Materiały źródłowe

• #1 Germ Cell Tumors (GCTs) in Children | Cedars-Sinai

  https://www.cedars-sinai.org/health-library/diseases-and-conditions—pediatrics/g/germ-cell-tumors-in-children.html

  Germ cell tumors (GCTs) are made up of these underdeveloped cells. These tumors are rare. They may be cancer (malignant) or not cancer (benign). […] GCTs can be treated with any of these: […] Surgery. This is done to take out the tumor and an edge of nearby normal tissue (surgical margin). The organ where the tumor is growing may also be removed. For instance, this may be an ovary or testicle. […] Chemotherapy. These are strong medicines that kill cancer cells. They may be given by mouth, right into the blood through a vein (IV), or in other ways. […] Radiation therapy. These are high-energy X-rays or other types of radiation. Radiation is used to kill cancer cells or stop them from growing. […] Supportive care. Treatment can cause side effects. Medicines and other treatments can be used for things like pain, fever, infection, and nausea and vomiting. Managing side effects is a key part of good cancer treatment.

• #2 Germ Cell Tumor: Causes & Symptoms

  https://my.clevelandclinic.org/health/diseases/23505-germ-cell-tumor

  Surgery is the primary treatment for germ cell tumors. Your provider may remove the tumor from the affected ovary (ovarian cystectomy) or the entire ovary and fallopian tubes (salpingo-oophorectomy). With testicular cancer, your provider will remove the testicle with the tumor. […] Chemotherapy uses drugs to destroy cancer cells or prevent them from dividing. You might receive chemotherapy if your provider can’t remove the tumor safely or if it has spread to other parts of your body. You may receive chemotherapy to destroy any remaining cancer cells following surgery, even if you can’t see the cancer cells on imaging. Chemotherapy is an effective treatment for most types of germ cell tumors. […] Radiation therapy directs high-energy X-rays to cancer cells to destroy them. Some types of germ cell tumors respond best to radiation therapy. […] If your child has a germ cell tumor, you’ll want expert, compassionate care. Cleveland Clinic Children’s providers will tailor treatment to all your child’s needs.

• #3 Germ cell tumors

  https://www.umassmed.edu/cancer-center/patients/pediatric-cancer/cancer-types/germ-cell-tumors/

  Germ cells are specialized types of cells that develop in a fetus (unborn baby) and give rise to other cells needed for reproduction. Their name comes from the word germinate, which means to begin to grow. As a child matures, germ cells eventually give rise to sperm in the testicles of boys or to unfertilized eggs in the ovaries of girls. In rare instances, tumors can form in these germ cells (referred to as gonadal germ cell tumors), which can be either malignant (cancerous) or benign (noncancerous). […] Occasionally, germ cell tumors form from developing sperm or egg cells that travel to other parts of the body, such as the brain, abdomen, lower spine, or the area between the lungs. These tumors are referred to as extragonadal germ cell tumors and are most common in adolescents. […] Meet the team of pediatric oncologists who diagnose, treat and care for patients with germ cell tumors.

• #4 Germ Cell Tumors (Solid Tumor) Treatment | St. Jude Care & Treatment

  https://www.stjude.org/care-treatment/treatment/childhood-cancer/solid-tumors/germ-cell-tumors-solid-tumor.html

  Germ cell tumors are rare. They are more common in people with certain inherited disorders (passed down through families). They are also more common in males with a history of undescended testicles. […] St. Jude provides the highest quality of care for patients with germ cell tumors: The medical team works closely with lab researchers to bring new treatments from the lab to the clinic. Ongoing research is focused on shortening how long patients receive chemo. The goal is to keep excellent survival rates but reduce the risk of long-term side effects. St. Jude offers a dedicated team of specialists to meet the needs of children with cancer, including: Surgeons, doctors, and nurses who treat this cancer. […] The nurse-to-patient ratio at St. Jude is about 1:3 in hematology and oncology and 1:1 in the Intensive Care Unit.

• #5 Ovarian Germ Cell Tumors – UChicago Medicine

  https://www.uchicagomedicine.org/cancer/types-treatments/ovarian-cancer/ovarian-germ-cell-tumors

  Ovarian germ cell tumors can be non-cancerous (benign) or cancerous (malignant). […] Malignant OGCT make up only 5% of all ovarian cancers and are commonly diagnosed in women between 10 and 30 years of age. […] Usually, malignant OGCTs are treated with surgery. […] Because OGCTs often occur in young/reproductive age patients, a fertility-sparing procedure can be considered to leave the unaffected ovary and uterus in place. […] Based on the risk of recurrence, patients may need to receive a combination of chemotherapy drugs after surgery. […] Generally, chemotherapy is the mainstay of treatment for recurrent ovarian germ cell tumors. […] Our team is made up of specialists in several areas, including gynecologic oncology, gynecologic pathology, radiology, radiation oncology, oncofertility, supportive oncology, nursing and more.

• #6 Childhood Germ Cell Tumors | Dana-Farber Cancer Institute

  https://www.dana-farber.org/cancer-care/types/childhood-germ-cell-tumors

  Germ cell tumors are tissue masses formed by immature cells that usually become mature eggs or sperm. They can be benign (noncancerous) or malignant (cancerous). […] At Dana-Farber/Boston Children’s Cancer and Blood Disorders Center, your child will receive care from top pediatric cancer doctors with deep specialized experience and expertise. Doctors in the Rare Tumors Program, within our Solid Tumor Center, care for children with germ cell tumors. […] After we complete all diagnostic testing, a team of pediatric tumor experts comes together to decide on the best treatment plan for your child. We meet with you and your family to discuss our treatment recommendations and answer any questions. […] We use the full spectrum of available treatments for germ cell tumors, including advanced surgery and promising clinical trials.

• #7 Germ cell tumors

  https://www.umassmed.edu/cancer-center/patients/pediatric-cancer/cancer-types/germ-cell-tumors/

  Germ cells are specialized types of cells that develop in a fetus (unborn baby) and give rise to other cells needed for reproduction. Their name comes from the word germinate, which means to begin to grow. As a child matures, germ cells eventually give rise to sperm in the testicles of boys or to unfertilized eggs in the ovaries of girls. In rare instances, tumors can form in these germ cells (referred to as gonadal germ cell tumors), which can be either malignant (cancerous) or benign (noncancerous). […] Occasionally, germ cell tumors form from developing sperm or egg cells that travel to other parts of the body, such as the brain, abdomen, lower spine, or the area between the lungs. These tumors are referred to as extragonadal germ cell tumors and are most common in adolescents. […] Meet the team of pediatric oncologists who diagnose, treat and care for patients with germ cell tumors.

• #8 Childhood Germ Cell Tumor of the Brain | Dana-Farber Cancer Institute

  https://www.dana-farber.org/cancer-care/types/childhood-germ-cell-tumor-of-the-brain

  Germ cell tumors that develop in the brain or spinal cord are also called CNS (central nervous system) germ cell tumors. […] At Dana-Farber/Boston Children’s Cancer and Blood Disorders Center, your child will receive care at one of the largest and most experienced pediatric brain tumor treatment programs in the world. Within the Childhood Brain Tumor Center, our specialists have extensive expertise in treating all types of brain tumors, including germ cell tumors. […] Successfully treating your child’s germ cell tumor depends on identifying the tumor type and location. […] After we complete all diagnostic testing, a team of pediatric tumor experts comes together to decide on the best treatment plan for your child. […] Your child’s treatment plan will depend on their age, health, and medical history, as well as the tumors characteristics.

• #9 Germ Cell Tumors | Conditions | UCSF Benioff Children’s Hospitals

  https://www.ucsfbenioffchildrens.org/conditions/germ-cell-tumors

  Where to get care […] Your child’s treatment options will depend on the type of germ cell tumor, its location and whether the disease has spread to other parts of the body. In some cases, it’s possible to perform surgery to remove the tumor completely. […] Some germ cell tumors can be treated with radiation therapy either alone or in combination with surgery. Radiation therapy uses high-dose X-rays or other radiation sources to kill cancer cells. […] Chemotherapy is effective for malignant germ cell tumors and almost always used in combination with surgery. It may be given before surgery to shrink a large tumor (making it easier to remove) or after surgery to kill any cancer cells left behind. […] Your child may be able to receive promising experimental treatments by participating in a clinical trial.

• #10 Nursing Care Plan (NCP) for Testicular Cancer | Free NURSING.com Courses

  https://nursing.com/lesson/nursing-care-plan-ncp-for-testicular-cancer

  To equip nursing professionals with a comprehensive framework for managing patients with testicular cancer. The plan focuses on understanding the diseases pathophysiology, recognizing its symptoms, and implementing effective nursing interventions for symptom management, complication prevention, and emotional support. […] This care plan is dedicated to providing holistic management for patients with testicular cancer, focusing on symptom relief, emotional support, patient education, and addressing concerns about fertility and body image. Customizing care to individual patient needs and concerns is crucial for effective management and improved quality of life.

• #11 Germ cell tumors – Care at Mayo Clinic – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/germ-cell-tumors/care-at-mayo-clinic/mac-20352496

  Mayo Clinic doctors have extensive experience diagnosing and treating germ cell tumors, including ovarian cancer and testicular cancer. They draw on this knowledge to provide you with a personalized treatment plan that provides you with exactly the care you need. […] At Mayo Clinic, specialists in urology, gynecology, surgery, pathology, medical oncology and radiation oncology work together to care for people with germ cell tumors. For children diagnosed with germ cell tumors, pediatric oncologists lead care teams with special expertise in caring for children. Other professionals are included as needed. […] Mayo Clinic doctors and other specially trained health care professionals have access to the latest diagnosis and treatment technology to provide you with the best chance for a successful outcome. […] Experts will work with you to review all of your treatment options and choose the treatment that best suits your needs and goals. Your treatment options will depend on the specifics of your tumor, but may include surgery, chemotherapy and radiation therapy.

• #12 Get Germ Cell Tumor Treatment | Cleveland Clinic Children’s

  https://my.clevelandclinic.org/pediatrics/services/germ-cell-tumor-treatment

  Germ cell tumors may be cancerous or noncancerous. Either way, finding out your child has one can be unsettling. At Cleveland Clinic Childrens, well provide personalized care and compassionate support for your whole family, from diagnosis throughout treatment and beyond. […] If tests confirm your child has a germ cell tumor, their treatment will depend on a few things: What kind of germ cell tumor it is (if its cancerous or not), how big the tumor is and if its spread (the stage), where the tumor is. […] Surgery to remove the tumor and, sometimes, the affected organ is the main treatment for germ cell tumors. If the tumor is cancerous, your child might also have chemotherapy after surgery. Chemo uses drugs to destroy any remaining cancer cells or keep them from dividing. It can also be the main treatment if the tumor cant be removed safely, or its spread to other parts of your childs body.

• #13 Germ Cell Tumors – Brigham and Women’s Hospital

  https://www.brighamandwomens.org/lung-center/diseases-and-conditions/germ-cell-tumors

  Patients who have benign teratomas or who have tumors remaining after chemotherapy or radiation therapy may need to have surgery in order to remove these tumors completely. At BWH, our thoracic surgeons are experts in the use of minimally invasive surgical techniques such as video-assisted thoracic surgery (VATS) and robotic-assisted mediastinal tumor resection, alternatives to open chest surgery. […] Any recommended surgery will be performed by an experienced, board-certified surgeon in collaboration with a treatment team including nurses and physician assistants, all of whom specialize in taking care of patients with germ cell tumors.

• #14 Germ cell tumors – Diagnosis and treatment – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/germ-cell-tumors/diagnosis-treatment/drc-20580169

  Our caring team of Mayo Clinic experts can help you with your germ cell tumors-related health concerns […] Treatments for germ cell tumors may include surgery, chemotherapy and radiation therapy. […] Surgery is often used to take out a germ cell tumor. The kind of surgery used to remove a germ cell tumor may depend on the tumor’s location. If a tumor in a testicle might be cancer, surgery often includes removing the entire testicle. […] Chemotherapy treats cancer with strong medicines. Many chemotherapy medicines exist. Most chemotherapy medicines are given through a vein. Some come in pill form. […] Radiation therapy treats cancer with powerful energy beams. The energy can come from X-rays, protons or other sources. During radiation therapy, you lie on a table while a machine moves around you. The machine directs radiation to precise points on the body.

• #15 Germ Cell Tumors – Brigham and Women’s Hospital

  https://www.brighamandwomens.org/lung-center/diseases-and-conditions/germ-cell-tumors

  Patients who have benign teratomas or who have tumors remaining after chemotherapy or radiation therapy may need to have surgery in order to remove these tumors completely. At BWH, our thoracic surgeons are experts in the use of minimally invasive surgical techniques such as video-assisted thoracic surgery (VATS) and robotic-assisted mediastinal tumor resection, alternatives to open chest surgery. […] Any recommended surgery will be performed by an experienced, board-certified surgeon in collaboration with a treatment team including nurses and physician assistants, all of whom specialize in taking care of patients with germ cell tumors.

• #16 Surgery for Germ Cell Tumors | NYU Langone Health

  https://nyulangone.org/conditions/germ-cell-tumors-in-children/treatments/surgery-for-germ-cell-tumors

  Surgeons at Hassenfeld Childrens Hospital at NYU Langone remove many types of benign and malignant germ cell tumors. The surgery used for germ cell tumors depends on the type, size, and location of the tumor. Chemotherapy may be used to shrink large tumors before surgery to make them easier to remove. […] Surgery alone can cure some malignant germ cell tumors in the gonads—the ovaries or testicles. For germ cell tumors in the testicles, a surgeon removes the tumor and one or both testicles through a small incision in the groin. For ovarian germ cell tumors, which typically appear on one ovary, the surgeon removes the tumor, the ovary, and the fallopian tube through a small incision in the abdomen. Leaving one ovary or testicle when possible can help preserve fertility. […] Surgery for extragonadal tumors—those located outside the gonads—depends on the location of the tumor. Some tumors can’t be completely removed because they are wrapped in nerves or arteries that supply blood to organs or are pressed against an important organ, such as the heart. A surgical procedure called tumor debulking, or cytoreduction, is used to remove as much of this kind of tumor or as many of these tumors as possible.

• #17 Surgery for Germ Cell Tumors | NYU Langone Health

  https://nyulangone.org/conditions/germ-cell-tumors-in-children/treatments/surgery-for-germ-cell-tumors

  The doctor may perform a biopsy on nearby lymph nodes to determine if the cancer has spread beyond its original location. After surgery, chemotherapy is used to destroy any remaining malignant tumor or tumors, which are typically smaller than 1 centimeter. […] The side effects of surgery depend on the location and the size of tumor. […] During surgery for testicular and ovarian germ cell tumors that affect the sacrum and coccyx, the bones at the bottom of the spine, the affected bones may have to be removed. […] Your doctor discusses preserving your child’s fertility with you. A prosthesis of the testicle or testicles can be surgically implanted in the scrotum for a more natural appearance.

• #18 Germ Cell Tumors (GCTs) in Children | Cedars-Sinai

  https://www.cedars-sinai.org/health-library/diseases-and-conditions—pediatrics/g/germ-cell-tumors-in-children.html

  Germ cell tumors (GCTs) are made up of these underdeveloped cells. These tumors are rare. They may be cancer (malignant) or not cancer (benign). […] GCTs can be treated with any of these: […] Surgery. This is done to take out the tumor and an edge of nearby normal tissue (surgical margin). The organ where the tumor is growing may also be removed. For instance, this may be an ovary or testicle. […] Chemotherapy. These are strong medicines that kill cancer cells. They may be given by mouth, right into the blood through a vein (IV), or in other ways. […] Radiation therapy. These are high-energy X-rays or other types of radiation. Radiation is used to kill cancer cells or stop them from growing. […] Supportive care. Treatment can cause side effects. Medicines and other treatments can be used for things like pain, fever, infection, and nausea and vomiting. Managing side effects is a key part of good cancer treatment.

• #19 Pharmacotherapeutic treatment of germ cell tumors: standard of care and recent developments – PubMed

  https://pubmed.ncbi.nlm.nih.gov/26630452/

  Testicular germ cell tumors are the most common malignancy among men aged 40 and less. […] Since the introduction of cisplatin-based combination chemotherapy, germ cell tumors are among the most curable solid tumors with cure rates of 95% in all patients and 80% in metastatic disease. […] Maintaining therapeutic success while further reducing treatment-related toxicity is paramount. […] Cancer-specific survival in localized disease approximates 100%. […] Therefore, orchidectomy followed by active surveillance is the preferred approach for all seminomas and non-seminomas lacking lymphovascular invasion. […] Non-seminomas with lymphovascular invasion should be offered adjuvant treatment with one cycle of bleomycin, etoposide and cisplatin (BEP). […] The BEP regimen remains standard of care for metastatic disease, while the role of primary high-dose chemotherapy in case of inadequate tumor-marker decline or presence of high-risk features (i.e. mediastinal origin, non-pulmonary visceral metastases) remains to be elucidated. […] Several curative salvage chemotherapy combinations are available, i.e. TIP, VeIP, GIP or high-dose carboplatin and etoposide. […] GOP is the current option of choice in cisplatin-refractory patients. […] Novel targeted agents failed to improve treatment outcome so far.

• #20 Pharmacotherapeutic treatment of germ cell tumors: standard of care and recent developments – PubMed

  https://pubmed.ncbi.nlm.nih.gov/26630452/

  Testicular germ cell tumors are the most common malignancy among men aged 40 and less. […] Since the introduction of cisplatin-based combination chemotherapy, germ cell tumors are among the most curable solid tumors with cure rates of 95% in all patients and 80% in metastatic disease. […] Maintaining therapeutic success while further reducing treatment-related toxicity is paramount. […] Cancer-specific survival in localized disease approximates 100%. […] Therefore, orchidectomy followed by active surveillance is the preferred approach for all seminomas and non-seminomas lacking lymphovascular invasion. […] Non-seminomas with lymphovascular invasion should be offered adjuvant treatment with one cycle of bleomycin, etoposide and cisplatin (BEP). […] The BEP regimen remains standard of care for metastatic disease, while the role of primary high-dose chemotherapy in case of inadequate tumor-marker decline or presence of high-risk features (i.e. mediastinal origin, non-pulmonary visceral metastases) remains to be elucidated. […] Several curative salvage chemotherapy combinations are available, i.e. TIP, VeIP, GIP or high-dose carboplatin and etoposide. […] GOP is the current option of choice in cisplatin-refractory patients. […] Novel targeted agents failed to improve treatment outcome so far.

• #21 Treatment of Germ Cell Tumors and Sex Cord Stromal Tumors | Memorial Sloan Kettering Cancer Center

  https://www.mskcc.org/pediatrics/cancer-care/types/germ-cell-tumors-sex-cord-tumors/treatment

  If your child needs chemotherapy, they may get the drugs cisplatin, etoposide, and bleomycin. […] Your care team will tell you what to expect. They will support your child and help manage any side effects. […] If your child has surgery, your surgeon will let you know how long the surgery may take. […] If your child has chemotherapy, side effects can include nausea and vomiting, less appetite, hair loss, and mouth sores. […] At MSK Kids, we try whenever possible to use treatments that have the best chance of curing the cancer with the lowest risk of late effects. […] We will keep monitoring (checking) your childs health after their treatment ends. You must come in for visits every now and then so we can be sure the tumor is gone. […] We encourage the children we treat for these tumors to get follow-up care through the MSK Kids long-term follow-up program.

• #22

  http://waocp.com/journal/index.php/apjcc/article/view/346

  Most of the cases presented with advanced stage and majority of them had undergone high inguinal orchidectomy. […] The high nodal burden disease at presentation was associated with partial response to standard chemotherapy. […] It seems that there is the need of alternative chemotherapy regimen especially in nonseminomatous germ cell tumors. […] Patients presenting with disease confined to locoregional lymph nodes or local disease showed good prognosis. […] Systemic chemotherapy was indicated in 94.7% and not indicated in only 5.3% of patients. […] Neoadjuvant chemotherapy was considered in 21.1% of cases and these are the patients not able to undergo upfront surgery. […] Adjuvant chemotherapy was not taken or defaulted by 18.4% of patients and 81.6% of patients completed their scheduled chemotherapy.

• #23

  http://waocp.com/journal/index.php/apjcc/article/view/346

  Neutropenia was the most common complication followed by diarrhoea and pulmonary toxicity was least common. […] Toxicities of the chemotherapy led to the delay in treatment schedule. […] Overall survival in our study was not matching to the data of western studies the reason for this may be advanced disease at presentation, bulky retroperitoneal nodal disease, treatment abandonment, failure to maintain dose intensity and lost to proper follow up.

• #24 Treatment of Germ Cell Tumors and Sex Cord Stromal Tumors | Memorial Sloan Kettering Cancer Center

  https://www.mskcc.org/pediatrics/cancer-care/types/germ-cell-tumors-sex-cord-tumors/treatment

  If your child needs chemotherapy, they may get the drugs cisplatin, etoposide, and bleomycin. […] Your care team will tell you what to expect. They will support your child and help manage any side effects. […] If your child has surgery, your surgeon will let you know how long the surgery may take. […] If your child has chemotherapy, side effects can include nausea and vomiting, less appetite, hair loss, and mouth sores. […] At MSK Kids, we try whenever possible to use treatments that have the best chance of curing the cancer with the lowest risk of late effects. […] We will keep monitoring (checking) your childs health after their treatment ends. You must come in for visits every now and then so we can be sure the tumor is gone. […] We encourage the children we treat for these tumors to get follow-up care through the MSK Kids long-term follow-up program.

• #25 Germ cell tumors – Diagnosis and treatment – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/germ-cell-tumors/diagnosis-treatment/drc-20580169

  Our caring team of Mayo Clinic experts can help you with your germ cell tumors-related health concerns […] Treatments for germ cell tumors may include surgery, chemotherapy and radiation therapy. […] Surgery is often used to take out a germ cell tumor. The kind of surgery used to remove a germ cell tumor may depend on the tumor’s location. If a tumor in a testicle might be cancer, surgery often includes removing the entire testicle. […] Chemotherapy treats cancer with strong medicines. Many chemotherapy medicines exist. Most chemotherapy medicines are given through a vein. Some come in pill form. […] Radiation therapy treats cancer with powerful energy beams. The energy can come from X-rays, protons or other sources. During radiation therapy, you lie on a table while a machine moves around you. The machine directs radiation to precise points on the body.

• #26 Germ Cell Tumors (GCTs) in Children | Cedars-Sinai

  https://www.cedars-sinai.org/health-library/diseases-and-conditions—pediatrics/g/germ-cell-tumors-in-children.html

  Germ cell tumors (GCTs) are made up of these underdeveloped cells. These tumors are rare. They may be cancer (malignant) or not cancer (benign). […] GCTs can be treated with any of these: […] Surgery. This is done to take out the tumor and an edge of nearby normal tissue (surgical margin). The organ where the tumor is growing may also be removed. For instance, this may be an ovary or testicle. […] Chemotherapy. These are strong medicines that kill cancer cells. They may be given by mouth, right into the blood through a vein (IV), or in other ways. […] Radiation therapy. These are high-energy X-rays or other types of radiation. Radiation is used to kill cancer cells or stop them from growing. […] Supportive care. Treatment can cause side effects. Medicines and other treatments can be used for things like pain, fever, infection, and nausea and vomiting. Managing side effects is a key part of good cancer treatment.

• #27 Germinoma | UCSF Brain Tumor Center

  https://braintumorcenter.ucsf.edu/condition/germinoma

  Germinoma is typically treated with radiation and in some cases, chemotherapy. Radiation can be curative for a majority of patients, however the long-term effects of this therapy has led to further investigation of treatments that combine chemotherapy with lower volumes and doses of radiation. […] Patients who experience endocrine-related symptoms may also receive hormone replacement therapy. […] Germinoma is a serious condition that needs to be treated by a multidisciplinary team consisting of neurosurgeons, neuro-oncologists and radiation oncologists. However, many patients have positive long-term outcomes. […] For patients with germinoma, long-term outcomes depend on a variety of factors, including the size and location of the tumor, and if applicable, extent of endocrine dysfunction.

• #28 Nursing Care Plan (NCP) for Testicular Cancer | Free NURSING.com Courses

  https://nursing.com/lesson/nursing-care-plan-ncp-for-testicular-cancer

  To equip nursing professionals with a comprehensive framework for managing patients with testicular cancer. The plan focuses on understanding the diseases pathophysiology, recognizing its symptoms, and implementing effective nursing interventions for symptom management, complication prevention, and emotional support. […] This care plan is dedicated to providing holistic management for patients with testicular cancer, focusing on symptom relief, emotional support, patient education, and addressing concerns about fertility and body image. Customizing care to individual patient needs and concerns is crucial for effective management and improved quality of life.

• #29 Germ Cell Tumors – Brigham and Women’s Hospital

  https://www.brighamandwomens.org/lung-center/diseases-and-conditions/germ-cell-tumors

  Patients who have benign teratomas or who have tumors remaining after chemotherapy or radiation therapy may need to have surgery in order to remove these tumors completely. At BWH, our thoracic surgeons are experts in the use of minimally invasive surgical techniques such as video-assisted thoracic surgery (VATS) and robotic-assisted mediastinal tumor resection, alternatives to open chest surgery. […] Any recommended surgery will be performed by an experienced, board-certified surgeon in collaboration with a treatment team including nurses and physician assistants, all of whom specialize in taking care of patients with germ cell tumors.

• #30 Surgery for Germ Cell Tumors | NYU Langone Health

  https://nyulangone.org/conditions/germ-cell-tumors-in-children/treatments/surgery-for-germ-cell-tumors

  Surgeons at Hassenfeld Childrens Hospital at NYU Langone remove many types of benign and malignant germ cell tumors. The surgery used for germ cell tumors depends on the type, size, and location of the tumor. Chemotherapy may be used to shrink large tumors before surgery to make them easier to remove. […] Surgery alone can cure some malignant germ cell tumors in the gonads—the ovaries or testicles. For germ cell tumors in the testicles, a surgeon removes the tumor and one or both testicles through a small incision in the groin. For ovarian germ cell tumors, which typically appear on one ovary, the surgeon removes the tumor, the ovary, and the fallopian tube through a small incision in the abdomen. Leaving one ovary or testicle when possible can help preserve fertility. […] Surgery for extragonadal tumors—those located outside the gonads—depends on the location of the tumor. Some tumors can’t be completely removed because they are wrapped in nerves or arteries that supply blood to organs or are pressed against an important organ, such as the heart. A surgical procedure called tumor debulking, or cytoreduction, is used to remove as much of this kind of tumor or as many of these tumors as possible.

• #31 Surgery for Germ Cell Tumors | NYU Langone Health

  https://nyulangone.org/conditions/germ-cell-tumors-in-children/treatments/surgery-for-germ-cell-tumors

  The doctor may perform a biopsy on nearby lymph nodes to determine if the cancer has spread beyond its original location. After surgery, chemotherapy is used to destroy any remaining malignant tumor or tumors, which are typically smaller than 1 centimeter. […] The side effects of surgery depend on the location and the size of tumor. […] During surgery for testicular and ovarian germ cell tumors that affect the sacrum and coccyx, the bones at the bottom of the spine, the affected bones may have to be removed. […] Your doctor discusses preserving your child’s fertility with you. A prosthesis of the testicle or testicles can be surgically implanted in the scrotum for a more natural appearance.

• #32 Get Germ Cell Tumor Treatment | Cleveland Clinic Children’s

  https://my.clevelandclinic.org/pediatrics/services/germ-cell-tumor-treatment

  For cancerous germ cell tumors, your childs provider may also recommend radiation therapy, which sends high energy X-rays to the cancer cells to destroy them. For some kinds of germ cell tumors, radiation therapy is the best treatment. […] Our follow-up care starts with helping your child recover after surgery, but it doesnt stop there. Well care for your child long after theyve finished treatment. Your child will continue to visit their providers regularly to see how theyre doing and to check their overall health. Well also do tests to make sure a germ cell tumor hasnt come back or there arent any signs of new health conditions that may develop after treatment. […] If your child has a germ cell tumor, youll want to work with pediatric healthcare providers who specialize in treating rare conditions. And youll want compassionate providers who understand how children and teens react to having a serious illness. Youll find that combination of expertise and compassion at Cleveland Clinic Childrens. Well develop personalized care plans that also include support for your child and you as you manage their illness and any long-term challenges.

• #33 Germ Cell Tumors (GCTs) in Children | Cedars-Sinai

  https://www.cedars-sinai.org/health-library/diseases-and-conditions—pediatrics/g/germ-cell-tumors-in-children.html

  Germ cell tumors (GCTs) are made up of these underdeveloped cells. These tumors are rare. They may be cancer (malignant) or not cancer (benign). […] GCTs can be treated with any of these: […] Surgery. This is done to take out the tumor and an edge of nearby normal tissue (surgical margin). The organ where the tumor is growing may also be removed. For instance, this may be an ovary or testicle. […] Chemotherapy. These are strong medicines that kill cancer cells. They may be given by mouth, right into the blood through a vein (IV), or in other ways. […] Radiation therapy. These are high-energy X-rays or other types of radiation. Radiation is used to kill cancer cells or stop them from growing. […] Supportive care. Treatment can cause side effects. Medicines and other treatments can be used for things like pain, fever, infection, and nausea and vomiting. Managing side effects is a key part of good cancer treatment.

• #34

  http://waocp.com/journal/index.php/apjcc/article/view/346

  Most of the cases presented with advanced stage and majority of them had undergone high inguinal orchidectomy. […] The high nodal burden disease at presentation was associated with partial response to standard chemotherapy. […] It seems that there is the need of alternative chemotherapy regimen especially in nonseminomatous germ cell tumors. […] Patients presenting with disease confined to locoregional lymph nodes or local disease showed good prognosis. […] Systemic chemotherapy was indicated in 94.7% and not indicated in only 5.3% of patients. […] Neoadjuvant chemotherapy was considered in 21.1% of cases and these are the patients not able to undergo upfront surgery. […] Adjuvant chemotherapy was not taken or defaulted by 18.4% of patients and 81.6% of patients completed their scheduled chemotherapy.

• #35

  http://waocp.com/journal/index.php/apjcc/article/view/346

  Neutropenia was the most common complication followed by diarrhoea and pulmonary toxicity was least common. […] Toxicities of the chemotherapy led to the delay in treatment schedule. […] Overall survival in our study was not matching to the data of western studies the reason for this may be advanced disease at presentation, bulky retroperitoneal nodal disease, treatment abandonment, failure to maintain dose intensity and lost to proper follow up.

• #36 Germ Cell Tumors (GCTs) in Children | Cedars-Sinai

  https://www.cedars-sinai.org/health-library/diseases-and-conditions—pediatrics/g/germ-cell-tumors-in-children.html

  Germ cell tumors (GCTs) are made up of these underdeveloped cells. These tumors are rare. They may be cancer (malignant) or not cancer (benign). […] GCTs can be treated with any of these: […] Surgery. This is done to take out the tumor and an edge of nearby normal tissue (surgical margin). The organ where the tumor is growing may also be removed. For instance, this may be an ovary or testicle. […] Chemotherapy. These are strong medicines that kill cancer cells. They may be given by mouth, right into the blood through a vein (IV), or in other ways. […] Radiation therapy. These are high-energy X-rays or other types of radiation. Radiation is used to kill cancer cells or stop them from growing. […] Supportive care. Treatment can cause side effects. Medicines and other treatments can be used for things like pain, fever, infection, and nausea and vomiting. Managing side effects is a key part of good cancer treatment.

• #37 Germ Cell Tumors (GCTs) in Children

  https://www.nationwidechildrens.org/conditions/health-library/germ-cell-tumors-gcts-in-children

  Germ cell tumors (GCTs) are made up of these underdeveloped cells. […] GCTs can be treated with any of these: […] Surgery. This is done to take out the tumor and an edge of nearby normal tissue (surgical margin). The organ where the tumor is growing may also be removed. For instance, this may be an ovary or testicle. […] Chemotherapy. These are strong medicines that kill cancer cells. They may be given by mouth, right into the blood through a vein (IV), or in other ways. […] Radiation therapy. These are high-energy X-rays or other types of radiation. Radiation is used to kill cancer cells or stop them from growing. […] Supportive care. Treatment can cause side effects. Medicines and other treatments can be used for things like pain, fever, infection, and nausea and vomiting. Managing side effects is a key part of good cancer treatment.

• #38 Childhood Germ Cell Tumors | Dana-Farber Cancer Institute

  https://www.dana-farber.org/cancer-care/types/childhood-germ-cell-tumors

  Throughout your child’s treatment, our doctors use supportive care to prevent and treat infections, minimize side effects of treatment, respond to complications, and keep your child comfortable. […] Children with germ cell tumors receive ongoing care in our pediatric cancer survivorship programs. We provide everything from ongoing medical care to psychosocial and nutritional support. Our goal is to support your child’s physical, mental, and emotional health as they grow. […] At Dana-Farber/Boston Children’s, our collaborative team of pediatric cancer doctors comes together to customize each child’s treatment plan.

• #39 Recovery & Support for Germ Cell Tumors | NYU Langone Health

  https://nyulangone.org/conditions/germ-cell-tumors-in-children/support

  At the Stephen D. Hassenfeld Childrens Center for Cancer and Blood Disorders, part of Hassenfeld Childrens Hospital at NYU Langone, pediatric oncologists, surgeons, nurses, and wellness experts care for your child. Our programs can support you and your child throughout treatment and recovery. […] A child who has chemotherapy or surgery for a germ cell tumor may experience fatigue and weakness. After an evaluation by a physician at NYU Langones Rusk Rehabilitation, your child may receive physical and occupational therapy, including strength training, to help increase his or her energy level. […] Wellness programs for children, their siblings, and their parents are offered daily at the Stephen D. Hassenfeld Childrens Center for Cancer and Blood Disorders. These include art therapy, horticulture therapy, massage, music therapy, pet therapy, psychological services, sibling support groups, yoga, and more. Our medical librarians, social workers, and therapists provide your family with support and information during treatment and recovery.

• #40 Germ Cell Tumors – Seattle Children’s

  https://www.seattlechildrens.org/conditions/germ-cell-tumors/

  Most people we treat for cancerous tumors visit Seattle Children’s 1 to 4 times each year for follow-up care. If you live far from Seattle, you may get some lab work like blood and urine tests in your own area. […] Our specialty is treating disease while helping our patients become healthy and productive adults. […] Our team cares for your whole child. As needed, they will receive care from specialists in nutrition, pain management, palliative care, pharmacy, physical therapy and emotional health.

• #41 Germ Cell Tumors (Solid Tumor) Treatment | St. Jude Care & Treatment

  https://www.stjude.org/care-treatment/treatment/childhood-cancer/solid-tumors/germ-cell-tumors-solid-tumor.html

  Germ cell tumors are rare. They are more common in people with certain inherited disorders (passed down through families). They are also more common in males with a history of undescended testicles. […] St. Jude provides the highest quality of care for patients with germ cell tumors: The medical team works closely with lab researchers to bring new treatments from the lab to the clinic. Ongoing research is focused on shortening how long patients receive chemo. The goal is to keep excellent survival rates but reduce the risk of long-term side effects. St. Jude offers a dedicated team of specialists to meet the needs of children with cancer, including: Surgeons, doctors, and nurses who treat this cancer. […] The nurse-to-patient ratio at St. Jude is about 1:3 in hematology and oncology and 1:1 in the Intensive Care Unit.

• #42 Germ Cell Brain Tumor Treatment | St. Jude Care & Treatment

  https://www.stjude.org/care-treatment/treatment/childhood-cancer/brain-tumors/germ-cell-tumors-brain.html

  Most germ cell tumors are treated with chemotherapy along with radiation therapy. […] St. Jude provides the highest quality of care for patients with germ cell tumors: […] We bring together medical experts and specially trained staff to care for your child. […] Our brain tumor clinical trials have led to better therapies in children. […] St. Jude offers a dedicated team of specialists to meet the needs of children with brain tumors, including: […] The nurse-to-patient ratio at St. Jude is about 1:3 in hematology and oncology and 1:1 in the Intensive Care Unit.

• #43 Germ Cell Tumors – Seattle Children’s

  https://www.seattlechildrens.org/conditions/germ-cell-tumors/

  Germ cell tumors can be cancerous (malignant) or not cancerous (benign). […] Even benign germ cell tumors can cause health problems. They may be large and press on other parts of the body. They need treatment. […] Our treatment goal is to give your child the best chance of a long and healthy life. U.S. News World Report consistently ranks our Cancer and Blood Disorders Center among the top pediatric oncology programs in the country. If a tumor affects the reproductive organs, we work to protect the ability to have a baby in the future (fertility preservation). […] Our Solid Tumor team will tailor treatment to your child’s unique needs, based on: Age. Germ cell tumors tend to form differently in young children than in teens or adults. […] Follow-up care is important for 5 years after treatment ends. The follow-up routine will depend on the type of tumor and treatment.

• #44 Germ Cell Tumors in Children | Testicular and Ovarian Tumors in Children | Duke Health

  https://www.dukehealth.org/pediatric-treatments/childhood-cancer/germ-cell-tumors

  Germ cell tumor treatment requires a team of specialists with experience treating children of all ages. Duke Children’s pediatric cancer team provides expert care and a full range of support services tailored to your child’s needs. […] Your doctor will discuss treatment options and match the appropriate treatment to the specific features of each patient’s condition. […] We treat the whole child — not just the disease. Your child receives personalized treatment and follow-up plans tailored to their needs. […] Our team focuses on managing your child’s symptoms and other aspects of treatment that affect your child’s quality of life. […] Our Teen and Young Adult Oncology Program brings together the expertise of pediatric and adult cancer specialists to determine what’s best for each person, along with personalized psychological support.

• #45 What are Childhood Germ Cell Tumors? Symptoms, Risk Factors & Treatments | MD Anderson Cancer Center

  https://www.mdanderson.org/cancer-types/childhood-germ-cell-tumors.html

  At MD Anderson’s Children’s Cancer Hospital, we know your child’s health and well being are your number one concern. Our renowned experts customize your child’s care for childhood germ cell tumors, utilizing the most advanced treatments and techniques with the least impact on your child’s growing body. As part of one of the world’s most active cancer centers, Children’s Cancer Hospital has remarkable experience and skill in these types of cancer. This can make a difference in your child’s outcome. […] A team of specially trained physicians follows your child throughout treatment, all the way to survivorship. They communicate closely with each other, and with you, to ensure comprehensive, personalized care. They are supported by full complement of health care professionals dedicated to your child’s treatment, including nurses, physician assistants, therapists and others. […] Children’s Cancer Hospital is designed just for children, with a full range of services and amenities that help make the child and family’s experience as comfortable as possible. We go beyond medical care to deliver a comprehensive experience that treats the whole child.

• #46 Germ Cell Tumor Program | Children’s Healthcare of Atlanta

  https://www.choa.org/medical-services/cancer-and-blood-disorders/cancer/germ-cell-tumor-program

  Receiving a cancer diagnosis for your child can be an emotional and overwhelming experience. At the Aflac Cancer and Blood Disorders Center, we are here to support you and your family. We make it our mission to provide the best care and best experience for every child, whether treating a toddler during an emergency or helping a teen through chemotherapy treatments. Family plays an important role in your child’s well-being. Not only are you a vital part of your child’s healthcare team; you are a source of security and comfort. […] We work to support your whole family while your child is in our care and after she goes home.

• #47 Germ Cell Tumor Program | Children’s Healthcare of Atlanta

  https://www.choa.org/medical-services/cancer-and-blood-disorders/cancer/germ-cell-tumor-program

  Receiving a cancer diagnosis for your child can be an emotional and overwhelming experience. At the Aflac Cancer and Blood Disorders Center, we are here to support you and your family. We make it our mission to provide the best care and best experience for every child, whether treating a toddler during an emergency or helping a teen through chemotherapy treatments. Family plays an important role in your child’s well-being. Not only are you a vital part of your child’s healthcare team; you are a source of security and comfort. […] We work to support your whole family while your child is in our care and after she goes home.

• #48 Germ Cell Tumors (GCTs) in Children | Cedars-Sinai

  https://www.cedars-sinai.org/health-library/diseases-and-conditions—pediatrics/g/germ-cell-tumors-in-children.html

  A child with a germ cell tumor needs ongoing care. Your child will be seen by oncologists and other healthcare providers to treat any late effects of treatment and to watch for signs or symptoms of the tumor returning. […] You can help your child manage their treatment in many ways. For example: […] Make sure your child attends all follow-up appointments. […] Talk with your child’s healthcare providers about side effects linked with your child’s treatment. There are often ways to manage them. There may be things you can do and medicines you can give your child to help prevent or control many treatment side effects.

• #49 Germ Cell Tumors (GCTs) in Children

  https://www.nationwidechildrens.org/conditions/health-library/germ-cell-tumors-gcts-in-children

  Talk with your child’s healthcare providers about side effects linked with your child’s treatment. There are often ways to manage them. There may be things you can do and medicines you can give your child to help prevent or control many treatment side effects. […] A child with a germ cell tumor needs ongoing care. Your child will be seen by oncologists and other healthcare providers to treat any late effects of treatment and to watch for signs or symptoms of the tumor returning. […] You can help your child manage their treatment in many ways. For example: […] Make sure your child attends all follow-up appointments. […] Call the healthcare provider if your child has: […] Symptoms that get worse […] New symptoms […] Side effects that don’t get better with treatment.

• #50 What are Childhood Germ Cell Tumors? Symptoms, Risk Factors & Treatments | MD Anderson Cancer Center

  https://www.mdanderson.org/cancer-types/childhood-germ-cell-tumors.html

  At MD Anderson’s Children’s Cancer Hospital, we know your child’s health and well being are your number one concern. Our renowned experts customize your child’s care for childhood germ cell tumors, utilizing the most advanced treatments and techniques with the least impact on your child’s growing body. As part of one of the world’s most active cancer centers, Children’s Cancer Hospital has remarkable experience and skill in these types of cancer. This can make a difference in your child’s outcome. […] A team of specially trained physicians follows your child throughout treatment, all the way to survivorship. They communicate closely with each other, and with you, to ensure comprehensive, personalized care. They are supported by full complement of health care professionals dedicated to your child’s treatment, including nurses, physician assistants, therapists and others. […] Children’s Cancer Hospital is designed just for children, with a full range of services and amenities that help make the child and family’s experience as comfortable as possible. We go beyond medical care to deliver a comprehensive experience that treats the whole child.

• #51 Recovery & Support for Germ Cell Tumors | NYU Langone Health

  https://nyulangone.org/conditions/germ-cell-tumors-in-children/support

  At the Stephen D. Hassenfeld Childrens Center for Cancer and Blood Disorders, part of Hassenfeld Childrens Hospital at NYU Langone, pediatric oncologists, surgeons, nurses, and wellness experts care for your child. Our programs can support you and your child throughout treatment and recovery. […] A child who has chemotherapy or surgery for a germ cell tumor may experience fatigue and weakness. After an evaluation by a physician at NYU Langones Rusk Rehabilitation, your child may receive physical and occupational therapy, including strength training, to help increase his or her energy level. […] Wellness programs for children, their siblings, and their parents are offered daily at the Stephen D. Hassenfeld Childrens Center for Cancer and Blood Disorders. These include art therapy, horticulture therapy, massage, music therapy, pet therapy, psychological services, sibling support groups, yoga, and more. Our medical librarians, social workers, and therapists provide your family with support and information during treatment and recovery.

• #52 Pharmacotherapeutic treatment of germ cell tumors: standard of care and recent developments – PubMed

  https://pubmed.ncbi.nlm.nih.gov/26630452/

  Testicular germ cell tumors are the most common malignancy among men aged 40 and less. […] Since the introduction of cisplatin-based combination chemotherapy, germ cell tumors are among the most curable solid tumors with cure rates of 95% in all patients and 80% in metastatic disease. […] Maintaining therapeutic success while further reducing treatment-related toxicity is paramount. […] Cancer-specific survival in localized disease approximates 100%. […] Therefore, orchidectomy followed by active surveillance is the preferred approach for all seminomas and non-seminomas lacking lymphovascular invasion. […] Non-seminomas with lymphovascular invasion should be offered adjuvant treatment with one cycle of bleomycin, etoposide and cisplatin (BEP). […] The BEP regimen remains standard of care for metastatic disease, while the role of primary high-dose chemotherapy in case of inadequate tumor-marker decline or presence of high-risk features (i.e. mediastinal origin, non-pulmonary visceral metastases) remains to be elucidated. […] Several curative salvage chemotherapy combinations are available, i.e. TIP, VeIP, GIP or high-dose carboplatin and etoposide. […] GOP is the current option of choice in cisplatin-refractory patients. […] Novel targeted agents failed to improve treatment outcome so far.

• #53 Germ Cell Tumors (GCTs) in Children | Cedars-Sinai

  https://www.cedars-sinai.org/health-library/diseases-and-conditions—pediatrics/g/germ-cell-tumors-in-children.html

  A child with a germ cell tumor needs ongoing care. Your child will be seen by oncologists and other healthcare providers to treat any late effects of treatment and to watch for signs or symptoms of the tumor returning. […] You can help your child manage their treatment in many ways. For example: […] Make sure your child attends all follow-up appointments. […] Talk with your child’s healthcare providers about side effects linked with your child’s treatment. There are often ways to manage them. There may be things you can do and medicines you can give your child to help prevent or control many treatment side effects.

• #54 Germ Cell Tumors (GCTs) in Children

  https://www.nationwidechildrens.org/conditions/health-library/germ-cell-tumors-gcts-in-children

  Talk with your child’s healthcare providers about side effects linked with your child’s treatment. There are often ways to manage them. There may be things you can do and medicines you can give your child to help prevent or control many treatment side effects. […] A child with a germ cell tumor needs ongoing care. Your child will be seen by oncologists and other healthcare providers to treat any late effects of treatment and to watch for signs or symptoms of the tumor returning. […] You can help your child manage their treatment in many ways. For example: […] Make sure your child attends all follow-up appointments. […] Call the healthcare provider if your child has: […] Symptoms that get worse […] New symptoms […] Side effects that don’t get better with treatment.

• #55 Germ Cell Tumors – Seattle Children’s

  https://www.seattlechildrens.org/conditions/germ-cell-tumors/

  Germ cell tumors can be cancerous (malignant) or not cancerous (benign). […] Even benign germ cell tumors can cause health problems. They may be large and press on other parts of the body. They need treatment. […] Our treatment goal is to give your child the best chance of a long and healthy life. U.S. News World Report consistently ranks our Cancer and Blood Disorders Center among the top pediatric oncology programs in the country. If a tumor affects the reproductive organs, we work to protect the ability to have a baby in the future (fertility preservation). […] Our Solid Tumor team will tailor treatment to your child’s unique needs, based on: Age. Germ cell tumors tend to form differently in young children than in teens or adults. […] Follow-up care is important for 5 years after treatment ends. The follow-up routine will depend on the type of tumor and treatment.

• #56 Germ Cell Tumors | Boston Children’s Hospital

  https://www.childrenshospital.org/conditions/germ-cell-tumors

  Children treated for a malignant germ cell tumor should visit a cancer survivorship clinic every year to manage disease complications, screen for recurrence, and manage late treatment side effects. A typical follow-up visit is likely to include a physical exam, laboratory testing, and imaging scans.

• #57 Germ Cell Tumors of the Brain | Boston Children’s Hospital

  https://www.childrenshospital.org/conditions/germ-cell-brain-tumors

  Your child’s physician will determine a specific course of treatment based on several factors, including your child’s age, overall health and medical history, the type, location, and size of the tumor and the extent of the disease. Treatments for germ cell brain tumors include: Neurosurgery, Endoscopic third ventriculostomy or ventriculo-peritoneal shunt, Radiation therapy, Chemotherapy. […] Children treated for a germ cell tumor in the brain should visit a survivorship clinic every year to manage disease complications, screen for recurrence and manage late treatment side effects. A typical follow-up visit is likely to include a physical exam, laboratory testing, and imaging scans.

• #58 Germinoma | UCSF Brain Tumor Center

  https://braintumorcenter.ucsf.edu/condition/germinoma

  Although radiation can be curative for many patients, some survivors are at risk for developing long-term side effects. Especially for pediatric patients, radiation and chemotherapy may increase risk of learning disabilities, hearing loss, fertility issues, or secondary cancers (like leukemia) that can develop later in life. However, your doctors will discuss how these risks apply to your or your childs personalized treatment plan. Ongoing research at UCSF aims to identify more effective treatment strategies with fewer long-term complications to the patient. […] Supportive Care.

• #59 Childhood Germ Cell Tumors | Dana-Farber Cancer Institute

  https://www.dana-farber.org/cancer-care/types/childhood-germ-cell-tumors

  Throughout your child’s treatment, our doctors use supportive care to prevent and treat infections, minimize side effects of treatment, respond to complications, and keep your child comfortable. […] Children with germ cell tumors receive ongoing care in our pediatric cancer survivorship programs. We provide everything from ongoing medical care to psychosocial and nutritional support. Our goal is to support your child’s physical, mental, and emotional health as they grow. […] At Dana-Farber/Boston Children’s, our collaborative team of pediatric cancer doctors comes together to customize each child’s treatment plan.

• #60 Childhood Germ Cell Tumor of the Brain | Dana-Farber Cancer Institute

  https://www.dana-farber.org/cancer-care/types/childhood-germ-cell-tumor-of-the-brain

  Children with germ cell tumors of the brain receive ongoing care in our pediatric cancer survivorship programs, including the Stop Shop Family Pediatric Neuro-Oncology Outcomes Clinic for pediatric brain tumor survivors. We provide everything from ongoing medical care to psychosocial and nutritional support. Our goal is to support your child’s physical, mental, and emotional health as they grow. […] At Dana-Farber/Boston Children’s, our team of brain tumor specialists includes neuro-oncologists, neurosurgeons, and neurologists.

• #61 Germ Cell Tumors | Lurie Children’s

  https://www.luriechildrens.org/en/specialties-conditions/germ-cell-tumors/

  Treatment may include (alone or in combination): Surgery (to remove tumor and involved organs), Chemotherapy, Radiation (not usually used), Bone marrow transplantation (not usually used; typically used if tumors recur or don’t respond to standard treatment), Supportive care (for the effects of treatment), Hormonal replacement (if necessary), Antibiotics (to prevent/treat infections), Continuous follow-up care (to determine response to treatment, detect recurrent disease and manage the late effects of treatment). […] Continuous follow-up care is essential for a child diagnosed with a germ cell tumor. Side effects of radiation and chemotherapy, as well as second malignancies, can occur in survivors of germ cell tumors. New methods are continually being discovered to improve treatment and to decrease side effects.

• #62 Recovery & Support for Germ Cell Tumors | NYU Langone Health

  https://nyulangone.org/conditions/germ-cell-tumors-in-children/support

  At the Stephen D. Hassenfeld Childrens Center for Cancer and Blood Disorders, part of Hassenfeld Childrens Hospital at NYU Langone, pediatric oncologists, surgeons, nurses, and wellness experts care for your child. Our programs can support you and your child throughout treatment and recovery. […] A child who has chemotherapy or surgery for a germ cell tumor may experience fatigue and weakness. After an evaluation by a physician at NYU Langones Rusk Rehabilitation, your child may receive physical and occupational therapy, including strength training, to help increase his or her energy level. […] Wellness programs for children, their siblings, and their parents are offered daily at the Stephen D. Hassenfeld Childrens Center for Cancer and Blood Disorders. These include art therapy, horticulture therapy, massage, music therapy, pet therapy, psychological services, sibling support groups, yoga, and more. Our medical librarians, social workers, and therapists provide your family with support and information during treatment and recovery.

• #63 Get Germ Cell Tumor Treatment | Cleveland Clinic Children’s

  https://my.clevelandclinic.org/pediatrics/services/germ-cell-tumor-treatment

  For cancerous germ cell tumors, your childs provider may also recommend radiation therapy, which sends high energy X-rays to the cancer cells to destroy them. For some kinds of germ cell tumors, radiation therapy is the best treatment. […] Our follow-up care starts with helping your child recover after surgery, but it doesnt stop there. Well care for your child long after theyve finished treatment. Your child will continue to visit their providers regularly to see how theyre doing and to check their overall health. Well also do tests to make sure a germ cell tumor hasnt come back or there arent any signs of new health conditions that may develop after treatment. […] If your child has a germ cell tumor, youll want to work with pediatric healthcare providers who specialize in treating rare conditions. And youll want compassionate providers who understand how children and teens react to having a serious illness. Youll find that combination of expertise and compassion at Cleveland Clinic Childrens. Well develop personalized care plans that also include support for your child and you as you manage their illness and any long-term challenges.

• #64 Testicular Cancer Program | UC San Diego Health

  https://health.ucsd.edu/care/cancer/cancers-we-treat/testicular/

  This unique clinic focuses on improving the prognosis and quality of life for people with high-risk, aggressive or metastatic genitourinary cancers such as testicular cancer. […] At UC San Diego Health, your cancer care is led by a team of doctors who specialize in your type of cancer. Highly specialized multidisciplinary care is a hallmark of top-tier academic medical centers such as UC San Diego Health. […] UC San Diego Health physicians are actively researching ways to improve cancer care. […] At UC San Diego Health, your care goes beyond treating disease. It also includes supporting you and your loved ones emotionally throughout your cancer journey.

• #65 Testicular Cancer (Germ Cell Tumors) | Memorial Sloan Kettering Cancer Center

  https://www.mskcc.org/cancer-care/types/testicular-germ-cell-tumors

  Medical oncologist Darren Feldman and the rest of Memorial Sloan Kettering’s testicular cancer team offer expert care and the latest treatment options. […] This guide has information about how to support a loved one who has cancer, even if theyre not an MSK patient. At MSK, supporting caregivers is as important as caring for people with cancer. […] Our specialists work as a team to plan the best treatment for you. For early-stage tumors, this often includes surgery. You also may have chemotherapy if the tumor is more advanced. […] MSK has many resources for people living with testicular cancer. We offer guidance on male sexual health and options for preserving fertility and building a family. We also support long-term survivorship after your treatment.

• #66 Nursing Care Plan (NCP) for Testicular Cancer | Free NURSING.com Courses

  https://nursing.com/lesson/nursing-care-plan-ncp-for-testicular-cancer

  To equip nursing professionals with a comprehensive framework for managing patients with testicular cancer. The plan focuses on understanding the diseases pathophysiology, recognizing its symptoms, and implementing effective nursing interventions for symptom management, complication prevention, and emotional support. […] This care plan is dedicated to providing holistic management for patients with testicular cancer, focusing on symptom relief, emotional support, patient education, and addressing concerns about fertility and body image. Customizing care to individual patient needs and concerns is crucial for effective management and improved quality of life.

• #67 Germ Cell Tumors (GCTs) in Children | Cedars-Sinai

  https://www.cedars-sinai.org/health-library/diseases-and-conditions—pediatrics/g/germ-cell-tumors-in-children.html

  Germ cell tumors (GCTs) are made up of these underdeveloped cells. These tumors are rare. They may be cancer (malignant) or not cancer (benign). […] GCTs can be treated with any of these: […] Surgery. This is done to take out the tumor and an edge of nearby normal tissue (surgical margin). The organ where the tumor is growing may also be removed. For instance, this may be an ovary or testicle. […] Chemotherapy. These are strong medicines that kill cancer cells. They may be given by mouth, right into the blood through a vein (IV), or in other ways. […] Radiation therapy. These are high-energy X-rays or other types of radiation. Radiation is used to kill cancer cells or stop them from growing. […] Supportive care. Treatment can cause side effects. Medicines and other treatments can be used for things like pain, fever, infection, and nausea and vomiting. Managing side effects is a key part of good cancer treatment.

• #68 Germ Cell Tumors (GCTs) in Children

  https://www.nationwidechildrens.org/conditions/health-library/germ-cell-tumors-gcts-in-children

  Germ cell tumors (GCTs) are made up of these underdeveloped cells. […] GCTs can be treated with any of these: […] Surgery. This is done to take out the tumor and an edge of nearby normal tissue (surgical margin). The organ where the tumor is growing may also be removed. For instance, this may be an ovary or testicle. […] Chemotherapy. These are strong medicines that kill cancer cells. They may be given by mouth, right into the blood through a vein (IV), or in other ways. […] Radiation therapy. These are high-energy X-rays or other types of radiation. Radiation is used to kill cancer cells or stop them from growing. […] Supportive care. Treatment can cause side effects. Medicines and other treatments can be used for things like pain, fever, infection, and nausea and vomiting. Managing side effects is a key part of good cancer treatment.

• #69 Germ Cell Tumors (GCTs) in Children | Phoenix Children’s Hospital

  https://phoenixchildrens.org/specialties-conditions/germ-cell-tumors-gcts-children

  Germ cell tumors (GCTs) are made up of these underdeveloped cells. These tumors are rare. They may be cancer (malignant) or not cancer (benign). […] GCTs can be treated with any of these: […] Surgery. This is done to take out the tumor and an edge of nearby normal tissue (surgical margin). The organ where the tumor is growing may also be removed. For instance, this may be an ovary or testicle. […] Chemotherapy. These are strong medicines that kill cancer cells. They may be given by mouth, right into the blood through a vein (IV), or in other ways. […] Radiation therapy. These are high-energy X-rays or other types of radiation. Radiation is used to kill cancer cells or stop them from growing. […] Supportive care. Treatment can cause side effects. Medicines and other treatments can be used for things like pain, fever, infection, and nausea and vomiting. Managing side effects is a key part of good cancer treatment.

• #70 Germ Cell Tumors (GCTs) in Children

  https://www.nationwidechildrens.org/conditions/health-library/germ-cell-tumors-gcts-in-children

  Talk with your child’s healthcare providers about side effects linked with your child’s treatment. There are often ways to manage them. There may be things you can do and medicines you can give your child to help prevent or control many treatment side effects. […] A child with a germ cell tumor needs ongoing care. Your child will be seen by oncologists and other healthcare providers to treat any late effects of treatment and to watch for signs or symptoms of the tumor returning. […] You can help your child manage their treatment in many ways. For example: […] Make sure your child attends all follow-up appointments. […] Call the healthcare provider if your child has: […] Symptoms that get worse […] New symptoms […] Side effects that don’t get better with treatment.

• #71 Germ Cell Tumors (GCTs) in Children | Phoenix Children’s Hospital

  https://phoenixchildrens.org/specialties-conditions/germ-cell-tumors-gcts-children

  Talk with your child’s healthcare providers about side effects linked with your child’s treatment. There are often ways to manage them. There may be things you can do and medicines you can give your child to help prevent or control many treatment side effects. […] A child with a germ cell tumor needs ongoing care. Your child will be seen by oncologists and other healthcare providers to treat any late effects of treatment and to watch for signs or symptoms of the tumor returning. […] You can help your child manage their treatment in many ways. For example: […] Make sure your child attends all follow-up appointments. […] Call the healthcare provider if your child has: […] Side effects that don’t get better with treatment. […] Treatment may include surgery, chemotherapy, and radiation therapy.

• #72 What are germ cell tumours? | Cancer Research UK

  https://www.cancerresearchuk.org/about-cancer/germ-cell-tumours

  Your treatment depends on your type of germ cell tumour and whereabouts it is in your body. […] The main treatments are surgery and chemotherapy. […] You usually have surgery to remove germ cell tumours. This might be all the treatment you need if the tumour is small and easy to remove. […] You might have chemotherapy after surgery. Germ cell tumours generally respond very well to chemotherapy. Most people are cured. Even cancers that have spread are still very treatable with chemotherapy. […] Coping with a diagnosis of a rare cancer can be especially difficult. Being well informed about your cancer and its treatment can help. It can make it easier to make decisions and cope with what happens. […] You can call our nurse freephone helpline on 0808 800 4040. They are available from Monday to Friday, 9am to 5pm. Or you can send them a question online. […] The Rare Cancer Alliance offer support and information to people with rare cancers. It has a forum where you might be able to meet others with the same cancer as you.

• #73 Germ Cell Tumors (GCTs) in Children | Cedars-Sinai

  https://www.cedars-sinai.org/health-library/diseases-and-conditions—pediatrics/g/germ-cell-tumors-in-children.html

  A child with a germ cell tumor needs ongoing care. Your child will be seen by oncologists and other healthcare providers to treat any late effects of treatment and to watch for signs or symptoms of the tumor returning. […] You can help your child manage their treatment in many ways. For example: […] Make sure your child attends all follow-up appointments. […] Talk with your child’s healthcare providers about side effects linked with your child’s treatment. There are often ways to manage them. There may be things you can do and medicines you can give your child to help prevent or control many treatment side effects.

• #74 Germ Cell Tumors (GCTs) in Children | Phoenix Children’s Hospital

  https://phoenixchildrens.org/specialties-conditions/germ-cell-tumors-gcts-children

  Talk with your child’s healthcare providers about side effects linked with your child’s treatment. There are often ways to manage them. There may be things you can do and medicines you can give your child to help prevent or control many treatment side effects. […] A child with a germ cell tumor needs ongoing care. Your child will be seen by oncologists and other healthcare providers to treat any late effects of treatment and to watch for signs or symptoms of the tumor returning. […] You can help your child manage their treatment in many ways. For example: […] Make sure your child attends all follow-up appointments. […] Call the healthcare provider if your child has: […] Side effects that don’t get better with treatment. […] Treatment may include surgery, chemotherapy, and radiation therapy.

• #75 Germ Cell Tumors (GCTs) in Children

  http://healthlibrary.chnola.org/Search/90,P02725

  A child with a germ cell tumor needs ongoing care. Your child will be seen by oncologists and other healthcare providers to treat any late effects of treatment and to watch for signs or symptoms of the tumor returning. […] You can help your child manage their treatment in many ways. For example: Your child may have trouble eating. A dietitian may be able to help. […] Make sure your child attends all follow-up appointments. […] Talk with your child’s healthcare providers about treatment choices. Make a list of questions. Think about the benefits and possible side effects of each choice. Talk about your concerns with your healthcare provider before making a decision.

• #76 Germ Cell Tumor Program | Children’s Healthcare of Atlanta

  https://www.choa.org/medical-services/cancer-and-blood-disorders/cancer/germ-cell-tumor-program

  Receiving a cancer diagnosis for your child can be an emotional and overwhelming experience. At the Aflac Cancer and Blood Disorders Center, we are here to support you and your family. We make it our mission to provide the best care and best experience for every child, whether treating a toddler during an emergency or helping a teen through chemotherapy treatments. Family plays an important role in your child’s well-being. Not only are you a vital part of your child’s healthcare team; you are a source of security and comfort. […] We work to support your whole family while your child is in our care and after she goes home.

• #77 Nursing Care Plan (NCP) for Testicular Cancer | Free NURSING.com Courses

  https://nursing.com/lesson/nursing-care-plan-ncp-for-testicular-cancer

  To equip nursing professionals with a comprehensive framework for managing patients with testicular cancer. The plan focuses on understanding the diseases pathophysiology, recognizing its symptoms, and implementing effective nursing interventions for symptom management, complication prevention, and emotional support. […] This care plan is dedicated to providing holistic management for patients with testicular cancer, focusing on symptom relief, emotional support, patient education, and addressing concerns about fertility and body image. Customizing care to individual patient needs and concerns is crucial for effective management and improved quality of life.

• #78 Recovery & Support for Germ Cell Tumors | NYU Langone Health

  https://nyulangone.org/conditions/germ-cell-tumors-in-children/support

  At the Stephen D. Hassenfeld Childrens Center for Cancer and Blood Disorders, part of Hassenfeld Childrens Hospital at NYU Langone, pediatric oncologists, surgeons, nurses, and wellness experts care for your child. Our programs can support you and your child throughout treatment and recovery. […] A child who has chemotherapy or surgery for a germ cell tumor may experience fatigue and weakness. After an evaluation by a physician at NYU Langones Rusk Rehabilitation, your child may receive physical and occupational therapy, including strength training, to help increase his or her energy level. […] Wellness programs for children, their siblings, and their parents are offered daily at the Stephen D. Hassenfeld Childrens Center for Cancer and Blood Disorders. These include art therapy, horticulture therapy, massage, music therapy, pet therapy, psychological services, sibling support groups, yoga, and more. Our medical librarians, social workers, and therapists provide your family with support and information during treatment and recovery.

• #79 Germ Cell Tumors (Solid Tumor) Treatment | St. Jude Care & Treatment

  https://www.stjude.org/care-treatment/treatment/childhood-cancer/solid-tumors/germ-cell-tumors-solid-tumor.html

  Germ cell tumors are rare. They are more common in people with certain inherited disorders (passed down through families). They are also more common in males with a history of undescended testicles. […] St. Jude provides the highest quality of care for patients with germ cell tumors: The medical team works closely with lab researchers to bring new treatments from the lab to the clinic. Ongoing research is focused on shortening how long patients receive chemo. The goal is to keep excellent survival rates but reduce the risk of long-term side effects. St. Jude offers a dedicated team of specialists to meet the needs of children with cancer, including: Surgeons, doctors, and nurses who treat this cancer. […] The nurse-to-patient ratio at St. Jude is about 1:3 in hematology and oncology and 1:1 in the Intensive Care Unit.

• #80 Germ Cell Tumors | Conditions | UCSF Benioff Children’s Hospitals

  https://www.ucsfbenioffchildrens.org/conditions/germ-cell-tumors

  Where to get care […] Your child’s treatment options will depend on the type of germ cell tumor, its location and whether the disease has spread to other parts of the body. In some cases, it’s possible to perform surgery to remove the tumor completely. […] Some germ cell tumors can be treated with radiation therapy either alone or in combination with surgery. Radiation therapy uses high-dose X-rays or other radiation sources to kill cancer cells. […] Chemotherapy is effective for malignant germ cell tumors and almost always used in combination with surgery. It may be given before surgery to shrink a large tumor (making it easier to remove) or after surgery to kill any cancer cells left behind. […] Your child may be able to receive promising experimental treatments by participating in a clinical trial.

• #81 Central Nervous System Germ Cell Tumors Treatment | NY | Montefiore Einstein Comprehensive Cancer Center

  https://montefioreeinstein.org/cancer/types/childhood/central-nervous-system-germ-cell-tumors-treatment

  Children with CNS germ cell tumors should have their treatment planned by a team of health care providers who are experts in treating cancer in children. […] The following types of treatment are used: Radiation therapy, Chemotherapy, Surgery, High-dose chemotherapy with stem cell rescue. […] Treatment for childhood CNS germ cell tumors may cause side effects. […] Patients may want to think about taking part in a clinical trial. […] Follow-up care may be needed.

• #82 Ovarian and testicular germ cell cancer | Imperial College Healthcare Private Care

  https://www.private.imperial.nhs.uk/services/cancer-care/cancer-types/germ-cell-cancer

  Once you are referred to us, we will carry out an urgent review of your blood tests, tissue samples and scans to determine treatment. This depends on the site and type of germ cell tumour and usually involves a combination of surgery to remove the tumour and chemotherapy to destroy any remaining cancer cells. […] You may be offered a combination of drugs followed by regular scans to ensure the cancer has not returned. We also have the expertise to deliver treatment which preserves your fertility as much as possible. […] Our expert clinicians are involved in the latest research so you will have access to up-to-date treatments and the best approaches to treating your cancer. […] We have pioneered the use of high-dose chemotherapy to beat the disease in patients who no longer respond to standard therapies, and we have also pioneered developments in monitoring disease which has spared many patients from the need for chemotherapy. Our team is also pioneering fertility preservation.

• #83 Nursing Care Plan (NCP) for Testicular Cancer | Free NURSING.com Courses

  https://nursing.com/lesson/nursing-care-plan-ncp-for-testicular-cancer

  To equip nursing professionals with a comprehensive framework for managing patients with testicular cancer. The plan focuses on understanding the diseases pathophysiology, recognizing its symptoms, and implementing effective nursing interventions for symptom management, complication prevention, and emotional support. […] This care plan is dedicated to providing holistic management for patients with testicular cancer, focusing on symptom relief, emotional support, patient education, and addressing concerns about fertility and body image. Customizing care to individual patient needs and concerns is crucial for effective management and improved quality of life.

• #84 Pharmacotherapeutic treatment of germ cell tumors: standard of care and recent developments – PubMed

  https://pubmed.ncbi.nlm.nih.gov/26630452/

  Testicular germ cell tumors are the most common malignancy among men aged 40 and less. […] Since the introduction of cisplatin-based combination chemotherapy, germ cell tumors are among the most curable solid tumors with cure rates of 95% in all patients and 80% in metastatic disease. […] Maintaining therapeutic success while further reducing treatment-related toxicity is paramount. […] Cancer-specific survival in localized disease approximates 100%. […] Therefore, orchidectomy followed by active surveillance is the preferred approach for all seminomas and non-seminomas lacking lymphovascular invasion. […] Non-seminomas with lymphovascular invasion should be offered adjuvant treatment with one cycle of bleomycin, etoposide and cisplatin (BEP). […] The BEP regimen remains standard of care for metastatic disease, while the role of primary high-dose chemotherapy in case of inadequate tumor-marker decline or presence of high-risk features (i.e. mediastinal origin, non-pulmonary visceral metastases) remains to be elucidated. […] Several curative salvage chemotherapy combinations are available, i.e. TIP, VeIP, GIP or high-dose carboplatin and etoposide. […] GOP is the current option of choice in cisplatin-refractory patients. […] Novel targeted agents failed to improve treatment outcome so far.

• #85 Germ cell tumours | The Royal Marsden

  https://www.royalmarsden.nhs.uk/your-care/cancer-types/paediatric-cancers/germ-cell-tumours

  The treatment for germ cell tumours depends on the size, position and stage of the tumour. This usually involves surgery and sometimes chemotherapy (anti-cancer therapy). […] If the tumour is benign and can be removed completely then no further treatment is needed. If the tumour is malignant and can be removed completely then chemotherapy may still be needed if the tumour is large or there are some cancer cells left behind. In all other situations chemotherapy and possible further surgery will be needed. […] The prognosis is good for germ cell tumours. Most children are cured. […] The doctors and nurses caring for your child will tell you more about these side effects. […] About five years after treatment finishes we will transfer your child’s care to our long term follow-up clinic. Your child will be seen at regular intervals in this clinic, indefinitely, so that we can help with any long term effects of the treatment.

• #86 Nursing Care Plan (NCP) for Testicular Cancer | Free NURSING.com Courses

  https://nursing.com/lesson/nursing-care-plan-ncp-for-testicular-cancer

  To equip nursing professionals with a comprehensive framework for managing patients with testicular cancer. The plan focuses on understanding the diseases pathophysiology, recognizing its symptoms, and implementing effective nursing interventions for symptom management, complication prevention, and emotional support. […] This care plan is dedicated to providing holistic management for patients with testicular cancer, focusing on symptom relief, emotional support, patient education, and addressing concerns about fertility and body image. Customizing care to individual patient needs and concerns is crucial for effective management and improved quality of life.

• #87 Germ Cell Tumors (Solid Tumor) Treatment | St. Jude Care & Treatment

  https://www.stjude.org/care-treatment/treatment/childhood-cancer/solid-tumors/germ-cell-tumors-solid-tumor.html

  Germ cell tumors are rare. They are more common in people with certain inherited disorders (passed down through families). They are also more common in males with a history of undescended testicles. […] St. Jude provides the highest quality of care for patients with germ cell tumors: The medical team works closely with lab researchers to bring new treatments from the lab to the clinic. Ongoing research is focused on shortening how long patients receive chemo. The goal is to keep excellent survival rates but reduce the risk of long-term side effects. St. Jude offers a dedicated team of specialists to meet the needs of children with cancer, including: Surgeons, doctors, and nurses who treat this cancer. […] The nurse-to-patient ratio at St. Jude is about 1:3 in hematology and oncology and 1:1 in the Intensive Care Unit.

• #88 Ovarian and testicular germ cell cancer | Imperial College Healthcare Private Care

  https://www.private.imperial.nhs.uk/services/cancer-care/cancer-types/germ-cell-cancer

  Once you are referred to us, we will carry out an urgent review of your blood tests, tissue samples and scans to determine treatment. This depends on the site and type of germ cell tumour and usually involves a combination of surgery to remove the tumour and chemotherapy to destroy any remaining cancer cells. […] You may be offered a combination of drugs followed by regular scans to ensure the cancer has not returned. We also have the expertise to deliver treatment which preserves your fertility as much as possible. […] Our expert clinicians are involved in the latest research so you will have access to up-to-date treatments and the best approaches to treating your cancer. […] We have pioneered the use of high-dose chemotherapy to beat the disease in patients who no longer respond to standard therapies, and we have also pioneered developments in monitoring disease which has spared many patients from the need for chemotherapy. Our team is also pioneering fertility preservation.

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