Materiały źródłowe

• #1 Schwannoma: What It Is, Causes, Symptoms & Treatment

  https://my.clevelandclinic.org/health/diseases/17877-schwannoma

  Unfortunately, schwannomas cant be prevented. In most cases, they happen randomly for unknown reasons. About 10% of cases are linked to certain genetic conditions that make it more likely that youll develop certain types of tumors. […] If you have a biological relative whos been diagnosed with neurofibromatosis 2 (NF2), Schwannomatosis or Carney complex, talk to your healthcare provider. They may recommend genetic counseling to see if you also have the genetic condition.

• #2 Schwannoma tumors | EBSCO Research Starters

  https://www.ebsco.com/research-starters/health-and-medicine/schwannoma-tumors

  Schwannomas cannot be prevented. […] The prognosis is good with early diagnosis and surgery but worsens if the tumor is detected at a later stage.

• #3 Schwannoma – DoveMed

  https://www.dovemed.com/diseases-conditions/schwannoma

  Current medical research has not established a way of preventing Schwannoma. However, in case it is associated with genetic disorders, such as neurofibromatosis type 2, then the following may be considered: […] Genetic testing of the expecting parents (and related family members) and prenatal diagnosis (molecular testing of the fetus during pregnancy) may help in understanding the risks better during pregnancy […] If there is a family history of the condition, then genetic counseling will help assess risks before planning for a child […] Active research is currently being performed to explore the possibilities for treatment and prevention of inherited and acquired genetic disorders such as neurofibromatosis type 2 […] Regular medical screening at periodic intervals with tests and physical examinations are strongly recommended.

• #4 Vestibular schwannoma or acoustic neuroma | Hôpital de La Tour

  https://www.la-tour.ch/en/vestibular-schwannoma-or-acoustic-neuroma

  To date, there are no effective preventive measures to avoid the development of sporadic vestibular schwannoma. As the exact causes of this benign tumour are still poorly understood, it is not possible to identify modifiable risk factors to prevent its development. In the absence of prevention, early diagnosis remains one of the best ways of avoiding complications associated with the tumour’s development. […] Can a vestibular schwannoma be prevented? There is no effective prevention. Certain genetic diseases such as neurofibromatosis type 2 (NF2) increase the risk. Medical monitoring is recommended for people with a family history.

• #5 Schwannoma Treatment in Delhi, India | Symptoms & Causes

  https://www.blkmaxhospital.com/our-specialities/cancer-centre/conditions-treatments/schwannoma

  There is not much information available on the primary prevention of schwannoma. […] Since they are hard to diagnose, it is important to always be aware of the symptoms. […] Early diagnosis is the key to preventing any serious consequences of schwannoma. […] If the patient has any family history of schwannoma, getting regular checkups and consulting a doctor in case of having any key symptoms will help. […] There is no information available on secondary prevention of schwannomas. […] Depending on the size and the location, if the entire tumour is removed surgically, the recurrence of schwannoma does not happen.

• #6 Neurofibrosarcoma and Schwannoma

  https://www.webmd.com/cancer/neurofibrosarcoma-and-schwannoma

  Since doctors dont know what causes most schwannomas and neurofibrosarcomas, there isn’t a specific way to prevent them. […] There are a few risk factors for neurofibrosarcomas though. So, inform your doctor if you develop any symptoms and have risk factors such as: […] Previous radiation therapy for cancer (neurofibrosarcoma could develop in the treated area 10 to 20 years later) […] Presence of a noncancerous nerve tumor, such as a neurofibroma […] A family history of neurofibromatosis.

• #7 Acoustic Neuroma (Vestibular Schwannoma)

  https://www.baptisthealth.com/care-services/conditions-treatments/acoustic-neuroma

  There is no way to prevent acoustic neuromas from developing. […] It is important to consult with your doctor if you start noticing symptoms of hearing loss and balance issues. […] The earlier you start treatment the better the treatment outcomes and less risk of complications.

• #8 Why Consider Aspirin for the Treatment of Vestibular Schwannoma? A Brief Review and Randomized, Double‐Blind, Placebo‐Controlled Study Proposal

  https://pmc.ncbi.nlm.nih.gov/articles/PMC11960480/

  The primary objective of this study is to review the evidence for aspirin use to prevent the growth of vestibular schwannomas (VS) and to propose a prospective trial to determine the progression-free survival of VS patients after up to 42 months of treatment with aspirin. […] The retrospective reviews on the utility of aspirin to prevent VS growth are inconclusive. […] The use of aspirin for the treatment of VS was reported in a retrospective study finding decreased growth in VS, and mechanistic studies with primary human VS cells in vitro found aspirin to be cytostatic. […] This finding suggested that aspirin may inhibit VS growth and was confirmed with a subsequent volumetric analysis. […] Despite the affirming mechanistic and bioinformatic studies highlighting the central role of inflammation in VS progression, two subsequent retrospective clinical studies failed to show aspirin associated with a reduced risk of VS growth.

• #9 Why Consider Aspirin for the Treatment of Vestibular Schwannoma? A Brief Review and Randomized, Double‐Blind, Placebo‐Controlled Study Proposal

  https://pmc.ncbi.nlm.nih.gov/articles/PMC11960480/

  Aspirin has been used for the primary prevention of cardiovascular disease (CVD) and the prevention of colorectal cancer (CRC). […] As the benefit of aspirin to patients with VS is yet unknown, potential study subjects and their primary care physicians should consider the relatively weak evidence for and against aspirin prophylaxis of CVD and CRC. […] Patients may benefit from halted or reduced tumor growth. […] The current study incorporates biomarker analysis, such as TNF and prostaglandin E2 levels, as well as confirms serum levels of salicylates in study participants. […] The authors encourage referral and patient participation.

• #10 New experimental treatment can stop the growth of schwannoma tumours – University of Plymouth

  https://www.plymouth.ac.uk/news/new-experimental-treatment-can-stop-the-growth-of-schwannoma-tumours

  Nowe badania wykazały, że dwa nowatorskie leki podawane doustnie mogą nie tylko zablokować wzrost, ale także zmniejszyć rozmiar guzów typu schwannoma. […] Dr Laraba, który ukończył pracę w ramach swojego doktoratu, powiedział: Jesteśmy naprawdę podekscytowani, że blokowanie szlaku Hippo jest bardzo skuteczne w zapobieganiu wzrostowi schwannoma i meningioma. […] Profesor Parkinson, starszy autor badania, dodał: Nasze obecne badanie daje wczesny sygnał, że możemy potencjalnie zapewnić pacjentom ze schwannoma skuteczną alternatywną terapię w zarządzaniu ich stanem. […] Dla tych pacjentów perspektywa jednego leku, który mógłby leczyć oba typy guzów bez potrzeby inwazyjnej i ryzykownej operacji, jest z pewnością ekscytującą perspektywą.

• #11 New experimental treatment can stop growth of schwannoma tumors

  https://medicalxpress.com/news/2022-11-experimental-treatment-growth-schwannoma-tumors.html

  Dr. Laraba, who completed the work as part of his Ph.D. research, said, „We are really excited to show that blocking the Hippo pathway is highly effective in preventing schwannoma and meningioma growth. These drugs are well tolerated in our models and we hope that our work can stimulate and accelerate the use of these inhibitors in clinical trials.” […] Professor Parkinson, the study’s senior author, added, „Our current study gives an early indication that we can potentially provide schwannoma patients with a successful alternative treatment to manage their condition. However, patients with Neurofibromatosis Type 2 often have both schwannoma and meningioma tumors in their nervous system. For those patients, the prospect of a single drug that could treat both tumor types without the need for intrusive and risky surgery is clearly an exciting prospect.”

• #12 New experimental treatment can stop the growth of schwannoma tumors | ScienceDaily

  https://www.sciencedaily.com/releases/2022/11/221108120242.htm

  Dr Laraba, who completed the work as part of his PhD research, said: „We are really excited to show that blocking the Hippo pathway is highly effective in preventing schwannoma and meningioma growth. […] Professor Parkinson, the study’s senior author, added: „Our current study gives an early indication that we can potentially provide schwannoma patients with a successful alternative treatment to manage their condition.”

• #13 Early Nerve Tumor Treatment Prevents Problems, Study Finds

  https://newsroom.uvahealth.com/2024/11/12/vestibular_schwannomas/

  Patients with a small cranial nerve tumor that can cause hearing loss, vertigo, imbalance and ringing in the ears have typically been watched rather than proactively treated, as the risks of early intervention were thought to outweigh the benefits. […] However, even those patients benefit significantly from non-invasive stereotactic radiosurgery, a multicenter, international study led by UVA Health physicians has found. […] Their findings demonstrated that stereotactic radiosurgery a highly targeted form of radiation therapy can prevent small tumors from growing over time while at the same time sparing patients from potentially irreversible problems in the future. […] This study and our recent Vestibular Schwannoma International Study of Active Surveillance versus Stereotactic Radiosurgery [VISAS] trial demonstrate that radiosurgery affords effective and durable tumor control while more often avoiding the neurological complications that come from watching a vestibular schwannoma, Sheehan said. […] Acting early, before symptoms develop, could greatly improve patients long-term quality of life, he says. […] This study shows that Gamma Knife radiosurgery substantially improves the future trajectory of vestibular schwannoma patients.

• #14 Facial nerve injury in acoustic neuroma (vestibular schwannoma) surgery: etiology and prevention in: Journal of Neurosurgery Volume 87 Issue 1 (1997) Journals

  https://thejns.org/view/journals/j-neurosurg/87/1/article-p60.xml

  Facial nerve injury associated with acoustic neuroma surgery has declined in incidence but remains a clinical concern. […] The etiology of facial nerve injury is discussed with emphasis on the pathophysiology of facial nerve palsy. In addition, on the basis of the authors’ experience with these complex tumors, techniques of preventing facial nerve injury are discussed.

• #15 Postoperative hemorrhages in vestibular schwannoma surgery pontine hemorrhage. Clinical case report – Rudenko – Annals of Clinical and Experimental Neurology

  https://annaly-nevrologii.com/journal/pathID/article/view/1084

  Hemorrhage in the brain stem structures is a rare and life-threatening postoperative complication in vestibular schwannoma surgery. […] Comprehensive assessment of the tumor blood supply status, the state of the brainstem, intra- and postoperative clinical and neurophysiological monitoring, careful and thorough dissection of the tumor capsule and strict control of blood pressure in the postoperative period are the basis for the prevention of these complications. […] The postoperative hemorrhage prevention measures include thorough hemostasis with modern local hemostatics and BP control during the wound closure. […] V.N. Shimansky et al. emphasize the importance of detection and timely correction of arterial hypertension in the postoperative period as significant intracranial hemorrhage preventive measures.

• #16 Postoperative hemorrhages in vestibular schwannoma surgery pontine hemorrhage. Clinical case report – Rudenko – Annals of Clinical and Experimental Neurology

  https://annaly-nevrologii.com/journal/pathID/article/view/1084

  Thus, postoperative hemorrhage complications in VS surgery are rare but dangerous, being the leading cause of unfavorable treatment outcomes. The key predisposing factors are older age, large and giant size of the tumor, tumor invasion into the pia mater of the brainstem, and vascularization of the tumor stroma. Comprehensive assessment of tumor blood supply and the state of the brainstem, intra- and postoperative clinical and neurophysiological monitoring, careful and thorough dissection of tumor capsule and strict BP control in the postoperative period are the basic preventive measures for these complications.

• #17

  https://journals.lww.com/otology-neurotology/Fulltext/2010/04000/Prevention_of_Cerebrospinal_Fluid_Leak_After.19.aspx?generateEpub=Article%7Cotology-neurotology:2010:04000:00019%7C%7C

  Successful wound closure and CSF leak prevention after translabyrinthine craniotomy for the removal of vestibular schwannomas do not require the creation of a facial recess, manipulation of the ossicles, direct Eustachian tube plugging, or the use of alloplastic space-occupying materials. […] The closure technique used in the current study has proven effective over time with no evidence of CSF leak among patients seen in follow-up.

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