Materiały źródłowe

• #1 Human Papillomavirus (HPV) Vaccine Safety | Vaccine Safety | CDC

  https://www.cdc.gov/vaccine-safety/vaccines/hpv.html

  Some HPV infections can be persistent and can progress to cancer in both women and men later in life. […] HPV vaccine is safe and effective at preventing HPV-related infections and cancers. […] Many people who get the HPV vaccine have no side effects at all. The most common side effects are usually mild, like a sore arm from the shot. […] The most common side effect reported was pain, swelling, and redness in the arm where the shot was given. […] These mild side effects may occur more often after Gardasil 9 vaccination than after Gardasil. […] Reports of swelling and redness also increased with each following dose for those receiving Gardasil 9. […] About 92% of the Gardasil reports were classified as non-serious. The most common adverse events reported were: syncope (fainting); dizziness; nausea; headache; fever; and injection site reactions (pain, swelling, and redness).

• #2 HPV vaccine: Who needs it, how it works

  https://www.mayoclinic.org/diseases-conditions/hpv-infection/in-depth/hpv-vaccine/art-20047292

  Most of the time, the body can find and clear out HPV. But if the virus stays in the body for a long time, it can cause cancer. Getting vaccinated against HPV helps prevent cancer in men and women. […] The HPV vaccine has been found to be safe in many studies. Overall, the effects tend to be mild. The most common side effects of HPV vaccines include soreness, swelling or redness at the injection site. Sometimes dizziness or fainting occurs after the shot. Staying seated for 15 minutes after the shot can lower the risk of fainting. Headaches, nausea, vomiting, fatigue or weakness also may occur. […] Get medical attention right away if you notice any symptoms of cervical cancer. Some symptoms are vaginal bleeding after sex, between periods or after menopause; pelvic pain; or pain during sex.

• #3 HPV Vaccine Side Effects – Superdrug Health Clinic

  https://healthclinics.superdrug.com/hpv-vaccine-side-effects/

  The HPV vaccine may cause some minor and temporary side effects in some patients immediately after the injection. Common immediate side effects of the HPV vaccination include: Redness, swelling, or bruising at the site of the injection […] Mild muscle and joint pain. Rare side effects of the HPV vaccination include: Itchy red rash […] Breathing difficulties. These side effects apply to all vaccines – be aware that most of these symptoms are typical of any kind of vaccination, and are not a result of the HPV vaccination specifically. The HPV vaccine has no side effects that are uniquely associated with it. […] The evidence shows no long-term side effects – there is no evidence to suggest that the HPV vaccination has any long term side effects, or is responsible for any long term health complications. This includes illnesses that are sometimes associated with the HPV vaccine, such as chronic fatigue syndrome. These claims have not been clinically proven to be accurate.

• #4 Safety and Side Effects of GARDASIL®9 (Human Papillomavirus 9-valent Vaccine, Recombinant)

  https://www.gardasil9.com/patient-pd/what-is-gardasil-9/safety-and-side-effects/

  The most common side effects of GARDASIL 9 include: pain, swelling, redness, itching, bruising, bleeding, and a lump where your child got the shot […] Fainting can happen after getting an HPV vaccine. Sometimes people who faint can fall and hurt themselves. For this reason, your childs doctor may ask them to sit or lie down for 15 minutes after they get GARDASIL 9. Some people who faint might shake or become stiff, which may need treatment. […] The side effects include pain, swelling, redness, itching, bruising, bleeding, and a lump where you got the shot; headache; fever; nausea; and dizziness.

• #5 HPV Vaccines – NCCC

  https://www.nccc-online.org/hpv-vaccines/

  The HPV vaccine is designed to prevent infection. It can’t treat HPV-related disease. […] Over 135 million doses of the HPV vaccine have been distributed in the U.S. since the vaccine was licensed and over 270 million have been distributed worldwide. In both clinical trials before the vaccine was approved by the FDA and in use, the vaccine has proven to be safe and well tolerated. […] As with any vaccine or medication, there is always the possibility of side effects. There have been some mild to moderate reactions reported from people who have received the vaccines. The most common side effects associated with the HPV vaccine are: Pain, redness, and swelling around the injection site. In clinical trials, local reactions such as pain, redness, or swelling were reported by anywhere from 20% to 90% of recipients.

• #6 Human Papillomavirus Vaccine Side Effects: Common, Severe, Long Term

  https://www.drugs.com/sfx/human-papillomavirus-vaccine-side-effects.html

  Along with its needed effects, human papillomavirus vaccine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. […] Check with your doctor or nurse immediately if any of the following side effects occur while taking human papillomavirus vaccine: […] Some side effects of human papillomavirus vaccine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. […] The most common adverse events were injection site reactions, fatigue, headache, and myalgia. […] Very common (10% or more): Injection site pain (91.9%), injection site swelling (49%), injection site erythema (48.4%). […] Very common (10% or more): Fatigue (54.6%), headache (53.4%), pyrexia (13%), fever of 99.5F or higher (12.9%).

• #7 HPV vaccine – NHS

  https://www.nhs.uk/vaccinations/hpv-vaccine/

  The most common side effects of the HPV vaccine are mild and do not last long. […] They can include: swelling or pain where the injection was given, a headache, a high temperature, dizziness, feeling sick, tiredness. […] More serious side effects such as a severe allergic reaction are very rare. The person who vaccinates you will be trained to deal with allergic reactions and treat them immediately.

• #8 Human papillomavirus vaccine (intramuscular route) – Mayo Clinic

  https://www.mayoclinic.org/drugs-supplements/human-papillomavirus-vaccine-intramuscular-route/description/drg-20127679

  Human papillomavirus (HPV) vaccine helps prevent anal, cervical, vulvar, vaginal, oropharyngeal (mouth and throat), or head and neck cancer, genital warts, and abnormal or precancerous diseases of the anus, cervix, vagina, and vulva in girls and women 9 to 45 years of age. […] This vaccine may cause a serious type of allergic reaction called anaphylaxis, which can be life-threatening and requires immediate medical attention. Tell your doctor right away if you or your child has a rash, itching, swelling of the tongue and throat, or trouble with breathing after you get the injection. […] You or your child may feel faint, lightheaded, or dizzy right after you receive this vaccine. Sitting or lying down for 15 minutes after you receive the vaccine may help. If any of these side effects occur, do not drive or do anything else that could be dangerous until you know how this medicine affects you.

• #9 Human Papillomavirus Vaccine Side Effects: Common, Severe, Long Term

  https://www.drugs.com/sfx/human-papillomavirus-vaccine-side-effects.html

  Very common (10% or more): Myalgia (48.8%), arthralgia (20.7%). […] Common (1% to 10%): Nausea, diarrhea, vomiting, abdominal pain upper, toothache. […] Common (1% to 10%): Dizziness, migraine. […] Common (1% to 10%): Insomnia. […] Common (1% to 10%): Dysmenorrhea, vaginal infection, urinary tract infection. […] Common (1% to 10%): Rash, urticaria, itching/pruritus. […] Human papillomavirus vaccine side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

• #10 Human Papillomavirus (HPV): Symptoms, Diagnosis and Prevention

  https://www.unitypoint.org/find-a-service/primary-care/vaccinations/human-papillomavirus-hpv-vaccine

  Its rare, but HPV can also cause warts to grow in the respiratory tract. You may experience a hoarse voice, trouble breathing or have a chronic cough. […] Yes. The HPV vaccine has undergone rigorous safety testing and is extremely effective. To date, more than 100 studies in millions of people all over the world show the HPV vaccine is safe. […] As with any vaccine, the most common side effects include: Soreness at the injection site, Mild fever, Fatigue, Headache.

• #11 Safety and Side Effects of GARDASIL®9 (Human Papillomavirus 9-valent Vaccine, Recombinant)

  https://www.gardasil9.com/patient-pd/what-is-gardasil-9/safety-and-side-effects/

  The most common side effects of GARDASIL 9 include: pain, swelling, redness, itching, bruising, bleeding, and a lump where your child got the shot […] Fainting can happen after getting an HPV vaccine. Sometimes people who faint can fall and hurt themselves. For this reason, your childs doctor may ask them to sit or lie down for 15 minutes after they get GARDASIL 9. Some people who faint might shake or become stiff, which may need treatment. […] The side effects include pain, swelling, redness, itching, bruising, bleeding, and a lump where you got the shot; headache; fever; nausea; and dizziness.

• #12 Safety Profile and Possible Side Effects of GARDASIL®9 (Human Papillomavirus 9-valent Vaccine, Recombinant)

  https://www.gardasil9.com/patient-a/what-is-gardasil-9/safety-and-side-effects/

  Pain, swelling, redness, itching, bruising, bleeding, and a lump where you got the shot; headache; fever; nausea; and dizziness. […] Fainting can happen after getting GARDASIL 9. Sometimes people who faint can fall and hurt themselves. For this reason, the health care professional may ask the person getting GARDASIL 9 to sit or lie down for 15 minutes after getting the vaccine. Some people who faint might shake or become stiff. […] The side effects include pain, swelling, redness, itching, bruising, bleeding, and a lump where you got the shot; headache; fever; nausea; and dizziness.

• #13 HPV Vaccine Side Effects – Superdrug Health Clinic

  https://healthclinics.superdrug.com/hpv-vaccine-side-effects/

  Most side effects of the HPV vaccine occur immediately and are unlikely to cause any long-term health complications – if you believe that you are experiencing any side effects after receiving the HPV vaccine, inform the nurse or pharmacist who administered the vaccination as soon as possible. […] The most common side effect is a sore arm – the area around the site of the injection may turn red and feel sore after your vaccination, which can last for up to 2 days. You may also develop a mild fever – some people develop a fever shortly after being vaccinated, as your body starts to produce antibodies to protect you from infection. […] Your safety is the most important thing – if you are concerned that you are experiencing side effects, no matter how minor they may seem, you should speak to a doctor or call NHS 111. If you believe you are experiencing severe side effects, such as breathing difficulties or an allergic reaction, call 999 immediately to receive emergency treatment.

• #14 HPV vaccine safety and side effects

  https://www.hpvvaccine.org.au/hpv-vaccine/hpv-vaccine-safety-and-side-effects

  The HPV vaccination has been offered continuously under Australia’s National Immunisation Program since 2007. […] Side effects after receiving the HPV vaccine are usually only very mild. The reactions that people have had after the HPV vaccine are similar to reactions from other vaccines which include pain, redness and swelling at the site of the injection. […] These symptoms occur in about four in five cases and should go away quickly. They can be treated with an ice pack or paracetamol if needed. […] People are monitored for 15 minutes after having the HPV vaccine. If an allergic reaction or, more rarely, a more serious allergic reaction called anaphylaxis, does occur, it can be treated quickly and successfully. […] For every million doses of the vaccine given, there are only about three cases of anaphylaxis. This is a similar rate for other vaccines given to children.

• #15 Articles | HPV Vaccine Side Effects: What’s Normal & When to Seek Help

  https://www.secondspringwomen.com/articles/hpv-vaccine-side-effects-whats-normal-and-when-to-seek-help

  After receiving the HPV vaccine, most people will experience mild side effects, similar to those caused by other vaccines. These side effects are typically short-lived and go away on their own within a few days. […] It’s important to remember that these side effects are normal and indicate that the body is responding to the vaccine. […] One of the most common side effects of the HPV vaccine is pain or tenderness at the site of the injection. This is a typical reaction for many vaccines and usually lasts only a few hours to a day. Some people may also experience redness or swelling around the injection site.

• #16 Human papillomavirus (HPV) and immunisation | Better Health Channel

  https://www.betterhealth.vic.gov.au/health/healthyliving/human-papillomavirus-hpv-immunisation

  Discomfort at the injection site usually only lasts a couple of days and gets better on its own. […] The HPV vaccine protects against 9 strains of HPV that cause: over 90% of cervical cancers, over 95 % of HPV-related cancers. […] The vaccine prevents the disease caused by HPV, but does not treat existing HPV infections. If you have symptoms of active HPV infection, you should see a medical professional. […] The HPV vaccine has undergone rigorous testing to ensure it is safe, and side effects experienced after HPV vaccination are usually mild and get better on their own within a few days. […] The chance of a severe reaction from Gardasil9 is very small, and the risks from not being vaccinated against diseases caused by HPV may be very serious. […] Yes the vaccine doesn’t prevent all types of HPV infection that cause cervical cancer.

• #17 Human Papillomavirus (HPV) Vaccine Safety | Vaccine Safety | CDC

  https://www.cdc.gov/vaccine-safety/vaccines/hpv.html

  The risk of getting GBS following HPV vaccination is extremely rare. […] Ongoing safety monitoring has not detected any safety concerns related to POTS following HPV vaccination. […] Evidence does not support a causal link between HPV vaccines and CRPS. […] Studies show no increased risk of ME/CFS among girls given HPV vaccine. […] Evidence does not suggest a causal link between Gardasil and death.

• #18 Side effects and safety of the Gardasil vaccine

  https://blog.walgreens.com/health/vaccines-immunizations/gardasil-vaccine.html

  HPV (human papillomavirus) is the most common sexually transmitted infection (STI) in the United States. […] The most common side effects seen with the Gardasil9 vaccine are usually mild. These can include fever, headache or pain, redness, or swelling where the shot was given. […] Additionally, some people faint after getting the HPV vaccine, although this is rare. […] On very rare occasions, severe allergic reactions (anaphylactic) may occur after receiving any vaccination or medication. Symptoms of a severe allergic reaction can include hives, swelling of the face, tongue, and throat, difficulty breathing, a fast heartbeat, dizziness and weakness. […] The vaccine safety surveillance system overseen by the CDC and the FDA received several reports of death following Gardasil9 vaccination from December 1, 2014 through December 31, 2017. […] After careful review of every reported death, the CDC concluded that these extremely rare occurrences were not causally linked to the HPV vaccine. […] All relevant studies have shown no deaths directly linked to any HPV vaccine, including Gardasil9.

• #19 HPV (human papillomavirus) vaccine – what you need to know: MedlinePlus Medical EncyclopediaLock

  https://medlineplus.gov/ency/article/007648.htm

  HPV vaccine may be given to adults 27 through 45 years of age, based on discussions between the patient and health care provider. […] Risks of a vaccine reaction include soreness, redness, or swelling where the shot is given can happen after HPV vaccination. […] Fever or headache can happen after HPV vaccination. […] People sometimes faint after medical procedures, including vaccination. […] As with any medicine, there is a very remote chance of a vaccine causing a severe allergic reaction, other serious injury, or death. […] An allergic reaction could occur after the vaccinated person leaves the clinic. If you see signs of a severe allergic reaction (hives, swelling of the face and throat, difficulty breathing, a fast heartbeat, dizziness, or weakness), call 9-1-1 or your local emergency number and get the person to the nearest hospital.

• #20 Does the Gardasil vaccine do more harm than good? | Cancer Council

  https://www.cancer.org.au/iheard/does-the-gardasil-vaccine-do-more-harm-than-good

  Current evidence indicates the two vaccines developed to protect against human papillomavirus (HPV), Gardasil and Cervarix, are effective and safe to use. […] Although no vaccine is completely without side effects, the great majority of events have been mild and common, for example temporary soreness, swelling and redness at the site of the injection. Many of the reported events (such as headache, or feeling dizzy or unwell) may be equally common in people of the same age who have not received the vaccine. […] There have been some reports of neurological symptoms similar to those present with multiple sclerosis, however these reports have been investigated by an independent panel of medical experts in Australia, which found no proof of a link to Gardasil. The number of these events is no more than would be expected by chance. […] Based on doses distributed in Australia, the current estimated risk of severe allergic reaction, anaphylaxis, is 2.6 in a million risk, which is why practitioners giving the vaccine have the necessary medical equipment and drugs on site.

• #21

  https://www.who.int/groups/global-advisory-committee-on-vaccine-safety/topics/human-papillomavirus-vaccines/safety

  Since licensure in 2006, over 270 million doses of HPV vaccines have been distributed. GACVS first reviewed the safety data in 2007, and subsequently in 2008, 2009, 2013, 2014, and 2015. Early on, the Committee was presented signals related to anaphylaxis and syncope. The risk of anaphylaxis has been characterized as approximately 1.7 cases per million doses, and syncope was established as a common anxiety or stress-related reaction to the injection. No other adverse reactions have been identified and GACVS considers HPV vaccines to be extremely safe. […] In addition, GACVS was presented with new studies assessing other safety concerns, again from the US, as well as from Denmark. These studies included examination of specific outcomes that included complex regional pain syndrome (CRPS), postural orthostatic tachycardia syndrome (POTS), premature ovarian insufficiency, primary ovarian failure, and a further look at the risk of venous thromboembolism. With now large population level data from several countries, the Committee saw no new evidence for a causal association between HPV vaccine and those conditions.

• #22 Questions and Answers about HPV and the Vaccine | Children’s Hospital of Philadelphia

  https://www.chop.edu/vaccine-education-center/vaccine-details/human-papillomavirus/prevent-hpv

  HPV infections can last up to 24 months before the immune system eliminates the infection. During this time, most people do not know they are infected. This is why it is difficult to stop transmission of the virus. […] HPV virus can cause persistent infections. This means that when a person is infected, the virus is reproducing in the cells that line the infected area. It does not live silently inside of cells like herpes viruses. This means that when the immune system clears the infection, it is no longer present, so it cannot be spread to someone else. […] HPV infects epithelial cells that line mucosal surfaces of the body. When HPV enters these cells, such as in the throat, genital tract or anus, it causes the cells to produce HPV proteins. In most cases, the immune system recognizes the cells that are infected and eliminates them, clearing the infection. However, in some instances a persistent infection occurs causing the cells to mutate, or change. These mutations can ultimately lead to cancer.

• #23 HPV (Human Papillomavirus): Causes, Symptoms & Treatment

  https://my.clevelandclinic.org/health/diseases/11901-hpv-human-papilloma-virus

  HPV that affects your genitals doesnt usually cause symptoms. When symptoms do occur, the most common sign of the virus is warts in your genital area. Genital warts are rough, cauliflower-like lumps that grow on your skin. They may also appear like skin tags. They may appear weeks, months or even years after youve been infected with low-risk HPV. Genital warts are contagious (like all forms of HPV). They can also be itchy and very uncomfortable. […] High-risk forms of HPV often dont cause symptoms until theyve progressed to cancer. […] The virus itself doesnt turn into cancer. But high-risk strains of HPV infection can cause precancerous cell changes. These cell changes can eventually lead to cancer if they arent managed. This process, though, can take years or decades to happen. Screenings, like Pap smears, can help detect these precancerous cells before they turn to cancer. […] Only a small number of people with high-risk HPV will develop abnormal cervical cells that require treatment to prevent the cells from becoming cancer.

• #24 Ask The Experts About Vaccines: HPV (Human Papillomavirus) | Immunize.org

  https://www.immunize.org/ask-experts/topic/hpv/

  Most HPV infections are asymptomatic and go away completely on their own within 2 years after infection (usually in the first 6 months) without causing clinical disease. Some infections are persistent and can lead to genital warts, precancerous lesions, or cancer. […] It can take years, even decades, for HPV infections to lead to cancer. […] Each year, between 2016 and 2020, nearly 12,000 cases of cervical cancer, the most widely known HPV-associated cancer, occurred in the United States. HPV is also associated with vulvar, and vaginal cancer in females, penile cancer in males, and anal and oropharyngeal cancer in both females and males. […] There is no treatment for infection with the HPV virus itself. Only HPV-associated lesions including genital warts, recurrent respiratory papillomatosis, precancers, and cancers are treated.

• #25 LAC | DPH – Vaccine Preventable Disease Control Program

  http://ph.lacounty.gov/ip/diseases/HPV/index.htm

  Most people infected with HPV will not have symptoms until the infection has already caused health problems. […] HPV infections go away by themselves, but types of HPV infections persist longer and cause complications including warts and cancer. […] HPV infections can also cause genital warts. Genital warts are harmless growths on the skin that may appear on the vagina, vulva, cervix, penis, scrotum, or anus. […] HPV vaccination is the most effective way to prevent severe infection and HPV-related cancers. […] HPV vaccination prevents more than 90% of HPV related cancers. […] HPV vaccine is not recommended for use during pregnancy. Vaccination should be delayed until after the pregnancy.

• #26 Immunizations: Human Papillomavirus (HPV) Vaccine and HPV-Related Cancers | Wisconsin Department of Health Services

  https://www.dhs.wisconsin.gov/immunization/hpv.htm

  HPV is a common virus that can lead to certain types of cancer later in life. Most people with HPV have no symptoms, so they usually don’t even know they’re infected. […] Some types of HPV infections cause warts. Other types can cause cancers of the: Cervix, vagina, and vulva in women. Penis in men. Anus in both women and men. Back of the throat (called oropharyngeal cancer), including the base of the tongue and tonsils, in both men and women. […] It usually takes years after being infected with HPV for cancer to develop. […] There is no treatment for the virus itself. However, there may be treatments for the health problems caused by HPV. […] Most HPV infections go away by themselves within two years. […] The HPV vaccine is very safe. Millions of people have safely gotten their HPV vaccine. Over 15 years of monitoring have shown that HPV vaccines are very safe and effective. […] As with any vaccine, there may be minor side effects that include: Low fever. Headache. Pain and redness in the arm where the vaccine was given. […] HPV vaccination gives long-lasting protection against cancer-causing infections and precancers.

• #27 What to know about HPV vaccination | UNICEF Kosovo Programme

  https://www.unicef.org/kosovoprogramme/stories/what-know-about-hpv-vaccination

  The HPV vaccine protects against cancers and genital warts caused by the human papillomavirus, more commonly known as HPV. […] Most people with HPV do not have any symptoms and do not know they have the infection. Some people only find out that they have HPV when they get genital warts. Women may find out they have HPV when they get an abnormal Pap-test result. […] The HPV vaccine is very safe. Millions of children around the world have received the vaccine. […] Like any other vaccine or medicine, it can have side effects. Most of those who have the vaccine don’t experience side effects or the side effects are mild. […] The most common side effects may include redness, swelling or pain at the injection site, which should go away in a couple of days. Others include a mild fever, bruising or itching at the site of the injection, nausea and pain in the arms, hands, fingers, legs or toes. Serious side effects, such as difficulty breathing, are extremely rare. […] As for all vaccines, the benefits of the HPV vaccine far outweigh any of the potential risks.

• #28 Questions and Answers about HPV and the Vaccine | Children’s Hospital of Philadelphia

  https://www.chop.edu/vaccine-education-center/vaccine-details/human-papillomavirus/prevent-hpv

  Progression from an initial HPV infection to cancer requires prolonged infection with one of the types of HPV that causes cancer. For this reason, cervical cancer typically develops 20 to 25 years after the initial HPV infection. Regular Pap tests and HPV tests will help your doctor monitor for precancerous changes to the cells of the cervix.

• #29 Human Papillomavirus (HPV) Vaccines – NCI

  https://www.cancer.gov/about-cancer/causes-prevention/risk/infectious-agents/hpv-vaccine-fact-sheet

  HPV vaccines protect against infection with human papillomaviruses (HPV). HPV is a group of more than 200 related viruses, of which more than 40 are spread through direct sexual contact. Among these, two HPV types cause genital warts, and about a dozen HPV types can cause certain types of cancercervical, anal, oropharyngeal, penile, vulvar, and vaginal. […] Clinical trials have shown that HPV vaccines are highly effective in preventing cervical infection with the types of HPV they target when given before first exposure to the virusthat is, before individuals begin to engage in sexual activity. HPV vaccines have also been found to reduce infections in other tissues that HPV infects, including the anus and oral region. […] Because the cell changes and cancers caused by HPV take years to develop, it has only recently been confirmed that the vaccines reduce the risk of these outcomes as well. Trials and real-world data from population-based studies have now demonstrated that the vaccines greatly reduce the risk of precancers and cancers of the cervix, vagina, and vulva in vaccinated women.

• #30 HPV (Human Papillomavirus): Causes, Symptoms & Treatment

  https://my.clevelandclinic.org/health/diseases/11901-hpv-human-papilloma-virus

  HPV that affects your genitals doesnt usually cause symptoms. When symptoms do occur, the most common sign of the virus is warts in your genital area. Genital warts are rough, cauliflower-like lumps that grow on your skin. They may also appear like skin tags. They may appear weeks, months or even years after youve been infected with low-risk HPV. Genital warts are contagious (like all forms of HPV). They can also be itchy and very uncomfortable. […] High-risk forms of HPV often dont cause symptoms until theyve progressed to cancer. […] The virus itself doesnt turn into cancer. But high-risk strains of HPV infection can cause precancerous cell changes. These cell changes can eventually lead to cancer if they arent managed. This process, though, can take years or decades to happen. Screenings, like Pap smears, can help detect these precancerous cells before they turn to cancer. […] Only a small number of people with high-risk HPV will develop abnormal cervical cells that require treatment to prevent the cells from becoming cancer.

• #31 Preventing HPV infection: HPV Vaccination

  https://www.healthhub.sg/a-z/diseases-and-conditions/faqs-on-hpv-and-hpv-immunisation

  Most HPV infections do not have any signs or symptoms. Some HPV infections may cause genital warts, but they can also cause oral HPV infections such as warts in the mouth or throat or oropharyngeal cancers. […] High-risk HPV infection of the cervix does not cause any signs or symptoms. The abnormality on the cervix is detectable by cervical screening (Pap test) and by HPV DNA (genetic material) tests. […] Symptoms of cervical cancer include abnormal vaginal bleeding such as bleeding after menstrual periods or after sex. There may also be changes in the amount, colour or smell of the vaginal discharge. […] Pain, redness and swelling at the site of injection and headache and fever are some common side effects. They are expected to go away on their own or anti-fever medicines or painkillers may help with the pain, headache and fever. The symptoms of a drug allergy include one or more of the following: […] If you experience any of these symptoms, you should inform your healthcare professional immediately.

• #32 HPV Vaccine and Counseling – Women’s Health Center of Southern Oregon – OB/GYN

  https://womenshealthso.com/hpv-vaccine-and-counseling/

  Most people will get HPV at some point in their lives without even knowing it. Many HPV infections clear up on their own without causing any symptoms. […] HPV is responsible for a range of conditions including: […] High-risk HPV types, particularly HPV 16 and 18, are the main cause of cervical cancer. This cancer often has no early symptoms. So, regular screenings, like Pap tests, are vital. As it progresses, cervical cancer can cause abnormal bleeding, unusual discharge, and pelvic pain. […] HPV can also lead to other types of cancer in both men and women, including: […] Symptoms may include rectal bleeding, pain, and lumps around the anus. […] Symptoms might include a persistent sore throat, trouble swallowing, or a lump in the neck. […] Symptoms include persistent itching, changes in skin color or texture, and abnormal bleeding. […] The HPV vaccine may cause mild side effects. Common side effects include: […] Soreness, redness, or swelling at the injection site […] Headache […] Mild fever […] Fatigue or muscle aches. […] Serious side effects are rare, but if you have concerns, discuss them with your doctor.

• #33 Everything you need to know about the HPV vaccineverifiedverifiedverifiedverifiedverifiedverifiedverifiedverifiedverifiedverified

  https://www.gavi.org/vaccineswork/everything-you-need-know-about-hpv-vaccine

  The HPV vaccine is the most effective way of preventing cervical cancer. The vaccine works best if given before people are exposed to the virus. Therefore, the World Health Organization recommends that to prevent cervical cancer, the HPV vaccine should be given to girls between the age of nine and 14, when most are not yet sexually active. […] Side effects of the HPV vaccine are mild and common to many vaccines, including: soreness, redness or swelling in the arm where the jab was given, fever, dizziness, nausea, headache, tiredness, muscle or joint pain. […] Symptoms include unusual vaginal bleeding or discharge, pain during sex or in the lower back, stomach or hips. However, not everyone has symptoms, and thus cervical cancer screening is incredibly important, as this can detect pre-cancerous cells. Pre-cancerous cells can be treated easily with an outpatient procedure, thereby preventing the development of cancer.

• #34 Human papillomavirus and HPV vaccine – vaccine, immunisation and prevention | healthdirect

  https://www.healthdirect.gov.au/human-papillomavirus-hpv-vaccine

  Human papillomavirus (HPV) is a very common virus that is spread through skin-to-skin contact. There are many different types of HPV that can affect different parts of your body. In most people, HPV doesn’t cause any symptoms, and the virus may goes away by itself, but in some people, HPV causes genital warts or cancer. […] Most people infected with HPV will not have any symptoms. Some types can cause warts on any part of your body, including your genital area. The warts will usually be painless and may be: […] If you are infected with a 'high risk’ type of HPV, the virus can cause changes to your cervical cells that may eventually lead to cervical cancer. There are usually no symptoms, but some people may notice: […] If you notice any of these symptoms, see your doctor. […] The vaccine is very safe. Common side effects last no more than a couple of days. They can include pain, redness and swelling where the needle went in, headache, tiredness, body aches and fever.

• #35 HPV Vaccination Recommendations | CDC

  https://www.cdc.gov/vaccines/vpd/hpv/hcp/recommendations.html

  HPV vaccine is recommended for routine vaccination at age 11 or 12 years. (Vaccination can be started at age 9.) […] HPV vaccination prevents new HPV infections but does not treat existing HPV infections or diseases. HPV vaccine works best when given before any exposure to HPV. […] HPV vaccines are very safe. Scientific research shows the benefits of HPV vaccination far outweigh the potential risks. Like all medical interventions, vaccines can have some side effects. […] The most common adverse reactions reported during clinical trials of HPV vaccines were local reactions at the site of injection. […] A temperature of 100F during the 15 days after vaccination was reported in 10% to 13% of HPV vaccine recipients. […] A variety of systemic adverse reactions have been reported by vaccine recipients, including nausea, dizziness, myalgia, and malaise. However, these symptoms occurred with equal frequency among both HPV vaccine and placebo recipients. […] No serious adverse events have been associated with any HPV vaccine. Ongoing monitoring is conducted by CDC and the Food and Drug Administration.

• #36 Open Search

  https://www.plannedparenthood.org/learn/stds-hiv-safer-sex/hpv/should-i-get-hpv-vaccine

  HPV is one of the most common STDs out there, so its a big relief to know that vaccines will protect you against some types of HPV that can cause problems. […] The HPV vaccine helps protect you against certain types of HPV that can lead to cancer or genital warts. […] The most common side effect is temporary pain and redness where you get the shot. […] Research shows that the vaccine is safe. […] If you already have an HPV infection, getting an HPV vaccine cant treat it. It can, however, protect you from getting other types of HPV. […] The HPV vaccine doesnt change your menstrual cycle or cause infertility. However, if youre pregnant, its best to wait until after your pregnancy to get the HPV vaccine.

• #37 Human Papillomavirus (HPV) Vaccines – NCI

  https://www.cancer.gov/about-cancer/causes-prevention/risk/infectious-agents/hpv-vaccine-fact-sheet

  The vaccines do not prevent other sexually transmitted diseases, nor do they treat existing HPV infections or HPV-caused disease. […] Although HPV vaccines have been found to be safe when given to people who are already infected with HPV, the vaccines provide maximum benefit if a person receives them before he or she is sexually active. […] Yes. Because HPV vaccines do not protect against all HPV types that can cause cancer, women who have been vaccinated are advised to follow the same screening recommendations as unvaccinated women. There could be future changes in screening recommendations for vaccinated women.

• #38 HPV Vaccines | Preventing Human Papillomavirus Infection | American Cancer Society

  https://www.cancer.org/cancer/risk-prevention/hpv/hpv-vaccines.html

  HPV vaccination is cancer prevention. This is why it is important that all children get vaccinated against HPV. […] HPV vaccines can help protect children and young adults from some HPV infections. These vaccines are used to prevent some types of cancer that can result from an HPV infection. They will not treat an HPV infection. And they will not protect against cancer if a person already has an HPV infection. […] The HPV vaccine works very well. Studies have shown that the vaccine provides nearly total protection against infections and pre-cancers caused by the types of HPV that cause 90% of HPV cancers as well as 90% of genital warts. […] Like any vaccination, there may be common mild side effects from the HPV vaccine that usually go away quickly, like headache or fever. There can be pain, redness, and/or swelling where the shot was given. A small number of people may have a more serious side effect that could occur with any vaccine, such as an allergic reaction or fainting when the vaccine is given.

• #39 HPV Vaccines – NCCC

  https://www.nccc-online.org/hpv-vaccines/

  Fever. In clinical trials, 10% to 13% of recipients reported fever, but a similar proportion of trial participants who received a placebo also reported an elevated temperature. […] Headache, fatigue, and nausea. As with fever, these symptoms were reported in equal measure among both HPV vaccine and placebo recipients. […] Some people have experienced fainting as well. For this reason, patients are typically observed for about 15 minutes after each dose of the vaccine. […] The most frequently reported symptoms overall were largely the ones listed above – dizziness, fainting, headache, nausea, fever, and pain, redness, and swelling at the injection site. […] There have been reports of a rare condition called Guillain-Barr Syndrome (GBS) among people who’ve received the vaccine. Experts have not found a connection between GBS and the HPV vaccine.

• #40 HPV vaccine | NHS inform

  https://www.nhsinform.scot/healthy-living/immunisation/vaccines/hpv-vaccine/

  The HPV vaccine does not protect against all types of HPV that can cause cancer. You’ll still need to go for regular cervical screening (smear tests) when you reach 25 years of age. […] Like all medicines, vaccines can cause side effects. This is normal but not everyone gets them. […] The most common side effects of the HPV vaccine usually happen where you had the injection. These can include: soreness, swelling, redness, bruising, itching. […] Other common side effects include: fever, sickness, dizziness, headache. […] If you do experience any of these side effects, they’ll wear off after a couple of days. […] Very rarely, some people have a severe reaction (anaphylactic reaction) soon after vaccination. This causes breathing difficulties and may cause them to collapse. These reactions are extremely rare. The person giving you your vaccine is fully trained to deal with them.

• #41 HPV Vaccines | Preventing Human Papillomavirus Infection | American Cancer Society

  https://www.cancer.org/cancer/risk-prevention/hpv/hpv-vaccines.html

  The HPV vaccine is a safe way to help protect health and the ability to have healthy babies later in life. Research reviews do not suggest that getting the HPV vaccine leads to having fertility problems later in life. In fact, the HPV vaccine can help protect women from future fertility problems that are linked to treatment for cervical cancer and pre-cancer. […] People who have a cervix, even if they have gotten the HPV vaccine, still need regular screening for cervical cancer. This is because the vaccine does not prevent all of the types of HPV that can cause cervical cancer.

• #42 HPV Vaccine Side Effects – Superdrug Health Clinic

  https://healthclinics.superdrug.com/hpv-vaccine-side-effects/

  The HPV vaccine may cause some minor and temporary side effects in some patients immediately after the injection. Common immediate side effects of the HPV vaccination include: Redness, swelling, or bruising at the site of the injection […] Mild muscle and joint pain. Rare side effects of the HPV vaccination include: Itchy red rash […] Breathing difficulties. These side effects apply to all vaccines – be aware that most of these symptoms are typical of any kind of vaccination, and are not a result of the HPV vaccination specifically. The HPV vaccine has no side effects that are uniquely associated with it. […] The evidence shows no long-term side effects – there is no evidence to suggest that the HPV vaccination has any long term side effects, or is responsible for any long term health complications. This includes illnesses that are sometimes associated with the HPV vaccine, such as chronic fatigue syndrome. These claims have not been clinically proven to be accurate.

• #43

  https://www.who.int/groups/global-advisory-committee-on-vaccine-safety/topics/human-papillomavirus-vaccines/safety

  CRPS and POTS continue to be presented as case reports in association with HPV vaccination, particularly from Denmark and Japan. These were initially assessed by GACVS in 2015. These conditions include a spectrum of diverse symptoms, making assessment using administrative health collections challenging. […] Despite the difficulties in diagnosing or fully characterizing CRPS and POTS, reviews of pre- and post-licensure data provide no evidence that these syndromes are associated with HPV vaccination. Some symptoms of CRPS and POTS also overlap with symptoms of chronic fatigue syndrome for which a published observational study reported no association with HPV vaccines. […] Although some cases of POTS reports were severe and long-lasting, the prognosis of POTS with symptomatic management is usually favourable, and symptoms in adolescents often resolve over time. Given the lack of specificity of some of the symptoms reported following HPV vaccination, clinicians are encouraged to refer severely affected patients to physicians familiar with these syndromes for diagnosis and management.

• #44 A cluster analysis of serious adverse event reports after human papillomavirus (HPV) vaccination in Danish girls and young women, September 2009 to August 2017

  https://pmc.ncbi.nlm.nih.gov/articles/PMC6518966/

  Suspected adverse events (AE) after human papillomavirus (HPV) vaccines include postural orthostatic tachycardia syndrome (POTS), chronic fatigue syndrome (CFS), complex regional pain syndrome (CRPS) and symptoms including headache and orthostatic intolerance. […] The most common symptoms were fatigue, dizziness and headache but their frequency varied among clusters. […] Non-specific symptoms including headache, fatigue and dizziness feature prominently in serious AE reports from females in Denmark. Our analysis identified a cluster of reports, likely media stimulated, with a focus on symptoms of CFS and POTS. […] In our study, fatigue, headache and dizziness were the most common AE terms identified in all four clusters of AE reports, particularly in clusters 1-3; this combination was found in 417 (43%) serious AE reports in our study.

• #45 Gardasil HPV Vaccine Lawsuit – The Lanier Law Firm

  https://www.lanierlawfirm.com/gardasil-vaccine-lawsuit/

  As of June 2024, workup of 16 bellwether cases is underway, with trials expected to focus on injuries such as Postural Orthostatic Tachycardia Syndrome (POTS) and Premature Ovarian Insufficiency (POI). […] Since 2022, Merck has faced nearly 200 HPV vaccine claims in the Gardasil Products Liability MDL. Plaintiffs allege they have suffered from serious autoimmune and neurological issues after receiving the vaccine. […] Currently, over 140 complaints concerning Gardasil-related POTS injuries and other autoimmune side effects are pending within the federal court system. […] Scientific research has found that Gardasil induces and increases the risk of many long-term side effects related to autoimmune disorders and reproductive disorders, including: Postural orthostatic tachycardia syndrome (POTs), Premature and/or primary ovarian failure and insufficiency.

• #46 HPV Vaccination Syndrome: A Clinical Mirage, or a New Tragic Fibromyalgia Model | Reumatología Clínica

  https://www.reumatologiaclinica.org/en-hpv-vaccination-syndrome-a-clinical-articulo-S2173574318300741

  Independent investigators have described the onset of a chronic painful dysautonomic syndrome soon after human papillomavirus (HPV) vaccination. The veracity of this syndrome is hotly debated. Many of the reported post-HPV vaccination cases fulfil fibromyalgia diagnostic criteria. […] This article discusses the arguments favoring the existence of a syndrome associated to HPV vaccination. We propose that fibromyalgia dysautonomic-neuropathic model could help in the diagnostic and therapeutic process in those patients in whom the onset of a painful chronic illness began after HPV immunization. On the other hand, if its veracity is corroborated, HPV vaccination syndrome may become a new tragic fibromyalgia model. […] The most frequent presenting symptoms were headache, musculoskeletal pain, fatigue, dizziness/vertigo and paresthesias/allodynia. Overall, 53% of those surveyed met the diagnostic criteria of fibromyalgia. The high COMPASS-31 and S-LANSS scores indicated the presence of severe dysautonomia and severe neuropathic pain.

• #47 A cluster analysis of serious adverse event reports after human papillomavirus (HPV) vaccination in Danish girls and young women, September 2009 to August 2017

  https://pmc.ncbi.nlm.nih.gov/articles/PMC6518966/

  Headache, dizziness and fatigue were prominent features of all four clusters identified from AE reports following HPV vaccination of girls and young women. These are mainly non-specific symptoms and are common occurrences in the target population, so the causation of these symptoms by the HPV vaccine cannot be confirmed by this analysis.

• #48 Hospital Records of Pain, Fatigue, or Circulatory Symptoms in Girls Exposed to Human Papillomavirus Vaccination: Cohort, Self-Controlled Case Series, and Population Time Trend Studies

  https://pmc.ncbi.nlm.nih.gov/articles/PMC7274189/

  Human papillomavirus (HPV) vaccination has been associated with subsequent diffuse symptoms in girls, reducing public confidence in the vaccine. […] The main outcome measures were hospital records of pain, fatigue, or circulatory symptoms. […] The cohort study revealed no increased risk among HPV vaccine-exposed girls, with incidence rate ratios close to 1.0 for abdominal pain, nonspecific pain, headache, hypotension/syncope, tachycardia (including postural orthostatic tachycardia syndrome), and malaise/fatigue (including chronic fatigue syndrome). […] In the SCCS analyses, we observed no association between HPV vaccination and subsequent symptoms. […] The hospital contact rate for abdominal pain was 7.8 per 1,000 person-years during the first year following HPV vaccination versus 8.3 per 1,000 person-years among unvaccinated girls.

• #49

  https://www.who.int/groups/global-advisory-committee-on-vaccine-safety/topics/human-papillomavirus-vaccines/safety

  CRPS and POTS continue to be presented as case reports in association with HPV vaccination, particularly from Denmark and Japan. These were initially assessed by GACVS in 2015. These conditions include a spectrum of diverse symptoms, making assessment using administrative health collections challenging. […] Despite the difficulties in diagnosing or fully characterizing CRPS and POTS, reviews of pre- and post-licensure data provide no evidence that these syndromes are associated with HPV vaccination. Some symptoms of CRPS and POTS also overlap with symptoms of chronic fatigue syndrome for which a published observational study reported no association with HPV vaccines. […] Although some cases of POTS reports were severe and long-lasting, the prognosis of POTS with symptomatic management is usually favourable, and symptoms in adolescents often resolve over time. Given the lack of specificity of some of the symptoms reported following HPV vaccination, clinicians are encouraged to refer severely affected patients to physicians familiar with these syndromes for diagnosis and management.

• #50 Hospital Records of Pain, Fatigue, or Circulatory Symptoms in Girls Exposed to Human Papillomavirus Vaccination: Cohort, Self-Controlled Case Series, and Population Time Trend Studies

  https://pmc.ncbi.nlm.nih.gov/articles/PMC7274189/

  Adjusted IRRs for vaccine-exposed versus unexposed girls were close to 1 for other symptoms: 1.09 (95% CI: 0.96, 1.22) for headache, 0.95 (95% CI: 0.79, 1.14) for nonspecific pain, 0.96 (95% CI: 0.88, 1.06) for hypotension/syncope, 1.14 (95% CI: 0.87, 1.50) for tachycardia (including an IRR of 0.54 (95% CI: 0.19, 1.53) for the POTS subdiagnosis), and 0.90 (95% CI: 0.68, 1.17) for malaise/fatigue (including an IRR of 0.12 (95% CI: 0.02, 0.99) for the CFS subdiagnosis). […] We found no increased rates of hospital records related to pain, fatigue, or circulatory symptoms in girls exposed to HPV vaccine versus unexposed girls. […] These findings do not cause concern about a causal link between HPV vaccination and diffuse autonomic symptoms leading to hospital contacts.

• #51

  https://www.who.int/groups/global-advisory-committee-on-vaccine-safety/topics/human-papillomavirus-vaccines/safety

  GACVS reviewed evidence related to autoimmune disease and the HPV, with a focus on multiple sclerosis (MS). The last review was conducted in June 2013, when the Committee reviewed updated data from the USA, Australia, Japan, and the manufacturers of Cervarix (GlaxoSmithKline) and Gardasil (Merck). With 175 million doses distributed worldwide and more countries offering the vaccine through national immunization programmes, the Committee continued to be reassured by the safety profile of the available products. Serious adverse events that have been reported as potential signals have been investigated in more detail and were not confirmed, including Guillain-Barr syndrome, seizures, stroke, venous thromboembolism, anaphylaxis and other allergic reactions. […] In summary, GACVS was presented with a series of cases of adverse events following administration of the HPV vaccine. Multiple studies have demonstrated no increase in risk of autoimmune diseases, including MS, among girls who have received HPV vaccine compared to those who have not. The Committee remains reassured by the safety profile of the vaccine, but noted the importance of continued surveillance and epidemiological investigation with an emphasis on the collection of high quality data; such data are essential for interpretation of any adverse events which may occur following vaccination.

• #52 HPV Vaccine Side Effects – Superdrug Health Clinic

  https://healthclinics.superdrug.com/hpv-vaccine-side-effects/

  Can the HPV vaccine cause infertility? – there is no evidence to suggest that the HPV vaccine can cause infertility in men or women. In addition, the HPV vaccine has been proven to not increase the risk of serious adverse events during pregnancy, such as miscarriage or pregnancy termination. […] Can the HPV vaccine cause cancer? – the HPV vaccination has not been linked to increasing the chances of developing cancer. In fact, the HPV vaccination protects against high-risk types of HPV that are known to cause cancer. […] Can the HPV vaccine cause autism? – the link between vaccines and autism was first proposed in a 1998 study by Dr Andrew Wakefield, whose work has since been discredited and proven to be false. There is no substantial evidence that any vaccines, including the HPV vaccine, can cause autism.

• #53 Parent Concerns About HPV Vaccine Safety Increasing – NCI

  https://www.cancer.gov/news-events/cancer-currents-blog/2021/hpv-vaccine-parents-safety-concerns

  Despite more than 15 years of consistent evidence that HPV vaccines are safe and effective, a new study has found that more parents are citing concerns about the vaccines safety in recent years. […] During the same time frame, reports of serious health issues after HPV vaccination were consistently rare, the study found. […] HPV vaccines can cause pain, swelling, and redness where the shot was given, as well as headaches, tiredness, and nausea. The most common serious side effects of HPV vaccination are dizziness and fainting. There is no evidence that HPV vaccines lead to infertility or autoimmune diseases, although these are common myths. […] In 2015, 13% of parents had cited safety concerns as the main reason for declining the HPV vaccine. But by 2018, that percentage had risen to 23%. […] Reports of serious health issues after HPV vaccination were consistently rarearound 1.8 per 100,000 HPV vaccine doses, or 0.0018%. A total of 758 serious health problems that arose after HPV vaccination were reported in VAERS during that time.

• #54 Legal Advice on HPV Vaccine Side Effects – Long Term – Jeffrey S. Pop & Associates

  https://www.vaccineinjuryteam.com/hpv-vaccine-side-effects-long-term/

  While some people have expressed reservations about the safety of the HPV vaccine, most information found online on vaccine ineffectiveness is untrue. No evidence suggests that the HPV vaccine has long-term side effects or is responsible for long-term health complications. […] Evidence shows that the HPV vaccine does not cause fertility problems. […] The side effects of the GARDASIL 9 vaccine include pain, swelling, redness, bruising, and bleeding at the point of injection. Other reactions include headache, fever, nausea, and dizziness. […] It is also possible to faint after getting the GARDASIL 9 vaccine. […] Although many HPV vaccine side effects are mild and last for a short while, there is a chance of developing long-term complications. Unfortunately, a vaccine-related injury will likely attract unplanned expenses.

• #55 Long-term Effects of HPV Vaccine in Females – OpalBioPharma

  https://opalbiopharma.com/long-term-effects-of-hpv-vaccine-in-females/

  The symptoms of a severe allergic reaction may include hives, swelling of the face and throat, trouble breathing, a rapid heart rate, dizziness, and weakness. […] There has been a great deal of research in this field, and the purpose of these studies was to determine whether or not the receipt of the HPV vaccination is associated with infertility. […] Reviewers concluded that there is no evidence that HPV vaccination is associated with infertility or primary ovarian insufficiency. […] Despite this, these authorities do not rule out the possibility of side effects; however, these side effects are not sufficient to prevent its use.

• #56 HPV Vaccination Syndrome: A Clinical Mirage, or a New Tragic Fibromyalgia Model | Reumatología Clínica

  https://www.reumatologiaclinica.org/en-hpv-vaccination-syndrome-a-clinical-articulo-S2173574318300741

  Independent investigators have described the onset of a chronic painful dysautonomic syndrome soon after human papillomavirus (HPV) vaccination. The veracity of this syndrome is hotly debated. Many of the reported post-HPV vaccination cases fulfil fibromyalgia diagnostic criteria. […] This article discusses the arguments favoring the existence of a syndrome associated to HPV vaccination. We propose that fibromyalgia dysautonomic-neuropathic model could help in the diagnostic and therapeutic process in those patients in whom the onset of a painful chronic illness began after HPV immunization. On the other hand, if its veracity is corroborated, HPV vaccination syndrome may become a new tragic fibromyalgia model. […] The most frequent presenting symptoms were headache, musculoskeletal pain, fatigue, dizziness/vertigo and paresthesias/allodynia. Overall, 53% of those surveyed met the diagnostic criteria of fibromyalgia. The high COMPASS-31 and S-LANSS scores indicated the presence of severe dysautonomia and severe neuropathic pain.

• #57 HPV Vaccination Syndrome: A Clinical Mirage, or a New Tragic Fibromyalgia Model | Reumatología Clínica

  https://reumatologiaclinica.org/en-hpv-vaccination-syndrome-a-clinical-articulo-S2173574318300741

  Independent investigators have described the onset of a chronic painful dysautonomic syndrome soon after human papillomavirus (HPV) vaccination. The veracity of this syndrome is hotly debated. Many of the reported post-HPV vaccination cases fulfil fibromyalgia diagnostic criteria. […] This article discusses the arguments favoring the existence of a syndrome associated to HPV vaccination. We propose that fibromyalgia dysautonomic-neuropathic model could help in the diagnostic and therapeutic process in those patients in whom the onset of a painful chronic illness began after HPV immunization. On the other hand, if its veracity is corroborated, HPV vaccination syndrome may become a new tragic fibromyalgia model. […] The most frequent presenting symptoms were headache, musculoskeletal pain, fatigue, dizziness/vertigo and paresthesias/allodynia. Overall, 53% of those surveyed met the diagnostic criteria of fibromyalgia. The high COMPASS-31 and S-LANSS scores indicated the presence of severe dysautonomia and severe neuropathic pain.

• #58 HPV Vaccination Syndrome: A Clinical Mirage, or a New Tragic Fibromyalgia Model | Reumatología Clínica

  https://reumatologiaclinica.org/en-hpv-vaccination-syndrome-a-clinical-articulo-S2173574318300741

  In cases of HPV vaccination syndrome, the date of onset of the condition and that of administration of the trigger are well identified. The most widespread symptoms are typical of fibromyalgia: headache, generalized pain, paresthesias and fatigue. […] Individuals who develop a chronic condition after vaccination against HPV have antibodies against key elements of the autonomic nervous system, such as antibodies against adrenergic and muscarinic receptors. […] Independent investigators have reported the development of a fibromyalgia-like chronic syndrome after HPV vaccination. It is difficult to categorize the condition within a specific diagnosis. Recent advances in our understanding of fibromyalgia could provide diagnostic and therapeutic guidelines for the hypothetical HPV vaccination syndrome. On the other hand, should the veracity of HPV vaccination syndrome be corroborated, it could become a new tragic and undesired model of fibromyalgia.

• #59 Symptoms following the criticised HPV vaccine may be due to infections

  https://health.au.dk/en/display/artikel/symptoms-following-the-criticised-hpv-vaccine-may-be-due-to-infections

  Symptoms following the criticised HPV vaccine may be due to infections. A research result from Aarhus University now shows that girls and women who had an infection around the time of the HPV vaccination, had an increased risk of being referred to an HPV centre with possible side effects. In 2015, the Danish television station TV2 sent a documentary called 'The vaccinated girls’, in which a number of girls and women described symptoms such as fatigue, dizziness, headaches, difficulty concentrating, nausea and pain, that they experienced after receiving the HPV vaccine. A new research result from Aarhus University now shows that several of the girls and women who were referred to a HPV centre due to possible side effects, had an infection such as e.g. a sore throat or sinusitis shortly before or shortly after their vaccination. „In some of the cases, the infection may have been a triggering or contributory cause of the symptoms that led to a number of referrals to the HPV centres,” explains Lene Wulff Krogsgaard, who is behind the study which formed part of her PhD dissertation at Aarhus University. „We find the strongest association between possible side effects and infections that have required treatment,” says Lene Wulff Krogsgaard, and emphasises that the possible side effects among girls and women vary widely and do not lead directly to a diagnosis: „There are side effects such as headaches, unexplained fatigue, abdominal pain, nausea, general malaise, fainting, etc. Many of the symptoms are similar to those that also characterise chronic fatigue syndrome. And as the infections have previously been linked to chronic fatigue syndrome, it gave us the idea of investigating the correlation between infections and possible side effects following the vaccine,” explains the researcher. Of these 1,755, a total of 250 had contacted a medical doctor due to an infection, either in the month prior to or the month after the first vaccination, and of these, approximately 200 had an infection that required treatment. „Our results are one piece in the jigsaw puzzle that will help us find an explanation as to why some girls and women experienced possible side effects after receiving the vaccine. Of course this is of interest for these patients, as many of them are looking for answers,” says Lene Wulff Krogsgaard, who emphasises that follow ups are needed before final conclusions can be drawn. […] „We need to confirm these findings, also to clarify whether infections alone or in combination with the HPV vaccine could have caused the symptoms that have been reported,” she says.

• #60 EMA’s mishandling of an investigation into suspected serious neurological harms of HPV vaccines | BMJ Evidence-Based Medicine

  https://ebm.bmj.com/content/27/1/7

  Concern has been raised about whether HPV vaccines might cause serious neurological disorders including postural orthostatic tachycardia syndrome (POTS) and chronic regional pain syndrome (CRPS). […] Even though active comparators were used, our research group found significantly more serious neurological harms in the HPV vaccine groups than in the comparator groups in a systematic review based on clinical study reports in EMAs possession. […] The relationship between HPV vaccines and POTS remains uncertain. […] The changes in the immune system elicited by strongly immunogenic vaccines or adjuvants might render the vaccinated women more susceptible to the development of POTS or CRPS after an otherwise harmless viral illness. […] The briefing note revealed that the Belgian and Swedish corapporteurs were critical of the observed versus expected analyses. […] The experts disagreed on the interpretation of the data.

• #61 HPV Vaccine Side Effects – Superdrug Health Clinic

  https://healthclinics.superdrug.com/hpv-vaccine-side-effects/

  Most side effects of the HPV vaccine occur immediately and are unlikely to cause any long-term health complications – if you believe that you are experiencing any side effects after receiving the HPV vaccine, inform the nurse or pharmacist who administered the vaccination as soon as possible. […] The most common side effect is a sore arm – the area around the site of the injection may turn red and feel sore after your vaccination, which can last for up to 2 days. You may also develop a mild fever – some people develop a fever shortly after being vaccinated, as your body starts to produce antibodies to protect you from infection. […] Your safety is the most important thing – if you are concerned that you are experiencing side effects, no matter how minor they may seem, you should speak to a doctor or call NHS 111. If you believe you are experiencing severe side effects, such as breathing difficulties or an allergic reaction, call 999 immediately to receive emergency treatment.

• #62 HPV Vaccine: Care Instructions | Kaiser Permanente

  https://healthy.kaiserpermanente.org/health-wellness/health-encyclopedia/he.hpv-vaccine-care-instructions.abn0347

  Common side effects of getting the vaccine include headache, fever, and redness or swelling at the site of the shot. […] Call your doctor now or seek immediate medical care if: […] You have a fever for more than 1 day. […] Watch closely for changes in your health, and be sure to contact your doctor if you have any problems.

• #63 HPV vaccine safety and side effects

  https://www.hpvvaccine.org.au/hpv-vaccine/hpv-vaccine-safety-and-side-effects

  The HPV vaccination has been offered continuously under Australia’s National Immunisation Program since 2007. […] Side effects after receiving the HPV vaccine are usually only very mild. The reactions that people have had after the HPV vaccine are similar to reactions from other vaccines which include pain, redness and swelling at the site of the injection. […] These symptoms occur in about four in five cases and should go away quickly. They can be treated with an ice pack or paracetamol if needed. […] People are monitored for 15 minutes after having the HPV vaccine. If an allergic reaction or, more rarely, a more serious allergic reaction called anaphylaxis, does occur, it can be treated quickly and successfully. […] For every million doses of the vaccine given, there are only about three cases of anaphylaxis. This is a similar rate for other vaccines given to children.

• #64 Human papillomavirus (HPV) and immunisation | Better Health Channel

  https://www.betterhealth.vic.gov.au/health/healthyliving/human-papillomavirus-hpv-immunisation

  Many people with HPV do not experience symptoms. The virus can clear from your body without your knowledge. […] Although symptoms of HPV can be vague, see your doctor or sexual health clinic if you have: unusual vaginal or anal bleeding, pain during sex, lumps, pain or itching in your genital area. […] Common side effects following immunisation are usually mild and temporary. Side effects after HPV vaccination are usually mild and get better on their own. […] Side effects may include: pain, redness and swelling at the injection site, low-grade temperature (fever), mild headache, mild nausea. […] If you experience fever after your HPV immunisation, try to: drink extra fluids, don’t overdress/wear light clothing, take paracetamol (check the label for the correct dose or speak with your pharmacist if you’re unsure how to take paracetamol).

• #65 HPV (human papillomavirus) vaccine – what you need to know: MedlinePlus Medical EncyclopediaLock

  https://medlineplus.gov/ency/article/007648.htm

  HPV vaccine may be given to adults 27 through 45 years of age, based on discussions between the patient and health care provider. […] Risks of a vaccine reaction include soreness, redness, or swelling where the shot is given can happen after HPV vaccination. […] Fever or headache can happen after HPV vaccination. […] People sometimes faint after medical procedures, including vaccination. […] As with any medicine, there is a very remote chance of a vaccine causing a severe allergic reaction, other serious injury, or death. […] An allergic reaction could occur after the vaccinated person leaves the clinic. If you see signs of a severe allergic reaction (hives, swelling of the face and throat, difficulty breathing, a fast heartbeat, dizziness, or weakness), call 9-1-1 or your local emergency number and get the person to the nearest hospital.

• #66 Human papillomavirus vaccine (intramuscular route) – Mayo Clinic

  https://www.mayoclinic.org/drugs-supplements/human-papillomavirus-vaccine-intramuscular-route/description/drg-20127679

  Human papillomavirus (HPV) vaccine helps prevent anal, cervical, vulvar, vaginal, oropharyngeal (mouth and throat), or head and neck cancer, genital warts, and abnormal or precancerous diseases of the anus, cervix, vagina, and vulva in girls and women 9 to 45 years of age. […] This vaccine may cause a serious type of allergic reaction called anaphylaxis, which can be life-threatening and requires immediate medical attention. Tell your doctor right away if you or your child has a rash, itching, swelling of the tongue and throat, or trouble with breathing after you get the injection. […] You or your child may feel faint, lightheaded, or dizzy right after you receive this vaccine. Sitting or lying down for 15 minutes after you receive the vaccine may help. If any of these side effects occur, do not drive or do anything else that could be dangerous until you know how this medicine affects you.

• #67 Human Papillomavirus Vaccine (9-Valent | Memorial Sloan Kettering Cancer Center

  https://www.mskcc.org/cancer-care/patient-education/medications/adult/human-papillomavirus-vaccine-9-valent

  This drug may interact with other drugs or health problems. […] Like all vaccines, this vaccine may not fully protect all people who get it. If you have questions, talk with the doctor. […] WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect: […] These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects. […] All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away: […] If your symptoms or health problems do not get better or if they become worse, call your doctor.

• #68 HPV Vaccine Side Effects You Should Know About | LifeMD

  https://lifemd.com/learn/hpv-vaccine-side-effects-you-should-know-about

  HPV vaccine can cause side effects. However, the side effects are usually mild and go away on their own within a few days. […] In very rare cases, serious allergic reactions may occur. Symptoms of anaphylaxis may include difficulty breathing, swelling of the face or throat, rapid heartbeat, and dizziness. […] It’s important to seek medical attention right away if you experience any of these symptoms after you’ve received the HPV vaccine. Severe allergic reactions can be life-threatening and require professional care to prevent serious consequences.

• #69 HPV Vaccine Side Effects | Most Common Is Soreness of Injection Area

  https://www.hpv.org.nz/hpv-prevention/hpv-vaccine-side-effects

  Are there any HPV vaccine side effects? The HPV vaccine is very safe for everyone, and no different from other common vaccines. The most common side effect is soreness at the injection site. […] As with all immunisations, people may have a sore arm and get redness, pain and swelling at the injection site. Other possible reactions that can occur, usually within 12 days, include: a fever (feeling hot), headache, general discomfort (feeling unwell, aches and pains), skin reaction, rash. Very rarely, a serious allergic reaction (like a peanut allergy) called anaphylaxis occurs, usually within 10 minutes of immunisation. Anaphylaxis can occur with any medicine or vaccine. If anaphylaxis does occur, it can be treated. For this reason, children are asked to wait for 20 minutes after immunisation. Every vaccinator is trained and equipped to deal with such a reaction.

• #70 HPV vaccine | NHS inform

  https://www.nhsinform.scot/healthy-living/immunisation/vaccines/hpv-vaccine/

  The HPV vaccine does not protect against all types of HPV that can cause cancer. You’ll still need to go for regular cervical screening (smear tests) when you reach 25 years of age. […] Like all medicines, vaccines can cause side effects. This is normal but not everyone gets them. […] The most common side effects of the HPV vaccine usually happen where you had the injection. These can include: soreness, swelling, redness, bruising, itching. […] Other common side effects include: fever, sickness, dizziness, headache. […] If you do experience any of these side effects, they’ll wear off after a couple of days. […] Very rarely, some people have a severe reaction (anaphylactic reaction) soon after vaccination. This causes breathing difficulties and may cause them to collapse. These reactions are extremely rare. The person giving you your vaccine is fully trained to deal with them.

• #71 HPV vaccine safety and side effects

  https://www.hpvvaccine.org.au/hpv-vaccine/hpv-vaccine-safety-and-side-effects

  All health problems that occur after vaccines are monitored on an ongoing basis in Australia and internationally. This is to establish whether they were caused by the vaccine or occurred coincidentally around the time of vaccination. […] For this reason, it’s important to report any reactions you have after having the HPV vaccine to the person who gave you the injection or to your doctor.

• #72 Parent Concerns About HPV Vaccine Safety Increasing – NCI

  https://www.cancer.gov/news-events/cancer-currents-blog/2021/hpv-vaccine-parents-safety-concerns

  Despite more than 15 years of consistent evidence that HPV vaccines are safe and effective, a new study has found that more parents are citing concerns about the vaccines safety in recent years. […] During the same time frame, reports of serious health issues after HPV vaccination were consistently rare, the study found. […] HPV vaccines can cause pain, swelling, and redness where the shot was given, as well as headaches, tiredness, and nausea. The most common serious side effects of HPV vaccination are dizziness and fainting. There is no evidence that HPV vaccines lead to infertility or autoimmune diseases, although these are common myths. […] In 2015, 13% of parents had cited safety concerns as the main reason for declining the HPV vaccine. But by 2018, that percentage had risen to 23%. […] Reports of serious health issues after HPV vaccination were consistently rarearound 1.8 per 100,000 HPV vaccine doses, or 0.0018%. A total of 758 serious health problems that arose after HPV vaccination were reported in VAERS during that time.

• #73 Human papillomavirus (HPV) vaccines: Canadian Immunization Guide – Canada.ca

  https://www.canada.ca/en/public-health/services/publications/healthy-living/canadian-immunization-guide-part-4-active-vaccines/page-9-human-papillomavirus-vaccine.html

  Globally and in Canada, HPV-associated diseases are a significant public health problem. […] The most commonly reported adverse events following HPV vaccination are injection site pain, swelling or redness. […] HPV vaccine prevents abnormal Pap smears and HPV-associated cancers, including cervical and anal cancers. […] HPV vaccination after the onset of sexual activity is beneficial because the vaccine recipient is very unlikely to be infected with all HPV types in the vaccine. […] Serious adverse events are rare following HPV immunization and, in most cases, data are insufficient to determine a causal association. […] The most common local adverse events in persons receiving HPV vaccines were: injection site pain, swelling and redness. The most common systemic adverse events were headache, fever (37.8C), and nausea.

• #74 HPV (human papillomavirus) vaccine | Australian Government Department of Health and Aged Care

  https://www.health.gov.au/topics/immunisation/vaccines/human-papillomavirus-hpv-immunisation-service

  HPV vaccines come as a single vaccine, not as a combination vaccine. […] You may experience minor side effects following vaccination. Most reactions are mild and last no more than a couple of days and you will recover without any problems. […] Common side effects of HPV vaccines include: pain, redness and swelling at injection site, mild fever, mild headache, mild nausea. […] Talk to your vaccination provider about possible side effects of HPV vaccines, or if after having a HPV vaccine you or your child have symptoms that worry you. […] The Consumer Medicine Information available on the Therapeutic Goods Administration website lists the ingredients and side effects of each vaccine.

• #75 HPV vaccine safety and side effects

  https://www.hpvvaccine.org.au/hpv-vaccine/hpv-vaccine-safety-and-side-effects

  The HPV vaccination has been offered continuously under Australia’s National Immunisation Program since 2007. […] Side effects after receiving the HPV vaccine are usually only very mild. The reactions that people have had after the HPV vaccine are similar to reactions from other vaccines which include pain, redness and swelling at the site of the injection. […] These symptoms occur in about four in five cases and should go away quickly. They can be treated with an ice pack or paracetamol if needed. […] People are monitored for 15 minutes after having the HPV vaccine. If an allergic reaction or, more rarely, a more serious allergic reaction called anaphylaxis, does occur, it can be treated quickly and successfully. […] For every million doses of the vaccine given, there are only about three cases of anaphylaxis. This is a similar rate for other vaccines given to children.

• #76

  https://www.who.int/groups/global-advisory-committee-on-vaccine-safety/topics/human-papillomavirus-vaccines/safety

  Since licensure in 2006, over 270 million doses of HPV vaccines have been distributed. GACVS first reviewed the safety data in 2007, and subsequently in 2008, 2009, 2013, 2014, and 2015. Early on, the Committee was presented signals related to anaphylaxis and syncope. The risk of anaphylaxis has been characterized as approximately 1.7 cases per million doses, and syncope was established as a common anxiety or stress-related reaction to the injection. No other adverse reactions have been identified and GACVS considers HPV vaccines to be extremely safe. […] In addition, GACVS was presented with new studies assessing other safety concerns, again from the US, as well as from Denmark. These studies included examination of specific outcomes that included complex regional pain syndrome (CRPS), postural orthostatic tachycardia syndrome (POTS), premature ovarian insufficiency, primary ovarian failure, and a further look at the risk of venous thromboembolism. With now large population level data from several countries, the Committee saw no new evidence for a causal association between HPV vaccine and those conditions.

• #77

  https://www.bumrungrad.com/en/health-blog/january-2024/q-a-cervical-cancer

  1. Common side effects are soreness, swelling, redness, headache, itching, bruising, hematoma lump, fever, nausea, dizziness, and fatigue. They are mostly mild and go away on their own 3-5 days after vaccination, and medicines to relieve symptoms can be used. […] 14. Is the HPV vaccine safe? Answer: It is safe. According to the survey data on more than 300 million doses that have been administered worldwide, it causes mostly mild side effects and no vaccine-related death is reported. This is because the current HPV vaccines are based on virus-like particles (VLPs). The VLPs are not infectious because they lack the virus’s DNA and thus cannot cause an HPV infection or a disease.

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