Otępienie z ciałami lewy’ego – Zapobieganie i profilaktyka

Otępienie z ciałami lewy’ego
Zapobieganie i profilaktyka

Otępienie z ciałami Lewy’ego (DLB) stanowi drugi co do częstości typ otępienia neurodegeneracyjnego u osób starszych, charakteryzujący się obecnością ciał Lewy’ego w mózgu. Głównym czynnikiem ryzyka jest wiek, a także nadciśnienie tętnicze, cukrzyca typu 2 i depresja. Brak skutecznego leczenia przyczynowego podkreśla znaczenie działań prewencyjnych, takich jak zaprzestanie palenia, regularna aktywność fizyczna (30-60 minut dziennie), zdrowa dieta, odpowiednia higiena snu, minimalizacja stresu oraz kontrola spożycia alkoholu. Aktywność umysłowa i społeczna, a także monitorowanie i leczenie chorób współistniejących (kontrola ciśnienia, glikemii, masy ciała, badania słuchu, leczenie depresji) są kluczowe w profilaktyce i spowalnianiu progresji DLB.

Otępienie z ciałami Lewy’ego – definicja i kontekst
Czynniki ryzyka otępienia z ciałami Lewy’ego
Strategie profilaktyczne w otępieniu z ciałami Lewy’ego

Modyfikacja stylu życia
Stymulacja poznawcza i społeczna
Kontrola chorób współistniejących

Obecne badania nad zapobieganiem otępieniu z ciałami Lewy’ego

Inhibitory cholinoesterazy
Leki stosowane w leczeniu prostaty
Badania nad układem immunologicznym

Zapobieganie upadkom u osób z otępieniem z ciałami Lewy’ego

Modyfikacje środowiska domowego

Kompleksowe podejście do profilaktyki otępienia z ciałami Lewy’ego

Kolejne rozdziały

Otępienie z ciałami Lewy’ego – definicja i kontekst

Otępienie z ciałami Lewy’ego (ang. Dementia with Lewy bodies, DLB) to drugi najczęstszy typ otępienia neurodegeneracyjnego występujący u osób starszych, charakteryzujący się obecnością okrągłych skupisk białka (ciał Lewy’ego) w mózgu¹. Jest to schorzenie, dla którego obecnie nie istnieje skuteczne leczenie przyczynowe, co powoduje, że szczególnie istotne są działania prewencyjne oraz spowalniające progresję choroby²³.

Czynniki ryzyka otępienia z ciałami Lewy’ego

Czynniki ryzyka otępienia z ciałami Lewy’ego są mniej ustalone i słabiej poznane niż w przypadku innych chorób neurodegeneracyjnych, jednak zidentyfikowano kilka potencjalnych czynników¹. Najważniejszym znanym czynnikiem ryzyka rozwoju otępienia z ciałami Lewy’ego jest wiek². Inne możliwe czynniki ryzyka obejmują nadciśnienie tętnicze, cukrzycę typu 2 oraz depresję³.

Strategie profilaktyczne w otępieniu z ciałami Lewy’ego

Chociaż nie istnieje sprawdzony sposób, który całkowicie zapobiegałby rozwojowi otępienia z ciałami Lewy’ego, dowody naukowe sugerują, że dbanie o zdrowie mózgu może zmniejszyć ryzyko rozwoju tej choroby¹². Obecnie prowadzone są intensywne badania nad nowymi lekami i strategiami terapeutycznymi³.

Modyfikacja stylu życia

Eksperci zalecają wprowadzenie następujących zmian w stylu życia, które mogą zmniejszyć ryzyko rozwoju demencji, w tym otępienia z ciałami Lewy’ego¹²:

Zaprzestanie palenia tytoniu – eliminacja nałogu palenia może znacząco wpłynąć na zmniejszenie ryzyka chorób neurodegeneracyjnych¹²
Regularna aktywność fizyczna – zalecane jest 30-60 minut ćwiczeń dziennie, co stymuluje zdolność mózgu do utrzymywania starych połączeń, tworzenia nowych i spowalniania deterioracji funkcji poznawczych²³
Stosowanie zdrowej, zbilansowanej diety – dieta ukierunkowana na zdrowie serca może pomóc zmniejszyć stan zapalny i promować lepszą komunikację między komórkami mózgowymi¹²
Zapewnienie odpowiedniej ilości snu – regularny rytm snu i dbanie o jego jakość pomaga wypłukiwać toksyny z mózgu i zapobiegać gromadzeniu się szkodliwych złogów¹²
Minimalizacja stresu – właściwe zarządzanie stresem może pomóc spowolnić kurczenie się kluczowych obszarów mózgu odpowiedzialnych za pamięć i chronić wzrost komórek nerwowych¹²³
Kontrolowanie spożycia alkoholu – ograniczenie spożycia alkoholu zgodnie z zaleceniami zdrowotnymi¹²

Stymulacja poznawcza i społeczna

Aktywność umysłowa i społeczna odgrywa istotną rolę w profilaktyce otępienia z ciałami Lewy’ego¹²:

Utrzymywanie aktywności umysłowej – czytanie, rozwiązywanie krzyżówek, nauka nowego języka czy gra na instrumencie muzycznym może wzmacniać funkcje poznawcze¹²³
Aktywność społeczna – spędzanie czasu z innymi ludźmi, bezpośrednie kontakty społeczne, utrzymywanie relacji z przyjaciółmi i rodziną oraz rozwijanie hobby mogą poprawić funkcje poznawcze i ogólne samopoczucie¹²³

Kontrola chorób współistniejących

Regularne monitorowanie i leczenie chorób współistniejących może pomóc zmniejszyć ryzyko rozwoju otępienia z ciałami Lewy’ego¹²:

Regularne kontrolowanie ciśnienia krwi i poziomu cholesterolu¹
Kontrola poziomu glukozy we krwi u osób z cukrzycą typu 2¹²
Utrzymywanie prawidłowej masy ciała¹
Regularne badania słuchu¹
Leczenie depresji i innych zaburzeń psychicznych¹

Obecne badania nad zapobieganiem otępieniu z ciałami Lewy’ego

Inhibitory cholinoesterazy

Badacze z Instytutu Karolinska wykazali, że leki stosowane w chorobie Alzheimera, zwane inhibitorami cholinoesterazy, mogą pomagać w spowolnieniu pogorszenia funkcji poznawczych u osób z otępieniem z ciałami Lewy’ego w okresie pięciu lat¹. Naukowcy donoszą również, że stosowanie inhibitorów cholinoesterazy wiązało się ze zmniejszonym ryzykiem śmiertelności w pierwszym roku po diagnozie otępienia z ciałami Lewy’ego².

Obecnie nie ma zatwierdzonych przez FDA leków specyficznie do leczenia otępienia z ciałami Lewy’ego, dlatego lekarze często stosują leki przeznaczone do leczenia choroby Alzheimera, takie jak inhibitory cholinoesterazy i memantyna, w celu łagodzenia objawów¹. Analizy wykazały, że stosowanie inhibitorów cholinoesterazy znacząco spowolniło pogorszenie funkcji poznawczych u uczestników badania z otępieniem z ciałami Lewy’ego w ciągu pięcioletniego okresu, w porównaniu do osób przyjmujących memantynę lub nieprzyjmujących żadnego leczenia².

Leki stosowane w leczeniu prostaty

Nowe badania z Uniwersytetu Iowa wskazują, że leki stosowane w leczeniu przerostu prostaty mogą dostarczyć wskazówek do przyszłych strategii zapobiegania otępieniu z ciałami Lewy’ego¹. Naukowcy donoszą, że mężczyźni przyjmujący trzy powszechnie przepisywane leki na prostatę mogą obniżyć ryzyko rozwoju otępienia z ciałami Lewy’ego¹.

Po uwzględnieniu wieku i innych chorób, zespół badawczy odkrył, że mężczyźni przyjmujący terazosynę, doksazosynę lub alfuzosynę mieli o 40% mniejsze prawdopodobieństwo rozwoju otępienia z ciałami Lewy’ego niż uczestnicy przyjmujący tamsulozynę i o 37% mniejsze prawdopodobieństwo niż osoby przyjmujące 5-alfa-reduktazy (5ARIs)². Wyniki te są obiecujące, sugerując, że niektóre powszechnie stosowane leki na prostatę mogą potencjalnie oferować efekt ochronny przed otępieniem z ciałami Lewy’ego¹.

Badania nad układem immunologicznym

Nowe informacje o procesie chorobowym mogą pomóc badaczom znaleźć skuteczne metody leczenia otępienia z ciałami Lewy’ego¹. Na przykład, terapie obecnie stosowane w niektórych chorobach autoimmunologicznych mogą wyłączyć mechanizm CXCR4-CXCL12 i zapobiec wnikaniu określonych komórek T do mózgu, co mogłoby ochronić neurony przed zniszczeniem².

Zapobieganie upadkom u osób z otępieniem z ciałami Lewy’ego

Chociaż upadków nie zawsze można uniknąć, aktywne działania prewencyjne są niezwykle istotne w opiece nad osobami z otępieniem z ciałami Lewy’ego¹. Stan zdrowia osoby z DLB zależy od zapobiegania upadkom i wynikającej z nich utraty mobilności, zmniejszonej aktywności, urazów, wizyt w szpitalu, a następnie problemów behawioralnych, majaczenia i potencjalnie poważniejszych konsekwencji².

Eksperci zalecają agresywne zapobieganie upadkom, ponieważ nawet u osób, które nie są wątłe, upadki mogą prowadzić do katastrofalnych skutków. Problemy behawioralne często wynikają z bólu, zmniejszonej mobilności i braku ćwiczeń w okresie rekonwalescencji³.

Modyfikacje środowiska domowego

Zalecane są następujące modyfikacje środowiska domowego w celu zapobiegania upadkom¹:

Analiza podłóg pod kątem ryzyka stwarzanego przez połączenia różnych powierzchni podłogowych, takich jak przejścia z płytek na drewno, wykładzinę czy dywaniki¹
Unikanie wykładzin i dywaników, które mogą zwiększać ryzyko potknięć²
Konsultacja z terapeutą zajęciowym w celu oceny przestrzeni mieszkalnej i zaproponowania możliwych rozwiązań³
Ograniczenie konieczności korzystania ze schodów, na ile to możliwe⁴
Utrzymywanie oświetlenia lub instalacja aktywowanych ruchem lampek nocnych w obszarach, które są przemierzane w ciemności⁵

Kompleksowe podejście do profilaktyki otępienia z ciałami Lewy’ego

Chociaż obecnie nie ma znanego sposobu na zapobieganie otępieniu z ciałami Lewy’ego, zachowanie czujności na objawy i oznaki może umożliwić wcześniejszą diagnozę i leczenie¹. Odpowiednie leczenie może spowolnić lub złagodzić objawy u niektórych osób².

Badania nad otępieniem z ciałami Lewy’ego, chorobą Alzheimera i otępieniem w chorobie Parkinsona są w toku. Opracowywane są nowe leki i badane nowe podejścia terapeutyczne¹. Badania kliniczne są kluczem do odkrycia przyszłych metod leczenia i strategii zapobiegawczych dla otępienia z ciałami Lewy’ego¹.

W przypadku obaw dotyczących ryzyka rozwoju otępienia lub któregokolwiek z wymienionych czynników ryzyka, zaleca się rozmowę z lekarzem na temat sposobów ich kontrolowania¹. Wczesna diagnoza i interwencja mogą przyczynić się do poprawy jakości życia pacjentów z otępieniem z ciałami Lewy’ego¹.

Kolejne rozdziały

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Materiały źródłowe

#1 Lewy body dementias – symptoms, causes and treatment | healthdirect
https://www.healthdirect.gov.au/lewy-body-dementias
Lewy body dementias are conditions where round clumps of protein (called Lewy bodies) build up in your brain. […] There is currently no cure for Lewy body dementias, but there are treatments to help with the symptoms. […] No therapies or changes in behaviour can prevent Lewy body dementias. […] In general, you can lower your chance of developing dementia by: eating a healthy, balanced diet, exercising regularly, maintaining contact with your friends and family, doing memory and thinking activities, such as reading, completing crossword puzzles or playing a musical instrument, getting enough sleep.
#1 What Are the Lewy Body Dementia Risk Factors Patients Should Know About? – Altoida
https://altoida.com/blog/what-are-the-lewy-body-dementia-risk-factors-patients-should-know-about/
Although Lewy body dementia risk factors are less established and less understood than risk factors for other neurodegenerative diseases, several potential risk factors have been identified. […] While there are no proven strategies for preventing Lewy body dementia, several aspects of healthy living may reduce the risk of developing dementia. […] Experts recommend: Quitting smoking. Exercising daily (30-60 minutes/day). Eating a heart-healthy diet. Getting adequate sleep. Minimizing stress. Controlling alcohol consumption. […] Additionally, individuals with modifiable Lewy body dementia risk factors, such as hypertension, diabetes, and depression, should closely monitor their brain health while modifying risk factors and making lifestyle changes.
#1 Dementia with Lewy Bodies Risk Factors | Alzheimer’s Research UK
https://www.alzheimersresearchuk.org/dementia-information/types-of-dementia/dementia-with-lewy-bodies/risk-factors/
Age is the biggest known risk factor for the development of Dementia with Lewy bodies. […] While thereâs no guaranteed way to completely prevent dementia with Lewy bodies, evidence suggests that looking after our brain health may reduce our risk of dementia. […] To keep our brains healthy: keep physically and mentally active. donât smoke. have your blood pressure, cholesterol and hearing checked regularly. maintain a healthy weight. eat a healthy balanced diet. reduce alcohol consumption in line with government recommendations. keep blood glucose in check if you have type 2 diabetes. keep socially active by spending time with people and do hobbies you enjoy. […] If you have concerns about your dementia risk or any of the risk factors mentioned here you can speak to your doctor about managing them.
#1 Ask the MD: What Is Lewy Body Dementia? | Parkinson’s Disease
https://www.michaeljfox.org/news/ask-md-what-lewy-body-dementia
While no therapy has yet been proven to prevent Lewy body dementia, some strategies may promote brain health, reduce dementia risk and improve general well-being. Recommendations include: […] Eat a healthy, well-balanced diet […] Exercise regularly […] Interact with others socially […] Stimulate your mind (read, do crossword puzzles, learn a new language) […] Decrease stress […] Keep a regular sleep schedule […] Don’t smoke (or consider quitting) […] Drink alcohol in moderation […] Work with your doctor to ensure all health conditions (diabetes, high blood pressure, etc.) are controlled.
#1 Lewy Body Dementia (LBD): Symptoms, Treatment, and Help
https://www.helpguide.org/aging/dementia/lewy-body-dementia
The same healthy lifestyle changes that are used to prevent dementia can also be useful in slowing the advancement of LBD symptoms. […] Get regular exercise to stimulate your brain’s ability to maintain old connections, make new ones, and slow deterioration of cognitive abilities. […] Social engagement, connecting face-to-face with others, can help improve your cognitive function. […] Eating a brain-healthy diet can help reduce inflammation and promote better communication between brain cells. […] Mental stimulation, learning new things, and challenging your brain can help strengthen your cognitive skills. […] Getting quality sleep can flush out brain toxins and avoid the build-up of damaging plaques. […] Managing stress can help slow shrinking to a key memory area of the brain and protect nerve cell growth. […] To learn more about putting these strategies into action, see Preventing or Slowing Down Alzheimer’s Disease and Dementia.
#1 Lewy body dementia: Can Alzheimerâs drugs help slow cognitive decline?
https://www.medicalnewstoday.com/articles/alzheimers-cholinesterase-inhibitors-slow-cognitive-decline-lewy-body-dementia
There is currently no cure for dementia with Lewy bodies, which is the 2nd most common type of dementia. […] Researchers from the Karolinska Institutet have found that Alzheimers disease medications called cholinesterase inhibitors may help slow down cognitive decline in people with dementia with Lewy bodies over five years. […] Scientists also report that the use of cholinesterase inhibitors was linked with a reduced mortality risk in the first year after a Lewy body dementia diagnosis. […] There are currently no approved treatments for dementia with Lewy bodies, so doctors often use drugs for Alzheimers disease, such as cholinesterase inhibitors and memantine, for symptom relief. […] Upon analysis, researchers found that the use of cholinesterase inhibitors significantly slowed cognitive decline in participants with dementia with Lewy bodies over a five-year period, compared to those prescribed memantine or no treatment.
#1 Research – Lewy Body Dementia Association
https://www.lbda.org/research/
Clinical trials are the key to unlocking future treatments and preventive strategies for Lewy body dementia (LBD). […] According to new research from the University of Iowa, medications used for prostate enlargement may provide clues to future strategies to prevent dementia with Lewy bodies (DLB).
#1 Dementia with Lewy bodies: Can some prostate drugs help lower risk?
https://www.medicalnewstoday.com/articles/prostate-drugs-like-terazosin-may-help-lower-dementia-with-lewy-bodies-risk
Dementia with Lewy bodies is the second most common neurodegenerative dementia affecting older adults. […] There is currently no cure for dementia with Lewy bodies. […] New therapies are needed to help prevent the development of this condition. […] Researchers from the University of Iowa report that males taking three commonly prescribed prostate medications may lower their risk of developing dementia with Lewy bodies. […] We need to find a way to slow the progression or prevent the development of dementia with Lewy bodies, Simmering told Medical News Today. […] After factoring in age and other health conditions, Simmering and his team discovered that male participants taking terazosin, doxazosin, or alfuzosin were 40% less likely to develop dementia with Lewy bodies than participants taking tamsulosin, and 37% less likely than those taking the 5ARIs.
#1 Dementia with Lewy bodies: Can some prostate drugs help lower risk?
https://www.medicalnewstoday.com/articles/prostate-drugs-like-terazosin-may-help-lower-dementia-with-lewy-bodies-risk
The findings are promising, suggesting that certain commonly used prostate drugs could potentially offer a protective effect against dementia with Lewy bodies. […] Given the significant impact dementia with Lewy bodies has on patients quality of life and the current lack of effective preventive treatments, this study opens a potential new avenue for reducing the risk of this debilitating disease. […] Currently, there are no drugs specifically approved to prevent or treat dementia with Lewy bodies effectively. […] Finding new methods or repurposing existing drugs could help to address this significant therapeutic gap. […] Preventive strategies could potentially reduce these costs. Identifying ways to reduce the risk of dementia with Lewy bodies can greatly enhance the quality of life for at-risk populations, preserving cognitive function and independence for a longer period, explained the specialist.
#1 Immune system may play harmful role in Lewy body dementia
https://www.alzheimers.gov/news/immune-system-may-play-harmful-role-lewy-body-dementia
This new information about the disease process could help investigators find effective treatments for Lewy body dementia. […] For example, therapies currently used for certain autoimmune diseases can turn off the CXCR4-CXCL12 mechanism and may prevent these specific T cells from entering the brain to destroy neurons. […] 5.E, Develop disease-modifying interventions for LBD based on discovering biomarkers, molecular targets, and genetic and environmental modifiers that enhance, delay, or prevent the onset of disease.
#1 Avoid Falls Caused by Lewy Body Dementia! – Lewy Body Dementia Canada
https://www.lewybodydementia.ca/avoid-falls-caused-by-lewy-body-dementia/
Falls cannot always be avoided, but whatever can be done to avoid them is well worth almost any effort. […] The condition of your loved one with Lewy Body Dementia (LBD) depends upon the prevention of falls and the resulting loss of mobility, diminished activity levels, trauma, hospital visits, and the ensuing behavioral problems, delirium, and, potentially, worse. […] Aggressively prevent falls! […] If your loved one is not frail, the falls can still result in a catastrophe. Behavioural problems frequently result from pain, reduced mobility and lack of exercise during the recovery period. […] Testing it on your loved one is dangerous, of course, even if you are highly attentive to making sure there is something safe, soft and solid to land upon when the person does lose their balance.
#1 Avoid Falls Caused by Lewy Body Dementia! – Lewy Body Dementia Canada
https://www.lewybodydementia.ca/avoid-falls-caused-by-lewy-body-dementia/
Analyze the floors and whether there are risks created by the junctions of different flooring surfaces, such as tile to hardwood to carpet to area rugs. […] The potential for distracting or confusing hallucinations increases with the progress of LBD. […] Many Occupational Therapists (OT) say to avoid broadloom and area rugs. […] Ask an OT to assess your living spaces, and suggest options. […] Reduce the need to use stairs as much as possible. […] Keep a light on, or install motion-activated night lights in areas that are traversed in darkness. […] If so, you need constant vigilance: aggressively prevent falls!
#1 Lewy Body Dementia (LBD) Diagnosis, Prognosis, Causes & Treatment
https://www.emedicinehealth.com/dementia_with_lewy_bodies/article_em.htm
How Do You Prevent Dementia with Lewy Bodies? There is no known way to prevent dementia with Lewy bodies. Being alert for symptoms and signs may allow earlier diagnosis and treatment. Appropriate treatment can slow or relieve symptoms in some people.
#1 Lewy Body Dementia (LBD): What It Is, Symptoms & Treatment
https://my.clevelandclinic.org/health/diseases/17815-lewy-body-dementia
Currently, theres no known way to prevent Lewy body dementia (LBD). […] However, theres always hope. Research on dementia with Lewy bodies, Alzheimers disease and Parkinsons disease with dementia are ongoing. New medications are being developed and new treatment approaches are being investigated.
#2 Lewy body dementia: Can Alzheimerâs drugs help slow cognitive decline?
https://www.medicalnewstoday.com/articles/alzheimers-cholinesterase-inhibitors-slow-cognitive-decline-lewy-body-dementia
There is currently no cure for dementia with Lewy bodies, which is the 2nd most common type of dementia. […] Researchers from the Karolinska Institutet have found that Alzheimers disease medications called cholinesterase inhibitors may help slow down cognitive decline in people with dementia with Lewy bodies over five years. […] Scientists also report that the use of cholinesterase inhibitors was linked with a reduced mortality risk in the first year after a Lewy body dementia diagnosis. […] There are currently no approved treatments for dementia with Lewy bodies, so doctors often use drugs for Alzheimers disease, such as cholinesterase inhibitors and memantine, for symptom relief. […] Upon analysis, researchers found that the use of cholinesterase inhibitors significantly slowed cognitive decline in participants with dementia with Lewy bodies over a five-year period, compared to those prescribed memantine or no treatment.
#2 Dementia with Lewy Bodies Risk Factors | Alzheimer’s Research UK
https://www.alzheimersresearchuk.org/dementia-information/types-of-dementia/dementia-with-lewy-bodies/risk-factors/
Age is the biggest known risk factor for the development of Dementia with Lewy bodies. […] While thereâs no guaranteed way to completely prevent dementia with Lewy bodies, evidence suggests that looking after our brain health may reduce our risk of dementia. […] To keep our brains healthy: keep physically and mentally active. donât smoke. have your blood pressure, cholesterol and hearing checked regularly. maintain a healthy weight. eat a healthy balanced diet. reduce alcohol consumption in line with government recommendations. keep blood glucose in check if you have type 2 diabetes. keep socially active by spending time with people and do hobbies you enjoy. […] If you have concerns about your dementia risk or any of the risk factors mentioned here you can speak to your doctor about managing them.
#2 Lewy Body Dementia (LBD): What It Is, Symptoms & Treatment
https://my.clevelandclinic.org/health/diseases/17815-lewy-body-dementia
Currently, theres no known way to prevent Lewy body dementia (LBD). […] However, theres always hope. Research on dementia with Lewy bodies, Alzheimers disease and Parkinsons disease with dementia are ongoing. New medications are being developed and new treatment approaches are being investigated.
#2 Ask the MD: What Is Lewy Body Dementia? | Parkinson’s Disease
https://www.michaeljfox.org/news/ask-md-what-lewy-body-dementia
While no therapy has yet been proven to prevent Lewy body dementia, some strategies may promote brain health, reduce dementia risk and improve general well-being. Recommendations include: […] Eat a healthy, well-balanced diet […] Exercise regularly […] Interact with others socially […] Stimulate your mind (read, do crossword puzzles, learn a new language) […] Decrease stress […] Keep a regular sleep schedule […] Don’t smoke (or consider quitting) […] Drink alcohol in moderation […] Work with your doctor to ensure all health conditions (diabetes, high blood pressure, etc.) are controlled.
#2 What Are the Lewy Body Dementia Risk Factors Patients Should Know About? – Altoida
https://altoida.com/blog/what-are-the-lewy-body-dementia-risk-factors-patients-should-know-about/
Although Lewy body dementia risk factors are less established and less understood than risk factors for other neurodegenerative diseases, several potential risk factors have been identified. […] While there are no proven strategies for preventing Lewy body dementia, several aspects of healthy living may reduce the risk of developing dementia. […] Experts recommend: Quitting smoking. Exercising daily (30-60 minutes/day). Eating a heart-healthy diet. Getting adequate sleep. Minimizing stress. Controlling alcohol consumption. […] Additionally, individuals with modifiable Lewy body dementia risk factors, such as hypertension, diabetes, and depression, should closely monitor their brain health while modifying risk factors and making lifestyle changes.
#2 Lewy Body Dementia (LBD): Symptoms, Treatment, and Help
https://www.helpguide.org/aging/dementia/lewy-body-dementia
The same healthy lifestyle changes that are used to prevent dementia can also be useful in slowing the advancement of LBD symptoms. […] Get regular exercise to stimulate your brain’s ability to maintain old connections, make new ones, and slow deterioration of cognitive abilities. […] Social engagement, connecting face-to-face with others, can help improve your cognitive function. […] Eating a brain-healthy diet can help reduce inflammation and promote better communication between brain cells. […] Mental stimulation, learning new things, and challenging your brain can help strengthen your cognitive skills. […] Getting quality sleep can flush out brain toxins and avoid the build-up of damaging plaques. […] Managing stress can help slow shrinking to a key memory area of the brain and protect nerve cell growth. […] To learn more about putting these strategies into action, see Preventing or Slowing Down Alzheimer’s Disease and Dementia.
#2 Lewy body dementias – symptoms, causes and treatment | healthdirect
https://www.healthdirect.gov.au/lewy-body-dementias
Lewy body dementias are conditions where round clumps of protein (called Lewy bodies) build up in your brain. […] There is currently no cure for Lewy body dementias, but there are treatments to help with the symptoms. […] No therapies or changes in behaviour can prevent Lewy body dementias. […] In general, you can lower your chance of developing dementia by: eating a healthy, balanced diet, exercising regularly, maintaining contact with your friends and family, doing memory and thinking activities, such as reading, completing crossword puzzles or playing a musical instrument, getting enough sleep.
#2
https://www.prevention.com/health/health-conditions/a38191477/lewy-body-dementia-symptoms/
Theres no proven way to prevent the onset of LBD or any form of dementia, but there are certain lifestyle habits you can adopt to boost your brain health for as long as possible, according to Dr. Caccappolo. […] These include decreasing/managing stress as much as possible, following a regular sleep routine, maintaining a healthy diet, exercising when possible, staying socially and intellectually active, and managing overall health, she says.
#2 Lewy body dementia: Can Alzheimerâs drugs help slow cognitive decline?
https://www.medicalnewstoday.com/articles/alzheimers-cholinesterase-inhibitors-slow-cognitive-decline-lewy-body-dementia
Additionally, scientists linked taking cholinesterase inhibitors with a reduced risk of death in the first year after a Lewy body dementia diagnosis. […] Our results highlight the potential benefits of cholinesterase inhibitors for patients with dementia with Lewy bodies and support updating treatment guidelines. […] Because there are no FDA approved medications for Lewy body dementia, many medical providers have needed to go for off label prescription management of the condition which has included cholinesterase inhibitors. […] Lewy body dementia is quite prevalent, probably the most underdiagnosed subtype of dementia and with no current FDA approved medications to slow or help manage symptoms we are in desperate need of new treatment options. […] In our specialty memory clinic, we already routinely prescribe cholinesterase inhibitors to patients diagnosed with Lewy Body Disease and related dementias. […] Such findings help spread the word to primary care clinics and to families directly that these drugs can significantly benefit DLB patients.
#2 Dementia with Lewy bodies: Can some prostate drugs help lower risk?
https://www.medicalnewstoday.com/articles/prostate-drugs-like-terazosin-may-help-lower-dementia-with-lewy-bodies-risk
Dementia with Lewy bodies is the second most common neurodegenerative dementia affecting older adults. […] There is currently no cure for dementia with Lewy bodies. […] New therapies are needed to help prevent the development of this condition. […] Researchers from the University of Iowa report that males taking three commonly prescribed prostate medications may lower their risk of developing dementia with Lewy bodies. […] We need to find a way to slow the progression or prevent the development of dementia with Lewy bodies, Simmering told Medical News Today. […] After factoring in age and other health conditions, Simmering and his team discovered that male participants taking terazosin, doxazosin, or alfuzosin were 40% less likely to develop dementia with Lewy bodies than participants taking tamsulosin, and 37% less likely than those taking the 5ARIs.
#2 Immune system may play harmful role in Lewy body dementia
https://www.alzheimers.gov/news/immune-system-may-play-harmful-role-lewy-body-dementia
This new information about the disease process could help investigators find effective treatments for Lewy body dementia. […] For example, therapies currently used for certain autoimmune diseases can turn off the CXCR4-CXCL12 mechanism and may prevent these specific T cells from entering the brain to destroy neurons. […] 5.E, Develop disease-modifying interventions for LBD based on discovering biomarkers, molecular targets, and genetic and environmental modifiers that enhance, delay, or prevent the onset of disease.
#2 Avoid Falls Caused by Lewy Body Dementia! – Lewy Body Dementia Canada
https://www.lewybodydementia.ca/avoid-falls-caused-by-lewy-body-dementia/
Falls cannot always be avoided, but whatever can be done to avoid them is well worth almost any effort. […] The condition of your loved one with Lewy Body Dementia (LBD) depends upon the prevention of falls and the resulting loss of mobility, diminished activity levels, trauma, hospital visits, and the ensuing behavioral problems, delirium, and, potentially, worse. […] Aggressively prevent falls! […] If your loved one is not frail, the falls can still result in a catastrophe. Behavioural problems frequently result from pain, reduced mobility and lack of exercise during the recovery period. […] Testing it on your loved one is dangerous, of course, even if you are highly attentive to making sure there is something safe, soft and solid to land upon when the person does lose their balance.
#2 Avoid Falls Caused by Lewy Body Dementia! – Lewy Body Dementia Canada
https://www.lewybodydementia.ca/avoid-falls-caused-by-lewy-body-dementia/
Analyze the floors and whether there are risks created by the junctions of different flooring surfaces, such as tile to hardwood to carpet to area rugs. […] The potential for distracting or confusing hallucinations increases with the progress of LBD. […] Many Occupational Therapists (OT) say to avoid broadloom and area rugs. […] Ask an OT to assess your living spaces, and suggest options. […] Reduce the need to use stairs as much as possible. […] Keep a light on, or install motion-activated night lights in areas that are traversed in darkness. […] If so, you need constant vigilance: aggressively prevent falls!
#2 Lewy Body Dementia (LBD) Diagnosis, Prognosis, Causes & Treatment
https://www.emedicinehealth.com/dementia_with_lewy_bodies/article_em.htm
How Do You Prevent Dementia with Lewy Bodies? There is no known way to prevent dementia with Lewy bodies. Being alert for symptoms and signs may allow earlier diagnosis and treatment. Appropriate treatment can slow or relieve symptoms in some people.
#3 Dementia with Lewy bodies: Can some prostate drugs help lower risk?
https://www.medicalnewstoday.com/articles/prostate-drugs-like-terazosin-may-help-lower-dementia-with-lewy-bodies-risk
Dementia with Lewy bodies is the second most common neurodegenerative dementia affecting older adults. […] There is currently no cure for dementia with Lewy bodies. […] New therapies are needed to help prevent the development of this condition. […] Researchers from the University of Iowa report that males taking three commonly prescribed prostate medications may lower their risk of developing dementia with Lewy bodies. […] We need to find a way to slow the progression or prevent the development of dementia with Lewy bodies, Simmering told Medical News Today. […] After factoring in age and other health conditions, Simmering and his team discovered that male participants taking terazosin, doxazosin, or alfuzosin were 40% less likely to develop dementia with Lewy bodies than participants taking tamsulosin, and 37% less likely than those taking the 5ARIs.
#3 What Are the Lewy Body Dementia Risk Factors Patients Should Know About? – Altoida
https://altoida.com/blog/what-are-the-lewy-body-dementia-risk-factors-patients-should-know-about/
Although Lewy body dementia risk factors are less established and less understood than risk factors for other neurodegenerative diseases, several potential risk factors have been identified. […] While there are no proven strategies for preventing Lewy body dementia, several aspects of healthy living may reduce the risk of developing dementia. […] Experts recommend: Quitting smoking. Exercising daily (30-60 minutes/day). Eating a heart-healthy diet. Getting adequate sleep. Minimizing stress. Controlling alcohol consumption. […] Additionally, individuals with modifiable Lewy body dementia risk factors, such as hypertension, diabetes, and depression, should closely monitor their brain health while modifying risk factors and making lifestyle changes.
#3 Lewy Body Dementia (LBD): What It Is, Symptoms & Treatment
https://my.clevelandclinic.org/health/diseases/17815-lewy-body-dementia
Currently, theres no known way to prevent Lewy body dementia (LBD). […] However, theres always hope. Research on dementia with Lewy bodies, Alzheimers disease and Parkinsons disease with dementia are ongoing. New medications are being developed and new treatment approaches are being investigated.
#3 Lewy Body Dementia (LBD): Symptoms, Treatment, and Help
https://www.helpguide.org/aging/dementia/lewy-body-dementia
The same healthy lifestyle changes that are used to prevent dementia can also be useful in slowing the advancement of LBD symptoms. […] Get regular exercise to stimulate your brain’s ability to maintain old connections, make new ones, and slow deterioration of cognitive abilities. […] Social engagement, connecting face-to-face with others, can help improve your cognitive function. […] Eating a brain-healthy diet can help reduce inflammation and promote better communication between brain cells. […] Mental stimulation, learning new things, and challenging your brain can help strengthen your cognitive skills. […] Getting quality sleep can flush out brain toxins and avoid the build-up of damaging plaques. […] Managing stress can help slow shrinking to a key memory area of the brain and protect nerve cell growth. […] To learn more about putting these strategies into action, see Preventing or Slowing Down Alzheimer’s Disease and Dementia.
#3
https://www.prevention.com/health/health-conditions/a38191477/lewy-body-dementia-symptoms/
Theres no proven way to prevent the onset of LBD or any form of dementia, but there are certain lifestyle habits you can adopt to boost your brain health for as long as possible, according to Dr. Caccappolo. […] These include decreasing/managing stress as much as possible, following a regular sleep routine, maintaining a healthy diet, exercising when possible, staying socially and intellectually active, and managing overall health, she says.
#3 Lewy body dementias – symptoms, causes and treatment | healthdirect
https://www.healthdirect.gov.au/lewy-body-dementias
Lewy body dementias are conditions where round clumps of protein (called Lewy bodies) build up in your brain. […] There is currently no cure for Lewy body dementias, but there are treatments to help with the symptoms. […] No therapies or changes in behaviour can prevent Lewy body dementias. […] In general, you can lower your chance of developing dementia by: eating a healthy, balanced diet, exercising regularly, maintaining contact with your friends and family, doing memory and thinking activities, such as reading, completing crossword puzzles or playing a musical instrument, getting enough sleep.
#3 Dementia with Lewy Bodies Risk Factors | Alzheimer’s Research UK
https://www.alzheimersresearchuk.org/dementia-information/types-of-dementia/dementia-with-lewy-bodies/risk-factors/
Age is the biggest known risk factor for the development of Dementia with Lewy bodies. […] While thereâs no guaranteed way to completely prevent dementia with Lewy bodies, evidence suggests that looking after our brain health may reduce our risk of dementia. […] To keep our brains healthy: keep physically and mentally active. donât smoke. have your blood pressure, cholesterol and hearing checked regularly. maintain a healthy weight. eat a healthy balanced diet. reduce alcohol consumption in line with government recommendations. keep blood glucose in check if you have type 2 diabetes. keep socially active by spending time with people and do hobbies you enjoy. […] If you have concerns about your dementia risk or any of the risk factors mentioned here you can speak to your doctor about managing them.
#3 Avoid Falls Caused by Lewy Body Dementia! – Lewy Body Dementia Canada
https://www.lewybodydementia.ca/avoid-falls-caused-by-lewy-body-dementia/
Falls cannot always be avoided, but whatever can be done to avoid them is well worth almost any effort. […] The condition of your loved one with Lewy Body Dementia (LBD) depends upon the prevention of falls and the resulting loss of mobility, diminished activity levels, trauma, hospital visits, and the ensuing behavioral problems, delirium, and, potentially, worse. […] Aggressively prevent falls! […] If your loved one is not frail, the falls can still result in a catastrophe. Behavioural problems frequently result from pain, reduced mobility and lack of exercise during the recovery period. […] Testing it on your loved one is dangerous, of course, even if you are highly attentive to making sure there is something safe, soft and solid to land upon when the person does lose their balance.
#3 Avoid Falls Caused by Lewy Body Dementia! – Lewy Body Dementia Canada
https://www.lewybodydementia.ca/avoid-falls-caused-by-lewy-body-dementia/
Analyze the floors and whether there are risks created by the junctions of different flooring surfaces, such as tile to hardwood to carpet to area rugs. […] The potential for distracting or confusing hallucinations increases with the progress of LBD. […] Many Occupational Therapists (OT) say to avoid broadloom and area rugs. […] Ask an OT to assess your living spaces, and suggest options. […] Reduce the need to use stairs as much as possible. […] Keep a light on, or install motion-activated night lights in areas that are traversed in darkness. […] If so, you need constant vigilance: aggressively prevent falls!
#4 Avoid Falls Caused by Lewy Body Dementia! – Lewy Body Dementia Canada
https://www.lewybodydementia.ca/avoid-falls-caused-by-lewy-body-dementia/
Analyze the floors and whether there are risks created by the junctions of different flooring surfaces, such as tile to hardwood to carpet to area rugs. […] The potential for distracting or confusing hallucinations increases with the progress of LBD. […] Many Occupational Therapists (OT) say to avoid broadloom and area rugs. […] Ask an OT to assess your living spaces, and suggest options. […] Reduce the need to use stairs as much as possible. […] Keep a light on, or install motion-activated night lights in areas that are traversed in darkness. […] If so, you need constant vigilance: aggressively prevent falls!
#5 Avoid Falls Caused by Lewy Body Dementia! – Lewy Body Dementia Canada
https://www.lewybodydementia.ca/avoid-falls-caused-by-lewy-body-dementia/
Analyze the floors and whether there are risks created by the junctions of different flooring surfaces, such as tile to hardwood to carpet to area rugs. […] The potential for distracting or confusing hallucinations increases with the progress of LBD. […] Many Occupational Therapists (OT) say to avoid broadloom and area rugs. […] Ask an OT to assess your living spaces, and suggest options. […] Reduce the need to use stairs as much as possible. […] Keep a light on, or install motion-activated night lights in areas that are traversed in darkness. […] If so, you need constant vigilance: aggressively prevent falls!