Materiały źródłowe

• #1

  https://www.healio.com/news/ophthalmology/20250213/technology-education-key-to-changing-presbyopia-treatment-paradigm

  Few conditions impact as many people worldwide as presbyopia. Recent estimates have placed the prevalence of presbyopia in the 2 billion range. […] Waring said, There is an opportunity before us, a dogma shift, surrounding which patients are candidates for presbyopia correction. Thanks to recent advances in technology and new options on the horizon, that shift may be coming. […] However, the safety benefit of a solution that goes beyond multifocal glasses should outweigh those concerns, Chang said. A large part of changing this perception falls on physicians to educate their patients and introduce them to the technology, he said. […] New technology means that addressing presbyopia has become more sophisticated. Waring said there have been proposals to establish a new subsector of refractive surgery to group all the different procedures that surgeons may use.

• #2 Presbyopia Treatment Market Set to Reach New Heights with New Therapies and Advancements by 2034 | DelveInsight

  https://www.prnewswire.com/news-releases/presbyopia-treatment-market-set-to-reach-new-heights-with-new-therapies-and-advancements-by-2034–delveinsight-302305165.html

  The launch of emerging therapies, such as LNZ100 by Lenz Therapeutics, Phentolamine Ophthalmic Solution 0.75% by Viatris and Ocuphire Pharma, BRIMOCHOL PF (VT-1011) by Visus Therapeutics, among others will significantly impact the presbyopia market during the forecast period (2024-2034). […] Treatment options for presbyopia mainly consist of corrective lenses and surgical procedures. Non-invasive methods, such as reading glasses, bifocals, and progressive lenses, enhance vision at different distances. […] Recently, eye drops like pilocarpine hydrochloride have gained attention as a promising treatment, as they temporarily enhance near vision by constricting the pupil to improve depth of field. […] VUITY (1.25% pilocarpine HCl ophthalmic solution), developed by Allergan, is a groundbreaking treatment for presbyopia that received FDA approval in October 2021. This prescription eye drop functions by constricting the pupil, which improves near and intermediate vision while minimally impacting distance vision.

• #3 Presbyopia – Diagnosis and treatment – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/presbyopia/diagnosis-treatment/drc-20363329

  Presbyopia is diagnosed by a basic eye exam, which includes a refraction assessment and an eye health exam. […] The goal of treatment is to compensate for the inability of your eyes to focus on nearby objects. Treatment options include wearing corrective eyeglasses (spectacle lenses) or contact lenses, undergoing refractive surgery, or getting lens implants for presbyopia. […] Eyeglasses are a simple, safe way to correct vision problems caused by presbyopia. […] People who don’t want to wear eyeglasses often try contact lenses to improve their vision problems caused by presbyopia. […] Refractive surgery changes the shape of your cornea. For presbyopia, this treatment can be used to improve close-up vision in your nondominant eye. […] Some ophthalmologists use a procedure in which they remove the lens in each eye and replace it with a synthetic lens. This is called an intraocular lens. […] Some people have had success with a presbyopia treatment that involves inserting a small plastic ring with a central opening, into the cornea of one eye.

• #4 Presbyopia – Symptoms and causes – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/presbyopia/symptoms-causes/syc-20363328

  Presbyopia usually becomes noticeable in your early to mid-40s and continues to worsen until around age 65. […] You can correct the condition with eyeglasses or contact lenses. You might also consider surgery. […] See an eye doctor if blurry close-up vision is keeping you from reading, doing close-up work or enjoying other normal activities. He or she can determine whether you have presbyopia and advise you of your options. […] Presbyopia is caused by a hardening of the lens of your eye, which occurs with aging. As your lens becomes less flexible, it can no longer change shape to focus on close-up images. As a result, these images appear out of focus. […] Almost everyone experiences some degree of presbyopia after age 40. […] Certain drugs are associated with premature presbyopic symptoms, including antidepressants, antihistamines and diuretics. […] A review of the surgical options for the correction of presbyopia.

• #5 7 Treatments for Presbyopia Correction – Better Vision Guide

  https://www.bettervisionguide.com/7-presbyopia-treatments/

  Presbyopia is an unavoidable age-related condition that causes near vision problems in people aged 40 and over. The good news is that presbyopia can be easily diagnosed through a routine eye exam, and there are a number of treatment options available to help restore near vision. […] Check out these seven common treatments for presbyopia correction: […] By far the most common (and simplest) treatment for presbyopia is bifocal or progressive lens eyeglasses. […] Multifocal and monovision contact lenses are very common treatments for presbyopia. […] Although LASIK cannot treat the root cause of presbyopia, there are LASIK variations that can help reduce your need for reading glasses or bifocals. […] Monovision LASIK is the most widely used surgical correction for presbyopia. […] Multifocal LASIK (also called PresbyLASIK) creates multiple power zones across the surface of the cornea to improve the depth of clear vision focus at any distance.

• #6 Presbyopia: Symptoms, Diagnosis, and Treatment

  https://www.webmd.com/eye-health/eye-health-presbyopia-eyes

  There’s no cure for presbyopia, but there are a lot of ways to improve it. […] Reading glasses/Readers: Yes, those cheap glasses you see at the drugstore can often do the trick because they magnify, or enlarge, what you’re viewing. Pick the weakest pair that lets you see what you need to read. […] Bifocals: They work for many people. If you have prescription glasses already, this might be the option for you. They’re eyeglasses with two different prescriptions in one lens. The top part corrects for distance vision. The lower section helps you see objects up close. […] Trifocals: They have three different prescriptions in the lens that will help you see close-up, far away, and an intermediate distance. […] Progressive lenses: These are similar to bifocals, but there’s a gradual or blended transition between the two prescriptions instead of separate sections.

• #7 Diagnosis and Treatment – Moorfields Private

  https://www.moorfields.nhs.uk/private/eye-conditions-and-treatments/presbyopia/diagnosis-and-treatment

  Moorfields Private offers three main vision correction options to treat presbyopia and remove the need for glasses or contact lenses. […] It is generally possible to correct presbyopia with reading glasses, which you can buy off the shelf in most pharmacies, opticians and larger supermarkets. […] People who also have myopia often find that bifocal or varifocal glasses are the solution once they develop presbyopia too.

• #8 Presbyopia – Symptoms, Causes, Diagnosis and Treatment | MedPark Hospital

  https://www.medparkhospital.com/en-US/disease-and-treatment/presbyopia

  Trifocals are for a close-up, middle-distance computer screen, and distance visions. They have two visible horizontal lines across the lenses. […] Progressive multifocal has different focusing strengths on a single lens. […] Office progressives are for computer-distance and close work. It is suitable for people who don’t need glasses driving or walking. […] Contact lenses […] Bifocal contact lenses are available in soft and hard materials. They have two focal points, near and far. […] Multifocal contact lenses have three focal points near, middle, and far, available in soft and hard materials. […] Monovision contact lenses include one lens for near vision and the other for far vision; you wear one on each eye. It may take up to 2 weeks for your brain to adjust. […] Modified monovision contact lenses have one lens for either near or far vision and a multifocal lens for the other eye.

• #9 Treatment Options for Presbyopia | Optometrist in Reading, PA | Lisa M. McDevitt, O.D.

  https://drmcdevitteyecare.com/articles/default/898946-treatment-options-for-presbyopia

  Progressive Lenses. Progressive lenses work the same way as bifocals and trifocals without the lines. […] Contact Lenses. Multi-focal contact lenses offer several lens powers in one contact lens. Each power gradually transitions to the next one for seamless vision. Monovision contact lenses offer another option. One lens corrects distance vision, while the lens in the other eye improves near vision. Your eye doctor will give you a few trial pairs of monovision lenses, as some people feel dizzy wearing different lenses in each eye. […] Prescription Eye Drops. Special eye drops could also sharpen your near vision. The drops are placed in your eyes once a day and improve your vision for as long as six hours. […] Surgical Options Your Optometrist Can Suggest […] LASIK Refractive Surgery. Laser-Assisted In Situ Keratomileusis (LASIK) provides a permanent solution to vision changes caused by presbyopia. During the surgery, your eye doctor uses a laser or a blade to make a small flap in your cornea, the clear tissue that covers the iris or pupil. A laser reshapes the underlying layers of the cornea, correcting your vision. If you choose LASIK, one eye will be corrected for near vision and the other for far. It may be a good idea to try monovision contact lenses for a few days before the surgery to ensure that this will be a good option for you.

• #10 Presbyopia: Symptoms, Diagnosis, and Treatment

  https://www.webmd.com/eye-health/eye-health-presbyopia-eyes

  Contact lenses can also treat presbyopia. You might try: Multifocal lenses: They come in soft or gas-permeable versions. […] Monovision lenses: One lens helps you see objects at a distance. The other is for close-up vision. […] Pilocarpine eye drops (Vuity) are available by prescription to help treat presbyopia. The drops work by making your pupil smaller, improving your focus on objects nearby. […] Laser surgery for presbyopia involves correcting one eye for distance vision and the other eye for near vision. […] An intraocular lens (IOL) is an artificial lens for your eye. There are three presbyopia-correcting IOLs that can improve your focusing power. […] Intracorneal inlays are minimally invasive implants that help improve presbyopia, but they’re not as popular as other surgery treatments like LASIK. […] Other treatments continue to be researched to help presbyopia. Ask your eye doctor about options for your presbyopia and what’s best for you.

• #11 Treatment Options For Presbyopia – Eagle Eye Centre

  https://eagleeyecentre.com.sg/treatment-options-for-presbyopia/

  Monovision addresses the problem of Presbyopia that most people start to experience at the age of 40-45 when they begin to need reading glasses or bifocals for close vision. […] One way of dealing with Presbyopia is to use LASIK to produce monovision. […] Multifocal lens implants are suitable for selected patients with cataracts and can help achieve total spectacle independence and may be the best treatment option for presbyopia and cataracts today. […] A multifocal contact lens possesses several zones of differing power to assist the eye gradually as it changes focus on different objects at different distances. […] There are many methods to correct Presbyopia. […] Multifocal spectacles are also known as progressive addition lenses (PALs) that allows one to focus on objects through different prescriptions for different distances through the same lens.

• #12 Pharmacological Treatment in Presbyopia

  https://pmc.ncbi.nlm.nih.gov/articles/PMC8910925/

  Pharmacological treatment of presbyopia may be an alternative for those who want a spectacle-free scenario and an easy-to-use method with lower risk of irreversible ocular adverse events. […] There are two main agents, miotics and lens softeners, investigated as agents for the pharmacological treatment. […] Miotic agents treat presbyopia by creating a pinhole effect which may increase the depth of focus at all working distances. […] The recent approval of 1.25% pilocarpine for treatment of presbyopia by the US FDA may be an important milestone for investigation of real-world data of pharmacological treatment of presbyopia. […] Pharmacological treatment of presbyopia has been studied in recent years based on different drugs and different treatment regimens. […] In November 2021, U.S. FDA has approved 1.25% pilocarpine hydrochloride ophthalmic solution (AGN-190584) as an eye drop for treating presbyopia.

• #13 A Review of Pharmacological Presbyopia Treatment

  https://pmc.ncbi.nlm.nih.gov/articles/PMC7299227/

  Presbyopia reduces an individual’s ability to perform visual tasks at near distances. It is a global problem, affecting over a billion people worldwide. Contact lenses, glasses, refractive surgery, and intraocular lens surgery are the main modalities in presbyopia treatment, although they all have some disadvantages. Thus, there is an increasing need for effective, easy-to-use, and noninvasive approaches for treating presbyopia while not limiting patients daily activities. Pharmacological presbyopia treatment as an alternative method has been under investigation in recent years. […] Most of the currently available treatments for presbyopia are surgical and invasive, and hence there is a risk of infection, and all methods have their side effects, as outlined above. There is undoubtedly a need to develop a noninvasive treatment that is effective in recovering accommodative function and providing good vision at all distances, which could be applied in patients with early symptoms of presbyopia and would be easily available. Interest in pharmacological presbyopia treatment has increased significantly during the last decade, so our aim is to review the main reports and results of clinical trials based on pharmacological presbyopia treatment approaches.

• #14 Pharmacological Treatment in Presbyopia

  https://pmc.ncbi.nlm.nih.gov/articles/PMC8910925/

  The aim of this article is to review current pharmacological treatment for presbyopia. […] Most of the current presbyopia pharmacological treatment options aim at inducing temporary miosis causing a pinhole effect to increase the depth of focus through parasympathetic pathway. […] The U.S. FDA Approved Agent for Presbyopia: Pilocarpine is a miotic agent that has been used and studied in different concentrations, different forms and also as a combination with other drugs for presbyopia. […] The daily use of pilocarpine hydrochloride ophthalmic solution 1.25% monotherapy in both eyes is the regimen which has been approved by the U.S. FDA. […] There was another phase 2 multi-centered, double-masked, placebo-controlled, randomized, parallel-group study on 1.5% lipoic acid choline ester chloride compared with placebo.

• #15 Pharmacological Treatment in Presbyopia

  https://pmc.ncbi.nlm.nih.gov/articles/PMC8910925/

  Lens softeners should theoretically be a better treatment option than miotics because they addressed the etiology of presbyopia and did not alter the normal physiological function of the eyes. […] With the recent U.S. FDA approval of 1.25% pilocarpine for treatment of presbyopia, this agent is becoming an alternative option for those in the US who may not want to wear spectacles for near tasks. […] There are ongoing studies on other miotic agents, as monotherapy or in combination with other agents as treatment of presbyopia. […] Pharmacological treatment of presbyopia is, without a doubt, one of the promising fields in research in ophthalmology since all people who are more than 45 years old will have this condition eventually.

• #16 Presbyopia: Symptoms, Causes & Treatment

  https://my.clevelandclinic.org/health/diseases/8577-presbyopia

  Presbyopia is part of the natural aging process, and its not a disease. Its a common type of refractive error that eye care specialists can easily correct with glasses, contacts or surgery. […] Depending on your health, lifestyle and preferences, your eye care specialist may suggest any of the following methods to correct presbyopia: Eyeglasses, Contact lenses, Surgeries, Eye drops. […] Eye drops are a good option for some people with presbyopia. Pilocarpine eye drops (Vuity) make your pupil smaller to improve your depth of focus and give you clearer close-up vision. These are the first eye drops the U.S. Food and Drug Administration (FDA) has approved for presbyopia. […] The following three laser procedures correct presbyopia by using monovision (one eye corrected for distance, the other corrected for near vision): LASIK surgery, PRK surgery, SMILE surgery.

• #17 List of 3 Presbyopia Medications Compared

  https://www.drugs.com/condition/presbyopia.html

  Presbyopia is commonly known as age-related blurry near vision. It is a progressive condition that usually begins around the age of 40, and affects nearly half of the U.S. adult population. […] Treatment for presbyopia includes the use of glasses or contact lenses to help with reading. […] Vuity (pilocarpine hydrochloride) and Qlosi (pilocarpine hydrochloride) are FDA-approved eye drops to treat presbyopia. Pilocarpine hydrochloride is a cholinergic muscarinic receptor agonist that works to improve near and intermediate visual acuity by contracting the iris sphincter muscle to constrict the pupil.

• #18 Presbyopia Treatment Market Set to Reach New Heights with New Therapies and Advancements by 2034 | DelveInsight

  https://www.prnewswire.com/news-releases/presbyopia-treatment-market-set-to-reach-new-heights-with-new-therapies-and-advancements-by-2034–delveinsight-302305165.html

  QLOSI (0.4% pilocarpine hydrochloride ophthalmic solution), developed by Orasis Pharmaceuticals, is a new treatment for presbyopia that received approval from the US FDA in October 2023. […] LNZ100, developed by Lenz Therapeutics, is an experimental treatment for presbyopia that is currently progressing through Phase III clinical trials. […] BRIMOCHOL PF (VT-1011) is a drug under development by Visus Therapeutics aimed at treating presbyopia. […] Phentolamine Ophthalmic Solution 0.75%, being developed by Viatris and Ocuphire Pharma, aims to treat presbyopia. […] The anticipated launch of these emerging therapies for presbyopia are poised to transform the market landscape in the coming years. […] DelveInsight estimates that the market size for presbyopia is expected to grow from USD ~17 billion in 2023 with a CAGR of 3.2% by 2034.

• #19 Pharmacological Treatment in Presbyopia

  https://www.mdpi.com/2077-0383/11/5/1385

  The daily use of pilocarpine hydrochloride ophthalmic solution 1.25% monotherapy in both eyes is the regimen which has been approved by the U.S. FDA. […] The pooled results from both studies showed that, for the primary outcome, the percentage of participants in the treatment group who gained at least 3-line in mesopic, high-contrast, binocular DCNVA was significantly greater than the percentage of those in the placebo group. […] The most common adverse event related to this agent in the pooled data was headache at 14.9%. […] There was another phase 2 multi-centered, double-masked, placebo-controlled, randomized, parallel-group study on 1.5% lipoic acid choline ester chloride compared with placebo. […] Lens softeners should theoretically be a better treatment option than miotics because they addressed the etiology of presbyopia and did not alter the normal physiological function of the eyes.

• #20 CRSToday | Pharmacologic Treatments for Presbyopia

  https://crstoday.com/articles/july-2024/pharmacologic-treatments-for-presbyopia

  As the first topical treatment for presbyopia, Vuity’s launch in 2021 generated interest and excitement in the ophthalmic and lay press. Although the agent does not achieve a sub-2-mm pupil, the drug improves near visual acuity in many individuals. The pupillary nadir for Vuity occurs 1 hour after instillation. By 4 hours, the mean pupil size has enlarged to approximately 3 mm, providing minimal near benefit. In March 2023, the US FDA approved the drug for twice-daily dosing, extending its duration of effect. […] Lenz Therapeutics recently released data from the phase 3 CLARITY trial, and the results were encouraging. At 30 minutes and 3 hours after drug instillation, 71% of participants experienced at least 3 lines of improvement in their near visual acuity, and the effect persisted for 10 full hours in 40% of participants. A placebo-corrected headache incidence of 7.6% was reported, and the side effect was mild in most cases.

• #21  6 Top Treatment Options for Presbyopia

  https://www.professionalvisioncareinc.com/6-top-treatment-options-for-presbyopia/

  Monovision LASIK is the most widely used surgical correction for presbyopia. […] For refractive lens exchange (RLE), an eye surgeon replaces your eyes natural lens using an artificial intraocular lens (IOL). The IOL improves near vision and reduces your need for near vision solutions such as reading glasses. […] Eye drops are among the newest solutions for the treatment of presbyopia and are most effective in patients who have just begun to experience symptoms. They are miotic drops, meaning they rely on making the pupil contract to create a pinhole effect that mimics the eyes natural ability to focus. This allows for improved vision close-up in patients with presbyopia.

• #22 Presbyopia Treatment – EyeWiki

  https://eyewiki.org/Presbyopia_Treatment

  PresbyLASIK is a multifocal excimer laser approach, which aims to reshape the cornea for both near and far vision in each eye. […] INTRACOR is a procedure that traditionally involves placement of 5 intrastromal rings in the center of the visual axis using a femtosecond laser, leading to central corneal steepening, and an increased depth of focus. […] Photorefractive keratectomy (PRK) like LASIK is a surgical procedure that uses an excimer laser to reshape the surface of the cornea. However, unlike LASIK, no flap is created. […] Scleral implants have been used to increase the area between the ciliary muscle and the sclera to restore accommodation based on Schachar theory. Different types of implants have been used.

• #23 Presbyopia Edison | Conductive Keratoplasty Kendall ParkPresbyopia Edison | Conductive Keratoplasty Kendall Park

  https://www.pateleyeassociates.com/common-eye-problems-edison/presbyopia/

  You can also choose from a variety of contact lens options, such as multi-focal or mono-vision lenses, to treat the condition. […] There are also a variety of surgical treatments for presbyopia, including: Conductive keratoplasty (CK), uses radio waves to reshape the corneal curvature, improving near vision. CK is performed on a single eye. […] Many presbyopia patients do best with reading glasses and multifocal contact lenses, at least in the early stages of the condition. […] As one of the most well-regarded plastic surgeons performing Presbyopia in Edison, New Jersey, Dr. Hitesh K. Patel is here to answer all your questions about Presbyopia. […] There is no cure for presbyopia, though there are many treatments that can help you see more clearly up-close or when your eyes need to transition from near to distance work. Presbyopia treatment may include glasses, contact lenses, or vision correction surgery. […] Even if you opt for vision correction surgery to restore your vision, you may still wear glasses or contacts. Individual results vary.

• #24 Presbyopia Treatment – EyeWiki

  https://eyewiki.org/Presbyopia_Treatment

  The most widely studied corneal inlay, the Kamra inlay, was approved by the FDA in April 2015. The Kamra corneal inlay improves near and intermediate vision by way of its small central aperture, placed in the area on or between the pupil center and the corneal vertex, thereby creating a pinhole effect and increasing depth-of-focus. […] The Raindrop Near Vision inlay was approved by the FDA in June 2016 as a treatment for presbyopia following the results of a large prospective, multi-center FDA clinical trial that demonstrated long-term improvement in near vision with minimal adverse events. […] Monovision is a correction strategy that corrects one eye for near vision and the other eye for distance vision (usually the dominant eye). LASIK-induced monovision is overall very effective at bringing about good functional near and far vision.

• #25 Presbyopia treatment options now and on the horizon – EyeWorld

  https://www.eyeworld.org/2021/presbyopia-treatment-options-now-and-on-the-horizon/

  Shamik Bafna, MD, said he tends to break down the treatment options for presbyopia by what is accessible in the U.S. and whats available outside the U.S. […] While monovision is one of the most popular options within the U.S. for presbyopia correction, another strategy Dr. Bafnas practice employs is an inlay, specifically the Kamra (AcuFocus). […] He also mentioned allografts, which use actual corneal tissue instead of a foreign body. […] Dr. Waring mentioned the blended vision approach with LASIK and/or PRK and with implantable contact lenses. […] Dr. Bafna said that PRESBYOND is used a fair amount outside the U.S., and he wishes it was available here. […] Dr. Bafna discussed lens-based options. […] There are a lot of different lenses in development, Dr. Bafna said. […] The main downside of multifocal lenses is they use a diffractive optic that splits light, so patients will have some dysphotopsia, especially at night.

• #26 How Do You Treat Presbyopia Besides Reading Glasses, Anyway? – Omaha Eye and Laser Institute

  https://www.omahaeye.com/featured/how-do-you-treat-presbyopia-besides-reading-glasses-anyway/

  Presbyopia is a prevalent eye condition that primarily affects older adults once they are in their forties or fifties. […] The go-to treatment for presbyopia is reading glasses. […] Vision correction procedures that treat presbyopia are much more convenient and may help reduce your dependence on prescription glasses and contact lenses. […] Refractive lens exchange, or RLE, is a vision correction procedure that corrects presbyopia. […] Certain IOLs are designed to correct at least some degree of presbyopia. […] For the best results after refractive lens exchange, including reducing your dependence on visual aids like reading glasses, it’s worth considering a premium IOL. […] Monovision IntraLASIK is like LASIK, but instead of correcting refractive errors, it corrects your vision in one eye to see best up close and in the other eye to see at a distance.

• #27 Presbyopia treatment options now and on the horizon – EyeWorld

  https://www.eyeworld.org/2021/presbyopia-treatment-options-now-and-on-the-horizon/

  Extended depth of focus lenses include the Symfony (Johnson Johnson Vision) and Vivity (Alcon). […] Dr. Waring said he thinks one of the most exciting areas of presbyopia surgery is lens replacement procedures. […] We think of presbyopia as one of the emerging subspecialties within the specialty of refractive surgery and refractive cataract surgery, Dr. Waring said. […] Another presbyopia treatment in development is the use of eye drops, though no product is currently approved by the FDA. […] If approved, it will be the first eye drop to help reduce dependence on reading glasses and contact lenses for the treatment of presbyopia. […] Dr. Bafna highlighted the eye drops under investigation, primarily in clinical trials. […] The idea is that patients will only have to apply drops once or twice a day. […] For patients who want a stop gap measure between glasses or contacts and a surgical procedure, he thinks these drops are a good noninvasive methodology.

• #28 How Do You Treat Presbyopia Besides Reading Glasses, Anyway? – Omaha Eye and Laser Institute

  https://www.omahaeye.com/featured/how-do-you-treat-presbyopia-besides-reading-glasses-anyway/

  Talk to your eye doctor about your options. […] One significant advantage of having refractive lens exchange is that if you have the procedure, you’ll never have to worry about having cataracts. […] Many patients choose refractive lens exchange, knowing they will never have cataracts and can look forward to many years of crisp, clear vision after the procedure.

• #29

  https://www.healio.com/news/ophthalmology/20250213/technology-education-key-to-changing-presbyopia-treatment-paradigm

  Ang said the new frontier for presbyopia is in patients with emmetropic presbyopia. […] Theres no treatment that specifically addresses emmetropic presbyopia, he said. […] The newest eye drop solution is Qlosi (pilocarpine hydrochloride ophthalmic solution 0.4%, Orasis Pharmaceuticals). […] One method in the pipeline, laser scleral microporation (LSM, Ace Vision Group), could offer surgeons an option that addresses the root cause of presbyopia without the traditional trade-offs. […] Ang said LSM softens the scleral wall where the muscles are attached, making it more pliable. […] One of the biggest barriers to better and more widespread presbyopia correction is education, according to Chang. […] It begins with understanding what the factors and issues are, how they apply and how we can apply them to patients, he said.

• #30

  https://www.healio.com/news/ophthalmology/20210914/treatment-landscape-for-presbyopia-evolving-toward-noninvasive-options

  Multiple options with different nuances in terms of concentration, combination of active ingredients, ways of administration and duration of action will give patients the chance to find the best strategy for their individual needs. […] Patients will enjoy having the flexibility of choosing the drop that works best for them, Donnenfeld said. […] Drops used for other purposes, such as glaucoma, have been associated with poor adherence, partly due to the burden of multiple administrations. However, motivation and the immediate effect of drops for presbyopia will positively affect compliance. […] The side effects of pilocarpine-based drops can be red eye and headache associated with the mechanism of action of miotics. […] According to Ang, LSM is one of the most promising techniques for presbyopia because it tackles the root of the problem, partially restoring the conditions for the eye to accommodate, and holds innumerable advantages.

• #31

  https://www.healio.com/news/ophthalmology/20210914/treatment-landscape-for-presbyopia-evolving-toward-noninvasive-options

  The main advantage is that it does not touch the cornea and has no impact on the visual axis. […] He said that unlike other procedures, which include monovision or pseudoaccommodation, LSM does not require neuroadaptation. […] LSM rejuvenates the rigid scleral tissue making it more compliant during ciliary muscle contraction, but you need to exercise this new ability. […] The only side effect we discovered, and positively surprised us, is that it lowers IOP. […] LSM is a procedure for emmetropic presbyopes but can also serve patients who have previously undergone laser refractive surgery. […] However, the landscape of presbyopia correction is changing for the best toward less invasive, more therapeutic, more comfortable and user-friendly solutions, he said.

• #32 Presbyopia treatment options now and on the horizon – EyeWorld

  https://www.eyeworld.org/2021/presbyopia-treatment-options-now-and-on-the-horizon/

  Dr. Waring noted the many implications of this large number, not just from a quality of life standpoint but also in terms of economic burden related to falls. […] We have proposed an algorithm for the treatment of presbyopia based on age, refractive status, and lens opacity, he said. […] Dr. Waring said treatment options are largely dictated by patients refractive status, meaning if theyre hyperopic and the higher the degree of hyperopia, the earlier a lens-based intervention procedure may be recommended. […] For the plano presbyope, Dr. Waring said they are moving toward a lens-based procedure to maintain binocularity, which he thinks improves vision performance and may lead to higher patient satisfaction. […] When considering age, once pharmacologic therapies are approved for the treatment of presbyopia, we may initially recommend that as an alternative to glasses and contacts, Dr. Waring said.

• #33 7 Treatments for Presbyopia Correction – Better Vision Guide

  https://www.bettervisionguide.com/7-presbyopia-treatments/

  Corneal inlays are tiny implantable lenses that are surgically placed in the cornea to improve vision affected by presbyopia. […] Conductive keratoplasty has been studied as a treatment for other eye conditions including keratoconus and astigmatism. […] Refractive lens exchange (RLE) treatment for presbyopia is similar to that used for cataract surgery. […] The best solution for each patient depends on age, current status of distance vision, and personal preference.

• #34 Presbyopia Correction: Exploring the Best Treatment Options

  https://garibaldieyecare.com/blog/treatment-options-for-presbyopia-correction-what-works-best/

  Treatment Options for Presbyopia Correction: What Works Best? Presbyopia is a typical age-related vision condition experienced by many as they age. […] Choosing the correct treatment for presbyopia correction is critical to preserving one’s vision and lifestyle. A wide variety of treatment options exist for presbyopia, each with its benefits and considerations: Corrective Eyewear: One of the most common solutions to address presbyopia is using corrective eyewear. Eyeglasses, for instance, operate by adjusting the way light enters the eyes, compensating for the eye’s loss of flexibility. […] Contact Lenses: Some individuals prefer a less conspicuous solution and opt for contact lenses. […] Refractive Surgery: Refractive surgery is an option for a more lasting resolution. […] Lens Implants: Lens implants introduce a synthetic lens into the eye, replacing the natural lens.

• #35 Presbyopia Correction: Exploring the Best Treatment Options

  https://garibaldieyecare.com/blog/treatment-options-for-presbyopia-correction-what-works-best/

  Prescription Eye Drops: In recent years, the field of ophthalmology has seen exciting developments in the form of prescription eye drops. […] Choosing the most suitable presbyopia treatment isn’t a decision to be made lightly. […] The best treatment should align with an individual’s unique needs and lifestyle. […] The current health status of a person’s eyes can limit or expand treatment options. […] The treatment chosen should be comfortable for the individual. […] A broad spectrum of effective treatment options exists for those grappling with presbyopia. […] With advancements in eye care, there are increasingly comprehensive solutions available. […] It is strongly advocated for individuals to engage in open dialogues with their eye care specialists.

• #36 Presbyopia Drugs: A Drop in the Bucket?

  https://www.reviewofoptometry.com/article/presbyopia-drugs-a-drop-in-the-bucket

  A slew of next-generation products are hoping to leap these hurdles. Lets review whats being proposed. […] Some investigational presbyopia therapies use two active ingredients in hopes of overcoming the limitations of pilocarpine alone. Brimochol, currently in development by Visus Therapeutics, doesnt use pilocarpine at all. Instead, its active ingredients are carbachol, a cholinergic agent, and brimonidine tartrate, an alpha-2 agonist. The two active agents are supposed to complement each other in their effects. […] Like Vuity, Brimochol is supposed to be administered once daily, and Visus claims its product will work for a minimum of eight hours. […] Other companies are taking a different approach to improve efficacy, opting for a lower strength pilo but more frequent instillation rather than doubling down on active ingredients. Thats the plan for CSF-1, a low-dose pilocarpine drop being developed by Orasis Pharmaceuticals.

• #37 Presbyopia Drugs: A Drop in the Bucket?

  https://www.reviewofoptometry.com/article/presbyopia-drugs-a-drop-in-the-bucket

  Adverse events included headache in 6.8% of participants and instillation site pain in 5.8%. Moderate adverse events were present in 2.6%. […] Much different from any of the other options, at least in terms of drug delivery method, Eyenovias MicroLine solution is meant to be dispensed through an aerosol dispenser it calls Optojet. […] Combining pilocarpine with a novel agent is a further treatment possibility. Ocuphires Nyxol is another product with a unique active ingredient: 0.75% phentolamine ophthalmic solution. […] The Nyxol plus pilocarpine solution displayed full efficacy by 30 minutes and extended near vision improvement for at least six hours in the VEGA I trial. […] Theres no shortage of new agents being tested as alternatives to pilocarpine. One final presbyopia drug in the near-term pipeline that fits this description is PRX-100. Currently being developed by Lenz Therapeutics, this drops active ingredient is aceclidine, a cholinergic agonist. […] With this type of agent, Lenz was able to advance PRX-100 past Phase II. […] The general consensus from all doctors was that the cost will be worth it to some patients and others not. It really depends on the patients expectations and what they value in a treatment.

• #38 CRSToday | Pharmacologic Treatments for Presbyopia

  https://crstoday.com/articles/july-2024/pharmacologic-treatments-for-presbyopia

  Pharmacologic Treatments for Presbyopia […] More than a billion individuals worldwide experience presbyopia. Interest in the surgical correction of the condition remains high, but nonsurgical methods also hold appeal. Current pharmacologic efforts to address presbyopia center on achieving miosis to increase the depth of focus. In 2023, Novartis terminated its US FDA trial of an alternative approach that used a lipoic acid choline ester (UNR844) to soften the crystalline lens when the study’s primary objective was not met. […] This article discusses the latest developments in pharmacologic treatments for presbyopia. […] The Table shows the current development and approval status of various miotic agents. Of these, only Vuity (pilocarpine HCL ophthalmic solution 1.25%, AbbVie) has been approved by the US FDA and made commercially available. Qlosi (pilocarpine HCL ophthalmic solution 0.4%, Orasis Pharmaceuticals) has also been approved by the US FDA but is not yet available.

• #39 Investigational treatment seeks to reverse presbyopia, restore natural accommodation – EyeWorld

  https://www.eyeworld.org/2023/investigational-treatment-seeks-to-reverse-presbyopia/

  The holy grail of presbyopia is to restore the eyes natural ability to dynamically focus for any visual task, including accommodation to focus at near and disaccommodation to focus at far and every distance between. […] Current viable options for patients with presbyopia include corneal substitutionary procedures involving multifocality, monovision, or refractive lens exchange. […] However, there is work being performed by Ace Vision Group on laser scleral microporation, a technique that Prof. Marshall, who is on the companys Scientific Advisory Board, thinks could rejuvenate the eyes natural dynamically focusing process. […] What the microporation is doing is actually uncrosslinking, Dr. Marshall said. Removing small amounts of tissue in a programmed way allows this target recoil of Bruchs membrane and the choroid to function near to its useful state.

• #40 Investigational treatment seeks to reverse presbyopia, restore natural accommodation – EyeWorld

  https://www.eyeworld.org/2023/investigational-treatment-seeks-to-reverse-presbyopia/

  Ace Vision Group conducted preliminary pilot studies using the VisioLite Erbium YAG (Er:YAG) Ophthalmic Laser System, outside of the U.S. […] Prof. Marshall said he thinks the initial results with the treatment are very satisfactory, showing that this concept, the hypothetical issue, is in fact reality and is working. […] This is rejuvenating the process. Its taking the natural process, which has fatigued with age, and setting it back 10, 20, 30 years, he said, noting that unlike other options on the market to treat the effects of presbyopia, the microporation treatment restores the truly dynamic process vs. bridging it with what he called stop-click technologies that dont have smooth, dynamic focusing.

• #41 Presbyopia Treatment: Current and Future Options

  https://www.reviewofcontactlenses.com/article/presbyopia-treatment-current-and-future-options

  Intraocular lenses (IOLs) are not considered a treatment for presbyopia per se, but many ophthalmologists perform lens replacement surgery on patients without cataracts by substituting the healthy crystalline lens with an IOL to correct the refractive error while providing near vision, intermediate vision or both. […] The only AIOLs approved so far in the US are the Crystalens AO and HD. […] The FluidVision AIOL is promoted as the first true shape-changing, fluid-driven AIOL. […] In the near future, it is likely that a pharmaceutical solution will be the first big wave of treatment, and, in that case, a combination approach would be the most effective.

• #42 A Review of Pharmacological Presbyopia Treatment

  https://pmc.ncbi.nlm.nih.gov/articles/PMC7299227/

  A number of new pharmaceutical agents are currently being investigated for the treatment of presbyopia, and results from available studies are promising. The main action mechanisms for presbyopia treatment include the pinhole effect and lens softening. Pupillary miotics increase the depth of focus by creating a pinhole effect. […] Although there is no doubt that pharmacological treatment of presbyopia is an attractive form of therapy, more objective and well-designed studies are needed to evaluate its safety and effectiveness.

• #43 Presbyopia Treatment – EyeWiki

  https://eyewiki.org/Presbyopia_Treatment

  Treatment of presbyopia has historically been limited to corrective lenses such as reading glasses, bifocals, multifocals, and contact lenses. Recent advancements in corrective eye surgery have expanded the number of available modalities for presbyopia correction. With more patients valuing freedom from spectacles and contact lenses, safe and effective surgical correction of presbyopia has become increasingly important. […] Recently, pilocarpine 1.25% was approved for topical use for presbyopia by the FDA. Clinical studies show an improvement in near and intermediate vision within 15 minutes of instillation lasting for up to 6 hours. […] Intraocular procedures for presbyopia correction include intraocular lens implantation with either a multifocal or accommodative lens. Extraocular procedures include corneal inlays and laser refractive surgery, which can be further subdivided into monovision LASIK, presbyLASIK, INTRACOR, and photorefractive keratectomy (PRK).

• #44 Treatment Options For Presbyopia – Eagle Eye Centre

  https://eagleeyecentre.com.sg/treatment-options-for-presbyopia/

  The new small wound pocket insertion KAMRA Inlay procedure is a safe and effective procedure to help restore everyday vision while maintaining distance vision. […] Corneal Inlays are a special range of micro-devices placed within the cornea to offer correction for Presbyopia. […] You should consult with your doctor to discuss all the treatment option. Every treatment option described above may have offered ideal results to some patients but they also have their drawbacks. It is important to weigh out the pros and cons of each treatment with your doctor in accordance to your individual lifestyle. […] Essentially, there is not a one-size fits all treatment option for Presbyopia.

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