Materiały źródłowe

• #1 Gallbladder cancer – Symptoms and causes – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/gallbladder-cancer/symptoms-causes/syc-20353370

  Gallbladder cancer may not be found until it’s advanced because it may cause no symptoms. When they happen, the symptoms may be like those of common conditions. […] Gallbladder cancer may have no symptoms. When there are signs and symptoms, they may include: Belly pain, mostly in the upper right part of the belly. Belly bloating. A mass you can feel through the skin. Losing weight without trying. Yellowing of the skin and whites of the eyes, called jaundice. Yellowing of the skin might be harder to see on Black or brown skin. Jaundice typically happens when the gallbladder cancer is very advanced. […] But most gallbladder cancers are found when they’ve grown beyond the gallbladder. Then the chance to survive, called prognosis, often is poor.

• #2 Gallbladder Cancer: Symptoms, Treatment & Prognosis

  https://my.clevelandclinic.org/health/diseases/17013-gallbladder-cancer

  Gallbladder cancer is a rare form of cancer that often doesnt cause signs or symptoms in the early stages. […] Gallbladder cancer begins in the innermost layer of your gallbladder, called the mucosal layer, and spreads outward. It often doesnt cause signs or symptoms in the early stages. Instead, healthcare providers often find the cancer by chance after gallbladder surgery. […] When symptoms appear, theyre similar to more common conditions, like gallstones or a blockage in a bile duct. […] Symptoms include: Upper abdominal pain. Yellowed skin and yellowed whites of your eyes (jaundice). Lumps in your abdomen. Unexplained weight loss. Nausea and vomiting. Bloating. Fever. […] The prognosis for gallbladder cancer tends to be poor because its not usually diagnosed until its advanced. Only about 20% of gallbladder cancers are diagnosed in the early stages. The five-year survival rate for people with metastasized gallbladder cancer is 2%. The survival rate for localized gallbladder cancer is much higher, at 66%.

• #3 End Stage Gallbladder Cancer: Symptoms, Treatment, Outlook

  https://www.healthline.com/health/cancer/end-stage-gallbladder-cancer-symptoms

  End stage gallbladder cancer is also called stage 4 gallbladder cancer. Symptoms include jaundice, abdominal pain, nausea, and fever. […] Gallbladder cancer often doesn’t cause symptoms in the early stages, which often delays its diagnosis. Only 1 out of 5 gallbladder cancers are discovered in an early stage. Most aren’t found until they’re in an advanced stage. […] Signs and symptoms of gallbladder cancer can include: jaundice, abdominal pain, usually in the upper right part of your abdomen, fever, nausea and vomiting, bloating, a lump or swelling in your abdomen, unintentional weight loss, loss of appetite, itchy skin, dark urine, pale stools. […] End stage gallbladder cancer tends to have a poor outlook, especially if it’s spread to other organs at the time it was diagnosed. […] People with advanced gallbladder cancer have a 5-year relative survival rate of about 3%, according to the ACS.

• #4 Gallbladder Cancer: Symptoms, Treatment & Prognosis

  https://my.clevelandclinic.org/health/diseases/17013-gallbladder-cancer

  Gallbladder cancer is a rare form of cancer that often doesnt cause signs or symptoms in the early stages. […] Gallbladder cancer begins in the innermost layer of your gallbladder, called the mucosal layer, and spreads outward. It often doesnt cause signs or symptoms in the early stages. Instead, healthcare providers often find the cancer by chance after gallbladder surgery. […] When symptoms appear, theyre similar to more common conditions, like gallstones or a blockage in a bile duct. […] Symptoms include: Upper abdominal pain. Yellowed skin and yellowed whites of your eyes (jaundice). Lumps in your abdomen. Unexplained weight loss. Nausea and vomiting. Bloating. Fever. […] The prognosis for gallbladder cancer tends to be poor because its not usually diagnosed until its advanced. Only about 20% of gallbladder cancers are diagnosed in the early stages. The five-year survival rate for people with metastasized gallbladder cancer is 2%. The survival rate for localized gallbladder cancer is much higher, at 66%.

• #5 Signs of Gallbladder Cancer | Symptoms of Gallbladder Cancer | American Cancer Society

  https://www.cancer.org/cancer/types/gallbladder-cancer/detection-diagnosis-staging/signs-and-symptoms.html

  Gallbladder cancer doesn’t usually cause signs or symptoms until later in the course of the disease, when the tumor is large and/or has spread. But sometimes symptoms can appear sooner and lead to an early diagnosis. If the cancer is found at an earlier stage, treatment might work better. […] Some of the more common symptoms of gallbladder cancer include: […] Most people with gallbladder cancer will have belly pain. Most often it’s in the upper right part of the belly. […] Some people with gallbladder cancer sometimes have vomiting as a symptom. […] If the cancer gets big enough to block the bile ducts, bile from the liver cant drain into the intestines. This can cause a greenish-yellow chemical (called bilirubin) in the bile to build up in the blood and settle in different parts of the body. The yellow coloring of jaundice can often be seen in the skin and the white part of the eyes.

• #6 Gallbladder cancer | NHS inform

  https://www.nhsinform.scot/illnesses-and-conditions/cancer/cancer-types-in-adults/gallbladder-cancer/

  In the early stages, gallbladder cancer doesn’t cause symptoms, which means it could be at an advanced stage by the time it’s diagnosed. […] Symptoms that occur at a later stage can include: abdominal (stomach) pain, feeling sick, jaundice (yellowing of the skin and whites of the eyes). […] Other possible symptoms of gallbladder cancer can include loss of appetite, unexplained weight loss and a swollen stomach. […] As with all cancers, the chances of survival depend on how far the condition has advanced when it is diagnosed.

• #7 Symptoms of gallbladder cancer – NHS

  https://www.nhs.uk/conditions/gallbladder-cancer/symptoms/

  Gallbladder cancer may not have any symptoms, or they might be hard to spot. […] Symptoms of gallbladder cancer include: the whites of your eyes turning yellow or your skin turning yellow, which may be less obvious on brown or black skin (jaundice) you may also have itchy skin, darker pee and paler poo than usual […] loss of appetite or losing weight without trying to […] a high temperature, or you feel hot or shivery […] a lump in your tummy. […] Other symptoms can affect your digestion, such as: feeling or being sick […] aching pain in the right side of your tummy, sometimes described as a „dragging feeling” […] sharp pain in your tummy […] a very swollen tummy that’s not related to when you eat. […] You might find you get used to them. But it’s important to be checked by a GP if your symptoms change, get worse, or do not feel normal for you.

• #8 Gallbladder Cancer Treatment – NCI

  https://www.cancer.gov/types/gallbladder/patient/gallbladder-treatment-pdq

  Signs and symptoms of gallbladder cancer include jaundice, fever, and pain. […] Gallbladder cancer is difficult to detect (find) and diagnose early. […] People rarely have signs or symptoms in the early stages of gallbladder cancer. […] The symptoms of gallbladder cancer, when present, are like the symptoms of many other illnesses. […] Gallbladder cancer is sometimes found when the gallbladder is removed for other reasons. […] Gallbladder cancer can be cured only if it is found before it has spread, when it can be removed by surgery. […] If the cancer has spread, palliative treatment can improve the patient’s quality of life by controlling the symptoms and complications of this disease. […] Metastatic gallbladder cancer may spread to surrounding tissues, organs, throughout the abdominal cavity, or to distant parts of the body.

• #9

  https://winshipcancer.emory.edu/cancer-types-and-treatments/gallbladder-cancer/diagnosis.php

  Diagnosing your gallbladder cancer can be challenging. Patients are often asymptomatic, and as many as 70% of gallbladder cancers are discovered postoperatively or after a procedure for another condition. […] Gallbladder cancer symptoms are usually felt only when the cancer has reached an advanced stage. Some of the more common signs and symptoms of gallbladder cancer can include: […] You should speak with your doctor if you are experiencing any of the above symptoms. But keep in mind that gallbladder cancer is rare, and these symptoms are more likely to be caused by something else. […] In later stages, the cancer has grown and possibly spread to other locations in the body such as the liver, lung, bones or lymph nodes.

• #10 Overview & Symptoms – Gallbladder & Bile Duct Cancer  |  Johns Hopkins Pathology

  https://pathology.jhu.edu/gbbd/overview-and-symptoms

  Patients with bile duct cancer most often become symptomatic when the cancer obstructs (blocks) the drainage of bile. Because bile cannot be excreted into the bowel, the bilirubin pigments accumulate in the blood, causing jaundice in 90% of patients. The jaundice is usually associated with itching of the skin (also called „pruritus”). The body compensates partially and excretes some of this bilirubin via the urine, so patients may have dark (cola colored) urine. Because bile cannot reach the intestine, the patient’s stools become white (clay colored). […] Other symptoms result from inflammation secondary to tumor obstruction. Patients with gallbladder cancer may have pain in the right upper portion of the abdomen. This pain is a result of inflammation of the gallbladder (cholecystitis) due to blockage of the cystic duct. In fact, approximately 1% of patients who undergo cholecystectomy for suspected cholecystitis prove to have unsuspected gallbladder carcinoma. Distal bile duct tumors near the ampulla of Vater, the point at which the bile drains into the bowel, obstruct the pancreatic duct and lead to inflammation of the pancreas (pancreatitis). […] Yellowing of the skin or whites of the eyes caused by the accumulation of bile pigments. (usually due to an obstruction of the bile ducts.)

• #11 Gallbladder Cancer: Symptoms, Treatment & Prognosis

  https://my.clevelandclinic.org/health/diseases/17013-gallbladder-cancer

  Gallbladder cancer is a rare form of cancer that often doesnt cause signs or symptoms in the early stages. […] Gallbladder cancer begins in the innermost layer of your gallbladder, called the mucosal layer, and spreads outward. It often doesnt cause signs or symptoms in the early stages. Instead, healthcare providers often find the cancer by chance after gallbladder surgery. […] When symptoms appear, theyre similar to more common conditions, like gallstones or a blockage in a bile duct. […] Symptoms include: Upper abdominal pain. Yellowed skin and yellowed whites of your eyes (jaundice). Lumps in your abdomen. Unexplained weight loss. Nausea and vomiting. Bloating. Fever. […] The prognosis for gallbladder cancer tends to be poor because its not usually diagnosed until its advanced. Only about 20% of gallbladder cancers are diagnosed in the early stages. The five-year survival rate for people with metastasized gallbladder cancer is 2%. The survival rate for localized gallbladder cancer is much higher, at 66%.

• #12 Gallbladder Cancer: Symptoms, Diagnosis & Treatment

  https://cytecare.com/blog/gastrointestinal-cancer/gallbladder-cancer-symptoms-diagnosis-and-treatment/

  Gallbladder cancer symptoms can be vague and may mimic other conditions such as cholelithiasis and cholecystitis. […] By the time it presents in a late stage, the disease is characterized by local invasion, extensive regional lymph node metastasis, and distant metastasis or spread to other organs. […] Signs and symptoms of gallbladder cancer include pain in the upper right part of the belly, gall bladder enlargement, jaundice, swelling in and around the belly, nausea, loss of appetite, weight loss, fever, and itchiness in the skin. […] Advanced stage gallbladder cancer symptoms include jaundice, steady abdominal pain, nausea, bile, vomiting, indigestion, bloating, a lump in the abdomen, fever, loss of appetite, weakness, and unnatural weight loss. […] Gallbladder cancer is curable when detected in its early stages. […] When in its later stages, the patient gets palliative and support care, but with the difficulty of its early detection, gallbladder cancer remains incurable without its surgical removal.

• #13 Gallbladder Cancer Symptoms Don’t Appear Early On

  https://www.verywellhealth.com/gallbladder-cancer-symptoms-514049

  Unfortunately, from a diagnosis standpoint, gallbladder cancer does not often have symptoms in the early, most curable stages of the disease. Many of the signs and symptoms of gallbladder cancer occur when the tumor is already in the advanced stages or when it has spread to nearby organs. […] When present, symptoms of gallbladder cancer may include: […] Abdominal pain: It is estimated that about 50% of people with gallbladder cancer experience abdominal pain as a symptom. This abdominal pain is felt most commonly in the upper right abdomen. […] Loss of appetite: A general loss of appetite often accompanies a diagnosis of gallbladder cancer. […] Vomiting: Vomiting and a general feeling of nausea are fairly common symptoms of gallbladder cancer. […] Weight loss: Unexplained or unintentional weight loss may be the first symptom of gallbladder cancer. Unintentional weight loss is a sign of underlying cancer roughly a third of the time, and of cancers, abdominal cancers such as gallbladder cancer are responsible for around half of these. One study found that 40% of people newly diagnosed with gallbladder cancer had experienced unintentional weight loss.

• #14 Signs of gallbladder cancer | Ada

  https://ada.com/conditions/gallbladder-cancer/

  There are normally no early symptoms of gallbladder cancer, or they may go unnoticed, since many symptoms, such as burping or stomach pain, are non-specific. As a result, the condition is often diagnosed at an advanced stage. Later symptoms include a lump in the upper right part of the abdomen and yellowing of the skin. […] Signs of gallbladder cancer tend to appear when the tumor is fairly large and may have spread. If symptoms do appear sooner, earlier diagnosis can lead to prompt treatment and a better prognosis. […] The most common gallbladder cancer symptoms include: […] Stomach pain: Commonly in the upper right part of the abdomen, often described as a dragging feeling, though it can also be a sharper pain if the tumor blocks the bile duct. Most people with gallbladder cancer will develop stomach pain.

• #15 Signs of Gallbladder Cancer | Symptoms of Gallbladder Cancer | American Cancer Society

  https://www.cancer.org/cancer/types/gallbladder-cancer/detection-diagnosis-staging/signs-and-symptoms.html

  Gallbladder cancer doesn’t usually cause signs or symptoms until later in the course of the disease, when the tumor is large and/or has spread. But sometimes symptoms can appear sooner and lead to an early diagnosis. If the cancer is found at an earlier stage, treatment might work better. […] Some of the more common symptoms of gallbladder cancer include: […] Most people with gallbladder cancer will have belly pain. Most often it’s in the upper right part of the belly. […] Some people with gallbladder cancer sometimes have vomiting as a symptom. […] If the cancer gets big enough to block the bile ducts, bile from the liver cant drain into the intestines. This can cause a greenish-yellow chemical (called bilirubin) in the bile to build up in the blood and settle in different parts of the body. The yellow coloring of jaundice can often be seen in the skin and the white part of the eyes.

• #16 Gallbladder Cancer: Symptoms, Treatment & Prognosis

  https://my.clevelandclinic.org/health/diseases/17013-gallbladder-cancer

  Gallbladder cancer is a rare form of cancer that often doesnt cause signs or symptoms in the early stages. […] Gallbladder cancer begins in the innermost layer of your gallbladder, called the mucosal layer, and spreads outward. It often doesnt cause signs or symptoms in the early stages. Instead, healthcare providers often find the cancer by chance after gallbladder surgery. […] When symptoms appear, theyre similar to more common conditions, like gallstones or a blockage in a bile duct. […] Symptoms include: Upper abdominal pain. Yellowed skin and yellowed whites of your eyes (jaundice). Lumps in your abdomen. Unexplained weight loss. Nausea and vomiting. Bloating. Fever. […] The prognosis for gallbladder cancer tends to be poor because its not usually diagnosed until its advanced. Only about 20% of gallbladder cancers are diagnosed in the early stages. The five-year survival rate for people with metastasized gallbladder cancer is 2%. The survival rate for localized gallbladder cancer is much higher, at 66%.

• #17 Symptoms of gallbladder cancer | Cancer Research UK

  https://www.cancerresearchuk.org/about-cancer/gallbladder-cancer/symptoms

  Gallbladder cancer doesn’t usually cause symptoms in the early stages. When you do have symptoms, they can include: tummy (abdominal) pain, feeling sick, yellowing of the skin and whites of the eyes (jaundice), an enlarged gallbladder, weight loss. […] Gallbladder cancer is often diagnosed at a more advanced stage than some other types of cancer. At diagnosis, it may have spread outside the gallbladder to areas nearby. […] You may get a number of symptoms with gallbladder cancer. Most of these happen in the later stages of the disease. […] You can get an aching feeling on your right side if you have gallbladder cancer. Some people describe it as a dragging feeling. If the cancer or gallstones block the bile duct, you will have a sharper pain. […] This is very common in the later stages of gallbladder cancer. Over half the people diagnosed with gallbladder cancer will feel or be sick quite often at some stage of their illness.

• #18 Signs of gallbladder cancer | Ada

  https://ada.com/conditions/gallbladder-cancer/

  Nausea and/or vomiting: This symptom is common in the later stages of gallbladder cancer. […] Yellowing of the skin and whites of the eyes, known as jaundice: This occurs if the tumor grows big enough to block the bile ducts, which normally drain bile from the liver into the intestines. This can lead to a yellowish chemical found in bile, called bilirubin, building up in the blood and settling in different areas of the body. […] Lumps on the right side of the stomach: The gallbladder may swell if the tumor blocks the bile ducts. Gallbladder cancer may also spread to nearby parts of the liver, which may also present as lumps. […] Less common signs of gallbladder cancer may include: Loss of appetite and/or weight, Indigestion, such as bloating and burping, Swollen stomach, Fever, Itchiness, Dark urine, Greasy or light-colored feces. […] These symptoms are much more likely to be caused by other conditions, as gallbladder cancer is rare. For instance, hepatitis is a common cause of jaundice. However, if any of these symptoms are present, it is important to seek medical attention as soon as possible to treat the underlying cause.

• #19 Is gallbladder cancer painful? Expectations and treatment options

  https://www.medicalnewstoday.com/articles/is-gallbladder-cancer-painful

  Gallbladder cancer may not cause symptoms in the early stages of the disease. However, pain is a common symptom of gallbladder cancer during the advanced stages. […] Pain from gallbladder cancer may be an aching, dragging sensation in the upper right belly. Some people also describe it as feeling sharp. The pain can vary in intensity and duration.

• #20 Is gallbladder cancer painful? Expectations and treatment options

  https://www.medicalnewstoday.com/articles/is-gallbladder-cancer-painful

  Although gallbladder cancer can be asymptomatic, some people may experience abdominal pain. […] Symptoms typically occur during more advanced stages of the cancer. Most people with gallbladder cancer will experience abdominal pain. […] However, abdominal pain is one of the most common symptoms of gallbladder cancer as the condition progresses. […] A 2019 study found that, from a sample size of 62 people with a recent gallbladder cancer diagnosis, 92% experienced pain as a symptom. […] Pain may occur due to the growth of cancer cells stretching the liver and other organs. If the cancer grows large enough, it may block the bile duct of the gallbladder, which can cause further pain. […] The outlook for gallbladder cancer can depend on factors such as its type and stage. Pain and other symptoms typically occur as gallbladder cancer progresses, not in the early stages.

• #21 End Stage Gallbladder Cancer Symptoms: Signs to Watch For

  https://cancercenterforhealing.com/end-stage-gallbladder-cancer-symptoms/

  One of the most common symptoms of end stage gallbladder cancer is persistent abdominal pain that can be dull, achy, or sharp. The pain may be felt in the upper right side of the abdomen and may extend to the back or shoulder blades. Pain may worsen after meals or with movement, making it difficult to perform daily activities. […] Unexplained weight loss is another symptom commonly seen in individuals with advanced gallbladder cancer. This is due to the bodys inability to absorb nutrients from food, resulting in weight loss despite adequate calorie intake. Additionally, persistent abdominal pain can decrease a persons appetite, leading to further weight loss. […] As the cancer spreads and affects the liver, jaundice may occur. This is a medical condition that causes yellowing of the skin and the whites of the eyes. Jaundice can also cause dark urine and pale-colored stools.

• #22 Gallbladder cancer – Symptoms and causes – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/gallbladder-cancer/symptoms-causes/syc-20353370

  Gallbladder cancer may not be found until it’s advanced because it may cause no symptoms. When they happen, the symptoms may be like those of common conditions. […] Gallbladder cancer may have no symptoms. When there are signs and symptoms, they may include: Belly pain, mostly in the upper right part of the belly. Belly bloating. A mass you can feel through the skin. Losing weight without trying. Yellowing of the skin and whites of the eyes, called jaundice. Yellowing of the skin might be harder to see on Black or brown skin. Jaundice typically happens when the gallbladder cancer is very advanced. […] But most gallbladder cancers are found when they’ve grown beyond the gallbladder. Then the chance to survive, called prognosis, often is poor.

• #23 Symptoms of gallbladder cancer – NHS

  https://www.nhs.uk/conditions/gallbladder-cancer/symptoms/

  Gallbladder cancer may not have any symptoms, or they might be hard to spot. […] Symptoms of gallbladder cancer include: the whites of your eyes turning yellow or your skin turning yellow, which may be less obvious on brown or black skin (jaundice) you may also have itchy skin, darker pee and paler poo than usual […] loss of appetite or losing weight without trying to […] a high temperature, or you feel hot or shivery […] a lump in your tummy. […] Other symptoms can affect your digestion, such as: feeling or being sick […] aching pain in the right side of your tummy, sometimes described as a „dragging feeling” […] sharp pain in your tummy […] a very swollen tummy that’s not related to when you eat. […] You might find you get used to them. But it’s important to be checked by a GP if your symptoms change, get worse, or do not feel normal for you.

• #24 Signs of Gallbladder Cancer | Symptoms of Gallbladder Cancer | American Cancer Society

  https://www.cancer.org/cancer/types/gallbladder-cancer/detection-diagnosis-staging/signs-and-symptoms.html

  Gallbladder cancer doesn’t usually cause signs or symptoms until later in the course of the disease, when the tumor is large and/or has spread. But sometimes symptoms can appear sooner and lead to an early diagnosis. If the cancer is found at an earlier stage, treatment might work better. […] Some of the more common symptoms of gallbladder cancer include: […] Most people with gallbladder cancer will have belly pain. Most often it’s in the upper right part of the belly. […] Some people with gallbladder cancer sometimes have vomiting as a symptom. […] If the cancer gets big enough to block the bile ducts, bile from the liver cant drain into the intestines. This can cause a greenish-yellow chemical (called bilirubin) in the bile to build up in the blood and settle in different parts of the body. The yellow coloring of jaundice can often be seen in the skin and the white part of the eyes.

• #25 Signs of gallbladder cancer | Ada

  https://ada.com/conditions/gallbladder-cancer/

  Nausea and/or vomiting: This symptom is common in the later stages of gallbladder cancer. […] Yellowing of the skin and whites of the eyes, known as jaundice: This occurs if the tumor grows big enough to block the bile ducts, which normally drain bile from the liver into the intestines. This can lead to a yellowish chemical found in bile, called bilirubin, building up in the blood and settling in different areas of the body. […] Lumps on the right side of the stomach: The gallbladder may swell if the tumor blocks the bile ducts. Gallbladder cancer may also spread to nearby parts of the liver, which may also present as lumps. […] Less common signs of gallbladder cancer may include: Loss of appetite and/or weight, Indigestion, such as bloating and burping, Swollen stomach, Fever, Itchiness, Dark urine, Greasy or light-colored feces. […] These symptoms are much more likely to be caused by other conditions, as gallbladder cancer is rare. For instance, hepatitis is a common cause of jaundice. However, if any of these symptoms are present, it is important to seek medical attention as soon as possible to treat the underlying cause.

• #26 Symptoms of gallbladder cancer | Cancer Research UK

  https://www.cancerresearchuk.org/about-cancer/gallbladder-cancer/symptoms

  Jaundice means either that your liver is not working properly, or that there is a blockage in your biliary system. The symptoms can include: yellowing skin and whites of the eyes, severe itching in some people, darkened urine, pale coloured stools (bowel movements). […] If your bile duct is blocked, your gallbladder will fill up with bile and get swollen and enlarged. […] Less common symptoms include: loss of appetite (anorexia), loss of weight without dieting, a swollen tummy (abdomen). […] Abdominal pain is a sign of many diseases that are far more common than gallbladder cancer. But it is best to be safe. So if you have any of these symptoms, do see your doctor. Most health problems are much easier to treat when they are found early.

• #27 Overview & Symptoms – Gallbladder & Bile Duct Cancer  |  Johns Hopkins Pathology

  https://pathology.jhu.edu/gbbd/overview-and-symptoms

  Patients with bile duct cancer most often become symptomatic when the cancer obstructs (blocks) the drainage of bile. Because bile cannot be excreted into the bowel, the bilirubin pigments accumulate in the blood, causing jaundice in 90% of patients. The jaundice is usually associated with itching of the skin (also called „pruritus”). The body compensates partially and excretes some of this bilirubin via the urine, so patients may have dark (cola colored) urine. Because bile cannot reach the intestine, the patient’s stools become white (clay colored). […] Other symptoms result from inflammation secondary to tumor obstruction. Patients with gallbladder cancer may have pain in the right upper portion of the abdomen. This pain is a result of inflammation of the gallbladder (cholecystitis) due to blockage of the cystic duct. In fact, approximately 1% of patients who undergo cholecystectomy for suspected cholecystitis prove to have unsuspected gallbladder carcinoma. Distal bile duct tumors near the ampulla of Vater, the point at which the bile drains into the bowel, obstruct the pancreatic duct and lead to inflammation of the pancreas (pancreatitis). […] Yellowing of the skin or whites of the eyes caused by the accumulation of bile pigments. (usually due to an obstruction of the bile ducts.)

• #28 Symptoms of gallbladder cancer | Cancer Research UK

  https://www.cancerresearchuk.org/about-cancer/gallbladder-cancer/symptoms

  Jaundice means either that your liver is not working properly, or that there is a blockage in your biliary system. The symptoms can include: yellowing skin and whites of the eyes, severe itching in some people, darkened urine, pale coloured stools (bowel movements). […] If your bile duct is blocked, your gallbladder will fill up with bile and get swollen and enlarged. […] Less common symptoms include: loss of appetite (anorexia), loss of weight without dieting, a swollen tummy (abdomen). […] Abdominal pain is a sign of many diseases that are far more common than gallbladder cancer. But it is best to be safe. So if you have any of these symptoms, do see your doctor. Most health problems are much easier to treat when they are found early.

• #29 Symptoms of gallbladder cancer – NHS

  https://www.nhs.uk/conditions/gallbladder-cancer/symptoms/

  Gallbladder cancer may not have any symptoms, or they might be hard to spot. […] Symptoms of gallbladder cancer include: the whites of your eyes turning yellow or your skin turning yellow, which may be less obvious on brown or black skin (jaundice) you may also have itchy skin, darker pee and paler poo than usual […] loss of appetite or losing weight without trying to […] a high temperature, or you feel hot or shivery […] a lump in your tummy. […] Other symptoms can affect your digestion, such as: feeling or being sick […] aching pain in the right side of your tummy, sometimes described as a „dragging feeling” […] sharp pain in your tummy […] a very swollen tummy that’s not related to when you eat. […] You might find you get used to them. But it’s important to be checked by a GP if your symptoms change, get worse, or do not feel normal for you.

• #30 Symptoms of gallbladder cancer | Cancer Research UK

  https://www.cancerresearchuk.org/about-cancer/gallbladder-cancer/symptoms

  Jaundice means either that your liver is not working properly, or that there is a blockage in your biliary system. The symptoms can include: yellowing skin and whites of the eyes, severe itching in some people, darkened urine, pale coloured stools (bowel movements). […] If your bile duct is blocked, your gallbladder will fill up with bile and get swollen and enlarged. […] Less common symptoms include: loss of appetite (anorexia), loss of weight without dieting, a swollen tummy (abdomen). […] Abdominal pain is a sign of many diseases that are far more common than gallbladder cancer. But it is best to be safe. So if you have any of these symptoms, do see your doctor. Most health problems are much easier to treat when they are found early.

• #31 Gallbladder Cancer Symptoms | Modern Cancer Hospital Guangzhou, China

  https://www.asiancancer.com/en/cancer-symptoms/gallbladder-cancer-symptoms/

  There are few symptoms and no specificity in early gallbladder cancer, but early detection and early treatment are the key to increase survival rate. As mentioned above, active surgery has certain significance for improvement of survival rate. If you suspect yourself for developing gallbladder cancer and you cannot distinguish between normal and abnormal signs, you need to ask for help from doctor as soon as possible. If you are diagnosed with gallbladder cancer, immediate treatment should be done so as to prevent it getting worse. […] Normally gallbladder cancer comes without special clinical symptoms or only develops the symptoms of chronic cholecystitis. The early diagnosis of it is hard that once constant pain, lump, jaundice occur, a patient is already in late stages. […] Symptoms of gallbladder cancer: 1. Symptoms of enteron. Most patients (about 90%) develop dyspepsia, aversion to greasy food, belching, poor appetite and other symptoms because of functional defect of gallbladder, which means the patients cannot digest fatty material. 2. Pain in right upper abdomen. Over 80% gallbladder cancer patients are suffering from cholecystolithiasis at the same time that some similar symptoms of cholecystolithiasis or cholecystitis develop. Most cases would present the pain in right upper abdomen first, which would develop to constant vague or dull pain and occasionally accompanied by the paroxysmal acute pain that can extend to right shoulder. 3. Lump in right upper abdomen. About 50% patients develop the lump in right upper abdomen or upper abdominal regions, among them mostly are enlarged gallbladder. 4. Jaundice and skin itch normally appear in late stage of gallbladder cancer. Obstruction of bile duct resulted by cancer tissues encroaching on bile ducts or swelling metastatic lymph nodes depressing on bile ducts that the bile secreted by liver cannot enter intestines but flows black to blood would lead to yellow satin in skin and mucous membrane. And a patient with jaundice is normally accompanied by the skin itch that is hard to relieve and may aggravates at night. 5. Fever and emaciation. Around 25% patients would present fever, which causes from secondary infection of biliary tract. Cachexia may even develop in late stage patients as well.

• #32 Gallbladder cancer – Symptoms and causes – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/gallbladder-cancer/symptoms-causes/syc-20353370

  Gallbladder cancer may not be found until it’s advanced because it may cause no symptoms. When they happen, the symptoms may be like those of common conditions. […] Gallbladder cancer may have no symptoms. When there are signs and symptoms, they may include: Belly pain, mostly in the upper right part of the belly. Belly bloating. A mass you can feel through the skin. Losing weight without trying. Yellowing of the skin and whites of the eyes, called jaundice. Yellowing of the skin might be harder to see on Black or brown skin. Jaundice typically happens when the gallbladder cancer is very advanced. […] But most gallbladder cancers are found when they’ve grown beyond the gallbladder. Then the chance to survive, called prognosis, often is poor.

• #33 Gallbladder Cancer

  https://pmc.ncbi.nlm.nih.gov/articles/PMC3104187/

  Carcinoma of the gallbladder is notoriously lethal. Complete surgical extirpation is the only effective treatment. Because early symptoms are vague and anatomically the gallbladder lacks a serosa to limit the spreading of cancer, the diagnosis of gallbladder cancer frequently occurs at an advanced stage, typically with an abysmal prognosis. Its 5-year survival rate is less than 5% for more advanced stages. […] A common presentation for early-stage gallbladder cancer mimics cholecystitis with upper abdominal pain similar to biliary colic and the presence of cholelithiasis. […] Late stages present with anorexia, malaise, weight loss, nausea, vomiting, or cholestatic jaundice. These features, particularly jaundice indicating bile duct involvement, carry a dismal prognosis.

• #34 Symptoms of gallbladder cancer | Cancer Research UK

  https://www.cancerresearchuk.org/about-cancer/gallbladder-cancer/symptoms

  Gallbladder cancer doesn’t usually cause symptoms in the early stages. When you do have symptoms, they can include: tummy (abdominal) pain, feeling sick, yellowing of the skin and whites of the eyes (jaundice), an enlarged gallbladder, weight loss. […] Gallbladder cancer is often diagnosed at a more advanced stage than some other types of cancer. At diagnosis, it may have spread outside the gallbladder to areas nearby. […] You may get a number of symptoms with gallbladder cancer. Most of these happen in the later stages of the disease. […] You can get an aching feeling on your right side if you have gallbladder cancer. Some people describe it as a dragging feeling. If the cancer or gallstones block the bile duct, you will have a sharper pain. […] This is very common in the later stages of gallbladder cancer. Over half the people diagnosed with gallbladder cancer will feel or be sick quite often at some stage of their illness.

• #35 Symptoms of gallbladder cancer | Cancer Research UK

  https://www.cancerresearchuk.org/about-cancer/gallbladder-cancer/symptoms

  Gallbladder cancer doesn’t usually cause symptoms in the early stages. When you do have symptoms, they can include: tummy (abdominal) pain, feeling sick, yellowing of the skin and whites of the eyes (jaundice), an enlarged gallbladder, weight loss. […] Gallbladder cancer is often diagnosed at a more advanced stage than some other types of cancer. At diagnosis, it may have spread outside the gallbladder to areas nearby. […] You may get a number of symptoms with gallbladder cancer. Most of these happen in the later stages of the disease. […] You can get an aching feeling on your right side if you have gallbladder cancer. Some people describe it as a dragging feeling. If the cancer or gallstones block the bile duct, you will have a sharper pain. […] This is very common in the later stages of gallbladder cancer. Over half the people diagnosed with gallbladder cancer will feel or be sick quite often at some stage of their illness.

• #36 What Are Gallbladder Cancer Symptoms and Is It Easy to Detect? – Ezra

  https://ezra.com/blog/gallbladder-cancer-symptoms

  Bloating of the abdomen: Swelling or enlargement of the abdomen is often accompanied by discomfort or pain. […] Nausea and vomiting: In cases of bile duct obstruction, bile can’t flow into the intestines as usual. […] Unintended weight loss: Unexplained weight loss over a short period can signal gallbladder cancer or other types of cancers. […] Appetite loss: Loss of appetite is when you dont want to eat or dont experience the same hunger cues despite eating less than usual. […] Itchy skin: When bilirubin and other toxins build up in the skin, it can cause severe itching. […] The early stages of gallbladder cancer are often silent, meaning they do not exhibit noticeable symptoms.

• #37 Gallbladder Cancer Signs, Symptoms and Types | Banner Health

  https://www.bannerhealth.com/services/cancer/cancer-type/gallbladder-cancer/symptoms-and-types

  Gallbladder cancer can be tough to detect early because there arent usually symptoms until its more advanced. Sometimes, its discovered during surgery for gallstones or other reasons. […] However, you may notice these possible signs of gallbladder cancer. These symptoms could be caused by a lot of different health conditions, including gallstones in some cases, but its important to see a health care provider if you notice them: […] Belly pain: Pain in the upper right side of the abdomen that may get worse over time. […] Jaundice: Yellow skin and eyes, caused when the bile duct is blocked by the tumor. Jaundice is a sign that the cancer is advanced. […] Nausea and vomiting: Cancer that blocks the digestive tract may cause these symptoms. […] Losing weight: As cancer progresses, it can cause weight loss.

• #38 Recognize These 6 Warning Signs of Gallbladder Cancer

  https://actchealth.com/blogs/recognize-these-6-warning-signs-of-gallbladder-cancer

  Gallbladder cancer often blocks the bile ducts, causing a buildup of bile, which can lead to loss of appetite and extreme nausea. If left unaddressed, the condition can worsen and eventually lead to vomiting and extreme weight loss. […] These signs and symptoms are not exclusive to gallbladder cancer and may also be present in other conditions. Therefore, it is essential to consult a doctor if any of these symptoms persist or worsen. […] The prognosis for gallbladder cancer depends on the stage at which it is diagnosed. In general, it has a poor prognosis because it is often detected at an advanced stage. However, if it is diagnosed at an early stage, the chances of successful treatment and cure are higher. The 5-year survival rate for localized (confined to the gallbladder) gallbladder cancer is 80%.

• #39 Signs of Gallbladder Cancer | Symptoms of Gallbladder Cancer | American Cancer Society

  https://www.cancer.org/cancer/types/gallbladder-cancer/detection-diagnosis-staging/signs-and-symptoms.html

  If the cancer blocks the bile ducts, the gallbladder can swell. Gallbladder cancer can also spread to nearby parts of the liver. These changes can sometimes be felt by the doctor as lumps on the right side of the belly. They can also be seen on imaging tests such as an ultrasound. […] Less common symptoms of gallbladder cancer include: […] Keep in mind: Gallbladder cancer is rare. These symptoms are more likely to be caused by something other than gallbladder cancer. […] Still, if you have any of these problems, its important to see a doctor right away so the cause can be found and treated, if needed.

• #40 Signs of gallbladder cancer | Ada

  https://ada.com/conditions/gallbladder-cancer/

  Nausea and/or vomiting: This symptom is common in the later stages of gallbladder cancer. […] Yellowing of the skin and whites of the eyes, known as jaundice: This occurs if the tumor grows big enough to block the bile ducts, which normally drain bile from the liver into the intestines. This can lead to a yellowish chemical found in bile, called bilirubin, building up in the blood and settling in different areas of the body. […] Lumps on the right side of the stomach: The gallbladder may swell if the tumor blocks the bile ducts. Gallbladder cancer may also spread to nearby parts of the liver, which may also present as lumps. […] Less common signs of gallbladder cancer may include: Loss of appetite and/or weight, Indigestion, such as bloating and burping, Swollen stomach, Fever, Itchiness, Dark urine, Greasy or light-colored feces. […] These symptoms are much more likely to be caused by other conditions, as gallbladder cancer is rare. For instance, hepatitis is a common cause of jaundice. However, if any of these symptoms are present, it is important to seek medical attention as soon as possible to treat the underlying cause.

• #41 Signs of Gallbladder Cancer | Symptoms of Gallbladder Cancer | American Cancer Society

  https://www.cancer.org/cancer/types/gallbladder-cancer/detection-diagnosis-staging/signs-and-symptoms.html

  If the cancer blocks the bile ducts, the gallbladder can swell. Gallbladder cancer can also spread to nearby parts of the liver. These changes can sometimes be felt by the doctor as lumps on the right side of the belly. They can also be seen on imaging tests such as an ultrasound. […] Less common symptoms of gallbladder cancer include: […] Keep in mind: Gallbladder cancer is rare. These symptoms are more likely to be caused by something other than gallbladder cancer. […] Still, if you have any of these problems, its important to see a doctor right away so the cause can be found and treated, if needed.

• #42 Gallbladder Cancer Signs & Symptoms | Memorial Sloan Kettering Cancer Center

  https://www.mskcc.org/cancer-care/types/gallbladder-cancer/gallbladder-cancer-signs-symptoms

  Gallbladder cancer may make it uncomfortable to eat or make you feel like you dont want to eat at all. […] The pain or bloating typically occurs in the upper right part of the belly. […] Fatigue is a common symptom of many types of cancer, including gallbladder cancer. […] Gallbladder cancer that blocks the bile ducts or has spread to the liver can sometimes be felt by doctors on the right side of the belly.

• #43 Symptoms of gallbladder cancer – NHS

  https://www.nhs.uk/conditions/gallbladder-cancer/symptoms/

  Gallbladder cancer may not have any symptoms, or they might be hard to spot. […] Symptoms of gallbladder cancer include: the whites of your eyes turning yellow or your skin turning yellow, which may be less obvious on brown or black skin (jaundice) you may also have itchy skin, darker pee and paler poo than usual […] loss of appetite or losing weight without trying to […] a high temperature, or you feel hot or shivery […] a lump in your tummy. […] Other symptoms can affect your digestion, such as: feeling or being sick […] aching pain in the right side of your tummy, sometimes described as a „dragging feeling” […] sharp pain in your tummy […] a very swollen tummy that’s not related to when you eat. […] You might find you get used to them. But it’s important to be checked by a GP if your symptoms change, get worse, or do not feel normal for you.

• #44 Gallbladder cancer – Symptoms and causes – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/gallbladder-cancer/symptoms-causes/syc-20353370

  Gallbladder cancer may not be found until it’s advanced because it may cause no symptoms. When they happen, the symptoms may be like those of common conditions. […] Gallbladder cancer may have no symptoms. When there are signs and symptoms, they may include: Belly pain, mostly in the upper right part of the belly. Belly bloating. A mass you can feel through the skin. Losing weight without trying. Yellowing of the skin and whites of the eyes, called jaundice. Yellowing of the skin might be harder to see on Black or brown skin. Jaundice typically happens when the gallbladder cancer is very advanced. […] But most gallbladder cancers are found when they’ve grown beyond the gallbladder. Then the chance to survive, called prognosis, often is poor.

• #45 Gallbladder Cancer Signs & Symptoms | Memorial Sloan Kettering Cancer Center

  https://www.mskcc.org/cancer-care/types/gallbladder-cancer/gallbladder-cancer-signs-symptoms

  Gallbladder cancer doesnt usually cause many symptoms until it reaches an advanced stage, when it has spread to other organs and tissues. […] Occasionally, symptoms appear at an early stage, when treatment is more effective. […] Common signs and symptoms of gallbladder cancer include: Jaundice, Weight Loss, Fever, Loss of Appetite, Bloating or Pain in the Belly, Fatigue, Lumps in the Belly. […] Jaundice is a condition in which the skin and the whites of the eyes become yellow, urine darkens, and the color of stool is lighter than normal. This can occur because a gallbladder tumor has grown large enough to block the bile duct. […] The loss of a significant amount of weight without trying can be a sign of many cancers, including gallbladder cancer. […] An increase in body temperature without another explanation can be an early sign of cancer, including gallbladder cancer.

• #46 Gallbladder Cancer Symptoms Don’t Appear Early On

  https://www.verywellhealth.com/gallbladder-cancer-symptoms-514049

  Unfortunately, from a diagnosis standpoint, gallbladder cancer does not often have symptoms in the early, most curable stages of the disease. Many of the signs and symptoms of gallbladder cancer occur when the tumor is already in the advanced stages or when it has spread to nearby organs. […] When present, symptoms of gallbladder cancer may include: […] Abdominal pain: It is estimated that about 50% of people with gallbladder cancer experience abdominal pain as a symptom. This abdominal pain is felt most commonly in the upper right abdomen. […] Loss of appetite: A general loss of appetite often accompanies a diagnosis of gallbladder cancer. […] Vomiting: Vomiting and a general feeling of nausea are fairly common symptoms of gallbladder cancer. […] Weight loss: Unexplained or unintentional weight loss may be the first symptom of gallbladder cancer. Unintentional weight loss is a sign of underlying cancer roughly a third of the time, and of cancers, abdominal cancers such as gallbladder cancer are responsible for around half of these. One study found that 40% of people newly diagnosed with gallbladder cancer had experienced unintentional weight loss.

• #47 Symptoms of gallbladder cancer | Cancer Research UK

  https://www.cancerresearchuk.org/about-cancer/gallbladder-cancer/symptoms

  Jaundice means either that your liver is not working properly, or that there is a blockage in your biliary system. The symptoms can include: yellowing skin and whites of the eyes, severe itching in some people, darkened urine, pale coloured stools (bowel movements). […] If your bile duct is blocked, your gallbladder will fill up with bile and get swollen and enlarged. […] Less common symptoms include: loss of appetite (anorexia), loss of weight without dieting, a swollen tummy (abdomen). […] Abdominal pain is a sign of many diseases that are far more common than gallbladder cancer. But it is best to be safe. So if you have any of these symptoms, do see your doctor. Most health problems are much easier to treat when they are found early.

• #48 What Are Gallbladder Cancer Symptoms and Is It Easy to Detect? – Ezra

  https://ezra.com/blog/gallbladder-cancer-symptoms

  Bloating of the abdomen: Swelling or enlargement of the abdomen is often accompanied by discomfort or pain. […] Nausea and vomiting: In cases of bile duct obstruction, bile can’t flow into the intestines as usual. […] Unintended weight loss: Unexplained weight loss over a short period can signal gallbladder cancer or other types of cancers. […] Appetite loss: Loss of appetite is when you dont want to eat or dont experience the same hunger cues despite eating less than usual. […] Itchy skin: When bilirubin and other toxins build up in the skin, it can cause severe itching. […] The early stages of gallbladder cancer are often silent, meaning they do not exhibit noticeable symptoms.

• #49 Gallbladder Cancer – Symptoms, Support and Treatments | UC Health

  https://www.uchealth.com/en/conditions/gallbladder-cancer

  Gallbladder cancer is an uncommon type of cancer that starts in the cells of the gallbladder. This cancer can sometimes be difficult to diagnose because there are often no symptoms. […] The symptoms of gallbladder cancer usually don’t occur until the tumor is big or the cancer has spread. The symptoms of gallbladder cancer may include: […] You can have gallbladder cancer with no symptoms. […] Pain or discomfort in the right side of the upper abdomen (belly). […] Lumps in the abdomen. […] A sense of fullness after eating even small amounts. […] Nausea and vomiting. […] Poor appetite. […] Loss of weight without trying. […] Fever. […] Yellowing of the skin or the white part of the eyes (jaundice). […] Severe itching. […] Many of these may be caused by other health problems. It is important to see a healthcare provider if you have these symptoms. Only a healthcare provider can tell if you have cancer.

• #50 Gallbladder Cancer Symptoms, Diagnosis & Treatment | UPMC

  https://www.upmc.com/services/liver-cancer/conditions/gallbladder-cancer

  Many people who have gallbladder cancer have nonspecific symptoms. […] Other symptoms, sometimes associated with gallbladder tumors include: Abdominal cramping, Intolerance of fatty foods, Pain in the right upper abdomen, New onset jaundice (yellowish coloring of the skin that results from excess bile).

• #51 Gallbladder Cancer Signs & Symptoms | Memorial Sloan Kettering Cancer Center

  https://www.mskcc.org/cancer-care/types/gallbladder-cancer/gallbladder-cancer-signs-symptoms

  Gallbladder cancer doesnt usually cause many symptoms until it reaches an advanced stage, when it has spread to other organs and tissues. […] Occasionally, symptoms appear at an early stage, when treatment is more effective. […] Common signs and symptoms of gallbladder cancer include: Jaundice, Weight Loss, Fever, Loss of Appetite, Bloating or Pain in the Belly, Fatigue, Lumps in the Belly. […] Jaundice is a condition in which the skin and the whites of the eyes become yellow, urine darkens, and the color of stool is lighter than normal. This can occur because a gallbladder tumor has grown large enough to block the bile duct. […] The loss of a significant amount of weight without trying can be a sign of many cancers, including gallbladder cancer. […] An increase in body temperature without another explanation can be an early sign of cancer, including gallbladder cancer.

• #52 Gallbladder Cancer Symptoms | Modern Cancer Hospital Guangzhou, China

  https://www.asiancancer.com/en/cancer-symptoms/gallbladder-cancer-symptoms/

  There are few symptoms and no specificity in early gallbladder cancer, but early detection and early treatment are the key to increase survival rate. As mentioned above, active surgery has certain significance for improvement of survival rate. If you suspect yourself for developing gallbladder cancer and you cannot distinguish between normal and abnormal signs, you need to ask for help from doctor as soon as possible. If you are diagnosed with gallbladder cancer, immediate treatment should be done so as to prevent it getting worse. […] Normally gallbladder cancer comes without special clinical symptoms or only develops the symptoms of chronic cholecystitis. The early diagnosis of it is hard that once constant pain, lump, jaundice occur, a patient is already in late stages. […] Symptoms of gallbladder cancer: 1. Symptoms of enteron. Most patients (about 90%) develop dyspepsia, aversion to greasy food, belching, poor appetite and other symptoms because of functional defect of gallbladder, which means the patients cannot digest fatty material. 2. Pain in right upper abdomen. Over 80% gallbladder cancer patients are suffering from cholecystolithiasis at the same time that some similar symptoms of cholecystolithiasis or cholecystitis develop. Most cases would present the pain in right upper abdomen first, which would develop to constant vague or dull pain and occasionally accompanied by the paroxysmal acute pain that can extend to right shoulder. 3. Lump in right upper abdomen. About 50% patients develop the lump in right upper abdomen or upper abdominal regions, among them mostly are enlarged gallbladder. 4. Jaundice and skin itch normally appear in late stage of gallbladder cancer. Obstruction of bile duct resulted by cancer tissues encroaching on bile ducts or swelling metastatic lymph nodes depressing on bile ducts that the bile secreted by liver cannot enter intestines but flows black to blood would lead to yellow satin in skin and mucous membrane. And a patient with jaundice is normally accompanied by the skin itch that is hard to relieve and may aggravates at night. 5. Fever and emaciation. Around 25% patients would present fever, which causes from secondary infection of biliary tract. Cachexia may even develop in late stage patients as well.

• #53 Symptoms of gallbladder cancer – NHS

  https://www.nhs.uk/conditions/gallbladder-cancer/symptoms/

  Gallbladder cancer may not have any symptoms, or they might be hard to spot. […] Symptoms of gallbladder cancer include: the whites of your eyes turning yellow or your skin turning yellow, which may be less obvious on brown or black skin (jaundice) you may also have itchy skin, darker pee and paler poo than usual […] loss of appetite or losing weight without trying to […] a high temperature, or you feel hot or shivery […] a lump in your tummy. […] Other symptoms can affect your digestion, such as: feeling or being sick […] aching pain in the right side of your tummy, sometimes described as a „dragging feeling” […] sharp pain in your tummy […] a very swollen tummy that’s not related to when you eat. […] You might find you get used to them. But it’s important to be checked by a GP if your symptoms change, get worse, or do not feel normal for you.

• #54 Gallbladder cancer – Symptoms and causes – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/gallbladder-cancer/symptoms-causes/syc-20353370

  Gallbladder cancer may not be found until it’s advanced because it may cause no symptoms. When they happen, the symptoms may be like those of common conditions. […] Gallbladder cancer may have no symptoms. When there are signs and symptoms, they may include: Belly pain, mostly in the upper right part of the belly. Belly bloating. A mass you can feel through the skin. Losing weight without trying. Yellowing of the skin and whites of the eyes, called jaundice. Yellowing of the skin might be harder to see on Black or brown skin. Jaundice typically happens when the gallbladder cancer is very advanced. […] But most gallbladder cancers are found when they’ve grown beyond the gallbladder. Then the chance to survive, called prognosis, often is poor.

• #55 Gallbladder Cancer Signs & Symptoms | Memorial Sloan Kettering Cancer Center

  https://www.mskcc.org/cancer-care/types/gallbladder-cancer/gallbladder-cancer-signs-symptoms

  Gallbladder cancer may make it uncomfortable to eat or make you feel like you dont want to eat at all. […] The pain or bloating typically occurs in the upper right part of the belly. […] Fatigue is a common symptom of many types of cancer, including gallbladder cancer. […] Gallbladder cancer that blocks the bile ducts or has spread to the liver can sometimes be felt by doctors on the right side of the belly.

• #56 Gallbladder Cancer Symptoms: Male vs. Female Signs & Early Detection

  https://www.blkmaxhospital.com/blogs/gallbladder-cancer-symptoms-men-women

  One of the more advanced-stage gallbladder cancer symptoms is a loss of appetite. This may be accompanied by weight loss and a general feeling of fatigue. […] If you are experiencing weakness, it may be a symptom of advanced-stage gallbladder cancer. […] Losing weight without trying is one of the most common and earliest symptoms of gallbladder cancer. […] Gallbladder cancer affects men and women differently due to variations in hormones and bile metabolism. While the general symptoms remain the same, men may experience: […] Women are at a higher risk of developing gallbladder cancer due to hormonal influences and a higher prevalence of gallstones. Symptoms unique to females include: […] Seek medical attention if you experience persistent upper abdominal pain, unexplained jaundice, or unexplained weight loss. Early detection through imaging tests like ultrasound, CT scans, or MRIs can improve treatment outcomes.

• #57 Recognize These 6 Warning Signs of Gallbladder Cancer

  https://actchealth.com/blogs/recognize-these-6-warning-signs-of-gallbladder-cancer

  It is a condition where the skin and the eyes turn yellow due to excessive buildup of bilirubin, a substance produced by the liver. This disease often causes jaundice when the tumor blocks the bile ducts. It may also produce symptoms like pale stools and dark urine. […] If cancer has spread to the liver or other organs in the abdomen, it can cause abdominal swelling. Swelling can also lead to a feeling of fullness or discomfort in the abdomen. […] Although it is a less common symptom, blood clots may occur in some cases. Over time, small red patches can be seen in the skin over the abdominal area due to blood clots. […] High body temperature along with severe abdominal or back pain can be a result of gallbladder cancer. If the fever is persistent and followed by chills, it is crucial to consult a primary care physician immediately.

• #58 Signs of gallbladder cancer | Ada

  https://ada.com/conditions/gallbladder-cancer/

  Nausea and/or vomiting: This symptom is common in the later stages of gallbladder cancer. […] Yellowing of the skin and whites of the eyes, known as jaundice: This occurs if the tumor grows big enough to block the bile ducts, which normally drain bile from the liver into the intestines. This can lead to a yellowish chemical found in bile, called bilirubin, building up in the blood and settling in different areas of the body. […] Lumps on the right side of the stomach: The gallbladder may swell if the tumor blocks the bile ducts. Gallbladder cancer may also spread to nearby parts of the liver, which may also present as lumps. […] Less common signs of gallbladder cancer may include: Loss of appetite and/or weight, Indigestion, such as bloating and burping, Swollen stomach, Fever, Itchiness, Dark urine, Greasy or light-colored feces. […] These symptoms are much more likely to be caused by other conditions, as gallbladder cancer is rare. For instance, hepatitis is a common cause of jaundice. However, if any of these symptoms are present, it is important to seek medical attention as soon as possible to treat the underlying cause.

• #59 Gallbladder Cancer Symptoms: Male vs. Female Signs & Early Detection

  https://www.blkmaxhospital.com/blogs/gallbladder-cancer-symptoms-men-women

  One of the most common symptoms is nausea. This can be caused by the tumor itself or by the treatments used to fight cancer. Bile and vomiting are also common symptoms. […] If you’re experiencing indigestion along with other symptoms like pain in your abdomen or back, it could be a sign of advanced-stage gallbladder cancer. […] One of the more advanced-stage gallbladder cancer symptoms is bloating. This may be caused by the tumor pressing on the intestines or by a build-up of fluid in the abdomen. […] One of the more advanced-stage symptoms of gallbladder cancer may be a lump in the abdomen. This is often one of the first signs that something is wrong, and it can be quite alarming. […] If you have a fever and are experiencing other symptoms of gallbladder cancer, it is important to see a doctor right away.

• #60 Gallbladder cancer – Rakic – Hepatobiliary Surgery and Nutrition

  https://hbsn.amegroups.org/article/view/4726/html

  Gallbladder cancer is the fifth most common cancer involving gastrointestinal tract, but it is the most common malignancy of the biliary tract, accounting for 80-95% of biliary tract cancers. […] An early diagnosis is essential as this malignancy progresses silently with a late diagnosis. […] In most instances, gallbladder cancer develops over 5 to 15 years, when metaplasia progresses to dysplasia, carcinoma in situ, and then, invasive cancer. […] A satisfactory outcome depends on an early diagnosis and surgical resection. […] This tumour is traditionally regarded as a highly lethal disease with an overall 5-year survival of less than 5%. […] The overall mean survival rate for patients with gallbladder cancer is 6 months. […] Clinical presentation is similar to biliary colic or chronic cholecystitis. The most common symptoms are: persistent right upper quadrant pain, jaundice, nausea and weight loss.

• #61 Gallbladder cancer – Diagnosis and treatment – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/gallbladder-cancer/diagnosis-treatment/drc-20353374

  Gallbladder cancer diagnosis might start with a discussion about your symptoms. A healthcare professional might use blood tests to understand how your organs are working and imaging tests to look for signs of cancer in the gallbladder. […] Once your healthcare professional diagnoses your gallbladder cancer, the next step is to find the extent of the cancer. This is called staging. Your gallbladder cancer’s stage helps show your prognosis and helps with treatment choices. […] A stage 1 gallbladder cancer means the cancer is only in the gallbladder. As the cancer grows larger and grows beyond the gallbladder, the stages go up. A stage 4 gallbladder cancer means the cancer has grown through the gallbladder and into nearby organs. Stage 4 also may mean the cancer has spread to other parts of the body.

• #62

  http://www.bccancer.bc.ca/health-info/types-of-cancer/digestive-system/gallbladder

  Gallbladder cancer staging: Stage 0: Tumour (cancer growth) is only in the inner lining of the gallbladder. It has not grown into the gallbladder wall. Stage 1A: Tumour has grown into the connective tissue layer (lamina propria) of the gallbladder. Stage 1B: Tumour has grown into the muscle layer around the lamina propria. Stage 2A: Tumour has grown into the connective tissue on top of the muscle layer on the side of the gallbladder that is next to the liver. Stage 2B: Tumour has grown into the perimuscular connective tissue on the side of the gallbladder next to the peritoneum (a layer of tissue that lines your abdominal cavity). Stage 3A: One of the following: Tumour has grown through the outer layer of the gallbladder (serosa) Tumour has grown into the liver. Tumour has grown into 1 nearby organ. Stage 3B: Tumour has grown through the outer layer of the gallbladder or into the gallbladder wall AND has spread to 1-3 nearby lymph nodes. Stage 4: Cancer has spread to any of the following areas: Main blood vessels leading into the liver (portal vein or hepatic artery), with or without spreading to 1-3 lymph nodes. Two or more organs outside the gallbladder, with or without spreading to 1-3 lymph nodes. 4 or more nearby lymph nodes. Parts of the body farther away from the gallbladder, such as the lungs. This is called distant metastasis.

• #63 Gallbladder cancer – Diagnosis and treatment – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/gallbladder-cancer/diagnosis-treatment/drc-20353374

  Gallbladder cancer diagnosis might start with a discussion about your symptoms. A healthcare professional might use blood tests to understand how your organs are working and imaging tests to look for signs of cancer in the gallbladder. […] Once your healthcare professional diagnoses your gallbladder cancer, the next step is to find the extent of the cancer. This is called staging. Your gallbladder cancer’s stage helps show your prognosis and helps with treatment choices. […] A stage 1 gallbladder cancer means the cancer is only in the gallbladder. As the cancer grows larger and grows beyond the gallbladder, the stages go up. A stage 4 gallbladder cancer means the cancer has grown through the gallbladder and into nearby organs. Stage 4 also may mean the cancer has spread to other parts of the body.

• #64 Gallbladder Cancer | Huntsman Cancer Institute | University of Utah Health

  https://healthcare.utah.edu/huntsmancancerinstitute/gi-cancer/gallbladder-cancer

  These are signs of gallbladder cancer: Yellowing of the skin and whites of the eyes, also called jaundice […] Pain above the stomach […] Fever […] Nausea and vomiting […] Bloating […] Lumps in the abdomen. Many other health problems can also cause these signs. If you have any of these signs, see your doctor as soon as possible. […] Stages of cancer show whether cancer has spread within the gallbladder or to other parts of the body. Cancer spreads in the body in three ways: through tissue, the lymph system, or the blood. […] For gallbladder cancer, your health care team might discuss the disease in terms of how they will recommend treating it. They may call it resectable cancer, which means that it can be removed with surgery. Unresectable cancer cannot be removed with surgery.

• #65 Gallbladder Cancer | Huntsman Cancer Institute | University of Utah Health

  https://healthcare.utah.edu/huntsmancancerinstitute/gi-cancer/gallbladder-cancer

  These are signs of gallbladder cancer: Yellowing of the skin and whites of the eyes, also called jaundice […] Pain above the stomach […] Fever […] Nausea and vomiting […] Bloating […] Lumps in the abdomen. Many other health problems can also cause these signs. If you have any of these signs, see your doctor as soon as possible. […] Stages of cancer show whether cancer has spread within the gallbladder or to other parts of the body. Cancer spreads in the body in three ways: through tissue, the lymph system, or the blood. […] For gallbladder cancer, your health care team might discuss the disease in terms of how they will recommend treating it. They may call it resectable cancer, which means that it can be removed with surgery. Unresectable cancer cannot be removed with surgery.

• #66 Gallbladder Cancer: Practice Essentials, Background, Pathophysiology

  https://emedicine.medscape.com/article/278641-overview

  In its early stages, gallbladder cancer is often asymptomatic. When signs and symptoms do develop, they often overlap with those of gallstones (cholelithiasis) and biliary colic (cholecystitis). Signs and symptoms may become present during the later stages of the disease and may include the following: […] Jaundice, anorexia, and weight loss often indicate more advanced disease. […] At diagnosis, the gallbladder is often replaced or destroyed by the cancer. In addition, approximately 50% of patients have regional lymph node metastases. […] Most patients have regional disease or distant metastases at presentation. Therefore, the prognosis in gallbladder disease is poor, with 5-year survival rates of 15-20%. […] Unfortunately, only about 10-20% of patients present with tumor confined to the gallbladder wall. At diagnosis, 40-60% of patients have lesions that perforate the gallbladder wall and invade adjacent organs (T3) and 45% of patients have regional lymph node involvement (N1). Approximately 30% of patients present with metastatic disease.

• #67 Gallbladder cancer – Wikipedia

  https://en.wikipedia.org/wiki/Gallbladder_cancer

  Abdominal pain, Bloating, Fever, Unexplained weight loss, Nausea, Yellowing of the skin, although some people may have no symptoms […] Most often it is found after symptoms such as abdominal pain, jaundice and vomiting occur, and it has spread to other organs such as the liver. […] Early symptoms mimic gallbladder inflammation due to gallstones. Later, the symptoms may be that of biliary and stomach obstruction. […] The prognosis still remains poor. The cancer commonly spreads to the liver, bile duct, stomach, and duodenum.

• #68 10 Advance Stage Symptoms of Gallbladder Cancer

  https://www.oncoplus.co.in/10-advance-stage-symptoms-of-gallbladder-cancer-you-must-know/

  As the cancer progresses, it can cause a loss of appetite and weight loss. […] Cancer can cause fatigue, a feeling of exhaustion and weakness that is not relieved by rest. […] Cancer-related jaundice can cause itching all over the body. […] As the cancer grows, it can cause abdominal swelling due to the build-up of fluid in the abdomen. […] Gallbladder cancer can cause blood clots, which can be life-threatening if they travel to the lungs. […] The cancer can also cause a bowel obstruction, which can cause constipation, abdominal pain and vomiting. […] Advanced-stage gallbladder cancer can also spread to other parts of the body, such as the liver, lungs, bones and brain. This can cause symptoms such as bone pain, headaches and difficulty breathing. […] In conclusion, Gallbladder cancer is a rare but serious disease that can cause a variety of symptoms as it progresses. The most common symptoms of advanced-stage gallbladder cancer are abdominal pain, jaundice, nausea, vomiting, loss of appetite, fatigue, itching, abdominal swelling, blood clots, bowel obstruction, and metastasis. Its essential to be aware of these symptoms and to see a doctor if you are experiencing any of them. Early diagnosis and treatment can improve the prognosis of gallbladder cancer.

• #69 How Quickly Does Gallbladder Cancer Spread?- SSO Hospital

  https://ssohospitals.com/blogs/how-quickly-does-gallbladder-cancer-spread/

  However, in other instances, it can be aggressive and fast-spreading, with the potential to metastasize rapidly within weeks or a few months. […] Early detection and treatment of gallbladder cancer are crucial for improving patient outcomes, as the disease is often asymptomatic in its initial stages. […] Although gallbladder cancer may not cause noticeable symptoms in its early stages, some possible signs include abdominal pain, nausea, vomiting, jaundice (yellowing of the skin and eyes), unexplained weight loss, and fever. […] Gallbladder cancer can spread quickly, with the rate of metastasis influenced by various factors such as tumor size and location, histological grade, lymphatic and vascular invasion, genetic mutations, immune system status, coexisting medical conditions, and lifestyle choices. […] Early detection and treatment remain essential for improving patient outcomes. Therefore it is important to be aware of the risk factors associated with gallbladder cancer and to recognize the potential symptoms.

• #70

  http://www.bccancer.bc.ca/health-info/types-of-cancer/digestive-system/gallbladder

  The grade of the cancer describes how different the cancer cells look from normal cells and how fast the cancer cells are growing. A pathologist will give the cancer a grade after looking at the cells under a microscope. Gallbladder cancer can be grade 1, 2, or 3. The lower the number, the lower the grade. Low grade: cells are abnormal but look a lot like normal cells. Low grade cancers usually grow slowly and are less likely to spread. High grade: cells are abnormal and do not look like normal cells. High grade cancers usually grow more quickly and are more likely to spread.

• #71 Gallbladder Carcinoma – StatPearls – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK442002/

  Gallbladder carcinoma is a rare malignancy but constitutes nearly half of all biliary tract cancers. […] Early symptoms may be similar to biliary colic or cholecystitis and might account for the late stage of diagnosis associated with this cancer. Consequently, tumors are often nonresectable at diagnosis. […] Advanced stages of gallbladder cancer can cause vague symptoms such as abdominal pain, nausea, weakness, anorexia, loss of appetite, weight loss, and jaundice. More severe cases may lead to biliary obstruction or fistulization to the biliary tree or the duodenum, which are signs of advanced disease. […] The prognosis for gallbladder cancer is generally poor, with a 5-year overall survival of less than 20%. Unfortunately, most cases are diagnosed when unresectable. According to the American Cancer Society statistics, the 5-year survival for localized disease is 69%, for regional metastatic disease is 28%, and for distant metastatic disease, 3%. T1a tumors that are entirely resected have a nearly 100% 5-year survival.

• #72 Gallbladder Cancer: Symptoms, Treatment & Prognosis

  https://my.clevelandclinic.org/health/diseases/17013-gallbladder-cancer

  Gallbladder cancer is a rare form of cancer that often doesnt cause signs or symptoms in the early stages. […] Gallbladder cancer begins in the innermost layer of your gallbladder, called the mucosal layer, and spreads outward. It often doesnt cause signs or symptoms in the early stages. Instead, healthcare providers often find the cancer by chance after gallbladder surgery. […] When symptoms appear, theyre similar to more common conditions, like gallstones or a blockage in a bile duct. […] Symptoms include: Upper abdominal pain. Yellowed skin and yellowed whites of your eyes (jaundice). Lumps in your abdomen. Unexplained weight loss. Nausea and vomiting. Bloating. Fever. […] The prognosis for gallbladder cancer tends to be poor because its not usually diagnosed until its advanced. Only about 20% of gallbladder cancers are diagnosed in the early stages. The five-year survival rate for people with metastasized gallbladder cancer is 2%. The survival rate for localized gallbladder cancer is much higher, at 66%.

• #73 Gallbladder Carcinoma – StatPearls – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK442002/

  Gallbladder carcinoma is a rare malignancy but constitutes nearly half of all biliary tract cancers. […] Early symptoms may be similar to biliary colic or cholecystitis and might account for the late stage of diagnosis associated with this cancer. Consequently, tumors are often nonresectable at diagnosis. […] Advanced stages of gallbladder cancer can cause vague symptoms such as abdominal pain, nausea, weakness, anorexia, loss of appetite, weight loss, and jaundice. More severe cases may lead to biliary obstruction or fistulization to the biliary tree or the duodenum, which are signs of advanced disease. […] The prognosis for gallbladder cancer is generally poor, with a 5-year overall survival of less than 20%. Unfortunately, most cases are diagnosed when unresectable. According to the American Cancer Society statistics, the 5-year survival for localized disease is 69%, for regional metastatic disease is 28%, and for distant metastatic disease, 3%. T1a tumors that are entirely resected have a nearly 100% 5-year survival.

• #74 Recognize These 6 Warning Signs of Gallbladder Cancer

  https://actchealth.com/blogs/recognize-these-6-warning-signs-of-gallbladder-cancer

  Gallbladder cancer often blocks the bile ducts, causing a buildup of bile, which can lead to loss of appetite and extreme nausea. If left unaddressed, the condition can worsen and eventually lead to vomiting and extreme weight loss. […] These signs and symptoms are not exclusive to gallbladder cancer and may also be present in other conditions. Therefore, it is essential to consult a doctor if any of these symptoms persist or worsen. […] The prognosis for gallbladder cancer depends on the stage at which it is diagnosed. In general, it has a poor prognosis because it is often detected at an advanced stage. However, if it is diagnosed at an early stage, the chances of successful treatment and cure are higher. The 5-year survival rate for localized (confined to the gallbladder) gallbladder cancer is 80%.

• #75 Gallbladder Carcinoma – StatPearls – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK442002/

  Gallbladder carcinoma is a rare malignancy but constitutes nearly half of all biliary tract cancers. […] Early symptoms may be similar to biliary colic or cholecystitis and might account for the late stage of diagnosis associated with this cancer. Consequently, tumors are often nonresectable at diagnosis. […] Advanced stages of gallbladder cancer can cause vague symptoms such as abdominal pain, nausea, weakness, anorexia, loss of appetite, weight loss, and jaundice. More severe cases may lead to biliary obstruction or fistulization to the biliary tree or the duodenum, which are signs of advanced disease. […] The prognosis for gallbladder cancer is generally poor, with a 5-year overall survival of less than 20%. Unfortunately, most cases are diagnosed when unresectable. According to the American Cancer Society statistics, the 5-year survival for localized disease is 69%, for regional metastatic disease is 28%, and for distant metastatic disease, 3%. T1a tumors that are entirely resected have a nearly 100% 5-year survival.

• #76 Gallbladder Cancer: Symptoms, Treatment & Prognosis

  https://my.clevelandclinic.org/health/diseases/17013-gallbladder-cancer

  Gallbladder cancer is a rare form of cancer that often doesnt cause signs or symptoms in the early stages. […] Gallbladder cancer begins in the innermost layer of your gallbladder, called the mucosal layer, and spreads outward. It often doesnt cause signs or symptoms in the early stages. Instead, healthcare providers often find the cancer by chance after gallbladder surgery. […] When symptoms appear, theyre similar to more common conditions, like gallstones or a blockage in a bile duct. […] Symptoms include: Upper abdominal pain. Yellowed skin and yellowed whites of your eyes (jaundice). Lumps in your abdomen. Unexplained weight loss. Nausea and vomiting. Bloating. Fever. […] The prognosis for gallbladder cancer tends to be poor because its not usually diagnosed until its advanced. Only about 20% of gallbladder cancers are diagnosed in the early stages. The five-year survival rate for people with metastasized gallbladder cancer is 2%. The survival rate for localized gallbladder cancer is much higher, at 66%.

• #77 Gallbladder Carcinoma – StatPearls – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK442002/

  Gallbladder carcinoma is a rare malignancy but constitutes nearly half of all biliary tract cancers. […] Early symptoms may be similar to biliary colic or cholecystitis and might account for the late stage of diagnosis associated with this cancer. Consequently, tumors are often nonresectable at diagnosis. […] Advanced stages of gallbladder cancer can cause vague symptoms such as abdominal pain, nausea, weakness, anorexia, loss of appetite, weight loss, and jaundice. More severe cases may lead to biliary obstruction or fistulization to the biliary tree or the duodenum, which are signs of advanced disease. […] The prognosis for gallbladder cancer is generally poor, with a 5-year overall survival of less than 20%. Unfortunately, most cases are diagnosed when unresectable. According to the American Cancer Society statistics, the 5-year survival for localized disease is 69%, for regional metastatic disease is 28%, and for distant metastatic disease, 3%. T1a tumors that are entirely resected have a nearly 100% 5-year survival.

• #78 End Stage Gallbladder Cancer: Symptoms, Treatment, Outlook

  https://www.healthline.com/health/cancer/end-stage-gallbladder-cancer-symptoms

  End stage gallbladder cancer is also called stage 4 gallbladder cancer. Symptoms include jaundice, abdominal pain, nausea, and fever. […] Gallbladder cancer often doesn’t cause symptoms in the early stages, which often delays its diagnosis. Only 1 out of 5 gallbladder cancers are discovered in an early stage. Most aren’t found until they’re in an advanced stage. […] Signs and symptoms of gallbladder cancer can include: jaundice, abdominal pain, usually in the upper right part of your abdomen, fever, nausea and vomiting, bloating, a lump or swelling in your abdomen, unintentional weight loss, loss of appetite, itchy skin, dark urine, pale stools. […] End stage gallbladder cancer tends to have a poor outlook, especially if it’s spread to other organs at the time it was diagnosed. […] People with advanced gallbladder cancer have a 5-year relative survival rate of about 3%, according to the ACS.

• #79 Gallbladder Carcinoma – StatPearls – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK442002/

  Gallbladder carcinoma is a rare malignancy but constitutes nearly half of all biliary tract cancers. […] Early symptoms may be similar to biliary colic or cholecystitis and might account for the late stage of diagnosis associated with this cancer. Consequently, tumors are often nonresectable at diagnosis. […] Advanced stages of gallbladder cancer can cause vague symptoms such as abdominal pain, nausea, weakness, anorexia, loss of appetite, weight loss, and jaundice. More severe cases may lead to biliary obstruction or fistulization to the biliary tree or the duodenum, which are signs of advanced disease. […] The prognosis for gallbladder cancer is generally poor, with a 5-year overall survival of less than 20%. Unfortunately, most cases are diagnosed when unresectable. According to the American Cancer Society statistics, the 5-year survival for localized disease is 69%, for regional metastatic disease is 28%, and for distant metastatic disease, 3%. T1a tumors that are entirely resected have a nearly 100% 5-year survival.

• #80 How quickly can gallbladder cancer spread? | Roswell Park Comprehensive Cancer Center – Buffalo, NY

  https://www.roswellpark.org/cancertalk/202203/how-quickly-can-gallbladder-cancer-spread

  Gallbladder cancer is a rare and aggressive disease that is often found incidentally because there are no screening tests for gallbladder cancer like there are for some other cancers, which makes it harder to find the disease at an early stage. […] The majority of people with early disease have no symptoms or will present with nonspecific symptoms like abdominal pain, nausea, vomiting or loss of appetite that resemble gallstone disease or cholecystitis, said Sylvia Alarcon, MD, a former medical oncologist specializing in gastrointestinal cancers at Roswell Park Comprehensive Cancer Center. […] Patients are often diagnosed incidentally with gallbladder cancer during or after surgery to remove the gallbladder due to gallstones. […] Dr. Alarcon says less than half of the people diagnosed with gallbladder cancer will have localized disease, meaning their cancer hasn’t spread to the lymph nodes, while 25% of patients will learn their cancer has spread to their lymph nodes and the remaining percentage will have distant metastasis. At later stages, especially if the gallbladder cancer has spread, prognosis is poor, she says. […] Gallbladder cancer needs to be addressed and treated as soon as possible. If you have been diagnosed with gallbladder cancer, it’s important to start treatment right away in order to stop the spread of the disease.

• #81 Gallbladder cancer – Symptoms and causes – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/gallbladder-cancer/symptoms-causes/syc-20353370

  Gallbladder cancer may not be found until it’s advanced because it may cause no symptoms. When they happen, the symptoms may be like those of common conditions. […] Gallbladder cancer may have no symptoms. When there are signs and symptoms, they may include: Belly pain, mostly in the upper right part of the belly. Belly bloating. A mass you can feel through the skin. Losing weight without trying. Yellowing of the skin and whites of the eyes, called jaundice. Yellowing of the skin might be harder to see on Black or brown skin. Jaundice typically happens when the gallbladder cancer is very advanced. […] But most gallbladder cancers are found when they’ve grown beyond the gallbladder. Then the chance to survive, called prognosis, often is poor.

• #82 Gallbladder Cancer: Symptoms, Treatment & Prognosis

  https://my.clevelandclinic.org/health/diseases/17013-gallbladder-cancer

  Gallbladder cancer is a rare form of cancer that often doesnt cause signs or symptoms in the early stages. […] Gallbladder cancer begins in the innermost layer of your gallbladder, called the mucosal layer, and spreads outward. It often doesnt cause signs or symptoms in the early stages. Instead, healthcare providers often find the cancer by chance after gallbladder surgery. […] When symptoms appear, theyre similar to more common conditions, like gallstones or a blockage in a bile duct. […] Symptoms include: Upper abdominal pain. Yellowed skin and yellowed whites of your eyes (jaundice). Lumps in your abdomen. Unexplained weight loss. Nausea and vomiting. Bloating. Fever. […] The prognosis for gallbladder cancer tends to be poor because its not usually diagnosed until its advanced. Only about 20% of gallbladder cancers are diagnosed in the early stages. The five-year survival rate for people with metastasized gallbladder cancer is 2%. The survival rate for localized gallbladder cancer is much higher, at 66%.

• #83 How quickly can gallbladder cancer spread? | Roswell Park Comprehensive Cancer Center – Buffalo, NY

  https://www.roswellpark.org/cancertalk/202203/how-quickly-can-gallbladder-cancer-spread

  Gallbladder cancer is a rare and aggressive disease that is often found incidentally because there are no screening tests for gallbladder cancer like there are for some other cancers, which makes it harder to find the disease at an early stage. […] The majority of people with early disease have no symptoms or will present with nonspecific symptoms like abdominal pain, nausea, vomiting or loss of appetite that resemble gallstone disease or cholecystitis, said Sylvia Alarcon, MD, a former medical oncologist specializing in gastrointestinal cancers at Roswell Park Comprehensive Cancer Center. […] Patients are often diagnosed incidentally with gallbladder cancer during or after surgery to remove the gallbladder due to gallstones. […] Dr. Alarcon says less than half of the people diagnosed with gallbladder cancer will have localized disease, meaning their cancer hasn’t spread to the lymph nodes, while 25% of patients will learn their cancer has spread to their lymph nodes and the remaining percentage will have distant metastasis. At later stages, especially if the gallbladder cancer has spread, prognosis is poor, she says. […] Gallbladder cancer needs to be addressed and treated as soon as possible. If you have been diagnosed with gallbladder cancer, it’s important to start treatment right away in order to stop the spread of the disease.

• #84 Gallbladder Cancer

  https://pmc.ncbi.nlm.nih.gov/articles/PMC3104187/

  Carcinoma of the gallbladder is notoriously lethal. Complete surgical extirpation is the only effective treatment. Because early symptoms are vague and anatomically the gallbladder lacks a serosa to limit the spreading of cancer, the diagnosis of gallbladder cancer frequently occurs at an advanced stage, typically with an abysmal prognosis. Its 5-year survival rate is less than 5% for more advanced stages. […] A common presentation for early-stage gallbladder cancer mimics cholecystitis with upper abdominal pain similar to biliary colic and the presence of cholelithiasis. […] Late stages present with anorexia, malaise, weight loss, nausea, vomiting, or cholestatic jaundice. These features, particularly jaundice indicating bile duct involvement, carry a dismal prognosis.

• #85 How quickly can gallbladder cancer spread? | Roswell Park Comprehensive Cancer Center – Buffalo, NY

  https://www.roswellpark.org/cancertalk/202203/how-quickly-can-gallbladder-cancer-spread

  Gallbladder cancer is a rare and aggressive disease that is often found incidentally because there are no screening tests for gallbladder cancer like there are for some other cancers, which makes it harder to find the disease at an early stage. […] The majority of people with early disease have no symptoms or will present with nonspecific symptoms like abdominal pain, nausea, vomiting or loss of appetite that resemble gallstone disease or cholecystitis, said Sylvia Alarcon, MD, a former medical oncologist specializing in gastrointestinal cancers at Roswell Park Comprehensive Cancer Center. […] Patients are often diagnosed incidentally with gallbladder cancer during or after surgery to remove the gallbladder due to gallstones. […] Dr. Alarcon says less than half of the people diagnosed with gallbladder cancer will have localized disease, meaning their cancer hasn’t spread to the lymph nodes, while 25% of patients will learn their cancer has spread to their lymph nodes and the remaining percentage will have distant metastasis. At later stages, especially if the gallbladder cancer has spread, prognosis is poor, she says. […] Gallbladder cancer needs to be addressed and treated as soon as possible. If you have been diagnosed with gallbladder cancer, it’s important to start treatment right away in order to stop the spread of the disease.

• #86 Gallbladder cancer: Symptoms, diagnosis, treatment, and more

  https://www.medicalnewstoday.com/articles/gallbladder-cancer

  Gallbladder cancer is a rare form of cancer that starts in the inner tissue of the gallbladder. Some people may not notice any symptoms in the early stages. […] This means gallbladder cancer is often hard to detect early, as doctors often do not discover it until a person develops symptoms in the later stages. […] Gallbladder cancer does not always cause symptoms in early, easily treatable stages. They often appear in more advanced stages when the cancer has spread. […] When they do occur, symptoms may include: abdominal pain, nausea and vomiting, abdominal lumps, jaundice. […] Less common symptoms can include: fever, abdominal swelling, weight loss, dark urine, light-colored or greasy stools, loss of appetite, itchy skin. […] No tests or screenings can check for gallbladder cancer. It also does not typically cause symptoms until later stages. […] Treatment often involves the removal of the gallbladder, though it may also include radiation or chemotherapy. A person’s highest chance of success happens when doctors detect the cancer early.

• #87 Gallbladder Cancer | Duke Health

  https://www.dukehealth.org/treatments/cancer/gallbladder-cancer

  Gallbladder cancer is rare and can be hard to diagnose early because of its small size and position under your liver. Most gallbladder cancers are discovered after they’ve grown, so it’s important to receive treatment as soon as possible to prevent the cancer from spreading to other organs. […] People often experience abdominal pain, nausea, and jaundice, a yellowing of your skin or the whites of your eyes. […] If your gallbladder is swollen, your provider may be able to feel the tumor and identify its location. […] If you have jaundice (yellowing of the skin), you may need to undergo an ERCP to place a stent into the blocked bile duct. […] If tests indicate the cancer has spread, exploratory surgery may be performed so your surgeon can evaluate your gallbladder and surrounding organs.

• #88

  https://winshipcancer.emory.edu/cancer-types-and-treatments/gallbladder-cancer/diagnosis.php

  Diagnosing your gallbladder cancer can be challenging. Patients are often asymptomatic, and as many as 70% of gallbladder cancers are discovered postoperatively or after a procedure for another condition. […] Gallbladder cancer symptoms are usually felt only when the cancer has reached an advanced stage. Some of the more common signs and symptoms of gallbladder cancer can include: […] You should speak with your doctor if you are experiencing any of the above symptoms. But keep in mind that gallbladder cancer is rare, and these symptoms are more likely to be caused by something else. […] In later stages, the cancer has grown and possibly spread to other locations in the body such as the liver, lung, bones or lymph nodes.

• #89 How quickly can gallbladder cancer spread? | Roswell Park Comprehensive Cancer Center – Buffalo, NY

  https://www.roswellpark.org/cancertalk/202203/how-quickly-can-gallbladder-cancer-spread

  Gallbladder cancer is a rare and aggressive disease that is often found incidentally because there are no screening tests for gallbladder cancer like there are for some other cancers, which makes it harder to find the disease at an early stage. […] The majority of people with early disease have no symptoms or will present with nonspecific symptoms like abdominal pain, nausea, vomiting or loss of appetite that resemble gallstone disease or cholecystitis, said Sylvia Alarcon, MD, a former medical oncologist specializing in gastrointestinal cancers at Roswell Park Comprehensive Cancer Center. […] Patients are often diagnosed incidentally with gallbladder cancer during or after surgery to remove the gallbladder due to gallstones. […] Dr. Alarcon says less than half of the people diagnosed with gallbladder cancer will have localized disease, meaning their cancer hasn’t spread to the lymph nodes, while 25% of patients will learn their cancer has spread to their lymph nodes and the remaining percentage will have distant metastasis. At later stages, especially if the gallbladder cancer has spread, prognosis is poor, she says. […] Gallbladder cancer needs to be addressed and treated as soon as possible. If you have been diagnosed with gallbladder cancer, it’s important to start treatment right away in order to stop the spread of the disease.

• #90 Early Detection of Gallbladder Cancer: Symptoms and Screening Options – Ezra

  https://ezra.com/blog/early-detection-gallbladder-cancer

  The loss of appetite often associated with gallbladder cancer can lead to unintended weight loss. […] Gallbladder cancer is a far more treatable disease when it is detected in its early stages, especially before it has spread to the liver and other organs. […] Detecting gallbladder cancer early improves prognosis and often enhances quality of life. […] Recognizing its early symptoms and acting quickly can make a crucial difference. […] Understanding the warning signs, such as abdominal pain, jaundice, and digestive discomfort, and being aware of risk factors can help individuals to seek timely medical advice.

• #91 Gallbladder Cancer Treatment – NCI

  https://www.cancer.gov/types/gallbladder/patient/gallbladder-treatment-pdq

  Signs and symptoms of gallbladder cancer include jaundice, fever, and pain. […] Gallbladder cancer is difficult to detect (find) and diagnose early. […] People rarely have signs or symptoms in the early stages of gallbladder cancer. […] The symptoms of gallbladder cancer, when present, are like the symptoms of many other illnesses. […] Gallbladder cancer is sometimes found when the gallbladder is removed for other reasons. […] Gallbladder cancer can be cured only if it is found before it has spread, when it can be removed by surgery. […] If the cancer has spread, palliative treatment can improve the patient’s quality of life by controlling the symptoms and complications of this disease. […] Metastatic gallbladder cancer may spread to surrounding tissues, organs, throughout the abdominal cavity, or to distant parts of the body.

• #92 Gallbladder Cancer: Symptoms, Treatment & Prognosis

  https://my.clevelandclinic.org/health/diseases/17013-gallbladder-cancer

  Gallbladder cancer can only be cured if caught and treated early. To cure gallbladder cancer, your healthcare provider must remove it before it spreads to other organs. […] Gallbladder cancer is a rare and very serious disease. Be sure to see your healthcare provider as soon as possible if you experience the symptoms of gallbladder cancer. While other cancers show signs early on, remember that gallbladder cancer may not be obvious until its in the later stages. Its vital to get treated as soon as possible.

• #93 Symptoms of gallbladder cancer – NHS

  https://www.nhs.uk/conditions/gallbladder-cancer/symptoms/

  Non-urgent advice: See a GP if you have: a lump in your tummy […] symptoms of gallbladder cancer, such as pain or swelling in your tummy, that get worse or do not get better after 2 weeks. […] Many of these symptoms are very common and can be caused by many different conditions. […] Having them does not definitely mean you have gallbladder cancer. But it’s important to get them checked by a GP. […] This is because if they’re caused by cancer, finding it earlier makes it more treatable.

• #94 Signs of Gallbladder Cancer | Symptoms of Gallbladder Cancer | American Cancer Society

  https://www.cancer.org/cancer/types/gallbladder-cancer/detection-diagnosis-staging/signs-and-symptoms.html

  If the cancer blocks the bile ducts, the gallbladder can swell. Gallbladder cancer can also spread to nearby parts of the liver. These changes can sometimes be felt by the doctor as lumps on the right side of the belly. They can also be seen on imaging tests such as an ultrasound. […] Less common symptoms of gallbladder cancer include: […] Keep in mind: Gallbladder cancer is rare. These symptoms are more likely to be caused by something other than gallbladder cancer. […] Still, if you have any of these problems, its important to see a doctor right away so the cause can be found and treated, if needed.

• #95 Gallbladder Cancer Symptoms | Modern Cancer Hospital Guangzhou, China

  https://www.asiancancer.com/en/cancer-symptoms/gallbladder-cancer-symptoms/

  There are few symptoms and no specificity in early gallbladder cancer, but early detection and early treatment are the key to increase survival rate. As mentioned above, active surgery has certain significance for improvement of survival rate. If you suspect yourself for developing gallbladder cancer and you cannot distinguish between normal and abnormal signs, you need to ask for help from doctor as soon as possible. If you are diagnosed with gallbladder cancer, immediate treatment should be done so as to prevent it getting worse. […] Normally gallbladder cancer comes without special clinical symptoms or only develops the symptoms of chronic cholecystitis. The early diagnosis of it is hard that once constant pain, lump, jaundice occur, a patient is already in late stages. […] Symptoms of gallbladder cancer: 1. Symptoms of enteron. Most patients (about 90%) develop dyspepsia, aversion to greasy food, belching, poor appetite and other symptoms because of functional defect of gallbladder, which means the patients cannot digest fatty material. 2. Pain in right upper abdomen. Over 80% gallbladder cancer patients are suffering from cholecystolithiasis at the same time that some similar symptoms of cholecystolithiasis or cholecystitis develop. Most cases would present the pain in right upper abdomen first, which would develop to constant vague or dull pain and occasionally accompanied by the paroxysmal acute pain that can extend to right shoulder. 3. Lump in right upper abdomen. About 50% patients develop the lump in right upper abdomen or upper abdominal regions, among them mostly are enlarged gallbladder. 4. Jaundice and skin itch normally appear in late stage of gallbladder cancer. Obstruction of bile duct resulted by cancer tissues encroaching on bile ducts or swelling metastatic lymph nodes depressing on bile ducts that the bile secreted by liver cannot enter intestines but flows black to blood would lead to yellow satin in skin and mucous membrane. And a patient with jaundice is normally accompanied by the skin itch that is hard to relieve and may aggravates at night. 5. Fever and emaciation. Around 25% patients would present fever, which causes from secondary infection of biliary tract. Cachexia may even develop in late stage patients as well.

• #96 Gall bladder (bile duct) cancer

  https://www.cancervic.org.au/cancer-information/types-of-cancer/gall_bladder_cancer/gall-bladder-cancer-overview.html

  Gall bladder cancer can be difficult to diagnose in its early stages as it doesnt usually cause symptoms. If symptoms do occur, they can include: abdominal pain, often on the upper right side […] Gall bladder cancer is sometimes suspected when there is a large gall bladder polyp (greater than 1 cm) or a calcified gall bladder.

• #97 Symptoms of gallbladder cancer – NHS

  https://www.nhs.uk/conditions/gallbladder-cancer/symptoms/

  Non-urgent advice: See a GP if you have: a lump in your tummy […] symptoms of gallbladder cancer, such as pain or swelling in your tummy, that get worse or do not get better after 2 weeks. […] Many of these symptoms are very common and can be caused by many different conditions. […] Having them does not definitely mean you have gallbladder cancer. But it’s important to get them checked by a GP. […] This is because if they’re caused by cancer, finding it earlier makes it more treatable.

• #98 Gallbladder Cancer Signs, Symptoms and Types | Banner Health

  https://www.bannerhealth.com/services/cancer/cancer-type/gallbladder-cancer/symptoms-and-types

  Bloating: A feeling of fullness, even after eating a small amount. […] Fatigue: Feeling tired or weak. […] Fever: Body temperature may increase in response to cancer. […] Abdominal mass: You may notice a lump or mass in the upper right abdomen. […] If you have any of these symptoms, especially abdominal pain that doesnt ease up, jaundice or unexplained weight loss, see a health care provider. Its also important to see a provider if you have a history of gallstones or gallbladder inflammation and you have new symptoms, or your symptoms are getting worse.

• #99 Gallbladder Cancer Signs, Symptoms and Types | Banner Health

  https://www.bannerhealth.com/services/cancer/cancer-type/gallbladder-cancer/symptoms-and-types

  Bloating: A feeling of fullness, even after eating a small amount. […] Fatigue: Feeling tired or weak. […] Fever: Body temperature may increase in response to cancer. […] Abdominal mass: You may notice a lump or mass in the upper right abdomen. […] If you have any of these symptoms, especially abdominal pain that doesnt ease up, jaundice or unexplained weight loss, see a health care provider. Its also important to see a provider if you have a history of gallstones or gallbladder inflammation and you have new symptoms, or your symptoms are getting worse.

• #100 Symptoms of gallbladder cancer | Macmillan Cancer Support

  https://www.macmillan.org.uk/cancer-information-and-support/gallbladder-cancer/symptoms-of-gallbladder-cancer

  Most gallbladder cancers are found at an advanced stage. Symptoms include sickness, high temperature, weight loss and tummy pain. […] Early gallbladder cancer does not usually cause symptoms. It is often found when someone has surgery to remove gallstones. But most people who have surgery for gallstones will not have gallbladder cancer. […] Most gallbladder cancers are found at an advanced stage. They can cause different symptoms, including: sickness, high temperatures (fevers), weight loss, pain in the tummy (abdomen). […] If the cancer blocks the bile duct, it may stop the flow of bile from the gall bladder into the small bowel. This causes bile to flow back into the blood and body tissues. This can cause: yellowing of the skin and whites of the eyes (jaundice), your pee (urine) to become a dark yellow colour, pale poo (stools), itchy skin. […] These symptoms may be caused by other problems. But it is important to get them checked by your GP.

• #101

  https://111.wales.nhs.uk/encyclopaedia/c/article/cancerofthegallbladder

  Gallbladder cancer may not have any symptoms, or they might be hard to spot. […] Symptoms of gallbladder cancer include: the whites of your eyes turning yellow or your skin turning yellow, which may be less obvious on brown or black skin (jaundice) you may also have itchy skin, darker pee and paler poo than usual. […] Other symptoms can affect your digestion, such as: feeling or being sick, aching pain in the right side of your tummy, sometimes described as a „dragging feeling”, sharp pain in your tummy, a very swollen tummy that is not related to when you eat. […] It’s important to get any symptoms of gallbladder cancer checked by a GP. […] Many of these symptoms are very common and can be caused by many different conditions. […] Having them does not definitely mean you have gallbladder cancer. But it’s important to get them checked by a GP. […] This is because if they’re caused by cancer, finding it earlier makes it more treatable.

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