Materiały źródłowe

• #1

  https://link.springer.com/article/10.1007/s12035-014-8689-6

  Parkinsons disease (PD) is a chronic neurodegenerative movement disorder characterized by the progressive and massive loss of dopaminergic neurons by neuronal apoptosis in the substantia nigra pars compacta and depletion of dopamine in the striatum, which lead to pathological and clinical abnormalities. […] A further understanding of the cellular and molecular mechanisms involved in the pathophysiology of PD is crucial for developing effective diagnostic, preventative, and therapeutic strategies to cure this devastating disorder. […] Multiple lines of evidence have demonstrated that preconditioning as a possible neuroprotective technique may reduce the neural deficits associated with neurodegenerative diseases such as PD. […] In this review, we will summarize pathophysiology and current therapeutic approaches in PD and discuss about preconditioning in PD as a potential neuroprotective strategy. […] Preconditioning may represent a promising therapeutic weapon to combat neurodegeneration.

• #2 Parkinson’s Disease: Symptoms & Causes | NewYork-Presbyterian

  https://www.nyp.org/neuro/parkinsons-disease-movement-disorders/parkinsons-disease

  Because the cause of Parkinsons is unknown, there are no proven ways to prevent the disease.

• #3 Exercise as medicine in Parkinson’s disease | Journal of Neurology, Neurosurgery & Psychiatry

  https://jnnp.bmj.com/content/95/11/1077

  Parkinsons disease (PD) is an incurable and progressive neurological disorder leading to deleterious motor and non-motor consequences. […] Identification of interventions that prevent, slow, halt or mitigate the disease is therefore pivotal. Exercise is safe and represents a cornerstone in PD rehabilitation, but exercise may have even more fundamental benefits that could change clinical practice. In PD, the existing knowledge base supports exercise as (1) a protective lifestyle factor preventing the disease (ie, primary prevention), (2) a potential disease-modifying therapy (ie, secondary prevention) and (3) an effective symptomatic treatment (ie, tertiary prevention). […] Today there is no approved treatment that prevents the development of PD or stops or slows PD progression, and the currently available pharmacological symptomatic treatments are not effective for several symptoms, often reduce their effectiveness over time and cause side effects.

• #4 Exercise as medicine in Parkinson’s disease | Journal of Neurology, Neurosurgery & Psychiatry

  https://jnnp.bmj.com/content/95/11/1077

  The identification of safe and effective symptomatic treatments (attenuating symptoms of the disease, ie, tertiary prevention), disease-modifying treatments (decreasing the severity of PD or slowing/halting progression of the disease by affecting the underlying pathology/pathophysiology, ie, secondary prevention) and potentially even preventive treatments (preventing disease development or stopping individuals from becoming at high risk, i.e, primary prevention) is therefore highly needed in PD. […] One of the most promising interventions is exercise with recent reviews showing beneficial effects on several PD symptoms and relevant clinical severity markers. […] While early studies emphasised exercise as an interesting symptomatic treatment (ie, tertiary prevention), more recent studies have also proposed exercise as being potentially disease-modifying by slowing disease progression (ie, secondary prevention) and even reducing the risk of getting PD (ie, primary prevention).

• #5

  https://www.movementdisorders.org/Moving-Along/2023-issue-3/Using-precision-medicine-Parkinsons-disease-prevention.htm

  We are starting to unravel how a persons unique biology could affect their treatment. […] In this lecture, I will apply a combination of public health and precision medicine principles to Parkinsons disease (PD) prevention. […] Prevention includes 3 goals: Primary prevention identifies and removes causes so disease does not develop […] Secondary prevention identifies the disease processes and intervenes to prevent symptom onset […] Tertiary prevention reduces the burden and slows progression in manifest disease. […] Screening for alpha-synuclein abnormalities in individuals in higher risk strata (considering occupational and environmental toxicant exposures, behaviors, lifestyle, and genotype) provides an opportunity for secondary prevention. […] Applying precision medicine principles, starting with population-based risk stratification, incorporating individual-specific risk and biomarker profiles, will speed progress to prevention and reducing the global burden of PD.

• #6 Path to Parkinson Disease Prevention. Conclusion and Outlook | FocusOn Neurology

  https://focusonneurology.com/articles/path-to-parkinson-disease-prevention-conclusion-and-outlook

  Tremendous progress in our understanding of the pathophysiology and clinical manifestations of the prodromal phase of Parkinson disease (PD) offers a unique opportunity to start therapeutic interventions as early as possible to slow or even stop the progression to clinically manifest motor PD. […] We believe that the field has accumulated sufficient critical knowledge to start addressing the quintessential questions of designing interventional studies in individuals at risk for developing PD. […] As mentioned in the Introduction, we provide a framework for addressing the critical next steps in designing trials to prevent PD by addressing the following questions: Who (should be enrolled)? What (to test)? and How (to measure prevention)? complemented ultimately by When during the disease (should we start these trials)?

• #7 Aerobic exercise for Parkinson’s disease

  https://peterattiamd.com/benefit-of-exercise-in-parkinsons/

  The neuroprotective nature of aerobic exercise influences a variety of Parkinsons disease symptoms, on top of its role in impacting disease risk and progression […] exercise appears to delay or prevent disease onset, as epidemiological studies have reported that individuals with the highest levels of physical activity have the lowest future risk for PD. […] individuals in the highest category of weekly moderate to vigorous physical activity (e.g., jogging, tennis, stationary bike) at baseline had a 40% lower relative risk of developing PD than those not exercising at baseline. […] the highest levels of strenuous exercise from early adulthood were associated with a 60% and 50%, respectively, PD risk reduction in later life compared to those with the lowest levels. […] exercise is a form of lifestyle intervention that is not prohibitively difficult to integrate in PD and has immense benefits for its symptoms. […] this intervention also has utility as a neuroprotective strategy that could reduce the risk of developing PD, as well as extending the lifespan of remaining dopamine neurons that are vulnerable to degeneration even after disease onset.

• #8 Aerobic exercise for Parkinson’s disease

  https://peterattiamd.com/benefit-of-exercise-in-parkinsons/

  The neuroprotective nature of aerobic exercise influences a variety of Parkinsons disease symptoms, on top of its role in impacting disease risk and progression […] exercise appears to delay or prevent disease onset, as epidemiological studies have reported that individuals with the highest levels of physical activity have the lowest future risk for PD. […] individuals in the highest category of weekly moderate to vigorous physical activity (e.g., jogging, tennis, stationary bike) at baseline had a 40% lower relative risk of developing PD than those not exercising at baseline. […] the highest levels of strenuous exercise from early adulthood were associated with a 60% and 50%, respectively, PD risk reduction in later life compared to those with the lowest levels. […] exercise is a form of lifestyle intervention that is not prohibitively difficult to integrate in PD and has immense benefits for its symptoms. […] this intervention also has utility as a neuroprotective strategy that could reduce the risk of developing PD, as well as extending the lifespan of remaining dopamine neurons that are vulnerable to degeneration even after disease onset.

• #9 What and How Can Physical Activity Prevention Function on Parkinson’s Disease?

  https://pmc.ncbi.nlm.nih.gov/articles/PMC7042542/

  This study was aimed at investigating the effects and molecular mechanisms of physical activity intervention on Parkinson’s disease (PD) and providing theoretical guidance for the prevention and treatment of PD. […] Physical activity can reduce the risk and improve symptoms of PD and the beneficial forms of physical activity, including running, dancing, traditional Chinese martial arts, yoga, and weight training. […] Physical activity has a positive impact on the prevention and treatment of PD. […] Physical activity plays an active role in the prevention and treatment of PD. […] The results of prospective epidemiological studies suggest that active physical activity reduces the risk of PD in men, but the mechanism is uncertain. […] Physical activity treatment could also improve nonmotor functions in PD patients.

• #10 What and How Can Physical Activity Prevention Function on Parkinson’s Disease?

  https://pmc.ncbi.nlm.nih.gov/articles/PMC7042542/

  This study was aimed at investigating the effects and molecular mechanisms of physical activity intervention on Parkinson’s disease (PD) and providing theoretical guidance for the prevention and treatment of PD. […] Physical activity can reduce the risk and improve symptoms of PD and the beneficial forms of physical activity, including running, dancing, traditional Chinese martial arts, yoga, and weight training. […] Physical activity has a positive impact on the prevention and treatment of PD. […] Physical activity plays an active role in the prevention and treatment of PD. […] The results of prospective epidemiological studies suggest that active physical activity reduces the risk of PD in men, but the mechanism is uncertain. […] Physical activity treatment could also improve nonmotor functions in PD patients.

• #11 Prevent Parkinson’s Disease | Norton Healthcare

  https://nortonhealthcare.com/services-and-conditions/neurosciences/programs/parkinsons-disease/prevention/

  Can You Prevent Parkinson’s Disease? […] While there is no proven way to prevent Parkinson’s, there are some ways to slow the progression of the disease and reduce the severity of symptoms. Research has shown that lifestyle interventions may help prevent progression of Parkinson’s. […] A reduced risk of developing Parkinson’s disease. […] The Parkinson’s Outcomes Project shows that people with Parkinson’s who start exercising earlier in their disease course for a minimum of 2.5 hours per week experience a slowed decline in quality of life compared with those who start later. Establishing early exercise habits is essential to overall disease management. […] There has not been much solid evidence that dietary supplements have any effect on Parkinson’s symptoms. […] There is some evidence that your environment can contribute to your developing Parkinson’s. Exposure to metals, pesticides and certain drugs have been strongly linked to the onset of Parkinson’s.

• #12 What and How Can Physical Activity Prevention Function on Parkinson’s Disease?

  https://pmc.ncbi.nlm.nih.gov/articles/PMC7042542/

  Therefore, physical activity could enhance the chances of recovery through improvement in the mood and the nervous system in elderly PD patients. […] As a safe treatment, physical activity could relieve the symptoms in PD patients, such as motor dysfunction, cognitive deficits, and depression. […] Different forms of physical activity, especially the moderate to vigorous physical exercise, have a positive impact on PD through multiple mechanisms, including reducing the accumulation of the -syn protein and alleviating inflammation and oxidative stress, while enhancing BDNF activity, nerve regeneration, and mitochondrial function.

• #13 What and How Can Physical Activity Prevention Function on Parkinson’s Disease?

  https://pmc.ncbi.nlm.nih.gov/articles/PMC7042542/

  Therefore, physical activity could enhance the chances of recovery through improvement in the mood and the nervous system in elderly PD patients. […] As a safe treatment, physical activity could relieve the symptoms in PD patients, such as motor dysfunction, cognitive deficits, and depression. […] Different forms of physical activity, especially the moderate to vigorous physical exercise, have a positive impact on PD through multiple mechanisms, including reducing the accumulation of the -syn protein and alleviating inflammation and oxidative stress, while enhancing BDNF activity, nerve regeneration, and mitochondrial function.

• #14 Parkinson’s disease: Early signs, causes, and risk factors

  https://www.medicalnewstoday.com/articles/323396

  It is not possible to prevent Parkinsons disease, but some lifelong habits may help reduce the risk. […] People should take precautions when using potentially toxic chemicals, such as herbicides, pesticides, and solvents. […] Regular physical exercise may help prevent or treat Parkinsons disease, according to a 2018 review. The authors note that physical activity can help maintain dopamine levels in the brain. […] Some dietary choices may also help reduce the risk of Parkinsons and other diseases. Research has shown that the following may help: […] Exercise, a healthy diet, and avoiding toxins may all help prevent Parkinsons disease, but there is no current evidence to confirm the specific cause.

• #15 Can Exercise Help People with Parkinson’s Disease? 4 Things to Know > News > Yale Medicine

  https://www.yalemedicine.org/news/can-exercise-help-people-with-parkinsons

  Studies show that high-intensity exercise may slow the progression of the disease. […] Recent studies suggest that exercise may help slow the progression of the condition. […] Other research shows that high-intensity exercise appears to slow the progression of Parkinsons disease. […] They found that the disease in the exercising group did not progress much based on their neurological exam findings, Dr. Tinaz says. […] Taking it one step further, Dr. Tinaz and her colleagues conducted a small research study to see if engaging in high-intensity exercise (reaching 80% of a persons age-appropriate maximum heart rate) would not only slow disease progression but could improve neuron function in the brains of patients with Parkinsons disease. […] We found that high-intensity interval training three times a week for six months did increase the dopaminergic signal in the brain, which suggests it might actually improve neuron function.

• #16 High-intensity Exercise May Reverse Neurodegeneration in Parkinson’s Disease < Yale School of Medicine

  https://medicine.yale.edu/news-article/high-intensity-exercise-can-reverse-neurodegeneration-in-parkinsons-disease/

  High-intensity exercise induces brain-protective effects that have the potential to not just slow down, but possibly reverse, the neurodegeneration associated with Parkinsons disease, a new pilot study suggests. […] The medications we have available are only for symptomatic treatment. They do not change the disease course. But exercise seems to go one step beyond and protect the brain at the neuronal level. […] Exercise is an essential component of Parkinsons disease management. […] The study highlights the importance of including an exercise regimen as part of ones Parkinsons treatment plan. The medications we have available are only for symptomatic treatment. They do not change the disease course, says Tinaz. But exercise seems to go one step beyond and protect the brain at the neuronal level. […] Exercise is accessible to everyone, is relatively cheap, and is safe [if your health care provider approves], says Tinaz. If it also has this neuroprotective effect with the potential to reverse the disease course, that is something to celebrate and to study.

• #17 Parkinson’s Disease Diet | Mass General Brigham

  https://www.massgeneralbrigham.org/en/about/newsroom/articles/parkinsons-disease-diet

  Lifestyle changes such as eating well, exercising, and reducing stress can also help with Parkinsons disease. […] The disease process that leads to Parkinsons begins up to a decade before symptoms appear, Oliveira says. Its absolutely worthwhile to look at lifestyle factors such as diet. They may help delay the start of symptoms and slow the progression of the disease. […] Some research suggests that what you eat affects your brain health, and diet may even play a role in preventing Parkinsons disease. […] A large Harvard study on Parkinsons showed that people with very high intake of plant foods, including fruits, vegetables, beans, and whole grains, had a lower risk of developing Parkinsons disease, Oliveira says. […] A heart-healthy diet is also beneficial for brain health. […] Its about the synergistic effect of many different healthy foods working together, she says.

• #18 How to Prevent Parkinson’s Disease

  https://www.verywellhealth.com/how-to-prevent-parkinson-s-disease-5207428

  Diet and exercise may play key roles […] While there is no definitive way yet to prevent Parkinson’s disease, eating a „brain-healthy” diet and incorporating physical activity into your daily routine might help reduce the risk or delay symptom onset. […] Research suggests that sticking to certain diets or eating patterns may nourish your brain in a way that delays or stops PD from manifesting. […] The Mediterranean diet is rich in fruits, vegetables, olive oil, fish, and whole grains. It is associated with both a decreased risk of PD and a delayed onset of Parkinson’s disease symptoms. […] The MIND diet combines elements from the Mediterranean diet and the Dietary Approaches to Stop Hypertension (DASH) diet. It is also linked to a lower risk of and delayed onset of Parkinson’s disease.

• #19 How to Prevent Parkinson’s Disease

  https://www.verywellhealth.com/how-to-prevent-parkinson-s-disease-5207428

  Diet and exercise may play key roles […] While there is no definitive way yet to prevent Parkinson’s disease, eating a „brain-healthy” diet and incorporating physical activity into your daily routine might help reduce the risk or delay symptom onset. […] Research suggests that sticking to certain diets or eating patterns may nourish your brain in a way that delays or stops PD from manifesting. […] The Mediterranean diet is rich in fruits, vegetables, olive oil, fish, and whole grains. It is associated with both a decreased risk of PD and a delayed onset of Parkinson’s disease symptoms. […] The MIND diet combines elements from the Mediterranean diet and the Dietary Approaches to Stop Hypertension (DASH) diet. It is also linked to a lower risk of and delayed onset of Parkinson’s disease.

• #20 Parkinson’s Diet: Foods to Eat and Foods to Avoid

  https://www.healthline.com/health/parkinsons-and-diet

  More research has shown that diets high in antioxidants may provide brain-protective benefits and slow the progression of the disease in older adults. […] Eating more foods rich in antioxidants and omega-3s, as well as correcting any nutrient deficiencies, may help relieve some Parkinsons symptoms. […] People with Parkinsons may need to avoid or limit processed foods and foods high in saturated fats, as these may exacerbate symptoms. […] Some research suggests that the Mediterranean diet, which tends to be high in antioxidants and omega-3s, protects against dementia in Parkinsons disease. […] Experts also recommend the Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diet to slow Parkinsons progression. […] Recent research suggests that the keto diet may also benefit people with Parkinsons. […] Healthy lifestyle habits, such as staying hydrated, getting outside, and keeping active, may help relieve Parkinsons symptoms. […] However, a nutritious diet alongside regular exercise may help improve symptoms.

• #21 Parkinson’s Disease Diet | Mass General Brigham

  https://www.massgeneralbrigham.org/en/about/newsroom/articles/parkinsons-disease-diet

  Lifestyle changes such as eating well, exercising, and reducing stress can also help with Parkinsons disease. […] The disease process that leads to Parkinsons begins up to a decade before symptoms appear, Oliveira says. Its absolutely worthwhile to look at lifestyle factors such as diet. They may help delay the start of symptoms and slow the progression of the disease. […] Some research suggests that what you eat affects your brain health, and diet may even play a role in preventing Parkinsons disease. […] A large Harvard study on Parkinsons showed that people with very high intake of plant foods, including fruits, vegetables, beans, and whole grains, had a lower risk of developing Parkinsons disease, Oliveira says. […] A heart-healthy diet is also beneficial for brain health. […] Its about the synergistic effect of many different healthy foods working together, she says.

• #22 7 Scientifically Backed Ways to Prevent Parkinson’s Disease | Judson

  https://www.judsonsmartliving.org/blog/7-scientifically-backed-ways-to-prevent-parkinsons-disease/

  Studies show that increased amounts of the B vitamin folic acid, found primarily in vegetables, can significantly reduce the risk of Parkinsons. […] Parkinsons is inflammatory in nature, so researchers have spent much of their time exploring the anti-inflammatory effects of omega-3 fatty acids on the disease. Omega-3 fatty acids are strongly implicated in the prevention of cell degeneration and death, with their benefits going well beyond Parkinsons prevention. […] Researchers have found that about 70 percent of early, untreated Parkinsons patients have low levels of vitamin D identifying this statistic as a strong correlation would be an understatement. […] Multiple studies have shown that the certain compounds in green tea have myriad protective benefits on the neural network of the brain. Green tea has also been shown to sustain dopamine levels in ailing brain tissue, reducing the severity of Parkinsons symptoms for those already diagnosed.

• #23 7 Scientifically Backed Ways to Prevent Parkinson’s Disease | Judson

  https://www.judsonsmartliving.org/blog/7-scientifically-backed-ways-to-prevent-parkinsons-disease/

  Studies show that increased amounts of the B vitamin folic acid, found primarily in vegetables, can significantly reduce the risk of Parkinsons. […] Parkinsons is inflammatory in nature, so researchers have spent much of their time exploring the anti-inflammatory effects of omega-3 fatty acids on the disease. Omega-3 fatty acids are strongly implicated in the prevention of cell degeneration and death, with their benefits going well beyond Parkinsons prevention. […] Researchers have found that about 70 percent of early, untreated Parkinsons patients have low levels of vitamin D identifying this statistic as a strong correlation would be an understatement. […] Multiple studies have shown that the certain compounds in green tea have myriad protective benefits on the neural network of the brain. Green tea has also been shown to sustain dopamine levels in ailing brain tissue, reducing the severity of Parkinsons symptoms for those already diagnosed.

• #24 7 Scientifically Backed Ways to Prevent Parkinson’s Disease | Judson

  https://www.judsonsmartliving.org/blog/7-scientifically-backed-ways-to-prevent-parkinsons-disease/

  Regular aerobic exercise reduces inflammation in the brain, helping to counter the inflammatory signals leading to the development of Parkinsons. […] Deficiencies in CoQ10 have been shown to contribute to age-related neurodegenerative conditions like Alzheimers and Parkinsons, and patients with PD have been shown to have low levels of this crucial coenzyme in their platelets, plasma and vital regions of the brain. A variety of studies have demonstrated that CoQ10 supplementation can slow the progressive deterioration of Parkinsons and prevent dopamine loss. […] Whether youre seeking Parkinsons prevention techniques or ways to alleviate symptoms, any of the above dietary and lifestyle practices can have long-term health benefits. Drinking green tea, eating organic, local vegetables, and regular aerobic exercise all significantly reduce the long-term cumulative damage done by stress.

• #25 How to Prevent Parkinson’s Disease

  https://www.verywellhealth.com/how-to-prevent-parkinson-s-disease-5207428

  Incorporating caffeine into your diet is also a promising PD-preventive strategy. Numerous scientific studies have consistently linked caffeine consumption to a decreased risk for developing PD. […] Findings from clinical trials have shown that exercise, particularly moderate to vigorous physical activity, is associated with a lower risk of developing PD. […] Regular physical activity also decreases the likelihood of obesity, which is associated with an increased risk of Parkinson’s disease. […] Engaging in regular exercise and adopting the Mediterranean diet or MIND diet may help prevent or delay the onset of Parkinson’s disease. […] There is no absolute way yet to prevent Parkinson’s disease. That said, engaging in certain lifestyle factors like exercising and eating a well-balanced diet like the Mediterranean diet might help lower your risk or delay the onset of symptoms.

• #26 Parkinson’s disease – Symptoms and causes – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/parkinsons-disease/symptoms-causes/syc-20376055

  Because the cause of Parkinson’s disease is not known, there are no proven ways to prevent it. Research shows that some factors may help protect against it. But scientists don’t know for sure. These factors include: […] Exercise. Aerobic exercise has been linked to a lower risk of Parkinson’s disease. […] Caffeine. Some studies show a link between drinking caffeinated beverages such as coffee and green tea and a lower risk of Parkinson’s disease. […] Medicines. Some medicines, such as ibuprofen and statins, have been linked to a lower risk of the disease.

• #27 7 Scientifically Backed Ways to Prevent Parkinson’s Disease | Judson

  https://www.judsonsmartliving.org/blog/7-scientifically-backed-ways-to-prevent-parkinsons-disease/

  Studies show that increased amounts of the B vitamin folic acid, found primarily in vegetables, can significantly reduce the risk of Parkinsons. […] Parkinsons is inflammatory in nature, so researchers have spent much of their time exploring the anti-inflammatory effects of omega-3 fatty acids on the disease. Omega-3 fatty acids are strongly implicated in the prevention of cell degeneration and death, with their benefits going well beyond Parkinsons prevention. […] Researchers have found that about 70 percent of early, untreated Parkinsons patients have low levels of vitamin D identifying this statistic as a strong correlation would be an understatement. […] Multiple studies have shown that the certain compounds in green tea have myriad protective benefits on the neural network of the brain. Green tea has also been shown to sustain dopamine levels in ailing brain tissue, reducing the severity of Parkinsons symptoms for those already diagnosed.

• #28 Parkinson’s disease prevention may 'begin at the dinner table’

  https://www.wcvb.com/article/parkinsons-disease-prevention-may-begin-at-the-dinner-table/64705629

  Parkinson’s disease prevention may ‘begin at the dinner table’ […] Eating about a dozen servings of ultraprocessed food each day could more than double your risk of developing Parkinson’s disease, according to a new study. […] „Our research shows that eating too much processed food, like sugary sodas and packaged snacks, might be speeding up early signs of Parkinson’s disease,” said senior study author Dr. Xiang Gao. […] „The prevention of neurodegenerative diseases may begin at the dinner table,” they wrote. „Excessive UPF consumption not only is a risk factor for metabolic diseases but may also accelerate neurodegenerative processes and associated symptoms.” […] „Choosing to eat fewer processed foods and more whole, nutritious foods could be a good strategy for maintaining brain health.”

• #29 Parkinson’s disease prevention may 'begin at the dinner table’

  https://www.wlwt.com/article/parkinsons-disease-prevention-may-begin-at-the-dinner-table/64705629

  Parkinson’s disease prevention may ‘begin at the dinner table’ […] Eating about a dozen servings of ultraprocessed food each day could more than double your risk of developing Parkinson’s disease, according to a new study. […] „Our research shows that eating too much processed food, like sugary sodas and packaged snacks, might be speeding up early signs of Parkinson’s disease,” said senior study author Dr. Xiang Gao, a distinguished professor and dean of the Institute of Nutrition at Fudan University in Shanghai, China, in a statement. […] „The prevention of neurodegenerative diseases may begin at the dinner table,” they wrote. „Excessive UPF consumption not only is a risk factor for metabolic diseases but may also accelerate neurodegenerative processes and associated symptoms.” […] „Choosing to eat fewer processed foods and more whole, nutritious foods could be a good strategy for maintaining brain health.”

• #30 Parkinson’s disease prevention may ‘begin at the dinner table’ | Health | news8000.com

  https://www.news8000.com/lifestyle/health/parkinson-s-disease-prevention-may-begin-at-the-dinner-table/article_3a12f1de-e813-5d70-8176-ef1f68d3b5b2.html

  Eating about a dozen servings of ultraprocessed food each day could more than double your risk of developing Parkinson’s disease, according to a new study. […] “Our research shows that eating too much processed food, like sugary sodas and packaged snacks, might be speeding up early signs of Parkinson’s disease,” said senior study author Dr. Xiang Gao. […] This latest study is part of the “growing evidence that diet might influence the development of Parkinson’s disease,” Gao said. […] “The prevention of neurodegenerative diseases may begin at the dinner table,” they wrote. “Excessive UPF consumption not only is a risk factor for metabolic diseases but may also accelerate neurodegenerative processes and associated symptoms.” […] “Choosing to eat fewer processed foods and more whole, nutritious foods could be a good strategy for maintaining brain health.”

• #31 7 Scientifically Backed Ways to Prevent Parkinson’s Disease | Judson

  https://www.judsonsmartliving.org/blog/7-scientifically-backed-ways-to-prevent-parkinsons-disease/

  Parkinsons now afflicts roughly 1.5 million people in the United States alone, with primary symptoms being body tremors, slow movement, rigid limbs, reduced memory, a shuffling gait and speech impairment. […] Currently there isnt a known cure, and its not fully understood what causes the dip in dopamine; however, we know that aging is the single most important risk factor for PD, with inflammation and stress contributing to cell damage. And we now know enough about the disease to understand the preventative measures that counter the aging and death of the neurons under attack. […] Because there is no known cure, its critical that we prevent the disease before symptoms arise. […] Researchers have found high levels of pesticides/herbicides in the brains of Parkinsons sufferers, compared to those with regular dopamine levels. Furthermore, agricultural workers who find themselves exposed to these pesticides have significantly higher rates of PD than the general public.

• #32 Victory in Parkinson’s Prevention: EPA bans Harmful Toxins

  https://cndlifesciences.com/epa-bans-harmful-toxins/

  In December 2024, the U.S. Environmental Protection Agency (EPA) announced a plan to limit and eventually ban the use of trichloroethylene (TCE) and perchloroethylene (PCE), widely used industrial chemicals linked to serious health issues, including Parkinson’s disease. […] The connection between TCE exposure to humans and Parkinson’s disease was demonstrated by a 2023 cohort study involving veterans stationed at Camp Lejeune. […] TCE exposure is known to lead to toxic effects on mitochondria, resulting in increased oxidative stress and, eventually, cell death of dopamine-producing neurons in the brain. […] PFAS chemical exposures have been linked to PD, Alzheimer’s disease, and ADHD. […] These chemicals exert damaging effects by disrupting the blood-brain barrier, altering neurotransmitter levels, including dopamine, and promoting the aggregation of alpha-synuclein, known to be associated with the pathology of Parkinson’s disease and related conditions.

• #33 Victory in Parkinson’s Prevention: EPA bans Harmful Toxins

  https://cndlifesciences.com/epa-bans-harmful-toxins/

  Other chemicals, such as herbicides, paraquat and glyphosate, continue to be utilized in the U.S., despite evidence of increased risk of Parkinson’s and other serious health conditions. […] Additionally, emerging research suggests that environmental factors like air pollution and microplastics may contribute to the development of Parkinson’s disease and other chronic health conditions. […] According to the EPA and the book Ending Parkinson’s Disease, individuals can minimize exposure to environmental toxins and potentially reduce the risk of Parkinson’s and other chronic health conditions by: […] Reducing the use of household products containing harmful solvents and chemicals. […] Monitoring air quality: Consider air purifiers for indoor use, avoid prolonged outdoor activities on high pollution days, and/or consider the use of masks to filter out particulate matter in areas of high pollution. […] Monitoring water quality. Consider the use of water filtration systems to reduce contaminants. […] By joining these efforts, citizens can tap into the potential for reducing the burden of chronic health conditions such as Parkinson’s disease, for both current and future generations.

• #34 Victory in Parkinson’s Prevention: EPA bans Harmful Toxins

  https://cndlifesciences.com/epa-bans-harmful-toxins/

  In December 2024, the U.S. Environmental Protection Agency (EPA) announced a plan to limit and eventually ban the use of trichloroethylene (TCE) and perchloroethylene (PCE), widely used industrial chemicals linked to serious health issues, including Parkinson’s disease. […] The connection between TCE exposure to humans and Parkinson’s disease was demonstrated by a 2023 cohort study involving veterans stationed at Camp Lejeune. […] TCE exposure is known to lead to toxic effects on mitochondria, resulting in increased oxidative stress and, eventually, cell death of dopamine-producing neurons in the brain. […] PFAS chemical exposures have been linked to PD, Alzheimer’s disease, and ADHD. […] These chemicals exert damaging effects by disrupting the blood-brain barrier, altering neurotransmitter levels, including dopamine, and promoting the aggregation of alpha-synuclein, known to be associated with the pathology of Parkinson’s disease and related conditions.

• #35 Victory in Parkinson’s Prevention: EPA bans Harmful Toxins

  https://cndlifesciences.com/epa-bans-harmful-toxins/

  Other chemicals, such as herbicides, paraquat and glyphosate, continue to be utilized in the U.S., despite evidence of increased risk of Parkinson’s and other serious health conditions. […] Additionally, emerging research suggests that environmental factors like air pollution and microplastics may contribute to the development of Parkinson’s disease and other chronic health conditions. […] According to the EPA and the book Ending Parkinson’s Disease, individuals can minimize exposure to environmental toxins and potentially reduce the risk of Parkinson’s and other chronic health conditions by: […] Reducing the use of household products containing harmful solvents and chemicals. […] Monitoring air quality: Consider air purifiers for indoor use, avoid prolonged outdoor activities on high pollution days, and/or consider the use of masks to filter out particulate matter in areas of high pollution. […] Monitoring water quality. Consider the use of water filtration systems to reduce contaminants. […] By joining these efforts, citizens can tap into the potential for reducing the burden of chronic health conditions such as Parkinson’s disease, for both current and future generations.

• #36 Victory in Parkinson’s Prevention: EPA bans Harmful Toxins

  https://cndlifesciences.com/epa-bans-harmful-toxins/

  Other chemicals, such as herbicides, paraquat and glyphosate, continue to be utilized in the U.S., despite evidence of increased risk of Parkinson’s and other serious health conditions. […] Additionally, emerging research suggests that environmental factors like air pollution and microplastics may contribute to the development of Parkinson’s disease and other chronic health conditions. […] According to the EPA and the book Ending Parkinson’s Disease, individuals can minimize exposure to environmental toxins and potentially reduce the risk of Parkinson’s and other chronic health conditions by: […] Reducing the use of household products containing harmful solvents and chemicals. […] Monitoring air quality: Consider air purifiers for indoor use, avoid prolonged outdoor activities on high pollution days, and/or consider the use of masks to filter out particulate matter in areas of high pollution. […] Monitoring water quality. Consider the use of water filtration systems to reduce contaminants. […] By joining these efforts, citizens can tap into the potential for reducing the burden of chronic health conditions such as Parkinson’s disease, for both current and future generations.

• #37 Victory in Parkinson’s Prevention: EPA bans Harmful Toxins

  https://cndlifesciences.com/epa-bans-harmful-toxins/

  Other chemicals, such as herbicides, paraquat and glyphosate, continue to be utilized in the U.S., despite evidence of increased risk of Parkinson’s and other serious health conditions. […] Additionally, emerging research suggests that environmental factors like air pollution and microplastics may contribute to the development of Parkinson’s disease and other chronic health conditions. […] According to the EPA and the book Ending Parkinson’s Disease, individuals can minimize exposure to environmental toxins and potentially reduce the risk of Parkinson’s and other chronic health conditions by: […] Reducing the use of household products containing harmful solvents and chemicals. […] Monitoring air quality: Consider air purifiers for indoor use, avoid prolonged outdoor activities on high pollution days, and/or consider the use of masks to filter out particulate matter in areas of high pollution. […] Monitoring water quality. Consider the use of water filtration systems to reduce contaminants. […] By joining these efforts, citizens can tap into the potential for reducing the burden of chronic health conditions such as Parkinson’s disease, for both current and future generations.

• #38 Prevention of parkinson’s disease in Turkey – Bimaristan

  https://bi-maristan.com/en/neurosurgery/parkinson-disease/prevention-of-parkinsons-disease/

  The prevention of Parkinsons disease is achievable by maintaining a healthy lifestyle and minimizing stress, helping you reduce the risk as you age. […] The prevention of Parkinsons disease is crucial, as its exact cause remains unclear. While the condition is linked to brain inflammation, adopting strategies to avoid it can help reduce the risk. […] The prevention of Parkinsons disease involves addressing factors that influence dopamine production and overall brain health. […] Therefore, prevention of Parkinsons disease before it occurs is better than treatment, and there are effective attempts to study ways to prevent Parkinsons disease, the most important of which are: […] Using organic pesticides is one effective method for the prevention of Parkinsons disease. […] For the prevention of Parkinsons disease, ensuring adequate folic acid intake from dark green vegetables like broccoli, kale, okra, and spinach can help reduce the risk.

• #39 10 Tips to Prevent Parkinson’s Disease – NurseRegistry

  https://www.nurseregistry.com/blog/tips-to-prevent-parkinsons-disease/

  While theres no guaranteed way to prevent Parkinsons, emerging research suggests that certain lifestyle choices may help reduce the risk of developing this condition. […] Lifestyle factors such as exercise and diet can play a role in preventing Parkinsons disease. […] Avoiding exposure to environmental toxins may also reduce the risk of developing Parkinsons disease. […] While there is no cure for Parkinsons disease, taking preventative measures can help delay the onset of the disease. […] Environmental toxins contribute to Parkinsons disease development. […] Other environmental factors that may contribute to Parkinsons disease include exposure to heavy metals, such as lead and mercury, and air pollution. […] To protect yourself, its crucial to minimize exposure to pesticides and herbicides.

• #40 Parkinson’s disease – Symptoms and causes – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/parkinsons-disease/symptoms-causes/syc-20376055

  Because the cause of Parkinson’s disease is not known, there are no proven ways to prevent it. Research shows that some factors may help protect against it. But scientists don’t know for sure. These factors include: […] Exercise. Aerobic exercise has been linked to a lower risk of Parkinson’s disease. […] Caffeine. Some studies show a link between drinking caffeinated beverages such as coffee and green tea and a lower risk of Parkinson’s disease. […] Medicines. Some medicines, such as ibuprofen and statins, have been linked to a lower risk of the disease.

• #41 Parkinson’s disease – Symptoms and causes – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/parkinsons-disease/symptoms-causes/syc-20376055

  Because the cause of Parkinson’s disease is not known, there are no proven ways to prevent it. Research shows that some factors may help protect against it. But scientists don’t know for sure. These factors include: […] Exercise. Aerobic exercise has been linked to a lower risk of Parkinson’s disease. […] Caffeine. Some studies show a link between drinking caffeinated beverages such as coffee and green tea and a lower risk of Parkinson’s disease. […] Medicines. Some medicines, such as ibuprofen and statins, have been linked to a lower risk of the disease.

• #42 How to Prevent Parkinson’s Disease: Tips, Medications, and Research

  https://www.healthline.com/health/parkinsons/how-to-prevent-parkinsons

  Researchers aim to learn more about biomarkers of the early stages of the disease. Finding reliable biological identifiers might help doctors diagnose and treat Parkinsons earlier. […] Ongoing research into a gene called LRRK2 or LARK2 and how it may interact with other genes related to Parkinsons disease is also promising, as it may shed light on how the disease progresses and how it might be halted. […] The results of a study published in early 2021 suggest that certain medications often used to treat enlarged prostates are associated with a decreased risk of developing Parkinsons disease. […] For now, the symptoms of Parkinsons disease can be managed with medication and potentially deep brain stimulation. But research is underway to look for earlier methods of detection, as well as better treatments. Eventually, we might even have a way to prevent it from developing in the first place.

• #43 10 Tips to Prevent Parkinson’s Disease – NurseRegistry

  https://www.nurseregistry.com/blog/tips-to-prevent-parkinsons-disease/

  Regular exercise acts like a shield for the precious dopamine-producing neurons in your brain. […] The Mediterranean diet, rich in fruits, vegetables, whole grains, and healthy fats, has shown promise in reducing PD risk. […] Sleep hygiene affects Parkinsons disease risk. […] Chronic stress has been linked to an increased risk of Parkinsons disease. […] Cognitive stimulation prevents Parkinsons disease by promoting neuroplasticity and building cognitive reserve. […] Research suggests that people with strong social connections and those who regularly engage with others might be giving their minds an extra layer of protection against cognitive decline and neurodegenerative diseases like Parkinsons. […] Head injuries increase the risk of Parkinsons disease. […] Engaging in regular exercise, particularly moderate-to-vigorously intense physical activities, may help delay the onset of Parkinsons disease. […] Understanding your risks, early detection, and lifestyle changes may help slow its progression and delay its onset.

• #44 Parkinson’s Disease – Causes, Symptoms, Treatment and Prevention PACE Hospitals – Best Hospitals in Hitech City, Hyderabad, India | Near Madhapur, Kukatpally, KPHB, Kondapur, Gachibowli, Jubilee Hills, Banjara HillsPACE Hospitals Contact

  https://www.pacehospital.com/parkinsons-disease-causes-symptoms-treatment-prevention

  Parkinson’s Disease prevention does not have a standard approach, but certain lifestyle changes may help to reduce the risk, including: […] Regular physical exercise promotes overall health and lowers the risk of Parkinson’s disease. Walking, swimming, and strength training are beneficial exercises for Parkinson’s diseases as these improves blood flow, supports brain health, and helps maintain motor function. […] Avoiding contact with environmental toxins like pesticides and heavy metals is essential to prevent PD. […] Some research suggested that reduced risk of Parkinson’s disease is linked to moderate caffeine intake. Caffeine’s potential neuroprotective effects are still under research so that moderate intake may be beneficial, but it should be balanced with other health considerations. […] Protecting the head from trauma, such as wearing helmets during biking or contact sports, to reduce the risk of trauma. […] If Parkinson’s disease runs in the family, consulting with a genetic counsellor provides insights into risk and potential preventive strategies.

• #45 10 Tips to Prevent Parkinson’s Disease – NurseRegistry

  https://www.nurseregistry.com/blog/tips-to-prevent-parkinsons-disease/

  Regular exercise acts like a shield for the precious dopamine-producing neurons in your brain. […] The Mediterranean diet, rich in fruits, vegetables, whole grains, and healthy fats, has shown promise in reducing PD risk. […] Sleep hygiene affects Parkinsons disease risk. […] Chronic stress has been linked to an increased risk of Parkinsons disease. […] Cognitive stimulation prevents Parkinsons disease by promoting neuroplasticity and building cognitive reserve. […] Research suggests that people with strong social connections and those who regularly engage with others might be giving their minds an extra layer of protection against cognitive decline and neurodegenerative diseases like Parkinsons. […] Head injuries increase the risk of Parkinsons disease. […] Engaging in regular exercise, particularly moderate-to-vigorously intense physical activities, may help delay the onset of Parkinsons disease. […] Understanding your risks, early detection, and lifestyle changes may help slow its progression and delay its onset.

• #46 Prevent Parkinson’s Disease | Norton Healthcare

  https://nortonhealthcare.com/services-and-conditions/neurosciences/programs/parkinsons-disease/prevention/

  There has been some research that suggests traumatic brain injury (TBI) may contribute to the onset of Parkinson’s. […] The severity of Parkinson’s symptoms varies from person to person, but patients have noted that symptoms get worse with: Lack of exercise. […] There is no known cause or cure for Parkinson’s disease, but there are many ways to manage symptoms and possibly to keep symptoms at bay for longer.

• #47 10 Tips to Prevent Parkinson’s Disease – NurseRegistry

  https://www.nurseregistry.com/blog/tips-to-prevent-parkinsons-disease/

  Regular exercise acts like a shield for the precious dopamine-producing neurons in your brain. […] The Mediterranean diet, rich in fruits, vegetables, whole grains, and healthy fats, has shown promise in reducing PD risk. […] Sleep hygiene affects Parkinsons disease risk. […] Chronic stress has been linked to an increased risk of Parkinsons disease. […] Cognitive stimulation prevents Parkinsons disease by promoting neuroplasticity and building cognitive reserve. […] Research suggests that people with strong social connections and those who regularly engage with others might be giving their minds an extra layer of protection against cognitive decline and neurodegenerative diseases like Parkinsons. […] Head injuries increase the risk of Parkinsons disease. […] Engaging in regular exercise, particularly moderate-to-vigorously intense physical activities, may help delay the onset of Parkinsons disease. […] Understanding your risks, early detection, and lifestyle changes may help slow its progression and delay its onset.

• #48 Parkinson’s Prevention: 5 Lifestyle Changes to Reduce Your Risk of Parkinson’s – Homage Malaysia

  https://www.homage.com.my/health/parkinsons-prevention/

  Increasing its intake helps Parkinson’s disease prevention particularly the risks for young-onset. […] Moderate to high levels of vitamin E in daily diets helps protect the brain from the risk of Parkinson’s disease. […] Opting for an organic diet helps keep Parkinson’s disease risk at bay. […] Not getting adequate amounts of sleep, in the long run, will potentially increase the risk of neurodegenerative diseases such as Parkinson’s. […] Those who exercise more, regardless of the strenuous level, have a lower tendency in developing the symptoms of Parkinson’s disease. […] Regular aerobic exercise can reduce inflammation in the brain. In other words, aerobic exercise can prevent the inflammatory signals that lead to Parkinson’s disease. […] Getting a sufficient amount of vitamin D has been proven to be important in lowering the risk of Parkinson’s disease.

• #49 10 Tips to Prevent Parkinson’s Disease – NurseRegistry

  https://www.nurseregistry.com/blog/tips-to-prevent-parkinsons-disease/

  Regular exercise acts like a shield for the precious dopamine-producing neurons in your brain. […] The Mediterranean diet, rich in fruits, vegetables, whole grains, and healthy fats, has shown promise in reducing PD risk. […] Sleep hygiene affects Parkinsons disease risk. […] Chronic stress has been linked to an increased risk of Parkinsons disease. […] Cognitive stimulation prevents Parkinsons disease by promoting neuroplasticity and building cognitive reserve. […] Research suggests that people with strong social connections and those who regularly engage with others might be giving their minds an extra layer of protection against cognitive decline and neurodegenerative diseases like Parkinsons. […] Head injuries increase the risk of Parkinsons disease. […] Engaging in regular exercise, particularly moderate-to-vigorously intense physical activities, may help delay the onset of Parkinsons disease. […] Understanding your risks, early detection, and lifestyle changes may help slow its progression and delay its onset.

• #50 Prevention of parkinson’s disease in Turkey – Bimaristan

  https://bi-maristan.com/en/neurosurgery/parkinson-disease/prevention-of-parkinsons-disease/

  The prevention of Parkinsons disease is achievable by maintaining a healthy lifestyle and minimizing stress, helping you reduce the risk as you age. […] The prevention of Parkinsons disease is crucial, as its exact cause remains unclear. While the condition is linked to brain inflammation, adopting strategies to avoid it can help reduce the risk. […] The prevention of Parkinsons disease involves addressing factors that influence dopamine production and overall brain health. […] Therefore, prevention of Parkinsons disease before it occurs is better than treatment, and there are effective attempts to study ways to prevent Parkinsons disease, the most important of which are: […] Using organic pesticides is one effective method for the prevention of Parkinsons disease. […] For the prevention of Parkinsons disease, ensuring adequate folic acid intake from dark green vegetables like broccoli, kale, okra, and spinach can help reduce the risk.

• #51

  https://www.movementdisorders.org/Moving-Along/2023-issue-3/Using-precision-medicine-Parkinsons-disease-prevention.htm

  We are starting to unravel how a persons unique biology could affect their treatment. […] In this lecture, I will apply a combination of public health and precision medicine principles to Parkinsons disease (PD) prevention. […] Prevention includes 3 goals: Primary prevention identifies and removes causes so disease does not develop […] Secondary prevention identifies the disease processes and intervenes to prevent symptom onset […] Tertiary prevention reduces the burden and slows progression in manifest disease. […] Screening for alpha-synuclein abnormalities in individuals in higher risk strata (considering occupational and environmental toxicant exposures, behaviors, lifestyle, and genotype) provides an opportunity for secondary prevention. […] Applying precision medicine principles, starting with population-based risk stratification, incorporating individual-specific risk and biomarker profiles, will speed progress to prevention and reducing the global burden of PD.

• #52 How to Prevent Parkinson’s Disease: Tips, Medications, and Research

  https://www.healthline.com/health/parkinsons/how-to-prevent-parkinsons

  Currently, there is no therapy or treatment that can slow the progression of Parkinsons or effectively relieve advanced symptoms, according to the NINDS. […] While its not yet known if there are surefire ways to prevent Parkinsons disease, there are a few things experts recommend. […] For example, research indicates that it may be useful to study the activity of a neuronal protein in the brain known as -synuclein, or alpha-synuclein. […] Some research, including a 2018 review of studies, suggest that cannabidiol (CBD) might help prevent Parkinsons disease. […] Scientists are also working to learn more about environmental factors and genetic factors that might contribute to the risk of developing Parkinsons. […] A 2019 study noted that measurements of -synuclein have shown encouraging preliminary results with regard to potential early diagnosis.

• #53 How to Prevent Parkinson’s Disease: Tips, Medications, and Research

  https://www.healthline.com/health/parkinsons/how-to-prevent-parkinsons

  Currently, there is no therapy or treatment that can slow the progression of Parkinsons or effectively relieve advanced symptoms, according to the NINDS. […] While its not yet known if there are surefire ways to prevent Parkinsons disease, there are a few things experts recommend. […] For example, research indicates that it may be useful to study the activity of a neuronal protein in the brain known as -synuclein, or alpha-synuclein. […] Some research, including a 2018 review of studies, suggest that cannabidiol (CBD) might help prevent Parkinsons disease. […] Scientists are also working to learn more about environmental factors and genetic factors that might contribute to the risk of developing Parkinsons. […] A 2019 study noted that measurements of -synuclein have shown encouraging preliminary results with regard to potential early diagnosis.

• #54 How to Prevent Parkinson’s Disease: Tips, Medications, and Research

  https://www.healthline.com/health/parkinsons/how-to-prevent-parkinsons

  Researchers aim to learn more about biomarkers of the early stages of the disease. Finding reliable biological identifiers might help doctors diagnose and treat Parkinsons earlier. […] Ongoing research into a gene called LRRK2 or LARK2 and how it may interact with other genes related to Parkinsons disease is also promising, as it may shed light on how the disease progresses and how it might be halted. […] The results of a study published in early 2021 suggest that certain medications often used to treat enlarged prostates are associated with a decreased risk of developing Parkinsons disease. […] For now, the symptoms of Parkinsons disease can be managed with medication and potentially deep brain stimulation. But research is underway to look for earlier methods of detection, as well as better treatments. Eventually, we might even have a way to prevent it from developing in the first place.

• #55

  https://www.movementdisorders.org/Moving-Along/2023-issue-3/Using-precision-medicine-Parkinsons-disease-prevention.htm

  We are starting to unravel how a persons unique biology could affect their treatment. […] In this lecture, I will apply a combination of public health and precision medicine principles to Parkinsons disease (PD) prevention. […] Prevention includes 3 goals: Primary prevention identifies and removes causes so disease does not develop […] Secondary prevention identifies the disease processes and intervenes to prevent symptom onset […] Tertiary prevention reduces the burden and slows progression in manifest disease. […] Screening for alpha-synuclein abnormalities in individuals in higher risk strata (considering occupational and environmental toxicant exposures, behaviors, lifestyle, and genotype) provides an opportunity for secondary prevention. […] Applying precision medicine principles, starting with population-based risk stratification, incorporating individual-specific risk and biomarker profiles, will speed progress to prevention and reducing the global burden of PD.

• #56 Therapeutics | Parkinson’s Progression Markers Initiative

  https://www.ppmi-info.org/study-design/path-to-prevention-platform-trial

  PPMI is primed to advance innovative trial design for Parkinsons prevention. […] The Path to Prevention (P2P) platform trial is designed to catalyze clinical development for prodromal PD. […] P2P capitalizes on PPMI study infrastructure, expertise, and ongoing clinical and biomarker data collection to de-risk industry investments in pioneering therapies for individuals at risk of PD diagnosis. […] The Path to Prevention (P2P) Platform Trial is seeking initial interest in partnering. Selected companies will work collaboratively with P2P and MJFF toward formal partnership around the platform trial.

• #57 Therapeutics | Parkinson’s Progression Markers Initiative

  https://www.ppmi-info.org/study-design/path-to-prevention-platform-trial

  PPMI is primed to advance innovative trial design for Parkinsons prevention. […] The Path to Prevention (P2P) platform trial is designed to catalyze clinical development for prodromal PD. […] P2P capitalizes on PPMI study infrastructure, expertise, and ongoing clinical and biomarker data collection to de-risk industry investments in pioneering therapies for individuals at risk of PD diagnosis. […] The Path to Prevention (P2P) Platform Trial is seeking initial interest in partnering. Selected companies will work collaboratively with P2P and MJFF toward formal partnership around the platform trial.

• #58 2024 Planning for Prevention of Parkinson’s: A Trial Design Forum, Sun, May 5th, 2024 @ 1:30 PM Accelevents

  https://www.accelevents.com/e/2024-planning-for-prevention-of-parkinsons-a-trial0

  Join us in Boston or online from Sunday, May 5th to Tuesday, May 7th, 2024, for the 3rd Planning for Prevention of Parkinson’s: A trial design forum! […] This forum will bring together academic, foundation, government, industry, patient and at-risk advocacy, and regulatory stakeholders to build on progress toward the development of the first Parkinson’s disease prevention trials and the success of our 2021 & 2022 conferences. […] A second (preceding) elective excursion, „Exercise & PD Prevention” an interactive walking talk led by Prof. Bas Bloem, is open to all in-person registrants. […] Planning for Prevention of Parkinson’s: A trial design forum is endorsed by the International Parkinson and Movement Disorder Society and the Parkinson Study Group.

• #59 Perspective and Consensus on Prevention Planning for Parkinson’s Disease | Parkinson’s Disease

  https://www.michaeljfox.org/grant/perspective-and-consensus-prevention-planning-parkinsons-disease

  Study Rationale: In October 2022, a conference on Planning for Prevention of Parkinson’s: A trial design forum gathered a broad range of stakeholders interested in preventing Parkinsons disease (PD), including at-risk and patient advocates, to advance emerging prospects for the first rigorous trials for the prevention of PD. […] We will initiate rigorous clinical trials designed to determine whether candidate therapies can prevent PD among individuals who are at high risk.

• #60 Planning for Prevention of Parkinson Disease

  https://pmc.ncbi.nlm.nih.gov/articles/PMC10519135/

  NMS have been identified throughout the various stages of PD from preclinical to advanced stages. […] A more useful approach may be considering them in combination with establishment of a composite prodromal cohort for prevention studies. […] Therapeutic options for prevention trials range from pharmacologic agents to genetic therapies to lifestyle measures. […] Thus, such decisions should be made by researchers and regulators in partnership with representatives of those at risk. […] Research advances over the past 30 years now allow for the systematic design and implementation of PD prevention trials. […] A variety of compelling therapeutic candidates are already available and include lifestyle measures, repurposed agents, and gene therapies.

• #61 Planning for Prevention of Parkinson Disease

  https://pmc.ncbi.nlm.nih.gov/articles/PMC10519135/

  Now is the time to start comprehensively designing and implementing trials to prevent Parkinson disease (PD). Prevention, a once insurmountable challenge in PD is now a more realistic endeavor. […] Trials are more likely to ultimately succeed if they incorporate these basic design elements together with the perspectives of the affected community. Hence, prevention trial planning will benefit from early engagement of all key stakeholders, from advocates both at-risk and manifesting to treating physicians, to investigators, to investors, and from academia, government, industry, and philanthropy. […] Enrolling at-risk participants just before PD phenoconversion (when diagnostic clinical criteria of PD are first met), or earlier, preceding the development of even subtle motor or imaging deficits, may eliminate a major reason for the consistent inefficacy of candidate disease-modifying therapy in de novo PD trials to date. […] This expansion of prevention research in the PD field follows on from studies in Alzheimer disease (AD) in individuals who are cognitively normal but at risk for AD (preclinical stage of disease) because of the presence of a biomarker of pathology (e.g., amyloid) or carrying pathogenic genetic variants associated with developing AD and from those with presymptomatic genetically confirmed Huntington disease (HD).

• #62 Planning for Prevention of Parkinson Disease

  https://pmc.ncbi.nlm.nih.gov/articles/PMC10519135/

  NMS have been identified throughout the various stages of PD from preclinical to advanced stages. […] A more useful approach may be considering them in combination with establishment of a composite prodromal cohort for prevention studies. […] Therapeutic options for prevention trials range from pharmacologic agents to genetic therapies to lifestyle measures. […] Thus, such decisions should be made by researchers and regulators in partnership with representatives of those at risk. […] Research advances over the past 30 years now allow for the systematic design and implementation of PD prevention trials. […] A variety of compelling therapeutic candidates are already available and include lifestyle measures, repurposed agents, and gene therapies.

• #63 Parkinson’s Prevention: 5 Lifestyle Changes to Reduce Your Risk of Parkinson’s – Homage Malaysia

  https://www.homage.com.my/health/parkinsons-prevention/

  Avoiding exposure to toxins outdoors helps preserve overall and brain health. […] It is always best to keep the home safe, especially for the seniors. […] Your best bet to prevent Parkinson’s is by adopting a brain-healthy, proactive lifestyle. If you incorporate the above diet and lifestyle tips into your routine, it will prove to be highly beneficial in keeping Parkinson’s disease at bay.

• #64 Parkinson’s Prevention: 5 Lifestyle Changes to Reduce Your Risk of Parkinson’s – Homage Malaysia

  https://www.homage.com.my/health/parkinsons-prevention/

  Avoiding exposure to toxins outdoors helps preserve overall and brain health. […] It is always best to keep the home safe, especially for the seniors. […] Your best bet to prevent Parkinson’s is by adopting a brain-healthy, proactive lifestyle. If you incorporate the above diet and lifestyle tips into your routine, it will prove to be highly beneficial in keeping Parkinson’s disease at bay.

• #65 Parkinson’s Disease Prevention: Delaying Onset

  https://www.health.com/parkinsons-disease-prevention-7151694

  The exact causes of Parkinsons disease are still unknown, and theres no outright cure for this progressive disease. However, there are some methods that may help prevent its onset and slow its progression. […] To slow its progression, certain lifestyle and dietary changes may help. […] Regular exercise has been found to slow the progression of Parkinsons disease and potentially delay its onset. […] Adopting a Mediterranean diet, which is high in vegetables, fruit, unsaturated fat, whole grain, and nut-intake, may help delay the onset of Parkinsons disease. […] Diets that are lower in dairy products, such as cheese, milk, and yogurt, may also reduce the risk of developing Parkinsons disease. […] Studies have shown caffeineas in coffee or teato be a protective factor, meaning it may help delay onset. […] Alongside other methods, some complementary approaches to Parkinsons disease prevention and management. […] While there is no way to truly prevent it, knowing your risks, early detection, and lifestyle changes may help slow its progress and delay its onset.

• #66 Exercise as medicine in Parkinson’s disease | Journal of Neurology, Neurosurgery & Psychiatry

  https://jnnp.bmj.com/content/95/11/1077

  To summarise, evidence support that people engaged in higher levels of moderate to vigorous physical activities in middle or later life have a lowered risk of PD. […] This compelling evidence is conceptualised in figure 1 showing that regular, potentially lifelong, exercise decreases the risk of PD or potentially postpones the time of diagnosis. […] The existing evidence on exercise and PD suggests that exercise should be prescribed along relevant medication to pwPD as early as possible. […] Also, given the safety and feasibility of exercise in PD there appears to be no harm in prescribing exercise for those at risk of developing PD (ie, rapid eye movement sleep behaviour disorder, genetic predisposition) to reduce the risk of developing PD or potentially prolong the time to diagnosis.

• #67 Exercise as medicine in Parkinson’s disease | Journal of Neurology, Neurosurgery & Psychiatry

  https://jnnp.bmj.com/content/95/11/1077

  Convincing evidence suggests that exercise offers primary and tertiary prevention in pwPD, whereas evidence for secondary prevention is less robust although highly plausible. Exercise should therefore be considered as medicine in pwPD and should be prescribed as an adjunct treatment as early as possible.

• #68 Exercise as medicine in Parkinson’s disease | Journal of Neurology, Neurosurgery & Psychiatry

  https://jnnp.bmj.com/content/95/11/1077

  To summarise, evidence support that people engaged in higher levels of moderate to vigorous physical activities in middle or later life have a lowered risk of PD. […] This compelling evidence is conceptualised in figure 1 showing that regular, potentially lifelong, exercise decreases the risk of PD or potentially postpones the time of diagnosis. […] The existing evidence on exercise and PD suggests that exercise should be prescribed along relevant medication to pwPD as early as possible. […] Also, given the safety and feasibility of exercise in PD there appears to be no harm in prescribing exercise for those at risk of developing PD (ie, rapid eye movement sleep behaviour disorder, genetic predisposition) to reduce the risk of developing PD or potentially prolong the time to diagnosis.

• #69 A Comprehensive Guide to Fall Prevention for Parkinson’s Disease – Living Well Balanced

  https://wellbalancedchiropractic.com/a-comprehensive-guide-to-fall-prevention-for-people-with-parkinsons-disease/

  A Comprehensive Guide to Fall Prevention for Parkinson’s Disease […] Parkinson’s disease is a chronic and progressive neurological disorder that affects the movement of the body. One of the common symptoms of Parkinson’s disease is a gait disturbance, which can lead to a higher risk of falls. According to the National Institute of Health, up to 60% of people with Parkinson’s disease will fall each year. However, there are steps that people with Parkinson’s disease can take to reduce their risk of falls. […] Keep reading to learn about methods to prevent falling for people with Parkinson’s disease! […] 1. Physical Therapy […] Physical therapy can help people with Parkinson’s disease to improve their balance, strength, and flexibility. A physical therapist can also teach people with Parkinson’s disease how to walk more safely and efficiently. Our Physical Therapists have 1-on-1 sessions that are completely tailored to the individual’s specific needs and abilities.

• #70 A Comprehensive Guide to Fall Prevention for Parkinson’s Disease – Living Well Balanced

  https://wellbalancedchiropractic.com/a-comprehensive-guide-to-fall-prevention-for-people-with-parkinsons-disease/

  A Comprehensive Guide to Fall Prevention for Parkinson’s Disease […] Parkinson’s disease is a chronic and progressive neurological disorder that affects the movement of the body. One of the common symptoms of Parkinson’s disease is a gait disturbance, which can lead to a higher risk of falls. According to the National Institute of Health, up to 60% of people with Parkinson’s disease will fall each year. However, there are steps that people with Parkinson’s disease can take to reduce their risk of falls. […] Keep reading to learn about methods to prevent falling for people with Parkinson’s disease! […] 1. Physical Therapy […] Physical therapy can help people with Parkinson’s disease to improve their balance, strength, and flexibility. A physical therapist can also teach people with Parkinson’s disease how to walk more safely and efficiently. Our Physical Therapists have 1-on-1 sessions that are completely tailored to the individual’s specific needs and abilities.

• #71 A Comprehensive Guide to Fall Prevention for Parkinson’s Disease – Living Well Balanced

  https://wellbalancedchiropractic.com/a-comprehensive-guide-to-fall-prevention-for-people-with-parkinsons-disease/

  2. Medication Management […] Medication management is crucial for people with Parkinson’s disease. Some medications used to treat Parkinson’s disease can cause dizziness, drowsiness, and confusion, which can increase the risk of falls. It is important to work closely with a healthcare provider to adjust medication dosages or change medications if necessary. […] 3. Home Modifications […] Home modifications can help people with Parkinson’s disease to prevent falls. Occupational therapists (OTs) are trained to help individuals perform activities of daily living (ADLs) and instrumental activities of daily living (IADLs) in their home environment. One way OTs can assist with this is through home modifications. Home modifications involve making changes to a person’s home environment to make it safer and more accessible! Some modifications that can be made include: Removing clutter and tripping hazards from floors, Installing grab bars in bathrooms and other areas of the home where support is needed, Adding non-slip mats to the shower and bathtub, Installing handrails on staircases.

• #72 A Comprehensive Guide to Fall Prevention for Parkinson’s Disease – Living Well Balanced

  https://wellbalancedchiropractic.com/a-comprehensive-guide-to-fall-prevention-for-people-with-parkinsons-disease/

  4. Footwear […] Wearing appropriate footwear is important for fall prevention in people with Parkinson’s disease. Shoes should fit well and have good support and traction. Orthotics may be what you need! Orthotics are medical devices that a podiatrist or specialist prescribes to their patient. You place them in your shoes to adjust how your feet move and how you distribute your weight and help alleviate any unnecessary pressure and adjust awkward muscle usage. Be sure to consult a doctor to see if Orthotics are a right fit for you! […] 5. Assistive Devices […] Assistive devices can be helpful for people with Parkinson’s disease to prevent falls. Devices such as canes, walkers, and wheelchairs can provide support and stability when walking. These devices should be prescribed and fitted by a healthcare professional.

• #73 A Comprehensive Guide to Fall Prevention for Parkinson’s Disease – Living Well Balanced

  https://wellbalancedchiropractic.com/a-comprehensive-guide-to-fall-prevention-for-people-with-parkinsons-disease/

  6. Exercise […] Regular exercise can help people with Parkinson’s disease to improve their balance, strength, and flexibility. Our Rocksteady Boxing trainers tailor each exercise to the individual’s abilities and goals. Rock Steady Boxing is a non-profit organization that provides fitness programs and instruction. The goal of the organization is to help people with Parkinson’s disease improve their quality of life. At Living Well Balanced, we offer the Rock Steady Boxing program as one of our treatments for Parkinson’s disease. The program uses non-contact boxing to build fitness and fight back against the deterioration of motor skills, balance, and sensory function. […] In conclusion, falls can be a significant concern for people with Parkinson’s disease. However, by taking steps such as physical therapy, medication management, home modifications, appropriate footwear, assistive devices, and exercise, people with Parkinson’s disease can reduce their risk of falls and maintain their independence. It is important to work closely with a healthcare provider to develop a personalized fall prevention plan!

• #74 A Comprehensive Guide to Fall Prevention for Parkinson’s Disease – Living Well Balanced

  https://wellbalancedchiropractic.com/a-comprehensive-guide-to-fall-prevention-for-people-with-parkinsons-disease/

  A Comprehensive Guide to Fall Prevention for Parkinson’s Disease […] Parkinson’s disease is a chronic and progressive neurological disorder that affects the movement of the body. One of the common symptoms of Parkinson’s disease is a gait disturbance, which can lead to a higher risk of falls. According to the National Institute of Health, up to 60% of people with Parkinson’s disease will fall each year. However, there are steps that people with Parkinson’s disease can take to reduce their risk of falls. […] Keep reading to learn about methods to prevent falling for people with Parkinson’s disease! […] 1. Physical Therapy […] Physical therapy can help people with Parkinson’s disease to improve their balance, strength, and flexibility. A physical therapist can also teach people with Parkinson’s disease how to walk more safely and efficiently. Our Physical Therapists have 1-on-1 sessions that are completely tailored to the individual’s specific needs and abilities.

• #75 A Comprehensive Guide to Fall Prevention for Parkinson’s Disease – Living Well Balanced

  https://wellbalancedchiropractic.com/a-comprehensive-guide-to-fall-prevention-for-people-with-parkinsons-disease/

  2. Medication Management […] Medication management is crucial for people with Parkinson’s disease. Some medications used to treat Parkinson’s disease can cause dizziness, drowsiness, and confusion, which can increase the risk of falls. It is important to work closely with a healthcare provider to adjust medication dosages or change medications if necessary. […] 3. Home Modifications […] Home modifications can help people with Parkinson’s disease to prevent falls. Occupational therapists (OTs) are trained to help individuals perform activities of daily living (ADLs) and instrumental activities of daily living (IADLs) in their home environment. One way OTs can assist with this is through home modifications. Home modifications involve making changes to a person’s home environment to make it safer and more accessible! Some modifications that can be made include: Removing clutter and tripping hazards from floors, Installing grab bars in bathrooms and other areas of the home where support is needed, Adding non-slip mats to the shower and bathtub, Installing handrails on staircases.

• #76 A Comprehensive Guide to Fall Prevention for Parkinson’s Disease – Living Well Balanced

  https://wellbalancedchiropractic.com/a-comprehensive-guide-to-fall-prevention-for-people-with-parkinsons-disease/

  4. Footwear […] Wearing appropriate footwear is important for fall prevention in people with Parkinson’s disease. Shoes should fit well and have good support and traction. Orthotics may be what you need! Orthotics are medical devices that a podiatrist or specialist prescribes to their patient. You place them in your shoes to adjust how your feet move and how you distribute your weight and help alleviate any unnecessary pressure and adjust awkward muscle usage. Be sure to consult a doctor to see if Orthotics are a right fit for you! […] 5. Assistive Devices […] Assistive devices can be helpful for people with Parkinson’s disease to prevent falls. Devices such as canes, walkers, and wheelchairs can provide support and stability when walking. These devices should be prescribed and fitted by a healthcare professional.

• #77 A Comprehensive Guide to Fall Prevention for Parkinson’s Disease – Living Well Balanced

  https://wellbalancedchiropractic.com/a-comprehensive-guide-to-fall-prevention-for-people-with-parkinsons-disease/

  6. Exercise […] Regular exercise can help people with Parkinson’s disease to improve their balance, strength, and flexibility. Our Rocksteady Boxing trainers tailor each exercise to the individual’s abilities and goals. Rock Steady Boxing is a non-profit organization that provides fitness programs and instruction. The goal of the organization is to help people with Parkinson’s disease improve their quality of life. At Living Well Balanced, we offer the Rock Steady Boxing program as one of our treatments for Parkinson’s disease. The program uses non-contact boxing to build fitness and fight back against the deterioration of motor skills, balance, and sensory function. […] In conclusion, falls can be a significant concern for people with Parkinson’s disease. However, by taking steps such as physical therapy, medication management, home modifications, appropriate footwear, assistive devices, and exercise, people with Parkinson’s disease can reduce their risk of falls and maintain their independence. It is important to work closely with a healthcare provider to develop a personalized fall prevention plan!

• #78 Fall Prevention Strategies for People With Parkinson’s

  https://elementpt.com/fall-prevention-strategies-for-people-with-parkinsons/

  Falls are one of the most common causes of injury among people with Parkinsons Disease. […] The good news is that the help of our highly trained neurological physical therapist can prevent a lot of falls. […] Research has shown that people with neurological disorders like Parkinsons who exercise regularly experience less stiffness and a reduction in and even reversal of dysfunction. […] Research also has shown that exercise can improve gait, balance, tremors, flexibility, grip strength, and motor coordination in patients with Parkinsons Disease. […] Evidence has shown that people with Parkinsons that participate in exercise programs for longer than six months, regardless of exercise intensity, have significant gains in functional balance and mobility.

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