Materiały źródłowe

• #1 Prevention of the First Episode of Psychosis

  https://pmc.ncbi.nlm.nih.gov/articles/PMC3073532/

  Long a desired goal, but increasingly a focus of research on clinical practice, prevention of psychosis has emerged as one of the most promising and impactful areas of investigational interest and effort in psychiatry. […] Current research is focused on improving the accuracy of prediction based on clinical and neurocognitive measures and on refining treatments for the earliest symptoms of the psychoses. […] The most significant empirical influence on the emergence of deliberate efforts to prevent psychotic disorders has been the evidence that the duration of untreated first episode of psychosis has some of the most enduring impacts on the course of illness of any known later treatment. […] The current approach asserts that those processes can be altered and even reversed by earlier treatment.

• #2 Prevention of Psychosis in the Symptomatic Prodromal Phase

  https://www.medscape.com/viewarticle/844620

  Evidence has been accumulating that it may be possible to achieve prevention in psychotic disorders. The aim of the Prevention Of Psychosis (POP) study is to reduce the annual incidence of psychotic disorders in a catchment area population through detection and intervention in the prodromal phase of disorder. […] If we can identify people about to become psychotic with high accuracy, we can track them to understand more about how psychosis unfolds. Appropriate intervention at this stage could also prevent or delay the onset of psychosis and/or subsequent deterioration, i.e., social and instrumental disability, suicide, aggressive behavior, affective- and cognitive deficits.

• #3 Primary prevention of psychosis through interventions in the symptomatic prodromal phase, a pragmatic Norwegian Ultra High Risk study | BMC Psychiatry | Full Text

  https://bmcpsychiatry.biomedcentral.com/articles/10.1186/s12888-015-0470-5

  Evidence has been accumulating that it may be possible to achieve prevention in psychotic disorders. The aim of the Prevention Of Psychosis (POP) study is to reduce the annual incidence of psychotic disorders in a catchment area population through detection and intervention in the prodromal phase of disorder. […] Positive results could potentially revolutionize therapy by treating risk earlier rather than disorder later and could open a new era of early detection and intervention in psychosis. […] Appropriate intervention at this stage could also prevent or delay the onset of psychosis and/or subsequent deterioration, i.e., social and instrumental disability, suicide, aggressive behavior, affective- and cognitive deficits. […] Given these empirical data it is timely to test whether very early intervention can actually prevent the development of disorder in individuals at high risk (i.e. primary prevention).

• #4 Early intervention in psychosis – Wikipedia

  https://en.wikipedia.org/wiki/Early_intervention_in_psychosis

  Early intervention in psychosis is a clinical approach to those experiencing symptoms of psychosis for the first time. It forms part of a new prevention paradigm for psychiatry and is leading to reform of mental health services, especially in the United Kingdom and Australia. […] The aim is to reduce the usual delays to treatment for those in their first episode of psychosis. The provision of optimal treatments in these early years is thought to prevent relapses and reduce the long-term impact of the condition. It is considered a secondary prevention strategy. […] Interventions to prevent a further episodes of psychosis (a „relapse”) and strategies that encourage a return to normal vocation and social activity are a priority. […] Prodrome or at risk mental state clinics are specialist services for those with subclinical symptoms of psychosis or other indicators of risk of transition to psychosis.

• #5 Early Psychosis and the Prevention and Mitigation of Serious Mental Illness | SpringerLink

  https://link.springer.com/chapter/10.1007/978-3-031-10239-4_43

  Treatment of adults with serious mental illness is hampered by the difficulty of trying to undo the ravages that years of mental illness cause. […] This chapter will describe the scientific foundations of early treatment for psychosis including a description of the evidence indicating that longer duration of untreated psychosis is a strong predictor of worse short-term and long-term outcomes. […] The chapter will also cover the evidence supporting the effectiveness of specialized early treatment focused on recovery as well as the scientific and policy factors that led to the unusually rapid dissemination of FEP treatment throughout the country.

• #6 Preventing psychosis in people at clinical high risk: an updated meta-analysis by the World Psychiatric Association Preventive Psychiatry section | Molecular Psychiatry

  https://www.nature.com/articles/s41380-025-02902-8

  Recently published large-scale randomised controlled trials (RCTs) have questioned the efficacy of preventive interventions in individuals at clinical high risk for psychosis (CHR-P). […] Results showed no evidence that any of the investigated active interventions had a sustained and robust effect on any of the investigated outcomes in CHR-P, when compared to control interventions, including CBT on transition to psychosis at 12 months. […] These results highlight the need for novel treatment approaches in CHR-P. Future studies should consider the heterogeneity of this clinical population and prioritise stratification strategies and bespoke treatments. […] The clinical high risk for psychosis (CHR-P) paradigm, based on subclinical symptoms of psychosis, is one of the most established preventive approaches in psychiatry.

• #7 Early Intervention & Prevention -The Psychosis Research Unit

  https://psychosisresearch.com/early-intervention-prevention/

  Early Intervention Prevention Psychotic disorders, such as schizophrenia, affect approximately 1 in 100 people, and can be severely disabling. […] Studies have demonstrated the possibility of finding people who are at high risk of developing psychosis (leading to diagnoses such as schizophrenia), which opens up the prospect of preventing psychosis. There is also evidence that early intervention for psychosis can reduce burden and disability and is associated with better social and clinical outcomes. […] Tony Morrison and Paul French conducted the worlds first clinical trial using only a psychological intervention (CBT, which should have less severe side effects than antipsychotic medication), which found a sample of people at high-risk, who are distressed and help-seeking because of incipient or attenuated symptoms, and demonstrated that cognitive therapy seems to prevent or delay the development of psychosis, in comparison with regular monitoring (Morrison et al, 2004).

• #8 Prevention of the First Episode of Psychosis

  https://pmc.ncbi.nlm.nih.gov/articles/PMC3073532/

  The prodromal period, on the other hand, can last for months to years, making its identification a feasible means of achieving the goal of indicated prevention. […] Thus, at present, prevention of schizophrenia and other psychotic disorders constitutes secondary prevention, or in current terminology, indicated prevention. […] Given the long prodromal period (often up to a year) within which it is possible to identify individuals at risk, early identification and intervention have made possible a substantial improvement in functioning, symptomatology and prognosis. […] The evidence for the long-term negative impact of untreated psychosis has led to early treatment being increasingly considered as the necessary step to preventing deterioration and resistance to treatment. […] Recent clinical research has shown that very early application of existing and only slightly modified evidence-based treatments for schizophrenia and mood disorders can markedly improve outcome and prognosis.

• #9 Establishing a clinical service to prevent psychosis: What, how and when? Systematic review | Translational Psychiatry

  https://www.nature.com/articles/s41398-020-01165-x

  The first rate-limiting step to successfully translate prevention of psychosis in to clinical practice is to establish specialised Clinical High Risk for Psychosis (CHR-P) services. […] A recent evidence-based summary by the European College of Neuropsychopharmacology Network for the Prevention of Mental Disorders and Mental Health Promotion indicated that the first rate-limiting step to prevent psychosis is to establish specialised CHR-P services. […] While previous systematic reviews have addressed these issues for services taking care of patients with a first episode of psychosis, CHR-P research has remained mostly academic and did not systematically address real-world service characteristics such as: service configuration, outreach strategy and referrals, service user characteristics, interventions, and outcomes.

• #10 Prevention of the First Episode of Psychosis

  https://pmc.ncbi.nlm.nih.gov/articles/PMC3073532/

  The PIER program was developed in 2000, to undertake systematic early detection, intervention and prevention of psychosis throughout an entire urban area, by providing treatment during the prodromal period. […] Systems of early detection, intervention and secondary or indicated prevention have been developed and tested in the UK, Australia, Scandinavia, Germany, Austria and North America. […] The results also confirm that early detection is feasible. […] The efficacy of low-intensity/low-risk family psychoeducational intervention and O-3 FAs illustrate this point. […] The public health implications of that eventual outcome cannot be underestimated.

• #11 Interventions to Prevent Psychosis – The New York Times

  https://www.nytimes.com/2019/09/02/well/mind/interventions-to-prevent-psychosis.html

  Tiffany Martinez was a 17-year-old college freshman when she began hearing voices, seeing shadowy figures and experiencing troubling, intrusive thoughts. […] They most likely saved her from a crippling mental health crisis, prevented the derailment of her education and ultimately enabled her to become a psychiatric nurse practitioner who can help other young people avert a psychiatric crisis. […] The nurse suspected that Tiffany was at risk of developing a psychotic episode and referred her to the Portland Identification and Early Referral, or PIER, program at the Maine Health Center. […] The program was developed in 2001 by Dr. William R. McFarlane, a psychiatrist who suspected that if early intervention could reverse the course of diseases like cancer and heart disease, it should do likewise for psychosis.

• #12 Early Psychosis Prevention & Intervention Service (EPPIS) – Shared Health

  https://sharedhealthmb.ca/services/mental-health/mha-services/eppis/

  One of the most important ways to improve outcomes in psychosis is to initiate treatment early. Research indicates that individuals receiving optimal treatment within 6 months of onset of symptoms have a better recovery than those who delay treatment. For this reason EPPIS does not have a wait list and attempts to see individuals quickly after referral has been received so treatment can be optimized early in the course. […] Current treatments can be very effective and many individuals recover from a first episode of psychosis. The earlier the disorder is treated, the greater the chance of a successful recovery. Other benefits to early intervention for psychosis include reduced symptoms and distress, preservation of psychosocial skills, preservation of family and social supports, decreased need for hospitalization, more rapid recovery and over all improved prognosis.

• #13

  http://mchp-appserv.cpe.umanitoba.ca/supp.php/mchp/eppis.html

  EPPIS provides psychiatric service and support to individuals between 13-35 years of age who are experiencing or recovering from a first episode of psychosis. […] Early psychosis may be indicated by prodromal symptoms (i.e., symptoms that present a change from previous status), such as depression or anxiety, sleep disruption, declining functioning at school or work, or social withdrawal. […] Previous research indicates that individuals receiving optimal treatment within 6 months of onset of symptoms have a better recovery than those who delay treatment (1-3). […] The program stresses the importance of early integration with family and community, restoring the individuals prior personal roles and responsibilities, and the development of suitable life goals. […] Success in the program should reduce demand for intensive health services, and improve social functioning and education outcomes.

• #14 Prevention of psychosis: moving on from the at-risk mental state to universal primary prevention

  https://pmc.ncbi.nlm.nih.gov/articles/PMC7893507/

  The value of services for those with the At Risk Mental State for Psychosis (ARMS) continues to be disputed. […] We consider that the most productive approach for psychosis prevention is avoiding exposure to risk-increasing factors. The best-established risk factors for psychosis are obstetric events, childhood abuse, migration, city living, adverse life events and cannabis use. […] Therefore, as an initial step towards a strategy for universal primary prevention, we advocate public health campaigns to educate young people about the harms of regular use of high potency cannabis. […] We conclude that ARMS Clinics are never likely to make major inroads into preventing the majority of people who develop psychosis. An approach which could have a greater effect is to focus on avoiding the risk factors which increase the risk of the illness. […] Therefore, as an initial step towards universal primary prevention, we suggest major campaigns to educate young people about the harms of regular use of high potency cannabis.

• #15 Prevention of psychosis: moving on from the at-risk mental state to universal primary prevention | Psychological Medicine | Cambridge Core

  https://www.cambridge.org/core/journals/psychological-medicine/article/prevention-of-psychosis-moving-on-from-the-atrisk-mental-state-to-universal-primary-prevention/D1BF4068B459A19D9EF2EBF67098B540

  The value of services for those with the At Risk Mental State for Psychosis (ARMS) continues to be disputed. […] We consider that the most productive approach for psychosis prevention is avoiding exposure to risk-increasing factors. The best-established risk factors for psychosis are obstetric events, childhood abuse, migration, city living, adverse life events and cannabis use. […] Therefore, as an initial step towards a strategy for universal primary prevention, we advocate public health campaigns to educate young people about the harms of regular use of high potency cannabis. […] We argue that a better approach would be public health interventions with the primary focus on reducing exposure to the risk factors. […] A number of authors have raised the possibility of applying the principles of primary prevention to psychiatry in general

• #16 Prevention of psychosis: moving on from the at-risk mental state to universal primary prevention | Psychological Medicine | Cambridge Core

  https://www.cambridge.org/core/journals/psychological-medicine/article/prevention-of-psychosis-moving-on-from-the-atrisk-mental-state-to-universal-primary-prevention/D1BF4068B459A19D9EF2EBF67098B540

  but only a few studies have focussed on psychosis. […] We conclude that ARMS Clinics are never likely to make major inroads into preventing the majority of people who develop psychosis. An approach which could have a greater effect is to focus on avoiding the risk factors which increase the risk of the illness. […] Therefore, as an initial step towards universal primary prevention, we suggest major campaigns to educate young people about the harms of regular use of high potency cannabis.

• #17 Reimagining psychosis prevention: responding to the accessibility issues of At-Risk Mental State (ARMS) services through a selective public health approach | BJPsych Bulletin | Cambridge Core

  https://www.cambridge.org/core/journals/bjpsych-bulletin/article/reimagining-psychosis-prevention-responding-to-the-accessibility-issues-of-atrisk-mental-state-arms-services-through-a-selective-public-health-approach/A8E99961DA20C405A364BAE1AF86E2DC

  Collectively, these points raise questions about the accessibility and sensitivity of the ARMS preventative model, which is further concerning given the National Health Service’s (NHS) commitment to preventative healthcare and reducing health inequalities. […] Although there is greater recognition of the need for complementary approaches to ARMS services, rare is there a discussion about how this can be achieved. […] Selective and universal public health preventative approaches have the potential to overcome the limitations of the ARMS model, as preventative care is directly targeted at the general population, in what is referred to as upstream working. […] One of the overarching mechanisms by which selective or universal prevention could act to stop psychosis transition is by addressing the social factors that predispose healthy individuals to psychosis, known as social determinants.

• #18 Early Intervention & Prevention -The Psychosis Research Unit

  https://psychosisresearch.com/early-intervention-prevention/

  Six RCTs, including these two, were reviewed by NICE, who concluded that psychosis is preventable, which has enormous implications because of the considerable personal, economic and social costs of this disorder (Stafford et al, BMJ, 2013). […] The NICE Guidelines For Young People CG155 and Adults CG178 now recommend that people at risk of developing psychosis are offered CBT. […] There is considerable evidence that early intervention for psychosis is associated with better outcomes for people. […] The NICE guidelines for young people (CG155) and adults (CG178) with psychosis now recommend that all people experiencing a first episode of psychosis should have rapid access to such early intervention services.

• #19 Psychosis – Wikipedia

  https://en.wikipedia.org/wiki/Psychosis

  The evidence for the effectiveness of early interventions to prevent psychosis appeared inconclusive. […] But psychosis caused by drugs can be prevented. […] Whilst early intervention in those with a psychotic episode might improve short-term outcomes, little benefit was seen from these measures after five years. […] However, there is evidence that cognitive behavioral therapy (CBT) may reduce the risk of becoming psychotic in those at high risk, and in 2014 the UK National Institute for Health and Care Excellence (NICE) recommended preventive CBT for people at risk of psychosis.

• #20 Hope for Young People at Risk of Developing Psychosis | Mount Sinai Today

  https://health.mountsinai.org/blog/treating-young-people-at-risk-of-developing-psychosis/

  This type of CBT is adapted for people with clinical high risk, and research has shown that it can delay the progression to psychosis for at least four years, says clinical psychologist Yulia Landa, PsyD, MS, assistant professor of psychiatry, Director of Cognitive Behavioral Therapy for the Treatment and Prevention of Psychosis research and clinical program, and co-director of the Psychosis Risk Program. “We will need much longer longitudinal studies to know if CBT can really prevent psychosis, but we can delay it, and maybe prevent it,” she says. […] “Eventually we want to establish solid interventions that could be disseminated across Mount Sinai and integrated into community practice,” Dr. Landa says. […] “We’ve identified a number of biomarkers that are predictive of psychosis,” Dr. Corcoran says. “We want to understand how they relate to each other, to better understand the causes of psychosis and ultimately to develop new pharmacological treatments.”

• #21 First Episode of Psychosis Treatment Programs | Louisiana Department of Health

  https://www.ldh.la.gov/office-of-behavioral-health/first-episode-of-psychosis-treatment-programs

  First episode psychosis (FEP) can be described as a disruption to a persons thoughts and perceptions that may make it difficult for them to understand what is real and what is not. Research has shown that people experiencing psychosis have better treatment outcomes when they receive care as early as possible following their first experience with these symptoms. […] Coordinated specialty care (CSC) is designed to meet the needs of those experiencing FEP. The CSC model incorporates a comprehensive package of services, including medication/primary care, psychotherapy, case management, family education and support, and supported employment and education. […] NAVIGATE, a comprehensive program implementing CSC for effective treatment of individuals experiencing early psychosis.

• #22 Early Intervention Treatments for Psychosis

  https://www.thenationalcouncil.org/program/early-intervention-treatments-for-psychosis/

  The National Council for Mental Wellbeing is launching the Mental Health First Aid First Episode Psychosis Community of Practice to facilitate earlier interventions and improve outcomes for First Episode Psychosis (FEP). […] The lack of early treatment interventions available for persons that experience psychosis often leads to individuals living with a lifetime of disability. Through the promise of early intervention for psychosis treatments, individuals with psychosis are much more able to live healthy and productive lives at school, at work, and at home. […] The research produced by the National Institute for Mental Health demonstrated that coordinated specialty care treatments and supports can help prevent the full-onset of illness for high-risk persons and improve the long-term outcomes for individuals who have already experienced a first episode of psychosis.

• #23 Massachusetts Strategic Plan for Prevention: Early Detection and Intervention of Psychosis – Bouvé College of Health Sciences

  https://bouve.northeastern.edu/institute-for-health-equity-and-social-justice-research/projects/massachusetts-strategic-plan-for-psychosis-prevention/

  The Massachusetts Department of Mental Health is committed to increasing the accessibility and availability of effective information, supports, and services that take into account and respect the diverse cultural and linguistic needs of Massachusetts’ youth and young adults who are at risk for psychosis or who are experiencing the recent onset of psychosis and their families and friends. […] SAMHSA recently articulated goals for states’ efforts: delay or prevent the onset of psychosis; and minimize the duration of untreated psychosis for those who develop psychotic symptoms. […] The RAISE studies have been heralded as evidence that there is effective treatment for youth experiencing first episode psychosis and their families and these treatments can be delivered in ‘real world’ settings relying largely on third party payments.

• #24 Preventing psychosis in people at clinical high risk: an updated meta-analysis by the World Psychiatric Association Preventive Psychiatry section | Molecular Psychiatry

  https://www.nature.com/articles/s41380-025-02902-8

  A recent meta-umbrella systematic review showed that effective interventions in CHR-P could prevent up to 12.4% of all cases of psychosis. […] However, a network meta-analysis found a lack of evidence to favour any active intervention for prevention of psychosis needs-based care. […] Our main finding was that CBT was not more effective than the control interventions in preventing transition to FEP in CHR-P at both 6 and 12 months. […] Our quantitative summary on Omega-3 fatty acids, antipsychotics, and CBT plus antipsychotics confirmed previous evidence on lack of efficacy of these interventions in preventing psychosis in CHR-P at any of the investigated time points. […] The most promising results on reducing risk of psychosis transition in CHR-P were reported by the only trial investigating an integrated psychological approach, combining CBT, cognitive remediation, and psychoeducation. […] Our findings indicate the need for a new generation of preventive interventions for psychosis in CHR-P.

• #25 Psychosis Risk Program | Mount Sinai – New York

  https://www.mountsinai.org/care/psychiatry/services/schizophrenia/psychosis-risk

  At Mount Sinai’s Psychosis Risk Program, we work with teenagers and young adults who are experiencing changes in their mood and behavior. […] Patients in our program may receive individual, group, or family therapy, or some combination of modalities, based on their treatment goals and needs. […] We offer the following services: […] Cognitive Behavioral Therapy: Prevention of Symptoms and Psychosis through Education and Cognitive Therapy (ProSPECT) is a service for young people at risk between the ages 12-25 and their families. ProSPECT provides specialized evaluations, cognitive behavioral therapy (CBT), support with work and school goals through a mentorship program, and connection to auxiliary services as needed. […] The group and family-based cognitive behavioral therapy (GF-CBT) is an evidence-based treatment that aims to facilitate psychosocial recovery, decrease symptoms, and prevent psychosis in youth at risk. GF-CBT helps young people and their families to develop a better understanding of their psychotic-like experiences and sharpen their reasoning skills to prevent the formation of stressful paranoid thoughts.

• #26 Prevention and Recovery from Early Psychosis

  https://www.voaut.org/get-help/mental-health-services/prevention-and-recovery-from-early-psychosis

  PREP provides services including case management, psychiatric medication, psychotherapy, family education and support, and vocational support. Individuals between the ages of 16 to 26 who have been deemed clinically high-risk or are already experiencing initial symptoms of psychosis are eligible regardless of insurance or funding. Therapists on the PREP team are training to utilize cognitive behavioral therapy (CBT) as an effective intervention for symptoms of psychosis. Family psycho-education so that consumers choose the support people they want involved in their recovery, and families/supports get information that helps them play an active role in the recovery process. […] Our specialty care treatment model provides support services for individuals who are determined to be high-risk for, or have already experienced their first episode of psychosis.

• #27 Treatment – Psychosis – NHS

  https://www.nhs.uk/mental-health/conditions/psychosis/treatment/

  Treatment for psychosis involves a combination of antipsychotic medicines, talking therapies and social support. […] An early intervention team is a team of healthcare professionals set up specifically to work with people who have experienced their first episode of psychosis. […] Treatment for psychosis will vary, depending on the underlying cause. […] Antipsychotic medicines are usually recommended as the first treatment for psychosis. […] Antipsychotics can usually reduce feelings of anxiety within a few hours of use, but they may take several days or weeks to reduce psychotic symptoms, such as hallucinations or delusional thoughts. […] Talking therapies can help reduce the intensity and anxiety caused by psychosis. […] Family intervention is known to be an effective form of therapy for people with psychosis.

• #28 Postpartum Psychosis Can be Prevented in Women at High Risk – MGH Center for Women’s Mental Health

  https://womensmentalhealth.org/posts/postpartum-psychosis-can-be-prevented-in-women-at-high-risk/

  It is well-established that women with a history of bipolar disorder or postpartum psychosis are at extremely high risk of postpartum psychiatric illness. Several studies have indicated that lithium prophylaxis can dramatically reduce the risk of postpartum relapse; however, the studies have varied in terms of the timing of prophylaxis, with some initiating treatment during pregnancy and others initiating treatment immediately after delivery. […] Based on these findings the authors recommend initiating prophylactic treatment with lithium immediately after delivery in women with a history of psychosis limited to the postpartum period. This approach minimizes exposure to medication during pregnancy but at the same time effectively decreases the risk of postpartum relapse. […] Furthermore, relapse during pregnancy significantly increases the risk of postpartum illness. Prophylaxis during pregnancy not only helped to maintain mood stability during pregnancy but also reduced the risk of postpartum illness. […] This study, and several others, have clearly demonstrated that we can use lithium prophylaxis to actually prevent postpartum illness in a women at high risk for postpartum psychiatric illness.

• #29 EPPIC (Early Psychosis Prevention & Intervention Centre) | Orygen Specialist Program

  https://oyh.org.au/our-services/clinical-program/continuing-care-teams/eppic-early-psychosis-prevention-intervention

  The Early Psychosis Prevention and Intervention Centre (EPPIC) works with young people with psychotic disorders. EPPIC aims to facilitate the early identification and treatment of psychosis and therefore reduce the disruption to the young persons functioning and psychosocial development. […] Without specialised services like EPPIC, there can be a long delay before a young person manages to access appropriate treatment and during this time problems can intensify. These delays can be very damaging to a young person experiencing a psychotic illness because their maturation is often put on hold, their social and family relationships are strained or severed and their vocational prospects are derailed. […] Treatment Goals include early identification and treatment of the primary symptoms of psychotic illness, improve access and reduce delays in initial treatment, educate the young person and family about the illness, reduce the frequency and severity of relapse, reduce the risk of other health-related problems developing, reduce disruption to social and vocational functioning, promote wellbeing among family members and carers, support the young person during their recovery, and develop a plan for maintaining mental health.

• #30 ServiceNet | Prevention & Recovery in Early Psychosis | Western Massachusetts

  https://www.servicenet.org/services/mental-health-recovery-services/prevention-and-recovery-in-early-psychosis-prep/

  Young people who have experienced their first psychotic episode can benefit from an intensive, multifaceted program through which they learn the skills they need to move on. […] ServiceNets Prevention and Recovery in Early Psychosis (PREP) Program offers comprehensive outpatient treatment for young adults between the ages of 16 to 30 years old who have had an experience of psychosis within the previous three years. […] PREP offers comprehensive outpatient treatment for individuals age 16-30, and their families, including: […] Psychiatric Services works with participants who may be prescribed medication to help calm uncomfortable experiences. […] PREP is fully funded by the Massachusetts Department of Mental Health through a Substance Abuse and Mental Health Services Administration (SAMHSA) grant.

• #31 ServiceNet | Child & Adolescent Services | PREP | Western Massachusetts

  https://www.servicenet.org/services/child-and-adolescent-services/prevention-recovery-early-psychosis-prep-2/

  Young people who have experienced their first psychotic episode can benefit from an intensive, multifaceted program through which they learn the skills they need to move forward. […] ServiceNets Prevention and Recovery in Early Psychosis (PREP) Program offers comprehensive outpatient treatment for young adults between the ages of 16 to 30 years old who have had an experience of psychosis within the previous three years. […] PREP offers comprehensive outpatient treatment for individuals age 16-30, and their families, including: […] Psychiatric Services works with participants who may be prescribed medication to help calm uncomfortable experiences. […] Family and Network Meetings are held with the PREP team, participant, and his or her family to discuss difficult topics and discover new ways of moving forward.

• #32 Felton Institute’s PREP (Prevention and Recovery in Early Psychosis) Program Wins National Council for Behavioral Health Inspiring Hope, Science to Service Award – Felton Institute

  https://felton.org/2014/05/felton-institutes-prep-prevention-and-recovery-in-early-psychosis-program-wins-national-council-for-behavioral-health-inspiring-hope-science-to-service-award/

  The PREP program is an evidence-based, data-driven approach to schizophrenia treatment that is transforming the lives of young people in Northern California. […] Preliminary results indicate that the PREP approach can make recovery a sustainable reality for most individuals with schizophrenia when intervention occurs early, representing a dramatic change in the lives of individuals with early psychosis. […] PREP delivers comprehensive treatment grounded in wellness, recovery, and resilience to people experiencing symptoms of psychosis, as well as their families. Our vision is to transform the treatment and perception of psychosis – and by extension the lives of young people and their families – by intervening early with evidence-based, culturally competent assessment and diagnosis so that within five years of entering treatment most cases of psychosis are treated to remission.

• #33 Postpartum Psychosis: Symptoms, Treatment and PreventionCircleBumpCheckedFilledMedicalBookmarkBookmarkTickBookmarkAddCheckBoxCheckBoxFilled

  https://www.thebump.com/a/postpartum-psychosis

  Postpartum psychosis is a rare and severe condition that can occur during the postpartum period. […] Postpartum psychosis usually shows up within the first two weeks of childbirth, but may occur anytime within the first year. […] Postpartum psychosis is often seen in new moms, but may also occur in women who’ve experienced a stillbirth or infant loss. […] While there’s no way to completely prevent postpartum psychosis, there are steps you can take to manage certain risks, says Chaffin. […] It’s imperative for loved ones to seek help immediately if they spot any postpartum psychosis symptoms or warning signs.

• #34 The Promotion of Mental Health and Prevention of First-Episode Psychosis: A Pilot and Feasibility Non-Randomised Clinical Trial

  https://www.mdpi.com/1660-4601/20/22/7087

  Adolescence is a concept that is difficult to categorise and comprises a transition period from infancy to adulthood, in which there are important changes at a physical, cognitive, and emotional level, making it a phase filled with energy and opportunities, but also with risks and vulnerabilities. […] Given that psychosis, or First-Episode Psychosis (FEP) if it occurs for the first time, usually debuts from age 15 and its onset is progressive and insidious, where there is an alteration of reality, it would be interesting to perform a psychoeducational programme based on the Vulnerability-Stress model to increase knowledge on mental health and FEP on teachers and counsellors of a secondary school in order to reduce the associated stigma. […] The intervention was structured from August to December 2021 and was implemented at the end of February 2022. […] The outcomes showed that the intervention was useful for increasing knowledge on mental health and reducing the stigma associated with this type of population, given the statistically significant differences found in the average scores of the AQ-27 variables pre- and post-intervention.

• #35 Prevention of the first episode of psychosis.

  https://knowledgeconnection.mainehealth.org/mmc/1293/

  Long a desired goal but increasingly a focus of research on clinical practice, prevention of psychosis has emerged as one of the most promising and effective areas of investigational interest and effort in psychiatry. […] current research is focused on improving the accuracy of prediction based on clinical and neurocognitive measures and on refining treatments of the earliest symptoms of the psychoses. […] Both efforts are bearing success, although there remains ambiguity as to the most effective preventive interventions.

• #36 National conference on psychosis prevention

  https://maudsleylearning.com/courses/national-conference-on-psychosis-prevention/

  This conference is jointly organised by Maudsley Learning, Kings College London, and the Outreach and Support in South London (OASIS) team at South London and Maudsley (SLaM) NHS Foundation Trust. It will take place as part of a nationwide training programme on the use of the Comprehensive Assessment of At-Risk Mental States (CAARMS), commissioned by NHS England. […] The event will feature presentations from leading experts in psychosis risk and prevention, including clinicians, researchers, and individuals with lived experience. Attendees will also have the opportunity to participate in networking sessions, exchanging real-world insights with practitioners from clinical services across England. […] The conference will cover the following topics: Prevention of psychosis at SLaM, Prevention of psychosis at OASIS and worldwide: achievements and challenges, Neurobiological and cognitive markers of psychosis risk, Innovative preventive treatments for psychosis, Establishment and management of an NHS service for psychosis prevention, The perspective of experts with lived experience. […] Expert in early psychosis detection and intervention, with a focus on cognitive processes and novel treatments for those at risk of psychosis. […] Providing psychological therapy for people with psychosis, improving access to talking therapies for those with severe mental illness.

• #37 Focusing on Youth Psychosis Prevention through Psychology | CAMH

  https://www.camh.ca/en/camh-news-and-stories/focusing-on-youth-psychosis-prevention-through-psychology

  Focusing on Youth Psychosis Prevention through Psychology […] We however believe that prevention can make a remarkable impact in the field of psychosis. […] Unlike other psychosis services, our mandate is to intervene during the Clinical High Risk (CHR) state a period that precedes a psychotic episode. […] For example, recently-released guidelines recommend psychosocial treatments (such as Cognitive Behavioral Therapy, or CBT) as the first line of treatment in preventing psychosis during the CHR state, with medical treatments (such as antipsychotic medication) recommended only when psychosocial treatment is ineffective. […] Furthermore, neuropsychological assessment the use of mental ability testing to make inferences about brain function has also shown promise in predicting who is most likely to develop psychosis.

• #38 Focusing on Youth Psychosis Prevention through Psychology | CAMH

  https://www.camh.ca/en/camh-news-and-stories/focusing-on-youth-psychosis-prevention-through-psychology

  Through research, we hope to both improve the accuracy of early prediction of psychotic episodes and to improve our ability to intervene with novel psychosocial treatments. […] The psychology team plays an integral part, providing outreach talks in schools, youth shelters, and other places where youth congregate. […] Dr. Thomas Insel, director of the National Institutes of Mental Health in the US, wrote of this new approach to psychosis intervention, stating now that we have the tools available for predicting risk, we can get serious about preventing psychosis and enabling these young people to engage in, rather than withdraw from life. […] Were serious about preventing psychosis, and I am proud to be a member of the psychology discipline, helping fulfill this goal.

• #39 Reimagining psychosis prevention: responding to the accessibility issues of At-Risk Mental State (ARMS) services through a selective public health approach | BJPsych Bulletin | Cambridge Core

  https://www.cambridge.org/core/journals/bjpsych-bulletin/article/reimagining-psychosis-prevention-responding-to-the-accessibility-issues-of-atrisk-mental-state-arms-services-through-a-selective-public-health-approach/A8E99961DA20C405A364BAE1AF86E2DC

  A placed-based health partnership will be most effective in delivering these interventions. […] In conclusion, the accessibility of existing preventative strategies for psychosis requires us to explore greater diversity in our approach. […] We believe that a public health approach employing a selective preventative strategy offers a novel and equitable way to achieve this, by focusing on communities at increased risk in the general population and developing collaboration between the healthcare system and different social organisations.

• #40 Reimagining psychosis prevention: responding to the accessibility issues of At-Risk Mental State (ARMS) services through a selective public health approach | BJPsych Bulletin | Cambridge Core

  https://www.cambridge.org/core/journals/bjpsych-bulletin/article/reimagining-psychosis-prevention-responding-to-the-accessibility-issues-of-atrisk-mental-state-arms-services-through-a-selective-public-health-approach/A8E99961DA20C405A364BAE1AF86E2DC

  At-Risk Mental State (ARMS) services aim to prevent the onset of first-episode psychosis (FEP) in those with specific clinical or genetic risk markers. […] In England, ARMS services are currently expanding, but the accessibility of this preventative approach remains questionable, especially for a subgroup of FEP patients and those from specific ethnic minority communities. […] This commentary outlines the key debates about why a complimentary approach to psychosis prevention is necessary, and gives details for an innovative public health strategy, drawing on existing research and health prevention theory. […] There are two main reasons why ARMS services are criticised for being the sole approach to prevent psychosis. […] The second critique of ARMS services is their constrained appeal.

• #41 Reimagining psychosis prevention: responding to the accessibility issues of At-Risk Mental State (ARMS) services through a selective public health approach | BJPsych Bulletin | Cambridge Core

  https://www.cambridge.org/core/journals/bjpsych-bulletin/article/reimagining-psychosis-prevention-responding-to-the-accessibility-issues-of-atrisk-mental-state-arms-services-through-a-selective-public-health-approach/A8E99961DA20C405A364BAE1AF86E2DC

  Public health interventions are effective in acting on the social determinants of psychosis. […] According to Frieden’s Six Components Model, innovation is central to the effective design and implementation of any public health programme. […] Rather than employing a universal strategy, we think there is greater utility and better use of resources by adopting a selective preventative approach. […] This public health model would aim to stop the development of new FEP cases from subpopulations at increased social risk. […] An effective preventive strategy will need to consider the mechanisms by which FEP prediction-detection technologies are used to find at-risk cases in the real world. […] Existing evidence should be used to decide which preventative interventions are adopted within the selective prevention programme.

• #42 Primary prevention of psychosis through interventions in the symptomatic prodromal phase, a pragmatic Norwegian Ultra High Risk study | BMC Psychiatry | Full Text

  https://bmcpsychiatry.biomedcentral.com/articles/10.1186/s12888-015-0470-5

  Direct but preliminary evidence for primary prevention has been generated by clinical trials in Australia, Europe and the US. If we can identify people about to become psychotic with high accuracy, we can track them to understand more about how psychosis unfolds. […] However, there are still major methodologically and practical challenges that need to be solved. The health services need to be able to identify and recruit persons who meet the current criteria which might be difficult because individuals in the high risk group don’t necessarily seek guidance actively.

• #43 Establishing a clinical service to prevent psychosis: What, how and when? Systematic review | Translational Psychiatry

  https://www.nature.com/articles/s41398-020-01165-x

  The current systematic review summarizes, for the first time, evidence on these domains to inform the real-world implementation (i.e., what, how, and when) of CHR-P clinical services worldwide. […] We provide ten practical recommendations for implementation of CHR-P services. […] The evidence summarised will then be used to operationalise ten empirical recommendations for overcoming these challenges and facilitating the real-world implementation of CHR-P services. […] Based on this evidence we recommend to preferably implement standalone services. […] We recommend a minimum team encompassing psychiatrists, clinical psychologists, or counsellors, case managers and nurses. […] In terms of outreach strategy, school, mental health, and physical health practitioners were the core targets of community outreach.

• #44 Establishing a clinical service to prevent psychosis: What, how and when? Systematic review | Translational Psychiatry

  https://www.nature.com/articles/s41398-020-01165-x

  We recommend CHR-P outreach to primarily target healthcare agencies to promote referrals from these sources. […] This review also indicated that presentation to CHR-P services was associated with frequent comorbid mental health conditions (in particular mood and anxiety disorders) in two-thirds (69.5%) of the individuals, coupled with past history of suicide attempts in about one in ten (10.5%) and unemployment in about one third (36.6%) of cases. […] In terms of interventions, most services provided care for 2 years or less, encompassing clinical monitoring (100%), psychoeducation (81.1%), psychosocial support (73%), family interventions (73%), CBT-based individual interventions (67.6%), group psychotherapy (18.9%), physical health interventions (37.8%), antipsychotics (87.1%), antidepressants (74.2%), anxiolytics (51.6%), and mood stabilisers (38.7%). […] We recommend clinical monitoring for outcomes to be implemented for at least 3 years. […] Future research is needed to standardise a core outcome set for CHR-P research and therefore facilitate collaborative efforts.

• #45 Early intervention in psychosis – Wikipedia

  https://en.wikipedia.org/wiki/Early_intervention_in_psychosis

  These services are able to reliably identify those at high risk of developing psychosis and are beginning to publish encouraging outcomes from randomised controlled trials that reduce the chances of becoming psychotic, including evidence that psychological therapy and high doses of fish oil have a role in the prevention of psychosis. […] Early intervention in psychosis is a preventive approach for psychosis that has evolved as contemporary recovery views of psychosis and schizophrenia have gained acceptance. […] The development of the EPPIC early detection service in Melbourne, Australia in 1996 and the prodrome clinic led by Alison Yung. […] There is evidence that providing access to specialized early intervention services results in benefits to patients during treatment. […] One argument in favor of creating early intervention services is that they not only improve clinical outcomes for individual patients, but also cost less than standard services to operate, for example by reducing in-patient costs.

• #46 Downloads – Early Psychosis Intervention

  https://www.earlypsychosis.ca/resources-and-downloads/

  What Can You Do About Psychosis? This section focuses on the importance of learning new skills, finding good support and taking effective medication. […] Preventing Relapse The activities in this section include identifying triggers for psychosis, recognizing early warning signs of relapse and developing a full relapse prevention plan. […] Dealing With Symptoms This section offers suggestions for different strategies for dealing with symptoms of psychosis. […] Causes of Psychosis: Speaks about the causes of psychosis and how to decrease vulnerability and stress. […] Early Intervention: A flyer regarding the benefits of early intervention and how it relates to long term treatment. […] Medication: A guide to medications used in the early treatment of psychosis. […] Relapse Prevention: How to manage if relapse occurs. […] Social Support: Social support promotes recovery. […] Stress Management Part I: Stress and how it relates to psychosis. Some strategies to deal with stress. […] Stress Management Part II: More strategies to help with stress.

• #47 Psychosis (Schizophrenia) in Children and Youth | Mental Health America

  https://mhanational.org/resources/psychosis-schizophrenia-in-children-and-youth/

  Schizophrenia and other psychotic disorders are medical illnesses that result in strange or bizarre thinking, perceptions (sight, sound), behaviors, and emotions. Psychosis is a brain-based condition that is made better or worse by environmental factors – like drug use and stress. […] Early diagnosis and medical treatment are important. It is especially important that children and youth with the problems and symptoms listed above receive a complete evaluation. These children may need individual treatment plans involving other professionals. A combination of medication and individual therapy, family therapy, and specialized programs (wraparound services, early psychosis treatment) is often necessary. Changes in life style (keeping stress low, taking fish oils), additional supports (therapy and school support) and psychiatric medication can be helpful for many of the symptoms and problems identified. […] Parents need to ask their family physician or pediatrician to refer them to a child and adolescent psychiatrist who is specifically trained and skilled at evaluating, diagnosing, and treating children with schizophrenia.

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