Mięśniaki macicy
Leczenie
Mięśniaki macicy, występujące u 70-80% kobiet do 50. roku życia, to łagodne guzy mięśniówki macicy, które często przebiegają bezobjawowo i nie wymagają leczenia. W przypadku objawów takich jak obfite krwawienia miesiączkowe, ból miednicy czy problemy z płodnością, terapia powinna być indywidualizowana, uwzględniając wiek, wielkość, liczbę i lokalizację mięśniaków oraz plany reprodukcyjne pacjentki. Dostępne opcje terapeutyczne obejmują leczenie hormonalne (np. doustne środki antykoncepcyjne, agoniści i antagoniści GnRH, selektywne modulatory receptora progesteronowego), metody małoinwazyjne (embolizacja tętnic macicznych z redukcją objętości mięśniaków o 30-50%, ablacja endometrium, ablacja radiofalowa z redukcją do 66% po roku, MRgFUS) oraz leczenie chirurgiczne (miomektomia z zachowaniem macicy lub histerektomia). Agoniści GnRH mogą zmniejszyć objętość mięśniaków nawet o 50% po 3 miesiącach, jednak ich stosowanie jest ograniczone do 3-6 miesięcy ze względu na ryzyko utraty masy kostnej. Antagoniści GnRH (relugolix, elagolix) oraz selektywne modulatory receptora progesteronowego (ulipristal octan) oferują skuteczną kontrolę objawów z mniejszą liczbą działań niepożądanych.
- Leczenie mięśniaków macicy – wprowadzenie
- Obserwacja kliniczna (watchful waiting)
- Leczenie farmakologiczne
- Preparaty hormonalne antykoncepcyjne
- Wkładka wewnątrzmaciczna uwalniająca lewonorgestrel
- Agoniści hormonu uwalniającego gonadotropinę (GnRH)
- Antagoniści GnRH
- Inne leki
- Zabiegi małoinwazyjne
- Embolizacja tętnic macicznych (UAE/UFE)
- Ablacja endometrium
- Ablacja radiofalowa pod kontrolą USG
- MRgFUS – zogniskowane ultradźwięki pod kontrolą rezonansu magnetycznego
- Leczenie chirurgiczne
- Porównanie skuteczności metod leczenia mięśniaków macicy
- Leczenie mięśniaków a zachowanie płodności
- Nowe kierunki w leczeniu mięśniaków macicy
- Podsumowanie zaleceń dotyczących leczenia mięśniaków macicy
Leczenie mięśniaków macicy – wprowadzenie
Mięśniaki macicy to łagodne guzy rozwijające się w mięśniówce macicy, występujące u około 70-80% kobiet do 50. roku życia. Często nie powodują one żadnych objawów i nie wymagają leczenia. Jednak, gdy mięśniaki wywołują dolegliwości takie jak obfite krwawienia miesiączkowe, ból miednicy, uczucie parcia lub problemy z płodnością, konieczne jest wdrożenie odpowiedniego leczenia.12
Wybór metody leczenia mięśniaków macicy powinien być zindywidualizowany i zależy od wielu czynników, takich jak: wiek pacjentki, nasilenie objawów, wielkość, liczba i lokalizacja mięśniaków, plany dotyczące zachowania płodności oraz preferencje pacjentki. Ważne jest, aby przed podjęciem decyzji o sposobie leczenia pacjentka poznała wszystkie dostępne opcje terapeutyczne.34
Obserwacja kliniczna (watchful waiting)
W przypadku bezobjawowych mięśniaków macicy lub tych powodujących jedynie łagodne dolegliwości, najlepszym rozwiązaniem może być obserwacja kliniczna bez aktywnego leczenia. Mięśniaki mogą rosnąć powoli lub wcale, a po menopauzie często ulegają zmniejszeniu lub zanikają całkowicie z powodu spadku poziomu estrogenów.56
Obserwacja kliniczna (tzw. watchful waiting) jest szczególnie wskazana u kobiet zbliżających się do menopauzy, ponieważ mięśniaki zwykle zmniejszają swoją objętość w tym okresie. Zaleca się wówczas regularne kontrole ginekologiczne z wykonaniem badania USG w celu monitorowania wzrostu mięśniaków.78
Leczenie farmakologiczne
Preparaty hormonalne antykoncepcyjne
Doustne środki antykoncepcyjne (tabletki, plastry lub pierścienie dopochwowe) zawierające kombinację estrogenu i progestagenu mogą pomóc w kontrolowaniu objawów mięśniaków macicy, szczególnie obfitych krwawień miesiączkowych i bólu. Nie zmniejszają one jednak wielkości mięśniaków ani nie zapobiegają ich wzrostowi. Są to leki pierwszego wyboru, ponieważ mogą być stosowane długoterminowo, są dobrze tolerowane, stosunkowo niedrogie i zapewniają dodatkowe korzyści, takie jak zmniejszenie ryzyka raka jajnika i endometrium.910
Wkładka wewnątrzmaciczna uwalniająca lewonorgestrel
Wkładka wewnątrzmaciczna uwalniająca lewonorgestrel (Mirena) może być skuteczna w leczeniu objawów związanych z mięśniakami, zwłaszcza obfitych krwawień miesiączkowych. Progestagen zawarty w wkładce powoduje ścieńczenie błony śluzowej macicy, co prowadzi do zmniejszenia krwawień. Należy jednak pamiętać, że w przypadku dużych mięśniaków lub tych zniekształcających jamę macicy istnieje zwiększone ryzyko wypadnięcia wkładki.1112
Agoniści hormonu uwalniającego gonadotropinę (GnRH)
Agoniści GnRH (np. leuprorelin, goserelina) powodują obniżenie poziomu estrogenów i progesteronu, wprowadzając organizm w stan zbliżony do sztucznej menopauzy. Prowadzi to do zmniejszenia objętości mięśniaków nawet o 50% po trzech miesiącach terapii. Leki te są szczególnie przydatne przed planowanym zabiegiem operacyjnym, ponieważ zmniejszają wielkość mięśniaków, ułatwiając ich usunięcie, a także poprawiają parametry morfologii krwi u pacjentek z anemią.1314
Niestety, długotrwałe stosowanie agonistów GnRH może prowadzić do utraty masy kostnej, dlatego ich użycie jest zwykle ograniczone do 3-6 miesięcy. Po zakończeniu leczenia następuje szybki nawrót mięśniaków i przywrócenie objętości macicy do wartości sprzed leczenia.1516
Antagoniści GnRH
Nową grupę leków stanowią antagoniści GnRH (np. relugolix, elagolix), które blokują receptory GnRH, prowadząc do szybkiego obniżenia poziomu estrogenów i progesteronu. Leki te zmniejszają objawy związane z mięśniakami, szczególnie obfite krwawienia miesiączkowe. Na rynku dostępne są dwa doustne preparaty antagonistów GnRH zatwierdzone przez FDA do leczenia obfitych krwawień miesiączkowych związanych z mięśniakami: Myfembree (relugolix-estradiol-noretyndron) oraz Oriahnn (elagolix-estradiol-noretyndron).1718
Inne leki
Selektywne modulatory receptora progesteronowego (SPRM) – Substancje takie jak ulipristal octan wpływają na receptory progesteronu, zmniejszając objętość mięśniaków i kontrolując krwawienia. Od lutego 2012 roku ulipristal octan jest zarejestrowany do przedoperacyjnego leczenia mięśniaków. Główną zaletą ulipristalu w porównaniu z agonistami GnRH jest mniejsza częstość występowania działań niepożądanych.19
Niesteroidowe leki przeciwzapalne (NLPZ) – Leki takie jak ibuprofen czy naproksen mogą zmniejszać ból i skurcze związane z mięśniakami poprzez blokowanie określonych hormonów odpowiedzialnych za skurcze. Nie zmniejszają one jednak wielkości mięśniaków i nie powinny być stosowane w wysokich dawkach przez dłuższy czas.2021
Kwas traneksamowy (Lysteda) – Jest to lek przeciwfibrynolityczny, który pomaga w krzepnięciu krwi, zmniejszając tym samym obfitość krwawienia miesiączkowego. Nie wpływa na wielkość mięśniaków, ale może znacząco zmniejszyć objawy krwotoczne.2223
Zabiegi małoinwazyjne
Embolizacja tętnic macicznych (UAE/UFE)
Embolizacja tętnic macicznych (UAE – Uterine Artery Embolization lub UFE – Uterine Fibroid Embolization) to małoinwazyjna procedura, podczas której przez małe nacięcie w pachwinie lub nadgarstku wprowadza się cewnik do tętnic macicznych. Następnie wstrzykuje się drobne cząsteczki, które blokują dopływ krwi do mięśniaków, powodując ich obumieranie i zmniejszenie objętości o około 30-50%.2425
Procedura ta jest skuteczna w zmniejszaniu objawów takich jak obfite krwawienia i dolegliwości bólowe. Badania wykazały, że blisko 90% pacjentek poddanych embolizacji tętnic macicznych doświadcza znacznej poprawy lub całkowitego ustąpienia objawów związanych z mięśniakami. Zaletą tej metody jest krótki czas rekonwalescencji, brak konieczności hospitalizacji i zachowanie macicy. Po zabiegu UAE mięśniaki mogą ponownie odrosnąć lub unaczyniać się, a do 20% kobiet poszukuje dodatkowych metod leczenia w ciągu pięciu lat po zabiegu.2627
Embolizacja tętnic macicznych może być dobrą opcją dla kobiet, które chcą uniknąć operacji, mają ograniczoną możliwość operacyjną lub przebyły wiele zabiegów w obrębie jamy brzusznej. Należy jednak zaznaczyć, że zabieg ten nie jest zalecany u kobiet planujących ciążę, gdyż może wpływać na funkcję jajników i macicy.2829
Ablacja endometrium
Ablacja endometrium to zabieg polegający na zniszczeniu błony śluzowej macicy przy użyciu różnych technik, takich jak laser, prąd elektryczny, zamrażanie, mikrofale lub balon termiczny. Procedura ta nie zmniejsza wielkości mięśniaków, ale może znacząco zredukować obfite krwawienia miesiączkowe związane z mięśniakami.3031
Zabieg ten jest zalecany głównie kobietom, które zakończyły już plany rozrodcze, ponieważ wpływa na płodność. Ablacja endometrium jest skuteczna w przypadku małych mięśniaków zlokalizowanych blisko błony śluzowej macicy. Po zabiegu większość kobiet doświadcza znacznego zmniejszenia krwawień lub całkowitego ich ustąpienia.3233
Ablacja radiofalowa pod kontrolą USG
Istnieją dwie techniki ablacji radiofalowej pod kontrolą USG: laparoskopowa (np. Acessa) i przezszyjkowa (np. Sonata). Podczas tych zabiegów wykorzystuje się energię o częstotliwości radiowej do niszczenia tkanki mięśniaków. Procedura Acessa wykonywana jest laparoskopowo przez małe nacięcia w powłokach brzusznych, natomiast system Sonata wykorzystuje sondę ultrasonograficzną wprowadzoną do macicy w celu zlokalizowania i ablacji mięśniaków.3435
Po roku od zabiegu objętość mięśniaków zmniejsza się nawet o 66%, co prowadzi do znacznego zmniejszenia bólu miednicy, obfitych miesiączek i objawów uciskowych. Zabiegi te są małoinwazyjne, wykonywane w trybie ambulatoryjnym i pozwalają na szybki powrót do normalnej aktywności. Należy jednak ostrożnie podchodzić do tych metod u kobiet planujących ciążę.3637
MRgFUS – zogniskowane ultradźwięki pod kontrolą rezonansu magnetycznego
MRgFUS (Magnetic Resonance-guided Focused Ultrasound Surgery) to nieinwazyjna metoda leczenia mięśniaków, która wykorzystuje fale ultradźwiękowe o wysokiej częstotliwości do niszczenia tkanki mięśniaka pod kontrolą rezonansu magnetycznego. Procedura ta nie wymaga nacięć, dzięki czemu nie pozostawia blizn i charakteryzuje się minimalnym ryzykiem powikłań.3839
Zabieg MRgFUS trwa około 3 godzin i jest wykonywany w trybie ambulatoryjnym. Pacjentki mogą wrócić do normalnej aktywności w ciągu jednego dnia po zabiegu. Chociaż mięśniaki są leczone i ostatecznie zmniejszają swoją wielkość, nie są usuwane. Długoterminowa skuteczność tej metody nie jest jeszcze w pełni poznana, a zabieg nie jest zalecany kobietom, które chcą zachować płodność.4041
Leczenie chirurgiczne
Miomektomia
Miomektomia to zabieg chirurgiczny polegający na usunięciu mięśniaków z zachowaniem macicy. Jest to operacja z wyboru u kobiet, które planują w przyszłości ciążę lub chcą zachować macicę z innych powodów. W zależności od rozmiaru, liczby i lokalizacji mięśniaków, miomektomia może być wykonana różnymi technikami:4243
- Miomektomia histeroskopowa – wykonywana przez pochwę i szyjkę macicy za pomocą histeroskopu (cienkiego teleskopu) w przypadku mięśniaków podśluzówkowych znajdujących się w jamie macicy. Nie wymaga nacięć, jest zabiegiem ambulatoryjnym, a większość kobiet może wrócić do normalnej aktywności w ciągu kilku dni.4445
- Miomektomia laparoskopowa lub robotyczna – przeprowadzana przez kilka małych nacięć w powłokach brzusznych (5-10 mm), czasami z użyciem robota chirurgicznego, zalecana w przypadku mniejszej liczby mięśniaków.4647
- Miomektomia brzuszna (laparotomia) – wykonywana przez jedno lub dwa nacięcia w jamie brzusznej, zalecana przy dużych lub licznych mięśniakach. Wymaga dłuższego pobytu w szpitalu (1-4 dni) i czasu rekonwalescencji (4-6 tygodni).48
Po miomektomii, niezależnie od metody, istnieje ryzyko odrostu mięśniaków. Około 10-25% pacjentek poddanych miomektomii będzie potrzebowało drugiej operacji mięśniaków w ciągu życia rozrodczego.4950
Histerektomia
Histerektomia to operacja polegająca na całkowitym usunięciu macicy. Jest to jedyna metoda, która daje trwałe rozwiązanie problemu mięśniaków i zapobiega ich nawrotom. Po histerektomii pacjentka nie może już zajść w ciążę, dlatego ta opcja jest zwykle oferowana kobietom, które zakończyły plany rozrodcze lub nie planują posiadania dzieci.5152
W zależności od wielkości mięśniaków i indywidualnych uwarunkowań pacjentki, histerektomia może być wykonana różnymi metodami:5354
- Histerektomia pochwowa – macica usuwana jest przez pochwę, bez nacięć w powłokach brzusznych.
- Histerektomia laparoskopowa – wykonywana przez kilka małych nacięć w powłokach brzusznych, czasem wspomagana robotem chirurgicznym.
- Histerektomia brzuszna – wykonywana przez duże nacięcie w powłokach brzusznych, zalecana przy bardzo dużych mięśniakach.
Histerektomia przezbrzuszna wiąże się z dłuższym czasem rekonwalescencji, zwiększoną utratą krwi i wyższym ryzykiem infekcji w porównaniu z metodami małoinwazyjnymi. Podczas histerektomii z powodu mięśniaków jajniki zwykle pozostają zachowane, co pozwala uniknąć objawów menopauzy u kobiet przed naturalną menopauzą.5556
Porównanie skuteczności metod leczenia mięśniaków macicy
Wybór optymalnej metody leczenia mięśniaków macicy zależy od wielu czynników, a każda z dostępnych opcji ma swoje zalety i ograniczenia. Poniżej przedstawiono porównanie skuteczności różnych metod terapeutycznych:5758
| Metoda leczenia | Skuteczność w redukcji objawów | Zmniejszenie wielkości mięśniaków | Zachowanie płodności | Ryzyko nawrotu | Czas rekonwalescencji |
|---|---|---|---|---|---|
| Leczenie hormonalne | Umiarkowana | Czasowe (agoniści GnRH) | Tak | Wysokie | Brak |
| Embolizacja tętnic macicznych (UAE/UFE) | Wysoka (ok. 90%) | 30-50% | Możliwe, ale nie zalecane | Umiarkowane (20% w ciągu 5 lat) | 1-2 tygodnie |
| Ablacja endometrium | Wysoka dla krwawień | Brak | Nie | Niskie dla krwawień | Kilka dni |
| Ablacja radiofalowa (Acessa, Sonata) | Wysoka (>90%) | Do 66% po roku | Możliwe, ale ograniczone | Umiarkowane | 1-2 tygodnie |
| MRgFUS | Umiarkowana do wysokiej | Tak | Tak | Umiarkowane | 1-2 dni |
| Miomektomia | Wysoka | Całkowite usunięcie | Tak | 10-25% w ciągu życia rozrodczego | 2-6 tygodni (zależnie od metody) |
| Histerektomia | Całkowita | Całkowite usunięcie | Nie | Brak | 2-8 tygodni (zależnie od metody) |
Leczenie mięśniaków a zachowanie płodności
Dla kobiet, które planują posiadanie dzieci w przyszłości, zachowanie płodności jest kluczowym aspektem wyboru metody leczenia mięśniaków. Mięśniaki mogą wpływać na zdolność do zajścia w ciążę z różnych powodów, na przykład gdy znajdują się w miejscu w macicy, gdzie powinien zagnieździć się zarodek.5960
W przypadku kobiet planujących ciążę, najlepszą opcją leczenia mięśniaków powodujących objawy jest zazwyczaj miomektomia. Zabieg ten pozwala na usunięcie mięśniaków przy jednoczesnym zachowaniu macicy. Po miomektomii macica potrzebuje czasu na zagojenie, zwykle od 1 do 6 miesięcy przed próbą zajścia w ciążę.6162
Inne metody zachowujące macicę, takie jak MRgFUS, również mogą być rozważane u kobiet planujących ciążę. Istnieją doniesienia o udanych ciążach po leczeniu mięśniaków tą metodą. Należy jednak zachować ostrożność w przypadku embolizacji tętnic macicznych (UAE), ponieważ może ona wpływać na funkcję jajników i upośledzać płodność. Zabieg ten nie jest zalecany przez FDA kobietom planującym ciążę.6364
Leczenie hormonalne, takie jak agoniści GnRH, może być stosowane przed zabiegiem operacyjnym w celu zmniejszenia mięśniaków, ale nie ma danych potwierdzających poprawę wskaźników ciąż lub porodów po leczeniu. Po zakończeniu leczenia hormonalnego należy odczekać z próbą zajścia w ciążę do powrotu normalnych cykli miesiączkowych.65
Nowe kierunki w leczeniu mięśniaków macicy
Badania nad nowymi metodami leczenia mięśniaków macicy są obecnie intensywnie prowadzone. Jednym z obiecujących kierunków jest opracowanie nowych leków, które będą leczyć same mięśniaki, a nie tylko ich objawy.6667
Na Uniwersytecie Duke i Uniwersytecie Stanowym Karoliny Północnej trwają prace nad nową terapią wykorzystującą kombinację LiquoGel i kolagenazy, która może być podawana w gabinecie lekarskim i działa tylko na sam guz. Z czasem kolagenaza rozkłada i zmiękcza tkankę mięśniaka. Zespół badawczy uzyskał finansowanie na dalsze badania, które mają umożliwić przeprowadzenie badań klinicznych i ostatecznie uzyskanie autoryzacji FDA.68
Innym kierunkiem badań jest ocena skuteczności i bezpieczeństwa nowych metod małoinwazyjnych, takich jak przezszyjkowa ablacja radiofalowa mięśniaków (system Sonata). W badaniu opublikowanym w Journal of Gynecologic Surgery, obejmującym 147 kobiet poddanych leczeniu systemem Sonata, 94% było zadowolonych z leczenia, a 88% zgłosiło zmniejszenie objawów mięśniaków po trzech latach.69
Centrum Leczenia Mięśniaków Macicy przy NYU Langone aktywnie angażuje się w badania mające na celu poprawę leczenia mięśniaków. Prowadzony jest tam program LIFE (Lifestyle Intervention with Fibroid Education), którego celem jest zbadanie, czy modyfikacja stylu życia może wpłynąć na nawroty mięśniaków.70
Podsumowanie zaleceń dotyczących leczenia mięśniaków macicy
Leczenie mięśniaków macicy powinno być zindywidualizowane i zależeć od wielu czynników, w tym wieku pacjentki, nasilenia objawów, wielkości i lokalizacji mięśniaków oraz planów dotyczących zachowania płodności. Poniżej przedstawiono ogólne zalecenia dotyczące wyboru metody leczenia w różnych sytuacjach klinicznych:7172
- U pacjentek bezobjawowych zaleca się obserwację kliniczną bez aktywnego leczenia, z regularnym monitorowaniem wielkości mięśniaków.73
- U pacjentek z objawami krwotocznymi (obfite lub przedłużone miesiączki) można zastosować leczenie hormonalne (tabletki antykoncepcyjne, wkładka z lewonorgestrelem) lub kwas traneksamowy.74
- U pacjentek z objawami uciskowymi (ból, uczucie parcia) skuteczne może być leczenie operacyjne lub małoinwazyjne.75
- U pacjentek planujących ciążę najlepszą opcją jest miomektomia, która pozwala na usunięcie mięśniaków z zachowaniem macicy.76
- U pacjentek zbliżających się do menopauzy można rozważyć krótkotrwałe leczenie agonistami GnRH lub obserwację kliniczną, ponieważ mięśniaki zwykle maleją po menopauzie.77
- U pacjentek, które zakończyły plany rozrodcze, histerektomia jest jedyną metodą trwale eliminującą problem mięśniaków.78
- Embolizacja tętnic macicznych (UAE) jest dobrą opcją dla pacjentek z przeciwwskazaniami do leczenia operacyjnego lub tych, które chcą zachować macicę, ale nie planują ciąży.79
Ważne jest, aby przed podjęciem decyzji o sposobie leczenia pacjentka została poinformowana o wszystkich dostępnych opcjach terapeutycznych, ich skuteczności, potencjalnych korzyściach i ryzyku. Interdyscyplinarne podejście, obejmujące współpracę ginekologów, radiologów interwencyjnych i lekarzy podstawowej opieki zdrowotnej, pozwala na opracowanie optymalnego planu leczenia dostosowanego do indywidualnych potrzeb pacjentki.8081
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Materiały źródłowe
- #1 Uterine Fibroids: Causes, Symptoms & Treatmenthttps://my.clevelandclinic.org/health/diseases/9130-uterine-fibroids
Uterine fibroids can cause a variety of symptoms like pain and heavy, irregular vaginal bleeding. Treatment for fibroids typically depends on your symptoms. […] Treatment for uterine fibroids can vary depending on the size, number and location of the fibroids, as well as what symptoms theyre causing. If you arent experiencing any symptoms from your fibroids, you may not need treatment. […] If youre experiencing symptoms from your fibroids including anemia from excess bleeding, moderate to severe pain or urinary tract and bowel problems youll need treatment to help. Your treatment plan will depend on a few factors, including: […] Treatment options for uterine fibroids can include: […] Medications can have side effects and some may not be a good fit for you. […] There are several factors to consider when talking about the different types of surgery for fibroid removal.
- #2 Fibroids: Types, Symptoms, Causes, Pregnancy, Treatmenthttps://www.healthline.com/health/uterine-fibroids
Fibroids may not need treatment if theyre small or dont produce symptoms. […] A doctor will develop a treatment plan based on your age, the size of your fibroids, and your overall health. You may receive a combination of treatments. […] Certain home remedies and natural treatments can have a positive effect on fibroids, including: acupuncture, exercises such as yoga, massage, Gui Zhi Fu Ling Tang, a traditional Chinese medicine formula, applying heat for cramps (avoid heat if you experience heavy bleeding). […] Medications to regulate your hormone levels may be prescribed to shrink the fibroids. […] GnRH antagonists also help to shrink fibroids. […] Other options that can help control bleeding and pain but wont shrink or eliminate fibroids include: over-the-counter anti-inflammatory pain relievers such as ibuprofen and naproxen, birth control pills, an intrauterine device (IUD) that releases the hormone progestin.
- #3 The Conservative and Interventional Treatment of Fibroidshttps://pmc.ncbi.nlm.nih.gov/articles/PMC4298239/
Fibroids are the most common benign tumors in women. One-third of all women of reproductive age undergo treatment for symptomatic fibroids. In recent years, the spectrum of available treatments has been widened by the introduction of new drugs and interventional procedures. […] Fibroids can be treated with drugs, interventional procedures (uterine artery embolization [UAE] and focused ultrasound treatment [FUS]), and surgery. The evidence regarding the various available treatments is mixed. All methods improve symptoms, but only a few comparative studies have been performed. […] Multiple treatment options are available and enable individualized therapy for symptomatic fibroids. The most important considerations in the choice of treatment are the question of family planning and, in some cases, the technical limitations of the treatments themselves.
- #4 The Conservative and Interventional Treatment of Fibroidshttps://pmc.ncbi.nlm.nih.gov/articles/PMC4298239/
In women with symptomatic fibroids, drug therapy, surgical therapy now as minimally invasive operations whether organ-preserving or in the form of hysterectomy, and other interventional techniques such as uterine artery embolization (UAE) and fibroid treatment using highly focused ultrasound (FUS) can be offered. […] The evidence base relating to these various therapies is heterogeneous. In particular, there is not enough evidence from randomized controlled trials (RCTs) to form a judgment about whether fertility is improved after enucleation of fibroids. By contrast, alleviation of symptoms and improvement in quality of life after medical and surgical treatment and UAE are very well supported by evidence from randomized studies and meta-analyses. […] The primary indication for drug therapy is pretreatment before surgery. There are no studies showing improved pregnancy or birth rates.
- #5 Patient education: Uterine fibroids (Beyond the Basics) – UpToDatehttps://www.uptodate.com/contents/uterine-fibroids-beyond-the-basics/print
Fibroids are growths of the uterus. Treatments are available for fibroid-related problems like heavy menstrual bleeding, pain or pressure in the pelvis, or problems with pregnancy or infertility. […] If your fibroids are not causing bothersome symptoms, you can choose not to have treatment. If you do have symptoms, your options include observation, medication, or surgical treatment. The best treatment depends on which symptom(s) is most bothersome to you. […] Most medications aim to reduce the heavy menstrual bleeding that is common in people with fibroids. A few also shrink the fibroid, and some are focused on reducing pain or correcting anemia. Medications are often recommended before surgical treatments. […] Your doctor might recommend a surgical or interventional treatment for fibroids if: You have fibroid-related heavy menstrual bleeding, pain, or pressure that does not get better with medication; You are trying to get pregnant and fibroids appear to be interfering; The size of the fibroid is causing symptoms.
- #6https://www.aurorahealthcare.org/services/womens-health/services-treatments/uterine-fibroids
Uterine fibroids are noncancerous pelvic tumors located in the muscle of the uterus. […] If fibroids are causing you pain, discomfort, excessive bleeding or other symptoms, treatment is available. We offer a variety of minimally invasive fibroid treatment choices from medication and embolization to minimally invasive surgery. […] If fibroid treatment is necessary, your doctor may refer you to a fibroid specialist near you or recommend you visit the Aurora Fibroid Center at Aurora Sinai Medical Center in Milwaukee. […] Today, a wide range of treatment options are available, including medication and minimally invasive procedures. […] The most common fibroid treatment options include: Hormonal and non-hormonal medications, Uterine artery embolization (UAE), which stops blood flow to the uterus and fibroids, Hysteroscopic myomectomy, which removes fibroids with the help of a tiny camera that allows your doctor to see inside your uterus without making any incisions, Laparoscopic myomectomy, which removes fibroids through small incisions near your belly button or bikini line using a laparoscope, Minimally invasive hysterectomy, which removes all or part of the uterus through small incisions made in the abdomen, Laparoscopic radiofrequency ablation with Acessa, which softens and shrinks fibroid tissues through two small abdominal incisions using controlled radiofrequency energy, allowing you to avoid a hysterectomy and return to your life sooner.
- #7 Uterine Fibroids: Diagnosis and Treatment | AAFPhttps://www.aafp.org/pubs/afp/issues/2017/0115/p100.html
Uterine fibroids are common benign neoplasms, with a higher prevalence in older women and in those of African descent. […] Expectant management is recommended for asymptomatic patients because most fibroids decrease in size during menopause. Management should be tailored to the size and location of fibroids; the patient’s age, symptoms, desire to maintain fertility, and access to treatment; and the experience of the physician. Medical therapy to reduce heavy menstrual bleeding includes hormonal contraceptives, tranexamic acid, and nonsteroidal anti-inflammatory drugs. Gonadotropin-releasing hormone agonists or selective progesterone receptor modulators are an option for patients who need symptom relief preoperatively or who are approaching menopause. Surgical treatment includes hysterectomy, myomectomy, uterine artery embolization, and magnetic resonance-guided focused ultrasound surgery.
- #8 Uterine Fibroids Treatment | Stanford Health Carehttps://stanfordhealthcare.org/medical-conditions/womens-health/uterine-fibroids/treatments.html
Most uterine fibroids are harmless, cause no symptoms, and shrink with menopause. But some fibroids are painful, press on other internal organs, bleed and cause anemia, or cause pregnancy problems. […] If you have a fibroid problem, there are several treatments to consider. What treatment you choose may depend on how bad your symptoms are and whether you want to preserve your fertility. […] If you have uterine fibroids but you have few or no symptoms, you don’t need treatment. Instead, your doctor will recommend watchful waiting. […] If you are nearing menopause, watchful waiting may be an option for you. […] If you have pain or heavy menstrual bleeding, it may be from a bleeding uterine fibroid. […] The following medicines are used to relieve heavy menstrual bleeding, anemia, or painful periods, but they don’t shrink fibroids: Nonsteroidal anti-inflammatory drugs (NSAIDs).
- #9 Uterine Fibroids | Wide Range of Treatment Options :: Minnesota Women’s Care OBGYN and Urogynecologyhttps://mnwcare.com/our-services/gynecology/fibroids-treatments
There are many surgical and non-surgical treatment options for fibroids. The best treatment approach depends on many factors including what symptoms you are experiencing, the size number and location of the fibroids, and whether you are interested in pregnancy or not, among others. Your doctor will work with you to tailor the best treatment plan for you. […] There are many treatment options for fibroids that do not involve removing the uterus. If you want surgical treatment for your fibroids but don’t want to undergo a hysterectomy, the procedures below are the ones we discuss with our patients at Minnesota Women’s Care. […] Combined estrogen-progestin contraceptives: These come in the form of a pill, patch, or ring, and known as traditional „OCPs.” They are usually the first line approach, as can be used long-term, are well-tolerated, are relatively inexpensive, and provide contraception and additional benefits including decreasing the risk of ovarian and endometrial cancers.
- #10https://www.nhs.uk/conditions/fibroids/treatment/
Treatment may not be necessary if you have fibroids but do not have any symptoms, or if you only have minor symptoms that are not significantly affecting your everyday activities. […] If you have fibroids that need treatment, a GP may recommend medicine to help relieve your symptoms. […] But you may need to see a gynaecologist (a specialist in the female reproductive system) for further medicine or surgery if these are ineffective. […] Medicines are available that can be used to reduce heavy periods, but they can be less effective the larger your fibroids are. […] If you’re still experiencing symptoms related to fibroids despite treatment with the above medicines, a GP can refer you to a gynaecologist. […] They may prescribe medicine called gonadotropin releasing hormone analogues (GnRHas) to help shrink your fibroids.
- #11 Fibroid Treatment Options – Brigham and Women’s Hospitalhttps://www.brighamandwomens.org/obgyn/infertility-reproductive-surgery/cysts-and-fibroids/non-surgical-fibroid-treatment
Other medical therapies including androgenic agents (e.g., danazol, gestrinone), progestins (e.g., medroxyprogesterone acetate, depomedroxyprogesterone acetate, norethindrone), Mirena IUD. Oral contraceptive pills have been used to control menorrhagia (prolonged and/or profuse blood flow) in women with leiomyomas, presumably by diminishing the endometrium (endometrial atrophy). Tranexamic acid (Lysteda) is an anti-fibrinolytic medication that does not contain hormones that can also be used to treat heavy bleeding. None of these medications decrease uterus or fibroid volume. […] Uterine fibroid embolization (UFE), also known as uterine artery embolization(UAE) is an alternative to surgery that involves placing a catheter through a small incision in the groin into an artery in the leg and guiding the catheter via x-ray pictures to the arteries of the uterus. Once there, the catheter is used to deliver agents that block off the blood vessels that feed the uterine fibroids.
- #12 How to treat uterine fibroids: What are my options | HealthPartners Bloghttps://www.healthpartners.com/blog/uterine-fibroids-treatment/
Its very important for your doctor to understand the severity of your symptoms because this will help determine how and when to treat your fibroids. There are several ways to remove or shrink uterine fibroids, but if your symptoms are nonexistent or mild, your doctor may recommend a more conservative treatment plan. […] Watchful waiting is just like it sounds. A doctor may suggest simply waiting to see how or if your fibroids progress in size, multiply or if your symptoms worsen. […] An IUD is primarily used for longer-term pregnancy prevention, but hormonal IUDs can also be used to help reduce fibroid-related symptoms like heavy bleeding and painful periods. […] While medications wont cause fibroids to go away completely on their own, some like oral birth control or nonsteroidal anti-inflammatories can reduce the severity of some fibroid symptoms, like pain and heavy bleeding during periods.
- #13 Fibroid Treatment Options – Brigham and Women’s Hospitalhttps://www.brighamandwomens.org/obgyn/infertility-reproductive-surgery/cysts-and-fibroids/non-surgical-fibroid-treatment
Medicines can help control fibroid-related symptoms. The most effective medications for the treatment of fibroids are gonadotropin releasing hormone agonists (GnRHa), (including Lupron, Synarel, Zoladex). GnRH agonists cause a low-estrogen (menopause-like) state which causes reduction size of the tumor and uterus. Uterine size has been shown to decrease approximately 50 percent after three months of therapy with these medications. […] Unfortunately, long term use of GnRH agonists can lead to bone loss, however when GnRH agonist treatment is stopped it is followed by a rapid regrowth of the fibroids and of the uterus to pre-treatment volume. Therefore the use of GnRH agonists alone for treatment of fibroids is usually limited to a short one to three month preoperative course to shrink the uterus in preparation for surgery or to improve anemia before surgery.
- #14https://myhealth.alberta.ca/Health/pages/conditions.aspx?hwid=tv7259
Use GnRH-a to shrink fibroids before surgery, to stop heavy bleeding, or to treat symptoms for a short time before menopause. […] GnRH-a therapy may be a good choice if you are close to menopause (when fibroids shrink), have heavy bleeding from fibroids, or are planning surgery. This medicine usually is not used to relieve fibroid symptoms only, because fibroids grow back fairly quickly after treatment stops. […] This medicine puts your body into a state like menopause for as long as you take it. This lowers your body’s estrogen. This estrogen decrease stops menstrual periods and stops the growth of and reduces the size of uterine fibroids. […] GnRH-a therapy is not usually used to relieve pain and bleeding only, because fibroids grow back fairly quickly after you stop taking GnRH-a. But it is sometimes used to shrink large fibroids before fibroid surgery or to stop heavy bleeding from fibroids.
- #15https://myhealth.alberta.ca/Health/pages/conditions.aspx?hwid=tv7259
For people who are close to menopause (when fibroids will shrink on their own), short-term relief from GnRH-a therapy can be a good choice. […] You have severe bleeding from uterine fibroids and need treatment right away. […] Other treatments for fibroids haven’t helped your symptoms, and you’re planning surgery later. […] You’re close to menopause, when fibroids will get smaller or go away. […] You’re planning to have surgery to take out large fibroids. […] You’re not planning on getting pregnant soon. […] GnRH-a can shrink fibroids before surgery to remove them. This makes fibroids easier to remove and can reduce the risk of bleeding during surgery and problems after surgery. […] GnRH-a can cause bone loss, so it is used for a limited amount of time. […] The medicine only treats fibroids for a while. Fibroids tend to grow back after you stop taking GnRH-a.
- #16 Fibroid Treatment Options – Brigham and Women’s Hospitalhttps://www.brighamandwomens.org/obgyn/infertility-reproductive-surgery/cysts-and-fibroids/non-surgical-fibroid-treatment
Medicines can help control fibroid-related symptoms. The most effective medications for the treatment of fibroids are gonadotropin releasing hormone agonists (GnRHa), (including Lupron, Synarel, Zoladex). GnRH agonists cause a low-estrogen (menopause-like) state which causes reduction size of the tumor and uterus. Uterine size has been shown to decrease approximately 50 percent after three months of therapy with these medications. […] Unfortunately, long term use of GnRH agonists can lead to bone loss, however when GnRH agonist treatment is stopped it is followed by a rapid regrowth of the fibroids and of the uterus to pre-treatment volume. Therefore the use of GnRH agonists alone for treatment of fibroids is usually limited to a short one to three month preoperative course to shrink the uterus in preparation for surgery or to improve anemia before surgery.
- #17 Uterine Fibroids | Wide Range of Treatment Options :: Minnesota Women’s Care OBGYN and Urogynecologyhttps://mnwcare.com/our-services/gynecology/fibroids-treatments
Progestins: Options include high dose oral progestins (norethindrone acetate or medroxyprogesterone acetate most commonly), a progestin injection („Depo provera,” administered every 6 months), the etonorgestrel arm implant („Nexplanon”), or the levonorgestrel intrauterine device (IUD). […] Gonadotropin-releasing hormone (Gn-RH) agonists and antagonists: These drugs block the production of ovarian-stimulating hormones, lowering estrogen levels. Since fibroids are estrogen responsive, this results in reduction of menstrual bleeding, and notably, some reduction in fibroid size. […] There are currently two oral Gn-RH agonists on the market that are FDA approved for fibroid related heavy menstrual bleeding: Myfembree (relugolix-estradiol-norethindrone) and Orianhh (elagolix-estradiol-norethindrone).
- #18 Shrink Them, Zap Them, Starve Them: Newer, Minimally Invasive Fibroid Treatments Offer Hysterectomy Alternative | NYU Langone Newshttps://nyulangone.org/news/shrink-them-zap-them-starve-them-newer-minimally-invasive-fibroid-treatments-offer-hysterectomy-alternative
Two U.S. Food and Drug Administration (FDA)approved fibroid medications: Oriahnn and Myfembree, have been shown to significantly reduce heavy menstrual bleeding associated with uterine fibroids. […] Uterine fibroid embolization is a minimally invasive outpatient procedure performed by an interventional radiologist. […] One of the most common fibroid procedures, myomectomy is a minimally invasive surgery that removes fibroids through the abdomen with tiny, thumb-size incisions. […] Transcervical fibroid ablation, often performed using the Sonata System, is one of the newest tools in fibroid treatment. […] In a study in the Journal of Gynecologic Surgery involving 147 women who had Sonata treatment, 94 percent were satisfied with the treatment and 88 percent reported reduced fibroid symptoms after three years. […] The Center for Fibroid Care is actively involved in research to improve fibroid management. […] Ultimately, we hope to better understand if LIFE can modify fibroid recurrence, says Dr. Shirazian.
- #19 The Conservative and Interventional Treatment of Fibroidshttps://pmc.ncbi.nlm.nih.gov/articles/PMC4298239/
Since February 2012, the SPRM ulipristal acetate has been licensed for pretreatment before scheduled surgery. The main advantage of ulipristal acetate over GnRH analogs (leuprorelin acetate) is the lower incidence of unwanted effects. […] UAE as a uterine-preserving form of treatment for symptomatic uterine fibroids has been available to women since 1989. Embolization of the uterine artery is a possible alternative to hysterectomy, especially in women with multiple fibroids, very large fibroids, restricted operability, or a history of multiple operative procedures in the abdomen. […] Fibroid embolization is a treatment procedure supported by evidence from randomized studies. […] Patients with symptomatic uterine fibroids can be offered a number of different treatment options. The choice of therapeutic technique depends first and foremost on whether the patient still wishes to bear children. For those who do, or who wish to retain their uterus, the methods of choice are hysteroscopic myomectomy for intracavitary and submucosal fibroids and laparoscopic enucleation for intramural or transmural fibroids although it must be mentioned that the evidence that fibroid enucleation carries any advantage for women who wish to preserve their fertility is thin. […] For women who do not wish to preserve their fertility, the minimally invasive hysterectomy techniques and uterine artery embolization are the treatments of choice.
- #20 Medical Therapy – Fibroids | UCLA Healthhttps://www.uclahealth.org/medical-services/fibroids/treatment-options/medical-therapy
This approach can provide an effective treatment for women nearing menopause who want to try medication for their symptoms. […] Instead of increasing estrogen and progesterone levels, these medications cause them to decrease. Menstruation then stops, fibroids shrink over several months and anemia (low red blood cells) often improves. […] Other medications treat fibroids without using hormones: […] Doctors use NSAIDs, a class of medication, to treat cramping and pain caused by fibroids. By targeting the specific hormones responsible for cramping, NSAIDs can help reduce symptoms. These medications do not shrink fibroids and should not be used at high doses for prolonged periods of time. […] TXA is a medication that works to help blood clotting. By boosting the bloods ability to clot, TXA helps decrease the amount of vaginal bleeding a woman experiences. […] Medical centers are studying additional medications for fibroid treatment, but for now, these are considered investigational (still in research).
- #21 Fibroids: Types, Symptoms, Causes, Pregnancy, Treatmenthttps://www.healthline.com/health/uterine-fibroids
Fibroids may not need treatment if theyre small or dont produce symptoms. […] A doctor will develop a treatment plan based on your age, the size of your fibroids, and your overall health. You may receive a combination of treatments. […] Certain home remedies and natural treatments can have a positive effect on fibroids, including: acupuncture, exercises such as yoga, massage, Gui Zhi Fu Ling Tang, a traditional Chinese medicine formula, applying heat for cramps (avoid heat if you experience heavy bleeding). […] Medications to regulate your hormone levels may be prescribed to shrink the fibroids. […] GnRH antagonists also help to shrink fibroids. […] Other options that can help control bleeding and pain but wont shrink or eliminate fibroids include: over-the-counter anti-inflammatory pain relievers such as ibuprofen and naproxen, birth control pills, an intrauterine device (IUD) that releases the hormone progestin.
- #22 Uterine Fibroids | Wide Range of Treatment Options :: Minnesota Women’s Care OBGYN and Urogynecologyhttps://mnwcare.com/our-services/gynecology/fibroids-treatments
Tranexamic acid („Lysteda”): This is a non-hormonal medication that works to slow down the breakdown of blood clots. In turn, slows down bleeding, and in this case can be used to reduce fibroid related bleeding. […] Essentially a myomectomy is a procedure where the fibroids are surgically removed from the uterus, and the uterine tissue is repaired. […] This procedure is generally recommended for pre-menopausal people who have symptomatic fibroids (bleeding or bulky) and wish to retain their uterus but do not intend for future pregnancy. […] Laparoscopic radiofrequency fibroid ablation (Lap-RFA, brand name Acessa) is a minimally invasive, energy-based treatment that reduces fibroid-related symptoms by reducing fibroid volume. […] After one year, the size of the fibroid decreases by up to 66%, resulting in a significant reduction in pelvic pain, heavy periods, and bulk. […] For this reason, should be used with caution if pregnancy is desired.
- #23 Treatment for Uterine Fibroids: Medication, Complementary Therapies, Surgery, and Morehttps://www.everydayhealth.com/womens-health/treatment-for-uterine-fibroids/
Myfembree is a combination of three medications: relugolix (a hormone blocker), estradiol (estrogen), and norethindrone acetate (a synthetic progesterone). It relieves heavy bleeding due to uterine fibroids. […] Pain relievers known as nonsteroidal anti-inflammatory drugs such as ibuprofen (Advil, Motrin) or naproxen (Aleve) may be prescribed to ease pain caused by fibroids. […] A drug called tranexamic acid (Lysteda), in a family of medicines known as antifibrinolytics, treats heavy bleeding. […] Doctors sometimes recommend OTC iron supplements to boost your red blood cell supply and address common anemia symptoms like weakness and fatigue. […] A variety of different complementary therapies for uterine fibroids can help to relieve symptoms such as discomfort from heavy bleeding and back pain.
- #24 Fibroid Treatment Options – Brigham and Women’s Hospitalhttps://www.brighamandwomens.org/obgyn/infertility-reproductive-surgery/cysts-and-fibroids/non-surgical-fibroid-treatment
Other medical therapies including androgenic agents (e.g., danazol, gestrinone), progestins (e.g., medroxyprogesterone acetate, depomedroxyprogesterone acetate, norethindrone), Mirena IUD. Oral contraceptive pills have been used to control menorrhagia (prolonged and/or profuse blood flow) in women with leiomyomas, presumably by diminishing the endometrium (endometrial atrophy). Tranexamic acid (Lysteda) is an anti-fibrinolytic medication that does not contain hormones that can also be used to treat heavy bleeding. None of these medications decrease uterus or fibroid volume. […] Uterine fibroid embolization (UFE), also known as uterine artery embolization(UAE) is an alternative to surgery that involves placing a catheter through a small incision in the groin into an artery in the leg and guiding the catheter via x-ray pictures to the arteries of the uterus. Once there, the catheter is used to deliver agents that block off the blood vessels that feed the uterine fibroids.
- #25 Uterine Fibroid Treatments, UFE, MRgFUShttps://www.radiologyinfo.org/en/info/uterine-fibroid-treatment
Uterine fibroid embolization (UFE) and magnetic resonance-guided focused ultrasound (MRgFUS) are minimally invasive procedures that doctors perform through the skin or through a tiny incision for patients with symptomatic uterine fibroids. […] Minimally invasive uterine fibroid treatments include: Uterine fibroid embolization (UFE) and Magnetic resonance-guided focused ultrasound (MRgFUS). […] Uterine fibroid embolization (UFE) (also known as UAE or Uterine Artery Embolization) shrinks uterine fibroids by depriving them of a blood supply using small particles called embolic agents. […] In UFE, the doctor uses fluoroscopy to inject the agents through a catheter and into the arteries that supply blood to the fibroids. The small particles block blood flow to the fibroids and cause them to shrink. Nearly 90 percent of patients with fibroids who undergo UFE experience relief from their symptoms.
- #26 What Are My Treatment Options for Uterine Fibroids? | Northwestern Medicinehttps://www.nm.org/healthbeat/healthy-tips/what-are-my-treatment-options-uterine-fibroids
UFE shrinks fibroids by blocking some of the blood supply to the uterus. UFE can decrease symptoms of pressure and bleeding. After the procedure, with the blood supply blocked, the fibroids shrink by about 30% to 50%. This procedure preserves your uterus. It is sometimes recommended by gynecologists for patients who want to get pregnant in the future. However, it is not approved by the Food and Drug Administration for women who want to get pregnant. […] A hysterectomy is a surgical procedure to remove the uterus. This is a permanent treatment because it removes the uterus and fibroids and prevents new fibroids from growing. Since your uterus is removed, you are not able to carry a pregnancy after a hysterectomy. […] Talk to your gynecologist about what procedures and treatments may be right for you and your fibroids.
- #27 Fibroid Treatment Options – Brigham and Women’s Hospitalhttps://www.brighamandwomens.org/obgyn/infertility-reproductive-surgery/cysts-and-fibroids/non-surgical-fibroid-treatment
UAE does not remove uterine fibroids, but causes them to shrink by 30 to 50 percent. […] Advantages of this procedure include no abdominal incisions and a shorter recovery time. After this procedure women may experience amenorrhea (lack of periods) depending on their age. Fibroids can recur or revascularize after this procedure, and up to 20 percent of women seek additional treatments in the five years following UAE. […] MRI-guided focused ultrasound (FUS) is a noninvasive treatment option for uterine fibroids that destroys fibroids while preserving the normal uterus. Focused high-frequency, high-energy sound waves are used to target the proteins in fibroids, until they are destroyed. Used in combination with MRI, FUS allows physicians to precisely target and monitor therapy. A single treatment session lasts approximately 3 hours. Although fibroids are treated and ultimately decrease in size, they are not removed. Women are able to resume normal activity within a day of the procedure, however the long-term effectiveness of this treatment is not known and it is not recommended for women who want to preserve their fertility.
- #28 Uterine fibroids – UF Healthhttps://ufhealth.org/conditions-and-treatments/uterine-fibroids
Medical therapies that can treat the fibroid symptoms of bleeding and pain include anti-inflammatories, tranexamic acid, levonorgestrel-intrauterine devices (IUDs) and oral contraceptives. […] Interventional procedures such as uterine artery embolization (UAE) and magnetic resonance-guided focused radio frequency ablation (MRgFUS) are not recommended in women desiring future pregnancies because there is a risk of loss of ovarian and uterine function. […] Surgical options include myomectomy (removal of fibroids only) or hysterectomy (removal of the uterus and fibroids) depending on the woman’s personal desires and age. […] Myomectomy preserves the uterus for future childbearing. […] Hysterectomy is removal of the uterus and fibroids. […] Laparoscopic radio frequency volumetric thermal ablation is a surgical laparoscopic technique under ultrasound guidance that ablates fibroids causing fibroid cellular death through small abdominal incisions.
- #29 Uterine fibroids and uterine fibroid embolization (UFE) treatment | Society of Interventional Radiologyhttps://www.sirweb.org/for-patients/conditions-and-treatments/uterine-fibroids/
Uterine fibroid embolization avoids surgery, preserves the uterus, controls symptoms and improves quality of life. […] UFE avoids surgery, preserves your uterus, controls symptoms and significantly improves quality of life. Approximately nine out of 10 women who undergo uterine fibroid embolization will experience significant improvement, or their symptoms will go away completely. […] For women with symptomatic fibroids, UFE converts these very disruptive, living fibroids into smaller, dead passenger fibroids that will never bother the woman ever again. […] UFE provides women relief from their symptoms with a shorter recovery period compared to surgery, such as hysterectomy or myomectomy. […] UFE is also less painful than surgeries, making it a more appealing option for many women.
- #30 Introduction – Management of Uterine Fibroids – NCBI Bookshelfhttps://www.ncbi.nlm.nih.gov/books/NBK537736/
This medical menopause decreases fibroid growth, promotes uterine involution, and reliably produces amenorrhea. […] Progesterone receptor agents modulate progesterone activity. […] Uterine artery embolization (UAE) involves placement of a catheter through a blood vessel in the groin, using techniques similar to cardiac catheterization. […] This procedure is an option for women who wish to avoid surgery, are poor candidates for surgery, or who wish to retain their uterus. […] High intensity focused ultrasound (HIFU), guided by ultrasound or MRI, directs a focused ultrasound beam to the fibroid. […] Endometrial ablation is a procedure that destroys (ablates) the uterine lining (endometrium) using one of these techniques: laser, radiofrequency, thermal balloon, electricity (cautery, roller-ball), freezing, or microwave.
- #31 Patient education: Uterine fibroids (Beyond the Basics) – UpToDatehttps://www.uptodate.com/contents/uterine-fibroids-beyond-the-basics/print
Myomectomy is a surgery done to remove fibroids, which can reduce both bleeding and size-related symptoms. […] Uterine artery embolization (UAE), also called uterine fibroid embolization (UFE), is a treatment that blocks the blood supply to fibroids. This causes the fibroid to shrink within weeks to several months after the treatment and decreases other fibroid symptoms including heavy menstrual bleeding. […] Magnetic resonance-guided focused ultrasound surgery (MRgFUS or FUS) is also a fibroid treatment option. This noninvasive treatment takes place in an MRI machine, which guides the treatment. […] Endometrial ablation destroys the lining of the uterus. The treatment does not shrink the fibroid(s) but can help to decrease heavy menstrual bleeding caused by fibroids. […] Hysterectomy is a surgery that removes the uterus. Hysterectomy is a permanent treatment that cures heavy menstrual bleeding and the bulk of related symptoms of fibroids.
- #32 No âbestâ treatment for common uterine fibroids – Harvard Healthhttps://www.health.harvard.edu/blog/no-best-treatment-for-common-uterine-fibroids-201504237918
Removal of the uterus (hysterectomy) is a popular option for women who are done having children. With the uterus gone, new fibroids cant form. But traditional hysterectomy, in which a surgeon makes a large incision in the abdomen, is major surgery. […] Women with heavy bleeding who do not want to have a hysterectomy can turn to both medical and surgical options. Some medications reduce heavy bleeding by helping blood clot. Hormonal birth control works by thinning the endometrium. This is the nutrient-rich lining of the uterus that is shed during a womans period. Medications can relieve symptoms, but they dont treat the underlying problem. […] A surgical option to treat heavy bleeding is hysteroscopic myomectomy. In this procedure, a thin tube called an endoscope is passed through the cervix and into the uterus. The fibroid is shaved and removed, but the uterus is left intact. If a woman does not want to have children, she can opt for endometrial ablation. In this procedure, the endometrium is destroyed, often with heat or cold.
- #33 Fibroid Treatment | Center for Women’s Health | OHSUhttps://www.ohsu.edu/womens-health/fibroid-treatment
This procedure destroys the lining of the uterus (endometrium), which can reduce heavy bleeding during your period. […] A radiologist injects tiny particles (about the size of a grain of sand) into your blood vessels. […] This procedure works best to treat submucosal and intramural fibroids. […] Our team has decades of experience in the surgical treatment of fibroids, including complex cases. […] Surgical options for fibroids include laparoscopic or abdominal myomectomy. […] This surgery removes just the fibroids, leaving the uterus and cervix in place, so you may be able to get pregnant later. […] You won’t be able to become pregnant after a hysterectomy, but there’s no chance of fibroids growing back.
- #34 Patient education: Uterine fibroids (Beyond the Basics) – UpToDatehttps://www.uptodate.com/contents/uterine-fibroids-beyond-the-basics
Uterine artery embolization (UAE), also called uterine fibroid embolization (UFE), is a treatment that blocks the blood supply to fibroids. This causes the fibroid to shrink within weeks to several months after the treatment and decreases other fibroid symptoms including heavy menstrual bleeding. […] Magnetic resonance-guided focused ultrasound surgery (MRgFUS or FUS) is also a fibroid treatment option. This noninvasive treatment takes place in an MRI machine, which guides the treatment. […] Ultrasound-guided radiofrequency ablationâThere are two ultrasound-guided radiofrequency ablation techniques available: one is laparoscopic (eg, Acessa) and one is transcervical (eg, Sonata). […] Endometrial ablation destroys the lining of the uterus. The treatment does not shrink the fibroid(s) but can help to decrease heavy menstrual bleeding caused by fibroids. […] Hysterectomy is a surgery that removes the uterus. The ovaries and cervix may be left in place when the hysterectomy is for uterine fibroids. Hysterectomy is a permanent treatment that cures heavy menstrual bleeding and the bulk of related symptoms of fibroids.
- #35 Advanced Fibroid Treatment | Stony Brook Medicine Women’s Health Serviceshttps://womenshealth.stonybrookmedicine.edu/advanced-fibroid-treatment
Types of minimally invasive procedures we perform include: […] Uses an intra-uterine ultrasound probe to target and then ablate fibroids. […] Blocks blood flow to fibroids, shrinking them over time (this can be performed by our Interventional Radiology colleagues). […] Inserts a tiny camera into the uterus to remove small fibroids within the endometrial cavity. […] Surgery is the most traditional treatment for removing fibroids. Options include: […] Removes fibroids surgically, while preserving your uterus. […] Removes fibroids and the entire uterus. […] Removes fibroids by making a few small cuts near your belly button and then inserting surgical tools through the incisions to reach and take out the growths. […] When seeking fibroid treatment, you want a combination of the most advanced procedure options, skilled surgeons and compassionate care. Thats exactly what youll find at Stony Brook Medicine.
- #36 Uterine Fibroids | Wide Range of Treatment Options :: Minnesota Women’s Care OBGYN and Urogynecologyhttps://mnwcare.com/our-services/gynecology/fibroids-treatments
Tranexamic acid („Lysteda”): This is a non-hormonal medication that works to slow down the breakdown of blood clots. In turn, slows down bleeding, and in this case can be used to reduce fibroid related bleeding. […] Essentially a myomectomy is a procedure where the fibroids are surgically removed from the uterus, and the uterine tissue is repaired. […] This procedure is generally recommended for pre-menopausal people who have symptomatic fibroids (bleeding or bulky) and wish to retain their uterus but do not intend for future pregnancy. […] Laparoscopic radiofrequency fibroid ablation (Lap-RFA, brand name Acessa) is a minimally invasive, energy-based treatment that reduces fibroid-related symptoms by reducing fibroid volume. […] After one year, the size of the fibroid decreases by up to 66%, resulting in a significant reduction in pelvic pain, heavy periods, and bulk. […] For this reason, should be used with caution if pregnancy is desired.
- #37 Shrink Them, Zap Them, Starve Them: Newer, Minimally Invasive Fibroid Treatments Offer Hysterectomy Alternative | NYU Langone Newshttps://nyulangone.org/news/shrink-them-zap-them-starve-them-newer-minimally-invasive-fibroid-treatments-offer-hysterectomy-alternative
Two U.S. Food and Drug Administration (FDA)approved fibroid medications: Oriahnn and Myfembree, have been shown to significantly reduce heavy menstrual bleeding associated with uterine fibroids. […] Uterine fibroid embolization is a minimally invasive outpatient procedure performed by an interventional radiologist. […] One of the most common fibroid procedures, myomectomy is a minimally invasive surgery that removes fibroids through the abdomen with tiny, thumb-size incisions. […] Transcervical fibroid ablation, often performed using the Sonata System, is one of the newest tools in fibroid treatment. […] In a study in the Journal of Gynecologic Surgery involving 147 women who had Sonata treatment, 94 percent were satisfied with the treatment and 88 percent reported reduced fibroid symptoms after three years. […] The Center for Fibroid Care is actively involved in research to improve fibroid management. […] Ultimately, we hope to better understand if LIFE can modify fibroid recurrence, says Dr. Shirazian.
- #38 Uterine fibroids and uterine fibroid embolization (UFE) treatment | Society of Interventional Radiologyhttps://www.sirweb.org/for-patients/conditions-and-treatments/uterine-fibroids/
Uterine fibroid embolization avoids surgery, preserves the uterus, controls symptoms and improves quality of life. […] UFE avoids surgery, preserves your uterus, controls symptoms and significantly improves quality of life. Approximately nine out of 10 women who undergo uterine fibroid embolization will experience significant improvement, or their symptoms will go away completely. […] For women with symptomatic fibroids, UFE converts these very disruptive, living fibroids into smaller, dead passenger fibroids that will never bother the woman ever again. […] UFE provides women relief from their symptoms with a shorter recovery period compared to surgery, such as hysterectomy or myomectomy. […] UFE is also less painful than surgeries, making it a more appealing option for many women.
- #39 Uterine Fibroid Treatment Information | Insightechttps://insightec.com/patients/uterine-fibroids-treatment/
Uterine Fibroids, also referred to as leiomyomas or myomas, are benign muscle tumors in various locations in the uterus that cause a range of symptoms. Insightecs MR-guided Focused ultrasound (MRgFUS) technology provides uterine-sparing, outpatient treatment option to help relieve symptomatic symptoms from uterine fibroids. […] During treatment, ultrasound beams are focused to a focal point heating and ablating targeted tissue. The treatment is guided by MRI, providing high resolution images of the target and adjacent structures, as well as continuous temperature monitoring. If necessary, parameters can be adjusted to ensure optimal response. […] This treatment is incisionless, there is no scarring with minimal side effects, often allowing patients to return to normal activity within days.
- #40 Fibroid Treatment Options – Brigham and Women’s Hospitalhttps://www.brighamandwomens.org/obgyn/infertility-reproductive-surgery/cysts-and-fibroids/non-surgical-fibroid-treatment
UAE does not remove uterine fibroids, but causes them to shrink by 30 to 50 percent. […] Advantages of this procedure include no abdominal incisions and a shorter recovery time. After this procedure women may experience amenorrhea (lack of periods) depending on their age. Fibroids can recur or revascularize after this procedure, and up to 20 percent of women seek additional treatments in the five years following UAE. […] MRI-guided focused ultrasound (FUS) is a noninvasive treatment option for uterine fibroids that destroys fibroids while preserving the normal uterus. Focused high-frequency, high-energy sound waves are used to target the proteins in fibroids, until they are destroyed. Used in combination with MRI, FUS allows physicians to precisely target and monitor therapy. A single treatment session lasts approximately 3 hours. Although fibroids are treated and ultimately decrease in size, they are not removed. Women are able to resume normal activity within a day of the procedure, however the long-term effectiveness of this treatment is not known and it is not recommended for women who want to preserve their fertility.
- #41 Fibroid Center Treatments | Stanford Health Carehttps://stanfordhealthcare.org/medical-clinics/fibroid-center/treatments.html
Fibroids are common, benign tumors present in 70% of women, often presenting with symptoms such as difficult urination, excessive bleeding and pain. There are several types of treatment options for fibroids, from non-invasive MRI-Guided Focused Ultrasound (MRgFUS), minimally invasive options such as Uterine Fibroid Embolization (UFE) and surgical options. […] We will determine the most effective plan for you based on your condition, expectations and preferences. We offer fertility-sparing treatment options if you wish to start or add to your family. […] Treatment options include: […] During this procedure, we cut off the blood supply to the uterine fibroids. This causes them to shrink. […] This is a specialized, noninvasive method to treat fibroids. We use an MRI-guided focused ultrasound surgery (MRgFUS) to target and destroy fibroids.
- #42 What Are My Treatment Options for Uterine Fibroids? | Northwestern Medicinehttps://www.nm.org/healthbeat/healthy-tips/what-are-my-treatment-options-uterine-fibroids
Uterine fibroids are fibrous, solid, noncancerous tumors of the uterus. They are also known as uterine leiomyomas or myomas. They’re common and may not require treatment. „If you are diagnosed with uterine fibroids and have no symptoms, there might be no need for treatment,” says Dr. Chaudhari. „Your physician may simply monitor their growth at your annual exams or more frequently if needed.” Your physician may recommend treatment if you: […] Myomectomy is a surgical procedure to remove fibroids while keeping the uterus in place. Myomectomy may reduce both bleeding and pressure symptoms. The goal of myomectomy is to keep the uterus for future fertility. […] New fibroids can grow back after surgery. Between 10% and 25% of patients who undergo myomectomy will need a second fibroid surgery during their reproductive years, and the timing of repeat surgeries varies. Myomectomy is considered the gold standard for patients who want to get pregnant in the future, but may not be right for everyone.
- #43 Fibroid Treatment | Center for Women’s Health | OHSUhttps://www.ohsu.edu/womens-health/fibroid-treatment
This procedure destroys the lining of the uterus (endometrium), which can reduce heavy bleeding during your period. […] A radiologist injects tiny particles (about the size of a grain of sand) into your blood vessels. […] This procedure works best to treat submucosal and intramural fibroids. […] Our team has decades of experience in the surgical treatment of fibroids, including complex cases. […] Surgical options for fibroids include laparoscopic or abdominal myomectomy. […] This surgery removes just the fibroids, leaving the uterus and cervix in place, so you may be able to get pregnant later. […] You won’t be able to become pregnant after a hysterectomy, but there’s no chance of fibroids growing back.
- #44 Get Uterine Fibroid Treatment | Cleveland Clinichttps://my.clevelandclinic.org/services/uterine-fibroids-treatment
Your surgeon uses heat to destroy the lining of the uterus. This treatment may burn small fibroids near the uterine lining, but its primarily done to reduce heavy bleeding during periods. Endometrial ablation affects fertility, so we would not recommend this procedure if youre planning on having children. […] […] We may recommend a myomectomy if you plan on having children. During this procedure, we remove the uterine fibroids and keep your uterus intact. Our surgeons can perform most myomectomies hysteroscopically or laparoscopically. […] […] We can remove small fibroids in the uterine cavity using a hysteroscope. This is a thin, lighted tube used to look inside the vagina, cervix and uterus. We attach surgical tools to the hysteroscope to take the fibroids out through the vagina. Without the need for any incisions, this is a quick, outpatient procedure. Most women can return to normal activities within a few days. […]
- #45 Uterine Fibroids: Diagnosis and Treatment | AAFPhttps://www.aafp.org/pubs/afp/issues/2017/0115/p100.html
Hysteroscopic myomectomy is the preferred surgical procedure for women with submucosal fibroids who wish to preserve their uterus or fertility. […] Uterine artery embolization is an option for women who wish to preserve their uterus or avoid surgery because of medical comorbidities or personal preference. […] Myolysis is a minimally invasive procedure targeting the destruction of fibroids via a focused energy delivery system such as heat, laser, or more recently, magnetic resonance-guided focused ultrasound surgery.
- #46 Get Uterine Fibroid Treatment | Cleveland Clinichttps://my.clevelandclinic.org/services/uterine-fibroids-treatment
We use this procedure to remove larger uterine fibroids while preserving the uterus. However, it requires small incisions in the abdomen, often measuring 5-10mm. In some cases, a surgeon may use the assistance of a robot depending on the surgeons preference. […] […] By the age of 60, one in three women will have had a hysterectomy (a surgery to remove the uterus). The majority of hysterectomies are done to treat fibroids. […] […] This minimally invasive procedure applies heat directly into the fibroids. This causes the fibroids to shrink over time and reduces symptoms. RFA may be done vaginally or laparoscopically depending on the size, number and location of the fibroids. […] […] Whether its miserable periods or pain, fibroids can pull you away from your active life. The good news? You can work with our team of experts to create a treatment plan thatll work for you. With treatment, comes relief from symptoms that get in the way of the life you want to live.
- #47 Uterine Fibroids: Diagnosis & Treatment | NewYork-Presbyterianhttps://www.nyp.org/womens/fibroids/treatment
Myomectomy: Surgery to remove fibroids without removing the healthy tissue of the uterus, which may be performed using minimally invasive surgery depending upon the location of the fibroids. These procedures may include robotic or laparoscopic myomectomy (through several tiny incisions in the abdomen) or hysteroscopic myomectomy (through the vagina and cervix). […] Hysterectomy: Surgery to remove the entire uterus is the only sure way to cure fibroids, which may be performed by a minimally invasive approach even for larger fibroids. […] Our team of fibroid specialists is committed to giving patients with uterine fibroids comprehensive, ongoing care to live the best quality of life. Your long-term care may include periodic evaluations to review your symptoms and monitor the fibroid with abdominal and pelvic examinations depending on your individual needs. Fibroids are likely to grow until a patient reaches menopause, and treatments can be offered throughout their lifetime.
- #48 Choosing A Uterine Fibroid Treatment | Talking Fibroidshttps://talkingfibroids.com/aboutwomen-talking-fibroids/choosing-the-right-uterine-fibroid-treatment/
Laparoscopic myomectomy can be performed if your fibroids are outside the uterine cavity, but are small and few in number. […] Abdominal myomectomy requires an average hospital stay of 1 to 4 days and a full recovery time of 4 to 6 weeks. […] There are many options out there for women who are dealing with uterine fibroids.
- #49 What Are My Treatment Options for Uterine Fibroids? | Northwestern Medicinehttps://www.nm.org/healthbeat/healthy-tips/what-are-my-treatment-options-uterine-fibroids
Uterine fibroids are fibrous, solid, noncancerous tumors of the uterus. They are also known as uterine leiomyomas or myomas. They’re common and may not require treatment. „If you are diagnosed with uterine fibroids and have no symptoms, there might be no need for treatment,” says Dr. Chaudhari. „Your physician may simply monitor their growth at your annual exams or more frequently if needed.” Your physician may recommend treatment if you: […] Myomectomy is a surgical procedure to remove fibroids while keeping the uterus in place. Myomectomy may reduce both bleeding and pressure symptoms. The goal of myomectomy is to keep the uterus for future fertility. […] New fibroids can grow back after surgery. Between 10% and 25% of patients who undergo myomectomy will need a second fibroid surgery during their reproductive years, and the timing of repeat surgeries varies. Myomectomy is considered the gold standard for patients who want to get pregnant in the future, but may not be right for everyone.
- #50 Choosing A Uterine Fibroid Treatment | Talking Fibroidshttps://talkingfibroids.com/aboutwomen-talking-fibroids/choosing-the-right-uterine-fibroid-treatment/
Laparoscopic myomectomy can be performed if your fibroids are outside the uterine cavity, but are small and few in number. […] Abdominal myomectomy requires an average hospital stay of 1 to 4 days and a full recovery time of 4 to 6 weeks. […] There are many options out there for women who are dealing with uterine fibroids.
- #51 Uterine Fibroids: Causes, Symptoms, and Treatmenthttps://www.webmd.com/women/uterine-fibroids/uterine-fibroids
Endometrial ablation. A surgeon uses either a laser, wire loops, boiling water, an electric current, microwaves, or freezing to remove or destroy the lining of your uterus. […] Uterine fibroid embolization (UFE), or uterine artery embolization (UAE). In this procedure, a doctor blocks the flow of blood to your fibroids by inserting gel or plastic particles into the nearby blood vessels. This makes the fibroids shrink. […] Hysterectomy. This surgery removes your uterus completely. This is the only way to cure fibroids entirely. It’s a major surgery, but your doctor has options for how to do it, including cutting through your belly or even laparoscopy. […] Treatment options range from watchful waiting for mild symptoms to medications and surgery for more severe cases.
- #52 Uterine fibroids – Diagnosis and treatment – Mayo Clinichttps://www.mayoclinic.org/diseases-conditions/uterine-fibroids/diagnosis-treatment/drc-20354294
Small particles called embolic agents are injected into the uterine artery through a small catheter. The embolic agents then flow to the fibroids and lodge in the arteries that feed them. This cuts off blood flow to starve the tumors. […] During laparoscopic radiofrequency ablation, the doctor sees inside the abdomen using two special instruments. […] With any procedure that doesn’t remove the uterus, there’s a risk that new fibroids could grow and cause symptoms. […] Hysterectomy remains the only proven permanent solution for uterine fibroids. […] If fibroid treatment is needed and you want to preserve your fertility myomectomy is often the treatment of choice. But all treatments have risks and benefits. Talk about these with your doctor. […] For all procedures except hysterectomy, seedlings tiny tumors that your doctor doesn’t detect during surgery could one day grow and cause symptoms that need treatment.
- #53 Uterine Fibroids: Diagnosis & Treatment | NewYork-Presbyterianhttps://www.nyp.org/womens/fibroids/treatment
Myomectomy: Surgery to remove fibroids without removing the healthy tissue of the uterus, which may be performed using minimally invasive surgery depending upon the location of the fibroids. These procedures may include robotic or laparoscopic myomectomy (through several tiny incisions in the abdomen) or hysteroscopic myomectomy (through the vagina and cervix). […] Hysterectomy: Surgery to remove the entire uterus is the only sure way to cure fibroids, which may be performed by a minimally invasive approach even for larger fibroids. […] Our team of fibroid specialists is committed to giving patients with uterine fibroids comprehensive, ongoing care to live the best quality of life. Your long-term care may include periodic evaluations to review your symptoms and monitor the fibroid with abdominal and pelvic examinations depending on your individual needs. Fibroids are likely to grow until a patient reaches menopause, and treatments can be offered throughout their lifetime.
- #54 Uterine Fibroids | ACOGhttps://www.acog.org/womens-health/faqs/uterine-fibroids
Hysterectomy is the removal of the uterus. The ovaries may or may not be removed. Hysterectomy is done when other treatments have not worked or are not possible or the fibroids are very large. You are no longer able to have children after having a hysterectomy. […] Other treatment options include the following: […] Uterine artery embolization (UAE) In this procedure, tiny particles (about the size of grains of sand) are injected into the blood vessels that lead to the uterus. The particles cut off the blood flow to the fibroid and cause it to shrink. […] Radiofrequency ablation (RFA) This procedure uses energy and heat to shrink the size of fibroids. […] MRI-guided ultrasound surgery In this new approach, ultrasound waves are used to destroy fibroids. The waves are directed at the fibroids through the skin with the help of magnetic resonance imaging.
- #55 Uterine Fibroid Treatmenthttps://www.froedtert.com/womens-health/uterine-fibroid-treatment
MRgFUS uses ultrasonic pulses, or sonications, to heat up and destroy fibroid tumors. […] This procedure consists of the surgical removal of uterine fibroids. […] Pregnancy is possible after a myomectomy from either approach. […] A hysterectomy is the removal of the uterus (including all of the fibroids in it), and often the cervix. […] Most often, we don’t remove the ovaries, allowing you to retain your natural hormones for health benefits.
- #56https://www.advocatehealth.com/health-services/urogynecology/services-treatments/uterine-fibroids-treatment
Minimally invasive robotic uterine fibroid surgery to remove fibroids using the da Vinci Robotic Surgical System, which allows our experts to perform procedures through very small incisions with unmatched precision. […] Minimally invasive procedure performed by our skilled interventional radiologists. It involves guiding a catheter through a very small incision into the uterine arteries that supply blood to the fibroids. Small particles are released into the arteries to block the blood flow to the fibroids, causing them to shrink and die. […] Removing fibroids through minimally invasive methods avoids removal of the uterus and preserves fertility for women of child-bearing age. These procedures take less time than conventional surgeries and result in smaller scars, faster recovery time and fewer infections. They also reduce or eliminate the symptoms of fibroids such as pain and bleeding.
- #57 The Conservative and Interventional Treatment of Fibroidshttps://pmc.ncbi.nlm.nih.gov/articles/PMC4298239/
In women with symptomatic fibroids, drug therapy, surgical therapy now as minimally invasive operations whether organ-preserving or in the form of hysterectomy, and other interventional techniques such as uterine artery embolization (UAE) and fibroid treatment using highly focused ultrasound (FUS) can be offered. […] The evidence base relating to these various therapies is heterogeneous. In particular, there is not enough evidence from randomized controlled trials (RCTs) to form a judgment about whether fertility is improved after enucleation of fibroids. By contrast, alleviation of symptoms and improvement in quality of life after medical and surgical treatment and UAE are very well supported by evidence from randomized studies and meta-analyses. […] The primary indication for drug therapy is pretreatment before surgery. There are no studies showing improved pregnancy or birth rates.
- #58 Introduction – Management of Uterine Fibroids – NCBI Bookshelfhttps://www.ncbi.nlm.nih.gov/books/NBK537736/
Treatment options differ in fundamental aspects such as cost, invasiveness, recovery time, risks, likelihood of long-term resolution of symptoms, need for future care for fibroids, and influence on future childbearing. […] This report is organized from least invasive to more invasive treatment options: expectant management, then medical treatment, and then outpatient procedures and major surgeries. […] In any given year, a greater proportion of women with symptomatic fibroids receive medical therapy than surgery. […] Though no medications have been specifically cleared by the U.S. Food and Drug Administration (FDA) for fibroid treatment, several medications are used off-label for fibroid symptoms. […] GnRH agonists down-regulate ovarian production of estrogen and progesterone and decrease stimulation of hormone receptors.
- #59 Fibroid Specialist NYC | Viva Evehttps://vivaeve.com/services/fibroid-specialist/
Because theyre noncancerous, fibroids are usually not life-threatening. However, for women who suffer from fibroids, the symptoms may dramatically compromise their quality of life. […] Traditionally, doctors usually recommended that fibroids be treated by hysterectomy (removal of the uterus) or myomectomy (removal of the fibroids)both major, invasive surgeries requiring hospitalization with long recovery times and other disadvantages, such as higher complication rates and potential organ loss. […] For over two decades now, minimally invasive UFE has been used to successfully treat fibroids and help women get back to their lives much more quickly. […] Fibroids may affect a womans ability to conceive for a number of reasons. Fibroids can create a physical barrier to pregnancy if theyre positioned in the uterus where the baby needs to be.
- #60 Treatment of uterine fibroids patient education fact sheet | ReproductiveFacts.orghttps://www.reproductivefacts.org/news-and-publications/fact-sheets-and-infographics/treatment-of-uterine-fibroids/
Not usually, because most patients with fibroids do not have symptoms. […] Surgery is considered when fibroids cause significant symptoms. […] Some fibroids are affected by levels of the hormone estrogen and can be managed with medicine. […] For individuals who wish to get pregnant, surgical removal of the fibroids through a surgery called a myomectomy is often the best option. […] There are different types of myomectomies that can be done. […] Although recovery time varies with the type of surgery and typically is short, the uterus needs time to heal, and it may be 1-6 months before you are given the green light to attempt pregnancy. […] This risk of new fibroids growing back after surgery is about 30% over 10 years. […] Another laparoscopic technique called myolysis involves burning the fibroids through heat and cold energy via needles or lasers. […] Uterine artery embolization is performed by a radiologist. […] About half of all hysterectomies (surgical removal of the uterus) are done to treat uterine fibroids. […] Hysterectomy is most appropriate for those with symptoms who do not wish to get pregnant later.
- #61 Treatment of uterine fibroids patient education fact sheet | ReproductiveFacts.orghttps://www.reproductivefacts.org/news-and-publications/fact-sheets-and-infographics/treatment-of-uterine-fibroids/
Not usually, because most patients with fibroids do not have symptoms. […] Surgery is considered when fibroids cause significant symptoms. […] Some fibroids are affected by levels of the hormone estrogen and can be managed with medicine. […] For individuals who wish to get pregnant, surgical removal of the fibroids through a surgery called a myomectomy is often the best option. […] There are different types of myomectomies that can be done. […] Although recovery time varies with the type of surgery and typically is short, the uterus needs time to heal, and it may be 1-6 months before you are given the green light to attempt pregnancy. […] This risk of new fibroids growing back after surgery is about 30% over 10 years. […] Another laparoscopic technique called myolysis involves burning the fibroids through heat and cold energy via needles or lasers. […] Uterine artery embolization is performed by a radiologist. […] About half of all hysterectomies (surgical removal of the uterus) are done to treat uterine fibroids. […] Hysterectomy is most appropriate for those with symptoms who do not wish to get pregnant later.
- #62 Fibroid Treatments â Fibroid Treatment Collaborativehttps://www.fibroid.com/treatments/
Currently, the medical treatments available for fibroids can make symptoms better temporarily but they do not make the fibroids go away. […] On the horizon are several promising, new drugs that will treat the fibroids themselves not just the symptoms. […] Myomectomy is an operation in which fibroids are removed from within the uterus. […] For women with symptomatic fibroids who desire future childbearing, myomectomy is the best treatment option. […] Hysterectomy is a major surgical procedure in which the uterus (womb) is removed. Many women choose hysterectomy to definitively resolve their fibroid symptoms. […] The type of hysterectomy will depend on the size of the uterus and several other factors. […] Uterine artery embolization is a relatively new treatment alternative to open surgery for symptomatic fibroids. […] By stopping the blood flow, the fibroid begins to die and shrink in size. This will often decrease menstrual bleeding and symptoms of pain, pressure, urinary frequency or constipation.
- #63 Uterine Fibroid Treatments, UFE, MRgFUShttps://www.radiologyinfo.org/en/info/uterine-fibroid-treatment
Doctors use UFE and MRgFUS to treat symptomatic fibroids in the uterus. These procedures are non-surgical alternatives to hysterectomy and myomectomy. […] MRgFUS helps preserve the uterus and the patient’s ability to become pregnant. […] UFE is a more permanent solution than hormonal therapy. […] Follow-up studies have shown that nearly 90 percent of patients who have their fibroids treated by UFE experience either significant or complete resolution of their fibroid-related symptoms. […] The procedure may provide rapid improvement of symptoms associated with uterine fibroids without invasive surgery. […] MRgFUS preserves the uterus. A number of patients have had successful pregnancies after MRgFUS treatment for uterine fibroids. […] UFE should not be performed in patients who have no symptoms from their fibroid tumors, when cancer is a possibility, or when there is inflammation or infection in the pelvis. […] MRgFUS may not be a good choice for some patients, including pregnant patients, patients with multiple abdominal scars, patients with many fibroids or very large fibroids.
- #64 What Are My Treatment Options for Uterine Fibroids? | Northwestern Medicinehttps://www.nm.org/healthbeat/healthy-tips/what-are-my-treatment-options-uterine-fibroids
UFE shrinks fibroids by blocking some of the blood supply to the uterus. UFE can decrease symptoms of pressure and bleeding. After the procedure, with the blood supply blocked, the fibroids shrink by about 30% to 50%. This procedure preserves your uterus. It is sometimes recommended by gynecologists for patients who want to get pregnant in the future. However, it is not approved by the Food and Drug Administration for women who want to get pregnant. […] A hysterectomy is a surgical procedure to remove the uterus. This is a permanent treatment because it removes the uterus and fibroids and prevents new fibroids from growing. Since your uterus is removed, you are not able to carry a pregnancy after a hysterectomy. […] Talk to your gynecologist about what procedures and treatments may be right for you and your fibroids.
- #65 The Conservative and Interventional Treatment of Fibroidshttps://pmc.ncbi.nlm.nih.gov/articles/PMC4298239/
Since February 2012, the SPRM ulipristal acetate has been licensed for pretreatment before scheduled surgery. The main advantage of ulipristal acetate over GnRH analogs (leuprorelin acetate) is the lower incidence of unwanted effects. […] UAE as a uterine-preserving form of treatment for symptomatic uterine fibroids has been available to women since 1989. Embolization of the uterine artery is a possible alternative to hysterectomy, especially in women with multiple fibroids, very large fibroids, restricted operability, or a history of multiple operative procedures in the abdomen. […] Fibroid embolization is a treatment procedure supported by evidence from randomized studies. […] Patients with symptomatic uterine fibroids can be offered a number of different treatment options. The choice of therapeutic technique depends first and foremost on whether the patient still wishes to bear children. For those who do, or who wish to retain their uterus, the methods of choice are hysteroscopic myomectomy for intracavitary and submucosal fibroids and laparoscopic enucleation for intramural or transmural fibroids although it must be mentioned that the evidence that fibroid enucleation carries any advantage for women who wish to preserve their fertility is thin. […] For women who do not wish to preserve their fertility, the minimally invasive hysterectomy techniques and uterine artery embolization are the treatments of choice.
- #66 Fibroid Treatments â Fibroid Treatment Collaborativehttps://www.fibroid.com/treatments/
Currently, the medical treatments available for fibroids can make symptoms better temporarily but they do not make the fibroids go away. […] On the horizon are several promising, new drugs that will treat the fibroids themselves not just the symptoms. […] Myomectomy is an operation in which fibroids are removed from within the uterus. […] For women with symptomatic fibroids who desire future childbearing, myomectomy is the best treatment option. […] Hysterectomy is a major surgical procedure in which the uterus (womb) is removed. Many women choose hysterectomy to definitively resolve their fibroid symptoms. […] The type of hysterectomy will depend on the size of the uterus and several other factors. […] Uterine artery embolization is a relatively new treatment alternative to open surgery for symptomatic fibroids. […] By stopping the blood flow, the fibroid begins to die and shrink in size. This will often decrease menstrual bleeding and symptoms of pain, pressure, urinary frequency or constipation.
- #67 Engineering Smart Therapeutics: Innovative Uterine Fibroid Treatment | Duke Department of Obstetrics and Gynecologyhttps://obgyn.duke.edu/blog/engineering-smart-therapeutics-innovative-uterine-fibroid-treatment
A collaboration by researchers at Duke and North Carolina Central University (NCCU) aims to offer a more convenient, less invasive treatment for uterine fibroids, one of the most common and under-studied issues in women’s health. […] Current interventions are either expensive, difficult to access or have significant systemic side effects. […] Dr. Jayes has long been fascinated with this problem and is involved in developing a new therapeutic treatment using a drug capable of breaking fibroids down inside the body. […] The Liquogel + collagenase combination is effective. Over time collagenase degrades and softens the fibroid tissue. […] The combination of LiquoGel and the collagenase drug, by contrast, could be administered in a doctor’s office and would act only on the tumor itself. […] The team has secured follow-on funding from North Carolina Biotechnology Center to conduct scale-up production of LiquoGel and time-course studies, as well as other essential research to facilitate the process of enabling clinical trials and ultimately seeking FDA authorization.
- #68 Engineering Smart Therapeutics: Innovative Uterine Fibroid Treatment | Duke Department of Obstetrics and Gynecologyhttps://obgyn.duke.edu/blog/engineering-smart-therapeutics-innovative-uterine-fibroid-treatment
A collaboration by researchers at Duke and North Carolina Central University (NCCU) aims to offer a more convenient, less invasive treatment for uterine fibroids, one of the most common and under-studied issues in women’s health. […] Current interventions are either expensive, difficult to access or have significant systemic side effects. […] Dr. Jayes has long been fascinated with this problem and is involved in developing a new therapeutic treatment using a drug capable of breaking fibroids down inside the body. […] The Liquogel + collagenase combination is effective. Over time collagenase degrades and softens the fibroid tissue. […] The combination of LiquoGel and the collagenase drug, by contrast, could be administered in a doctor’s office and would act only on the tumor itself. […] The team has secured follow-on funding from North Carolina Biotechnology Center to conduct scale-up production of LiquoGel and time-course studies, as well as other essential research to facilitate the process of enabling clinical trials and ultimately seeking FDA authorization.
- #69 Shrink Them, Zap Them, Starve Them: Newer, Minimally Invasive Fibroid Treatments Offer Hysterectomy Alternative | NYU Langone Newshttps://nyulangone.org/news/shrink-them-zap-them-starve-them-newer-minimally-invasive-fibroid-treatments-offer-hysterectomy-alternative
Two U.S. Food and Drug Administration (FDA)approved fibroid medications: Oriahnn and Myfembree, have been shown to significantly reduce heavy menstrual bleeding associated with uterine fibroids. […] Uterine fibroid embolization is a minimally invasive outpatient procedure performed by an interventional radiologist. […] One of the most common fibroid procedures, myomectomy is a minimally invasive surgery that removes fibroids through the abdomen with tiny, thumb-size incisions. […] Transcervical fibroid ablation, often performed using the Sonata System, is one of the newest tools in fibroid treatment. […] In a study in the Journal of Gynecologic Surgery involving 147 women who had Sonata treatment, 94 percent were satisfied with the treatment and 88 percent reported reduced fibroid symptoms after three years. […] The Center for Fibroid Care is actively involved in research to improve fibroid management. […] Ultimately, we hope to better understand if LIFE can modify fibroid recurrence, says Dr. Shirazian.
- #70 Shrink Them, Zap Them, Starve Them: Newer, Minimally Invasive Fibroid Treatments Offer Hysterectomy Alternative | NYU Langone Newshttps://nyulangone.org/news/shrink-them-zap-them-starve-them-newer-minimally-invasive-fibroid-treatments-offer-hysterectomy-alternative
Two U.S. Food and Drug Administration (FDA)approved fibroid medications: Oriahnn and Myfembree, have been shown to significantly reduce heavy menstrual bleeding associated with uterine fibroids. […] Uterine fibroid embolization is a minimally invasive outpatient procedure performed by an interventional radiologist. […] One of the most common fibroid procedures, myomectomy is a minimally invasive surgery that removes fibroids through the abdomen with tiny, thumb-size incisions. […] Transcervical fibroid ablation, often performed using the Sonata System, is one of the newest tools in fibroid treatment. […] In a study in the Journal of Gynecologic Surgery involving 147 women who had Sonata treatment, 94 percent were satisfied with the treatment and 88 percent reported reduced fibroid symptoms after three years. […] The Center for Fibroid Care is actively involved in research to improve fibroid management. […] Ultimately, we hope to better understand if LIFE can modify fibroid recurrence, says Dr. Shirazian.
- #71 Uterine Fibroids: Diagnosis and Treatment | AAFPhttps://www.aafp.org/pubs/afp/issues/2017/0115/p100.html
Treatment of uterine fibroids should be tailored to the size and location of the tumors; the patient’s age, symptoms, desire to maintain fertility, and access to treatment; and the physician’s experience. […] Expectant management is appropriate for women with asymptomatic uterine fibroids. […] Medical therapy includes hormonal contraceptives, tranexamic acid, and nonsteroidal anti-inflammatory drugs. […] Gonadotropin-releasing hormone agonists and selective progesterone receptor modulators are options for patients who need temporary relief from symptoms preoperatively or who are approaching menopause. […] Hysterectomy provides a definitive cure for women with symptomatic fibroids who do not wish to preserve fertility, resulting in complete resolution of symptoms and improved quality of life.
- #72 The Conservative and Interventional Treatment of Fibroidshttps://pmc.ncbi.nlm.nih.gov/articles/PMC4298239/
Since February 2012, the SPRM ulipristal acetate has been licensed for pretreatment before scheduled surgery. The main advantage of ulipristal acetate over GnRH analogs (leuprorelin acetate) is the lower incidence of unwanted effects. […] UAE as a uterine-preserving form of treatment for symptomatic uterine fibroids has been available to women since 1989. Embolization of the uterine artery is a possible alternative to hysterectomy, especially in women with multiple fibroids, very large fibroids, restricted operability, or a history of multiple operative procedures in the abdomen. […] Fibroid embolization is a treatment procedure supported by evidence from randomized studies. […] Patients with symptomatic uterine fibroids can be offered a number of different treatment options. The choice of therapeutic technique depends first and foremost on whether the patient still wishes to bear children. For those who do, or who wish to retain their uterus, the methods of choice are hysteroscopic myomectomy for intracavitary and submucosal fibroids and laparoscopic enucleation for intramural or transmural fibroids although it must be mentioned that the evidence that fibroid enucleation carries any advantage for women who wish to preserve their fertility is thin. […] For women who do not wish to preserve their fertility, the minimally invasive hysterectomy techniques and uterine artery embolization are the treatments of choice.
- #73 No âbestâ treatment for common uterine fibroids – Harvard Healthhttps://www.health.harvard.edu/blog/no-best-treatment-for-common-uterine-fibroids-201504237918
Fibroids are noncancerous tumors that grow in the uterus. They may be smaller than a seed or bigger than a grapefruit. A woman may have only one fibroid or she may have many. Depending on their size, number, and location, fibroids can cause heavy bleeding and long menstrual periods (which can, in turn, cause anemia), pelvic pain, frequent urination, or constipation. Fibroids can also cause infertility and repeated miscarriages. […] Given how common uterine fibroids are, youd think there would be a lot of research comparing treatment options. In fact, there are only a few randomized trials to guide treatment. […] First, are the fibroids causing symptoms? If not which is often the case no treatment is needed. […] I consider the severity of symptoms and the impact of those symptoms on a womans quality of life to be the foundation of treatment decision making, says Dr. Aaron Styer, an obstetrician-gynecologist at Harvard-affiliated Massachusetts General Hospital. For example, is the woman missing work, requiring frequent hospitalizations, or missing out on normal, daily life? If so, that information will guide the treatment I recommend.
- #74 Uterine Fibroids: Diagnosis and Treatment | AAFPhttps://www.aafp.org/pubs/afp/issues/2017/0115/p100.html
Treatment of uterine fibroids should be tailored to the size and location of the tumors; the patient’s age, symptoms, desire to maintain fertility, and access to treatment; and the physician’s experience. […] Expectant management is appropriate for women with asymptomatic uterine fibroids. […] Medical therapy includes hormonal contraceptives, tranexamic acid, and nonsteroidal anti-inflammatory drugs. […] Gonadotropin-releasing hormone agonists and selective progesterone receptor modulators are options for patients who need temporary relief from symptoms preoperatively or who are approaching menopause. […] Hysterectomy provides a definitive cure for women with symptomatic fibroids who do not wish to preserve fertility, resulting in complete resolution of symptoms and improved quality of life.
- #75 Patient education: Uterine fibroids (Beyond the Basics) – UpToDatehttps://www.uptodate.com/contents/uterine-fibroids-beyond-the-basics/print
Fibroids are growths of the uterus. Treatments are available for fibroid-related problems like heavy menstrual bleeding, pain or pressure in the pelvis, or problems with pregnancy or infertility. […] If your fibroids are not causing bothersome symptoms, you can choose not to have treatment. If you do have symptoms, your options include observation, medication, or surgical treatment. The best treatment depends on which symptom(s) is most bothersome to you. […] Most medications aim to reduce the heavy menstrual bleeding that is common in people with fibroids. A few also shrink the fibroid, and some are focused on reducing pain or correcting anemia. Medications are often recommended before surgical treatments. […] Your doctor might recommend a surgical or interventional treatment for fibroids if: You have fibroid-related heavy menstrual bleeding, pain, or pressure that does not get better with medication; You are trying to get pregnant and fibroids appear to be interfering; The size of the fibroid is causing symptoms.
- #76 Managing Fibroids: Medical and Surgical Options – The ObG Projecthttps://www.obgproject.com/2021/06/27/managing-fibroids-medical-and-surgical-options/
Uterine artery embolization (UAE) can be used for treatment of leiomyomas in patients who desire uterine preservation. […] Laparoscopic radiofrequency ablation can be used as a minimally invasive treatment option for symptomatic leiomyomas for patients who desire uterine preservation. […] Myomectomy allows fibroid removal in patients desiring their uterus. […] Hysterectomy is the definitive surgical management option for treatment of leiomyoma in patients who do not desire future childbearing or uterine preservation. […] If a patient desires uterine preservation or future pregnancy, myomectomy is recommended.
- #77https://myhealth.alberta.ca/Health/pages/conditions.aspx?hwid=tv7259
For people who are close to menopause (when fibroids will shrink on their own), short-term relief from GnRH-a therapy can be a good choice. […] You have severe bleeding from uterine fibroids and need treatment right away. […] Other treatments for fibroids haven’t helped your symptoms, and you’re planning surgery later. […] You’re close to menopause, when fibroids will get smaller or go away. […] You’re planning to have surgery to take out large fibroids. […] You’re not planning on getting pregnant soon. […] GnRH-a can shrink fibroids before surgery to remove them. This makes fibroids easier to remove and can reduce the risk of bleeding during surgery and problems after surgery. […] GnRH-a can cause bone loss, so it is used for a limited amount of time. […] The medicine only treats fibroids for a while. Fibroids tend to grow back after you stop taking GnRH-a.
- #78 Uterine Fibroids: Diagnosis and Treatment | AAFPhttps://www.aafp.org/pubs/afp/issues/2017/0115/p100.html
Treatment of uterine fibroids should be tailored to the size and location of the tumors; the patient’s age, symptoms, desire to maintain fertility, and access to treatment; and the physician’s experience. […] Expectant management is appropriate for women with asymptomatic uterine fibroids. […] Medical therapy includes hormonal contraceptives, tranexamic acid, and nonsteroidal anti-inflammatory drugs. […] Gonadotropin-releasing hormone agonists and selective progesterone receptor modulators are options for patients who need temporary relief from symptoms preoperatively or who are approaching menopause. […] Hysterectomy provides a definitive cure for women with symptomatic fibroids who do not wish to preserve fertility, resulting in complete resolution of symptoms and improved quality of life.
- #79 Uterine Fibroids: Diagnosis and Treatment | AAFPhttps://www.aafp.org/pubs/afp/issues/2017/0115/p100.html
Hysteroscopic myomectomy is the preferred surgical procedure for women with submucosal fibroids who wish to preserve their uterus or fertility. […] Uterine artery embolization is an option for women who wish to preserve their uterus or avoid surgery because of medical comorbidities or personal preference. […] Myolysis is a minimally invasive procedure targeting the destruction of fibroids via a focused energy delivery system such as heat, laser, or more recently, magnetic resonance-guided focused ultrasound surgery.
- #80 Uterine Fibroids: What Treatments Are Available > News > Yale Medicinehttps://www.yalemedicine.org/news/uterine-fibroids-treatments
Women can also choose to have uterine artery embolization, which is noninvasive and offers a faster recovery than surgery, says Hamid Mojibian, MD, a Yale Medicine interventional radiologist. […] Yale also offers a new uterine fibroid treatment method called laparoscopic radiofrequency ablation, in which heat is used to significantly shrink the fibroid. […] At Yale, our interventional radiologists, gynecologists, and primary care physicians all work together to help make the best treatment plan for our patients, Dr. Mojibian says.
- #81 Treatment for uterine fibroids often depend on patient preferenceshttps://www.uabmedicine.org/news/treatment-options-for-uterine-fibroids-often-depend-on-patient-preferences/
In addition to hysterectomy, three of the most common treatments include: Myomectomy: Performed by an OB/GYN, this is a surgical option for removing fibroids, usually when they are larger and small in number. […] Radiofrequency ablation: With this minimally invasive procedure, doctors use heat from radiofrequency waves to destroy fibroid tissue. […] Uterine fibroid embolization (UFE): Performed by an interventional radiologist, this minimally invasive procedure involves starving the fibroids of the blood flow they need to survive. […] We have the advantage of being able to counsel our patients on all options, which we offer in house, whether they come in through a UAB OB/GYN, a referral from UAB Interventional Radiology, from another physician, or self-referral, Dr. Caridi said.