Materiały źródłowe

• #1 Posterior cortical atrophy | UM Health-Sparrow

  https://www.uofmhealthsparrow.org/departments-conditions/conditions/posterior-cortical-atrophy

  There are no treatments to cure or slow the progression of posterior cortical atrophy. Some research suggests that medicines used to slow the progression of Alzheimer’s disease may help manage symptoms of posterior cortical atrophy. However, this hasn’t been proved, and more research is needed. […] Some therapies and medicines can help manage the condition. They may include: […] Medicines. Your health care provider may give you medicines to treat symptoms such as depression or anxiety. […] Physical, occupational or cognitive therapy. These therapies may help you regain or retain skills that are affected by posterior cortical atrophy.

• #2 Posterior Cortical Atrophy (PCA) | Symptoms & Treatments | alz.org

  https://www.alz.org/alzheimers-dementia/what-is-dementia/types-of-dementia/posterior-cortical-atrophy

  There are no treatments for posterior cortical atrophy known to slow or halt its progression. […] Because posterior cortical atrophy resembles Alzheimers disease in some patients, it has been suggested that drugs used to temporarily alleviate brain dysfunction in Alzheimers disease may be helpful in posterior cortical atrophy, but this is not proven. […] Some people with posterior cortical atrophy may benefit from treatment to alleviate symptoms such as depression or anxiety, but the overall benefits and risks of such treatments are not established.

• #3 Posterior cortical atrophy treatment – Alzheimer’s Research UK

  https://www.alzheimersresearchuk.org/dementia-information/types-of-dementia/posterior-cortical-atrophy/treatment/

  While there are currently no specific treatments that can stop or slow down PCA, there may be medicines that can help with the symptoms. […] If Alzheimer’s disease is causing a person’s PCA they might be offered drugs called cholinesterase inhibitors. […] These drugs work by helping brain cells to communicate with each other. They may help to improve a person’s symptoms for a time, but they do not stop the disease from getting worse. […] Some people who have PCA caused by dementia with Lewy bodies (DLB) may benefit from treatments that can help with movement problems. […] Your doctor may also prescribe drug and non-drug treatments to help people with symptoms like depression and anxiety.

• #4 What is Posterior Cortical Atrophy?

  https://www.caremark.co.uk/guildford-and-woking/news/what-is-posterior-cortical-atrophy/

  Currently, there is no cure for posterior cortical atrophy (PCA), and treatment focuses on managing symptoms, optimising cognitive function, and improving quality of life. Management strategies may include: […] While there are no specific medications approved for the treatment of PCA, medications used to manage symptoms of Alzheimers disease, such as cholinesterase inhibitors (e.g., donepezil, rivastigmine) or memantine, may be prescribed to help alleviate cognitive and behavioural symptoms. […] By raising awareness of PCA and promoting research into its underlying mechanisms and treatment options, we can improve outcomes and support individuals living with this challenging condition.

• #5 Diagnosis and Management of Posterior Cortical Atrophy

  https://pmc.ncbi.nlm.nih.gov/articles/PMC9935654/

  The study aims to provide a summary of recent developments for diagnosing and managing posterior cortical atrophy (PCA). […] Current treatment of PCA is symptomatic pharmacological and non-pharmacological and the use of most treatment options is based on small studies or expert opinion. […] Recommendations for non-pharmacological approaches include interdisciplinary management tailored to the PCA clinical profile visual-spatial rather than memory-led, predominantly young onset and psychosocial implications. […] Currently, management should be tailored to each individual’s symptoms and particular challenges associated with PCA. […] Interdisciplinary management of PCA is key, and may involve a range of professionals across ophthalmology, neurology, psychiatry, allied health and social care disciplines.

• #6 Diagnosis and Management of Posterior Cortical Atrophy

  https://pmc.ncbi.nlm.nih.gov/articles/PMC9935654/

  The study aims to provide a summary of recent developments for diagnosing and managing posterior cortical atrophy (PCA). […] Current treatment of PCA is symptomatic pharmacological and non-pharmacological and the use of most treatment options is based on small studies or expert opinion. […] Recommendations for non-pharmacological approaches include interdisciplinary management tailored to the PCA clinical profile visual-spatial rather than memory-led, predominantly young onset and psychosocial implications. […] Currently, management should be tailored to each individual’s symptoms and particular challenges associated with PCA. […] Interdisciplinary management of PCA is key, and may involve a range of professionals across ophthalmology, neurology, psychiatry, allied health and social care disciplines.

• #7

  https://link.springer.com/article/10.1007/s11940-022-00745-0

  PCA diagnosis is frequently delayed, and people are likely to receive misdiagnoses of ocular or psychological conditions. Current treatment of PCA is symptomatic pharmacological and non-pharmacological and the use of most treatment options is based on small studies or expert opinion. Recommendations for non-pharmacological approaches include interdisciplinary management tailored to the PCA clinical profile visual-spatial rather than memory-led, predominantly young onset and psychosocial implications. […] Given their shared neuropathological profile, most individuals with PCA-AD should in principle benefit from symptomatic or future disease-modifying treatments with proven efficacy in typical AD. However, not only are pharmacological intervention studies in PCA very limited, but also questions remain regarding both eligibility and suitability of PCA participants for conventional clinical trials.

• #8 Diagnosis and Management of Posterior Cortical Atrophy

  https://pmc.ncbi.nlm.nih.gov/articles/PMC9935654/

  Given their shared neuropathological profile, most individuals with PCA-AD should in principle benefit from symptomatic or future disease-modifying treatments with proven efficacy in typical AD. […] The pharmacological management of PCA intersects with typical AD. […] The recent accelerated approval of aducanumab, an amyloid- targeting monoclonal antibody, by the US Food and Drug Administration was accompanied by appropriate use recommendations from an expert panel. […] As with other dementias, advice regarding strategies and aids must be tailored to the individual, their condition (severity and symptom profile) and environment (social and physical), ideally with the involvement of an interdisciplinary clinical or support team.

• #9 Posterior cortical atrophy (PCA) | Dementia Australia

  https://www.dementia.org.au/about-dementia/posterior-cortical-atrophy-pca

  There is no medication to treat posterior cortical atrophy specifically, and there’s no known cure yet. […] Your doctor may prescribe medications used to treat Alzheimers disease. They can treat the symptoms of PCA, and they may slow its progression. […] Psychological therapies or antidepressant medication may be used to improve low mood, depression, irritability, frustration and loss of self-confidence. […] Visual aids can help you with visual impairment. You can try talking clocks or watches, mobile phones with simplified displays, cooking aids such as sensors that beep when a cup is almost full and audio books. […] Occupational therapy can help people find ways to adapt to changes in abilities and maintain independence and wellbeing.

• #10 Posterior cortical atrophy | Alzheimer’s Society

  https://www.alzheimers.org.uk/about-dementia/types-dementia/Posterior-cortical-atrophy

  There are no specific medications for the treatment of PCA but some people find medications for Alzheimer’s disease helpful. […] Edward Bushnell in Oxfordshire, who is 62 and has posterior cortical atrophy, says he has no alternative but to be positive. He explains how he manages his symptoms.

• #11 Posterior Cortical Atrophy | Memory and Aging Center

  https://memory.ucsf.edu/tl/node/7601

  Although no cure for posterior cortical atrophy exists, several medications, as well as many non-pharmaceutical approaches, can potentially improve daily functioning and quality of life. Patients with posterior cortical atrophy can often benefit from physical and occupational therapy. […] Cholinesterase inhibitors approved for Alzheimers disease, like donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), can help the symptoms of PCA by boosting the function of brain cells to compensate for damage caused by Alzheimers disease. […] Patients experiencing depression, irritability, frustration, and a loss of self-confidence may benefit from antidepressant medication.

• #12

  https://www.brain.northwestern.edu/dementia/pca/care-treatment.html

  Though there is no cure for this syndrome, some medications and lifestyle modifications are available. […] If Alzheimers or Lewy Body Disease is causing the syndrome of PCA an acetylcholinesterase inhibitor (most commonly: donepezil) is used to slow the course of the disease. In the case of Alzheimers Disease, memantine is often added later on. […] Frequent exercise and diets rich in plants are beneficial as well. […] Patients and families should may work with an occupational therapist to develop compensation strategies tailored to each patients individual deficits. […] In general, patients benefit from reduced clutter around the house, non-visual cues, and greater supervision with demanding or potentially dangerous tasks such as cooking. […] Each patient with PCA should talk with their doctor to determine if they are safe to drive. […] Social workers also provide essential support to patients and families throughout the course of the disease.

• #13 Posterior Cortical Atrophy: What It Is, Symptoms & Treatment

  https://my.clevelandclinic.org/health/diseases/posterior-cortical-atrophy

  Healthcare providers cant cure it, but they can recommend medication and supportive services to reduce its symptoms. […] Healthcare providers treat posterior cortical atrophy by diagnosing and treating the underlying causes Alzheimers disease or Lewy body dementia. They may use medications that the U.S. Food and Drug Administration has approved for use in treating those conditions. These medications help to slow down the disease. […] Providers may emphasize programs and services that focus on cognitive rehabilitation, occupational and physical rehabilitation for coping strategies and mental health support. […] You may receive one of the following: Donepezil (Aricept). Rivagstigmine (Exelon). Galantamine (Reminyl). Lecanemab (Leqembi). […] If you experience anxiety or depression, you may receive anti-anxiety medication or antidepressants.

• #14

  https://www.brain.northwestern.edu/dementia/pca/care-treatment.html

  Though there is no cure for this syndrome, some medications and lifestyle modifications are available. […] If Alzheimers or Lewy Body Disease is causing the syndrome of PCA an acetylcholinesterase inhibitor (most commonly: donepezil) is used to slow the course of the disease. In the case of Alzheimers Disease, memantine is often added later on. […] Frequent exercise and diets rich in plants are beneficial as well. […] Patients and families should may work with an occupational therapist to develop compensation strategies tailored to each patients individual deficits. […] In general, patients benefit from reduced clutter around the house, non-visual cues, and greater supervision with demanding or potentially dangerous tasks such as cooking. […] Each patient with PCA should talk with their doctor to determine if they are safe to drive. […] Social workers also provide essential support to patients and families throughout the course of the disease.

• #15 Posterior cortical atrophy – Wikipedia

  https://en.wikipedia.org/wiki/Posterior_cortical_atrophy

  Specific and accepted treatment for PCA has yet to be discovered; this may be due to the rarity and variations of the disease. At times people with PCA are treated with AD treatments, such as cholinesterase inhibitors: donepezil, rivastigmine, galantamine, and also memantine. Antidepressant drugs have also provided some positive effects. […] Other treatments such as occupational therapy, or help with adapting to visual changes may help. Visual and tactile cues, adaptive equipment and digital aids to manipulate text may all be beneficial. People with PCA and their caregivers are likely to have different needs than the more typical cases of Alzheimer’s disease, and may benefit from specialized support groups, or other groups for young people with dementia. No study to date has been definitive to provide accepted conclusive analysis on treatment options.

• #16 Posterior Cortical Atrophy: What It Is, Symptoms & Treatment

  https://my.clevelandclinic.org/health/diseases/posterior-cortical-atrophy

  Healthcare providers cant cure it, but they can recommend medication and supportive services to reduce its symptoms. […] Healthcare providers treat posterior cortical atrophy by diagnosing and treating the underlying causes Alzheimers disease or Lewy body dementia. They may use medications that the U.S. Food and Drug Administration has approved for use in treating those conditions. These medications help to slow down the disease. […] Providers may emphasize programs and services that focus on cognitive rehabilitation, occupational and physical rehabilitation for coping strategies and mental health support. […] You may receive one of the following: Donepezil (Aricept). Rivagstigmine (Exelon). Galantamine (Reminyl). Lecanemab (Leqembi). […] If you experience anxiety or depression, you may receive anti-anxiety medication or antidepressants.

• #17 Posterior cortical atrophy – Wikipedia

  https://en.wikipedia.org/wiki/Posterior_cortical_atrophy

  Specific and accepted treatment for PCA has yet to be discovered; this may be due to the rarity and variations of the disease. At times people with PCA are treated with AD treatments, such as cholinesterase inhibitors: donepezil, rivastigmine, galantamine, and also memantine. Antidepressant drugs have also provided some positive effects. […] Other treatments such as occupational therapy, or help with adapting to visual changes may help. Visual and tactile cues, adaptive equipment and digital aids to manipulate text may all be beneficial. People with PCA and their caregivers are likely to have different needs than the more typical cases of Alzheimer’s disease, and may benefit from specialized support groups, or other groups for young people with dementia. No study to date has been definitive to provide accepted conclusive analysis on treatment options.

• #18 Posterior Cortical Atrophy | Memory and Aging Center

  https://memory.ucsf.edu/tl/node/7601

  Although no cure for posterior cortical atrophy exists, several medications, as well as many non-pharmaceutical approaches, can potentially improve daily functioning and quality of life. Patients with posterior cortical atrophy can often benefit from physical and occupational therapy. […] Cholinesterase inhibitors approved for Alzheimers disease, like donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), can help the symptoms of PCA by boosting the function of brain cells to compensate for damage caused by Alzheimers disease. […] Patients experiencing depression, irritability, frustration, and a loss of self-confidence may benefit from antidepressant medication.

• #19 A double-blind placebo-controlled cross-over clinical trial of DONepezil In Posterior cortical atrophy due to underlying Alzheimer’s Disease: DONIPAD study | Alzheimer’s Research & Therapy | Full Text

  https://alzres.biomedcentral.com/articles/10.1186/s13195-018-0363-1

  The study investigated whether donepezil exerts symptomatic benefit in patients with posterior cortical atrophy (PCA), an atypical variant of Alzheimers disease. […] A single-centre, double-blind, placebo-controlled, cross-over clinical trial was performed to assess the efficacy of donepezil in patients with PCA. […] This study assessed the efficacy of donepezil, a licensed AChEI, in patients with PCA due to underlying AD. […] In this small study, there was no statistically significant treatment effect of donepezil on the primary outcome measure (MMSE score at 12 weeks) in PCA patients, who appear to be particularly susceptible to the development of nightmares and vivid dreams when treated. […] However, since this is a small cross-over trial, all of our results, both positive and negative, must be interpreted cautiously.

• #20 The Progression of Posterior Cortical Atrophy to Corticobasal Syndrome: Lumping or Splitting Neurodegenerative Diseases? | Tremor and Other Hyperkinetic Movements

  https://tremorjournal.org/articles/10.5334/tohm.207

  Posterior cortical atrophy is a clinical syndrome that is characterized by the progressive loss of visuospatial integration and is associated with neurodegenerative conditions. […] The patient began treatment with rivastigmine (4.6mg/day). This treatment was subsequently slowly titrated up to 9.5mg/day in the belief that she might have been affected by the posterior variant of AD. […] Unfortunately, the pharmacologic response to rivastigmine was lacking. […] These diagnostic criteria are based on clinical signs and symptoms that are not informative about the actual underlying degenerative condition, and show poor clinic-pathological correlations. […] The empowerment of histopathology-targeted diagnostic protocols for neurodegenerative diseases is highly desirable and should be achieved using disease-specific biomarkers.

• #21 A double-blind placebo-controlled cross-over clinical trial of DONepezil In Posterior cortical atrophy due to underlying Alzheimer’s Disease: DONIPAD study | Alzheimer’s Research & Therapy | Full Text

  https://alzres.biomedcentral.com/articles/10.1186/s13195-018-0363-1

  In our primary analysis there was no statistically significant treatment effect of donepezil on the primary outcome measure: change in MMSE at 12 weeks. […] Known common gastrointestinal side effects of donepezil occurred in the course of the study. The frequency of nightmares and vivid dreams occurred significantly more commonly in association with donepezil treatment, and possibly more commonly than reported previously in patients with the typical amnestic presentation of AD. Patients with PCA may be particularly vulnerable to these side effects.

• #22

  https://www.brain.northwestern.edu/dementia/pca/care-treatment.html

  Though there is no cure for this syndrome, some medications and lifestyle modifications are available. […] If Alzheimers or Lewy Body Disease is causing the syndrome of PCA an acetylcholinesterase inhibitor (most commonly: donepezil) is used to slow the course of the disease. In the case of Alzheimers Disease, memantine is often added later on. […] Frequent exercise and diets rich in plants are beneficial as well. […] Patients and families should may work with an occupational therapist to develop compensation strategies tailored to each patients individual deficits. […] In general, patients benefit from reduced clutter around the house, non-visual cues, and greater supervision with demanding or potentially dangerous tasks such as cooking. […] Each patient with PCA should talk with their doctor to determine if they are safe to drive. […] Social workers also provide essential support to patients and families throughout the course of the disease.

• #23 Posterior cortical atrophy – Wikipedia

  https://en.wikipedia.org/wiki/Posterior_cortical_atrophy

  Specific and accepted treatment for PCA has yet to be discovered; this may be due to the rarity and variations of the disease. At times people with PCA are treated with AD treatments, such as cholinesterase inhibitors: donepezil, rivastigmine, galantamine, and also memantine. Antidepressant drugs have also provided some positive effects. […] Other treatments such as occupational therapy, or help with adapting to visual changes may help. Visual and tactile cues, adaptive equipment and digital aids to manipulate text may all be beneficial. People with PCA and their caregivers are likely to have different needs than the more typical cases of Alzheimer’s disease, and may benefit from specialized support groups, or other groups for young people with dementia. No study to date has been definitive to provide accepted conclusive analysis on treatment options.

• #24 Posterior Cortical Atrophy | Memory and Aging Center

  https://memory.ucsf.edu/tl/node/7601

  Although no cure for posterior cortical atrophy exists, several medications, as well as many non-pharmaceutical approaches, can potentially improve daily functioning and quality of life. Patients with posterior cortical atrophy can often benefit from physical and occupational therapy. […] Cholinesterase inhibitors approved for Alzheimers disease, like donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), can help the symptoms of PCA by boosting the function of brain cells to compensate for damage caused by Alzheimers disease. […] Patients experiencing depression, irritability, frustration, and a loss of self-confidence may benefit from antidepressant medication.

• #25 Posterior cortical atrophy | UM Health-Sparrow

  https://www.uofmhealthsparrow.org/departments-conditions/conditions/posterior-cortical-atrophy

  There are no treatments to cure or slow the progression of posterior cortical atrophy. Some research suggests that medicines used to slow the progression of Alzheimer’s disease may help manage symptoms of posterior cortical atrophy. However, this hasn’t been proved, and more research is needed. […] Some therapies and medicines can help manage the condition. They may include: […] Medicines. Your health care provider may give you medicines to treat symptoms such as depression or anxiety. […] Physical, occupational or cognitive therapy. These therapies may help you regain or retain skills that are affected by posterior cortical atrophy.

• #26 Posterior Cortical Atrophy | Treatment & Management | Point of Care

  https://www.statpearls.com/point-of-care/132241

  Pharmacological management: Data on anticholinesterase inhibitors in PCA is lacking. However, since the majority of the cases of PCA are secondary to underlying AD pathology, targeting the underlying pathophysiology using anticholinesterase inhibitors and memantine is an appropriate choice. There are individual case reports that describe the responsiveness of PCA to anticholinesterase inhibitors.[23] (B3) […] As the visual impairment progresses with preservation of insight and the emergence of increasing dependence, patients commonly deal with significant feelings of overwhelming anxiety and depression.[24] Patients may benefit from selective serotonin reuptake inhibitors (SSRIs) to cope with anxiety and mood changes. […] Non-pharmacological management: The mainstay of the treatment approach is non-pharmacological, with interventions geared toward providing more coping strategies, psychological support, and care.[17] The goal would be to compensate at least partially for deficits with improved daily functioning, everyday skills, self-care, and quality of life.[25] (B3) […] It is of paramount importance that an early diagnosis is made so that safety measures are implemented on time, such as ensuring safety by avoiding driving, removing unsafe furniture, and ensuring safety adaptations to the home settings. Encouraging audiobooks can help compensate for deficits in reading as the disease progresses. […] Use of voice recognition, smartphone apps, labeling around doorknobs and hallways, home adaptions in the kitchen, bathroom, and staircase can help compensate for the visuospatial deficits and navigate everyday living. In addition, referring patients and families to support groups for PCA can immensely benefit.

• #27 Posterior Cortical Atrophy – MD Searchlight

  https://mdsearchlight.com/neurology/posterior-cortical-atrophy/

  While we dont have a lot of information about the use of certain medications known as anticholinesterase inhibitors in patients with Posterior Cortical Atrophy (PCA), they might be beneficial for treating PCA because it often results from an underlying condition called Alzheimers disease. These drugs, along with another one called memantine, target the root cause of the symptoms. There have been some reports of PCA patients responding positively to anticholinesterase inhibitors. […] As PCA progresses, it often leads to problems with vision while the patients awareness remains unaffected. This situation can cause a lot of stress, anxiety, and depression for the patient. Thats why it could be helpful to use medications known as selective serotonin reuptake inhibitors (SSRIs), which are commonly used to treat anxiety and mood changes.

• #28 Posterior Cortical Atrophy: What It Is, Symptoms & Treatment

  https://my.clevelandclinic.org/health/diseases/posterior-cortical-atrophy

  Healthcare providers cant cure it, but they can recommend medication and supportive services to reduce its symptoms. […] Healthcare providers treat posterior cortical atrophy by diagnosing and treating the underlying causes Alzheimers disease or Lewy body dementia. They may use medications that the U.S. Food and Drug Administration has approved for use in treating those conditions. These medications help to slow down the disease. […] Providers may emphasize programs and services that focus on cognitive rehabilitation, occupational and physical rehabilitation for coping strategies and mental health support. […] You may receive one of the following: Donepezil (Aricept). Rivagstigmine (Exelon). Galantamine (Reminyl). Lecanemab (Leqembi). […] If you experience anxiety or depression, you may receive anti-anxiety medication or antidepressants.

• #29 Posterior Cortical Atrophy: What It Is, Symptoms & Treatment

  https://my.clevelandclinic.org/health/diseases/posterior-cortical-atrophy

  Healthcare providers cant cure it, but they can recommend medication and supportive services to reduce its symptoms. […] Healthcare providers treat posterior cortical atrophy by diagnosing and treating the underlying causes Alzheimers disease or Lewy body dementia. They may use medications that the U.S. Food and Drug Administration has approved for use in treating those conditions. These medications help to slow down the disease. […] Providers may emphasize programs and services that focus on cognitive rehabilitation, occupational and physical rehabilitation for coping strategies and mental health support. […] You may receive one of the following: Donepezil (Aricept). Rivagstigmine (Exelon). Galantamine (Reminyl). Lecanemab (Leqembi). […] If you experience anxiety or depression, you may receive anti-anxiety medication or antidepressants.

• #30 Azthena logo with the word Azthena

  https://www.news-medical.net/news/20240122/Posterior-cortical-atrophy-predicts-Alzheimers-study-finds.aspx

  We need better tools and training to identify patients […] Early identification of PCA may have important implications for Alzheimer’s treatment, said co-first author Renaud La Joie, Ph.D., also of the UCSF Department of Neurology and the Memory and Aging Center. In the study, levels of amyloid and tau, identified in cerebrospinal fluid and imaging, as well as autopsy data, matched those found in typical Alzheimer’s cases. As a result, patients with PCA may be candidates for anti-amyloid therapies, like lecanemab (Leqembi), approved by the U.S Food and Drug Administration in January 2023, and anti-tau therapies, currently in clinical trials, both of which are believed to be more effective in the earliest phases of the disease, he said. […] Patients have mostly been excluded from trials, since they are „usually aimed at patients with amnestic Alzheimer’s with low scores on memory tests,” La Joie added. „However, at UCSF we are considering treatments for patients with PCA and other non-amnestic variants.”

• #31

  https://link.springer.com/article/10.1007/s11940-022-00745-0

  The pharmacological management of PCA intersects with typical AD. […] The recent accelerated approval of aducanumab, an amyloid- targeting monoclonal antibody, by the US Food and Drug Administration was accompanied by appropriate use recommendations from an expert panel. […] As with other dementias, advice regarding strategies and aids must be tailored to the individual, their condition (severity and symptom profile) and environment (social and physical), ideally with the involvement of an interdisciplinary clinical or support team.

• #32 Diagnosis and Management of Posterior Cortical Atrophy

  https://pmc.ncbi.nlm.nih.gov/articles/PMC9935654/

  Given their shared neuropathological profile, most individuals with PCA-AD should in principle benefit from symptomatic or future disease-modifying treatments with proven efficacy in typical AD. […] The pharmacological management of PCA intersects with typical AD. […] The recent accelerated approval of aducanumab, an amyloid- targeting monoclonal antibody, by the US Food and Drug Administration was accompanied by appropriate use recommendations from an expert panel. […] As with other dementias, advice regarding strategies and aids must be tailored to the individual, their condition (severity and symptom profile) and environment (social and physical), ideally with the involvement of an interdisciplinary clinical or support team.

• #33 Azthena logo with the word Azthena

  https://www.news-medical.net/news/20240122/Posterior-cortical-atrophy-predicts-Alzheimers-study-finds.aspx

  We need better tools and training to identify patients […] Early identification of PCA may have important implications for Alzheimer’s treatment, said co-first author Renaud La Joie, Ph.D., also of the UCSF Department of Neurology and the Memory and Aging Center. In the study, levels of amyloid and tau, identified in cerebrospinal fluid and imaging, as well as autopsy data, matched those found in typical Alzheimer’s cases. As a result, patients with PCA may be candidates for anti-amyloid therapies, like lecanemab (Leqembi), approved by the U.S Food and Drug Administration in January 2023, and anti-tau therapies, currently in clinical trials, both of which are believed to be more effective in the earliest phases of the disease, he said. […] Patients have mostly been excluded from trials, since they are „usually aimed at patients with amnestic Alzheimer’s with low scores on memory tests,” La Joie added. „However, at UCSF we are considering treatments for patients with PCA and other non-amnestic variants.”

• #34 Posterior cortical atrophy treatment – Alzheimer’s Research UK

  https://www.alzheimersresearchuk.org/dementia-information/types-of-dementia/posterior-cortical-atrophy/treatment/

  While there are currently no specific treatments that can stop or slow down PCA, there may be medicines that can help with the symptoms. […] If Alzheimer’s disease is causing a person’s PCA they might be offered drugs called cholinesterase inhibitors. […] These drugs work by helping brain cells to communicate with each other. They may help to improve a person’s symptoms for a time, but they do not stop the disease from getting worse. […] Some people who have PCA caused by dementia with Lewy bodies (DLB) may benefit from treatments that can help with movement problems. […] Your doctor may also prescribe drug and non-drug treatments to help people with symptoms like depression and anxiety.

• #35 Posterior Cortical Atrophy – Symptoms and causes – Apollo Hospitals

  https://www.apollohospitals.com/diseases-and-conditions/posterior-cortical-atrophy/

  Depending on the cause and severity of posterior cortical atrophy, your doctor may recommend a treatment plan. […] If Alzheimers disease is the cause of your posterior cortical atrophy, the doctor may recommend a medication known as cholinesterase inhibitors. These medications work by making your brain cells communicate with one another. Although the medication may improve your symptoms temporarily, it may not stop your posterior cortical atrophy from worsening. […] Suppose you have posterior cortical atrophy and dementia with Lewy bodies. In that case, you may benefit from treatment options that help with your movement problems. For this, the doctor may recommend a drug known as levodopa. It is used to treat Parkinsons disease and in some cases dementia with Lewy bodies. […] If your symptoms involve anxiety or depression, your doctor may recommend drug or non-drug treatments. Cognitive-behavioral therapy is one of the standard treatment options for depression and anxiety in posterior cortical atrophy. The therapy will allow you to talk about your worries and concerns with your therapist.

• #36 Non-pharmacological intervention for posterior cortical atrophy

  https://www.wjgnet.com/2307-8960/full/v4/i8/195.htm

  Non-pharmacological intervention for posterior cortical atrophy […] Non-pharmacological interventions remain scarcely explored as therapies for posterior cortical atrophy (PCA). Preliminary evidence suggests the potential of cognitive rehabilitation and psychoeducation. There is a need for randomized controlled trials evaluating the efficacy and cost-effectiveness of non-pharmacological approaches in PCA. […] Despite a relatively well-known neurocognitive profile, non-pharmacological intervention in PCA is still rarely described or implemented, even though it is recommended since its benefits are encouraging for the PCA patients daily life. […] In the available literature, two types of intervention approaches have been reported previously: (1) cognitive rehabilitation programs, aiming at maximizing patient cognition and functionality; and (2) psycho-educative programs that consist of a didactic and therapeutic approach for people with PCA and their caregivers with the aim of facilitating coping, understanding of the disease, and reducing its impact in daily life.

• #37

  https://link.springer.com/article/10.1007/s11940-022-00745-0

  The pharmacological management of PCA intersects with typical AD. […] The recent accelerated approval of aducanumab, an amyloid- targeting monoclonal antibody, by the US Food and Drug Administration was accompanied by appropriate use recommendations from an expert panel. […] As with other dementias, advice regarding strategies and aids must be tailored to the individual, their condition (severity and symptom profile) and environment (social and physical), ideally with the involvement of an interdisciplinary clinical or support team.

• #38 Occupational Therapy for Posterior Cortical Atrophy

  https://occupationaltherapybrisbane.com.au/occupational-therapy-for-posterior-cortical-atrophy/

  Occupational therapy plays a crucial role in managing the functional status of individuals with PCA by conducting comprehensive assessments and developing personalized cognitive rehabilitation programs to promote independence and enhance everyday skills. […] Occupational therapy plays a pivotal role in the treatment of individuals with Posterior Cortical Atrophy (PCA), addressing both visual impairments and cognitive challenges that affect daily life. […] Our therapists specialize in mitigating these visual symptoms and enhancing cognitive functions through targeted strategies and interventions. […] We employ a combination of cognitive interventions, visual exercises, and activities of daily living tailored to each patient’s unique needs. […] Strategies are developed in close collaboration with patients to manage specific challenges such as visual crowding, optic ataxia, and visual hallucinations.

• #39

  https://www.brain.northwestern.edu/dementia/pca/care-treatment.html

  Though there is no cure for this syndrome, some medications and lifestyle modifications are available. […] If Alzheimers or Lewy Body Disease is causing the syndrome of PCA an acetylcholinesterase inhibitor (most commonly: donepezil) is used to slow the course of the disease. In the case of Alzheimers Disease, memantine is often added later on. […] Frequent exercise and diets rich in plants are beneficial as well. […] Patients and families should may work with an occupational therapist to develop compensation strategies tailored to each patients individual deficits. […] In general, patients benefit from reduced clutter around the house, non-visual cues, and greater supervision with demanding or potentially dangerous tasks such as cooking. […] Each patient with PCA should talk with their doctor to determine if they are safe to drive. […] Social workers also provide essential support to patients and families throughout the course of the disease.

• #40 Posterior Cortical Atrophy | Stellar Care

  https://stellarcaresd.com/posterior-cortical-atrophy/

  Currently, there is no cure for Posterior Cortical Atrophy (PCA), and treatment focuses on managing its symptoms and providing support to enhance the individuals quality of life. Some approaches commonly used in the treatment of PCA are: […] Medications may be prescribed to manage specific symptoms of PCA. These can include medications to address visual disturbances, sleep disturbances, depression, or anxiety. […] Occupational therapists can help people with PCA develop strategies to cope with daily tasks affected by visual and cognitive difficulties. These include techniques to improve spatial awareness, organization, and adaptive strategies for activities of daily living. […] Visual aids such as magnifiers, large-print materials, and electronic devices with text-to-speech capabilities can assist individuals with PCA in reading and other visual tasks.

• #41 Posterior cortical atrophy (PCA) | Dementia Australia

  https://www.dementia.org.au/about-dementia/posterior-cortical-atrophy-pca

  There is no medication to treat posterior cortical atrophy specifically, and there’s no known cure yet. […] Your doctor may prescribe medications used to treat Alzheimers disease. They can treat the symptoms of PCA, and they may slow its progression. […] Psychological therapies or antidepressant medication may be used to improve low mood, depression, irritability, frustration and loss of self-confidence. […] Visual aids can help you with visual impairment. You can try talking clocks or watches, mobile phones with simplified displays, cooking aids such as sensors that beep when a cup is almost full and audio books. […] Occupational therapy can help people find ways to adapt to changes in abilities and maintain independence and wellbeing.

• #42 Occupational Therapy for Posterior Cortical Atrophy

  https://occupationaltherapybrisbane.com.au/occupational-therapy-for-posterior-cortical-atrophy/

  Occupational therapy plays a crucial role in managing the functional status of individuals with PCA by conducting comprehensive assessments and developing personalized cognitive rehabilitation programs to promote independence and enhance everyday skills. […] Occupational therapy plays a pivotal role in the treatment of individuals with Posterior Cortical Atrophy (PCA), addressing both visual impairments and cognitive challenges that affect daily life. […] Our therapists specialize in mitigating these visual symptoms and enhancing cognitive functions through targeted strategies and interventions. […] We employ a combination of cognitive interventions, visual exercises, and activities of daily living tailored to each patient’s unique needs. […] Strategies are developed in close collaboration with patients to manage specific challenges such as visual crowding, optic ataxia, and visual hallucinations.

• #43 Occupational Therapy for Posterior Cortical Atrophy

  https://occupationaltherapybrisbane.com.au/occupational-therapy-for-posterior-cortical-atrophy/

  Occupational therapy plays a crucial role in managing the functional status of individuals with PCA by conducting comprehensive assessments and developing personalized cognitive rehabilitation programs to promote independence and enhance everyday skills. […] Occupational therapy plays a pivotal role in the treatment of individuals with Posterior Cortical Atrophy (PCA), addressing both visual impairments and cognitive challenges that affect daily life. […] Our therapists specialize in mitigating these visual symptoms and enhancing cognitive functions through targeted strategies and interventions. […] We employ a combination of cognitive interventions, visual exercises, and activities of daily living tailored to each patient’s unique needs. […] Strategies are developed in close collaboration with patients to manage specific challenges such as visual crowding, optic ataxia, and visual hallucinations.

• #44 Non-pharmacological intervention for posterior cortical atrophy

  https://www.wjgnet.com/2307-8960/full/v4/i8/195.htm

  Non-pharmacological intervention for posterior cortical atrophy […] Non-pharmacological interventions remain scarcely explored as therapies for posterior cortical atrophy (PCA). Preliminary evidence suggests the potential of cognitive rehabilitation and psychoeducation. There is a need for randomized controlled trials evaluating the efficacy and cost-effectiveness of non-pharmacological approaches in PCA. […] Despite a relatively well-known neurocognitive profile, non-pharmacological intervention in PCA is still rarely described or implemented, even though it is recommended since its benefits are encouraging for the PCA patients daily life. […] In the available literature, two types of intervention approaches have been reported previously: (1) cognitive rehabilitation programs, aiming at maximizing patient cognition and functionality; and (2) psycho-educative programs that consist of a didactic and therapeutic approach for people with PCA and their caregivers with the aim of facilitating coping, understanding of the disease, and reducing its impact in daily life.

• #45 Non-pharmacological intervention for posterior cortical atrophy

  https://www.wjgnet.com/2307-8960/full/v4/i8/195.htm

  Cognitive rehabilitation has shown evidence of efficacy in the treatment of cognitive disorders acquired after stroke. Indeed, this intervention approach has also shown some evidence of efficacy in people with AD. […] Cognitive rehabilitation programs have been successful at partially remediating cognitive impairments and improving functionality in PCA, whereas the contribution of isolated psycho-educative intervention was moderate. […] Strengthening residual abilities might contribute to decreased errors in daily life and, as profiled above, to enhance the quality of life. […] Therefore, based on our current knowledge, cognitive rehabilitation programs designed for PCA subjects could include the following: (1) a psycho-educative intervention component, with the aim of explaining neurological mechanisms underlying the troubles experienced by the patients and their caregivers; (2) stimulation/maximization/development of preserved abilities, either in activities of daily life and/or in visual situations. […] In summary, the current research in the field of dementia suggests that PCA patients show relative preserved insight in the early and moderate stages, and preliminary evidence showing promising effects for non-pharmacological interventions in PCA warrant future research.

• #46 Occupational Therapy for Posterior Cortical Atrophy

  https://occupationaltherapybrisbane.com.au/occupational-therapy-for-posterior-cortical-atrophy/

  Cognitive decline associated with PCA is addressed through neuropsychological or cognitive rehabilitation programs. […] Through rehabilitation, patients with PCA have learned to recognize and use their preserved abilities, leading to fewer daily errors and improved autonomy, which enhances their quality of life.

• #47 Occupational Therapy for Posterior Cortical Atrophy

  https://occupationaltherapybrisbane.com.au/occupational-therapy-for-posterior-cortical-atrophy/

  Cognitive decline associated with PCA is addressed through neuropsychological or cognitive rehabilitation programs. […] Through rehabilitation, patients with PCA have learned to recognize and use their preserved abilities, leading to fewer daily errors and improved autonomy, which enhances their quality of life.

• #48 Non-pharmacological intervention for posterior cortical atrophy

  https://www.wjgnet.com/2307-8960/full/v4/i8/195.htm

  Cognitive rehabilitation has shown evidence of efficacy in the treatment of cognitive disorders acquired after stroke. Indeed, this intervention approach has also shown some evidence of efficacy in people with AD. […] Cognitive rehabilitation programs have been successful at partially remediating cognitive impairments and improving functionality in PCA, whereas the contribution of isolated psycho-educative intervention was moderate. […] Strengthening residual abilities might contribute to decreased errors in daily life and, as profiled above, to enhance the quality of life. […] Therefore, based on our current knowledge, cognitive rehabilitation programs designed for PCA subjects could include the following: (1) a psycho-educative intervention component, with the aim of explaining neurological mechanisms underlying the troubles experienced by the patients and their caregivers; (2) stimulation/maximization/development of preserved abilities, either in activities of daily life and/or in visual situations. […] In summary, the current research in the field of dementia suggests that PCA patients show relative preserved insight in the early and moderate stages, and preliminary evidence showing promising effects for non-pharmacological interventions in PCA warrant future research.

• #49 Posterior cortical atrophy | UM Health-Sparrow

  https://www.uofmhealthsparrow.org/departments-conditions/conditions/posterior-cortical-atrophy

  There are no treatments to cure or slow the progression of posterior cortical atrophy. Some research suggests that medicines used to slow the progression of Alzheimer’s disease may help manage symptoms of posterior cortical atrophy. However, this hasn’t been proved, and more research is needed. […] Some therapies and medicines can help manage the condition. They may include: […] Medicines. Your health care provider may give you medicines to treat symptoms such as depression or anxiety. […] Physical, occupational or cognitive therapy. These therapies may help you regain or retain skills that are affected by posterior cortical atrophy.

• #50 Unlocking Hope for Neurodegenerative Conditions Using Holistic Approaches – Rocket City Chiropractic

  https://www.rocketcitychiropractic.com/unlocking-hope-for-neurodegenerative-conditions-using-holistic-approaches/

  Chiropractic care can potentially assist in the treatment of neurodegenerative diseases through the utilization of neurological rehabilitation techniques. […] Chiropractors can create personalized treatment plans for individuals with neurodegenerative diseases, tailored to their specific needs and limitations. […] Chiropractors can develop customized exercise programs tailored to the specific needs and capabilities of individuals with neurodegenerative diseases. […] Chiropractors can offer nutritional counseling to individuals with neurodegenerative diseases, providing guidance on a well-balanced diet that supports overall health and may have specific benefits for their condition. […] Through a holistic approach, chiropractic care focuses on addressing underlying neurological dysfunctions, restoring nervous system function, and enhancing brain-body communication.

• #51 Physical medicine and rehabilitation multidisciplinary approach in a case of posterior cortical atrophy | Musculoskeletal Key

  https://musculoskeletalkey.com/physical-medicine-and-rehabilitation-multidisciplinary-approach-in-a-case-of-posterior-cortical-atrophy/

  Posterior cortical atrophy (PCA) is a degenerative syndrome heralded by progressive visual and spatial disorders, while the memory and execution capacities remain preserved for a long time. […] Our objective is to highlight the interest of a multidisciplinary approach in PCA. […] A six-month multidisciplinary approach (speech therapy, occupational therapy, and physiotherapy) centered on her visual disturbances and associated to the reinforcement of her preserved abilities, as well as a rehabilitation program, was proposed. […] The specific therapeutic management allowed reaching functional objectives. […] The neurodegenerative pathologies responsible for specific instrumental disabilities without global cognitive alteration, and particularly PCA, should be able to benefit from a specific, or even multidisciplinary PMR therapy approach.

• #52 Treatment of a patient with posterior cortical atrophy (PCA) with chiropractic manipulation and Dynamic Neuromuscular Stabilization (DNS): A case report

  https://pmc.ncbi.nlm.nih.gov/articles/PMC4319453/

  Posterior cortical atrophy (PCA) is a rare progressive neurodegenerative syndrome which unusual symptoms include deficits of balance, bodily orientation, chronic pain syndrome and dysfunctional motor patterns. Current research provides minimal guidance on support, education and recommended evidence-based patient care. This case reports the utilization of chiropractic spinal manipulation, dynamic neuromuscular stabilization (DNS), and other adjunctive procedures along with medical treatment of PCA. […] Chiropractic spinal manipulation and dynamic neuromuscular stabilization were utilized as adjunctive care to conservative pharmacological treatment of PCA. Outcome measurements showed a 60% improvement in the patients perception of health with restored functional neuromuscular pattern, improvements in locomotion, posture, pain control, mood, tolerance to activities of daily living (ADLs) and overall satisfactory progress in quality of life. Yet, no changes on memory loss progression, visual space orientation, and speech were observed.

• #53 Posterior Cortical Atrophy: One 53-year-old’s Journey to Diagnosis | Being Patient

  https://www.beingpatient.com/posterior-cortical-atrophy-deb-jobe/

  Deb Jobe refused to let an early diagnosis of posterior cortical atrophy keep her from living a fulfilling, joyous life. […] I was very fortunate in my path of diagnosis, and I’m so passionate about early intervention and about getting to the doctor. […] Number one is counseling. They put me in counseling right away to come to terms with what was happening. […] The counseling helped. The support groups know you’re not alone. […] If just one person takes my advice and gets their loved one, their family member, a friend, any concern, get it checked out. […] There is so much that can be done and there is so much innovation now happening with therapies and drugs. […] Counseling, the referral to cognitive therapy, and getting local support are the top things that you absolutely should do. […] Please don’t stop doing them because that’s what brings you joy. […] Whatever your passion is, do it. Don’t waste time. […] I believe that this is what is helping me continue to live. […] Don’t lose your faith.

• #54 Posterior Cortical Atrophy – Symptoms and causes – Apollo Hospitals

  https://www.apollohospitals.com/diseases-and-conditions/posterior-cortical-atrophy/

  Depending on the cause and severity of posterior cortical atrophy, your doctor may recommend a treatment plan. […] If Alzheimers disease is the cause of your posterior cortical atrophy, the doctor may recommend a medication known as cholinesterase inhibitors. These medications work by making your brain cells communicate with one another. Although the medication may improve your symptoms temporarily, it may not stop your posterior cortical atrophy from worsening. […] Suppose you have posterior cortical atrophy and dementia with Lewy bodies. In that case, you may benefit from treatment options that help with your movement problems. For this, the doctor may recommend a drug known as levodopa. It is used to treat Parkinsons disease and in some cases dementia with Lewy bodies. […] If your symptoms involve anxiety or depression, your doctor may recommend drug or non-drug treatments. Cognitive-behavioral therapy is one of the standard treatment options for depression and anxiety in posterior cortical atrophy. The therapy will allow you to talk about your worries and concerns with your therapist.

• #55 Posterior cortical atrophy – Wikipedia

  https://en.wikipedia.org/wiki/Posterior_cortical_atrophy

  Specific and accepted treatment for PCA has yet to be discovered; this may be due to the rarity and variations of the disease. At times people with PCA are treated with AD treatments, such as cholinesterase inhibitors: donepezil, rivastigmine, galantamine, and also memantine. Antidepressant drugs have also provided some positive effects. […] Other treatments such as occupational therapy, or help with adapting to visual changes may help. Visual and tactile cues, adaptive equipment and digital aids to manipulate text may all be beneficial. People with PCA and their caregivers are likely to have different needs than the more typical cases of Alzheimer’s disease, and may benefit from specialized support groups, or other groups for young people with dementia. No study to date has been definitive to provide accepted conclusive analysis on treatment options.

• #56 Posterior Cortical Atrophy: One 53-year-old’s Journey to Diagnosis | Being Patient

  https://www.beingpatient.com/posterior-cortical-atrophy-deb-jobe/

  Deb Jobe refused to let an early diagnosis of posterior cortical atrophy keep her from living a fulfilling, joyous life. […] I was very fortunate in my path of diagnosis, and I’m so passionate about early intervention and about getting to the doctor. […] Number one is counseling. They put me in counseling right away to come to terms with what was happening. […] The counseling helped. The support groups know you’re not alone. […] If just one person takes my advice and gets their loved one, their family member, a friend, any concern, get it checked out. […] There is so much that can be done and there is so much innovation now happening with therapies and drugs. […] Counseling, the referral to cognitive therapy, and getting local support are the top things that you absolutely should do. […] Please don’t stop doing them because that’s what brings you joy. […] Whatever your passion is, do it. Don’t waste time. […] I believe that this is what is helping me continue to live. […] Don’t lose your faith.

• #57 Non-pharmacological intervention for posterior cortical atrophy

  https://www.wjgnet.com/2307-8960/full/v4/i8/195.htm

  Cognitive rehabilitation has shown evidence of efficacy in the treatment of cognitive disorders acquired after stroke. Indeed, this intervention approach has also shown some evidence of efficacy in people with AD. […] Cognitive rehabilitation programs have been successful at partially remediating cognitive impairments and improving functionality in PCA, whereas the contribution of isolated psycho-educative intervention was moderate. […] Strengthening residual abilities might contribute to decreased errors in daily life and, as profiled above, to enhance the quality of life. […] Therefore, based on our current knowledge, cognitive rehabilitation programs designed for PCA subjects could include the following: (1) a psycho-educative intervention component, with the aim of explaining neurological mechanisms underlying the troubles experienced by the patients and their caregivers; (2) stimulation/maximization/development of preserved abilities, either in activities of daily life and/or in visual situations. […] In summary, the current research in the field of dementia suggests that PCA patients show relative preserved insight in the early and moderate stages, and preliminary evidence showing promising effects for non-pharmacological interventions in PCA warrant future research.

• #58

  https://www.brain.northwestern.edu/dementia/pca/care-treatment.html

  Though there is no cure for this syndrome, some medications and lifestyle modifications are available. […] If Alzheimers or Lewy Body Disease is causing the syndrome of PCA an acetylcholinesterase inhibitor (most commonly: donepezil) is used to slow the course of the disease. In the case of Alzheimers Disease, memantine is often added later on. […] Frequent exercise and diets rich in plants are beneficial as well. […] Patients and families should may work with an occupational therapist to develop compensation strategies tailored to each patients individual deficits. […] In general, patients benefit from reduced clutter around the house, non-visual cues, and greater supervision with demanding or potentially dangerous tasks such as cooking. […] Each patient with PCA should talk with their doctor to determine if they are safe to drive. […] Social workers also provide essential support to patients and families throughout the course of the disease.

• #59

  https://www.brain.northwestern.edu/dementia/pca/care-treatment.html

  Though there is no cure for this syndrome, some medications and lifestyle modifications are available. […] If Alzheimers or Lewy Body Disease is causing the syndrome of PCA an acetylcholinesterase inhibitor (most commonly: donepezil) is used to slow the course of the disease. In the case of Alzheimers Disease, memantine is often added later on. […] Frequent exercise and diets rich in plants are beneficial as well. […] Patients and families should may work with an occupational therapist to develop compensation strategies tailored to each patients individual deficits. […] In general, patients benefit from reduced clutter around the house, non-visual cues, and greater supervision with demanding or potentially dangerous tasks such as cooking. […] Each patient with PCA should talk with their doctor to determine if they are safe to drive. […] Social workers also provide essential support to patients and families throughout the course of the disease.

• #60

  https://www.brain.northwestern.edu/dementia/pca/care-treatment.html

  Though there is no cure for this syndrome, some medications and lifestyle modifications are available. […] If Alzheimers or Lewy Body Disease is causing the syndrome of PCA an acetylcholinesterase inhibitor (most commonly: donepezil) is used to slow the course of the disease. In the case of Alzheimers Disease, memantine is often added later on. […] Frequent exercise and diets rich in plants are beneficial as well. […] Patients and families should may work with an occupational therapist to develop compensation strategies tailored to each patients individual deficits. […] In general, patients benefit from reduced clutter around the house, non-visual cues, and greater supervision with demanding or potentially dangerous tasks such as cooking. […] Each patient with PCA should talk with their doctor to determine if they are safe to drive. […] Social workers also provide essential support to patients and families throughout the course of the disease.

• #61 Posterior Cortical Atrophy | Stellar Care

  https://stellarcaresd.com/posterior-cortical-atrophy/

  People with PCA and their caregivers may benefit from counseling or support groups which provide emotional support, education, and strategies for coping with the challenges posed by PCA. […] Modifying the home environment by reducing clutter, improving lighting, and using contrasting colors can help people with PCA navigate their surroundings safely and effectively. […] As cognitive functions decline, memory aids like calendars, reminder apps, and notes can help people with PCA manage daily schedules and tasks. […] Frequent check-ups with healthcare professionals are essential to monitor the progression of PCA and adjust treatment and support strategies accordingly. […] An individual care plan should be developed to meet the specific needs and symptoms of each person with PCA. Close collaboration with neurologists, ophthalmologists, and occupational therapists, is important for managing PCA.

• #62

  https://www.brain.northwestern.edu/dementia/pca/care-treatment.html

  Though there is no cure for this syndrome, some medications and lifestyle modifications are available. […] If Alzheimers or Lewy Body Disease is causing the syndrome of PCA an acetylcholinesterase inhibitor (most commonly: donepezil) is used to slow the course of the disease. In the case of Alzheimers Disease, memantine is often added later on. […] Frequent exercise and diets rich in plants are beneficial as well. […] Patients and families should may work with an occupational therapist to develop compensation strategies tailored to each patients individual deficits. […] In general, patients benefit from reduced clutter around the house, non-visual cues, and greater supervision with demanding or potentially dangerous tasks such as cooking. […] Each patient with PCA should talk with their doctor to determine if they are safe to drive. […] Social workers also provide essential support to patients and families throughout the course of the disease.

• #63 Posterior Cortical Atrophy | Stellar Care

  https://stellarcaresd.com/posterior-cortical-atrophy/

  People with PCA and their caregivers may benefit from counseling or support groups which provide emotional support, education, and strategies for coping with the challenges posed by PCA. […] Modifying the home environment by reducing clutter, improving lighting, and using contrasting colors can help people with PCA navigate their surroundings safely and effectively. […] As cognitive functions decline, memory aids like calendars, reminder apps, and notes can help people with PCA manage daily schedules and tasks. […] Frequent check-ups with healthcare professionals are essential to monitor the progression of PCA and adjust treatment and support strategies accordingly. […] An individual care plan should be developed to meet the specific needs and symptoms of each person with PCA. Close collaboration with neurologists, ophthalmologists, and occupational therapists, is important for managing PCA.

• #64 Posterior cortical atrophy: a dementia that affects the vision — DPUK

  https://www.dementiasplatform.uk/news-and-media/blog/posterior-cortical-atrophy-a-dementia-that-affects-the-vision

  Currently, we do not know why people develop PCA or what risk factors there are for it. There is also no medication that specifically treats PCA, although some people find that drugs designed for Alzheimers disease or Parkinsons help their symptoms. […] The charity Rare Dementia Support recommends people with PCA try visual aids like sensors that inform the user when a cup is full, talking clocks, and technology with big buttons and a simple display. Controlling light levels by switching lights on before it gets dark and using lampshades to soften harsh lights can also help people with PCA to understand their surroundings better. Rare Dementia Support also provides support for people diagnosed with PCA through support groups and thorough advice.

• #65 Posterior Cortical Atrophy | Stellar Care

  https://stellarcaresd.com/posterior-cortical-atrophy/

  Currently, there is no cure for Posterior Cortical Atrophy (PCA), and treatment focuses on managing its symptoms and providing support to enhance the individuals quality of life. Some approaches commonly used in the treatment of PCA are: […] Medications may be prescribed to manage specific symptoms of PCA. These can include medications to address visual disturbances, sleep disturbances, depression, or anxiety. […] Occupational therapists can help people with PCA develop strategies to cope with daily tasks affected by visual and cognitive difficulties. These include techniques to improve spatial awareness, organization, and adaptive strategies for activities of daily living. […] Visual aids such as magnifiers, large-print materials, and electronic devices with text-to-speech capabilities can assist individuals with PCA in reading and other visual tasks.

• #66 Posterior Cortical Atrophy | Stellar Care

  https://stellarcaresd.com/posterior-cortical-atrophy/

  Currently, there is no cure for Posterior Cortical Atrophy (PCA), and treatment focuses on managing its symptoms and providing support to enhance the individuals quality of life. Some approaches commonly used in the treatment of PCA are: […] Medications may be prescribed to manage specific symptoms of PCA. These can include medications to address visual disturbances, sleep disturbances, depression, or anxiety. […] Occupational therapists can help people with PCA develop strategies to cope with daily tasks affected by visual and cognitive difficulties. These include techniques to improve spatial awareness, organization, and adaptive strategies for activities of daily living. […] Visual aids such as magnifiers, large-print materials, and electronic devices with text-to-speech capabilities can assist individuals with PCA in reading and other visual tasks.

• #67 Posterior cortical atrophy (PCA) | Dementia Australia

  https://www.dementia.org.au/about-dementia/posterior-cortical-atrophy-pca

  There is no medication to treat posterior cortical atrophy specifically, and there’s no known cure yet. […] Your doctor may prescribe medications used to treat Alzheimers disease. They can treat the symptoms of PCA, and they may slow its progression. […] Psychological therapies or antidepressant medication may be used to improve low mood, depression, irritability, frustration and loss of self-confidence. […] Visual aids can help you with visual impairment. You can try talking clocks or watches, mobile phones with simplified displays, cooking aids such as sensors that beep when a cup is almost full and audio books. […] Occupational therapy can help people find ways to adapt to changes in abilities and maintain independence and wellbeing.

• #68 Posterior cortical atrophy (PCA) | Dementia Australia

  https://www.dementia.org.au/about-dementia/posterior-cortical-atrophy-pca

  There is no medication to treat posterior cortical atrophy specifically, and there’s no known cure yet. […] Your doctor may prescribe medications used to treat Alzheimers disease. They can treat the symptoms of PCA, and they may slow its progression. […] Psychological therapies or antidepressant medication may be used to improve low mood, depression, irritability, frustration and loss of self-confidence. […] Visual aids can help you with visual impairment. You can try talking clocks or watches, mobile phones with simplified displays, cooking aids such as sensors that beep when a cup is almost full and audio books. […] Occupational therapy can help people find ways to adapt to changes in abilities and maintain independence and wellbeing.

• #69 Posterior cortical atrophy (PCA) | Dementia Australia

  https://www.dementia.org.au/about-dementia/posterior-cortical-atrophy-pca

  There is no medication to treat posterior cortical atrophy specifically, and there’s no known cure yet. […] Your doctor may prescribe medications used to treat Alzheimers disease. They can treat the symptoms of PCA, and they may slow its progression. […] Psychological therapies or antidepressant medication may be used to improve low mood, depression, irritability, frustration and loss of self-confidence. […] Visual aids can help you with visual impairment. You can try talking clocks or watches, mobile phones with simplified displays, cooking aids such as sensors that beep when a cup is almost full and audio books. […] Occupational therapy can help people find ways to adapt to changes in abilities and maintain independence and wellbeing.

• #70 Posterior cortical atrophy: a dementia that affects the vision — DPUK

  https://www.dementiasplatform.uk/news-and-media/blog/posterior-cortical-atrophy-a-dementia-that-affects-the-vision

  Currently, we do not know why people develop PCA or what risk factors there are for it. There is also no medication that specifically treats PCA, although some people find that drugs designed for Alzheimers disease or Parkinsons help their symptoms. […] The charity Rare Dementia Support recommends people with PCA try visual aids like sensors that inform the user when a cup is full, talking clocks, and technology with big buttons and a simple display. Controlling light levels by switching lights on before it gets dark and using lampshades to soften harsh lights can also help people with PCA to understand their surroundings better. Rare Dementia Support also provides support for people diagnosed with PCA through support groups and thorough advice.

• #71 Posterior Cortical Atrophy | Treatment & Management | Point of Care

  https://www.statpearls.com/point-of-care/132241

  Pharmacological management: Data on anticholinesterase inhibitors in PCA is lacking. However, since the majority of the cases of PCA are secondary to underlying AD pathology, targeting the underlying pathophysiology using anticholinesterase inhibitors and memantine is an appropriate choice. There are individual case reports that describe the responsiveness of PCA to anticholinesterase inhibitors.[23] (B3) […] As the visual impairment progresses with preservation of insight and the emergence of increasing dependence, patients commonly deal with significant feelings of overwhelming anxiety and depression.[24] Patients may benefit from selective serotonin reuptake inhibitors (SSRIs) to cope with anxiety and mood changes. […] Non-pharmacological management: The mainstay of the treatment approach is non-pharmacological, with interventions geared toward providing more coping strategies, psychological support, and care.[17] The goal would be to compensate at least partially for deficits with improved daily functioning, everyday skills, self-care, and quality of life.[25] (B3) […] It is of paramount importance that an early diagnosis is made so that safety measures are implemented on time, such as ensuring safety by avoiding driving, removing unsafe furniture, and ensuring safety adaptations to the home settings. Encouraging audiobooks can help compensate for deficits in reading as the disease progresses. […] Use of voice recognition, smartphone apps, labeling around doorknobs and hallways, home adaptions in the kitchen, bathroom, and staircase can help compensate for the visuospatial deficits and navigate everyday living. In addition, referring patients and families to support groups for PCA can immensely benefit.

• #72 Posterior Cortical Atrophy – MD Searchlight

  https://mdsearchlight.com/neurology/posterior-cortical-atrophy/

  Beyond medication, there are lots of ways to support PCA patients. These methods aim to help them function better each day, improve their daily skills, take care of themselves, and enhance their overall quality of life. Medical professionals often recommend strategies to help patients cope, psychological support, and specialized care. […] Getting an early diagnosis is very important because it means patients can start implementing safety measures earlier on. For example, they might need to stop driving or change their home environment by removing any potentially hazardous furniture and making safety adjustments. […] To make up for reading difficulties as the disease progresses, patients might find it helpful to engage with audiobooks. Technologies such as voice recognition and smartphone apps, as well as labels on doorknobs and pathways, can be useful for handling visual and spatial challenges. Adapting the home environment, especially the kitchen, bathroom, and stairs, can also improve their ability to manage daily life. […] Finally, connecting patients and their families with support groups specifically for PCA can provide significant benefits. Its critical for them to know theyre not alone, and they can find tremendous comfort and advice from those who understand what theyre going through.

• #73 Posterior Cortical Atrophy – MD Searchlight

  https://mdsearchlight.com/neurology/posterior-cortical-atrophy/

  Beyond medication, there are lots of ways to support PCA patients. These methods aim to help them function better each day, improve their daily skills, take care of themselves, and enhance their overall quality of life. Medical professionals often recommend strategies to help patients cope, psychological support, and specialized care. […] Getting an early diagnosis is very important because it means patients can start implementing safety measures earlier on. For example, they might need to stop driving or change their home environment by removing any potentially hazardous furniture and making safety adjustments. […] To make up for reading difficulties as the disease progresses, patients might find it helpful to engage with audiobooks. Technologies such as voice recognition and smartphone apps, as well as labels on doorknobs and pathways, can be useful for handling visual and spatial challenges. Adapting the home environment, especially the kitchen, bathroom, and stairs, can also improve their ability to manage daily life. […] Finally, connecting patients and their families with support groups specifically for PCA can provide significant benefits. Its critical for them to know theyre not alone, and they can find tremendous comfort and advice from those who understand what theyre going through.

• #74 Posterior Cortical Atrophy – MD Searchlight

  https://mdsearchlight.com/neurology/posterior-cortical-atrophy/

  Beyond medication, there are lots of ways to support PCA patients. These methods aim to help them function better each day, improve their daily skills, take care of themselves, and enhance their overall quality of life. Medical professionals often recommend strategies to help patients cope, psychological support, and specialized care. […] Getting an early diagnosis is very important because it means patients can start implementing safety measures earlier on. For example, they might need to stop driving or change their home environment by removing any potentially hazardous furniture and making safety adjustments. […] To make up for reading difficulties as the disease progresses, patients might find it helpful to engage with audiobooks. Technologies such as voice recognition and smartphone apps, as well as labels on doorknobs and pathways, can be useful for handling visual and spatial challenges. Adapting the home environment, especially the kitchen, bathroom, and stairs, can also improve their ability to manage daily life. […] Finally, connecting patients and their families with support groups specifically for PCA can provide significant benefits. Its critical for them to know theyre not alone, and they can find tremendous comfort and advice from those who understand what theyre going through.

• #75

  https://www.brain.northwestern.edu/dementia/pca/care-treatment.html

  Though there is no cure for this syndrome, some medications and lifestyle modifications are available. […] If Alzheimers or Lewy Body Disease is causing the syndrome of PCA an acetylcholinesterase inhibitor (most commonly: donepezil) is used to slow the course of the disease. In the case of Alzheimers Disease, memantine is often added later on. […] Frequent exercise and diets rich in plants are beneficial as well. […] Patients and families should may work with an occupational therapist to develop compensation strategies tailored to each patients individual deficits. […] In general, patients benefit from reduced clutter around the house, non-visual cues, and greater supervision with demanding or potentially dangerous tasks such as cooking. […] Each patient with PCA should talk with their doctor to determine if they are safe to drive. […] Social workers also provide essential support to patients and families throughout the course of the disease.

• #76

  https://www.brain.northwestern.edu/dementia/pca/care-treatment.html

  Though there is no cure for this syndrome, some medications and lifestyle modifications are available. […] If Alzheimers or Lewy Body Disease is causing the syndrome of PCA an acetylcholinesterase inhibitor (most commonly: donepezil) is used to slow the course of the disease. In the case of Alzheimers Disease, memantine is often added later on. […] Frequent exercise and diets rich in plants are beneficial as well. […] Patients and families should may work with an occupational therapist to develop compensation strategies tailored to each patients individual deficits. […] In general, patients benefit from reduced clutter around the house, non-visual cues, and greater supervision with demanding or potentially dangerous tasks such as cooking. […] Each patient with PCA should talk with their doctor to determine if they are safe to drive. […] Social workers also provide essential support to patients and families throughout the course of the disease.

• #77

  https://www.brain.northwestern.edu/dementia/pca/care-treatment.html

  Though there is no cure for this syndrome, some medications and lifestyle modifications are available. […] If Alzheimers or Lewy Body Disease is causing the syndrome of PCA an acetylcholinesterase inhibitor (most commonly: donepezil) is used to slow the course of the disease. In the case of Alzheimers Disease, memantine is often added later on. […] Frequent exercise and diets rich in plants are beneficial as well. […] Patients and families should may work with an occupational therapist to develop compensation strategies tailored to each patients individual deficits. […] In general, patients benefit from reduced clutter around the house, non-visual cues, and greater supervision with demanding or potentially dangerous tasks such as cooking. […] Each patient with PCA should talk with their doctor to determine if they are safe to drive. […] Social workers also provide essential support to patients and families throughout the course of the disease.

• #78 Posterior Cortical Atrophy: Overview of Causes and Management

  https://www.medicoverhospitals.in/diseases/posterior-cortical-atrophy/

  Currently, there is no cure for PCA, and treatment focuses on managing symptoms and improving quality of life. Interventions may include: […] Pharmacological Treatments […] Cholinesterase inhibitors: Medications commonly used in Alzheimers disease may help improve cognitive symptoms. […] Antidepressants and anxiolytics: These can be prescribed to address mood and anxiety disorders often associated with PCA. […] Supportive Therapies […] Occupational therapy: Assists in adapting daily activities to accommodate visual and cognitive challenges. […] Visual aids and strategies: Implementing tools and techniques to enhance visual perception and navigation. […] Lifestyle Modifications […] Encouraging a healthy lifestyle, including regular physical exercise, a balanced diet, and cognitive stimulation, can support overall brain health and well-being. […] Treatment options focus on managing symptoms and supporting cognitive function.

• #79 Treatment of a patient with posterior cortical atrophy (PCA) with chiropractic manipulation and Dynamic Neuromuscular Stabilization (DNS): A case report

  https://pmc.ncbi.nlm.nih.gov/articles/PMC4319453/

  Posterior cortical atrophy (PCA) is a rare progressive neurodegenerative syndrome which unusual symptoms include deficits of balance, bodily orientation, chronic pain syndrome and dysfunctional motor patterns. Current research provides minimal guidance on support, education and recommended evidence-based patient care. This case reports the utilization of chiropractic spinal manipulation, dynamic neuromuscular stabilization (DNS), and other adjunctive procedures along with medical treatment of PCA. […] Chiropractic spinal manipulation and dynamic neuromuscular stabilization were utilized as adjunctive care to conservative pharmacological treatment of PCA. Outcome measurements showed a 60% improvement in the patients perception of health with restored functional neuromuscular pattern, improvements in locomotion, posture, pain control, mood, tolerance to activities of daily living (ADLs) and overall satisfactory progress in quality of life. Yet, no changes on memory loss progression, visual space orientation, and speech were observed.

• #80 Unlocking Hope for Neurodegenerative Conditions Using Holistic Approaches – Rocket City Chiropractic

  https://www.rocketcitychiropractic.com/unlocking-hope-for-neurodegenerative-conditions-using-holistic-approaches/

  Chiropractic care, with its holistic approach to healthcare, holds potential as a treatment option for neurodegenerative diseases. […] Chiropractic care recognizes the role of the nervous system in regulating bodily functions and communication. Neurodegenerative diseases involve disruptions in neurological function, and chiropractors aim to address these underlying dysfunctions. […] Chiropractic care seeks to optimize nervous system function by removing interference along the spine, known as subluxations. […] Chiropractic care aims to improve this communication by optimizing spinal function. […] Chiropractic care can potentially play a role in treating neurodegenerative diseases. […] By realigning the spine, chiropractic adjustments can potentially relieve pressure on the nerves and enhance nervous system function.

• #81 Treatment of a patient with posterior cortical atrophy (PCA) with chiropractic manipulation and Dynamic Neuromuscular Stabilization (DNS): A case report

  https://pmc.ncbi.nlm.nih.gov/articles/PMC4319453/

  Adjunctive rehabilitative treatment is considered essential for individuals with cognitive and motor disturbances, and manual medicine procedures may be consider a viable option. […] Additional efforts must be centered on the musculoskeletal features of PCA, aiming enhancement in quality of life and functional improvements (FI). […] Dynamic Neuromuscular Stabilization may be considered an adjunctive therapy in such cases to help enhance specific functions of the musculoskeletal system. […] Chiropractic, DNS, and adjunctive therapies can help manage neuro-muscular compensations and altered movement patterns, secondary to improper spinal mechanics, and dysfunctional sensory inputs between muscle groups focusing in enhancing structural mobility, postural integrity and enhance neuromuscular function.

• #82 Treatment of a patient with posterior cortical atrophy (PCA) with chiropractic manipulation and Dynamic Neuromuscular Stabilization (DNS): A case report

  https://pmc.ncbi.nlm.nih.gov/articles/PMC4319453/

  Adjunctive rehabilitative treatment is considered essential for individuals with cognitive and motor disturbances, and manual medicine procedures may be consider a viable option. […] Additional efforts must be centered on the musculoskeletal features of PCA, aiming enhancement in quality of life and functional improvements (FI). […] Dynamic Neuromuscular Stabilization may be considered an adjunctive therapy in such cases to help enhance specific functions of the musculoskeletal system. […] Chiropractic, DNS, and adjunctive therapies can help manage neuro-muscular compensations and altered movement patterns, secondary to improper spinal mechanics, and dysfunctional sensory inputs between muscle groups focusing in enhancing structural mobility, postural integrity and enhance neuromuscular function.

• #83 Treatment of a patient with posterior cortical atrophy (PCA) with chiropractic manipulation and Dynamic Neuromuscular Stabilization (DNS): A case report

  https://pmc.ncbi.nlm.nih.gov/articles/PMC4319453/

  Posterior cortical atrophy (PCA) is a rare progressive neurodegenerative syndrome which unusual symptoms include deficits of balance, bodily orientation, chronic pain syndrome and dysfunctional motor patterns. Current research provides minimal guidance on support, education and recommended evidence-based patient care. This case reports the utilization of chiropractic spinal manipulation, dynamic neuromuscular stabilization (DNS), and other adjunctive procedures along with medical treatment of PCA. […] Chiropractic spinal manipulation and dynamic neuromuscular stabilization were utilized as adjunctive care to conservative pharmacological treatment of PCA. Outcome measurements showed a 60% improvement in the patients perception of health with restored functional neuromuscular pattern, improvements in locomotion, posture, pain control, mood, tolerance to activities of daily living (ADLs) and overall satisfactory progress in quality of life. Yet, no changes on memory loss progression, visual space orientation, and speech were observed.

• #84 Treatment of a patient with posterior cortical atrophy (PCA) with chiropractic manipulation and Dynamic Neuromuscular Stabilization (DNS): A case report

  https://pmc.ncbi.nlm.nih.gov/articles/PMC4319453/

  Posterior cortical atrophy (PCA) is a rare progressive neurodegenerative syndrome which unusual symptoms include deficits of balance, bodily orientation, chronic pain syndrome and dysfunctional motor patterns. Current research provides minimal guidance on support, education and recommended evidence-based patient care. This case reports the utilization of chiropractic spinal manipulation, dynamic neuromuscular stabilization (DNS), and other adjunctive procedures along with medical treatment of PCA. […] Chiropractic spinal manipulation and dynamic neuromuscular stabilization were utilized as adjunctive care to conservative pharmacological treatment of PCA. Outcome measurements showed a 60% improvement in the patients perception of health with restored functional neuromuscular pattern, improvements in locomotion, posture, pain control, mood, tolerance to activities of daily living (ADLs) and overall satisfactory progress in quality of life. Yet, no changes on memory loss progression, visual space orientation, and speech were observed.

• #85 Physical medicine and rehabilitation multidisciplinary approach in a case of posterior cortical atrophy | Musculoskeletal Key

  https://musculoskeletalkey.com/physical-medicine-and-rehabilitation-multidisciplinary-approach-in-a-case-of-posterior-cortical-atrophy/

  Posterior cortical atrophy (PCA) is a degenerative syndrome heralded by progressive visual and spatial disorders, while the memory and execution capacities remain preserved for a long time. […] Our objective is to highlight the interest of a multidisciplinary approach in PCA. […] A six-month multidisciplinary approach (speech therapy, occupational therapy, and physiotherapy) centered on her visual disturbances and associated to the reinforcement of her preserved abilities, as well as a rehabilitation program, was proposed. […] The specific therapeutic management allowed reaching functional objectives. […] The neurodegenerative pathologies responsible for specific instrumental disabilities without global cognitive alteration, and particularly PCA, should be able to benefit from a specific, or even multidisciplinary PMR therapy approach.

• #86 Physical medicine and rehabilitation multidisciplinary approach in a case of posterior cortical atrophy | Musculoskeletal Key

  https://musculoskeletalkey.com/physical-medicine-and-rehabilitation-multidisciplinary-approach-in-a-case-of-posterior-cortical-atrophy/

  Posterior cortical atrophy (PCA) is a degenerative syndrome heralded by progressive visual and spatial disorders, while the memory and execution capacities remain preserved for a long time. […] Our objective is to highlight the interest of a multidisciplinary approach in PCA. […] A six-month multidisciplinary approach (speech therapy, occupational therapy, and physiotherapy) centered on her visual disturbances and associated to the reinforcement of her preserved abilities, as well as a rehabilitation program, was proposed. […] The specific therapeutic management allowed reaching functional objectives. […] The neurodegenerative pathologies responsible for specific instrumental disabilities without global cognitive alteration, and particularly PCA, should be able to benefit from a specific, or even multidisciplinary PMR therapy approach.

• #87 Physical medicine and rehabilitation multidisciplinary approach in a case of posterior cortical atrophy | Musculoskeletal Key

  https://musculoskeletalkey.com/physical-medicine-and-rehabilitation-multidisciplinary-approach-in-a-case-of-posterior-cortical-atrophy/

  Rehabilitation therapy of these patients is still little documented in literature, although advised, as its benefits for the patients are encouraging. […] The objective of this clinical case study was to underline the interest of a multidisciplinary approach (speech therapy, occupational therapy, and physiotherapy) in PMR in PCA on the visual performances and on quality of life. […] Our hypothesis was that the absence of more global cognitive deficits, like the preservation of episodic memory and executive skills, was able to contribute to the success of this rehabilitation by allowing LO integrating compensation modes. […] Only few publications in literature report on rehabilitation therapy of neurovisual disorders or of patients with PCA, but they report the interest of such a management.

• #88 Physical medicine and rehabilitation multidisciplinary approach in a case of posterior cortical atrophy | Musculoskeletal Key

  https://musculoskeletalkey.com/physical-medicine-and-rehabilitation-multidisciplinary-approach-in-a-case-of-posterior-cortical-atrophy/

  Posterior cortical atrophy (PCA) is a degenerative syndrome heralded by progressive visual and spatial disorders, while the memory and execution capacities remain preserved for a long time. […] Our objective is to highlight the interest of a multidisciplinary approach in PCA. […] A six-month multidisciplinary approach (speech therapy, occupational therapy, and physiotherapy) centered on her visual disturbances and associated to the reinforcement of her preserved abilities, as well as a rehabilitation program, was proposed. […] The specific therapeutic management allowed reaching functional objectives. […] The neurodegenerative pathologies responsible for specific instrumental disabilities without global cognitive alteration, and particularly PCA, should be able to benefit from a specific, or even multidisciplinary PMR therapy approach.

• #89 Physical medicine and rehabilitation multidisciplinary approach in a case of posterior cortical atrophy | Musculoskeletal Key

  https://musculoskeletalkey.com/physical-medicine-and-rehabilitation-multidisciplinary-approach-in-a-case-of-posterior-cortical-atrophy/

  Rehabilitation therapy of these patients is still little documented in literature, although advised, as its benefits for the patients are encouraging. […] The objective of this clinical case study was to underline the interest of a multidisciplinary approach (speech therapy, occupational therapy, and physiotherapy) in PMR in PCA on the visual performances and on quality of life. […] Our hypothesis was that the absence of more global cognitive deficits, like the preservation of episodic memory and executive skills, was able to contribute to the success of this rehabilitation by allowing LO integrating compensation modes. […] Only few publications in literature report on rehabilitation therapy of neurovisual disorders or of patients with PCA, but they report the interest of such a management.

• #90 Physical medicine and rehabilitation multidisciplinary approach in a case of posterior cortical atrophy | Musculoskeletal Key

  https://musculoskeletalkey.com/physical-medicine-and-rehabilitation-multidisciplinary-approach-in-a-case-of-posterior-cortical-atrophy/

  The specific management of LO has allowed reaching functional objectives responding to particular and focused requests of the patient. […] This study describes a multidisciplinary management in PMR of a patient with PCA without deficit of the executive functions. The specific therapeutic management allowed reaching the functional objectives responding to the patients request and has shown benefits in daily life.

• #91 Posterior Cortical Atrophy | Treatment & Management | Point of Care

  https://www.statpearls.com/point-of-care/132241

  Pharmacological management: Data on anticholinesterase inhibitors in PCA is lacking. However, since the majority of the cases of PCA are secondary to underlying AD pathology, targeting the underlying pathophysiology using anticholinesterase inhibitors and memantine is an appropriate choice. There are individual case reports that describe the responsiveness of PCA to anticholinesterase inhibitors.[23] (B3) […] As the visual impairment progresses with preservation of insight and the emergence of increasing dependence, patients commonly deal with significant feelings of overwhelming anxiety and depression.[24] Patients may benefit from selective serotonin reuptake inhibitors (SSRIs) to cope with anxiety and mood changes. […] Non-pharmacological management: The mainstay of the treatment approach is non-pharmacological, with interventions geared toward providing more coping strategies, psychological support, and care.[17] The goal would be to compensate at least partially for deficits with improved daily functioning, everyday skills, self-care, and quality of life.[25] (B3) […] It is of paramount importance that an early diagnosis is made so that safety measures are implemented on time, such as ensuring safety by avoiding driving, removing unsafe furniture, and ensuring safety adaptations to the home settings. Encouraging audiobooks can help compensate for deficits in reading as the disease progresses. […] Use of voice recognition, smartphone apps, labeling around doorknobs and hallways, home adaptions in the kitchen, bathroom, and staircase can help compensate for the visuospatial deficits and navigate everyday living. In addition, referring patients and families to support groups for PCA can immensely benefit.

• #92

  https://www.brain.northwestern.edu/dementia/pca/care-treatment.html

  Though there is no cure for this syndrome, some medications and lifestyle modifications are available. […] If Alzheimers or Lewy Body Disease is causing the syndrome of PCA an acetylcholinesterase inhibitor (most commonly: donepezil) is used to slow the course of the disease. In the case of Alzheimers Disease, memantine is often added later on. […] Frequent exercise and diets rich in plants are beneficial as well. […] Patients and families should may work with an occupational therapist to develop compensation strategies tailored to each patients individual deficits. […] In general, patients benefit from reduced clutter around the house, non-visual cues, and greater supervision with demanding or potentially dangerous tasks such as cooking. […] Each patient with PCA should talk with their doctor to determine if they are safe to drive. […] Social workers also provide essential support to patients and families throughout the course of the disease.

• #93 Posterior Cortical Atrophy | Treatment & Management | Point of Care

  https://www.statpearls.com/point-of-care/132241

  Pharmacological management: Data on anticholinesterase inhibitors in PCA is lacking. However, since the majority of the cases of PCA are secondary to underlying AD pathology, targeting the underlying pathophysiology using anticholinesterase inhibitors and memantine is an appropriate choice. There are individual case reports that describe the responsiveness of PCA to anticholinesterase inhibitors.[23] (B3) […] As the visual impairment progresses with preservation of insight and the emergence of increasing dependence, patients commonly deal with significant feelings of overwhelming anxiety and depression.[24] Patients may benefit from selective serotonin reuptake inhibitors (SSRIs) to cope with anxiety and mood changes. […] Non-pharmacological management: The mainstay of the treatment approach is non-pharmacological, with interventions geared toward providing more coping strategies, psychological support, and care.[17] The goal would be to compensate at least partially for deficits with improved daily functioning, everyday skills, self-care, and quality of life.[25] (B3) […] It is of paramount importance that an early diagnosis is made so that safety measures are implemented on time, such as ensuring safety by avoiding driving, removing unsafe furniture, and ensuring safety adaptations to the home settings. Encouraging audiobooks can help compensate for deficits in reading as the disease progresses. […] Use of voice recognition, smartphone apps, labeling around doorknobs and hallways, home adaptions in the kitchen, bathroom, and staircase can help compensate for the visuospatial deficits and navigate everyday living. In addition, referring patients and families to support groups for PCA can immensely benefit.

• #94 Posterior Cortical Atrophy | Treatment & Management | Point of Care

  https://www.statpearls.com/point-of-care/132241

  Pharmacological management: Data on anticholinesterase inhibitors in PCA is lacking. However, since the majority of the cases of PCA are secondary to underlying AD pathology, targeting the underlying pathophysiology using anticholinesterase inhibitors and memantine is an appropriate choice. There are individual case reports that describe the responsiveness of PCA to anticholinesterase inhibitors.[23] (B3) […] As the visual impairment progresses with preservation of insight and the emergence of increasing dependence, patients commonly deal with significant feelings of overwhelming anxiety and depression.[24] Patients may benefit from selective serotonin reuptake inhibitors (SSRIs) to cope with anxiety and mood changes. […] Non-pharmacological management: The mainstay of the treatment approach is non-pharmacological, with interventions geared toward providing more coping strategies, psychological support, and care.[17] The goal would be to compensate at least partially for deficits with improved daily functioning, everyday skills, self-care, and quality of life.[25] (B3) […] It is of paramount importance that an early diagnosis is made so that safety measures are implemented on time, such as ensuring safety by avoiding driving, removing unsafe furniture, and ensuring safety adaptations to the home settings. Encouraging audiobooks can help compensate for deficits in reading as the disease progresses. […] Use of voice recognition, smartphone apps, labeling around doorknobs and hallways, home adaptions in the kitchen, bathroom, and staircase can help compensate for the visuospatial deficits and navigate everyday living. In addition, referring patients and families to support groups for PCA can immensely benefit.

• #95 Posterior Cortical Atrophy | Treatment & Management | Point of Care

  https://www.statpearls.com/point-of-care/132241

  Pharmacological management: Data on anticholinesterase inhibitors in PCA is lacking. However, since the majority of the cases of PCA are secondary to underlying AD pathology, targeting the underlying pathophysiology using anticholinesterase inhibitors and memantine is an appropriate choice. There are individual case reports that describe the responsiveness of PCA to anticholinesterase inhibitors.[23] (B3) […] As the visual impairment progresses with preservation of insight and the emergence of increasing dependence, patients commonly deal with significant feelings of overwhelming anxiety and depression.[24] Patients may benefit from selective serotonin reuptake inhibitors (SSRIs) to cope with anxiety and mood changes. […] Non-pharmacological management: The mainstay of the treatment approach is non-pharmacological, with interventions geared toward providing more coping strategies, psychological support, and care.[17] The goal would be to compensate at least partially for deficits with improved daily functioning, everyday skills, self-care, and quality of life.[25] (B3) […] It is of paramount importance that an early diagnosis is made so that safety measures are implemented on time, such as ensuring safety by avoiding driving, removing unsafe furniture, and ensuring safety adaptations to the home settings. Encouraging audiobooks can help compensate for deficits in reading as the disease progresses. […] Use of voice recognition, smartphone apps, labeling around doorknobs and hallways, home adaptions in the kitchen, bathroom, and staircase can help compensate for the visuospatial deficits and navigate everyday living. In addition, referring patients and families to support groups for PCA can immensely benefit.

• #96

  https://www.brain.northwestern.edu/dementia/pca/care-treatment.html

  Though there is no cure for this syndrome, some medications and lifestyle modifications are available. […] If Alzheimers or Lewy Body Disease is causing the syndrome of PCA an acetylcholinesterase inhibitor (most commonly: donepezil) is used to slow the course of the disease. In the case of Alzheimers Disease, memantine is often added later on. […] Frequent exercise and diets rich in plants are beneficial as well. […] Patients and families should may work with an occupational therapist to develop compensation strategies tailored to each patients individual deficits. […] In general, patients benefit from reduced clutter around the house, non-visual cues, and greater supervision with demanding or potentially dangerous tasks such as cooking. […] Each patient with PCA should talk with their doctor to determine if they are safe to drive. […] Social workers also provide essential support to patients and families throughout the course of the disease.

• #97 Posterior Cortical Atrophy | Stellar Care

  https://stellarcaresd.com/posterior-cortical-atrophy/

  People with PCA and their caregivers may benefit from counseling or support groups which provide emotional support, education, and strategies for coping with the challenges posed by PCA. […] Modifying the home environment by reducing clutter, improving lighting, and using contrasting colors can help people with PCA navigate their surroundings safely and effectively. […] As cognitive functions decline, memory aids like calendars, reminder apps, and notes can help people with PCA manage daily schedules and tasks. […] Frequent check-ups with healthcare professionals are essential to monitor the progression of PCA and adjust treatment and support strategies accordingly. […] An individual care plan should be developed to meet the specific needs and symptoms of each person with PCA. Close collaboration with neurologists, ophthalmologists, and occupational therapists, is important for managing PCA.

• #98 Posterior Cortical Atrophy | Stellar Care

  https://stellarcaresd.com/posterior-cortical-atrophy/

  People with PCA and their caregivers may benefit from counseling or support groups which provide emotional support, education, and strategies for coping with the challenges posed by PCA. […] Modifying the home environment by reducing clutter, improving lighting, and using contrasting colors can help people with PCA navigate their surroundings safely and effectively. […] As cognitive functions decline, memory aids like calendars, reminder apps, and notes can help people with PCA manage daily schedules and tasks. […] Frequent check-ups with healthcare professionals are essential to monitor the progression of PCA and adjust treatment and support strategies accordingly. […] An individual care plan should be developed to meet the specific needs and symptoms of each person with PCA. Close collaboration with neurologists, ophthalmologists, and occupational therapists, is important for managing PCA.

• #99 Azthena logo with the word Azthena

  https://www.news-medical.net/news/20240122/Posterior-cortical-atrophy-predicts-Alzheimers-study-finds.aspx

  We need better tools and training to identify patients […] Early identification of PCA may have important implications for Alzheimer’s treatment, said co-first author Renaud La Joie, Ph.D., also of the UCSF Department of Neurology and the Memory and Aging Center. In the study, levels of amyloid and tau, identified in cerebrospinal fluid and imaging, as well as autopsy data, matched those found in typical Alzheimer’s cases. As a result, patients with PCA may be candidates for anti-amyloid therapies, like lecanemab (Leqembi), approved by the U.S Food and Drug Administration in January 2023, and anti-tau therapies, currently in clinical trials, both of which are believed to be more effective in the earliest phases of the disease, he said. […] Patients have mostly been excluded from trials, since they are „usually aimed at patients with amnestic Alzheimer’s with low scores on memory tests,” La Joie added. „However, at UCSF we are considering treatments for patients with PCA and other non-amnestic variants.”

• #100 Posterior Cortical Atrophy: One 53-year-old’s Journey to Diagnosis | Being Patient

  https://www.beingpatient.com/posterior-cortical-atrophy-deb-jobe/

  Deb Jobe refused to let an early diagnosis of posterior cortical atrophy keep her from living a fulfilling, joyous life. […] I was very fortunate in my path of diagnosis, and I’m so passionate about early intervention and about getting to the doctor. […] Number one is counseling. They put me in counseling right away to come to terms with what was happening. […] The counseling helped. The support groups know you’re not alone. […] If just one person takes my advice and gets their loved one, their family member, a friend, any concern, get it checked out. […] There is so much that can be done and there is so much innovation now happening with therapies and drugs. […] Counseling, the referral to cognitive therapy, and getting local support are the top things that you absolutely should do. […] Please don’t stop doing them because that’s what brings you joy. […] Whatever your passion is, do it. Don’t waste time. […] I believe that this is what is helping me continue to live. […] Don’t lose your faith.

• #101 Azthena logo with the word Azthena

  https://www.news-medical.net/news/20240122/Posterior-cortical-atrophy-predicts-Alzheimers-study-finds.aspx

  We need better tools and training to identify patients […] Early identification of PCA may have important implications for Alzheimer’s treatment, said co-first author Renaud La Joie, Ph.D., also of the UCSF Department of Neurology and the Memory and Aging Center. In the study, levels of amyloid and tau, identified in cerebrospinal fluid and imaging, as well as autopsy data, matched those found in typical Alzheimer’s cases. As a result, patients with PCA may be candidates for anti-amyloid therapies, like lecanemab (Leqembi), approved by the U.S Food and Drug Administration in January 2023, and anti-tau therapies, currently in clinical trials, both of which are believed to be more effective in the earliest phases of the disease, he said. […] Patients have mostly been excluded from trials, since they are „usually aimed at patients with amnestic Alzheimer’s with low scores on memory tests,” La Joie added. „However, at UCSF we are considering treatments for patients with PCA and other non-amnestic variants.”

• #102 Posterior Cortical Atrophy (PCA)

  https://ftdboston.org/diagnosis/posterior-cortical-atrophy/

  The MGH FTD Units PCA program, under the direction of Deepti Putcha, Ph.D., offers a cross-discipline collaborative approach to caring for people living with PCA as well as for their families. Our patients will receive a highly specialized clinical evaluation, which can diagnose or provide a second opinion confirmation of the PCA diagnosis. […] We also facilitate referrals to appropriate specialists and resources designed to optimize quality of life in line with evidence-based treatment guidelines. […] We also work with the MA Association for the Blind to secure services and accommodations that our patients may benefit from. […] Our team is conducting several ongoing research studies aimed at better understanding the clinical, cognitive, and neurological features of PCA. […] Participants will have the opportunity to access educational and support resources to better understand how to live with the diagnosis of PCA. […] Our PCA research and support programs aim to fully understand this rare illness and develop techniques for earlier detection and better care for patients and families.

• #103 Posterior Cortical Atrophy (PCA)

  https://ftdboston.org/diagnosis/posterior-cortical-atrophy/

  The MGH FTD Units PCA program, under the direction of Deepti Putcha, Ph.D., offers a cross-discipline collaborative approach to caring for people living with PCA as well as for their families. Our patients will receive a highly specialized clinical evaluation, which can diagnose or provide a second opinion confirmation of the PCA diagnosis. […] We also facilitate referrals to appropriate specialists and resources designed to optimize quality of life in line with evidence-based treatment guidelines. […] We also work with the MA Association for the Blind to secure services and accommodations that our patients may benefit from. […] Our team is conducting several ongoing research studies aimed at better understanding the clinical, cognitive, and neurological features of PCA. […] Participants will have the opportunity to access educational and support resources to better understand how to live with the diagnosis of PCA. […] Our PCA research and support programs aim to fully understand this rare illness and develop techniques for earlier detection and better care for patients and families.

• #104 Azthena logo with the word Azthena

  https://www.news-medical.net/news/20240122/Posterior-cortical-atrophy-predicts-Alzheimers-study-finds.aspx

  We need better tools and training to identify patients […] Early identification of PCA may have important implications for Alzheimer’s treatment, said co-first author Renaud La Joie, Ph.D., also of the UCSF Department of Neurology and the Memory and Aging Center. In the study, levels of amyloid and tau, identified in cerebrospinal fluid and imaging, as well as autopsy data, matched those found in typical Alzheimer’s cases. As a result, patients with PCA may be candidates for anti-amyloid therapies, like lecanemab (Leqembi), approved by the U.S Food and Drug Administration in January 2023, and anti-tau therapies, currently in clinical trials, both of which are believed to be more effective in the earliest phases of the disease, he said. […] Patients have mostly been excluded from trials, since they are „usually aimed at patients with amnestic Alzheimer’s with low scores on memory tests,” La Joie added. „However, at UCSF we are considering treatments for patients with PCA and other non-amnestic variants.”

• #105 Posterior Cortical Atrophy (PCA)

  https://ftdboston.org/diagnosis/posterior-cortical-atrophy/

  The MGH FTD Units PCA program, under the direction of Deepti Putcha, Ph.D., offers a cross-discipline collaborative approach to caring for people living with PCA as well as for their families. Our patients will receive a highly specialized clinical evaluation, which can diagnose or provide a second opinion confirmation of the PCA diagnosis. […] We also facilitate referrals to appropriate specialists and resources designed to optimize quality of life in line with evidence-based treatment guidelines. […] We also work with the MA Association for the Blind to secure services and accommodations that our patients may benefit from. […] Our team is conducting several ongoing research studies aimed at better understanding the clinical, cognitive, and neurological features of PCA. […] Participants will have the opportunity to access educational and support resources to better understand how to live with the diagnosis of PCA. […] Our PCA research and support programs aim to fully understand this rare illness and develop techniques for earlier detection and better care for patients and families.

• #106 Azthena logo with the word Azthena

  https://www.news-medical.net/news/20240122/Posterior-cortical-atrophy-predicts-Alzheimers-study-finds.aspx

  We need better tools and training to identify patients […] Early identification of PCA may have important implications for Alzheimer’s treatment, said co-first author Renaud La Joie, Ph.D., also of the UCSF Department of Neurology and the Memory and Aging Center. In the study, levels of amyloid and tau, identified in cerebrospinal fluid and imaging, as well as autopsy data, matched those found in typical Alzheimer’s cases. As a result, patients with PCA may be candidates for anti-amyloid therapies, like lecanemab (Leqembi), approved by the U.S Food and Drug Administration in January 2023, and anti-tau therapies, currently in clinical trials, both of which are believed to be more effective in the earliest phases of the disease, he said. […] Patients have mostly been excluded from trials, since they are „usually aimed at patients with amnestic Alzheimer’s with low scores on memory tests,” La Joie added. „However, at UCSF we are considering treatments for patients with PCA and other non-amnestic variants.”

• #107 Azthena logo with the word Azthena

  https://www.news-medical.net/news/20240122/Posterior-cortical-atrophy-predicts-Alzheimers-study-finds.aspx

  We need better tools and training to identify patients […] Early identification of PCA may have important implications for Alzheimer’s treatment, said co-first author Renaud La Joie, Ph.D., also of the UCSF Department of Neurology and the Memory and Aging Center. In the study, levels of amyloid and tau, identified in cerebrospinal fluid and imaging, as well as autopsy data, matched those found in typical Alzheimer’s cases. As a result, patients with PCA may be candidates for anti-amyloid therapies, like lecanemab (Leqembi), approved by the U.S Food and Drug Administration in January 2023, and anti-tau therapies, currently in clinical trials, both of which are believed to be more effective in the earliest phases of the disease, he said. […] Patients have mostly been excluded from trials, since they are „usually aimed at patients with amnestic Alzheimer’s with low scores on memory tests,” La Joie added. „However, at UCSF we are considering treatments for patients with PCA and other non-amnestic variants.”

• #108 Diagnosis and Management of Posterior Cortical Atrophy

  https://pmc.ncbi.nlm.nih.gov/articles/PMC9935654/

  The study aims to provide a summary of recent developments for diagnosing and managing posterior cortical atrophy (PCA). […] Current treatment of PCA is symptomatic pharmacological and non-pharmacological and the use of most treatment options is based on small studies or expert opinion. […] Recommendations for non-pharmacological approaches include interdisciplinary management tailored to the PCA clinical profile visual-spatial rather than memory-led, predominantly young onset and psychosocial implications. […] Currently, management should be tailored to each individual’s symptoms and particular challenges associated with PCA. […] Interdisciplinary management of PCA is key, and may involve a range of professionals across ophthalmology, neurology, psychiatry, allied health and social care disciplines.

• #109 Posterior cortical atrophy | UM Health-Sparrow

  https://www.uofmhealthsparrow.org/departments-conditions/conditions/posterior-cortical-atrophy

  There are no treatments to cure or slow the progression of posterior cortical atrophy. Some research suggests that medicines used to slow the progression of Alzheimer’s disease may help manage symptoms of posterior cortical atrophy. However, this hasn’t been proved, and more research is needed. […] Some therapies and medicines can help manage the condition. They may include: […] Medicines. Your health care provider may give you medicines to treat symptoms such as depression or anxiety. […] Physical, occupational or cognitive therapy. These therapies may help you regain or retain skills that are affected by posterior cortical atrophy.

• #110 Posterior Cortical Atrophy: What It Is, Symptoms & Treatment

  https://my.clevelandclinic.org/health/diseases/posterior-cortical-atrophy

  Healthcare providers cant cure this condition or restore the abilities that youve lost. This may be hard to hear, but there are many things you can do to manage your symptoms, navigate your new way of life and maintain your independence. If you have posterior cortical atrophy, talk to your care team about supportive programs and services. Theyll be glad to help you find the right resources.

• #111 Posterior cortical atrophy – Wikipedia

  https://en.wikipedia.org/wiki/Posterior_cortical_atrophy

  Specific and accepted treatment for PCA has yet to be discovered; this may be due to the rarity and variations of the disease. At times people with PCA are treated with AD treatments, such as cholinesterase inhibitors: donepezil, rivastigmine, galantamine, and also memantine. Antidepressant drugs have also provided some positive effects. […] Other treatments such as occupational therapy, or help with adapting to visual changes may help. Visual and tactile cues, adaptive equipment and digital aids to manipulate text may all be beneficial. People with PCA and their caregivers are likely to have different needs than the more typical cases of Alzheimer’s disease, and may benefit from specialized support groups, or other groups for young people with dementia. No study to date has been definitive to provide accepted conclusive analysis on treatment options.

• #112 Posterior Cortical Atrophy: One 53-year-old’s Journey to Diagnosis | Being Patient

  https://www.beingpatient.com/posterior-cortical-atrophy-deb-jobe/

  Deb Jobe refused to let an early diagnosis of posterior cortical atrophy keep her from living a fulfilling, joyous life. […] I was very fortunate in my path of diagnosis, and I’m so passionate about early intervention and about getting to the doctor. […] Number one is counseling. They put me in counseling right away to come to terms with what was happening. […] The counseling helped. The support groups know you’re not alone. […] If just one person takes my advice and gets their loved one, their family member, a friend, any concern, get it checked out. […] There is so much that can be done and there is so much innovation now happening with therapies and drugs. […] Counseling, the referral to cognitive therapy, and getting local support are the top things that you absolutely should do. […] Please don’t stop doing them because that’s what brings you joy. […] Whatever your passion is, do it. Don’t waste time. […] I believe that this is what is helping me continue to live. […] Don’t lose your faith.

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