Materiały źródłowe

• #1 Acanthosis Nigricans: An Updated Review – PubMed

  https://pubmed.ncbi.nlm.nih.gov/36698243/

  Acanthosis nigricans is characterized by symmetric, hyperpigmented, and velvety plaques with ill-defined borders, typically involving intertriginous areas. […] Obesity is the most common cause of acanthosis nigricans which is increasingly observed in obese children and adolescents and can serve as a cutaneous marker of insulin resistance. […] This may consist of weight reduction, discontinuation of causative drugs, treatment of underlying endocrinopathy, or treatment of an underlying malignancy. […] For patients with isolated acanthosis nigricans and for those whose underlying cause is not amenable to treatment, treatment of the lesion may be considered for cosmetic reasons. […] Although acanthosis nigricans is treatable, a complete cure is difficult to achieve. The underlying cause should be treated, if possible, to resolve and prevent the recurrence of acanthosis nigricans.

• #1 Acanthosis Nigricans: Causes, Diagnosis &Treatment

  https://my.clevelandclinic.org/health/diseases/12168-acanthosis-nigricans

  If obesity is causing AN, you can help prevent the condition through weight management. A diet that helps you keep your blood sugar (insulin) levels in check can also help prevent AN. […] Other preventive steps include: Managing medical conditions related to AN, such as thyroid problems and diabetes. Avoiding medications, such as birth control pills, that can cause or worsen AN.

• #1 Acanthosis Nigricans: Causes, Symptoms, Treatment and Prevention

  https://www.apollohospitals.com/diseases-and-conditions/acanthosis-nigricans-causes-symptoms-treatment-and-prevention

  People must maintain a healthy lifestyle because it can typically prevent acanthosis nigricans. […] They can also: […] Maintain a moderate weight […] Manage their diet […] Adjust any medications that are contributing to the condition.

• #1 Acanthosis nigricans: diagnosis and treatment. Clínica Universidad de Navarra

  https://www.cun.es/en/diseases-treatments/diseases/acanthosis-nigricans

  Prevention of acanthosis nigricans involves controlling associated risk factors, such as maintaining a healthy weight, following a balanced diet, and exercising regularly to prevent insulin resistance. […] Early detection and treatment of underlying disorders can also help prevent the onset of this condition.

• #1 Acanthosis Nigricans – What You Need to Know

  https://www.drugs.com/cg/acanthosis-nigricans.html

  What can I do to manage or prevent AN? […] Reach or maintain a healthy weight. AN skin patches often clear up after weight loss. Your healthcare provider can help you create a safe weight loss plan if you are overweight. […] Eat healthy foods. Healthy foods can help control your blood sugar levels. Examples of healthy foods include fruits, vegetables, whole-grain breads, low-fat dairy products, beans, lean meats, and fish. Your healthcare provider or dietitian can help you create a healthy meal plan. […] Exercise regularly. Exercise can help control your blood sugar level. Exercise can also help you manage your weight or lose weight. Try to get at least 30 minutes of exercise every day on most days of the week, or as directed. […] Use gentle skin care products. Some skin care products can irritate your skin and make AN worse. Ask your healthcare provider which skin care products you should use. He or she may also be able to prescribe or recommend soaps if the patches have an odor.

• #1 Acanthosis nigricans: Appearance, causes, and treatment

  https://www.medicalnewstoday.com/articles/324062

  Acanthosis nigricans does not have a specific cure, but treating the underlying cause can allow it to fade over time. Some topical treatments may also reduce its appearance. […] Treatment for the cause of acanthosis nigricans may involve: Weight management: Maintaining a moderate weight may help improve insulin sensitivity in those with insulin resistance. In turn, skin symptoms may improve. […] Managing blood sugar: People with type 2 diabetes may need medications, monitoring of blood sugar levels, and some dietary and lifestyle adjustments. Once blood sugar levels become stable, acanthosis nigricans symptoms may resolve. […] Balancing hormones: Medication and lifestyle adjustments may help reduce symptoms of acanthosis nigricans in those with hormonal conditions such as PCOS. […] Treatment for malignant acanthosis nigricans includes surgical removal of a cancerous tumor. Other treatments a person may need include chemotherapy and radiation therapy. […] Treating an underlying condition may improve skin symptoms. Some topical and cosmetic treatments may also help.

• #1 Black Neck Solutions: Acanthosis Nigricans Treatment Guide

  https://evaskinclinicpune.com/blogs/acanthosis-nigricans-treatment/

  Essential Preventive Tips: […] Losing weight is related to obesity. […] Replace refined carbohydrates with whole-grain foods. […] Consume foods rich in fiber such as fresh fruits vegetables. […] Minimize snacking on foods with high saturated fats like samosas, pastries, chips biscuits. […] Drink low-fat milk or skim milk instead of whole milk. On similar lines, wheat bread instead of milk bread. […] Eat low-fat meals. […] Drinks plenty of water. […] Exercise regularly. […] Manage stress anxiety. […] Treat underlying problems like diabetes, and hypothyroidism. […] Stay away from medications aggravating or worsening the condition.

• #1 Acanthosis Nigricans – Kidshealth | Akron Children’s

  https://www.akronchildrens.org/kidshealth/en/parents/acanthosis.html

  Eating a healthy diet and getting regular physical activity can help lower insulin levels and improve skin appearance. Try these tips: […] Choose whole grains and plenty of fruits and vegetables. […] Offer water or low-fat milk instead of soda, juice, or other sugary drinks. […] Limit highly processed foods, fatty foods, and sugary treats. […] Encourage your child to be physically active every day.

• #1 Acanthosis nigricans in obese patients: Presentations and implications for prevention of atherosclerotic vascular disease

  https://escholarship.org/uc/item/6fj340w2

  Dietary measures are obviously relevant. Increased exercise is also helpful and important. […] Insulin resistance improves quickly in response to improved diet and increased exercise, and may normalize before patients achieve a normal body weight. […] Thus, once patients begin to lose weight, there is the expectation of rapid improvement in the acanthosis nigricans. […] The presence of acanthosis nigricans indicates to both the physician and the patient that there is a serious biochemical disorder that requires intervention. […] Elevated blood insulin levels are helpful for demonstrating to patients the cause of their condition and the need for exercise and dietary interventions.

• #1 Acanthosis Nigricans (AN) | Nationwide Children’s Hospital

  https://www.nationwidechildrens.org/conditions/acanthosis-nigricans

  Acanthosis nigricans is a skin condition characterized by dark, thick, velvety patches of skin in body folds and creases. […] The good news is that taking control over your weight — learning to eat well, being active and losing some weight — lowers the amount of unused insulin in your body. This will help get rid of AN. […] Losing weight will be an important part of your care plan. Here are a few tips you can use: […] The more calories you burn up, the better your body uses insulin. You dont have to start running marathons. But make sure that you do something active every day.

• #1 Acanthosis Nigricans: Key Symptoms and Treatment Options

  https://www.bajajallianz.com/blog/wellness/symptoms-and-treatment-of-acanthosis-nigricans.html

  While not all cases of acanthosis nigricans can be prevented, adopting certain lifestyle changes might lower the risk of developing the condition: […] Maintain a Healthy Weight: Keeping your weight within a moderate range can reduce the risk of insulin resistance and related skin issues. […] Monitor Blood Sugar Levels: Regularly checking your blood glucose can help in the early detection and management of insulin resistance. […] Balanced Diet: Focus on a diet rich in whole foods, low in refined sugars, and balanced in carbohydrates, fats, and proteins. […] Stay Hydrated: Proper hydration supports overall skin health. […] Routine Medical Check-ups: Regular visits to your healthcare provider can help detect underlying health issues that may lead to acanthosis nigricans early.

• #1 Understanding Acanthosis Nigricans | Saint Luke’s Health System

  https://www.saintlukeskc.org/health-library/understanding-acanthosis-nigricans

  Managing the underlying health problem. Some cases of this skin condition will go away if you take care of the health problem that may be causing it. For example, if you are obese, your skin may improve if you lose some weight. People with diabetes may have clearer skin if they keep their blood sugar under control. […] This skin condition can be treated. Treatment options include: […] Using medicines for the skin (topical). Certain creams, lotions, or gels may help lighten up or dry out the skin. […] In some cases, you may have laser therapy to thin or lighten the skin.

• #1 Current treatment options for acanthosis nigricans | CCID

  https://www.dovepress.com/current-treatment-options-for-acanthosis-nigricans-peer-reviewed-fulltext-article-CCID

  Acanthosis nigricans (AN) is a common dermatologic manifestation of systemic disease that is associated with insulin resistance, diabetes mellitus, obesity, internal malignancy, endocrine disorders, and drug reactions. […] Treatment of AN should focus on correction of the underlying disease process. Weight reduction in obesity-related AN may resolve hyperkeratotic lesions, while correction of hyperinsulinemia can reduce the burden of AN lesions. […] While the goal of therapy for AN is to treat the primary cause, cosmetic resolution of AN lesions can be important for patients and their quality of life. […] Current treatment paradigms for AN are shifting to include addressing the cutaneous pathology as well as the underlying disease or drug. Non-medication options include weight loss and exercise to increase insulin sensitivity in insulin-resistant AN.

• #1 Acanthosis Nigricans in Pre-diabetic states | British Journal of Medical Practitioners

  https://www.bjmp.org/content/acanthosis-nigricans-pre-diabetic-states

  When the occurrence of AN is recognised, a prediabetic person has the opportunity to become more alert to their symptoms and to take precautions in the form of diet restrictions and weight loss. […] If too much insulin is the cause of AN, it is relatively easy for the patient to counter it by changing to a healthier diet, taking exercise, and controlling their blood sugar. […] Early recognition of insulin resistance is paramount in the prevention or delay of the onset of diabetes. […] Identification of AN offers an opportunity to advise families about the causes and consequences of the condition. […] Early screening for AN in preadolescent and adolescent people would provide a relatively simple, inexpensive, and non-invasive tool for identifying those young people who have hyperinsulinemia and could benefit from early intervention. […] It is evident that because of the high incidence of DM type 2 among mental health service users, psychiatrists need to become more alert in the diagnosis, management, and prevention of the complications of DM type 2.

• #1 Acanthosis Nigricans Treatment in Delhi, India | Symptoms & Causes

  https://www.blkmaxhospital.com/our-specialities/dermatology/conditions-treatments/acanthosis-nigricans

  If one suspects any hormonal imbalances, consult a doctor who will recommend appropriate tests and treatments. […] Regular medical check-ups for early detection and intervention: […] Regular medical check-ups are essential for early detection of acanthosis nigricans or any other underlying health conditions. […] Visit the dermatologist or primary care physician for routine skin examinations to monitor any changes in the affected areas. […] Early intervention can help prevent the progression of acanthosis nigricans and minimise its impact on one’s overall health.

• #1 Acanthosis Nigricans: Causes, Diagnosis, and Treatment

  https://dermnetnz.org/topics/acanthosis-nigricans

  The mainstay for treatment is to manage the underlying disease. Patient education is also an important component. […] Non-pharmacologic treatment includes lifestyle modifications, such as establishing healthy eating habits and increasing exercise with the aim of improving insulin resistance/glucose metabolism. […] Pharmacologic treatment includes metformin and rosiglitazone, which are used to reduce insulin levels and moderately improve AN. […] Malignant acanthosis nigricans should be addressed with careful workup and management of any underlying malignancy. […] Resolution of drug-induced AN requires identification and withdrawal of the suspected drug(s). […] Syndromic AN may be improved with treatment of the underlying syndrome, such as with the use of oral contraceptives in the setting of polycystic ovarian syndrome.

• #1 Acanthosis Nigricans: Treatment, Pictures, and Causes

  https://www.healthline.com/health/acanthosis-nigricans

  Maintaining a healthy lifestyle can usually prevent acanthosis nigricans, including: […] managing your diet […] adjusting any medications contributing to the condition.

• #1 Acanthosis nigricans – Point Pleasant Beach, Linden and Staten Island, NJ Dermatologist

  https://www.patriciamccormackmd.com/acanthosis-nigricans/

  Studies show that many obese people see the dark patches on their skin clear when they lose a significant amount of weight. […] Maintain a healthy weight. Obesity is the most common cause of AN in adults and children. Studies have found that peoples skin often clears completely with significant weight loss. You can find out what your healthy weight is by calculating your body mass index. […] Find out if you have a medical condition that is causing AN. Diabetes and other medical conditions can cause AN. Doing things that improve the medical condition often help to clear the skin. […] Find out if a medicine you take is causing AN. Some medicines can cause AN. Be sure to tell your dermatologist about all the medicines you take. If medicine is causing your AN, you may be able to switch to another medicine.

• #1 Acanthosis Nigricans

  https://drkothiwalaskineva.com/medical-dermatology/acanthosis-nigricans/

  Acanthosis nigricans may be associated with some internal illness so with help of some investigations all possible association should be ruled out. […] Treatment for underlying factors […] Weight loss […] Treatment of diabetes or insulin resistance if present. […] Avoid medicines which may result in fast weight gain. […] With all treatments it is possible that acanthosis nigricans does not improve but you should adapt some lifestyle modification and minimal treatment so that it doesn’t worsen. […] Don’t rub the affected skin […] Weight control […] Lifestyle modification […] If family history of obesity or acanthosis nigricans present, start lifestyle modification in advance […] At early stage it can be reversed so stick to doctors’ advice for best results.

• #1 Acanthosis Nigricans Treatment Brisbane – Dr Davin Lim

  https://drdavinlim.com/acanthosis-nigricans-treatment/

  AN is complicated, often requires a team of healthcare professionals to effectively manage this condition. […] The biggest traction is reduction of weight (if this is present). Most require pharmacological management, a few can do it with diet. Metformin orally at 1000 to 1500 mg can be considered as adjunctive treatment in those who have high BMI or impaired sugars.

• #1 Current treatment options for acanthosis nigricans | CCID

  https://www.dovepress.com/current-treatment-options-for-acanthosis-nigricans-peer-reviewed-fulltext-article-CCID

  Oral metformin and combinations of other insulin-mediating medications are effective, as they are therapies aimed at resolving the underlying causes contributing to AN. […] For cosmetic treatment, topical retinoids are considered the first-line therapy for insulin-resistant AN by modifying keratinization rate. […] An important consideration when evaluating a patient with AN is the potential for psychological distress. […] While correction of underlying causes remains the mainstay of treatment, it is important to consider cosmetic options to improve patient quality of life that may be affected by the presence of AN lesions.

• #1

  https://link.springer.com/article/10.1007/s00403-023-02605-6

  10% salicylic acid and 10% urea creams are efficacious and safe in the treatment of acanthosis nigricans. […] Both medications improve neck hyperpigmentation associated with acanthosis nigricans in adolescents, in which the 10% salicylic acid and 10% urea cream demonstrate similar efficacy and safety profiles.

• #1 Acanthosis nigricans in the pediatric population: a narrative review of the current approach to management in primary care – Pollock – Pediatric Medicine

  https://pm.amegroups.org/article/view/6555/html

  Acanthosis nigricans (AN) is frequently seen in obese and overweight children and adolescents. […] Early metabolic screening with focus on insulin sensitivity, liver function, lipid panel, and glucose tolerance is recommended. […] A thorough investigation and appropriate screening of children at risk, with a focus on early identification of the dermatologic condition and its associated comorbidities in the primary care setting, and early treatment is recommended to prevent long term consequences and decrease the risk of cardiovascular complications. […] The most effective first line treatment for AN is weight loss, through both dietary modification and physical activity, to improve underlying hyperinsulinemia and dyslipidemia, and in addition to weight and metabolic control, dermatologic treatment may be implemented. […] Appropriate screening, and identifying AN among children who are at risk for developing metabolic syndrome, will allow for earlier implementation of preventive measures to better control metabolic risk factors, decreasing the risk of cardiovascular complications.

• #1 Acanthosis nigricans in obese patients: Presentations and implications for prevention of atherosclerotic vascular disease

  https://escholarship.org/uc/item/6fj340w2

  Acanthosis nigricans is traditionally characterized by hyperpigmented, velvety plaques of body folds. […] The dermatologist has an important role in identifying the subset of obese patients with acanthosis nigricans. […] It is essential for dermatologists to recognize the many presentations of acanthosis nigricans to identify patients at risk for associated medical conditions. […] This article illustrates a variety of presentations of acanthosis nigricans associated with insulin resistance. […] Dermatologists should search for acanthosis nigricans in obese patients in order to identify those patients requiring intervention for the prevention of the systemic adverse effects of hyperinsulinemia. […] The most effective treatment is weight loss and exercise to correct the underlying endocrinologic abnormality.

• #1 Acanthosis Nigricans Treatment Brisbane – Dr Davin Lim

  https://drdavinlim.com/acanthosis-nigricans-treatment/

  Acanthosis nigricans present as dark patches involving the underarms, back of the neck groin areas. Extensively it can present as pigmentation of the face. This condition requires a multidisciplinary approach, including skin care, lasers, lifestyle dietary modifications. […] The best treatment is a combined approach of skin directed treatments metabolic modifications. […] The biggest traction is with dietary lifestyle modifications. […] Weight loss, diabetes management, close monitoring of blood sugars form the cornerstone of management. […] One of the underlying causes of AN is obesity or a higher than average BMI. Weight loss can help resolve the issue of AN, improving pigmentation dark patches. […] Do not underestimate the value of a dietician in the management of AN. They are integral to keeping your weight down, in addition to carefully selecting food to help you maintain a consistent blood sugar level.

• #1 Acanthosis nigricans: Foothill Dermatology Medical Center: Dermatology

  https://www.foothillderm.com/blog/acanthosis-nigricans

  Acanthosis nigricans: This skin condition causes areas of skin to darken and thicken as shown here on this 15-year-old girl’s hands. […] If you have pre-diabetes, making some lifestyle changes can help prevent diabetes. […] Studies show that many obese people see the dark patches on their skin clear when they lose a significant amount of weight. […] Maintain a healthy weight. Obesity is the most common cause of AN in adults and children. Studies have found that peoples skin often clears completely with significant weight loss. You can find out what your healthy weight is by calculating your body mass index. […] Find out if you have a medical condition that is causing AN. Diabetes and other medical conditions can cause AN. Doing things that improve the medical condition often help to clear the skin. […] If you suddenly see many dark, velvety patches on your skin, immediately make an appointment to see your dermatologist or primary care doctor. This can be a sign of cancer.

• #1 Acanthosis nigricans: Causes, Symptoms, Treatment and Cost

  https://www.lybrate.com/topic/acanthosis-nigricans

  Maintaining a healthy weight involves eating a balanced diet, working out often, and limiting drastic weight changes. […] Manage existing conditions: Manage underlying medical conditions, such as diabetes and hormonal disorders, to avoid exacerbating existing symptoms. […] Reduce the use of certain lotions and cosmetics, which could worsen the condition in some cases. […] Consider dietary modifications such as limiting intake of sugary foods or those with high sodium content. […] Practise good skin hygiene by washing regularly with mild soap and avoiding lotions containing irritants or exfoliants that may lead to skin irritation or injury. […] Eating a healthy diet low in saturated fats and carbohydrates can help reduce symptoms of acanthosis nigricans. […] Being overweight or obese is a major risk factor for acanthosis nigricans, so medical professionals often recommend trying to lose weight as part of treatment.

• #1 Acanthosis Nigricans: Background, Pathophysiology, Etiology

  https://emedicine.medscape.com/article/1102488-overview

  Patients should be informed that AN is not a skin disease per se but, rather, a sign of an underlying problem. If a patient does have AN related to insulin resistance, which is the most common association, treatment of the metabolic abnormality may lead to improvement of the appearance of the skin. Dietary changes and weight loss may cause AN to regress almost completely.

• #1 Acanthosis Nigricans (for Teens) | Nemours KidsHealth

  https://kidshealth.org/en/teens/acanthosis.html

  Eating a healthy diet and getting regular physical activity can help lower insulin levels and improve skin appearance. It can help to: […] Losing weight will help acanthosis nigricans fade. If youre concerned about your weight, talk to your doctor before going on a diet.

• #1 Acanthosis nigricans

  https://www.pcds.org.uk/clinical-guidance/acanthosis-nigricans

  There is no reliably effective treatment. […] The primary aim is to correct the underlying cause, which, if possible can lead to an improvement in symptoms: Weight loss. […] Where appropriate, correct hyperinsulinaemia through diet and medication including metformin. […] If possible, stop causal medication in drug-induced AN. […] Patients with suspected malignant AN need an urgent referral. Such patients need a thorough workup for underlying malignancy, although occasionally malignant AN can precede internal manifestations.

• #1 Acanthosis Nigricans: Causes, Diagnosis, and Treatment

  https://dermnetnz.org/topics/acanthosis-nigricans

  Treatment of acanthosis nigricans can also be undertaken for cosmetic reasons. […] Outcomes depend on the cause. Acanthosis nigricans may be a vital marker of underlying conditions which themselves carry significant risk to overall morbidity and mortality, such as obesity, metabolic syndrome, diabetes, and even serious internal malignancies. […] If the underlying etiology can be addressed, such as through weight loss interventions, then the acanthosis nigricans is expected to improve or fully resolve.

• #2 Acanthosis Nigricans: Background, Pathophysiology, Etiology

  https://emedicine.medscape.com/article/1102488-overview

  Patients should be informed that AN is not a skin disease per se but, rather, a sign of an underlying problem. If a patient does have AN related to insulin resistance, which is the most common association, treatment of the metabolic abnormality may lead to improvement of the appearance of the skin. Dietary changes and weight loss may cause AN to regress almost completely.

• #2 Acanthosis nigricans: Foothill Dermatology Medical Center: Dermatology

  https://www.foothillderm.com/blog/acanthosis-nigricans

  Acanthosis nigricans: This skin condition causes areas of skin to darken and thicken as shown here on this 15-year-old girl’s hands. […] If you have pre-diabetes, making some lifestyle changes can help prevent diabetes. […] Studies show that many obese people see the dark patches on their skin clear when they lose a significant amount of weight. […] Maintain a healthy weight. Obesity is the most common cause of AN in adults and children. Studies have found that peoples skin often clears completely with significant weight loss. You can find out what your healthy weight is by calculating your body mass index. […] Find out if you have a medical condition that is causing AN. Diabetes and other medical conditions can cause AN. Doing things that improve the medical condition often help to clear the skin. […] If you suddenly see many dark, velvety patches on your skin, immediately make an appointment to see your dermatologist or primary care doctor. This can be a sign of cancer.

• #2 Acanthosis Nigricans – What You Need to Know

  https://www.drugs.com/cg/acanthosis-nigricans.html

  What can I do to manage or prevent AN? […] Reach or maintain a healthy weight. AN skin patches often clear up after weight loss. Your healthcare provider can help you create a safe weight loss plan if you are overweight. […] Eat healthy foods. Healthy foods can help control your blood sugar levels. Examples of healthy foods include fruits, vegetables, whole-grain breads, low-fat dairy products, beans, lean meats, and fish. Your healthcare provider or dietitian can help you create a healthy meal plan. […] Exercise regularly. Exercise can help control your blood sugar level. Exercise can also help you manage your weight or lose weight. Try to get at least 30 minutes of exercise every day on most days of the week, or as directed. […] Use gentle skin care products. Some skin care products can irritate your skin and make AN worse. Ask your healthcare provider which skin care products you should use. He or she may also be able to prescribe or recommend soaps if the patches have an odor.

• #2 Acanthosis Nigricans – Kidshealth | Akron Children’s

  https://www.akronchildrens.org/kidshealth/en/parents/acanthosis.html

  Eating a healthy diet and getting regular physical activity can help lower insulin levels and improve skin appearance. Try these tips: […] Choose whole grains and plenty of fruits and vegetables. […] Offer water or low-fat milk instead of soda, juice, or other sugary drinks. […] Limit highly processed foods, fatty foods, and sugary treats. […] Encourage your child to be physically active every day.

• #2 Black Neck Solutions: Acanthosis Nigricans Treatment Guide

  https://evaskinclinicpune.com/blogs/acanthosis-nigricans-treatment/

  Essential Preventive Tips: […] Losing weight is related to obesity. […] Replace refined carbohydrates with whole-grain foods. […] Consume foods rich in fiber such as fresh fruits vegetables. […] Minimize snacking on foods with high saturated fats like samosas, pastries, chips biscuits. […] Drink low-fat milk or skim milk instead of whole milk. On similar lines, wheat bread instead of milk bread. […] Eat low-fat meals. […] Drinks plenty of water. […] Exercise regularly. […] Manage stress anxiety. […] Treat underlying problems like diabetes, and hypothyroidism. […] Stay away from medications aggravating or worsening the condition.

• #2 Acanthosis Nigricans (AN) | Nationwide Children’s Hospital

  https://www.nationwidechildrens.org/conditions/acanthosis-nigricans

  Acanthosis nigricans is a skin condition characterized by dark, thick, velvety patches of skin in body folds and creases. […] The good news is that taking control over your weight — learning to eat well, being active and losing some weight — lowers the amount of unused insulin in your body. This will help get rid of AN. […] Losing weight will be an important part of your care plan. Here are a few tips you can use: […] The more calories you burn up, the better your body uses insulin. You dont have to start running marathons. But make sure that you do something active every day.

• #2 Acanthosis nigricans: Appearance, causes, and treatment

  https://www.medicalnewstoday.com/articles/324062

  Acanthosis nigricans does not have a specific cure, but treating the underlying cause can allow it to fade over time. Some topical treatments may also reduce its appearance. […] Treatment for the cause of acanthosis nigricans may involve: Weight management: Maintaining a moderate weight may help improve insulin sensitivity in those with insulin resistance. In turn, skin symptoms may improve. […] Managing blood sugar: People with type 2 diabetes may need medications, monitoring of blood sugar levels, and some dietary and lifestyle adjustments. Once blood sugar levels become stable, acanthosis nigricans symptoms may resolve. […] Balancing hormones: Medication and lifestyle adjustments may help reduce symptoms of acanthosis nigricans in those with hormonal conditions such as PCOS. […] Treatment for malignant acanthosis nigricans includes surgical removal of a cancerous tumor. Other treatments a person may need include chemotherapy and radiation therapy. […] Treating an underlying condition may improve skin symptoms. Some topical and cosmetic treatments may also help.

• #2 Remission of acanthosis nigricans in a teenager after treatment with metformin | ECE2015 | 17th European Congress of Endocrinology | Endocrine Abstracts

  https://www.endocrine-abstracts.org/ea/0037/ea0037ep1328

  Remission of acanthosis nigricans in a teenager after treatment with metformin […] Metformin may be an effective treatment option in some cases of acanthosis nigricans. […] Larger studies are necessary to establish the efficacy and safety of agents that reduce hyperinsulinaemia and insulin resistance in the treatment of acanthosis nigricans.

• #2 Acanthosis Nigricans

  https://drkothiwalaskineva.com/medical-dermatology/acanthosis-nigricans/

  Acanthosis nigricans may be associated with some internal illness so with help of some investigations all possible association should be ruled out. […] Treatment for underlying factors […] Weight loss […] Treatment of diabetes or insulin resistance if present. […] Avoid medicines which may result in fast weight gain. […] With all treatments it is possible that acanthosis nigricans does not improve but you should adapt some lifestyle modification and minimal treatment so that it doesn’t worsen. […] Don’t rub the affected skin […] Weight control […] Lifestyle modification […] If family history of obesity or acanthosis nigricans present, start lifestyle modification in advance […] At early stage it can be reversed so stick to doctors’ advice for best results.

• #2 Acanthosis Nigricans: Causes, Diagnosis &Treatment

  https://my.clevelandclinic.org/health/diseases/12168-acanthosis-nigricans

  If obesity is causing AN, you can help prevent the condition through weight management. A diet that helps you keep your blood sugar (insulin) levels in check can also help prevent AN. […] Other preventive steps include: Managing medical conditions related to AN, such as thyroid problems and diabetes. Avoiding medications, such as birth control pills, that can cause or worsen AN.

• #2 Acanthosis Nigricans: Causes, Symptoms, Diagnosis & Treatment

  https://www.webmd.com/skin-problems-and-treatments/acanthosis-nigricans-overview

  When acanthosis nigricans is related to obesity, weight management is an important part of prevention. A diet that contributes to reduced insulin also can help prevent acanthosis nigricans. […] Other ways to prevent the condition include treating related medical problems like hypothyroidism and avoiding medications that tend to cause or worsen the condition (like birth control pills).

• #2 Current treatment options for acanthosis nigricans | CCID

  https://www.dovepress.com/current-treatment-options-for-acanthosis-nigricans-peer-reviewed-fulltext-article-CCID

  Oral metformin and combinations of other insulin-mediating medications are effective, as they are therapies aimed at resolving the underlying causes contributing to AN. […] For cosmetic treatment, topical retinoids are considered the first-line therapy for insulin-resistant AN by modifying keratinization rate. […] An important consideration when evaluating a patient with AN is the potential for psychological distress. […] While correction of underlying causes remains the mainstay of treatment, it is important to consider cosmetic options to improve patient quality of life that may be affected by the presence of AN lesions.

• #2 Acanthosis Nigricans Treatment Brisbane – Dr Davin Lim

  https://drdavinlim.com/acanthosis-nigricans-treatment/

  Acanthosis nigricans present as dark patches involving the underarms, back of the neck groin areas. Extensively it can present as pigmentation of the face. This condition requires a multidisciplinary approach, including skin care, lasers, lifestyle dietary modifications. […] The best treatment is a combined approach of skin directed treatments metabolic modifications. […] The biggest traction is with dietary lifestyle modifications. […] Weight loss, diabetes management, close monitoring of blood sugars form the cornerstone of management. […] One of the underlying causes of AN is obesity or a higher than average BMI. Weight loss can help resolve the issue of AN, improving pigmentation dark patches. […] Do not underestimate the value of a dietician in the management of AN. They are integral to keeping your weight down, in addition to carefully selecting food to help you maintain a consistent blood sugar level.

• #2 Acanthosis Nigricans: Key Symptoms and Treatment Options

  https://www.bajajallianz.com/blog/wellness/symptoms-and-treatment-of-acanthosis-nigricans.html

  While not all cases of acanthosis nigricans can be prevented, adopting certain lifestyle changes might lower the risk of developing the condition: […] Maintain a Healthy Weight: Keeping your weight within a moderate range can reduce the risk of insulin resistance and related skin issues. […] Monitor Blood Sugar Levels: Regularly checking your blood glucose can help in the early detection and management of insulin resistance. […] Balanced Diet: Focus on a diet rich in whole foods, low in refined sugars, and balanced in carbohydrates, fats, and proteins. […] Stay Hydrated: Proper hydration supports overall skin health. […] Routine Medical Check-ups: Regular visits to your healthcare provider can help detect underlying health issues that may lead to acanthosis nigricans early.

• #2 Acanthosis nigricans in the pediatric population: a narrative review of the current approach to management in primary care – Pollock – Pediatric Medicine

  https://pm.amegroups.org/article/view/6555/html

  Acanthosis nigricans (AN) is frequently seen in obese and overweight children and adolescents. […] Early metabolic screening with focus on insulin sensitivity, liver function, lipid panel, and glucose tolerance is recommended. […] A thorough investigation and appropriate screening of children at risk, with a focus on early identification of the dermatologic condition and its associated comorbidities in the primary care setting, and early treatment is recommended to prevent long term consequences and decrease the risk of cardiovascular complications. […] The most effective first line treatment for AN is weight loss, through both dietary modification and physical activity, to improve underlying hyperinsulinemia and dyslipidemia, and in addition to weight and metabolic control, dermatologic treatment may be implemented. […] Appropriate screening, and identifying AN among children who are at risk for developing metabolic syndrome, will allow for earlier implementation of preventive measures to better control metabolic risk factors, decreasing the risk of cardiovascular complications.

• #2 Acanthosis nigricans: Causes, Symptoms, Treatment and Cost

  https://www.lybrate.com/topic/acanthosis-nigricans

  Maintaining a healthy weight involves eating a balanced diet, working out often, and limiting drastic weight changes. […] Manage existing conditions: Manage underlying medical conditions, such as diabetes and hormonal disorders, to avoid exacerbating existing symptoms. […] Reduce the use of certain lotions and cosmetics, which could worsen the condition in some cases. […] Consider dietary modifications such as limiting intake of sugary foods or those with high sodium content. […] Practise good skin hygiene by washing regularly with mild soap and avoiding lotions containing irritants or exfoliants that may lead to skin irritation or injury. […] Eating a healthy diet low in saturated fats and carbohydrates can help reduce symptoms of acanthosis nigricans. […] Being overweight or obese is a major risk factor for acanthosis nigricans, so medical professionals often recommend trying to lose weight as part of treatment.

• #2 Acanthosis nigricans in obese patients: Presentations and implications for prevention of atherosclerotic vascular disease

  https://escholarship.org/uc/item/6fj340w2

  Acanthosis nigricans is traditionally characterized by hyperpigmented, velvety plaques of body folds. […] The dermatologist has an important role in identifying the subset of obese patients with acanthosis nigricans. […] It is essential for dermatologists to recognize the many presentations of acanthosis nigricans to identify patients at risk for associated medical conditions. […] This article illustrates a variety of presentations of acanthosis nigricans associated with insulin resistance. […] Dermatologists should search for acanthosis nigricans in obese patients in order to identify those patients requiring intervention for the prevention of the systemic adverse effects of hyperinsulinemia. […] The most effective treatment is weight loss and exercise to correct the underlying endocrinologic abnormality.

• #3 Integrative Medicine Approach to Acanthosis Nigricans: Specialty Testing, Dietary Modifications and Cosmetic Treatment Options

  https://www.rupahealth.com/post/integrative-medicine-approach-to-acanthosis-nigricans

  Acanthosis nigricans is more than just a skin condition. […] Managing this condition often requires an integrative approach, combining changes in lifestyle, diet, cosmetic interventions, and the use of medications to help manage symptoms. Addressing the underlying factors may significantly improve this condition. […] As acanthosis nigricans is often related to dysregulated insulin levels and obesity, a diet that takes this into consideration is important. Eating a nutrient-dense diet focused on maintaining steady insulin levels and avoiding processed foods may help manage this condition by attending to the underlying factors. […] For those seeking cosmetic solutions to acanthosis nigricans, topical retinoids are often considered. […] An integrative approach combining testing, medications/supplements, diet changes, and physical activity can help manage the condition by addressing the underlying factors.

• #3 Acanthosis nigricans – Point Pleasant Beach, Linden and Staten Island, NJ Dermatologist

  https://www.patriciamccormackmd.com/acanthosis-nigricans/

  Studies show that many obese people see the dark patches on their skin clear when they lose a significant amount of weight. […] Maintain a healthy weight. Obesity is the most common cause of AN in adults and children. Studies have found that peoples skin often clears completely with significant weight loss. You can find out what your healthy weight is by calculating your body mass index. […] Find out if you have a medical condition that is causing AN. Diabetes and other medical conditions can cause AN. Doing things that improve the medical condition often help to clear the skin. […] Find out if a medicine you take is causing AN. Some medicines can cause AN. Be sure to tell your dermatologist about all the medicines you take. If medicine is causing your AN, you may be able to switch to another medicine.

• #3 Acanthosis Nigricans Causes & Symptoms | Pigmentation Treatment | FMS Skin & Hair Clinics

  https://www.fmsskin.com/acanthosis-nigricans/

  Acanthosis nigricans is a skin condition characterized by dark, velvety patches of skin that typically appear in body folds and creases, such as the neck, armpits, groin, and under the breasts. […] Understanding the causes, associated risk factors, and treatment options for acanthosis nigricans can help in managing the condition and addressing the underlying issues that contribute to its development. […] The treatment of acanthosis nigricans focuses on addressing the underlying cause of the condition. […] Weight loss is often recommended for individuals with acanthosis nigricans who are overweight or obese. […] Making certain lifestyle changes can play a significant role in managing acanthosis nigricans and preventing its progression: […] A balanced diet that is rich in whole grains, fruits, vegetables, lean proteins, and healthy fats can help manage insulin resistance and support overall health. […] Engaging in regular physical activity can help improve insulin sensitivity, promote weight loss, and reduce the risk of developing type 2 diabetes. […] Practicing good skin hygiene and using gentle skin care products can help prevent irritation and maintain the health of the affected skin.

• #3 Common Hyperpigmentation Disorders in Adults: Part II. Melanoma, Seborrheic Keratoses, Acanthosis Nigricans, Melasma, Diabetic Dermopathy, Tinea Versicolor, and Postinflammatory Hyperpigmentation | AAFP

  https://www.aafp.org/pubs/afp/issues/2003/1115/p1963.html

  Acanthosis nigricans, usually related to insulin resistance or obesity, ranges in appearance from a thickened, velvety brown streaking to a leathery, verrucous, papillomatous lesion. […] It is important for physicians to recognize acanthosis nigricans, because the condition can be associated with insulin resistance (as occurs in type 2 diabetes and polycystic ovary syndrome), obesity and, occasionally, malignancy. […] Treatment of acanthosis nigricans is directed at the underlying cause, rather than the appearance of the skin. If present, insulin resistance should be managed appropriately. Screening for hypercholesterolemia and coronary artery disease may be appropriate, depending on the clinical picture.

• #3 Acanthosis Nigricans Treatment Brisbane – Dr Davin Lim

  https://drdavinlim.com/acanthosis-nigricans-treatment/

  AN is complicated, often requires a team of healthcare professionals to effectively manage this condition. […] The biggest traction is reduction of weight (if this is present). Most require pharmacological management, a few can do it with diet. Metformin orally at 1000 to 1500 mg can be considered as adjunctive treatment in those who have high BMI or impaired sugars.

• #3 Acanthosis nigricans in the pediatric population: a narrative review of the current approach to management in primary care – Pollock – Pediatric Medicine

  https://pm.amegroups.org/article/view/6555/html

  Acanthosis nigricans (AN) is frequently seen in obese and overweight children and adolescents. […] Early metabolic screening with focus on insulin sensitivity, liver function, lipid panel, and glucose tolerance is recommended. […] A thorough investigation and appropriate screening of children at risk, with a focus on early identification of the dermatologic condition and its associated comorbidities in the primary care setting, and early treatment is recommended to prevent long term consequences and decrease the risk of cardiovascular complications. […] The most effective first line treatment for AN is weight loss, through both dietary modification and physical activity, to improve underlying hyperinsulinemia and dyslipidemia, and in addition to weight and metabolic control, dermatologic treatment may be implemented. […] Appropriate screening, and identifying AN among children who are at risk for developing metabolic syndrome, will allow for earlier implementation of preventive measures to better control metabolic risk factors, decreasing the risk of cardiovascular complications.

• #3 Acanthosis nigricans

  https://www.pcds.org.uk/clinical-guidance/acanthosis-nigricans

  There is no reliably effective treatment. […] The primary aim is to correct the underlying cause, which, if possible can lead to an improvement in symptoms: Weight loss. […] Where appropriate, correct hyperinsulinaemia through diet and medication including metformin. […] If possible, stop causal medication in drug-induced AN. […] Patients with suspected malignant AN need an urgent referral. Such patients need a thorough workup for underlying malignancy, although occasionally malignant AN can precede internal manifestations.

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