that are not directly affected by CMT (the face, for example). […] There is no listed contraindication to the use of alendronate (Fosamax) in patients with CMT. […] Muscle relaxers like Soma should not affect your nerves or strength, but may cause sedation or sleepiness.

• #48 Medications and Charcot-Marie-Tooth Disease | Charcot–Marie–Tooth Association

  https://www.cmtausa.org/living-with-cmt/managing-cmt/medications/

  Cymbalta (duloxetine) is one of the few medications that went through the lengthy process to receive FDA approval for neuropathic pain, specifically for diabetic neuropathy, but is generally used for any type of neuropathy-associated pain. […] Venlafaxine (Effexor) is a popular and widely used antidepressant that is also used to treat neuropathic pain, especially well studied in patients with diabetic neuropathy, although the drug has no current specific FDA indication for this use. […] According to our CMT experts, Botox is not recommended for individuals with CMT but can be used in areas that are not directly affected by CMT (the face, for example). […] There is no listed contraindication to the use of alendronate (Fosamax) in patients with CMT. […] Muscle relaxers like Soma should not affect your nerves or strength, but may cause sedation or sleepiness.

• #49 Charcot-Marie-Tooth (CMT): Symptoms, causes, types, and treatment

  https://www.medicalnewstoday.com/articles/172056

  There is no cure for CMT, but treatment may relieve symptoms and delay the start of physical disabilities. […] Non-steroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen, can help reduce joint and muscle pain and pain caused by damaged nerves. […] Tricyclic antidepressants (TCAs) may be prescribed if NSAIDs are not effective. TCAs are normally used to treat depression, but they may relieve neuropathic pain. However, they may have side effects. […] Physical therapy uses low-impact exercises to help strengthen and stretch the muscles. This can help to maintain muscle strength for longer and prevent muscle tightening. […] Occupational therapy may help patients who have problems with finger movements and gripping, because this can make it very hard to carry out daily activities.

• #50 Medications and Charcot-Marie-Tooth Disease | Charcot–Marie–Tooth Association

  https://www.cmtausa.org/living-with-cmt/managing-cmt/medications/

  Cymbalta (duloxetine) is one of the few medications that went through the lengthy process to receive FDA approval for neuropathic pain, specifically for diabetic neuropathy, but is generally used for any type of neuropathy-associated pain. […] Venlafaxine (Effexor) is a popular and widely used antidepressant that is also used to treat neuropathic pain, especially well studied in patients with diabetic neuropathy, although the drug has no current specific FDA indication for this use. […] According to our CMT experts, Botox is not recommended for individuals with CMT but can be used in areas that are not directly affected by CMT (the face, for example). […] There is no listed contraindication to the use of alendronate (Fosamax) in patients with CMT. […] Muscle relaxers like Soma should not affect your nerves or strength, but may cause sedation or sleepiness.

• #51 Medications and Charcot-Marie-Tooth Disease | Charcot–Marie–Tooth Association

  https://www.cmtausa.org/living-with-cmt/managing-cmt/medications/

  Cymbalta (duloxetine) is one of the few medications that went through the lengthy process to receive FDA approval for neuropathic pain, specifically for diabetic neuropathy, but is generally used for any type of neuropathy-associated pain. […] Venlafaxine (Effexor) is a popular and widely used antidepressant that is also used to treat neuropathic pain, especially well studied in patients with diabetic neuropathy, although the drug has no current specific FDA indication for this use. […] According to our CMT experts, Botox is not recommended for individuals with CMT but can be used in areas that are not directly affected by CMT (the face, for example). […] There is no listed contraindication to the use of alendronate (Fosamax) in patients with CMT. […] Muscle relaxers like Soma should not affect your nerves or strength, but may cause sedation or sleepiness.

• #52 Medications and Charcot-Marie-Tooth Disease | Charcot–Marie–Tooth Association

  https://www.cmtausa.org/living-with-cmt/managing-cmt/medications/

  We know of no evidence linking their use to worsening or causing neuropathy, abnormal muscle cramps or muscle spasm. […] There are no reported contraindications for persons with peripheral neuropathies taking these over-the-counter drugs: tylenol, aspirin, and Advil. […] The statin drugs are safe for most patients with CMT. There is no evidence that one statin is any better or worse as a risk factor for neuropathy.

• #53 Medications and Charcot-Marie-Tooth Disease | Charcot–Marie–Tooth Association

  https://www.cmtausa.org/living-with-cmt/managing-cmt/medications/

  We know of no evidence linking their use to worsening or causing neuropathy, abnormal muscle cramps or muscle spasm. […] There are no reported contraindications for persons with peripheral neuropathies taking these over-the-counter drugs: tylenol, aspirin, and Advil. […] The statin drugs are safe for most patients with CMT. There is no evidence that one statin is any better or worse as a risk factor for neuropathy.

• #54 Charcot-Marie-Tooth disease | Beacon Health System

  https://www.beaconhealthsystem.org/library/diseases-and-conditions/charcot-marie-tooth-disease?content_id=CON-20155112

  Many people with Charcot-Marie-Tooth disease require the help of certain orthopedic devices to maintain everyday mobility and to prevent injury. Leg and ankle braces or splints can provide stability while walking and climbing stairs. […] If foot deformities are severe, corrective foot surgery may help alleviate pain and improve your ability to walk. Surgery can’t improve weakness or loss of sensation. […] Researchers are investigating a number of potential therapies that may one day treat Charcot-Marie-Tooth disease. Potential therapies include medications, gene therapy and in vitro procedures that may help prevent passing the disease to future generations.

• #55 Current Treatment Methods for Charcot–Marie–Tooth Diseases

  https://www.mdpi.com/2218-273X/14/9/1138

  Orthoses is another CMT management method that complements rehabilitative approaches and plays an important role in improving balance, gait, and the ability to perform the activities of daily life. […] As the disease progresses, orthotic foot wear may be required to slow down the development of deformities, supporting against foot drop, stabilizing gait, and reducing pain or sores. […] Over time, the deformities of CMT patients tend to progress in severity. […] In the early stages of the condition, flexible deformities including equines, cavus, or forefoot valgus and hindfoot varus can be corrected by joint-sparing osteotomies, soft-tissue release, and tendon transfers, with elaborate preoperative evaluation and individualized plans. […] As physiotherapy, proper foot care, and surgery are not enough to ameliorate CMT-related symptoms, additional symptomatological drugs are used.

• #56 Charcot-Marie-Tooth Disease Causes, Symptoms, Treatment | HSS

  https://www.hss.edu/condition-list_charcot-marie-tooth-disease.asp

  How is Charcot-Marie-Tooth disease treated? Charcot-Marie-Tooth disease is initially treated with physical therapy, daily stretching, and braces. These primary treatments help with maintenance of balance and stability with ambulation. Currently, clinical trials are being conducted for medical and gene therapies. Surgery is performed to correct deformities and rebalance muscles to optimize mobility and gait efficiency. […] The goal of surgery for Charcot-Marie-Tooth disease is to help preserve or improve movement and function as the condition progresses. The most common locations for procedures in CMT are at the foot and ankle. Other areas that may benefit from surgery include the hip (to prevent dislocation), the knee (to avoid kneecap dislocation), and the spine to correct and stabilize scoliosis.

• #57 Charcot-Marie-Tooth Disease Causes, Symptoms, Treatment | HSS

  https://www.hss.edu/condition-list_charcot-marie-tooth-disease.asp

  Surgery to address foot and ankle weakness and the potentially painful cavus foot (high arch) requires a multi-step foot-and-ankle reconstruction surgery that includes soft tissue releases and tendon transfers to remove contractures and rebalance muscle forces. Osteotomies or joint fusions are often needed to realign bones to improve foot position to reduce pain and enhance gait efficiency (help the patient walk more naturally and with less effort or strain on the foot). For hip dysplasia, the bones of the femur and pelvis may be repositioned to improve way the hip joint fits together, helping to restore its anatomy and function. For scoliosis, bracing is often ineffective to halt progression of spinal deformity, therefore, spinal fusion is usually the primary treatment option.

• #58 Charcot-Marie-Tooth Disease Causes, Symptoms, Treatment | HSS

  https://www.hss.edu/condition-list_charcot-marie-tooth-disease.asp

  Surgery to address foot and ankle weakness and the potentially painful cavus foot (high arch) requires a multi-step foot-and-ankle reconstruction surgery that includes soft tissue releases and tendon transfers to remove contractures and rebalance muscle forces. Osteotomies or joint fusions are often needed to realign bones to improve foot position to reduce pain and enhance gait efficiency (help the patient walk more naturally and with less effort or strain on the foot). For hip dysplasia, the bones of the femur and pelvis may be repositioned to improve way the hip joint fits together, helping to restore its anatomy and function. For scoliosis, bracing is often ineffective to halt progression of spinal deformity, therefore, spinal fusion is usually the primary treatment option.

• #59

  https://www.footcaremd.org/conditions-treatments/ankle/charcot-marie-tooth-disease

  Currently there is no cure for Charcot-Marie-Tooth disease. Treatment is aimed at helping to manage the symptoms and improve function in the feet and legs. Since maintaining good strength and range of motion is very important, physical therapy may be prescribed. An ankle-foot orthosis (AFO) may be prescribed along with appropriate shoes to help with walking. Medications to help with numbness also may be discussed. Patients with Charcot-Marie-Tooth disease should inspect their feet daily to detect breakdown of the skin. […] In rare situations surgery may be discussed to correct significant deformities around the foot and ankle. These surgical interventions are focused on either fusion, tendon transfers, or both to realign the foot and help balance the forces around the foot causing the deformity.

• #60 Charcot-Marie-Tooth disease | Beacon Health System

  https://www.beaconhealthsystem.org/library/diseases-and-conditions/charcot-marie-tooth-disease?content_id=CON-20155112

  Many people with Charcot-Marie-Tooth disease require the help of certain orthopedic devices to maintain everyday mobility and to prevent injury. Leg and ankle braces or splints can provide stability while walking and climbing stairs. […] If foot deformities are severe, corrective foot surgery may help alleviate pain and improve your ability to walk. Surgery can’t improve weakness or loss of sensation. […] Researchers are investigating a number of potential therapies that may one day treat Charcot-Marie-Tooth disease. Potential therapies include medications, gene therapy and in vitro procedures that may help prevent passing the disease to future generations.

• #61 Current Treatment Methods for Charcot–Marie–Tooth Diseases

  https://pmc.ncbi.nlm.nih.gov/articles/PMC11430469/

  Orthoses is another CMT management method that complements rehabilitative approaches and plays an important role in improving balance, gait, and the ability to perform the activities of daily life. […] As physiotherapy, proper foot care, and surgery are not enough to ameliorate CMT-related symptoms, additional symptomatological drugs are used. […] Drug treatment for CMT primarily focuses on symptom relief, whereas gene therapy aims to ameliorate or potentially cure symptoms of CMT with minimal adverse events by transferring genetic material into the cells of the patients. […] Gene therapy is the treatment of a disease through transferring genetic material into cells of the patients. Gene addition and gene replacement are important methods for gene therapies. […] Current gene editing technology is laying the foundation for the formulation of future disease therapies.

• #62 Current Treatment Methods for Charcot–Marie–Tooth Diseases

  https://www.mdpi.com/2218-273X/14/9/1138

  Drug treatment for CMT primarily focuses on symptom relief, whereas gene therapy aims to ameliorate or potentially cure symptoms of CMT with minimal adverse events by transferring genetic material into the cells of the patients. […] Many promising compounds targeting pathophysiological pathways are being tested as CMT treatments. […] Gene therapy is the treatment of a disease through transferring genetic material into cells of the patients. […] Gene addition and gene replacement are important methods for gene therapies. […] Current gene editing technology is laying the foundation for the formulation of future disease therapies. […] The management of CMT involves a comprehensive approach based on an understanding of pathogenesis and disease progression, encompassing pharmacotherapy, gene therapy, patient education, rehabilitation, and orthopedic surgery.

• #63 Current Treatment Methods for Charcot–Marie–Tooth Diseases

  https://pmc.ncbi.nlm.nih.gov/articles/PMC11430469/

  Orthoses is another CMT management method that complements rehabilitative approaches and plays an important role in improving balance, gait, and the ability to perform the activities of daily life. […] As physiotherapy, proper foot care, and surgery are not enough to ameliorate CMT-related symptoms, additional symptomatological drugs are used. […] Drug treatment for CMT primarily focuses on symptom relief, whereas gene therapy aims to ameliorate or potentially cure symptoms of CMT with minimal adverse events by transferring genetic material into the cells of the patients. […] Gene therapy is the treatment of a disease through transferring genetic material into cells of the patients. Gene addition and gene replacement are important methods for gene therapies. […] Current gene editing technology is laying the foundation for the formulation of future disease therapies.

• #64 Current Treatment Methods for Charcot–Marie–Tooth Diseases

  https://www.mdpi.com/2218-273X/14/9/1138

  Drug treatment for CMT primarily focuses on symptom relief, whereas gene therapy aims to ameliorate or potentially cure symptoms of CMT with minimal adverse events by transferring genetic material into the cells of the patients. […] Many promising compounds targeting pathophysiological pathways are being tested as CMT treatments. […] Gene therapy is the treatment of a disease through transferring genetic material into cells of the patients. […] Gene addition and gene replacement are important methods for gene therapies. […] Current gene editing technology is laying the foundation for the formulation of future disease therapies. […] The management of CMT involves a comprehensive approach based on an understanding of pathogenesis and disease progression, encompassing pharmacotherapy, gene therapy, patient education, rehabilitation, and orthopedic surgery.

• #65 Treatment Is in Sight for Charcot-Marie-Tooth Disease

  https://www.medscape.com/viewarticle/last-treatment-sight-charcot-marie-tooth-disease-2024a1000iys

  Theres no medical treatment for Charcot-Marie-Tooth (CMT) disease, a debilitating neurologic disorder thats both progressive and incurable. […] Genetic-based therapies are currently in preclinical research phases, and an experimental small-molecule drug has reached phase 3 in humans, neurologists told an audience here at the American Association of Neuromuscular Electrodiagnostic Medicine (AANEM) 2024. […] In regard to genetic treatment, Bipasha Mukherjee-Clavin, MD, PhD, of Johns Hopkins University School of Medicine, Baltimore, said a key factor is whether the patients form of CMT is passed on in an autosomal dominant or autosomal recessive manner. […] A tool like CRISPR could be used to directly edit the part of the genome with a CMT-causing mutation or a viral vector could deliver a healthy, wild-type copy of a gene, she said.

• #66 Treatment Is in Sight for Charcot-Marie-Tooth Disease

  https://www.medscape.com/viewarticle/last-treatment-sight-charcot-marie-tooth-disease-2024a1000iys

  Currently, about seven different projects are in the works on the RNA therapeutics front in CMT, she said, including six focusing on type 1A. […] Mukherjee-Clavin highlighted two RNA therapeutic products that she expects to move from preclinical to clinical research soon. […] One is TVR110 by Armatus Bio, a microRNA intrathecal injection product, which aims to reduce PMP22 overexpression. […] The other therapy, a small interfering RNA intravenous product delivered to Schwann cells, is being developed by DTx Pharma/Novartis. […] Meanwhile, the University of Miamis Saporta highlighted small-molecule strategies that target a subtype of CMT called sorbitol dehydrogenase (SORD) deficiency thats caused by mutations in the SORD gene. […] He noted that Applied Therapeutics is testing an investigational drug called govorestat (AT-007) in 56 patients in a double-blind, randomized, placebo-controlled phase 3 registrational study.

• #67 Treatment Is in Sight for Charcot-Marie-Tooth Disease

  https://www.medscape.com/viewarticle/last-treatment-sight-charcot-marie-tooth-disease-2024a1000iys

  Currently, about seven different projects are in the works on the RNA therapeutics front in CMT, she said, including six focusing on type 1A. […] Mukherjee-Clavin highlighted two RNA therapeutic products that she expects to move from preclinical to clinical research soon. […] One is TVR110 by Armatus Bio, a microRNA intrathecal injection product, which aims to reduce PMP22 overexpression. […] The other therapy, a small interfering RNA intravenous product delivered to Schwann cells, is being developed by DTx Pharma/Novartis. […] Meanwhile, the University of Miamis Saporta highlighted small-molecule strategies that target a subtype of CMT called sorbitol dehydrogenase (SORD) deficiency thats caused by mutations in the SORD gene. […] He noted that Applied Therapeutics is testing an investigational drug called govorestat (AT-007) in 56 patients in a double-blind, randomized, placebo-controlled phase 3 registrational study.

• #68 Treatment Is in Sight for Charcot-Marie-Tooth Disease

  https://www.medscape.com/viewarticle/last-treatment-sight-charcot-marie-tooth-disease-2024a1000iys

  Currently, about seven different projects are in the works on the RNA therapeutics front in CMT, she said, including six focusing on type 1A. […] Mukherjee-Clavin highlighted two RNA therapeutic products that she expects to move from preclinical to clinical research soon. […] One is TVR110 by Armatus Bio, a microRNA intrathecal injection product, which aims to reduce PMP22 overexpression. […] The other therapy, a small interfering RNA intravenous product delivered to Schwann cells, is being developed by DTx Pharma/Novartis. […] Meanwhile, the University of Miamis Saporta highlighted small-molecule strategies that target a subtype of CMT called sorbitol dehydrogenase (SORD) deficiency thats caused by mutations in the SORD gene. […] He noted that Applied Therapeutics is testing an investigational drug called govorestat (AT-007) in 56 patients in a double-blind, randomized, placebo-controlled phase 3 registrational study.

• #69 Gene Therapy | CMT Research Foundation

  https://cmtrf.org/gene-therapy/

  Charcot-Marie-Tooth is influenced significantly by genetics with over 100 genes directly involved in its development. […] Gene therapy is a technique aiming to modify or control gene expression to treat or cure diseases. For CMT, gene therapy can correct genetic mutations by replacing, adding, silencing, or modifying affected genes. […] Learning from successful gene therapies in other neuromuscular disorders has provided valuable insights for CMT treatment. While gene therapy shows promise, ongoing research and clinical trials are essential for safety and effectiveness. […] The potential CMT1A therapy from Armatus Bio is based on a completed CMTRF-funded research project from Dr. Kleopas Kleopa at the Cyprus Institute of Neurology and Genetics in collaboration with Dr. Scott Q. Harper and his team at Nationwide Children’s Hospital. The team developed a vectorized RNAi-based therapy for CMT1A that is aimed at reducing or eliminating disease symptoms by lowering levels of excess PMP22, the culprit behind CMT1A.

• #70 Treatment Is in Sight for Charcot-Marie-Tooth Disease

  https://www.medscape.com/viewarticle/last-treatment-sight-charcot-marie-tooth-disease-2024a1000iys

  Currently, about seven different projects are in the works on the RNA therapeutics front in CMT, she said, including six focusing on type 1A. […] Mukherjee-Clavin highlighted two RNA therapeutic products that she expects to move from preclinical to clinical research soon. […] One is TVR110 by Armatus Bio, a microRNA intrathecal injection product, which aims to reduce PMP22 overexpression. […] The other therapy, a small interfering RNA intravenous product delivered to Schwann cells, is being developed by DTx Pharma/Novartis. […] Meanwhile, the University of Miamis Saporta highlighted small-molecule strategies that target a subtype of CMT called sorbitol dehydrogenase (SORD) deficiency thats caused by mutations in the SORD gene. […] He noted that Applied Therapeutics is testing an investigational drug called govorestat (AT-007) in 56 patients in a double-blind, randomized, placebo-controlled phase 3 registrational study.

• #71 NMD Pharma’s Charcot-Marie-Tooth disease treatment granted ODD by FDA – Pharmafile

  https://pharmafile.com/news/nmd-pharmas-charcot-marie-tooth-disease-treatment-granted-odd-by-fda/

  Biotech company NMD Pharma has announced that the US Food and Drug Association (FDA) have granted its Charcot-Marie-Tooth (CMT) disease treatment NMD670 orphan drug designation (ODD). […] NMD670 is a small molecule inhibitor of the skeletal muscle-specific chloride ion channel CIC-1. […] In November 2024, NMD Pharma announced the initiation of the phase 2 clinical trial SYNAPSE-CMT, which will test a twice-daily oral dose of NMD670 over 21 days in 80 adult patients with any genetically confirmed CMT1 or CMT2 subtype. […] Based on positive results from preclinical studies and the recently published ESTABLISH1 CMT observational study, this designation not only highlights the urgent need for novel, effective treatments for this rare disease, but also underscores the therapeutic potential of our skeletal muscle-specific ClC-1 inhibitor approach to address the associated muscle weakness and fatigue.

• #72 NMD Pharma’s Charcot-Marie-Tooth disease treatment granted ODD by FDA – Pharmafile

  https://pharmafile.com/news/nmd-pharmas-charcot-marie-tooth-disease-treatment-granted-odd-by-fda/

  Biotech company NMD Pharma has announced that the US Food and Drug Association (FDA) have granted its Charcot-Marie-Tooth (CMT) disease treatment NMD670 orphan drug designation (ODD). […] NMD670 is a small molecule inhibitor of the skeletal muscle-specific chloride ion channel CIC-1. […] In November 2024, NMD Pharma announced the initiation of the phase 2 clinical trial SYNAPSE-CMT, which will test a twice-daily oral dose of NMD670 over 21 days in 80 adult patients with any genetically confirmed CMT1 or CMT2 subtype. […] Based on positive results from preclinical studies and the recently published ESTABLISH1 CMT observational study, this designation not only highlights the urgent need for novel, effective treatments for this rare disease, but also underscores the therapeutic potential of our skeletal muscle-specific ClC-1 inhibitor approach to address the associated muscle weakness and fatigue.

• #73 Experimental Treatments for Charcot–Marie–Tooth Disease | Charcot-Marie-Tooth NewsEnvelope icon

  https://charcot-marie-toothnews.com/experimental-treatments-for-charcot-marie-tooth-disease-2/

  PXT3003 is being developed to reduce the levels of PMP22 gene expression. It is a combination of three already approved treatments: baclofen, naltrexone, and sorbitol. A pivotal Phase 3 trial is currently enrolling. […] Ricolinostat (ACY-1215), designed to restore nerve function by inhibiting the histone deacetylase 6 protein, is being developed to treat CMT type 2, as well as diabetic and chemotherapy-induced peripheral neuropathy. A Phase 2 trial in CMT2 patients is currently enrolling.

• #74 Charcot-Marie-Tooth Disease Medication: Nonsteroidal anti-inflammatory drugs, Cyclooxygenase-2 inhibitors, Tricyclic antidepressants, Anticonvulsants, Analgesics

  https://emedicine.medscape.com/article/1232386-medication

  PLEO-CMT was a 15-month double-blind study that assessed the efficacy and safety of two doses of PXT3003 as compared with placebo in 323 patients (age range, 16-65 years) with mild-to-moderate CMT 1A. […] An animal study published in 2019 found that early short-term PXT3003 combinational therapy delayed disease onset in a transgenic rat model of CMT 1A.

• #75 Experimental Treatments for Charcot–Marie–Tooth Disease | Charcot-Marie-Tooth NewsEnvelope icon

  https://charcot-marie-toothnews.com/experimental-treatments-for-charcot-marie-tooth-disease-2/

  PXT3003 is being developed to reduce the levels of PMP22 gene expression. It is a combination of three already approved treatments: baclofen, naltrexone, and sorbitol. A pivotal Phase 3 trial is currently enrolling. […] Ricolinostat (ACY-1215), designed to restore nerve function by inhibiting the histone deacetylase 6 protein, is being developed to treat CMT type 2, as well as diabetic and chemotherapy-induced peripheral neuropathy. A Phase 2 trial in CMT2 patients is currently enrolling.

• #76 Effective Charcot Marie Tooth Disease Treatment

  https://drchandrilchugh.com/charcot-marie-tooth-disease/effective-charcot-marie-tooth-disease-treatments/

  Researchers are actively exploring potential future treatments for Charcot Marie Tooth Disease, including the use of medications, gene therapy, and stem cell research. […] While there is no cure for Charcot Marie Tooth Disease, individuals can optimize their quality of life and maintain overall well-being by combining medical treatments with self-care practices.

• #77 Charcot–Marie–Tooth disease – Wikipedia

  https://en.wikipedia.org/wiki/Charcot%E2%80%93Marie%E2%80%93Tooth_disease

  Currently, there is no cure for CMT; however, treatments such as physical therapy, orthopedic devices, surgery, and medications can help manage symptoms and improve quality of life. […] Physical and occupational therapy can help preserve muscle strength, flexibility, and mobility. […] Orthopedic devices like ankle-foot orthoses (AFOs) are commonly used to correct foot drop and improve gait. In some cases, surgical interventions may be necessary to straighten toes, lower arches, or fuse joints to enhance stability. Pain management may involve physical therapy, assistive devices, or medications for neuropathic pain. […] Patients are advised to avoid prolonged immobility, which can accelerate disease progression. Regular follow-up with healthcare providers is essential to adapt care as the disease progresses.

• #78 Charcot–Marie–Tooth disease – Wikipedia

  https://en.wikipedia.org/wiki/Charcot%E2%80%93Marie%E2%80%93Tooth_disease

  Currently, there is no cure for CMT; however, treatments such as physical therapy, orthopedic devices, surgery, and medications can help manage symptoms and improve quality of life. […] Physical and occupational therapy can help preserve muscle strength, flexibility, and mobility. […] Orthopedic devices like ankle-foot orthoses (AFOs) are commonly used to correct foot drop and improve gait. In some cases, surgical interventions may be necessary to straighten toes, lower arches, or fuse joints to enhance stability. Pain management may involve physical therapy, assistive devices, or medications for neuropathic pain. […] Patients are advised to avoid prolonged immobility, which can accelerate disease progression. Regular follow-up with healthcare providers is essential to adapt care as the disease progresses.

• #79 Charcot-Marie-Tooth disease (CMT) – Muscular Dystrophy UK

  https://www.musculardystrophyuk.org/conditions/a-z/charcot-marie-tooth-disease-cmt/

  Orthotic devices are often recommended to improve walking and help reduce the risk of falls. These could be insoles in shoes, ankle or leg braces, or custom-made shoes to provide better ankle support. […] Foot care is very important for people with CMT. This is because the loss of feeling in the feet means injuries, ulcers, or sores, may not be felt or noticed right away. […] For those experiencing joint or nerve pain, there are medications to help ease the pain. For people with significant foot deformities that are causing pain, surgery may be helpful. There are procedures that can help to correct foot deformities, making it easier to balance on the feet and walk.

• #80 Charcot-Marie-Tooth Disease – OrthoInfo – AAOS

  https://orthoinfo.aaos.org/en/diseases–conditions/charcot-marie-tooth-disease/

  Medication. Although CMT causes loss of sensation, some patients have pain due to nerve damage or muscle cramping. Your or your child’s doctor can prescribe medication to help relieve these types of pain. […] Your or your child’s doctor may recommend surgery to correct foot deformities. Procedures to straighten toes or lower arches can help improve foot positioning and relieve pain. Surgery can also help address shoe-wear problems. […] Although surgery can address bone deformity, it cannot improve muscle weakness or sensory loss.

• #81 Charcot-Marie-Tooth Disease Medication: Nonsteroidal anti-inflammatory drugs, Cyclooxygenase-2 inhibitors, Tricyclic antidepressants, Anticonvulsants, Analgesics

  https://emedicine.medscape.com/article/1232386-medication

  Avoid drugs and medications known to cause nerve damage (eg, vincristine, isoniazid, and nitrofurantoin). Identify the cause of any pain as accurately as possible. Musculoskeletal pain may respond to acetaminophen or nonsteroidal anti-inflammatory drugs (NSAIDs). Neuropathic pain may respond to tricyclic antidepressants or antiepileptic drugs, such as carbamazepine or gabapentin. […] Dyck et al, as well as Ginsberg et al, have described a few individuals with Charcot-Marie-Tooth (CMT) disease type 1 and sudden deterioration in whom treatment with steroids (prednisone) or intravenous immunoglobulin produced variable levels of improvement. […] An exploratory randomized double-blind and placebo-controlled phase 2 study of a combination of baclofen, naltrexone and sorbitol (PXT3003) in patients with CMT 1A confirmed that PXT3003 was a safe and well-tolerated treatment for adults with this condition.

• #82

  https://www.footcaremd.org/conditions-treatments/ankle/charcot-marie-tooth-disease

  Charcot-Marie-Tooth disease is a progressive disorder and will require continued treatment throughout a patient’s lifetime. As changes occur based on the progression of the disorder it will be important to have regular check-ups with your doctor. Usually treatment will be a team approach with your foot and ankle orthopaedic surgeon working and several other specialists helping with your care. If symptoms change or worsen prior to your regular check-up it is important to contact your doctor and be seen early.

• #83 Treatment – Charcot-Marie-Tooth UK

  https://www.cmt.org.uk/cmt-and-you/managing-cmt/treatment/

  Treatments exist for many of the complications of CMT, at present there are no disease-modifying therapies to either halt the progression or cure CMT. However, many aspects of the condition can be managed for most people. […] Current treatments include physiotherapy, orthotics, occupational therapy, pain and fatigue management and when indicated orthopaedic surgery, speech therapy and respiratory support. […] CMT should be treated by people who know about the condition. This means that treatment should be overseen by a consultant neurologist (or paediatric neurologist) with a specialist interest in peripheral neuropathy (which includes CMT) or a rehabilitation medicine physician with an interest in neuromuscular conditions. […] A neurologist specialises in understanding how nerves work, what can go wrong with them, the likely course of any problems, and what treatments and care options may help.

• #84 Treatment – Charcot-Marie-Tooth UK

  https://www.cmt.org.uk/cmt-and-you/managing-cmt/treatment/

  Treatments exist for many of the complications of CMT, at present there are no disease-modifying therapies to either halt the progression or cure CMT. However, many aspects of the condition can be managed for most people. […] Current treatments include physiotherapy, orthotics, occupational therapy, pain and fatigue management and when indicated orthopaedic surgery, speech therapy and respiratory support. […] CMT should be treated by people who know about the condition. This means that treatment should be overseen by a consultant neurologist (or paediatric neurologist) with a specialist interest in peripheral neuropathy (which includes CMT) or a rehabilitation medicine physician with an interest in neuromuscular conditions. […] A neurologist specialises in understanding how nerves work, what can go wrong with them, the likely course of any problems, and what treatments and care options may help.

• #85 Charcot-Marie-Tooth Disease – OrthoInfo – AAOS

  https://orthoinfo.aaos.org/en/diseases–conditions/charcot-marie-tooth-disease/

  Charcot-Marie-Tooth disease is a group of disorders that affect the peripheral nerves the nerves that carry messages between the brain and muscles throughout the body. […] Although there is no cure for Charcot-Marie-Tooth disease, there are many treatment options and assistive devices to help people manage physical challenges and lead fulfilling lives. […] There is no cure for Charcot-Marie-Tooth disease. However, there are many treatment options to help you or your child manage the effects of the disorder. […] Several medical specialists are typically involved in the ongoing care of people with CMT. These include orthopaedic surgeons, physical therapists, occupational therapists, orthotists, and podiatrists. […] Physical therapy. Specific exercises to improve muscle strength and flexibility will help you or your child maintain mobility and independence. A physical therapist can develop a program that includes: Strengthening exercises, Stretching, Muscle endurance activities such as low-impact aerobics and swimming.

• #86 CMT Clinic | UI Health

  https://uicdss2.ingeniuxondemand.com/primary-and-specialty-care/neurology-and-neurosurgery/neurological-conditions-we-treat/neuromuscular-disease/our-expertise/cmt-clinic

  The CMT Clinic at UI Health, created in partnership with the Charcot Marie Tooth Association (CMTA) directed by Dr. Charles Abrams, brings together a team of medical professionals to meet with and treat patients in one setting, all in one day. The multidisciplinary approach allows our patients to not only have an opportunity to discuss their medical needs with a neuromuscular specialist and with a comprehensive team of medical professionals who are well versed in CMT, including genetic counselors, physical therapists, occupational therapists, orthotists, dietitians, social workers, and nurses. […] The clinic team provides important medical care for patients and keeps them updated on the latest research and treatment landscape while also helping them in the management of their disease in a supportive, specialized, collaborative environment.

• #87 CMT Clinic | UI Health

  https://uicdss2.ingeniuxondemand.com/primary-and-specialty-care/neurology-and-neurosurgery/neurological-conditions-we-treat/neuromuscular-disease/our-expertise/cmt-clinic

  The CMT Clinic at UI Health, created in partnership with the Charcot Marie Tooth Association (CMTA) directed by Dr. Charles Abrams, brings together a team of medical professionals to meet with and treat patients in one setting, all in one day. The multidisciplinary approach allows our patients to not only have an opportunity to discuss their medical needs with a neuromuscular specialist and with a comprehensive team of medical professionals who are well versed in CMT, including genetic counselors, physical therapists, occupational therapists, orthotists, dietitians, social workers, and nurses. […] The clinic team provides important medical care for patients and keeps them updated on the latest research and treatment landscape while also helping them in the management of their disease in a supportive, specialized, collaborative environment.

• #88 Charcot-Marie-Tooth Disease: Symptoms & Treatments | Ada Health

  https://ada.com/conditions/charcot-marie-tooth-disease/

  There is no cure for Charcot-Marie-Tooth, but treatment can help relieve the symptoms […] Charcot-Marie-Tooth disease treatment focuses on relieving your symptoms and supporting you in your daily activities. Your healthcare provider may recommend: […] Physical therapy in order to improve your balance and strength […] Occupational therapy to help you with your daily activities […] Certain medical devices such as walking aids to increase your quality of life […] Psychological support to help you cope with the diagnosis […] There is no cure for Charcot-Marie-Tooth disease, but there are several treatment options that can help you relieve your symptoms and improve your quality of life. Your healthcare provider may recommend physical therapy, occupational therapy, or walking aids.

• #89 Charcot-Marie-Tooth (CMT): Symptoms, causes, types, and treatment

  https://www.medicalnewstoday.com/articles/172056

  Assistive devices, such as orthopedic devices, braces or splints, can help the individual stay mobile and prevent injury. Shoes with high tops or special boots provide extra ankle support, and special shoes or shoe inserts can improve gait. Thumb splints may help with dexterity. […] Cognitive behavioral therapy (CBT) can help patients with CMT to cope better with everyday life and, if necessary, with depression. […] Surgery to fuse bones in the feet or to remove part of a tendon can sometimes alleviate pain and make walking easier. Surgery can correct flat feet, relieve joint pain and correct heel deformities. […] Patients who also have scoliosis, or curvature of the spine, may need a back brace and sometimes surgery.

• #90 Charcot-Marie-Tooth Disease – Seattle Children’s

  https://www.seattlechildrens.org/conditions/charcot-marie-tooth-disease/

  Occupational therapy to help your child with activities like writing, dressing and using a computer keyboard. […] Shoe inserts or braces for your childs ankles and feet to help them walk more easily. […] Braces to support their fingers and thumbs to help with writing and other tasks. […] Orthopedic surgery for conditions like hammertoe, high arches, scoliosis or kyphosis. […] Medicines to ease any pain your child may have. […] If needed, devices that help your child walk or get around, such as a cane, walker, wheelchair or motorized scooter. […] A dietitian will work with you and your child to make sure they get the nutrition that supports their best growth and development. […] A social worker helps your child and family with coping, social relationships, behavior and emotions. Along with your childs doctors, nurses and therapists, the social worker will connect you with helpful resources at Seattle Childrens and in the community.

• #91 Charcot-Marie-Tooth Disease Treatment | UVA Health

  https://uvahealth.com/services/neurology/charcot-marie-tooth-disease

  No matter which type you have, Charcot-Marie-Tooth disease can be difficult to live with. […] While theres no cure for Charcot-Marie-Tooth disease, we can help reduce your symptoms and increase your quality of life. […] Physical therapy is an important part of CMT treatment. […] Our prosthetics and orthotics team offers assistive devices like braces, orthotics, and shoe inserts to support your feet and ankles. […] If you have pain, we may be able to treat it with medication. […] In severe cases, we may do surgery to correct foot or hand deformities, stop nerve compression, or release tight tendons to make moving easier. […] We offer occupational therapy to help with everyday tasks. […] We also have social workers who can help with the stress of having an ongoing illness.

• #92 Charcot Marie Tooth | Memorial Hermann

  https://memorialhermann.org/services/conditions/charcot-marie-tooth

  The CMT Association is a fantastic resource for families living with CMT. Through the CMT Association, you can access educational newsletters, webinars and conferences, and stay apprised of important research updates. There are also opportunities to personally connect with other CMT families locally, regionally and nationally. Visit cmtausa.org to learn more.

• #93 Charcot-Marie-Tooth Disease (CMT) | Rady Children’s Hospital

  https://www.rchsd.org/health-article/charcot-marie-tooth-disease-cmt/

  How Is Charcot-Marie-Tooth Disease (CMT) Treated? […] There is no cure for CMT disease yet. The treatment goal is to help the child stay as active as possible. Because of the loss of feeling, avoiding injury from impact and burns requires extra care. […] Treatments to help children stay as active as possible include: […] Braces, such as ankle-foot orthoses (AFOs), to support the feet for easier walking. […] Medicines for pain relief. […] Physical therapy (PT) exercises and stretching to help maintain strength and flexibility. […] Occupational therapy (OT) to help with managing tasks at home, school, and work. […] Surgery to loosen tight tendons and joints (contractures). […] […] […] Often, CMT symptoms are not severe, and many treatments can help. People with CMT have a normal life expectancy, and most can walk their entire lives. Support groups can help you and your child they can connect you to other families who are managing CMT and keep you up to date on treatment research.

• #94 Understanding CMT: Symptoms & Management

  https://www.cmtausa.org/understanding-cmt/what-is-cmt/

  There currently is no treatment or cure for this debilitating and often overlooked disease. […] TREATING CMT IS A HIGHLY INDIVIDUALIZED APPROACH TO SYMPTOM MANAGEMENT. There arent yet any approved treatments for CMT. However, the many symptoms and presentations of CMT can be well-managed. Each person who has CMT has their own individual needs. Physical and occupational therapy, proper foot and ankle orthoses (AFOs), remaining as active as one can, surgical intervention to correct foot deformities, and surgical intervention to correct hand deformities are just some of the ways CMT symptoms are managed. […] CMTA is aggressively pursuing treatments and a cure for all types of CMT. Since launching the Strategy to Accelerate Research (STAR) in 2008, CMTA has been working with preeminent researchers, clinicians, patients and institutions in the global inherited neuropathy community to capitalize on breakthroughs in genetics.

• #95 Understanding CMT: Symptoms & Management

  https://www.cmtausa.org/understanding-cmt/what-is-cmt/

  CMTA has made unprecedented progress toward therapies for virtually almost all types of CMT. Since the inception of STAR, CMTA has financed more than 100 projects and committed over $23.5 million in research. Thanks to support from our donors, STAR continues to gain momentum and the promise of breakthroughs is imminent.

• #96 Charcot-Marie-Tooth Disease – New Gene Therapy Shows Potential in Early Trial for Charcot-Marie-Tooth Disease

  https://www.hnf-cure.org/triad/triad-clinical-trial-rediness/new-gene-therapy-shows-potential-in-early-trial-for-charcot-marie-tooth-disease/

  A recent clinical trial has shown promising results for a new treatment option for people living with Charcot-Marie-Tooth (CMT) disease. The therapy involves a special type of gene medicine that uses a plasmid (a small, circular piece of DNA) to deliver a gene that may help nerve and muscle function. […] Researchers developed a plasmid that allows for the production of two forms of a protein called hepatocyte growth factor (HGF), which has been shown to support nerve growth and improve blood flow in studies. […] The treatment was well tolerated by most participants. […] Importantly, there were no serious side effects, and none of the patients developed antibodies against the HGF protein, meaning their bodies didn’t reject the treatment. […] By the end of the study, participants showed some improvements:

• #97 Charcot-Marie-Tooth Disease – New Gene Therapy Shows Potential in Early Trial for Charcot-Marie-Tooth Disease

  https://www.hnf-cure.org/triad/triad-clinical-trial-rediness/new-gene-therapy-shows-potential-in-early-trial-for-charcot-marie-tooth-disease/

  A recent clinical trial has shown promising results for a new treatment option for people living with Charcot-Marie-Tooth (CMT) disease. The therapy involves a special type of gene medicine that uses a plasmid (a small, circular piece of DNA) to deliver a gene that may help nerve and muscle function. […] Researchers developed a plasmid that allows for the production of two forms of a protein called hepatocyte growth factor (HGF), which has been shown to support nerve growth and improve blood flow in studies. […] The treatment was well tolerated by most participants. […] Importantly, there were no serious side effects, and none of the patients developed antibodies against the HGF protein, meaning their bodies didn’t reject the treatment. […] By the end of the study, participants showed some improvements:

• #98 Charcot-Marie-Tooth Disease – New Gene Therapy Shows Potential in Early Trial for Charcot-Marie-Tooth Disease

  https://www.hnf-cure.org/triad/triad-clinical-trial-rediness/new-gene-therapy-shows-potential-in-early-trial-for-charcot-marie-tooth-disease/

  Based on these encouraging results, a larger Phase 2 study is being considered to confirm these findings and explore whether the treatment could benefit more people with CMT type 1A. […] This early research shows hope for a potential new therapy that could improve daily functioning and quality of life for people living with CMT.

• #99 Charcot-Marie-Tooth Disease – New Gene Therapy Shows Potential in Early Trial for Charcot-Marie-Tooth Disease

  https://www.hnf-cure.org/triad/triad-clinical-trial-rediness/new-gene-therapy-shows-potential-in-early-trial-for-charcot-marie-tooth-disease/

  Based on these encouraging results, a larger Phase 2 study is being considered to confirm these findings and explore whether the treatment could benefit more people with CMT type 1A. […] This early research shows hope for a potential new therapy that could improve daily functioning and quality of life for people living with CMT.

• #100 A new approach to treat Charcot-Marie-Tooth (CMT) Disease • healthcare-in-europe.com

  https://healthcare-in-europe.com/en/news/new-treat-charcot-marie-tooth-cmt.html

  The research team led by Professor Minseok Kim from the Department of New Biology at DGIST has developed a technology that can treat Charcot-Marie-Tooth disease, an incurable hereditary disease, with electric stimulation instead of drug therapy. […] The core of this technology is electric stimulation that restores the abnormal distribution of peripheral myelin protein 22 (PMP 22), the cause of the disease, to normal. […] This electric stimulation eliminated the PMP22 protein aggregation around the nucleus that occurs in CMT1A disease and restored the normal distribution of the PMP22 protein towards the cell membrane, similar to that of a normal Schwann cell. […] The key of this study is that it is the first demonstration that electric stimulation can restore the normal distribution of PMP22, which is a major protein in CMT1A disease. […] We hope that new electric medicine technologies will soon be commercialized to address CMT disease that currently has no cure and causes suffering to millions of people worldwide.

• #101 A new approach to treat Charcot-Marie-Tooth (CMT) Disease • healthcare-in-europe.com

  https://healthcare-in-europe.com/en/news/new-treat-charcot-marie-tooth-cmt.html

  The research team led by Professor Minseok Kim from the Department of New Biology at DGIST has developed a technology that can treat Charcot-Marie-Tooth disease, an incurable hereditary disease, with electric stimulation instead of drug therapy. […] The core of this technology is electric stimulation that restores the abnormal distribution of peripheral myelin protein 22 (PMP 22), the cause of the disease, to normal. […] This electric stimulation eliminated the PMP22 protein aggregation around the nucleus that occurs in CMT1A disease and restored the normal distribution of the PMP22 protein towards the cell membrane, similar to that of a normal Schwann cell. […] The key of this study is that it is the first demonstration that electric stimulation can restore the normal distribution of PMP22, which is a major protein in CMT1A disease. […] We hope that new electric medicine technologies will soon be commercialized to address CMT disease that currently has no cure and causes suffering to millions of people worldwide.

Zobacz więcej