Materiały źródłowe

• #1 Cough – StatPearls – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK493221/

  A cough is the single most prevalent symptom on presentation to a providers office. Prevalence is heavily influenced by the social history of smoking tobacco usage and is estimated between 5% to 40%. The exact etiology of a cough determines the predilection of race and gender impact. […] Cough is one of the most common medical complaints accounting for as many as 30 million clinical visits per year. Up to 40% of these complaints result in a referral to a pulmonologist.

• #2 Cough – Wikipedia

  https://en.wikipedia.org/wiki/Cough

  A cough is the most common reason for visiting a primary care physician in the United States. […] Coughing is viewed as a public health issue.

• #3 Cough | 5-Minute Pediatric Consult

  https://peds.unboundmedicine.com/pedscentral/view/5-Minute-Pediatric-Consult/617210/all/Cough?q=Leukocytosis

  Cough is the most common symptom presenting to primary care physicians in the United States and worldwide. […] Chronic cough accounts for up to 38% of pulmonary outpatient visits. […] School-age children typically experience up to 10 instances of cough per day.

• #4 Cough epidemiology and demographics – wikidoc

  https://www.wikidoc.org/index.php/Cough_epidemiology_and_demographics

  The incidence/prevalence of cough is approximately 10 % of the adult population worldwide. […] The incidence/prevalence of cough is approximately 10 % of the adult population worldwide.

• #5 Prevalence, aetiologies and prognosis of the symptom cough in primary care: a systematic review and meta-analysis | BMC Primary Care | Full Text

  https://bmcprimcare.biomedcentral.com/articles/10.1186/s12875-021-01501-0

  Cough is a relevant reason for encounter in primary care. For evidence-based decision making, general practitioners need setting-specific knowledge about prevalences, pre-test probabilities, and prognosis. […] We identified 21 eligible studies on prevalence, 12 on aetiology, and four on prognosis. Prevalence/incidence estimates were 3.84.2%/12.5% (Western primary care) and 10.313.8%/6.36.5% in Africa, Asia and South America. […] Prevalences and incidences of cough are high and show regional variation. Acute cough, mainly caused by respiratory tract infections, is usually self-limiting (supporting a wait-and-see strategy). […] Our study presents epidemiological data under non non-pandemic conditions. It will be interesting to compare these data to future research results of the post-pandemic era.

• #6 Prevalence, aetiologies and prognosis of the symptom cough in primary care: a systematic review and meta-analysis | BMC Primary Care | Full Text

  https://bmcprimcare.biomedcentral.com/articles/10.1186/s12875-021-01501-0

  Our study identified 31 studies evaluating the symptom cough in primary care. Data quality was heterogeneous with only seven studies having an overall low risk of bias. The prevalence of cough in Western primary care was 3.84.2%; the incidence was 12.5%. African, Asian and South American healthcare settings showed higher prevalences (10.313.8%) and lower incidences (6.36.5%). […] A benign course of acute cough was also found by Bruyndonckx et al. A systematic review assessing primary, secondary, and tertiary care found a weighted mean duration of any cough of 17.8 days (range 15.3 to 28.6 days) and 13.9 days for productive cough (range 13.3 to 17.4 days). […] We found no death, a low rate of hospital admissions, an improvement in half of patients after three days and complete recovery in 79% of patients after one month. […] For future studies, we see a particular need in methodologically sound studies on the cause of subacute and chronic cough in Western primary care.

• #7 Epidemiology and Healthcare Service Utilization among Adults with Chronic Cough

  https://www.mdpi.com/2077-0383/13/11/3230

  Chronic cough (CC) is a prevalent yet underexplored medical condition, with limited real-world data regarding its healthcare burden. This study investigates the epidemiology, associated comorbidities, and healthcare service utilization among patients with CC. The study included 91,757 PwCC, reflecting a prevalence of 5.5%. Of those, 59,296 patients were first diagnosed with CC during the study period, representing a 10-year incidence rate of 3.26%. Diseases associated with the highest OR for CC included lung cancer (OR = 3.32), whooping cough (OR = 3.04), and respiratory infections (OR = 2.81). Furthermore, PwCC demonstrated increased healthcare service utilization, leading to a higher adjusted annual estimated mean cost (USD 4038 vs. USD 1833). Chronic cough emerges as a relatively prevalent complaint within community care, exerting a considerable economic burden. This study underscores the need for heightened awareness, comprehensive management strategies, and resource allocation to address the multifaceted challenges associated with chronic cough.

• #8 Causes and epidemiology of subacute and chronic cough in adults – UpToDate

  https://www.uptodate.com/contents/evaluation-of-subacute-and-chronic-cough-in-adults

  Causes and epidemiology of subacute and chronic cough in adults […] The symptom of cough is one of the most common symptoms for which adult outpatient care is sought. […] The physiology of the cough reflex arc and common etiologies of subacute and chronic cough will be reviewed here. […] Cough in adults can be classified based upon the duration of the cough at the time of presentation to the health care provider. […] This classification helps narrow the list of potential causes, although considerable overlap exists. […] Acute cough – Present for up to three weeks […] Subacute cough – Present for three to eight weeks.

• #9 Epidemiology of unexplained chronic cough in adults: a population-based study

  https://pmc.ncbi.nlm.nih.gov/articles/PMC10204850/

  Chronic cough is defined in adults as a cough that lasts for 8 weeks. It affects 21.8% of adults and is commonly associated with smoking and medical conditions such as asthma and COPD. Importantly, rather than being a symptom of underlying disease, unexplained chronic cough (UCC) may exist as a distinct entity characterised by neural hypersensitivity and neuroimmune dysfunction, also known as cough hypersensitivity syndrome. UCC has significant psychosocial impact on patients and it is difficult to treat. As there is no approved treatment for UCC at present, patients with UCC undergo therapeutic trials with a variety of medications, which sometimes result in unsatisfactory treatment response and adverse effects. […] According to existing literature, the prevalence of UCC ranges from 0.4% to 1.3% in the general adult population, and accounts for 1.4% to 8.7% of chronic cough cases in adults presenting to primary care and cough clinics. However, most of these studies were not population-based and did not primarily investigate the epidemiology of UCC in the general adult population, but rather in a healthcare setting. Presently, there are limited data on the epidemiological trends of UCC in adults. Therefore, we studied the prevalence, incidence and persistence of UCC in adult and elderly participants from the Rotterdam Study, a large prospective population-based cohort study.

• #10 :: JKMS :: Journal of Korean Medical Science

  https://jkms.org/DOIx.php?id=10.3346/jkms.2024.39.e273

  Chronic cough is a common symptom encountered by healthcare practitioners. The global prevalence of chronic cough is 9.6%, with a female predominance. […] The aim of our study is to reveal the sex differences in prevalence and severity of chronic cough in South Korea, stratified by age and etiology. […] The chronic cough population in Korea was predominantly female, with male-to-female ratio of 1:2.03. Female patients were older and had a higher prevalence of asthma/CVA than male patients. However, cough duration and severity were not different between the sexes. […] Global epidemiologic studies have repeatedly demonstrated sex-related differences in chronic cough. […] The male-to-female ratio in South Korea was 1:2.03, which is consistent with the ratios reported in previous global reports.

• #11 Characteristics, demographics, and epidemiology of possible chronic cough in Sweden: A nationwide register-based cohort study | PLOS One

  https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0303804

  The aim was to describe the real-world epidemiology of chronic cough in Sweden by using national register data. More specifically, to describe clinical characteristics and demographics as well as healthcare utilization including medical treatment of a population with possible chronic cough. […] During the study period, 256,046 individuals were initially identified with at least one ICD-10 diagnosis code of R05 and/or 2 dispenses of relevant cough-medication in the national cohort. After applying exclusion criteria, a total of 62,963 individuals were identified with PCC, corresponding to a prevalence of 787/100,000 among inhabitants of age 18 years. The mean age was 56 years, the majority were female, and 56% had possible UCC. The individuals identified from cough medicine dispenses only were on average, 9 years older than those identified with cough diagnosis only.

• #12 Characteristics, demographics, and epidemiology of possible chronic cough in Sweden: A nationwide register-based cohort study | PLOS One

  https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0303804

  Even though 44% of individuals with possible chronic cough had visited any cough relevant specialist clinic during the study period, only 41% of these individuals received a cough diagnosis code, meaning that less than 20% of the whole PCC cohort received a cough diagnosis. Cough medicines were mainly prescribed in primary care (82.5%). Treatment with other medications was rather common, where dispensed prescriptions for obstructive respiratory disease were most common. […] This nationwide observational register-based study contributes to a better understanding of individuals affected by refractory or unexplained chronic cough. Possible chronic cough (PCC) is more prevalent in females and increases with age with a peak around 40-69 years. The majority of individuals with PCC had frequently dispensed medical prescriptions, and a long history of PCC, although often without receiving a formal cough diagnosis. Pharmacological therapy often included the use of opioids. Most individuals with PCC were treated in primary care, without secondary care specialist referrals. This signifies a need for increased awareness of the condition, better treatments, and improved access to specialist care. Further studies are needed to establish how well register-based cohorts of PCC represent chronic cough individuals in general, and how severely they are affected by their cough, to further increase the understanding of this debilitating condition and improve patient care.

• #13 Epidemiology of unexplained chronic cough in adults: a population-based study

  https://pmc.ncbi.nlm.nih.gov/articles/PMC10204850/

  Our findings suggest that approximately one in five (21.2%) of all chronic cough cases in the general adult population are unexplained by common risk factors and associated medical conditions such as asthma, COPD, chronic rhinosinusitis, GORD and ACE-inhibitor use. The present study provides important insights into the epidemiology of UCC in a general population of adults and older subjects, demonstrating that two-thirds of UCC cases are self-limiting, and two-thirds of adults with persistently unexplained chronic cough and refractory chronic cough are women. In conclusion, UCC accounts for a considerable proportion of chronic cough cases in adults, and its persistent phenotype demonstrates female predominance. The demographic profile of adults with persistent UCC is similar to that of patients with cough hypersensitivity.

• #14 :: JKMS :: Journal of Korean Medical Science

  https://jkms.org/DOIx.php?id=10.3346/jkms.2024.39.e273

  Our study found that the age group of 50-59 years had the highest prevalence of chronic cough, consistent with results in previous research. […] In conclusion, this study demonstrated that sex disparities in cough prevalence, demographic characteristics, and severity varied significantly according to age category and etiology.

• #15

  https://journals.lww.com/md-journal/fulltext/2017/03310/point_prevalence_and_epidemiological.36.aspx

  We found that a considerable proportion of subjects with current cough had chronic cough (44% of current cough subjects), and that 2 subtypes of current cough, subacute and chronic cough, were notably more frequent in the elderly (aged 65 years). On multivariate analyses, older age, current smoking, and clinical parameters indicative of upper/lower airway pathology were significant determinants of chronic cough. […] Our present cross-sectional analysis showed that approximately 90% of current cough was acute or chronic (43.9% acute and 44.1% chronic). Cough persisting for less than 1 week formed the largest proportion of current cough (31.1%). The proportion of current cough that lasted for longer than 1 year constituted the second largest proportion (27.7%). This dual peak in the prevalence of current cough may suggest that self-limiting and chronic cough are intrinsically different. Such findings warrant longitudinal, observational cohort studies exploring the natural course of cough.

• #16

  https://journals.lww.com/md-journal/fulltext/2017/03310/point_prevalence_and_epidemiological.36.aspx

  In conclusion, we investigated the point prevalence and distribution pattern of current cough, and subtypes thereof, in terms of duration. Chronic cough constituted a considerably high proportion of current cough, and more in the elderly. The 2 peaks of cough duration suggest that the pathophysiology of acute and chronic cough differ. These findings warrant further longitudinal population cohort studies and also more sophistication and validation of tools to define chronic cough.

• #17 Syndromic surveillance of population-level COVID-19 burden with cough monitoring in a hospital emergency waiting room – ScienceOpen

  https://www.scienceopen.com/document?vid=fe8a24d7-8c1a-4947-8784-138aa60f3a8a

  Syndromic surveillance is an effective tool for enabling the timely detection of infectious disease outbreaks and facilitating the implementation of effective mitigation strategies by public health authorities. […] With recent advancements in ubiquitous sensing technologies, it becomes feasible to continuously measure population-level cough incidence in a contactless, unobtrusive, and automated manner. […] In this work, we demonstrate the utility of monitoring aggregated cough count as a syndromic indicator to estimate COVID-19 cases. […] Our analysis revealed a significant correlation between the aggregated cough count and positive COVID-19 cases in the hospital (Pearson correlation of 0.40, p-value < 0.001). [...] Our findings highlight that incorporating cough-counting based signals into syndromic surveillance systems can significantly enhance overall resilience against future public health challenges, such as emerging disease outbreaks or pandemics.

• #18 Synergistic Effects of β-NaFeO2 Ferrite Nanoparticles for Photocatalytic Degradation, Antibacterial, and Antioxidant Applications†

  https://digitalcommons.library.tmc.edu/uthmed_docs/1438/

  Syndromic surveillance is an effective tool for enabling the timely detection of infectious disease outbreaks and facilitating the implementation of effective mitigation strategies by public health authorities. […] the aggregated measurement of cough, an important symptom for many illnesses, is not widely employed as a syndromic signal. […] In this work, we demonstrate the utility of monitoring aggregated cough count as a syndromic indicator to estimate COVID-19 cases. […] Our analysis revealed a significant correlation between the aggregated cough count and positive COVID-19 cases in the hospital (Pearson correlation of 0.40, p-value p = 0.04), a widely used syndromic signal and screening tool for such diseases. […] Our findings highlight that incorporating cough-counting based signals into syndromic surveillance systems can significantly enhance overall resilience against future public health challenges, such as emerging disease outbreaks or pandemics.

• #19 Cough Science News, May 1, 2024

  https://www.hyfe.com/cough-news/cough-science-news-may-1-2024

  Could cough monitoring be effective syndromic surveillance for Covid-19 in a hospital waiting room? […] The study found a significant correlation between aggregated cough count collected by a sensor in an emergency room and positive Covid-19 cases in the hospital (Pearson correlation of 0.40). Predictions of Covid-19 based on cough count outperformed predictions based on the number of patients presenting with fever. […] Fever monitoring is a widely used but somewhat intrusive method of syndromic surveillance. Cough monitoring may provide a more passive, but still real-time, alternative, or it could be combined with fever to generate more accurate predictive models. Integrating cough monitoring into syndromic surveillance might improve our ability to manage the next pandemic. […] Dr Zimmer spoke with us about her research into the value of cough as a biomarker for improving respiratory outcomes, particularly in tuberculosis (TB). Through multiple studies, she is examining the potential of cough for screening for TB, as well as for monitoring treatment.

• #20 Acoustic surveillance of cough for detecting respiratory disease using artificial intelligence

  https://dadun.unav.edu/entities/publication/74ff87e2-c3bf-4713-8dc6-a9a23565166d

  Research question Can smartphones be used to detect individual and population-level changes in cough frequency that correlate with the incidence of coronavirus disease 2019 (COVID-19) and other respiratory infections? […] Results We followed-up 616 participants and collected 62 000 coughs. Coughs per hour surged around the time cohort subjects sought medical care (difference +0.77 coughs.h(-1); p=0.00001). There was a weak temporal correlation between aggregated coughs and the incidence of COVID-19 in the local population (ACF 0.43). […] Interpretation Artificial intelligence systems can detect changes in cough frequency that temporarily correlate with the onset of clinical disease at the individual level. A clearer correlation with population-level COVID-19 incidence, or other respiratory conditions, could be achieved with better penetration and compliance with cough monitoring.

• #21 Making cough count in tuberculosis care | Communications Medicine

  https://www.nature.com/articles/s43856-022-00149-w

  Cough assessment is central to the clinical management of respiratory diseases, including tuberculosis (TB), but strategies to objectively and unobtrusively measure cough are lacking. […] Acoustic epidemiology is an emerging field that uses technology to detect cough sounds and analyze cough patterns to improve health outcomes among people with respiratory conditions linked to cough. […] While much of the data are preliminary, objective cough assessment could potentially transform disease control programs, including TB, and support individual patient management. […] As coughing is a common TB symptom, it can be used to diagnose TB and assess effectiveness of treatment. […] This Perspective discusses advances in acoustic epidemiology and AI-based methods to assess cough and how these can be used during TB diagnosis and treatment.

• #22 Making cough count in tuberculosis care | Communications Medicine

  https://www.nature.com/articles/s43856-022-00149-w

  Cough monitoring, if validated, could also be useful as a starting point in identifying individuals with post-TB lung disease and related lung function decline. […] AI-based cough detection technology could also play a role in TB research and development. […] The development, validation, and roll-out of digital cough monitoring tools for TB will require global coordinated data collection, curation, and analysis effort.

• #23 An update on measurement and monitoring of cough: what are the important study endpoints? – Spinou – Journal of Thoracic Disease

  https://jtd.amegroups.org/article/view/3346/html

  Considerable progress has been achieved in the development of tools that assess cough. The Leicester cough questionnaire (LCQ) and the cough-specific quality of life questionnaire (CQLQ) are the most widely used health status questionnaires for adults with chronic cough. They are well validated for assessing the impact of cough. Cough frequency monitoring, the preferred tool to objectively assess cough, is increasingly being used as primary end-points in clinical trials. Cough should therefore be assessed with a combination of subjective and objective tools. Cough frequency assessment is considered the gold standard for the objective assessment of cough. Cough frequency monitors are now sufficiently practical for use in the clinic and clinical trials. Cough frequency monitors are considered an important end-point in clinical trials. Cough frequency can be expressed by a range of outcome measures. Cough monitors can potentially be used to validate the presence of cough. The clinical experience of using cough monitors to date is that they are practical and valid.

• #24

  https://www.who.int/health-topics/pertussis

  Pertussis, also known as whooping cough, is a highly contagious respiratory infection caused by the bacterium Bordetella pertussis. In 2018, there were more than 151 000 cases of pertussis globally. […] Pertussis spreads easily from person to person mainly through droplets produced by coughing or sneezing. […] People with pertussis are most contagious up to about 3 weeks after the cough begins, and many children who contract the infection have coughing spells that last 4 to 8 weeks. […] The best way to prevent pertussis is through immunization. […] In 2018, 86% of the global target population had received the recommended three doses of DTP-containing vaccine during infancy. […] Based on local epidemiology, further booster doses may be warranted later in life. […] National programmes may consider vaccination of pregnant women with pertussis-containing vaccine as a strategy additional to routine primary infant pertussis vaccination in countries or settings with high or increasing infant morbidity/mortality from pertussis.

• #25 Pertussis Surveillance and Trends | Whooping Cough | CDC

  https://www.cdc.gov/pertussis/php/surveillance/index.html

  CDC tracks pertussis cases using a national surveillance system. […] CDC works with several states on enhanced pertussis surveillance. […] Cases have increased over the last few decades but remain low. […] Experts believe that much of the disease goes unrecognized and unreported. […] The latest data reported to CDC are available online through the National Notifiable Diseases Surveillance System. […] State health departments then report pertussis cases to CDC through the National Notifiable Diseases Surveillance System (NNDSS). NNDSS is useful for monitoring epidemiologic trends in disease over time. […] CDC partners with seven states participating in the Emerging Infections Program network to conduct enhanced pertussis surveillance (EPS). […] This additional information goes beyond what CDC receives through NNDSS. […] Several factors have likely contributed to the increase in reported cases, including increased surveillance and reporting to public health departments. […] CDC continues to evaluate what impact, if any, molecular changes in B. pertussis are having on public health.

• #26 WHO EMRO | Disease surveillance | Pertussis | Health topics

  https://www.emro.who.int/health-topics/pertussis/disease-surveillance.html

  Surveillance of pertussis consists of a routine monthly report of aggregated data on clinical cases in countries with DPT3 coverage less than 90%. Reported data should be stratified by age. In countries with DPT3 coverage equal to or higher than 90%, case-based surveillance is recommended. Immediate investigation of all pertussis outbreaks with collection of case-based data is also recommended. In addition, sentinel surveillance is recommended in a few major hospitals to collect more in-depth information than that obtained through routine surveillance.

• #27 JMIR Public Health and Surveillance – Profiles of Cough and Associated Risk Factors in Nonhospitalized Individuals With SARS-CoV-2 Omicron Variant Infection: Cross-Sectional Online Survey in China

  https://publichealth.jmir.org/2024/1/e47453/

  Cough is a common symptom during and after COVID-19 infection; however, few studies have described the cough profiles of COVID-19. […] The aim of this study was to investigate the prevalence, severity, and associated risk factors of severe and persistent cough in individuals with COVID-19 during the latest wave of the Omicron variant in China. […] Cough was the most common symptom, occurring in 91.7% of participants, followed by fever, fatigue, and nasal congestion. […] Being female, having asthma, chronic cough, GERD, coronary heart disease, diabetes, and a COVID-19 vaccination history emerged as independent factors associated with severe cough, productive cough, and persistent cough. […] The epidemiology and clinical characteristics of COVID-19 have been widely studied; however, SARS-CoV-2 has continued to mutate from the dominant Alpha to Delta variants and now the Omicron variant and subvariants, and the clinical characteristics of COVID-19 also change according to the particular virus variant.

• #28 JMIR Public Health and Surveillance – Profiles of Cough and Associated Risk Factors in Nonhospitalized Individuals With SARS-CoV-2 Omicron Variant Infection: Cross-Sectional Online Survey in China

  https://publichealth.jmir.org/2024/1/e47453/

  Among these symptoms, cough is one of the most common. […] Studies in the United Kingdom and the United States have shown that the prevalence of acute cough during Omicron infection ranges from approximately 67.4% to 78%. […] However, few studies have described the specific cough features such as its severity, pattern, and risk factors. […] We hypothesized that certain risk factors might be related with severe cough, productive cough, and persistent cough after Omicron infection. […] The most common symptoms were cough, followed by fever, fatigue, and nasal congestion. […] Among the 10,741 respondents with cough, 44.0% presented with cough during both daytime and nighttime and 36.8% only had the cough during the daytime. […] With a cut-off VAS score of 70, 4388 (37.4%) of the total 11,718 respondents were categorized in the severe cough group.

• #29 Chronic cough: epidemiology, pathophysiology, diagnosis and management

  https://www.biomedcentral.com/collections/ccepdm

  BMC Pulmonary Medicine called for submissions to our Collection on Chronic cough: epidemiology, pathophysiology, diagnosis and management. Chronic cough significantly impacts physical and mental well-being, disrupting daily life and potentially leading to complications if underlying conditions remain untreated. Excessive coughing can significantly affect physical and mental health – it can disrupt daily life, leading to sleep disturbances, fatigue, and diminished productivity. […] Chronic cough remains a long-lasting and burdensome condition affecting a significant portion of the global population across all ages. Excessive coughing can significantly affect physical and mental health – it can disrupt daily life, leading to sleep disturbances, fatigue, and diminished productivity. The underlying conditions triggering chronic cough, if untreated, may escalate, potentially causing complications and compromising respiratory function. Multiple mechanisms and aetiologies may underlie chronic cough, making the disorder challenging to treat.

• #30

  https://link.springer.com/collections/cghhgeiaei

  Chronic cough remains a long-lasting and burdensome condition affecting a significant portion of the global population across all ages. […] Epidemiological studies on cough hypersensitivity and chronic cough. […] The mechanisms/pathophysiology of cough hypersensitivity and chronic cough. […] Diagnosis, screening and prevention. […] Management strategies. […] Psychosocial impact of chronic cough. […] Emerging research avenues for chronic cough management and treatment (e.g. personalized medicine).

• #31 Global Chronic Refractory Cough (CRC) Epidemiology Forecast Report 2021-2030: Focus on United States, Germany, Spain, Italy, France, United Kingdom and Japan – ResearchAndMarkets.com

  https://www.businesswire.com/news/home/20210513005609/en/Global-Chronic-Refractory-Cough-CRC-Epidemiology-Forecast-Report-2021-2030-Focus-on-United-States-Germany-Spain-Italy-France-United-Kingdom-and-Japan—ResearchAndMarkets.com

  The total prevalent population of Chronic Cough in the 7 major markets was estimated to be 84,854,266 in 2020. The prevalent population of CRC in the 7 major markets was estimated to be 17,600,264 in 2020. The total diagnosed prevalent population of CRC in the 7 major markets was estimated to be 10,560,159 in 2020. In case of CRC patients in the United States, the diagnosed prevalent cases were 4,802,273 in 2020. The diagnosed prevalent population of CRC in the 7 MM is expected to increase at a CAGR of 0.48% during the forecast period 2021-2030. […] The report covers the descriptive overview of Chronic Refractory Cough (CRC), explaining its causes, signs and symptoms, pathophysiology. The report provides insight into the 7MM historical and forecasted patient pool covering the United States, EU5 countries (Germany, France, Italy, Spain, and United Kingdom) and Japan. The report assesses the disease risk and burden and highlights the unmet needs of Chronic Refractory Cough (CRC).

• #32 Cough in Idiopathic Pulmonary Fibrosis (IPF) Epidemiology

  https://www.globenewswire.com/news-release/2025/02/11/3024362/28124/en/Cough-in-Idiopathic-Pulmonary-Fibrosis-IPF-Epidemiology-Market-Forecast-Research-2020-2034.html

  The report delivers an in-depth understanding of the Cough in Idiopathic pulmonary fibrosis (IPF), historical and forecasted epidemiology in the United States, EU4 (Germany, France, Italy, and Spain) and the United Kingdom, and Japan. […] The Cough in Idiopathic pulmonary fibrosis (IPF) epidemiology chapter in the report provides historical as well as forecasted epidemiology segmented by Total Diagnosed Prevalent Cases of Idiopathic pulmonary fibrosis (IPF), and Total Diagnosed Prevalent Cases of Cough in Idiopathic pulmonary fibrosis (IPF) in the 7MM covering the United States, EU4 countries (Germany, France, Italy, and Spain) and the United Kingdom, and Japan, from 2020 to 2034. […] According to estimates in 2022, the total diagnosed prevalent cases of Cough in IPF in the 7MM were nearly 148,000 in 2022, which is expected to increase by 2034 due to improved awareness, aging populations, and advancements in diagnostic capabilities.

• #33 Cough in Idiopathic Pulmonary Fibrosis (IPF) Epidemiology

  https://www.globenewswire.com/news-release/2025/02/11/3024362/28124/en/Cough-in-Idiopathic-Pulmonary-Fibrosis-IPF-Epidemiology-Market-Forecast-Research-2020-2034.html

  As per the analysis, the diagnosed prevalent cases of cough in IPF in the US were reported to be highest with approximately 75 thousand cases, in 2022. […] In 2022, the 7MM recorded approximately 184,000 diagnosed prevalent cases of IPF, projected to rise by 2034. […] The United States has the highest diagnosed prevalent cases of cough in IPF among the 7MM countries, comprising 51% of the total 7MM cases. […] EU4 and the UK accounted for approximately 55,100 diagnosed prevalent cases of cough in IPF, in 2022. […] In 2022, the total diagnosed prevalent cases of IPF in Japan were found to be approximately 21,000 among which cough in IPF cases accounted for approximately 16,800 cases.

• #34

  https://smw.ch/index.php/smw/article/view/3300

  BACKGROUND: Epidemiological studies use different questions to assess recurrent cough in children. In two independent population-based studies, we assessed how prevalence estimates of cough vary depending on the questions parents are asked about their child’s cough and how answers to the different questions overlap. […] In both population-based studies prevalence estimates of cough depended strongly on the question used to assess cough with only partial overlap of responses to different questions. Epidemiological studies on cough can only be compared if they used exactly the same questions for cough.

• #35 Epidemiology and Healthcare Service Utilization among Adults with Chronic Cough

  https://www.mdpi.com/2077-0383/13/11/3230

  The cough is the most common symptom for which adults seek medical treatment in a non-hospital setting. Among the myriad of manifestations of cough, chronic cough (CC), persisting for more than eight weeks, emerges as a prevalent condition with estimated prevalence rates ranging from 1% to 40%. Beyond its prevalence, CC compromises patients’ overall quality of life, affecting physical, social, and psychological dimensions. […] Despite the wealth of knowledge surrounding CC and the existence of guidelines for its diagnosis and management, a critical gap persists in the availability of population-based data encompassing demographics, clinical characteristics, diagnostic evaluations, treatment patterns, and healthcare service utilization (HCRU) related to CC.

• #36 Syndromic surveillance of population-level COVID-19 burden with cough monitoring in a hospital emergency waiting room.

  https://escholarship.org/uc/item/54c480n0

  Syndromic surveillance is an effective tool for enabling the timely detection of infectious disease outbreaks and facilitating the implementation of effective mitigation strategies by public health authorities. […] the aggregated measurement of cough, an important symptom for many illnesses, is not widely employed as a syndromic signal. […] In this work, we demonstrate the utility of monitoring aggregated cough count as a syndromic indicator to estimate COVID-19 cases. […] Our analysis revealed a significant correlation between the aggregated cough count and positive COVID-19 cases in the hospital (Pearson correlation of 0.40, p-value 0.001). […] Furthermore, we demonstrate how the data obtained from our Syndromic Logger platform could be leveraged to estimate various COVID-19-related statistics using multiple modeling approaches. […] Our findings highlight that incorporating cough-counting based signals into syndromic surveillance systems can significantly enhance overall resilience against future public health challenges, such as emerging disease outbreaks or pandemics.

• #37 Digital acoustic surveillance for early detection of respiratory disease outbreaks in Spain: a protocol for an observational study | BMJ Open

  https://bmjopen.bmj.com/content/11/7/e051278

  To our knowledge, digital cough monitoring for early detection of respiratory disease outbreaks has never been performed. […] This study will address those questions. It will also generate operational expertise and qualitative knowledge on the facilitators to be exploited, and the barriers to be addressed in order to maximise uptake and impact prior to implementation on a wider scale.

• #37 Digital acoustic surveillance for early detection of respiratory disease outbreaks in Spain: a protocol for an observational study | BMJ Open

  https://bmjopen.bmj.com/content/11/7/e051278

  Cough is a common symptom of COVID-19 and other respiratory illnesses. However, objectively measuring its frequency and evolution is hindered by the lack of reliable and scalable monitoring systems. […] In the context of the ongoing COVID-19 pandemic, cough detection for respiratory disease syndromic surveillance represents a simple means for early outbreak detection and disease surveillance. […] We propose that COVID-19 surveillance and early outbreak recognition can be enhanced by digitally monitoring cough and detecting changes in its incidence at population level. […] This approach would be of particular value in low-income and middle-income countries where (a) capturing passive data through health services is insufficient given unequal access to healthcare, and (b) active case detection and contact tracing capacity is limited.

• #38 Chronic cough: epidemiology, pathophysiology, diagnosis and management

  https://www.biomedcentral.com/collections/ccepdm

  Recent advances are improving our understanding of the mechanisms contributing to cough hypersensitivity and excessing coughing, paving the way for new therapies. However, more research is needed to improve patients’ lives and translate novel discoveries to the clinic. […] Epidemiological studies on cough hypersensitivity and chronic cough.

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