Wrzody i karbunkuły
Etiologia i przyczyny
Wrzody (furunkuły) i karbunkuły to głębokie zakażenia skóry, najczęściej wywołane przez Staphylococcus aureus, w tym szczepy metycylinooporne (MRSA), które stanowią wyzwanie terapeutyczne ze względu na oporność na antybiotyki. Furunkuł definiuje się jako zakażenie pojedynczego mieszka włosowego, natomiast karbunkuł to skupisko połączonych wrzodów, prowadzące do rozległego, głębokiego stanu zapalnego z obecnością ropy. Czynniki predysponujące obejmują m.in. cukrzycę, zaburzenia odporności, choroby skóry (egzema, łuszczyca), nosicielstwo S. aureus, otyłość, niedożywienie oraz stosowanie leków immunosupresyjnych i przewlekłą sterydoterapię. Nawracające wrzody (furunkuloza) mogą wskazywać na obecność szczepu PVL S. aureus, co zwiększa ryzyko powikłań. Diagnostyka powinna obejmować badania mikrobiologiczne z określeniem lekowrażliwości, zwłaszcza w przypadku nawracających lub opornych zakażeń.
Etiologia, przyczyny i patogeneza wrzodów i karbunkułów
Wrzody i karbunkuły to zakażenia skóry wywoływane przede wszystkim przez bakterie. Wrzód (furunkuł) definiowany jest jako głębokie zakażenie mieszka włosowego, natomiast karbunkuł stanowi skupisko połączonych ze sobą wrzodów tworzących większy obszar zakażenia pod powierzchnią skóry.123
Czynniki etiologiczne
Głównym czynnikiem etiologicznym wrzodów i karbunkułów jest bakteria Staphylococcus aureus (gronkowiec złocisty), powszechnie występująca na powierzchni skóry oraz w błonie śluzowej nosa i gardła.134 U większości osób bakteria ta stanowi naturalną florę skóry i nie wywołuje zakażeń, dopóki nie wniknie przez uszkodzoną barierę skórną.4 Warto podkreślić, że chociaż gronkowiec złocisty jest dominującym patogenem, to wrzody i karbunkuły mogą być również wywołane przez inne bakterie, a w rzadkich przypadkach nawet przez grzyby.25
Coraz częściej obserwuje się zakażenia wywoływane przez szczepy metycylinooporne Staphylococcus aureus (MRSA), które charakteryzują się opornością na wiele powszechnie stosowanych antybiotyków, co znacznie utrudnia leczenie.678 W przypadku nawracających zakażeń, szczególnie w okolicy anogenitalnej, mogą być one wywoływane przez bakterie beztlenowe.8
Mechanizm powstawania zakażenia
Rozwój wrzodu rozpoczyna się, gdy bakterie przenikają przez barierę skórną do mieszka włosowego.9 Do uszkodzenia skóry może dojść w wyniku:94
- Drobnych zranień, zadrapań lub otarć
- Ukłuć owadów
- Ciała obcego tkwiącego w skórze (np. drzazgi)
- Golenia lub innych metod usuwania włosów
- Zatkanych gruczołów potowych
Po wniknięciu bakterii do mieszka włosowego, układ odpornościowy reaguje wysyłając białe krwinki do obszaru zakażenia w celu zniszczenia patogenów. To prowadzi do powstania stanu zapalnego i gromadzenia się ropy, która jest mieszaniną martwych bakterii, białych krwinek i martwej tkanki.4 W efekcie formuje się bolesny, wypełniony ropą guzek pod skórą.1
Karbunkuł powstaje, gdy zakażenie obejmuje wiele sąsiadujących mieszków włosowych, które łączą się ze sobą, tworząc większy, głębszy i bardziej rozległy obszar zakażenia.39 Karbunkuły często mają wiele „główek” ropnych i powodują głębsze oraz poważniejsze zakażenie niż pojedyncze wrzody.1314
Czynniki ryzyka
Choć wrzody i karbunkuły mogą wystąpić u każdego, w tym u osób zdrowych, istnieje szereg czynników zwiększających ryzyko ich rozwoju:157
Choroby współistniejące
- Cukrzyca – choroba ta zaburza zdolność organizmu do zwalczania zakażeń, w tym bakteryjnych zakażeń skóry31617
- Zaburzenia odporności – osoby z osłabionym układem immunologicznym są bardziej podatne na rozwój zakażeń skórnych181920
- Choroby skóry – schorzenia takie jak wyprysk (egzema), trądzik czy łuszczyca uszkadzają barierę ochronną skóry, ułatwiając wnikanie bakterii2122
- Przewlekłe choroby – schorzenia nerek, wątroby, niewydolność serca2023
Czynniki osobnicze
- Nosicielstwo S. aureus – osoby będące nosicielami gronkowca złocistego w nosie, gardle lub na skórze są bardziej narażone na rozwój wrzodów2425
- Wiek – wrzody są rzadko spotykane u dzieci, najczęściej występują u nastolatków i młodych dorosłych, natomiast karbunkuły częściej dotykają osoby w średnim wieku1526
- Płeć – mężczyźni są bardziej podatni na rozwój karbunkułów26
- Otyłość – zwiększa ryzyko rozwoju wrzodów i karbunkułów67
- Niedożywienie – niedobory żywieniowe, szczególnie witamin A i E27
Czynniki środowiskowe
- Niedostateczna higiena – sprzyja namnażaniu się bakterii na skórze628
- Bliski kontakt z osobą zakażoną – bakterie mogą być przenoszone przez kontakt bezpośredni lub przez wspólne użytkowanie przedmiotów osobistych (ręczniki, ubrania, przybory toaletowe)2129
- Środowiska sprzyjające rozprzestrzenianiu się zakażeń – miejsca zatłoczone, takie jak akademiki, koszary wojskowe630
- Gorący i wilgotny klimat – sprzyja rozwojowi bakterii na skórze7
- Nadmierne pocenie się i tarcie mechaniczne skóry – szczególnie w fałdach skórnych i miejscach narażonych na otarcia3132
Czynniki farmakologiczne
- Leki immunosupresyjne – stosowane np. w chemioterapii, po przeszczepach33
- Przewlekła sterydoterapia – osłabia miejscową odporność skóry20
- Wcześniejsze stosowanie antybiotyków – może prowadzić do zaburzenia naturalnej flory bakteryjnej skóry34
- Niektóre leki (kortykostreoidy, androgeny, lit) mogą przyczyniać się do rozwoju zapalenia mieszków włosowych12
Szczególne postacie wrzodów
Furunkuloza to termin określający nawracające lub mnogie wrzody.17 Istnieje kilka czynników zwiększających ryzyko furunkulozy:34
- Młodszy wiek (poniżej 30 lat)
- Nosicielstwo bakterii S. aureus
- Cukrzyca
- Otyłość
- Palenie tytoniu
- Przyjmowanie antybiotyków w ciągu sześciu miesięcy przed wystąpieniem wrzodów
Nawracające wrzody mogą wskazywać na obecność konkretnego szczepu gronkowca – PVL Staphylococcus (wytwarzającego leukocydynę Pantona-Valentine’a) – u pacjenta lub członków jego rodziny. Osoby z tym szczepem bakterii są bardziej podatne na infekcje skórne i wrzody.24
Powikłania wrzodów i karbunkułów
W rzadkich przypadkach, bakterie z wrzodów lub karbunkułów mogą przedostać się do krwiobiegu, powodując poważne powikłania:6911
- Posocznica (sepsa) – ogólnoustrojowa reakcja na zakażenie krwi
- Zapalenie wsierdzia – zakażenie wyściółki serca
- Zapalenie szpiku kostnego (osteomyelitis) – zakażenie kości
- Ropnie w różnych narządach (mózg, rdzeń kręgowy, skóra, narządy wewnętrzne)
- Zapalenie tkanki łącznej (cellulitis) – rozprzestrzenienie się zakażenia na okoliczne tkanki miękkie
- Trwałe blizny
Ryzyko powikłań jest wyższe w przypadku karbunkułów ze względu na ich głębszy i bardziej rozległy charakter w porównaniu z pojedynczymi wrzodami.3435
Diagnostyka różnicowa wrzodów i karbunkułów
Przy nawracających wrzodach (furunkulozie) wskazane jest przeprowadzenie diagnostyki w kierunku czynników predysponujących. Lekarz może zlecić badania laboratoryjne w celu wykluczenia:1624
- Cukrzycy
- Niedoborów immunologicznych
- Zaburzeń hematologicznych
- Nosicielstwa szczególnie wirulentnych szczepów S. aureus
W przypadku trudno leczących się lub nawracających wrzodów zaleca się pobranie materiału do badania mikrobiologicznego i określenia lekowrażliwości, zwłaszcza w kierunku MRSA.3637 W niektórych przypadkach konieczne może być pobranie wymazów z nosa, pach, odbytu i okolic narządów płciowych w celu zidentyfikowania nosicielstwa gronkowca.37
Wrzody i karbunkuły należy różnicować z innymi zmianami skórnymi takimi jak:3535
- Ropne zapalenie mieszków włosowych (folliculitis)
- Ropnie podskórne o innej etiologii
- Hidradenitis suppurativa (HS) – przewlekłe zapalne schorzenie skóry z nawracającymi zmianami w okolicach pachwin, pach i pod piersiami38
- Zmiany nowotworowe skóry
- Torbiele skórne
Dokładna diagnostyka jest szczególnie istotna w przypadku nawracających lub nietypowo przebiegających zakażeń, gdyż mogą one sygnalizować obecność poważniejszych schorzeń ogólnoustrojowych.16
Kolejne rozdziały
Zapraszamy do dalszego czytania naszego leksykonu.
Wybierz kolejny rozdział z menu poniżej, aby otworzyć nową podstronę kompedium wiedzy i uzyskać szczegółowe informację o leku, substancji lub chorobie.
Materiały źródłowe
- #1 Boils and carbuncles // Middlesex Healthhttps://middlesexhealth.org/learning-center/diseases-and-conditions/boils-and-carbuncles
A boil is a painful, pus-filled bump that forms under your skin when bacteria infect and inflame one or more of your hair follicles. […] A carbuncle is a cluster of boils that form a connected area of infection under the skin. […] Most boils are caused by Staphylococcus aureus, a type of bacterium commonly found on the skin and inside the nose. A bump forms as pus collects under the skin. […] Boils sometimes develop at sites where the skin has been broken by a small injury or an insect bite, which gives the bacteria easy entry.
- #2 Boils & Carbuncles: Symptoms, Treatment & Preventionhttps://my.clevelandclinic.org/health/diseases/15153-boils-and-carbuncles
A boil is a skin infection that is usually caused by the bacteria Staphylococcus aureus (staph). […] Boils are usually caused by the bacteria Staphylococcus aureus (staph infection), but other bacteria and fungi can cause them too. […] The infection is deeper and more severe than one boil.
- #3 Overview: Boils and carbuncles – InformedHealth.org – NCBI Bookshelfhttps://www.ncbi.nlm.nih.gov/books/NBK513141/
A boil (furuncle) is a pus-filled bump in the skin that is caused by a bacterial infection. […] Boils are caused by bacteria, most commonly by Staphylococcus aureus bacteria (a staph infection). […] They are more likely to lead to boils or other skin infections in people who have weakened immune systems. […] For this reason, boils are more common in people with medical conditions such as diabetes, chronic infections or cancer. […] Boils develop when a hair follicle and the surrounding tissue become infected. […] If several boils merge into a larger bump, its called a carbuncle. […] If several boils develop in neighboring hair follicles and merge into a larger connected area of infection under the skin, its called a carbuncle. […] Antibiotics are only needed if complications are likely or have already occurred for instance, if several boils have merged and developed into a carbuncle.
- #4 Carbuncle: Symptoms, causes, treatment, and morehttps://www.medicalnewstoday.com/articles/185421
Furuncles and carbuncles typically happen as a result of staphylococcal infection. They develop when the infection affects the hair follicle and surrounding tissue. This can cause some swelling and other symptoms. […] Staphylococcal infection usually causes carbuncles. They develop when the infection causes boils to develop in the hair follicles and surrounding tissues. […] Staphylococcus aureus (S. aureus), also known as staph bacteria, lives on the skin and inside the nose and throat. Usually, the body’s immune system keeps them under control, but sometimes they enter the skin through a hair follicle, or through a cut or graze in the skin. […] When the skin becomes infected, the immune system responds by sending white blood cells to the affected area to destroy the bacteria. Pus is an accumulation of dead bacteria, dead white blood cells, and dead skin. […] This can result in a boil, which can cluster together to form a carbuncle.
- #5 Carbuncle – Symptoms, Causes, Treatmentshttps://resources.healthgrades.com/right-care/skin-hair-and-nails/carbuncle
A carbuncle is a group of boils (infections associated with hair follicles) on the skin. A carbuncle forms when a number of boils group together to form one lump, or when multiple hair follicles become infected at once. […] Carbuncles are typically triggered by bacterial infection of the hair follicles, usually by Staphylococcus aureus bacteria, but other bacteria and fungi present on the skin surface may also cause the infection. […] The exact reason why these infections develop is not known, but people with conditions that compromise the immune system are more susceptible to the development of boils and carbuncles. […] A carbuncle develops when multiple hair follicles become infected by bacteria or fungus from the skin. Staphylococcus aureus is the type of bacteria most commonly associated with boils and carbuncles.
- #6 Carbuncles: Causes, Symptoms, and Treatmentshttps://www.webmd.com/skin-problems-and-treatments/carbuncles-causes-treatments
Most carbuncles are caused by Staphylococcus aureus bacteria, which inhabit the skin surface, throat, and nasal passages. […] Sometimes, carbuncles are caused by methicillin-resistant Staphylococcus aureus (MRSA) bacteria, and require treatment with potent prescription antibiotics if the lesions are not drained properly. […] In rare cases, bacteria from a carbuncle can escape into the bloodstream and cause serious complications, including sepsis and infections in other parts of the body such as the lung, bones, joints, heart, blood, and central nervous system. […] Older age, obesity, poor hygiene, and poor overall health are associated with carbuncles. Other risk factors for carbuncles include chronic skin conditions, which damage the skin’s protective barrier, diabetes, kidney disease, liver disease, and any condition or treatment that weakens the immune system. […] Carbuncles also can occur in otherwise healthy, fit, younger people, especially those who live together in group settings such as college dorms and share items such as bed linens, towels, or clothing.
- #7 Furuncles and Carbuncles – Dermatologic Disorders – Merck Manual Professional Editionhttps://www.merckmanuals.com/professional/dermatologic-disorders/bacterial-skin-infections/furuncles-and-carbuncles
Furuncles (boils) are skin abscesses caused by staphylococcal infection, which involve a hair follicle and surrounding tissue. […] Carbuncles are clusters of furuncles connected subcutaneously, causing deeper suppuration and scarring. […] Both furuncles and carbuncles may affect healthy young people but are more common among people who have obesity, are immunocompromised (including those with neutrophil defects), are older, and possibly those who have diabetes. […] Predisposing factors include bacterial colonization of skin or nares, hot and humid climates, and occlusion or abnormal follicular anatomy (eg, comedones in acne). […] Methicillin-resistant Staphylococcus aureus (MRSA) is a common cause. […] Furuncles frequently recur and can be prevented by applying liquid soap containing either chlorhexidine gluconate with isopropyl alcohol or 2 to 3% chloroxylenol. […] Patients with recurrent furunculosis should be treated for predisposing factors such as obesity, diabetes, occupational or industrial exposure to inciting factors, and nasal carriage of S. aureus or MRSA colonization.
- #8 Carbuncle – StatPearls – NCBI Bookshelfhttps://www.ncbi.nlm.nih.gov/books/NBK554459/
Bacterial infection within the hair follicle causes carbuncles. The most common causative organism is Staphylococcus aureus and frequently involves methicillin-resistant Staphylococcus aureus. […] Occasionally, carbuncles can be caused by anaerobic bacteria, especially in cases that are recurrent and involve the anogenital region. […] Staphylococcus aureus can normally be found on intact skin most commonly in intertriginous areas such as the groin, axilla, buttocks, and neck. […] It can also be present in the nares. […] Staphylococcus aureus can be transferred to other anatomical locations by scratching. […] When the skin barrier is broken down or disrupted, bacteria can inoculate the hair follicle. […] Once inoculated, the bacteria can proliferate and lead to folliculitis, furuncle, and/or carbuncle.
- #9 Boils: Pictures on Skin, Causes, and Treatmenthttps://www.webmd.com/skin-problems-and-treatments/ss/slideshow-boils
A boil is a common, painful infection of a hair follicle and the surrounding skin. […] Most boils are caused by staph bacteria (Staphylococcus aureus), which many healthy people carry on their skin or in their noses without a problem. When a scrape, cut, or splinter breaks the skin, the bacteria can enter a hair follicle and start an infection. […] When several boils form close together and join beneath the skin, it’s called a carbuncle. […] A carbuncle tends to lie deeper beneath the skin than a boil and can take longer to heal. […] Rarely, the staph bacteria from a boil or carbuncle can get into the bloodstream, which can then affect the heart and other internal organs.
- #10 Boils (Skin Abscesses) Pictures, Treatment, Causes, Symptomshttps://www.medicinenet.com/boils/article.htm
Boils (Skin Abscesses) The bacteria that cause boils are contagious, and skin infections can be spread from contact with the fluid. […] A boil is a localized infection in the skin that begins as a reddened, tender area. […] Several different types of boils include the following: Furuncle or carbuncle: This is an abscess in the skin usually caused by an infection with the bacterium Staphylococcus aureus. […] There are many causes of boils. Some boils can be caused by ingrown hair. Others can form as the result of a splinter or other foreign material that has become lodged in the skin. Other boils, such as acne, are caused by plugged sweat glands that become infected. […] The skin is an essential part of our immune defense against materials and microbes that are foreign to our bodies. Any break in the skin, such as a cut or scrape, can develop into an abscess should it become infected with bacteria.
- #11 Boils (Skin Abscesses) Pictures, Treatment, Causes, Symptomshttps://www.medicinenet.com/boils/article.htm
However, people with certain illnesses or who take certain medications that weaken the body’s immune system (the natural defense system against foreign materials or microbes) are more likely to develop boils. […] Diseases that are associated with impaired immune systems include diabetes and kidney failure. […] Many medications can suppress the normal immune system and increase the risk of developing boils and other infections. […] Boils are infections of the skin caused by bacteria. […] Complications of boils include the formation of a larger abscess, a worsening or spreading of infection to adjacent areas of skin or soft tissue (cellulitis), and very rarely, the spread of the infection through the bloodstream to sites elsewhere in the body. […] Sometimes a boil may be caused by an organism typically associated with more serious infections, such as methicillin-resistant Staphylococcus aureus (MRSA), with a risk of spreading this infection from a staph boil to deeper tissues. […] Recurrence of the infection is another possible complication, which is more likely in certain types of boils.
- #12 Folliculitis and furuncles / carbuncles (boils)https://www.pcds.org.uk/clinical-guidance/folliculitis-an-overview
Folliculitis can be due to infection, occlusion, or irritation of the hair follicles and as part of the clinical presentation of a number of other skin conditions. […] A furuncle (syn. boil) is a deeper, and more pronounced infection of the hair follicle in which purulent material extends through the dermis into the subcutaneous tissue, where a small abscess forms. A carbuncle is a coalescence of several inflamed follicles into a single inflammatory mass with purulent drainage from multiple follicles. […] Deep folliculitis tends to be infective. […] The most common infection is staphylococcus aureus, although other organisms can be involved. […] Pseudofolliculitis can result from shaving and other forms of hair removal. […] Occlusion folliculitis can result from the use of emollients and topical steroids in the treatment of a number of skin conditions, eg eczema. […] Folliculitis may be due to medications such as corticosteroids, androgens and lithium. […] The most common bacterial infection is staphylococcus aureus. […] Many will resolve with an appropriate antibiotic eg flucloxacillin or erythromycin / clarithromycin.
- #13 What Is a Carbuncle? Symptoms, Treatment, and Morehttps://www.verywellhealth.com/carbuncle-8770485
A carbuncle is a dome-shaped grouping of large and painful boils (swollen, irritated bumps) that form together to create a larger area of infection. They are much deeper and more severe than a single boil. Boils and carbuncles form when bacteria on the surface of the skin invade hair follicles. […] The most common cause of a carbuncle is a bacterial infection caused by the Staphylococcus aureus bacteria, also known as a staph infection. Methicillin-resistant S. aureus (MRSA), which is resistant to some common antibiotics, is also becoming a common cause of carbuncles. In some cases, the cause of the carbuncle is not easily identifiable. […] Certain risk factors can drive the development of carbuncles, including: friction in the area caused by clothing or shaving, poor personal hygiene, poor overall health and existing medical conditions, including diabetes, dermatitis, and a weakened immune system.
- #14 Carbuncle | Boils, Furuncles, Abscesses | Britannicahttps://www.britannica.com/science/carbuncle-skin-infection
carbuncle, in medicine, a type of inflammatory staphylococcal infection of the skin. A carbuncle typically consists of two or more interconnected boils called furuncles; these are painful red nodules that form yellowish heads which burst to release pus and dead tissue. […] Carbuncles, however, are larger than furuncles, generally involve deeper layers of the skin, and have multiple openings for the drainage of pus. […] They occur most often in hairy skin areas or areas that are subject to friction e.g., the back of the neck, the armpits, and the buttocks. […] While simple boils can be eliminated by the application of hot, moist dressings followed by washing with soap, carbuncles may have to be lanced and drained, a procedure that is often followed by antibiotic treatment. […] After the treatment, poor hygiene may lead to a recurrence.
- #15 Boils, Carbuncles and Furunculosis | Causes and Treatmenthttps://patient.info/skin-conditions/boils-carbuncles-and-furunculosis
A boil (furuncle) is an infection of a hair follicle. A carbuncle occurs when a group of hair follicles next to each other become infected. It is like a multiple boil. Chronic furunculosis is a condition where you have crops of boils that occur over a longer period of time. […] A boil or carbuncle can occur in anyone at any age. However, they are uncommon in children and most common in teenagers and young adults. You have a higher risk of developing a boil or carbuncle if you: […] Boils are caused by germs (bacteria) multiplying below the skin surface. […] Your immune system is important in helping you to fight off infection. […] That means you have a higher risk of developing a boil or carbuncle if germs get under your skin and your immune system does not kill them quickly enough to stop them multiplying.
- #16 Boils and carbuncles Guide: Causes, Symptoms and Treatment Optionshttps://www.drugs.com/health-guide/boils-and-carbuncles.html
Boils and carbuncles are skin infections usually caused by Staphylococcus aureus bacteria (staph). […] A carbuncle is a deeper skin infection that involves a group of infected hair follicles in one skin location. […] People with diabetes are more likely to develop carbuncles. […] If you get several boils within a short period of time, your doctor may do blood tests to check for diabetes or other medical conditions that can increase your risk of repeated infections. […] If you have had several episodes of boils within a short period of time, visit your doctor. Your doctor can check whether an undiagnosed medical illness is affecting your body’s ability to fight infections.
- #17 Boils | Better Health Channelhttps://www.betterhealth.vic.gov.au/health/conditionsandtreatments/boils
A boil is an infection of a hair follicle, caused by the bacterium Staphylococcus aureus. […] A carbuncle is an aggregate of connected furuncles and has several pustular openings. […] Certain factors make a person more susceptible to outbreaks of boils, including: Diabetes recurring boils may be symptomatic of uncontrolled diabetes, especially for people aged over 40 years. […] Staphylococcus bacteria can cause a range of infections, from relatively mild to severe and life threatening. […] Furunculosis refers to recurring outbreaks of boils.
- #18 Carbuncle – UF Healthhttps://ufhealth.org/conditions-and-treatments/carbuncle
A carbuncle is a skin infection that often involves a group of hair follicles. The infected material forms a lump, which occurs deep in the skin and often contains pus. […] Most carbuncles are caused by the bacteria Staphylococcus aureus (S aureus). […] The bacteria that cause this condition spread easily. So, family members may develop carbuncles at the same time. Often, the cause of a carbuncle cannot be determined. […] People with diabetes, dermatitis, and a weakened immune system are more likely to develop staph infections that can cause carbuncles. […] Staph bacteria are sometimes found in the nose or around the genitals. Carbuncles can recur when antibiotics are not able to treat the bacteria in those areas.
- #19 Boils and Carbuncles | Doctorhttps://patient.info/doctor/boils-and-carbuncles
A boil (furuncle) is an acute infection of a hair follicle, usually caused by Staphylococcus aureus. […] A carbuncle is a swollen, painful area discharging pus from several points. It occurs when a group of adjacent hair follicles becomes deeply infected; S. aureus is usually the pathogen. […] The source of staphylococcal infection is usually in the nose or the perineum and it is thought that the infection is disseminated by the fingers and by clothing. […] There is usually no predisposing cause, although boils may complicate atopic dermatitis, excoriations, abrasions, scabies or pediculosis. Staphylococcal colonisation is more common on atopic eczema and may contribute to the pathogenesis. […] The evidence to link diabetes with furunculosis (multiple crops of boils) is conflicting but when boils affect people with diabetes, they tend to be more extensive.
- #20 Boils and Carbuncles | Doctorhttps://patient.info/doctor/boils-and-carbuncles
Other conditions associated with furunculosis include obesity and immune compromise, as with HIV, blood dyscrasias and treatment with immunosuppressive drugs. […] Carbuncles are associated with malnutrition, heart failure, drug addiction, severe generalised skin disease and prolonged steroid therapy. […] The evidence is conflicting with regard to association with diabetes.
- #21 Boils and carbuncleshttps://www.ldc-phila-vic.org/Member-Benefits/health/conditions/boils-and-carbuncles.cfm
A boil is a painful, pus-filled bump that forms under your skin when bacteria infect and inflame one or more of your hair follicles. A carbuncle is a cluster of boils that form a connected area of infection under the skin. […] Most boils are caused by Staphylococcus aureus, a type of bacterium commonly found on the skin and inside the nose. A bump forms as pus collects under the skin. Boils sometimes develop at sites where the skin has been broken by a small injury or an insect bite, which gives the bacteria easy entry. […] Although anyone including otherwise healthy people can develop boils or carbuncles, the following factors can increase your risk: Close contact with a person who has a staph infection. You’re more likely to develop an infection if you live with someone who has a boil or carbuncle. Diabetes. This disease can make it more difficult for your body to fight infection, including bacterial infections of your skin. Other skin conditions. Because they damage your skin’s protective barrier, skin problems, such as acne and eczema, make you more susceptible to boils and carbuncles. Compromised immunity. If your immune system is weakened for any reason, you’re more susceptible to boils and carbuncles.
- #22 Carbuncle: Symptoms, Causes, Diagnosis, Treatmenthttps://www.health.com/carbuncle-8605330
Anyone can develop a carbuncle, but certain factors can increase your risk. These include poor hygiene, being immunocompromised (having a weakened immune system), underlying conditions, such as eczema, diabetes, alcohol use disorder, and obesity, direct contact with a person who has a staph infection, and living in crowded conditions.
- #23 What Is a Carbuncle?https://www.horvathdermatology.com/blog/446504-what-is-a-carbuncle/
A boil is an infection of the hair follicle that develops under the skin. When multiple boils develop this is known as a carbuncle. […] Most of the time, bacteria known as staphylococcus aureus are to blame for carbuncles. This bacteria is already present on the skin, but can easily get into a hair follicle through a cut or opening. […] There are many risk factors that can cause someone to be prone to carbuncles. These risk factors include: Chronic skin problems, Older age, Obesity, Poor hygiene, Liver disease, Diabetes, A weakened immune system. […] Of course, people donât have to have these risk factors to develop this skin infection. Many health individuals deal with this issue too.
- #24 Boils, Carbuncles and Furunculosis | Causes and Treatmenthttps://patient.info/skin-conditions/boils-carbuncles-and-furunculosis
If you develop recurring boils (chronic furunculosis), your doctor may suggest some tests to look for an underlying cause. […] One cause of recurring boils if you are otherwise healthy is that you, or someone in your family or household, may be a carrier of a special type of staphylococcal germ (bacteria), which is called PVL staphylococcus. This means that a certain number of these bacteria live harmlessly on your skin, or in your nose. If you are a carrier, you tend to be more prone to skin infections and boils. In particular, these bacteria may quickly invade and multiply in broken skin following a minor cut or injury.
- #25 Boils (furunculosis)https://dermnetnz.org/topics/boil
A boil (also called a furuncle) is a deep form of bacterial folliculitis (infection of a hair follicle). […] Staphylococcus aureus can be cultured from the skin lesions. […] Most people with boils are otherwise healthy and have good personal hygiene. They do however carry Staphylococcus aureus on the surface of their skin (staphylococcal carrier state). […] Tiny nicks or grazes or something rubbing against the skin can innoculate the bacteria into the wall of a hair follicle which is a weak point in the skin’s defences. […] Although most people with boils are otherwise healthy, boils are sometimes related to immune deficiency, anaemia, diabetes, smoking or iron deficiency.
- #26 Boilshttps://www.nhs.uk/conditions/boils/
A boil is a hard and painful lump that fills with pus. […] You may be more likely to get boils if you have a long-term condition that affects your immune system, such as diabetes or HIV. […] You may also be more likely to get boils if: you’re a man, you’ve been in close contact with someone with boils, you have certain skin conditions, such as eczema, you take certain medicines, such as steroids, you’re living with obesity or malnutrition. […] Carbuncles are less common and mostly affect middle-aged men.
- #27 Information on Skin Boils, Carbuncles & Abscesses – Causes of Skin Boilshttps://www.nativeremedies.com/ailment/skin-boils-and-carbuncles-info
Bacterial infections, or the inflammation of one or more hair follicles, can result in the formation of a boil. […] The main cause of skin boils is generally due to an infection of a hair follicle. This can occur for a number of different reasons. […] While anyone can develop boils and carbuncles, people who have diabetes, a suppressed immune system, poor hygiene, acne, or other skin problems are at a higher risk. […] Contributing Causes of Boils include chafing clothes, malnutrition (Vitamin A or E deficiency in particular), blocked sweat glands that become infected, and poor hygiene.
- #28 Boil – Wikipediahttps://en.wikipedia.org/wiki/Boil
A boil, also called a furuncle, is a deep folliculitis, which is an infection of the hair follicle. It is most commonly caused by infection by the bacterium Staphylococcus aureus, resulting in a painful swollen area on the skin caused by an accumulation of pus and dead tissue. […] Most human infections are caused by coagulase-positive S. aureus strains, notable for the bacteria’s ability to produce coagulase, an enzyme that can clot blood. […] Naturally the cause is bacteria such as staphylococci that are present on the skin. Bacterial colonisation begins in the hair follicles and can cause local cellulitis and inflammation. […] Risk factors for furunculosis include bacterial carriage in the nostrils, diabetes mellitus, obesity, lymphoproliferative neoplasms, malnutrition, and use of immunosuppressive drugs.
- #29 What Is a Carbuncle?https://www.lohiderm.com/blog/447355-what-is-a-carbuncle
A boil is an infection of the hair follicle that develops under the skin. When multiple boils develop this is known as a carbuncle. […] Most of the time, bacteria known as staphylococcus aureus are to blame for carbuncles. This bacteria is already present on the skin, but can easily get into a hair follicle through a cut or opening. […] Since a carbuncle is the result of a bacterial infection, the infection can be spread to others by sharing items such as towels or through skin-to-skin contact.
- #30 What Is a Carbuncle?https://www.drpwderm.com/blog/447374-what-is-a-carbuncle/
A boil is an infection of the hair follicle that develops under the skin. When multiple boils develop this is known as a carbuncle. […] Most of the time, bacteria known as staphylococcus aureus are to blame for carbuncles. This bacteria is already present on the skin, but can easily get into a hair follicle through a cut or opening. […] There are many risk factors that can cause someone to be prone to carbuncles. These risk factors include: Chronic skin problems, Older age, Obesity, Poor hygiene, Liver disease, Diabetes, A weakened immune system. […] Of course, people donât have to have these risk factors to develop this skin infection. Many health individuals deal with this issue too. For example, those in community settings such as a dorm room may be more at risk for spreading this infection.
- #31 Folliculitis, Boils and Carbuncles | Loma Linda University Healthhttps://lluh.org/conditions/folliculitis-boils-and-carbuncles
Folliculitis, boils, and carbuncles are types of infections of one or more hair follicles. […] Bacteria called Staphylococcus aureus (staph) are the most common cause of these infections. […] The infections can occur anywhere on the skin where there is hair. They happen most often where there may be rubbing and sweating. […] Symptoms may include redness, pus, pain, and fluid leaking from the sore. […] Folliculitis and mild boils may go away with no treatment or with topical treatments applied to your skin. Moderate to severe boils and carbuncles are often treated by draining. You may also need to take antibiotic medicine by mouth (oral) or by IV in a vein.
- #32 Carbuncle: Causes, Symptoms & Best Treatment Optionshttps://www.bajajallianz.com/blog/wellness/carbuncle-causes-symptoms-and-treatment.html
Friction and sweating: Areas of the body that experience friction and excess sweat are more prone to developing infections. […] Chronic skin conditions: Those with skin conditions like acne or eczema are at a higher risk of developing carbuncles due to the increased number of open pores or wounds. […] Shaving or hair removal: Improper shaving techniques or hair removal can cause minor cuts, increasing the risk of bacterial infections.
- #33 Carbuncle – Symptoms, Causes, Treatmentshttps://resources.healthgrades.com/right-care/skin-hair-and-nails/carbuncle
The infection that causes carbuncles can be contagious; therefore, care should be taken to limit the spread of the infection. […] A number of factors increase the risk of developing carbuncles. Not all people with risk factors will get carbuncles. Risk factors for carbuncles include: […] Conditions that weaken the immune system, such as immunosuppressant drugs used in chemotherapy. […] Overall poor health. […] Poor hygiene.
- #34 What Is a Carbuncle? Symptoms, Treatment, and Morehttps://www.verywellhealth.com/carbuncle-information-1069430
Getting a carbuncle infection treated quickly is essential to reduce the risk of developing more severe complications, including: Brain, skin, spinal cord, or organ abscesses (pockets of infection), Inflammation of the heart, Permanent scarring, Sepsis (a body-wide reaction to an infection in the blood) and infection spread, Osteomyelitis (bone infection). […] Roughly 10% of people who develop a boil will do so again within 12 months. Some factors that drive carbuncle recurrence include: Being younger (under 30 years), Being colonized with (a carrier of) staph bacteria, Diabetes, Having obesity, Smoking, Taking antibiotics in the six months prior to its developing.
- #35 Boil: Causes, Symptoms, Treatments, and Morehttps://resources.healthgrades.com/right-care/skin-hair-and-nails/boil
Possible complications of a boil include: abscesses from large boils, carbuncles, which occur when multiple boils join together, cellulitis, which occurs when surrounding tissue becomes infected, lymphangitis, which occurs when the infection affects a lymph vessel, lymphadenitis, which occurs when lymph nodes become inflamed, furunculosis, which is when boils keep recurring or develop in multiple places, meningitis or blood clots if the bacteria from a face boil spread to the brain. […] A boil is a bacterial infection that involves hair follicles.
- #35 Boil: Causes, Symptoms, Treatments, and Morehttps://resources.healthgrades.com/right-care/skin-hair-and-nails/boil
A boil, or a furuncle, is an infection involving a hair follicle on the skin. It happens when bacteria enter the skin. Boils are typically caused by Staphylococcus aureus bacteria, though they may be due to other bacteria or fungi present on the skin surface. If multiple boils occur, this is known as a carbuncle. […] Boils form when bacteria from the skin surface infiltrate a hair follicle, infecting the hair follicle and surrounding tissue. This can happen due to friction or bacteria entering the skin through a cut or graze. […] Boils may form individually or group together. When multiple boils fuse to become one lump, the resulting lump is called a carbuncle. […] A boil occurs as a result of a bacterial infection. It is possible that this infection can spread, resulting in complications.
- #36 Boils and carbuncles – Diagnosis & treatment – Mayo Clinichttps://www.mayoclinic.org/diseases-conditions/boils-and-carbuncles/diagnosis-treatment/drc-20353776
Many varieties of the bacteria that cause boils have become resistant to certain types of antibiotics. […] Sometimes your doctor may prescribe antibiotics to help heal severe or recurrent infections.
- #37 Furunculosis | Symptoms & Treatment – Skinsighthttps://skinsight.com/skin-conditions/furunculosis-boil/
Boils (furuncles) are painful pus-filled bumps (pustules) on the skin resulting from the deep infection of a hair follicle. The infection is usually caused by a type of bacteria called Staphylococcus aureus (commonly known as staph). […] Tiny breaks in the surface of the skin (such as those caused by friction or scratching), however, can help the bacteria gain entry into and infect the hair follicle, resulting in a boil. […] People who are particularly prone to developing boils include: […] Carriers of staph. […] The pus inside of a boil needs to be drained thoroughly before the body can completely clear the infection. […] Your medical professional may collect a swab of the pus for laboratory analysis and swabs from other areas of the body (eg, nose, armpits, and/or anus and genital area) to determine if you are a carrier of staph.
- #38 Boil – Wikipediahttps://en.wikipedia.org/wiki/Boil
People with recurrent boils are as well more likely to have a positive family history, take antibiotics, and to have been hospitalised, anemic, or diabetic; they are also more likely to have associated skin diseases and multiple lesions. […] Other causes include poor immune system function such as from HIV/AIDS, diabetes, malnutrition, or alcoholism. […] Poor hygiene and obesity have also been linked. […] An associated skin disease favors recurrence. This may be attributed to the persistent colonization of abnormal skin with S. aureus strains, such as is the case in persons with atopic dermatitis. […] Boils which recur under the arm, breast or in the groin area may be associated with hidradenitis suppurativa (HS).